| influence of the sex-linked defect in cba/n mice on autoimmune responses to isologous erythrocytes. ability to overcome the defect with age. | normal mice spontaneously develop plaque-forming cells (pfc) specific for antigens on modified self erythrocytes (bromelain-treated mouse erythrocytes [brmrbc] antigens). our study demonstrates that the sex-linked defect that results in the inability of cba/n mice to respond to several t-independent antigens (ti-2 antigens) also regulates the autoantibody response to brmrbc antigens. thus, in cba/n homozygous mice and male f1 offspring of cba/n-mothered crosses, e.g., (cba/n x nzb)f1 males, such ... | 1979 | 315995 |
| use of drugs for malaria control in tropical africa. | at present, in countries of tropical africa, chemotherapy is the main and often the only operationally, administratively, and financially feasible method of malaria control. this applies particularly in rural areas. this article reviews experience with chemotherapy in africa since the late 1940s with mepacrine, proguanil, pyrimethamine, chloroquine, amodiaquine, and sulfones and sulfonamides in combination with dihydrofolate reductase inhibitors. chloroquine has proved to be the most effective c ... | 1979 | 316734 |
| the orientation of immunological research in relation to the global antimalaria programme. | immunological research on malaria has produced a wealth of information on the relationship between plasmodium and the vertebrate host, introducing new serological tools into epidemiological methodology and experimentally proving the possibility of protecting vertebrates against malaria, thus moving vaccination from the realm of pure hypothesis to the level of feasibility.the alarming malaria situation in the world is reason enough to expand immunological research further to improve diagnostic an ... | 1979 | 317437 |
| the possible role of isoantigens in protective immunity to malaria. | the possibility that autoimmune responses to modified red cell antigens might be involved in protective immunity to malaria was investigated in plasmodium berghei infection of august rats. animals rendered anaemic by phenylhydrazine treatment at the time of immunization showed significantly greater protection than rats given antigen alone, or phenylhydrazine alone. adoptive transfer experiments indicated that this enhanced response could be transferred with spleen cells. | 1979 | 317438 |
| metrizamide density gradients for separation of different developmental stages of malarial parasites. | density gradients with metrizamide, a tri-iodinated benzamido derivative of glucose, have been used to separate erythrocytes infected with three species of murine plasmodia. uninfected erythrocytes separated well from erythrocytes containing parasites in different developmental stages. with metrizamide solutions, the densities required for isopyknic separation can be obtained without hypertonicity or high viscosity, and the viability and metabolism of parasites and erythrocytes are not detectabl ... | 1979 | 317440 |
| malaria infections in different strains of mice and their correlation with natural killer activity. | different mouse strains show marked variation in susceptibility to murine malaria parasites. of those studied, strain a mice showed the highest susceptibility, most animals dying from plasmodium chabaudi infections. in contrast, c57bl and cba mice all recovered from p. chabaudi infections and were then resistant to challenge with a virulent strain of p. yoelii. balb/c mice recovered from p. chabaudi infections but were not uniformly resistant to p. yoelii challenge. b10.a mice, which share haplo ... | 1979 | 317441 |
| cellular aspects of immunoregulation in malaria. | malaria infection dramatically induces two nonspecific perturbations in immune responsiveness, polyclonal b cell activation and immunosuppression. polyclonal activation occurs early in infection and results in secretion of antibodies that lack antiplasmodial specificity. immunosuppression occurs later in infection and is characterized by blunted humoral and cellular immune responses to heterologous (nonplasmodial) as well as plasmodial antigens. previous studies have suggested that defects in ma ... | 1979 | 317442 |
