| eosinophil cationic protein and phospholipase a2 activity in human gastric juice. with emphasis on helicobacter pylori status and effects of antacids. | to elucidate possible new effects of antacids, gastric juice from 15 volunteers with known helicobacter pylori status were analysed for eosinophil cationic protein (ecp), phospholipase a2 (pla2) activity, phosphatidylcholine (pc), and bile acids (ba) before and after administration of one tablet of antacid or placebo in a double blind cross-over design. geometric mean ecp concentrations were more than 13 times higher in gastric juice from h. pylori-positive (12.9 micrograms/l) than from h. pylor ... | 1992 | 1475616 |
| omeprazole therapy for helicobacter pylori infection. | to determine whether omeprazole eradicates helicobacter pylori infection of the gastric antrum, six adolescents and one adult with h. pylori colonization of the antrum were entered into a clinical, open trial of medical therapy. histologic evidence of antral gastritis and three complementary methods to document h. pylori colonization of the stomach (silver stain, urease testing, and culture of antrum) were obtained before and after an 8-week course of omeprazole. in vitro susceptibility to omepr ... | 1992 | 1475617 |
| [ulcer epidemiology: old knowledge in a new light]. | low standards of hygiene lead to frequent gastric infection by helicobacter pylori (hp) during early childhood and, subsequently, the development of diffuse atrophic gastric. atrophic gastric in conjunction with environmental factors, such as high dietary salt and low consumption of fruits or vegetables, promote intestinal metaplasia of the gastric mucosa and, possibly, gastric cancer. under improved standards of hygiene, hp is contracted only during adulthood, and gastric atrophy becomes less m ... | 1992 | 1475768 |
| [diagnosis of peptic ulcer disease]. | today the upper gastrointestinal endoscopy is the diagnostic tool of choice to detect peptic gastroduodenal lesions. in case of substantial gastric outlet obstruction or strong suspicion of perforated ulcer, an upper gi-transit with barium or water soluble contrast medium in suspected perforated ulcers may be useful. gastric ulcers are endoscopically controlled up to their complete healing and biopsies taken at each endoscopy in order to rule out gastric cancer. in contrast, duodenal ulcers are ... | 1992 | 1475769 |
| [pathophysiology of ulcer disease]. | the pathogenesis of ulcer disease is complex. the present outline focuses on four main aspects: 1) the mechanisms governing acid production and the role of acid in ulcer disease. 2) the mechanisms regulating mucosal resistance to injury. 3) the association of ulcer disease with antral gastritis and helicobacter pylori infection. 4) ulcer disease and non-steroidal antiinflammatory drugs (nsaids). the complex mechanisms underlying maintenance of mucosal integrity in the normal state and in ulcer d ... | 1992 | 1475770 |
| [prevention of recurrence of ulcer disease: indications and choice of procedure]. | in this contribution we discuss the relapse prophylaxis of ulcers by nonmedicamentous measures, by long-term drug therapy and, in particular, with inhibitors of secretion, by eradication therapy of helicobacter pylori and by surgical therapy. besides secondary prophylaxis (prevention of ulcer relapses), primary prophylaxis (prevention of the first episode) is also briefly treated. | 1992 | 1475772 |
| [future perspectives of ulcer therapy]. | anti-ulcer drugs are amongst the world's most successful pharmaceutical products. whilst the market for histamine h2 antagonists is maturing, that for proton pump inhibitors looks set to expand considerably during the 1990s. indeed, by analogy with anti-hypertensive therapy, enzyme inhibitors could eventually supersede receptor antagonists for the treatment of acid-related diseases. whether a third major cycle of innovative drugs will follow the cimetidine and omeprazole led discoveries of the 1 ... | 1992 | 1475774 |
| antibiotic susceptibility patterns and plasmid profile of helicobacter isolates from nigeria. | antibiotic susceptibility testing and plasmid screening of 50 local isolates of campylobacter coli and campylobacter jejuni were done. all isolates were sensitive to ofloxacin but were resistant to ampicillin, cloxacillin, penicillin, streptomycin and aztreonam. a large number of isolates were sensitive to nalidixic acid (96%), ceftriaxone (96%) and chloramphenicol (86%). it is noteworthy that nine (18%) of the isolates were resistant to each of erythromycin, 15 (30%) were found to harbour plasm ... | 1992 | 1476963 |
| evaluation of new anti-infective drugs for the treatment of gastritis and peptic ulcer disease associated with infection by helicobacter pylori. infectious diseases society of america and the food and drug administration. | helicobacter pylori is a gram-negative, microaerophilic, spiral bacillus. infection by this organism is currently believed to be the major cause of type b gastritis. inflammation and infection may persist for years in the absence of therapeutic intervention. there is currently no approved antimicrobial therapy for gastritis. clinical investigations have shown that combination regimens including bismuth salts and antimicrobial drugs result in the relief of symptoms, the resolution of histologic e ... | 1992 | 1477242 |
| [is detection of helicobacter pylori in a patient with 2/3 gastrectomy 6 years ago for stomach cancer, a risk factor for development of tumor recurrence and is therefore a candidate for pathogen eradication?]. | | 1992 | 1478835 |
| helicobacter pylori, gastritis, and peptic ulceration in the elderly. | to determine the histopathological types of gastritis, presence of h pylori, and of peptic ulceration in patients aged 70 and over, compared with younger adults. | 1992 | 1479032 |
| halitosis and helicobacter pylori. a possible link? | the exact pathophysiological mechanism of halitosis is not clear, and in many patients the etiology is an enigma. we followed three couples in which one member or both had halitosis. all the subjects had evidence of helicobacter pylori infection. all received a treatment course of colloidal bismuth subcitrate four times a day and 250 mg metronidazole three times a day. there was impressive improvement in their symptoms, the halitosis disappearing along with eradication of the organism. we call t ... | 1992 | 1479169 |
