| cross reactivity between anaplasma marginale and two plasmodium species as demonstrated by passive hemagglutination. | two types of antigens were prepared from each of 3 partially purified preparations of anaplasma marginale, plasmodium lophurae, and p berghei. hemagglutination tests were conducted with homologous serums to detect antigenic relationships between these organisms. serums were also absorbed with both homologous and heterologous antigen preparations. cross reactivity between these organisms was observed. | 1976 | 779540 |
| a comparison of methods used for the removal of white cells from malaria-infected blood. | | 1976 | 779686 |
| the reactivity of spleen cells from malarious rats to non-specific mitogens. | the reaction of spleen cells from rats infected with plasmodium berghei to non-specific mitogens has been measured. the cells have been stimulated in vitro by phytohaemagglutinin, concanavalin-a and by bacterial lypopolysaccharide. in addition the release of lymphocyte activating factor (laf) by splenic macrophages has been assayed using a heterologous thymocyte culture. the reactivity of spleen lymphocytes from malarious rats is severly affected. the cells do not react either to the t cell-spec ... | 1976 | 780016 |
| plasmodium berghei: adaptation of a mouse-adapted strain to the mongolian jird (meriones unguiculatus); infectivity and immunogenicity. | | 1976 | 780117 |
| plasmodium berghei: development of resistance to clindamycin and minocycline in mice. | | 1976 | 780118 |
| plasmodium berghei: phase contrast and electron microscopical evidence that certain antimalarials can both inhibit and reverse pigment clumping caused by chloroquine. | | 1976 | 780119 |
| plasmodium berghei: combining folic acid antagonists for potentiation against malaria infections in mice. | | 1976 | 780121 |
| t and b cell population changes in young and in adult rats infected with plasmodium berghei. | malaria infection in young rats is characterized by high parasitemia, severe anemia, and death. parasitemia is lower in older rats, and the rats usually survive. this study was designed to investigate the immunological basis of this difference. t cell numbers in the thymuses and spleens of young (4 weeks old) and in adult (18 weeks old) infected and control rats were determined by killing with anti-theta serum and complement. the number of complement receptor lymphocytes (b cells) in spleens was ... | 1976 | 780272 |
| adoptive transfer of immunity to plasmodium berghei with immune t and b lymphocytes. | immunity to malarial infection may be transferred with immune lymphocytes. this study was designed to determine which lymphocyte type is responsible for the adoptive transfer of immunity to malarial infection. in one set of experiments, the ability of immune t and b lymphocytes, separated by passage through nylon-wool columns, to transfer immunity to infection was determined. in another experiment, the effect of killing t lymphocytes with anti-theta serum on the transfer of immunity was determin ... | 1976 | 780273 |
| antimalarials. 3. 1,2,4-triazines. | the syntheses of a number of substituted 1,2,4-triazines as potential antimalarials are described. the structural requirements for antimalarial activity are discussed with reference to the substituents of a phenyl group in the 6 position and amino groups at the 3 and 5 positions. of the compounds tested, 2,5, and 7 produced cures in mice infected with plasmodium berghei. compounds 2(3,5-diamino-6-(4-trifluoromethylphenyl)-1,2,4-triazine),3,5,8,12,and 37 produced cures in chicks infected with pla ... | 1976 | 781244 |
| synthesis, antimalarial activity, and phototoxicity of some benzo(h)quinoline-4-methanols. | nine alpha-dibutylaminomethylbenzo[h]quinoline-4-methanols were synthesized from the corresponding 1-amino-naphthalenes by the following sequence: 1-aminonaphthalene leads to 1h-benz[g]indole-2,3-dione leads to benzo[h]quinoline-4-carboxylic acid leads to acid chloride leads to bromomethyl ketone leads to epoxide leads to benzo[h]quinoline-4-methanol. several acid chlorides substituted in the 3 position reacted incompletely with ethereal diazomethane but were efficiently converted, without isola ... | 1976 | 781245 |
| antimalarials. 9. methylthio- and methylsulfonyl-substituted 9-phenanthrenemethanols. | nine di- and trisubstituted 9-phenanthrenemethanols bearing methylthio and methylfulfonyl substituents in the 2 and/or 6 positions of the phenanthrene nucleus were prepared and screened for antimalarial activity against plasmodium berghei in mice. six of the nine compounds were curative at or below 160 mg/kg. the most active structures contained a methylthio substituent in combination with two chlorine atoms. | 1976 | 781249 |
| the plasmodium berghei-infection in isogenic f1 (c57b1 x dba)- mice. iii. neonatal thymectomy and cell transfer experiments. | in neonatally thymectomized f1(c57bl x dba)-mice the course of an infection with plasmodium berghei, strain k 173, was unaltered if compared with the course in normal animals. no shortening of the survival time was observed. cell transfer experiments were carried out. in numerous trials it was not possible to convey the protective immunity of immune animals to non-immune animals by the transfer of lymphoid cells. if an acquired immunity was destroyed by heavy x-irradiation it could be restored b ... | 1976 | 781956 |