| lethal plasmodium yoelii malaria: the role of macrophages in normal and immunized mice. | mice were injected with silica or corynebacterium parvum, which, respectively, inhibit and stimulate macrophages in vivo, in an attempt to study the role of macrophages in lethal plasmodium yoelii infection and in mice protected by immunization. in the normal infection, macrophages were able to control parasitaemia for up to 1 week, whereas in immunized mice they appeared to inhibit the sterilizing immune response. a model is proposed in which this dual role of activated macrophages may account ... | 1979 | 317443 |
| immunity to plasmodium yoelii and babesia microti: modulation by the cba/n x-chromosome. | cba/n mice carry an x-linked recessive defect expressed in cells of the b cell lineage. the major deficiency in these mice is an almost complete inability to respond to certain thymus-independent antigens, such as pneumococcal polysaccharide type iii (s iii). we have examined the responses of mice carrying the cba/n x-chromosome to the malaria parasite plasmodium yoelii and the piroplasm babesia microti. we have found that the duration and severity of these infections is increased in mice carryi ... | 1979 | 317444 |
| alterations in membrane proteins of mouse erythrocytes infected with different species and strains of malaria parasites. | 1. the membrane fraction, prepared by hypotonic lysis, of mouse red cells infected with plasmodium berghei, p. yoelii ym, p. yoelii 17 x, p. yoelii 33 x, p. vinckei or p. chabaudi shows significant alterations from normal in protein composition as observed by dodecylsulphate-polyacrylamide gel electrophoresis. 2. there is a reduction in intensity of various protein bands, notably bands i and ii (spectrin), of membranes prepared from infected red cells. 3. new bands are observed as a result of in ... | 1979 | 318403 |
| chemoprophylaxis of malaria. | | 1977 | 318895 |
| ca++ regulation in caffeine-derived microplasmodia of physarum polycephalum. | caffeine-derived microplasmodia possess a ca++-sequestering system which can initiate motility. the experiments presented here suggest that this system is membranous and nonmitochondrial in nature. therefore, it is proposed that the shuttle streaming in the plasmodium is controlled by the localized release and uptake of free ca++ from an intracellular storage system analogous to the sarcoplasmic reticulum. | 1977 | 319101 |
| conformational studies of a family of related antimalarial phenanthrene amino alcohols. | a conformational study utilizing quantum chemical methods was performed on a family of antimalarial alpha-(piperidyl)-3,6-bis(trifluoromethyl)-9-phenanthrenemethanols whose structures differ by the placement of the substituent on either the 2,3, or 4 position of the piperidyl ring. the antimalarial activity of these 3-substituted compounds has been shown experimentally to be highly stereospecific while the 2-substituted compounds are not and the 4-substituted compounds are inactive. in this stud ... | 1977 | 319232 |
| where are you going. | | 1977 | 319727 |
| plasmodium vivax: correlation of circumsporozoite precipitation (csp) reaction with sporozoite-induced protective immunity in man. | | 1977 | 320027 |
| plasmodium berghei: polyribosome profiles in the spleens of infected mice. | | 1977 | 320032 |
| chloroquine-resistant falciparum malaria from papua new guinea and its implications for australia. | there is need for effective chemoprophylaxis against chloroquine-resistant falciparum malaria, and for a safe and effective drug to be readily available for the treatment of that condition. experience with the cases cited in this study indicates that fansidar should be made available for treatment and it is suggested that maloprim be made available as a prophylactic agent. | 1977 | 320435 |
| plasmodium falciparum gametocytes: their longevity and infectivity. | the longevity and infectivity of isolated populations of plasmodium falciparum gametocytes were studied. following chloroquine treatment gametocyte numbers fell with a constant rate of loss over a period of 16-24 days; the populations had a half-life of 2-4 days. the sex ratio stayed constant throughout at 4 female: 1 male. the ability of the microgametocytes to exflagellate and the infectivity of the population to mosquitoes persisted for 3 weeks. antibodies to the gametocytes were detected but ... | 1977 | 320542 |