| [modified combined omeprazole/amoxicillin therapy for helicobacter pylori eradication: a pilot study]. | patients with h.pylori positive peptic ulcer disease were treated with a two weeks regimen consisting of 20 mg omeprazole twice daily and 500 mg amoxicillin six times daily. subsequently, an h2-receptor antagonist was started (300 mg ranitidine) at night time for four weeks. before and one month after completion of antibiotic therapy an upper gi-tract endoscopy was performed for determination of h.pylori infection [biopsy urease test (but), specific culture and histologic demonstration]. a total ... | 1992 | 1479866 |
| [the laser therapy of patients with a long-term nonhealing stomach ulcer]. | results are presented of treatment of 109 patients with prolonged nonhealing gastric ulcers using a new method of highly intensive impulse laser radiation. a scarring effect was achieved in 87% of cases. correction of immunological indices and sanation of pathological flora, apparently, contributes to the favourable effect. | 1992 | 1481509 |
| chronic erosions of the antral mucosa: a sequela of helicobacter pylori-induced gastritis. | the etiopathogenesis of chronic erosions of the antral mucosa still remains to be clarified. in order to investigate the question as to whether chronic erosions might be a sequela of helicobacter pylori-induced gastritis, we submitted biopsy material obtained from 250 patients with chronic erosions of the antral mucosa to a histological evaluation. the grading of helicobacter pylori colonisation, and gastritis was compared with the results of histological evaluation of the biopsy material obtain ... | 1992 | 1481549 |
| [eradicate helicobacter pylori at any price?]. | | 1992 | 1483613 |
| [prevalence of helicobacter pylori in gastric pathology in aragon]. | the aim of this study was to evaluate the prevalence of helicobacter pylori in 400 patients referred for upper digestive tract endoscopy. in our area it hasn't developed yet any epidemiologic study about this disease. helicobacter pylori was observed in 281 of the 400 patients studied (70%). no significant differences by sex were found in the subjects analyzed. there was a rise in the percentage of positivities as age increased. helicobacter pylori were positive in 74 of the 88 patients with chr ... | 1992 | 1485982 |
| [helicobacter pylori in our country]. | | 1992 | 1485996 |
| review article: urease, gastric ammonium/ammonia, and helicobacter pylori--the past, the present, and recommendations for future research. | the presence of ammonium in gastric contents was described in 1852; urease activity in the stomach was identified 70 years later. the discovery of gastric urease resulted in intense research activity to discover its origin, function, and relation to the gastric levels of ammonium and urea. interest in urease waned in the 1960s as most pertinent questions appeared to have been addressed and there was strong evidence that gastric urease was not a property of the stomach but was of microbial origin ... | 1992 | 1486153 |
| short report: omeprazole plus antibiotic combinations for the eradication of metronidazole-resistant helicobacter pylori. | twenty-eight helicobacter pylori-positive patients with metronidazole-resistant isolates and 25 with metronidazole-sensitive isolates were treated for 14 days with 40 mg omeprazole nocte plus 500 mg amoxycillin t.d.s. eradication of h. pylori, defined as absence of the organism one month after cessation of treatment, was assessed using the [14c]urea breath test. the eradication rate in patients with metronidazole-resistant isolates was 14/28 (50%) while that in patients was metronidazole-sensiti ... | 1992 | 1486161 |
| field evaluation of a rapid, simple and inexpensive urease test for the detection of helicobacter pylori. | a modified rapid urease test (mru test) for the detection of helicobacter pylori was evaluated under field conditions during an endoscopic survey in rural india and compared with a commercially available urease test (clo test) and with histology. of 195 consecutive subjects who underwent upper gastrointestinal endoscopy, 153 (78.5%) were positive for helicobacter pylori when tested by the clo test and/or histology. the sensitivity and specificity of the mru test relative to this was 97.4 and 95. ... | 1992 | 1486185 |
| helicobacter pylori: a risk and severity factor of non-steroidal anti-inflammatory drug induced gastropathy. | this prospective study aimed to determine the prevalence of helicobacter pylori infection in relation to the occurrence and severity of nsaids induced gastropathy. a total of 111 patients were studied-66 were taking nsaids and 45 were control patients. all patients underwent endoscopy during which antral biopsy specimens were taken to determine h pylori status (gram and giemsa staining, urease test, and cultures). the nsaid group comprised: group i, patients without mucosal damage (n = 28); grou ... | 1992 | 1487160 |
| role of ammonia in the pathogenesis of the gastritis, hypergastrinaemia, and hyperpepsinogenaemia i caused by helicobacter pylori infection. | studies were performed in patients with and without renal failure to investigate the role of bacterial ammonia production in the pathogenesis of the mucosal abnormalities caused by helicobacter pylori. the high rate of h pylori ammonia production in uraemic patients should accentuate any ammonia induced effects. the median (range) gastric juice ammonium concentration in the h pylori positive patients with renal failure was 19 mmol/l (ii-43) compared with 5 mmol/l (1-11) in the h pylori positive ... | 1992 | 1487161 |
| serum pepsinogens in blood transfusion donors. | | 1992 | 1487171 |