| [behavior of a strain of p.berghei after low temperature preservation during more than 10 years]. | | 1975 | 782384 |
| [antimicrobial action of the combination sulfamoxole/trimethoprim in vivo (author's transl)]. | the experimental infections of the mouse by gram-positive and gram-negative germs are effectively treated with the combination of n1-(4,5-dimethyl-2-oxazolyl)-sulfanilamide (sulfamoxole) and 2,4-diamino-5-(3,4,5-trimethoxy-benzyl)-pyrimidine (trimethoprim) (cn 3123, nevin, supristol). the potentiating effect of both substances is demonstrated by the calculated index of the synergistic effect. the therapeutic efficacy of the combination sulfamoxole/trimethoprim is proved by two models of experime ... | 1976 | 782473 |
| protective activity in sera from mice immunized against plasmodium berghei. | | 1976 | 784936 |
| specific lymphocyte transformation in murine malaria. | lymphoblast transformation tests were performed on convalescent rats and mice, after infection with plasmodium berghei had been reduced to latency. spleen cells from immune animals reacted in vitro to specific plasmodial antigen and not to control antigen produced from non infected rbc. the response in vitro was dependent on the concentration of the antigen and the time of exposure to it. a correlation was observed between the parasitaemia of the convalescent animal during its acute infection an ... | 1976 | 785850 |
| plasmodium berghei: use of free blood stage parasites to demonstrate protective humoral activity in the serum of recovered rats. | | 1976 | 786704 |
| plasmodium berghei: the spleen in sporozoite-induced immunity to mouse malaria. | | 1976 | 786705 |
| plasmodium berghei: heat-treated sporozoite vaccination of mice. | | 1976 | 786707 |
| plasmodium berghei: phagocytic activtiy in two strains of rats. | | 1976 | 786708 |
| influence of rodent malaria on the course of leishmania enriettii infection of hamsters. | plasmodium yoelii infection was established in hamsters, and the effect of this type of malaria on concurrent leishmania enriettii infection was examined. it was found that the course of the l. enriettii infection was affected by p. yoelii and that this effect depended on the relative timing of the two infections. a chronic malarial infection with plasmodium berghei was also established in hamsters, and this was found to affect the course of a concurrent l. enriettii infection in a similar manne ... | 1976 | 786886 |
| sustained release of an antimalarial drug using a copolymer of glycolic/lactic acid. | | 1976 | 787714 |
| [preparation and biological trials of antimalarial sulfa embonates]. | with the purpose of obtaining salts of sulfonamides with low toxicity but prolonged action, embonates of seven known sulfonamides, with antimalarila activity, were prepared by double exchange reaction between embonic acid and the antimalarial agents. six of the seven embonates prepared showed activity against plasmodium berghei in experimentally infected mice, one of them being significantly more active than the original sulfonamide (sulfadimethoxine). | 1975 | 788077 |
| the chemotherapy of rodent malaria, xxiv. the blood schizontocidal action of erythromycin upon plasmodium berghei. | erythromycin inhibits chloroquine-induced pigment clumping in plasmodium berghei in vitro. the drug was therefore tested against infections of p. berghei in mice and was found to be active at non-toxic doses. given orally, the stearate salt was more effective than the base, but subcutaneously the base was more effective than the stearate. erythromycin potentiated the action of chloroquine against two chloroquine-resistant strains of rodent malaria, the mildly resistant ns, and the highly resista ... | 1976 | 788656 |
| the chemotherapy of rodent malaria, xxv. antimalarial activity of wr 122,455 (a 9-phenanthrenemethanol) in vivo and in vitro. | wr 122,455, 3,6-bis-(trifluoromethyl)-alpha-(2-piperidinyl)-9-phenanthrenemethanol hcl, suppresses infection with drug-sensitive plasmodium berghei n strain in mice. it acts rapidly and affects all the stages of the asexual intraerythrocytic parasites, the effective dose levels being about three times those of chloroquine and one-twelfth to one-fifteenth those of quinine. under the influence of wr 122,455 haemozoin seems to disappear from the affected parasites following an initial coarsening of ... | 1976 | 788657 |
| the chemotherapy of rodent malaria, xxvi. the potential value of wr 122,455 (a 9-phenanthrenemethanol) against drug-resistant malaria parasites. | the phenanthrenemethanol compound wr 122,455 is an effective blood schizontocide against lines of plasmodium berghei that are highly resistant to primaquine, sulphonamides, pyrimethamine and cycloguanil. it is also active against the ns line that is moderately resistant to chloroquine. wr 122,455 is inactive against the rc line which is highly resistant to chloroquine. resistance to wr 122,455 is fairly readily developed by the drug-sensitive n strain of p. berghei, using a relapse technique. r ... | 1976 | 788658 |