| protection of mice against babesia spp. and plasmodium spp. with killed corynebacterium parvum. | mice which had been pre-treated with killed corynebacterium parvum given intravenously or intraperitoneally, but not subcutaneously, were completely resistant to infection with babesia microti or b. rodhaini, and were protected from death caused by plasmodium vinckei or p. chabaudi infection. there is evidence that the parasites died within circulating erythrocytes. this occurred much too soon for a specific antibody response to be evoked, and no antibody could be detected by the indirect fluore ... | 1977 | 320544 |
| a strain of plasmodium vivax characterized by prolonged incubation: the effect of numbers of sporozoites on the length of the prepatent period. | the north korean strain of plasmodium vivax was characterized by its extraordinarily prolonged incubation period in certain circumstances. it was clearly demonstrated by quantitative observations that the phenomenon may be elicited by the inoculation of small numbers of sporozoites. after the intradermal inoculation of 10 or 100 sporozoites, the incubation period was delayed for periods varying between 262 and 628 days; after u,000 sporozoites, with one exception, the same delay occurred; after ... | 1976 | 320726 |
| prepatent periods of a tropical strain of plasmodium vivax after inoculations of tenfold dilutions of sporozoites. | eleven patients requiring malaria therapy were inoculated intradermally with graded doses of sporozoites of the chesson strain of plasmodium vivax. estimated doses of 10 sporozoites were given to four patients, of 100 to three patients, of 1,000 to two patients, and of 10,000 to two patients. parasitaemia was detected in all patients 12 to 17 days after inoculation; fever began on the 14th to 19th days. the results of the trials are compared with earlier work on a temperate strain of p. vivax in ... | 1976 | 320727 |
| non-antibody factor(s) in adult serum decreases the infectivity of plasmodium berghei. | | 1976 | 320729 |
| chloroquine resistant plasmodium falciparum in bangladesh. | | 1976 | 320730 |
| prevention and treatment of malaria. | | 1977 | 320732 |
| an outbreak of introduced malaria in california possibly involving secondary transmission. | during 1974, 12 cases of plasmodium vivax malaria were reported from an agricultural area in california's sacramento valley. at least three of these cases resulted from local mosquito transmission. the imported cases were in punjabi immigrants except for one in an american-born visitor to the punjab. this is the 11th reported outbreak of introduced malaria in the united states since 1952, and the first in california since 1957. a unique aspect of this outbreak is the likelihood that secondary tr ... | 1977 | 320891 |
| malarial lung: report of a case from africa successfully treated with intermittent positive pressure ventilation. | we describe the first recorded case from africa of malarial lung, acute pulmonary insufficiency in plasmodium falciparum malaria. the patient was successfully treated with intermittent positive pressure ventilation (ippv). there was heavy parasitemia, preceding cerebral complications and rapid onset of pulmonary edema in the absence of fluid overload or cardiac failure. a further complication of polyuria from tubular dysfunction developed whilst the patient was being ventilated. ippv may have an ... | 1977 | 320893 |
| immunity to sporozoite-induced malaria infeciton in mice. i. the effect of immunization of t and b cell-deficient mice. | the cellular basis of immunity to sporozoites was investigated by examing the effect of immunization of t and b cell-deficient c57bl/6n x balb/c ann f1 (blcf1) mice compared to immunocompetent controls. immunization of t cell-deficient (atx-bm-ats) blcf1 mice with x-irradiated sporozoites did not result in the generation of protective immunity. the same immunization protocols protected all immunocompetent controls. in contrast, b cell-deficient (micron-suppressed) blcf1 mice were protected by im ... | 1977 | 321689 |
| synthesis of sulfonates of 4-chloro-3,5-dimethylphenol and 5-chloro-7-iodo-8-quinolinol. | | 1977 | 321753 |