| identification of formyl met-leu-phe in culture filtrates of helicobacter pylori. | helicobacter pylori synthesizes and secretes a substance which co-chromatographs and is antigenically cross-reactive with the bacterial chemotactic peptide fmet-leu-phe. using reverse phase and affinity chromatography this substance has now been purified. carboxypeptidase y microsequencing has verified that this material is fmet-leu-phe. the infiltration of polymorphonuclear leucocytes to sites of h. pylori infection may be a response to mucosal permeation of soluble, diffusable bioreactive subs ... | 1992 | 1488023 |
| [combined treatment of helicobacter pylori infection--7-day or 14-day treatment?]. | | 1992 | 1488348 |
| helicobacter pylori and gastroduodenal disease. | | 1992 | 1488659 |
| clotest (rapid urease test) in the diagnosis of helicobacter pylori infection. | over a period of 3 months, 85 patients who underwent gastroscopy had antral biopsy taken for clotest, histology and/or culture for helicobacter pylori (hp). the sensitivity and specificity of clotest were found to be 77% and 96% respectively with negative predictive value of 63% and positive predictive value of 98%. ninety-two percent of the positive clotests were positive within 20 minutes, thus giving rapid result. therefore, clotest is a rapid, sensitive and highly specific test for hp infect ... | 1992 | 1488662 |
| evaluation of therapies in the treatment of helicobacter pylori associated non-ulcer dyspepsia. | this randomised double blind placebo controlled study evaluated the effectiveness of colloidal bismuth subcitrate (cbs), ampicillin and their combination in the treatment of helicobacter pylori in non-ulcer dyspepsia (nud) and assessed if elimination of this organism is associated with improvement of gastritis and the symptoms. forty-eight nud patients with h. pylori and histologic gastritis were randomly allocated to one of the three regimens for 28 days. symptoms were assessed before and after ... | 1992 | 1488663 |
| nonsteroidal anti-inflammatory drug gastropathy--is it preventable? | | 1992 | 1489292 |
| 16s rrn gene copy number in helicobacter pylori and its application to molecular typing. | the copy number of the genes encoding 16s ribosomal rna was analysed for the genomes of geographically diverse strains of helicobacter pylori, and restriction site variation within and around the genes was characterized. a dna probe of 550 bp was amplified by the polymerase chain reaction from genomic dna of the type strain nctc 11637. this probe constituted a sequence internal to the 3' end of the 16s rrn gene. homology profiles were compared for genomic southern blots made with four restrictio ... | 1992 | 1490911 |
| [frequency of helicobacter pylori in chronic gastritis with endoscopically defined erosion]. | the frequency of helicobacter pylori was histopathologically evaluated in biopsy specimens of the gastric mucosa from 112 patients which endoscopically diagnosed as erosion. the specimens, histopathologically diagnosed as chronic gastritis, were divided into eight groups according to age, sex and location. the helicobacter pylori infection was revealed in 65% of all specimens observed, and the frequency in patients of their sixties was lower than that of the forties. the frequency in the elder w ... | 1992 | 1491463 |
| [histological studies of the occurrence of organisms shaped like campylobacter in the abomasum of calves]. | the mucosa of the abomasum is a strongly acidic and therefore germ poor, but not entirely germfree environment. only in isolated areas of the fundic glands zone were straight rods in the foveolas, and even more seldom spiral shaped bacteria could be encountered. they had no relation to the inflammatory infiltrates. on the other hand, campylobacter-like organisms were more often observed in the pyloric region and, preferably, in a narrow zone following the cutaneous mucosa of the omasum. these or ... | 1992 | 1492515 |
| helicobacter (aka campylobacter) pylori as the major causal factor in chronic hypochlorhydria. | helicobacter (formerly known as campylobacter) pylori, a recently discovered gastrointestinal bacterial pathogen, has been shown to be etiologic for type b or antral gastritis, and usually has chronic active pathological changes associated with its presence. acute helicobacter infection in most cases induces reduced stomach acid secretion which usually returns to normal levels of secretion after a few months. yet helicobacter gastritis has never been known to spontaneously remit after it has bee ... | 1992 | 1494326 |
| the clinical importance of hypochlorhydria (a consequence of chronic helicobacter infection): its possible etiological role in mineral and amino acid malabsorption, depression, and other syndromes. | in a previous paper evidence was presented to show that helicobacter-induced chronic gastritis is the probable cause of most chronic hypochlorhydria. in this article evidence is presented for the clinical relevance of reduced stomach acid secretion. reduced mineral absorption is fairly well documented and has sound theoretical support from basic chemistry. impaired digestion of protein has been suggested by a few studies. small intestinal bacterial overgrowth in hypochlorhydria probably leads to ... | 1992 | 1494327 |
| [current pathogenetic principles in peptic ulcer]. | new concepts in the pathophysiology of peptic ulcers must acknowledge 1. the close association of ulcers and helicobacter pylori infection, 2. the protective role of endogenous prostaglandins, 3. the scarcity of new data on the importance of acidity (though presence of gastric acid remains indispensible for ulcer development). the different pathophysiologically relevant factors closely interact with each other. however, many not of actual concepts are still experimental and--apart from helicobac ... | 1992 | 1496202 |
| blood ammonia and helicobacter pylori. | | 1992 | 1497562 |
| autoimmune gastritis: is helicobacter pylori a merely commensal or a pathogenic agent? | | 1992 | 1499458 |
| [new aspects in the pathogenesis of gastroduodenal ulcer]. | | 1992 | 1499523 |