| studies on azadiracta indica in malaria [proceedings]. | | 1976 | 788819 |
| plasmodium berghei: osmotic fragility of malaria parasites and mouse host erythrocytes. | | 1976 | 789104 |
| cultivation of the erythrocytic stages of plasmodium berghei in primary bone marrow cells. | cultures of primary bone marrow cells, obtained from the tibiae and femora of hamsters (hbm), mice (mbm), or rats (rbm) were inoculated with red cells infected with plasmodium berghei, p. vinckei vinckei, or p. knowlesi. merozoites, rings, trophozoites, schizonts and a few gametocytes were seen in hbm and mbm cells inoculated with p. berghe-infected red cells. at 1 to 2 or 3 days after inoculation in hbm and mbm, the number of intracellular asexual stages decreased slightly or remained the same, ... | 1976 | 789846 |
| schizont-infected cell enrichment in rodent malaria. | mouse erythrocytes parasitized with plasmodium berghei or plasmodium yoelii were separated by ultracentrifugation using preformed isodensity gradients of the discontinuous type. three fractions were obtained following centrifugation, the upper of which contained greater than 90% of all schizont-infected cells added to the gradient. the gradient material, stractan ii, is an arabinogalactan polysaccharide and appears to yield results similar to those available using gradients of bovine serum album ... | 1976 | 789847 |
| stimulation of resistance in mice to sporozoite-induced plasmodium berghei malaria by injections of avian exoerythrocytic forms. | mice received a series of injections of formalin-killed merozoites (fkm) of exoerythrocytic stages of plasmodium fallax prior to challenge with sporozoites of p. berghei. in one study 4 of 16 fkm-immunized mice never exhibited parasitized erythrocytes after 2 challenges of 10(4) p. berghei sporozoites each, while all control animals died with high parasitemias. fkm-immunized mice were as susceptible as control mice to infections initiated with parasitized erythrocytes. in a second study, 14 of 1 ... | 1976 | 789848 |
| synthesis and properties of mesoionic pyrimido[1,2-b-a1pyridazine-2,4-diones and mesoionic pyridazino[2,3-a-a1-s-trizine-2,4-diones: mesoionic analogs structurally related to fervenulin. | derivatives of two new and unusual classes of heterocycles, possessing structural similarities to the broad spectrum antibiotic fervenulin, were synthesized and examined for in vitro antimicrobial activity. only three of 17 mesoionic pyrimido[1,2-b]pyridazine-2,4-diones exhibited evidence of antimicrobial activity while seven of eight mesoionic pyridazino[2,3-a]-s-triazine-2,4-diones were active against one or more microorganisms. susceptibility toward attack by nucleophiles of both mesoionic py ... | 1976 | 789854 |
| interaction between trypanosoma brucei and plasmodium berghei in concurrent infections in mice. | in conccurrent infection of trypanosoma brucei rhodesiense and plasmodium berghei yoelii in mice, potentiation of one parasite by the other was observed, especially the malaria by the trypanosome infection. the effect appeared early in the infection. it is suggested that the mutual potentiation of the two infections was probably due to immuno-suppression which both organisms are capable of inducing in the host. | 1976 | 789909 |
| [transfusional serology of malaria by an indirect immunofluorescence test using the plasmodium berghei antigen]. | | 1976 | 790519 |
| physiological and morphological characters in two pyrimethamine-resistant lines of plasmodium berghei sp11 after cryopreservation. | the authors describe the characters in two pyrimethamine-resistant lines of plasmodium berghei berghei sp 11-rr after long storage at very low temperatures. in one case the line had maintained its original virulence but lost its resistance to pyrimethamine. gametocytogenesis increased and cyclical transmission was successful. furthermore, parasites crossed the blood-brain barrier and provoked cerebral malaria. in the other case no physiological changes could be detected. the authors conclude tha ... | 1976 | 790672 |
| interaction between protective antibodies and malaria parasites (plasmodium berghei): involvement of low avidity antibodies. | free plasmodium parasites were incubated with a standardized amount of immune serum in a small volume of fluid or a larger one. when these parasites were tested for infectivity in and in vivo test system the parasites incubated in the larger volume of fluid were more infective. other aliquots of free p. berghei parasites were incubated with a standaridzed amount of immune serum and then reincubated with or without dilution of the suspending fluid. those parasites reincubated after dilution were ... | 1976 | 790706 |