| synthesis and antiprotozoal activity of 2,5-bis(4-guanylphenyl)furans. | eighteen substituted 2,5-bis(4-guanylphenyl)furans and related analogues, including "masked" amidines in which the guanyl function is incorporated into a heterocyclic ring, have been synthesized and their antimalarial and antitrypanosomal activity has been evaluated. none of the compounds exhibited high orders of antimalarial activity; however, 11 were very active against trypanosoma rhodesiense in mice. six compounds, including 2,5-bis(4-guanylphenyl)furan (4) and its 3-chloro (32), 3,4-dichlor ... | 1977 | 321783 |
| linkage of chloroquine resistance in plasmodium berghei to infection of immature erythrocytes of mice. | | 1977 | 321904 |
| chloroquine-resistant plasmodium falciparum and malaria in africa. | | 1977 | 324040 |
| cultivation of plasmodium falciparum. | | 1977 | 324435 |
| plasmodium berghei: immunization of mice against the anka strain using the unaltered sporozoite as an antigen. | | 1977 | 324783 |
| plasmodium berghei: quantitation of sporozoites injected by mosquitoes feeding on a rodent host. | | 1977 | 324786 |
| plasmodium berghei: selective release of "protective" antigens. | | 1977 | 324787 |
| plasmodium berghei: immunosuppression and hyperimmunoglobulinemia. | | 1977 | 324788 |
| plasmodium berghei: t cell dependence of sporozoite-induced immunity in rodents. | | 1977 | 324789 |
| reactivity and crossreactivity of mouse helper t cells to malaria parasites. | the mouse helper t-cell response to four plasmodial and babesial parasites was measured by using them as carriers for a standard hapten (tnp). helper t cells appeared to recognize all the parasites, but not to be able to distinguish between them. helper t-cell responses could be augmented by vaccination with formalin-fixed parasites. however vaccination did not always confer protection against infection. conversely, mice resistant to infection because of prior recovery from a homologous or heter ... | 1977 | 324898 |
| antibody response in vitro of spleen cells from plasmodium yoelii-infected mice. | the primary antibody response to sheep erythrocytes and dinitrophenylated ficoll of spleen cells from mice infected with plasmodium yoelii was studied in vitro. the response to sheep erythrocytes was enhanced between 2 and 4 days after infection and depressed at later intervals. cell fractionation experiments carried out at the time of immunosuppression indicated a defect of macrophage function. at the same time the response to dinitrophenylated ficoll was normal. | 1977 | 324908 |
| time-dependent loss of invasive ability of plasmodium berghei merozoites in vitro. | the invasive ability of plasmodium berghei merozoites in vivo was studied following their artificial removal from parasitized mouse red cells using complement-mediated immune lysis in vitro and in vivo. time-course experiments revealed that lysed preparations contained two components contributing to the parasites' infectivity in mice. one component, presumed to be free merozoites released from mature schizont-infected cells, rapidly lost infectivity with time at 1 to 2 c. a second minor componen ... | 1977 | 325188 |
| fatty acid-free bovine albumin as plasma replacement for in vitro cultivation of plasmodium falciparum. | | 1977 | 325190 |
| [malaria infection in patients with sickle cell anemia]. | | 1977 | 325541 |
| pancreatitis complicating falciparum malaria. | | 1977 | 325545 |
| [clinical aspects of malaria]. | | 1977 | 325645 |
| delayed immune reactions in mice immunized with malarial antigen. | mice were immunized subcutaneously, intravenously or in a footpad with antigens prepared from a lethal strain of plasmodium berghei yoelii. a delayed footpad swelling (dfs) reaction was observed 4 days after immunization, and was detectable at least 42 days after immunization. however, iv immunization was the least efficacious is producing hypersensitivity. regardless of the type of antigen used for immunization, mice responded similarly when live parasites were used to elicit dfs. this study re ... | 1977 | 326066 |
| radical cure of chesson strain vivax malaria in man by 7, not 14, days of treatment with primaquine. | glucose-6-phosphate dehydrogenase-normal adult volunteers infected with mosquito-bone chesson strain vivax malaria were treated with chloroquine and primaquine during the initial attack. administration of 60 mg (base) of primaquine daily for 7 days was as effective in preventing relapse as is the regimen customarily used for the radical cure of infections produced by this strain, namely, 30 mg daily for 14 days. however, it is stressed that because of the risk of primaquine-induced hemolysis in ... | 1977 | 326072 |