| helicobacter pylori, musings from the epidemiologic armchair. | the literature on helicobacter pylori has become enormous, but the epidemiology of the infection remains an enigma. guided by epidemiologic principles we have tried to interpret the available data on the epidemiologic aspects of h. pylori. we conclude that conflicting results on familial clustering and seroprevalence curves might have logical explanations. however, the exact way this organism spreads among humans remains to be solved. | 1992 | 1499674 |
| some german remarks on 'one american response to the sydney system'. | | 1992 | 1499918 |
| grading and classification of chronic gastritis: the response of the working party. | | 1992 | 1499919 |
| helicobacter pylori infection and gastric function in patients with chronic idiopathic dyspepsia. | helicobacter pylori infection, histological features of the gastric mucosa, and gastric motor and secretory functions were evaluated in 45 consecutive patients with chronic idiopathic dyspepsia. h. pylori infection was found in 60% of dyspeptic patients, compared with 33% of 15 healthy controls (p = 0.1). no difference was detected in basal or stimulated gastric acid secretion between dyspeptic patients and healthy controls. gastric emptying was significantly (p less than 0.01) delayed in dyspep ... | 1992 | 1499926 |
| helicobacter pylori in hispanics: comparison with blacks and whites of similar age and socioeconomic class. | helicobacter pylori infection is twice as frequent in blacks as in whites. it has been postulated that the apparent increase in susceptibility to h. pylori infection in blacks might have a genetic basis. a case-control seroepidemiologic study of h. pylori prevalence was performed in 108 healthy hispanic volunteers. eighty-nine hispanics were matched (1:1:1) with blacks and whites for age and socioeconomic status. there was an inverse correlation between h. pylori infection and educational level ... | 1992 | 1499931 |
| selection of the chimpanzee over the baboon as a model for helicobacter pylori infection. | baboons (papio sp.) and chimpanzees (pan troglodytes) were screened for the presence of helicobacter pylori. the gastric mucosae of the baboons were colonized by large spiral bacteria. however, a group of adult chimpanzees were identified that were free of spiral gastric bacteria, with five animals being recruited into an h. pylori challenge study. these animals were inoculated orogastrically with one of four strains of h. pylori and followed for up to 26 weeks. h. pylori was established in one ... | 1992 | 1499934 |
| [isolation of h. pylori proteins and support for their suitability in serologic diagnoses]. | h.pylori-proteins were separated using gel chromatographic methods. these antigens were tested for their suitability to detect h.pylori-specific antibodies. a complex of two proteins (62 kda and 30 kda) was a strong and specific antigen. a third protein (13 kda) was a good but nonspecific antigen. concerning these facts we compared two often used antigen preparations for serodiagnosing h.pylori-specific antibodies (acid-glycine preparation and sarcosyl-insoluble outer membrane proteins). the sar ... | 1992 | 1500074 |
| characteristics of helicobacter pylori variants selected for urease deficiency. | the urease of helicobacter pylori is suspected to play a role in the pathogenesis of gastritis. although all clinical isolates of h. pylori are urease positive (u+), we have selected and characterized several spontaneously arising urease-negative (u-) variants from wild-type strain 60190. urease-negative variants were identified by growth in medium containing 60 mm urea and arose at a frequency of 10(-5) to 10(-6). the urease activity of the wild-type strain inhibited growth of this strain in th ... | 1992 | 1500174 |
| helicobacter pylori-related hypergastrinaemia is not due to elevated antral surface ph. studies with antral alkalinisation. | it has been postulated that helicobacter pylori-related hypergastrinaemia is due to bacterial ammonia raising antral surface ph and thus preventing acid inhibition of gastrin release. if true, the infection should not alter gastrin release at neutral intragastric ph. to test this, we have studied basal and meal-stimulated gastrin at uncontrolled ph and at ph greater than 6 in duodenal ulcer patients before and after eradication of h. pylori. the median integrated gastrin response to the meal alo ... | 1992 | 1502485 |
| erosive prepyloric changes in dyspeptics and non-dyspeptics in a defined population. the sørreisa gastrointestinal disorder study. | in this population-based endoscopic survey we found erosive prepyloric changes (epc) in 38.5% of dyspeptics and 35.1% of non-dyspeptics. epc were observed more frequently in men than in women in both groups. occurrence of helicobacter pylori was not associated with epc. no common gastrointestinal symptoms were found to be associated with epc. endoscopic duodenitis of the duodenal bulb was found more frequently in subjects with epc of the two highest grades than in subjects without epc. only the ... | 1992 | 1502487 |
| double-blind randomized trial of bismuth subsalicylate and clindamycin for treatment of helicobacter pylori infection. | we evaluated clindamycin and bismuth subsalicylate (pepto-bismol) for treatment of helicobacter pylori infection. patients with culture or histology positive for h. pylori were randomized to receive two tablets of bismuth subsalicylate four times daily for 4 weeks or bismuth combined with 2 weeks of 300 mg clindamycin four times daily. clinical symptoms were recorded before and after treatment by means of visual analog scales. patients in both treatment arms showed improvement in clinical scores ... | 1992 | 1502490 |
| [problems associated with mass-screening system for gastric cancer in japan]. | in the mass-screening system for gastric cancer, subjects are primarily examined by contrasted indirect roentgenography and if secondary examination is diagnosed to be necessary, they are examined by contrasted direct roentgenography or gastric fiberscopy. methods for increasing the efficiency of this system from the standpoint of cost-effectiveness were studied, and the basis for decision of whether or not serological examinations such as of serum pepsinogens and serum anti-helicobacter-antibod ... | 1992 | 1504332 |