| cyclophosphamide pretreatment and protection against malaria. | mice pretreated with cyclophosphamide were able to overcome infection from a lethal malarial strain. the development of resistance was preceded by increased hypersensitivity to malarial antigens. hypersensitivity was demonstrable by a delayed footpad swelling technique. | 1976 | 791863 |
| t cells and protective immunity to plasmodium berghei in rats. | experiments were carried out in which unfractionated spleen cells, and t lymphocyte subpopulations characterized by certain experimental criteria, were isolated at various times from rats infected with plasmodium berghei. by adoptive transfer it was shown that unfractionated spleen cells, and t cells alone, could transfer protection to syngenic recipients as early as 11 days after infection of the cell donors. the protection conferred by t cells increased with the duration of the infection in th ... | 1976 | 791865 |
| cultivation of the erythrocytic stages of plasmodium berghei in leydig cell tumor cultures. | twelve different established cell-lines were used in attempts to cultivate the erythrocytic stages of plasmodium berghei, p. vinckei vinckei, p. coatneyi or p. knowlesi. intracellular parasites were seen in only mouse leydig cell testicular tumor (lct) cultures inoculated with red cells infected with p. berghei. intracellular parasites were present at 15 to 96 h after inoculation, being most numerous at 36 h. most intracellular stages were rings, trophozoites, schizonts and merozoites; gametocyt ... | 1976 | 793226 |
| [comparative morphology by optical and scanning electron microscopy of erythrocytes from mice infected with plasmodium berghei]. | | 1976 | 793494 |
| a comparison of two different methods for the selection of primaquine resistance in plasmodium berghei berghei. | | 1976 | 793547 |
| plasmodium berghei: deep vascular sequestration of young forms in the heart and kidney of the white rat. | | 1976 | 793548 |
| malarial immunodepression in vitro: adherent spleen cells are functionally defective as accessory cells in the response to horse erythrocytes. | the basis for the depressed response of malarial infected mice to horse red blood cells (hrbc) has been studied in vitro. results presented show that the adherent spleen cells from infected mice (a) are defective in their ability to allow nonadherent spleen cells of both normal and infected mice to respond to hrbc whereas a response does occur with adherent spleen cells from normal mice (b) do not suppress the response of unfractionated spleen cells from normal mice to hrbc (c) contain phagocyti ... | 1976 | 793851 |
| surface properties of extracellular malaria parasites: electrophoretic and lectin-binding characteristics. | the surface charge and lectin-binding capacity of isolated malaria parasites and host erythrocytes were analyzed and compared by chromatographic, electrophoretic, and cytochemical methods. results indicated that at physiological ph values both freshly prepared and glutaraldehyde-fixed parasites and erythrocytes possess a net negative surface charge. both cell types were strongly bound to cation-exchange resins and underwent cathode-directed electrophoretic migration. the isoelectric points for e ... | 1976 | 793992 |
| studies on plasmodium ookinetes. 1. isolation and concentration from mosquito midguts. | in a method for isolating a relatively clean suspension of concentrated plasmodium berghei ookinetes from infected midguts of anopheles stephensi at appropriate times after the infective blood meal, the ookinetes are freed from the midguts by enzymatic digestion, and then concentrated by means of a bsa/renografin gradient. the mean number of ookinetes recovered/midgut was 152. more than 95% of the recovered ookinetes were viable by the criteria of motility, incorporation of adenosine and leucine ... | 1976 | 794460 |
| [chemotherapeutically active nitro compounds. 2nd communication: nitrodiphenyl sulfones (author's transl)]. | a number of new 4-nitro-4'-amino-diphenyl sulfones and related compounds were prepared and investigated as to their therapeutic activity. they showed a good systemic activity against tubercle bacilli (m. bovis, nmri mouse) and plasmodia (p. berghei, nmri mouse). the test results reveal that the 4-nitro-4'-amino-diphenyl sulfones possess a spectrum of activity similar to that of diamino-diphenyl sulfone (dds). it is assumed that 4-nitro-4'-amino-diphenyl sulfones in vivo are converted into dds de ... | 1976 | 795435 |
| mouse malaria nephropathy. | mice were infected with 1x 107 plasmodium berghei yoelii parasites intraperitoneally. circulating parasite, malaria antibody and c3 concentrations were measures: parasitaemia and hypocomplementaemia were transient, but the antibody response was persistent. animals were sacrificed at intervals and their kidneys examined: a glomerulonephritis associates with predominantly mesangial deposits of c3, igg1, igm and some iga always developed after 7 days and persisted for up to 6 mth. malaria antigen a ... | 1976 | 796419 |
| suppression of malaria infection by oxidant-sensitive host erythrocytes. | | 1976 | 796730 |