| experimental studies of the potentiation of proguanil and pyrimethamine by dapsone using plasmodium berghei in white mice. | an accurate system with stringent criteria has been established to test antimalarial drugs and drug combinations against plasmodium berghei in mice. minimum effective doses for a number of antimalarial drugs have been determined when used in this system. considerable potentiation of the activity of pyrimethamine and to a somewhat less extent of proguanil by dapsone has been demonstrated. the need to extend studies of these combinations to the parasites of human malaria is discussed in terms of e ... | 1977 | 326205 |
| chemoprophylaxis of malaria. | | 1977 | 326335 |
| sequential treatment with quinine and mefloquine or quinine and pyrimethamine-sulfadoxine for falciparum malaria. | patients with falciparum malaria were studied in thailand, an area of known chloroquine resistance. the patients were unselected and some had severe malaria, and they were randomly assigned to one of two sequential regimes. a short course of quinine (average 4 doses, equivalent to 2 g base) followed by a single dose of pyrimethamine-sulfadoxine (fansidar) cured 92% of patients (36 out of 39), while a short course of quinine followed by a single 1-5-dose of mefloquine cured all of the 35 patients ... | 1977 | 326337 |
| erythrocyte membrane-associated immunoglobulins during malaria infection of mice. | immunoglobulin (ig) is associated with erythrocyte membranes during infection of a/j mice with plasmodium berghei. it was detected by agglutination of the cells with rabbit antibodies to mouse igg and by a radioimmunoassay with 125i-labelled rabbit antibodies to mouse igg. as shown by the degree of agglutination and of binding of radiolabeled antibodies to the erythrocyte membranes, the amount of ig increased with time after infection and paralleled parasitemia and reticulocytosis. the erythrocy ... | 1977 | 326956 |
| evidence for differences in erythrocyte surface receptors for the malarial parasites, plasmodium falciparum and plasmodium knowlesi. | human erythrocytes lacking various blood group determinants were susceptible to invasion by plasmodium falciparum including duffy-negative erythrocytes that are refractory to invasion by plasmodium knowlesi. erythrocytes treated with trypsin or neuraminidase had reduced susceptibility of p. falciparum and normal susceptibility to p. knowlesi. chymotrypsin treatment (0.1 mg/ml) blocked invasion only by p. knowlesi. the differential effect of enzymatic cleavage of determinats from the erythrocyte ... | 1977 | 327014 |
| [transmission of the brazilian strain of tertian malaria by anopheles maculipennis atroparvus mosquitoes]. | | 1977 | 327252 |
| [a patient with high fever]. | | 1977 | 327338 |
| [chloroquine resistant tropical malaria imported from surinam]. | | 1977 | 327340 |
| malaria field studies in a high-incidence coastal area of el salvador, c.a. | a three-year investigation was made of the incidence patterns and characteristics of malaria in a small high-incidence coastal area of el salvador with a resident population of about 6,000 persons and a migrant population of 3,000 to 4,000 others. it found a significant increase in the incidence of plasmodium falciparum cases during the three-year period, combined with relative stability in the annual number of plasmodium vivax cases. a close correlation was observed between the seasonal occuren ... | 1977 | 328096 |
| malaria and hereditary ovalocytosis. | hereditary ovalocytosis in papua new guinea is restricted to areas of endemic malaria and may confer increased resistance to the disease. the incidence of malaria was investigated in 1616 melanesiams of known red cell morphology and severity of infection determined in a smaller subsample. ovalocytics tended to be more resistant to severe malarial infections than normocytics. the ratio of parasitaemia in 112 ovalocytics compared with 741 normocytic children was 1.05 for p. falciparum; 0.90 for p. ... | 1977 | 328370 |