| helicobacter pylori infection--a common worldwide environmental risk factor for gastric cancer? | | 1992 | 1505491 |
| recurrent abdominal pain of gastro-intestinal origin. | a consecutive series of 71 children (mean age 8.6 years) with recurrent abdominal pain underwent endoscopic oesophageal, gastric and duodenal biopsy in order to determine whether the pain was of gastro-intestinal origin. of these 71 children, 27 (38%) showed oesophagitis, 14 (20%) cardiac gastritis, 29 (41%) body gastritis, 38 (54%) antral gastritis, and 29 (41%) duodenitis. thus, 66 of the 71 children studied had an inflammatory lesion explaining their complaints. one of the patients had a gast ... | 1992 | 1505571 |
| helicobacter pylori in north indian subjects. | | 1992 | 1506055 |
| proposed mechanism for metronidazole resistance in helicobacter pylori. | metronidazole mic values were determined for ten isolates of helicobacter pylori. under microaerobic conditions four were inhibited by less than 0.25 mg/l, two strains required 2.0 mg/l and four strains had mic greater than 32 mg/l. the strains were tested for their susceptibility to metronidazole after varying lengths of anaerobic exposure prior to or during microaerobic incubation. the susceptibility was determined by e-test and traditional agar dilution technique. the level of susceptibility ... | 1992 | 1506325 |
| antibiotics in the treatment of peptic ulcer disease. | | 1992 | 1506343 |
| [differential diagnosis of peptic ulcer]. | although new pathogenetic findings of peptic ulcers have been detected, there still remain some open questions. accurate anamnestic evaluation will find out risk factors as cigarette-smoking, stress and therapy with nonsteroidal antiinflammatory drugs (nsaids), and will be helpful in differential diagnosis. endoscopy is the diagnostic means of choice, and enables to easy helicobacter pylori detection. since some gastric ulcers are actually carcinomas, it is absolutely necessary to obtain multipl ... | 1992 | 1509765 |
| [helicobacter pylori. new apsects in the pathogenesis of peptic ulcer disease]. | antral gastritis and peptic ulcer disease are closely related to gastric helicobacter pylori (hp) infection. hp possesses several pathogenic features which point to a causal role of hp in the development of gastroduodenal lesions. it is now generally accepted that hp causes type b gastritis, while its role in the pathogenesis of peptic ulcers is still unsolved. according to the classical ulcer concept, peptic ulceration is the result of an imbalance between protective mucosal mechanisms and aggr ... | 1992 | 1509766 |
| helicobacter pylori infection in a pediatric population: in vitro susceptibilities to omeprazole and eight antimicrobial agents. | the in vitro activities of omeprazole and eight antimicrobial agents against 18 clinical strains of helicobacter pylori isolated from a pediatric population were determined by an agar dilution method. ampicillin and erythromycin were the most active agents in vitro. all strains were susceptible to azithromycin, ciprofloxacin, doxycycline, metronidazole, and tinidazole. one isolate demonstrated resistance to cefixime (mic, greater than or equal to 4 micrograms/ml). h. pylori was inhibited by the ... | 1992 | 1510406 |
| the genetics, epidemiology, and early detection of gastrointestinal cancers. | current recommendations for screening large populations for colorectal neoplasia have been promulgated by a number of researchers and authorities who generally agree that ongoing screening is justifiable in high-risk groups but not yet in average-risk groups. nonetheless, it is thought to be justifiable to provide screening for average-risk individuals upon request. choice of tools for screening remains under discussion. colonoscopy is generally agreed to be justifiable in those patients with th ... | 1992 | 1511028 |
| ammonia: a possible promotor in helicobacter pylori-related gastric carcinogenesis. | helicobacter pylori (hp) has been shown to possibly be a pathogen of gastric carcinoma. hp has urease activity and produces ammonia in the stomach. in this study, the role of ammonia on gastric carcinogenesis induced by n-methyl-n'-nitro-n-nitrosoguanidine (mnng) were investigated in rats. after 24 weeks pretreatment with mnng (83 mg/l), 0.01% ammonia or tap water as a drinking water was administered for 24 weeks. the ammonia-treated rats showed a significantly higher incidence of gastric cancer ... | 1992 | 1511405 |
| identification of erythrocyte-binding antigens in helicobacter pylori. | the surface antigens of helicobacter pylori conferring erythrocyte-binding activity were obtained by adsorption onto formaldehyde-treated dog and goat erythrocytes from supernatant fractions of sonicated bacteria and elution using a high concentration of nacl. the desorbed material was analysed by sds-page and immunoblotting with anti-whole-cell serum to agar-grown bacteria which had been absorbed with broth-grown, non-haemagglutinating cells (haemagglutination-associated antiserum). two polypep ... | 1992 | 1512579 |
| [detection of campylobacter species by using polymerase chain reaction and nonradioactive labeled dna probe]. | we have detected campylobacter species which are now recognized as major pathogens of acute diarrheal disease in humans using polymerase chain reaction (pcr) and a nonradioactive labeled dna probe. diagnosis of campylobacter enteritis without doing culture from stool samples is of great benefit in the laboratory. two oligonucleotide primers (20 mer) complementary to a unique sequence of the dna encoding ribosomal rna (rrna) of campylobacter jejuni for pcr were synthesized by solid-phase phosphoa ... | 1992 | 1513035 |
| fluoride as a possible aetiological factor in non-ulcer dyspepsia. | a prospective case controlled study was conducted to evaluate the role of fluoride as a possible aetiological factor for non-ulcer dyspepsia (nud). twenty patients with nud and 10 age and sex matched healthy controls were subjected to clinical evaluation, upper gastrointestinal endoscopy and biopsies from the gastric antrum and duodenum. the antral and duodenal mucosa was subjected to a rapid urease test for helicobacter pylori and histological and electron microscopic examinations. fluoride lev ... | 1992 | 1515558 |