| [absence of transplacental passage in congenital trypanosomiasis in mice with trypanosoma equiperdum. comparison with results obtained in congenital malaria (p.b. berghei) in the same animal]. | | 1976 | 797328 |
| abnormal red cells in the peripheral blood of malarian mouse. | | 1976 | 798563 |
| preliminary studies of artificial immunization of rats against plasmodium berghei and adoptive transfer of this immunity by splenic t and t + b cells. | protective t lymphocyte and t+b lymphocyte responses in rats artificially immunized against p. berghei have been demonstrated by adoptive transfer. the techniques used could be developed for detailed analysis of protective lymphocyte responses generated by various methods of immunization, and their relationship to immunity. | 1976 | 798635 |
| vaccine against malaria in rodents--a preliminary communication. | | 1976 | 798726 |
| [synthesis of quinoline-3- and quinoxaline-2- derivatives and their actions against various malarial parasites]. | | 1976 | 799316 |
| the effects of azadiracta indica in acute plasmodium berghei malaria [proceedings]. | | 1976 | 799404 |
| biological screening in the u.s. army antimalarial drug development program. | the methods of testing drugs in the united states army antimalarial drug development program are described. to date over two hundred thousand compounds have been screened. for each 3,000 compounds evaluated in the primary screen, only 1 is assessed for efficacy in the final test system. of those potential antimalarials assessed in this last system, only about half are deemed worthy of preclinical toxicological evaluation. | 1975 | 804264 |
| pyruvate kinase in malaria host-parasite interaction. | | 1975 | 805379 |
| orally-administered silver sulfadiazine: chemotherapy and toxicology in cf-1 mice; plasmodium berghei (malaria) and pseudomonas aeruginosa. | silver sulfadiazine when administered orally and subcutaneously to cf-1 mice in doses not exceeding 1,050 mg/kg proved to have minimal toxicity. no pathology or abnormal reactions were seen in cf-1 mice after receiving 1,050 mg/kg orally and subcutaneously once a day for 30 days. silver sulfadiazine in doses of 1,050 mg/kg, once a day for 5 days cured mice of plasmodium berghei even after splenectomy. parasitemia was reduced to zero in 1-3 days and antimalarial activity was not inhibited signifi ... | 1975 | 807459 |
| amino acid analogs. iii: new syntheses of monomethyl- and monophenylglutamic acids. | glutamic acid analogs containing 3- and 4-methyl and 2-, 3-, and 4-phenyl substituents were prepared. the 3- and 4-methyl- and 3- and 4-phenylglutamic acids did not inhibit plasmodium berghei and were nontoxic to the host (mice) at 640 mg/kg. the five analogs in addition to 2-methlglutamic acid were inactive against lactobacillus casei at 1000 mug/ml in a defined medium: against escherichia coli, only 2-methylglutamic acid caused 27% inhibition at 10,000 mug/ml. all six analogs failed to inhibit ... | 1975 | 811786 |
| quinazolines as inhibitors of dihydrofolate reductase. 3. analogs of pteroic and isopteroic acids. | a series of 19 quinazoline analogs of pteroic and isopteroic acid was prepared with particular emphasis being placed upon carboxylic acid esters. each compound was evaluated as an inhibitor of the dihydrofolate reductases from rat liver as well as from streptococcus faecium. several of the more potent inhibitors were found to be inactive against l1210 leukemia in mice at low dose levels and were lethal to mice at 100 mg/kg. six compounds were also evaluated for antimalarial activity against plas ... | 1975 | 811798 |
| the search for new antimalarial drugs. | | 1975 | 813015 |
| antibody-induced ultrastructural changes of malarial sporozoites. | immunization with irradiated sporozoites produces a considerable degree protection against rodent, simian, and human malaria. this protection is in part antibody mediated. antibodies neutralize sporozoites (sna), i.e. abolish their infectivity, and cause, in vitro, the formation of a thread-like precipitate on the parasites (csp reaction). the present study was undertaken to characterize the ultrastructural aspects of antibody-sporozoite interaction. | 1976 | 815435 |
| complement alterations in rodent malaria. | in the course of rodent malaria, the ability of mouse serum to release immune complexes from lymphocytes (complex-release, or cra), a complement dependent function, becomes profoundly altered. these alterations occur in parallel with changes in the serum levels of the third complement component (c3). a transitory but significant increase in cra and c3 was noticed during the first 3 days after blood-induced plasmodium berghei infection. this was followed by a progressive decrease in cra, which wa ... | 1976 | 816212 |