| the immunological response of cba mice to p. yoelii. i. general characteristics, the effects of t-cell deprivation and reconstitution with thymus grafts. | experimental infection of normal cba mice with the parasite plasmodium berghei yoelii (p. yoelii) resulted in a mild, non-fatal and self-limiting infection which lasted for 15-17 days. animals which recovered from the primary infection were immune to reinfection though parasites could be detected in the kidneys of such mice 4 weeks after recovery from infection. (no plasmodia were demonstrated in the peripheral blood and other tissues examined.) in t cell-deprived mice, p. yoelii infections resu ... | 1977 | 328382 |
| cerebral malaria. | cerebral malaria is an unusual and treatable cause of stupor and coma, and it can present suddenly in a healthy person. it is diagnosed by finding parasites on a blood smear and is treated either with chloroquine or with quinine, pyrimethamine, and sulfadiazine. | 1977 | 328970 |
| imported malaria in europe. | | 1977 | 329079 |
| the prevention and treatment of malaria. | | 1977 | 329080 |
| congenital malaria: a rare cause of splenomegaly and anemia in an american infant. | a 38-day-old infant had fever, jaundice, hepatosplenomegaly, and a hemolytic anemia. a peripheral blood smear demonstrated intraerythrocytic malarial parasites identified as plasmodium vivax. maternal and infant sera contained antibodies to this species. a directed history revealed the mother had suffered several febrile illnesses in mexico during her pregnancy. malaria had not been diagnosed nor was it considered at the time of her delivery at this hospital. review of this and six other cases o ... | 1977 | 329210 |
| [obscure diagnosis of malaria (author's transl)]. | | 1977 | 329379 |
| separation of parasitized erythrocytes from plasmodium berghei infected mouse blood. | | 1977 | 329491 |
| active immunization against the malaria parasite plasmodium berghei in mice: sulfathiazole treatment of a p. berghei infection and development of immunity. | | 1977 | 329500 |
| malaria endemicity among orang asli (malaysian aborigines) as determined by indirect fluorescent antibody tests. | fluorescent antibodies were detected in 89% of 288 orang asli (malaysian aborigines) with plasmodium falciparum antigen and in 62% with p. brasilianum (for p. malariae) antigen. blood films from 18 donors were positive for p. falciparum; 2 of them had mixed infection with p. vivax. seven of the p. falciparum-positive blood films were from children in the 2- to 9-year age group. of 17 sera from cord blood, 16 had significant levels of p. falciparum antibody and 14 of p. malariae antibody, the lev ... | 1977 | 329695 |
| morphologic variants of anopheles albimanus and susceptibility to plasmodium vivax and p. falciparum. | three morphologically different, true-breeding phenotypes have been isolated from a strain of anopheles albimanus from lake apastepeque, el salvador. studies with coindigenous strains of plasmodium vivax and p. falciparum show that these phenotypes differ significantly in their susceptibility to malaria parasites. this difference is apparent both in the number of mosquitoes that become infected and the level of infection obtained. variations in malaria susceptibility are markedly greater with p. ... | 1977 | 329696 |
| malaria along the southernmost fringe of its distribution in africa: epidemiology and control. | after more than thirty years of malaria control in northern transvaal with residual insecticides, malaria prevalence has been reduced to a low level. however, low-grade transmission of plasmodium falciparum continues, with periodic focal outbreaks after abnormally high rainfall. from october 1973 to september 1976, the operational and epidemiological factors involved in this residual transmission were studied in over 17 000 people of an area of northern transvaal. incidence surveys based on the ... | 1977 | 330017 |
| crossreactivity with sporozoites, exoerythrocytic forms and blood schizonts of plasmodium berghei in indirect fluorescent antibody tests with sera of rats immunized with sporozoites or infected blood. | ifa studies are reported using plasmodial antigens from three different stages of the life cycle of plasmodium berghei: sporozoites (sp); exoerythrocytic schizonts in rat liver (eef); and parasitized rat erythrocytes (sch = schizonts). two series of specific sera were applied: sera from adult rats with a blood-induced infection (series a) and sera from rats immunized against sporozoites by mosquito bites and protected against parasitaemia by chloroquine (series b). in series a antibody titres wi ... | 1977 | 330066 |