| helicobacter pylori serology in patients with coeliac disease and dermatitis herpetiformis. | to investigate whether helicobacter pylori infection or autoimmune gastritis is responsible for the reported increase in gastric pathology and abnormalities of gastric function in patients with coeliac disease and dermatitis herpetiformis (dh). | 1992 | 1517459 |
| helicobacter pylori infection in children: clinical, endoscopic, and histologic correlations. | we have assessed 270 consecutive patients (age range 0.8-20 years) referred for endoscopic study because of abdominal pain during 32 months. helicobacter pylori (hp) was detected by culture in 91 cases (33.7%). hp colonization increased significantly with age (p less than 0.01). nine patients less than 5 years of age were colonized by hp. a previous history of peptic ulcer disease in first-degree relatives was significantly more frequent in the hp-positive group (p less than 0.001). the frequenc ... | 1992 | 1517945 |
| prediction of helicobacter pylori in gastric specimens by inflammatory and morphological histological evaluation. | statistical correlations and predictive values were calculated for 330 gastrointestinal biopsies and tissues, of which 248 were from the stomach from 115 patients in this retrospective study, which graded 10 inflammatory and 14 morphological mucosal and submucosal abnormalities and compared them with the presence of helicobacter pylori. analysis revealed that 78 (31.5%) of the 248 stomach biopsies and tissues showed h. pylori, and 21 (8.5%) had non-helicobacter-like bacteria, such as rods and co ... | 1992 | 1519569 |
| helicobacter pylori. its role in the pathogenesis of peptic ulcer disease in a new animal model. | the association and causative role of helicobacter pylori infection of the stomach with gastric ulcer, duodenal ulcer, non-ulcer dyspepsia, and gastritis has remained controversial. the authors studied the effects of daily intragastric administration of h. pylori suspension in saline (10(8) cfu/ml) and bacteria-free filtrates of saline h. pylori suspensions in 85 sprague-dawley rats (weight, 150 to 200 g) with normal mucosa and with surgically produced experimental gastric ulcers. group i rats ( ... | 1992 | 1519673 |
| management and response to treatment of helicobacter pylori gastritis. | gastritis associated with helicobacter pylori was present in gastric biopsies from 24/95 (25%) children and adolescents undergoing endoscopy for recurrent abdominal pain and upper gastrointestinal symptoms. h pylori associated gastritis occurred mainly in older children (8-16 years) and was significantly associated with low socioeconomic class and a family history of peptic ulcer disease. antral nodularity was a common endoscopic finding in h pylori positive children. eighteen children, all over ... | 1992 | 1519961 |
| igg subclass antibodies against helicobacter pylori heat-stable antigens in normal persons and in dyspeptic patients. | measurement of serum igg antibodies against helicobacter pylori seems to be useful in the diagnosis of h. pylori infections. igg subclass antibodies against h. pylori have, however, not been investigated thoroughly. in this study igg1, igg2, igg3 and igg4 antibody levels against h. pylori were measured using an elisa technique in 187 normal adult persons and in 174 patients with dyspeptic symptoms, of whom 99 patients were h. pylori positive. none of the igg subclass antibody levels were better ... | 1992 | 1520486 |
| helicobacter pylori: its role in disease. | | 1992 | 1520782 |
| therapeutic approaches to recurrent peptic ulcer disease. | | 1992 | 1522168 |
| serum neutralizing antibody response to the vacuolating cytotoxin of helicobacter pylori. | approximately 50% of helicobacter pylori isolates produce a cytotoxin in vitro that induces vacuolation of eukaryotic cells. to determine the in vivo relevance of this phenomenon, we sought to detect cytotoxin-neutralizing antibodies in sera from h. pylori-infected persons. as a group, sera from 29 h. pylori-infected patients neutralized the activity of the purified cytotoxin to a significantly greater extent than sera from 24 uninfected persons (p = 0.007). the cytotoxin neutralizing activity i ... | 1992 | 1522241 |
| vaccine errors. | | 1992 | 1522916 |
| [the role of the polyclinic in raising the efficacy of rehabilitation with peptic ulcer patients]. | the authors provide the results of the treatment and prophylaxis of peptic ulcer (pu) patients followed up by the polyclinic for 14 years. on a large factual material they estimate the efficacy of pu patients treatment with the use of drugs belonging to different groups, including drugs that exert antisecretory, cytoprotective and antibacterial effects. during the follow-up period, the number of patients with medium-grave and grave pu decreased whereas that of patients with mild disease and no r ... | 1992 | 1523569 |
| helicobacter pylori and atrophic gastritis. | sixty-four consecutive patients which on upper gastrointestinal endoscopy had endoscopic signs of atrophic body gastritis were investigated with standard histology examinations of gastric biopsies, serology and/or culture for helicobacter pylori and with standard blood chemistry profile. a histologic diagnosis of atrophy could be made in only 27 of the 64 patients (42%). of these 27 patients, 5 had the pernicious anaemia (pa) type (19%), 22 had not (81%). past and/or present h. pylori infection ... | 1992 | 1523687 |
| helicobacter pylori. new diagnostic tools. clinical and experimental studies on local and systemic immune response. minireview based on a doctoral thesis. | | 1992 | 1523731 |
| catalase negative mutants of helicobacter pylori. | nine strains of helicobacter pylori have been isolated exhibiting spontaneous mutations with a loss of catalase activity. growth characteristics in vitro were unaffected by the mutation showing that catalase is not essential for growth of helicobacter pylori. parent strains and mutants could not be distinguished morphologically from each other when compared by electron microscopy. restriction endonuclease digestion with hindiii, separated in an 0.7% agarose gel in tbe buffer, showed each pair to ... | 1992 | 1526235 |