| effect of vitamin a and undernutrition on the susceptibility of rodents to a malarial parasite plasmodium berghei. | the ability of vitamin a deficient rats to resist infection with p. berghei was investigated. when 10 x 10(6) erythrocytes bearing the parasite/100 g body weight were given to the vitamin a protein energy undernourished rats, parasitemia developed in these animals at a faster pace than the controls. a high number (60% to 95%) of red blood cells (rbc) carrying the parasite were noticeable within 6 to 7 days after infection, at which time most animals in this group died. the pair-fed controls (pro ... | 1976 | 818347 |
| [increased non-specific resistance to induction of malaria by sporozoites of plasmodium berghei yoëlii in mice pretreated with a bacterial phospholipid extract]. | the injection of a bacterial phosphospholipid extract increases resistance of mice subsequently challenged with sporozoïtes of plasmodium berghei yoëlii. the pretreatment consisted of one injection of a suspension containing various amounts of phospholipid extract. it was e-fective when it shortly preceded the sporozoïtes inoculation. this resulted in total protection of a great number of animals against various amounts of sporozoïtes. there was a correlation between the dose of ebp injected and ... | 1975 | 819147 |
| 5-aryloxy-6-methoxy-8-aminoquinolines as potential prophylactic antimalarials. | 5-(p-anisyloxy)-6-methoxy-8-(5-isopropylaminopentylamino)quinoline was resynthesized for evaluation in the plasmodium berghei and monkey prophylactic (plasmodium cynomolgi) tests. a new primary amine, three secondary amines, and one structurally modified side-chain analog of the 5-aryloxy series were also prepared. none of these compounds showed significant antimalarial or prophylactic activity. | 1976 | 824437 |
| reduced 8-aminoquinoline analogues as potential antimalarial agents. | the synthesis of 1-alkyl-8-(aminoalkylamino)-6-methyl1-1,2,3,4-tetrahydroquinolines, 8-(4'-amino-1'-methylbutylamino)-6-methoxy-1-methyl1-1,2-dihydroquinoline, 5-substituted 8-(4'-amino-1'-methylbutylamino)-1-methyl-1,2-dihydroquinolines, 8-alkylamino-1-(2-n,n-diethylaminoethyl)-6-methoxy-1,2,3,4-tetrahydroquinolines, 1-)2-n,n-diethylaminoethyl)-6-methoxy-1,2,3,4-tetrahydroquinoline, 1-(2-n,n-diethylaminoethyl)-8-(2-n,n-diethylaminoethylamino)-6-methoxy-1,2,3,4-tetrahydroquinoline, and 2-substit ... | 1976 | 824447 |
| survival of aegyptianella pullorum, anaplasma marginale and various parasitic protozoa following prolonged storage in liquid nitrogen. | various protozoa species were examined using in vivo and in vitro methods to determine their ability to survive prolonged periods of storage in liquid nitrogen. the following protozoan species were successfully recovered after they had been cryopreserved for a period over 10 years: trypanosoma lewisi, t. cruzi, t. congolense, t. brucei, t. rhodesiense, t. gambiense, t. evansi, t. equinum, t. equiperdum, leishmania donovani, plasmodium berghei, p. praecox (relictum), babesia rodhaini and b. canis ... | 1977 | 919686 |
| structure of aplasmomycin. | a new antibiotic, aplasmomycin, was isolated from a broth cultivated with a marine isolate of actinomycete, and inhibits gram-positive bacteria in vitro and plasmodium berghei in vivo. it is a natural ionophore and the structure of the ag-salt was solved by an x-ray crystallographic analysis. it has symmetric structure having boron in the centre of the molecule. | 1977 | 924893 |
| inhibition of macromolecular synthesis in the malarial parasites by inhibitors of proteolytic enzymes. | | 1975 | 1089545 |
| motility of plasmodium berghei ookinetes in vitro. | | 1975 | 1089734 |
| plasmodium berghei: thyroid hyperplasia and thyroid hyperactivity in mice. | | 1975 | 1090441 |
| regional immunosuppression induced by plasmodium berghei yoelii infection in mice. | plasmodium berghei yoelii infection in mice severely depressed the splenic antibody response to sheep erythrocytes but had lettle effect on antibody formation in lymph nodes. | 1975 | 1090525 |
| the in vitro culture of the blood stages of plasmodium berghei. | | 1975 | 1090550 |
| humoral immunity in rodent malaria. iii: studies on the site of antibody action. | serum which protects rats against plasmodium berghei infections fails to sensitize parasitized erythrocytes in vitro for in vivo destruction. further, the efflux of 86rb from parasitized erythrocytes in the presence of complement is not accelerated. on administration to animals with preexisting malaria, it does, however, produce a relatively slow decline in parasitemia, a phenomenon interpreted in terms of the gradual production and/or release of reactive antigenic determinants associated with m ... | 1975 | 1090670 |
| development of infectivity by the plasmodium berghei sporozoite. | studies were done on the development of infectivity during ontogeny of the sporozoite of the rodent malaria parasite, plasmodium berghei. populations of sporozoites were separated from the oocysts, the hemocoel, and the salivary glands, with special precautions being taken to avoid cross-contamination between the different populations. the results indicated that populations of salivary gland sporozoites were more than 10,000 times as infective as populations of oocyst sporozoites from the same m ... | 1975 | 1090717 |