| plasmodium berghei: suppressed response of antibody-forming cells in infected mice. | | 1977 | 330185 |
| plasmodium berghei: formation of secondary immune complexes in hyperimmune mice. | | 1977 | 330189 |
| plasmodium yoelii and plasmodium vinckei: the effects of nonspecific immunostimulation on murine malaria. | | 1977 | 330190 |
| plasmodium berghei: transmission by intraperitoneal inoculation of immature exoerythrocytic schizonts from rats into rats, mice, and hamsters. | | 1977 | 330191 |
| transmission of mammalian malaria using immature exoerythrocytic schizonts. | | 1977 | 330199 |
| [an entomologic method for the evaluation of the preventive measures used in the campaigns of malaria control]. | | 1977 | 330300 |
| prevention of recrudescent malaria in nude mice by thymic grafting or by treatment with hyperimmune serum. | nude mice died when infected with the normally avirulent malarial parasite plasmodium berghei yoelii. furthermore, malaria recrudesced in nu/nu mice after the termination of acute disease by treatment with clindamycin. recrudescence was not observed in nu/nu mice that had been grafted with thymic tissue or treated with hyperimmune serum. mice mad b cell deficient by treatment with anti-mu-chain serum also died when infected with p. berghei yoelii. the data suggest that a crucial role of the thym ... | 1977 | 330396 |
| the nephrotic syndrome in malawian blacks. | this study deals with the nephrotic syndrome in 34 malawian blacks, plasmodium malariae infection and the use of mercury-containing skin lightening creams (butone 3) must be included among the usual causes of nephrotic syndrome in the malawian black. | 1977 | 331510 |
| host heme catabolism in drug-sensitive and drug-resistant malaria. | chloroquine resistance has arisen in both human and murine forms of malaria. cr plasmodium berghei in mice does not produce the malaria pigment which is characteristic of the cs form. determinations of carbon monoxide production (i.e., host heme catabolism) by individual mice revealed that those infected with cs p. berghei produce only one fourth as much carbon monoxide as do cr infected mice at all levels of infection. these observations confirm the idea that malaria pigment is composed of prec ... | 1977 | 333045 |
| indirect flourescent antibody tests for plasmodium falciparum infections. | | 1977 | 333246 |
| the prevention and treatment of malaria. | | 1977 | 333247 |
| influence of 9-beta-d-arabinofuranosyladenine on total protein synthesis and on differential gene expression of unique proteins in the rodent malarial parasite plasmodium berghei. | the antibiotic 9-beta-d-arabinofuranosyladenine is a drug with a broad spectrum of activity against animal viruses, with little or no effect on mammalian cells, when administered in vivo or in vitro. here we report that the antibiotic markedly inhibited the incorporation of [35s]methionine into malarial protein. inhibition was apparent when the parasites were either exposed to the drug in vivo during the course of infection or incubated with the drug in vitro. moreover, the antibiotic induced pr ... | 1977 | 333437 |
| malaria control in the labour forces of the tan-zam railway. | | 1977 | 333667 |
| active immunization against the malaria parasite plasmodium berghei in mice. the immunizing inoculum. | in the immunization procedure of swiss and c3h/stz mice against p. berghei the inoculum plays an important role. only viable parasites are able to induce immunity when multiple inoculations (10(5) p.e. per mouse) or a single inoculation (1-4 x 10(7) p.e. per mouse) are administered. the inoculated parasitized erythrocytes should enter the vascular system. the subcutaneous route is inappropriate, since subsequent immune reactions are notably absent. in combination with a given suppressive regimen ... | 1977 | 333671 |
| plasmodium berghei: immunization of rats with antigens from a population of free parasites rich in merozoites. | | 1977 | 333672 |