| gastric emptying, esophageal 24-hour ph and gastric potential difference measurements in non-ulcer dyspepsia. | pathological gastroesophageal reflux, prolonged gastric emptying and abnormal gastric potential difference have been claimed to be functional disorders often detectable in non-ulcer dyspspsia (nud). the role of helicobacter pylori in nud is still unclear. the aim of the present study was to evaluate the prevalence of these factors in 47 patients with nud. according to demeester's criteria, 60 percent of nud patients had abnormal gastroesophageal reflux, while 38 percent had prolonged gastric emp ... | 1992 | 1526393 |
| [epidemiologic characteristics of helicobacter pylori infections]. | | 1992 | 1528151 |
| duodenal ulcer and eradication of helicobacter pylori in a developing country. an 18-month follow-up study. | forty-eight patients with endoscopically proven duodenal ulcer (du) and helicobacter pylori infection detected by 14c-urea breath test (bt) were assigned to 5 days of treatment with furazolidone, metronidazole, and amoxicillin in addition to eventual classical anti-ulcer agents if necessary. clinical evaluation and bt were repeated at 2, 6, and 18 months after therapy to determine h. pylori eradication or reinfection. endoscopy was also repeated at 6 and 18 months after treatment to detect du re ... | 1992 | 1529269 |
| frequency of helicobacter pylori and gastritis in healthy subjects without gastrointestinal symptoms. | to investigate the frequency of helicobacter pylori and gastritis in asymptomatic adults, 30 healthy volunteers underwent upper endoscopy. biopsy specimens were obtained from the corporeal and antral mucosa of the stomach. the specimens were examined by light microscopy for gastritis and the occurrence of h. pylori. in 12 subjects signs of gastritis were noted at endoscopy, but only in 7 of them was this diagnosis confirmed histologically. no other abnormalities were observed by the endoscopist. ... | 1992 | 1529273 |
| longitudinal study of influence of helicobacter pylori on current risk of duodenal ulcer relapse. the hvidovre ulcer project group. | seventy-four patients with duodenal ulcer were followed up longitudinally for 2 years after initial ulcer healing. endoscopy including biopsy of the antral mucosa was performed every 3rd month and whenever clinical symptoms of relapse occurred. the presence of helicobacter pylori in the biopsy specimens was scored as 0 (none), 1 (sporadic occurrence), 2 (clusters), and 3 (numerous bacteria found diffusely in the mucus layer). the incidence rates of ulcer relapse per patient-month, grouped in acc ... | 1992 | 1529279 |
| immunocytochemical identification of rochalimaea henselae in bacillary (epithelioid) angiomatosis, parenchymal bacillary peliosis, and persistent fever with bacteremia. | we report the immunocytochemical identification of rochalimaea henselae, a newly recognized fastidious, gram-negative, warthin-starry-positive organism, as the common pathogen in bacillary angiomatosis (ba), bacillary peliosis (bp) of the liver and spleen, and persistent fever with bacteremia in immunocompromised patients. immunogenic proteins of the r. henselae strain isolated from the blood of a febrile immunocompromised patient with bp of the liver were used to produce primary immune serum in ... | 1992 | 1530106 |
| helicobacter pylori and hypergastrinaemia during proton pump inhibitor therapy. | the rise in serum gastrin and pepsinogen i after 5 days' treatment with the proton pump inhibitor pantoprazole (40 mg/day) was examined in eight duodenal ulcer patients with helicobacter pylori infection and compared with eight in whom it had been eradicated. before treatment, the post-prandial serum gastrin concentrations were higher in the h. pylori-positive than -eradicated patients (p less than 0.05). the median rise in pre-prandial serum gastrin concentrations on treatment was similar in th ... | 1992 | 1532864 |
| antral gastritis, helicobacter pylori, and gastric mucosal sensitivity. | | 1992 | 1537506 |
| relationship of helicobacter pylori to serum pepsinogens in an asymptomatic japanese population. | a seroepidemiologic study of the prevalence of helicobacter pylori infection in japan was performed, and the relationship between serum pepsinogen i and ii levels (markers of gastritis and gastric atrophy) and h. pylori infection was investigated. four hundred and eighteen asymptomatic children and adults were studied. the prevalence of anti-h. pylori immunoglobulin g antibody increased with age. for persons born after 1950, the frequency of h. pylori infection increased at approximately 1% per ... | 1992 | 1537513 |
| the role of helicobacter pylori in recurrent, functional abdominal pain in children. | recurrent abdominal pain in children usually is considered to be functional in nature. we hypothesized that helicobacter pylori infection might be the etiology of abdominal pain symptoms in some children with presumed functional abdominal pain. therefore, we studied 20 children with a previous diagnosis of functional abdominal pain, using a 13c-urea breath test and an enzyme-linked immunosorbent assay for antibody to the h. pylori high molecular weight, cell-associated antigens. two children had ... | 1992 | 1539570 |
| acute helicobacter pylori infection in an infant, associated with gastric ulceration and serological evidence of intra-familial transmission. | reports of the clinical picture and laboratory findings associated with naturally acquired acute h. pylori infection are rare and, although family studies have suggested person-to-person transmission, there have been no accounts of serologically proven intra-familial spread. this report describes the clinical and histological features associated with acute h. pylori infection in an infant and includes serological evidence for the possible transmission of this organism within his direct family. t ... | 1992 | 1539579 |