| rodent systems (plasmodium berghei-anopheles stephensi) for screening compounds for potential causal prophylaxis. | an in vivo screening system is described in which drugs administered to rats or mice and challenged with sporozoites are evaluated for their antimalarial properties (causal prophylaxis, suppression, therapy) by the presence or absence of exoerythrocytic forms and parasitemia. the system is composed of a/j mice, sprague-dawley rats, plasmodium berghei, and anopheles stephensi. good correlation has been found between test results and practical application. | 1975 | 1091166 |
| detailed purine salvage metabolism in and outside the free malarial parasite. | | 1975 | 1091492 |
| qualitative analysis of phospholipids isolated from nonviable plasmodium antigen. | | 1975 | 1091493 |
| a new prodiginne (prodigiosin-like) pigment from streptomyces. antimalarial activity of several prodiginnes. | two prodigiosin-like pigments from streptomyces sp. were shown to be undecylprodiginine (i) and butylcycloheptylprodiginine (v). the antimalarial activity of five prodiginine pigments is given. | 1975 | 1092639 |
| synthesis and antimalarial activity of heterocyclic alkyl disulfides, thiosulfates, and dithio acid derivatives. | based on the antimalarial activity in mice of bis(4-rho-acetamidobenzenesulfonamidophenyl) disulfide, a series of n-heterocyclic alkyl disulfides and thiosulfates was synthesized and screened for antimalarial activity. several related dithio acid dianions and s- blocked derivatives were also screened to provide an indication of the possible role that thiol anions might play in malaria chemotherapy. activity was limited by toxicity with these compounds, and none of those tested, with the exceptio ... | 1975 | 1092835 |
| synthesis and evaluation of 6-arylactamido-2,4-diaminoquinazolines and related compounds as folic acid antagonists. | a series of 2,4-diaminoquinazolines bearing an aryl function attached to the 6 position through an acetamido or related linkage was synthesized. each compound was evaluated as an inhibitor of rat liver dihydrofolate reductase as well as for suppressive antimalarial effects against plasmodium berghei in mice. significant in vivo activity was found to reside primarily with 5-chloro-6-arylacetamido derivatives. most of these compounds were also tested for prophylactic activity against sporozoite-in ... | 1975 | 1094114 |
| circadian and other rhythms of parasites. | | 1975 | 1094812 |
| splenic mediated erythrocyte cytotoxicity in malaria. | cell-mediated cytotoxicity in virulent rodent malaria has been demonstrated in vitro, whereby splenic cells effected specific lysis of 51cr-labelled erythrocytes from parasitized animals. more than one cellular cytolytic effector system appeared to be operative in the mouse. one effector system involved splenic macrophages, from normal or immune animals, which were increasingly cytotoxic to target cells in the presence of antibody. a second effector system involved nylonpurified immune spleen ce ... | 1975 | 1095474 |
| antimalarial compounds. xiii. new derivatives of phenyl chloromethyl sulfone. | a series of chloromethylsulfonyl derivatives of amines, biguanides and amidineureas (scheme 1) has been prepared and their antimalarial properties investigated. | 1975 | 1096101 |
| antimalarial compounds. xiv. new derivatives of 2-bromo-n,n-bis-(diethylaminoethyl)-4,5-dimethoxyanaline (rc 12). | the molecule of rc 12 which was found previously to exhibit antimalarial activity has been modified, by replacing groups in positions 1 and 2 by nhar, s-ar, no2, sulfonamido and other substituents. the new derivatives (table 1) were tested for toxicity and antimalarial activity agains plasmodium berghei in mice (table 2). | 1975 | 1096102 |
| cerebral malaria in a virulent rodent plasmodial infection. | | 1975 | 1096377 |
| anaemia in mice with concomitant schistosoma mansoni and plasmodium berghei yoelii infection. | 1. the effect on anaemia in mice given plasmodium berghei yoelii 3 and 5 weeks after exposure to schistosoma mansoni cercariae, was investigated. 2. haematological criteria (pcv and haemoglobin levels), reticulocytosis, parasitaemia and splenomegaly were used as indices. 3. anaemia was severe in the animals given p. b. yoelii and in those with mixed infection (p. b: yoelii plus s. mansoni). malaria was found to dominate the picture until the clearance of the parasitaemia. the effect of the inter ... | 1975 | 1096378 |
| counter-current immunoelectrophoresis for the demonstration of malarial antigens and antibodies in the sera of rats and mice. | | 1975 | 1096380 |
| plasmodium berghei: immunologic enhancement of antigen by adjuvant addition. | | 1975 | 1097263 |
| antibody-mediated elimination of malaria parasites (plasmodium berghei) in vivo. | an infective preparation of extracellular blood forms (fp) of plasmodium berghei was used to study some aspects of the interaction between protective antibodies and malaria parasites. fp but not infected erythrocytes (irbc) were shown by the fluorescent antibody technique to be coated by antibodies after in vitro incubation with immune serum. preincubation of both fp and irbc with immune serum followed by their washing did not result in enhanced elimination of the parasites in vivo. however, fp ... | 1975 | 1097338 |