| alterations of human serum proteins and other biochemical parameters after five to ten days of untreated acute falciparum malaria. | untreated malaria for more than 4 days in eleven patients decreased significantly prealbumin, transferrin levels and increased sgot activity when compared with a control group and a group of 10 malaria patients who were admitted to the hospital at an earlier stage of the infection. total protein was significantly lower in the group of patients admitted after five to ten days to hospital compared with the control group. in all malaria patients independent of the duration of the acute infection th ... | 1977 | 333673 |
| transfer of immunity to plasmodium berghei by spleen and lymph node immune rna. | | 1977 | 334380 |
| plasmodium falciparum in culture: use of outdated erthrocytes and description of the candle jar method. | | 1977 | 335035 |
| [present-day problems of malaria. recent acquisitions in immunology]. | | 1977 | 335485 |
| [clinical aspects of malalaria in france]. | | 1977 | 335486 |
| [glomerular renal disease and malaria]. | | 1977 | 335487 |
| intestinal and blood parasites in the north lore district, central sulawesi, indonesia. | over 1,000 stool specimens from residents of the napu and besoa valleys, central sulawesi, indonesia were examined. schistosoma japonicum was detected in 31% of napu valley residents while in only 2% of the besoa valley residents. hookworm infections were the most frequently encountered helminth parasitisms in both valleys. other helminth parasites encountered were: ascaris lumbricoides, trichuris trichiura, enterobius vermicularis, strongyloides stercoralis, physaloptera sp., diphyllobothrium s ... | 1977 | 335530 |
| chloroquine-erythromycin potentiation in p. berghei. | | 1977 | 335993 |
| [tertiary malaria with acute lung edema in a turkish child]. | in the past 10-15 years there has been a continuous increase of imported cases of malaria in the federal republic of germany. the case of a two-year-old child of a turkish foreign worker with severe tertian malaria complicated by pulmonary edema is described. in general tertian malaria is rarely fatal to adults, but in children the primary attack can be life threatening. | 1977 | 336495 |
| protection of mice against malaria by a killed vaccine: differences in effectiveness against p. yoelii and p. berghei. | (c57bi x balb/c)f1 mice are normally killed by a strain of the malaria p. yoelii, but they can be fully protected by a killed vaccine. the best results were obtained with saponin-lysed parasitized cells subsequently fixed with 0-06% formalin and injected intravenously with the adjuvant b. pertussis, though good protection was also obtained without the adjuvant. the protection was specific and at least partly mediated by a serum factor. a similar regime gives little or no protection against p. be ... | 1977 | 336522 |
| efficacy of 5-day radical treatment of p. vivax infection in tamil nadu. | | 1977 | 336529 |
| synthesis and antiprotozoal activity of 2,5-bis(4-guanylphenyl)thiophenes and -pyrroles. | | 1977 | 336890 |
| chloroquine susceptibility in malaria: dependence on exposure of parasites to the drug. | | 1977 | 337017 |
| [fatal course of tropical malaria with consumption coagulopathy]. | | 1977 | 337040 |
| [identification of plasmodial antibodies in the immunodiagnosis of malaria (author's transl)]. | out of 880 sera which were examined for antibodies to plasmodia 69 (7.8%) reacted only with p. falciparum antigen, 371(42.2%) reacted only with p. fieldi antigen, and 440 (50%) responded to both antigens. these groups were differentiated further with antigens from p. vivax, p. ovale, and p. malariae. the results showed that the p. ovale antigen was distinguished by a marked activity with those sera that had reacted only with p. fieldi in the screening test. with sera that had responded to both a ... | 1977 | 337074 |
| effects of foetal haemoglobin on susceptibility of red cells to plasmodium falciparum. | | 1977 | 337159 |
| [falciparum malaria in switzerland: a problem of intensive care?]. | in the period 1972-1976, 5 of 17 patients admitted to the cantonal hospital, basel, for falciparum malaria had to be treated in the intensive care unit. two patients died. none had performed regular chemoprophylaxis and in all of them several days had elapsed between onset of symptoms and diagnosis. the importance of information on malaria to tourists and physicians is stressed. | 1977 | 337475 |