| chemical gastritis and helicobacter pylori related gastritis in patients receiving non-steroidal anti-inflammatory drugs: comparison and correlation with peptic ulceration. | to evaluate the prevalence and significance of chemical gastritis, in comparison with gastritis related to helicobacter pylori in patients receiving non-steroidal anti inflammatory drugs (nsaids). | 1992 | 1541693 |
| short report: short-term triple therapy for h. pylori-associated duodenal ulcer disease. | thirty consecutive patients with endoscopically proven duodenal ulceration who had helicobacter pylori infection on culture and histology, were treated with tripotassium dicitrato bismuthate (1 tablet q.d.s., 400 mg metronidazole t.d.s. and 500 mg tetracycline t.d.s. for one week, followed by the bismuth salt for a further 3 weeks. all patients were endoscoped at entry and 4 weeks after cessation of treatment, to check for ulcer healing and h. pylori eradication. two antral biopsies were taken a ... | 1992 | 1543813 |
| helicobacter pylori clearance in the treatment of non-ulcer dyspepsia. | one hundred and thirty north nigerian patients with non-ulcer dyspepsia were treated with tripotassium dicitrato bismuthate and amoxycillin, or antacid. symptoms resolved in 28 (33%) of bismuth and amoxycillin recipients completing the trial compared with 1 (4%) of the antacid recipients. symptomatic improvement did not relate to clearance of helicobacter pylori. | 1992 | 1543814 |
| comparison of one-day oral dosing with three bismuth compounds for the suppression of helicobacter pylori assessed by the 13c-urea breath test. | assessment of intragastric urease activity by the 13c-urea breath test was performed before and after one day of dosing with either de-noltabs (tripotassium dicitrato bismuthate, one tablet 1 q.d.s.), pepto-bismol liquid (bismuth salicylate 30 ml q.d.s.), or roter tablets (bismuth subnitrate, one tablet q.d.s.) in twelve helicobacter pylori-positive patient volunteers. there was a significant decrease in the excess of 13co2 after one day of dosing with each of the three bismuth compounds, but an ... | 1992 | 1543820 |
| factors influencing gastroduodenal mucosal prostaglandin concentrations: roles of smoking and aging. | to evaluate behavioral, demographic, clinical, and histologic variables that independently influence gastroduodenal mucosal prostaglandin concentrations. | 1992 | 1546863 |
| biochemical studies of helicobacter mustelae fatty acid composition and flagella. | the fatty acid compositions of helicobacter mustelae whole cells, isolated phospholipids, and isolated lipopolysaccharides were analyzed by gas-liquid chromatography. major phospholipid fatty acids were c16:0, c18:0, c18:1, and c19:0 cyc. in isolated lipopolysaccharides, 3-oh-c16:0, 3-oh-c14:0, c14:0, c16:0, and c18:0 were found. the lipid composition of h. mustelae thus showed pronounced differences from that of h. pylori. flagella were purified by mechanical shearing and centrifugation steps. ... | 1992 | 1548093 |
| low biological activity of helicobacter pylori lipopolysaccharide. | lipopolysaccharide from the gastroduodenal pathogen helicobacter pylori was tested for its ability to induce mitogenicity in mouse spleen cells, pyrogenicity in rabbits, and toxic lethality in galactosamine-sensitized mice. compared with those for enterobacterial lipopolysaccharide, mitogenicity and pyrogenicity were a thousand-fold lower and lethal toxicity was 500-fold lower. we suggest that the phosphorylation pattern and acylation in lipid a are responsible for the low biological activity. | 1992 | 1548097 |
| noninvasive detection of helicobacter pylori colonization in stomach using [11c]urea. | helicobacter pylori is associated with chronic type b gastritis. diagnosis can be made on gastric biopsy specimens and noninvasively using [13c]- or [14c]urea breath tests. both breath tests require meticulous breath collection, and false positive results are possible from urease producing oral-pharyngeal flora. we used [11c]urea, a positron-emitting radionuclide allowing dynamic imaging, to measure metabolism of urea in the stomach of biopsy documented h. pylori-positive patients. [11c]urea was ... | 1992 | 1551356 |
| regulation of gastric acid secretion by gastrin in duodenal ulcer patients and healthy subjects. | to examine the role of gastrin as a major mediator of meal-stimulated acid secretion at low and high intragastric ph, gastric acid secretory responses after exogenous and endogenous stimulation were studied in relation to circulating plasma gastrin levels in 19 healthy control subjects and in 18 patients with inactive duodenal ulcer disease. gastrin was given intravenously in stepwise fourfold-increasing doses from 3.1 to 800 pmol.kg-1.h-1 over consecutive 30-minute periods. circulating plasma g ... | 1992 | 1551523 |
| assessment of enzyme detection tests useful in identification of campylobacteria. | twenty-one type or other reference strains, each representing a different campylobacter, helicobacter, or arcobacter taxon, and a reference strain of staphylococcus aureus were used to assess the reproducibility of nine enzyme detection tests used in the identification of campylobacters. for five of the tests (alkaline phosphatase, dnase, and h2s production, indoxyl acetate hydrolysis, and nitrate reduction), more than one procedure was employed to determine the most suitable method. alkaline ph ... | 1992 | 1551996 |
| [endogenous prostaglandin synthesis and gastritis: lack of correlation with endoscopic findings, helicobacter colonization and leukocytic infiltration of the mucosa]. | we determined the capacity and the profile of prostaglandin synthesis in the antral mucosa of patients with erosive (n = 43) or non-erosive (n = 24) type b gastritis in comparison with normal controls (n = 24). prostaglandin synthesis was measured by the incorporation of 14c-labelled arachidonic acid into cyclooxygenase products in mucosal homogenate. there was no significant difference between controls and patients with antral gastritis. furthermore, there was no correlation of the prostaglandi ... | 1992 | 1553827 |