| synthesis of (4-quinolinoamino)aminoalkyltetrahydronaphthalene derivatives for possible antimalarial activity. | (4-quinolinoamino)aminoalkyltetrahydronaphthalene derivatives were synthesized in an attempt to introduce new agents with antimalarial activity. | 1975 | 1097633 |
| potential antimalarials. 9. resolution of alpha-diheptylaminomethyl-6-bromo-9-phenanthrenemethanol by an unusual method. | | 1975 | 1097687 |
| quinoxaline studies. 23. potential antimalarials. substituted 5,8-dimethoxyquinoxalines. | two series of 2,3-disubstituted 5,8-dimethoxy-6-[n- (omega-dimethylaminoalkyl) amino] quinoxalines were prepared: the first series with identical 2,3-substituents h, ch3, c6h5, c6h4-4-cl, and ch2c6h5; and the second with identical styryl groups ch=chc6h5, ch=chc6h4-4-cl, ch=chc6h3-3,4-c12, ch=chc6h4-4-f, ch=chc6h4-4-cf3, and ch=chc6h4-4-no2. none of the substances possessed antimalarial activity; several were toxic at highest dosage levels. | 1975 | 1097693 |
| the chemotherapy of rodent malaria, xxi. action of quinine and wr 122 (a 9-phenanthrenemethanol) on the fine structure of plasmodium berghei in mouse blood. | the effects of quinine and a 9-phenanthrenemethanol, wr 122,455 on the fine structure of plasmodium berghei have been investigated. changes consequent upon quinine treatment were noted in the outer membranes (including those that surround the "food vacuole") and the digestive vacuoles. these changes were followed by cytoplasmic degeneration and vacuolization. wr 122,455 caused morphological changes in at least three areas of the parasite, (1) the outer membranes, (2) the digestive vacuole and (3 ... | 1975 | 1098583 |
| the chemotherapy of rodent malaria, xxii. the value of drug-resistant strains of p. berghei in screening for blood schizontocidal activity. | data are provided on the activity of a variety of antimalarial drugs against drug-sensitive and drug-resistant lines of plasmodium berghei in albino mice. parallel data for the response of the drug-sensitive parasites to these compounds in vitro indicate whether the drugs have a chloroquine-like or quinine-like type of action, or neither. the value of this test system for drug evaluation is debated. it is concluded that the in vivo tests do provide a valuable indication of the potential use of a ... | 1975 | 1098584 |
| sudden increase in virulence in a strain of plasmodium berghei yoelii. | the mild and chronic 17x strain of plasmodium berghei yoelii showed a sudden increase in virulence following a period of 110 days in the deep freeze. the enhanced virulence was seen in a very high and early parasite peak in the blood and a 100% mortality of all infected mice. the exalted virulence remained unaltered following a number of blood transfers of the strain and after four cyclical transmissions through anopheles stephensi. enzyme pattern studies revealed that the virulent strain posses ... | 1975 | 1098585 |
| role of complement components in the susceptibility to plasmodium berghei infection among inbred strains of mice. | inbred strains of mice, sensitive and resistant to plasmodium berghei infections, including a complement deficient strain were infected with p. berghei. daily levels of parasitaemia were determined and serum levels of complement components (c3 and c5) measured by standard haemolytic assay. serum levels of c3 and c5 were depressed in all strains of mice infected with p. berghei. there was no difference in the infectivity and course of p. berghei infection in the co-isogenic c5 deficient and non-d ... | 1975 | 1098586 |
| purification and some properties of malarial pigment. | malarial pigment from erythrocytes infected with plasmodium berghei was purified by treatment with sodium dodecyl sulphate solution, followed by incubation with pancreatin. the purified pigment retained the apparently crystalline form of pigment within the parasite, rotated polarised light and had the same solubility characterisation as crude malarial pigment. it contained about 1% iron, all of which could be accounted for in terms of haemin. the iron of the pigment molecule is oxidised by the p ... | 1975 | 1098588 |
| immunological studies in rodent malaria. i: protective immunity induced in mice by mild strains of plasmodium berghei yoelii against a virulent and fatal line of this plasmodium. | mild and virulent lines of plasmodium berghei yoelii are readily distinguished both by their course of infection and by the preference of the virulent line for mature red blood cells. mice given either mild line were fully protected against the virulent p.b. yoelii one week after they had become negative. mice given the mild line of p.b. yoelii 17x were fully protected against a challenge by the virulent line on the third day of infection (d+3). mice given the mild and virulent lines of p.b. yoe ... | 1975 | 1098589 |