| inflammatory responses regulating alveolar ion transport during pulmonary infections. | the respiratory epithelium is lined by a tightly balanced fluid layer that allows normal o2 and co2 exchange and maintains surface tension and host defense. to maintain alveolar fluid homeostasis, both the integrity of the alveolar-capillary barrier and the expression of epithelial ion channels and pumps are necessary to establish a vectorial ion gradient. however, during pulmonary infection, auto- and/or paracrine-acting mediators induce pathophysiological changes of the alveolar-capillary barr ... | 2017 | 28458673 |
| sensitivity to antibiotics of bacteria exposed to gamma radiation emitted from hot soils of the high background radiation areas of ramsar, northern iran. | over the past several years our laboratories have investigated different aspects of the challenging issue of the alterations in bacterial susceptibility to antibiotics induced by physical stresses. | 2017 | 28432369 |
| seven new lignan glycosides from the branches of alangium kurzii craib var. laxifolium. | seven new lignan glycosides (1-3, 8-10, and 14) and 17 known compounds were isolated from the branches of alangium kurzii craib var. laxifolium. their structures were established by spectroscopic analysis and circular dichroism (cd) and x-ray analysis. the isolated compounds were evaluated for their antibacterial activities against staphylococcus aureus ci1011, streptococcus suis ci1608, salmonella gallinarum ci0912, enterococcus faecalis ci1304, aeromonas hydrophila ci1008, escherichia coli ci1 ... | 2017 | 28733150 |
| antibacterial effects of lactobacillus isolates of curd and human milk origin against food-borne and human pathogens. | this study was undertaken to assess the antibacterial efficacy of lactobacilli isolated from curd and human milk samples. identities of thirty-one different lactobacilli (20 from curd and 11 from human milk) were confirmed by genus-specific pcr and 16s rrna-based sequencing. these strains belonged to five species, lactobacillus casei, l. delbrueckii, l. fermentum, l. plantarum, and l. pentosus. antibacterial activities of cell-free supernatants (cfss) of all the lactobacillus isolates were estim ... | 2017 | 28401466 |
| preparation, characterization and antibacterial activity of chitosan and phosphorylated chitosan from cuttlebone of sepia kobiensis (hoyle, 1885). | chitosan is a commercially available derivative of chitin that has been extensively studied for its antimicrobial properties. in order to improve the water solubility and its biological activity, the chemical modification or derivatisation is attempted. in the present investigation, the chitosan prepared from the cuttlebone of sepia kobiensis was being chemically modified by reacting it with orthophosphoric acid so as to obtain phosphorylated chitosan. then the chitosan and phosphorylated chitos ... | 2016 | 28507912 |
| bacteriology of peritonsillar abscess: the changing trend and predisposing factors. | peritonsillar abscess (pta) is the most common deep neck infection. the infectious microorganism may be different according to clinical factors. | 2017 | 28756939 |
| bacterial and histopathological findings in deep head and neck infections: a retrospective analysis. | deep neck infections are among the most dangerous acute diseases in the head and neck region. this analysis gives an overview of the bacterial and histopathologic findings of deep neck infections. | 2017 | 28411005 |
| isolation, purification, and characterization of five active diketopiperazine derivatives from endophytic streptomyces suk 25 with antimicrobial and cytotoxic activities. | in our search for new sources of bioactive secondary metabolites from streptomyces sp., the ethyl acetate extracts from endophytic streptomyces suk 25 afforded five active diketopiperazine (dkp) compounds. the aim of this study was to characterize the bioactive compounds isolated from endophytic streptomyces suk 25 and evaluate their bioactivity against multiple drug resistance (mdr) bacteria such as enterococcus raffinosus, staphylococcus aureus, klebsiella pneumoniae, acinetobacter baumanii, p ... | 2017 | 28535606 |
| bioactive molecule from streptomyces sp. mitigates mdr klebsiella pneumoniae in zebrafish infection model. | the emergence and spread of multi-drug resistant (mdr) especially carbapenem-resistant klebsiella pneumoniae is a major emerging threat to public health, leading to excess in mortality rate as high as 50-86%. mdr k. pneumoniae manifests all broad mechanisms of drug resistance, hence development of new drugs to treat mdr k. pneumoniae infection has become a more relevant question in the scientific community. in the present study a potential streptomyces sp. ask2 was isolated from rhizosphere soil ... | 2017 | 28446900 |
| first case report of non-human primates (alouatta clamitans) with the hypervirulent klebsiella pneumoniae serotype k1 strain st 23: a possible emerging wildlife pathogen. | hypervirulent strain of klebsiella pneumoniae genotype k1 isolates have recently emerged, causing severe pyogenic liver abscess complicated by devastating metastatic infections in humans. | 2017 | 28809435 |
| septicemic invasive klebsiella pneumoniae infection in a cynomolgus monkey (macaca fascicularis) with severe diffused suppurative meningoencephalitis. | a 2-year-old male cynomolgus monkey (macaca fascicularis) showed neurological symptoms during quarantine for importation into japan, and was euthanized due to poor prognosis. gross anatomical examination revealed a hemorrhagic lesion around the lateral ventricle in the cerebrum. histologically, severe diffused suppurative meningitis and ventriculitis were detected with numerous gram-negative bacilli in the cerebrum. immunohistochemically, the bacilli were positively stained with an antibody agai ... | 2017 | 28529273 |
| occurrence of carbapenemase-producing enterobacteriaceae isolates in the wildlife: first report of oxa-48 in wild boars in algeria. | the aim of the present study was to screen for the presence of carbapenemase-producing enterobacteriaceae (cpe) isolates from wild boars and barbary macaques in algeria. fecal samples were collected from wild boars (n = 168) and barbary macaques (n = 212), in bejaia, algeria, between september 2014 and april 2016. the isolates were identified and antimicrobial susceptibility was determined. carbapenem resistance determinants were studied using pcr and sequencing, while clonal relatedness was per ... | 2017 | 28799835 |
| genomic epidemiology of ndm-1-encoding plasmids in latin american clinical isolates reveals insights into the evolution of multidrug resistance. | bacteria that produce the broad-spectrum carbapenem antibiotic new delhi metallo-β-lactamase (ndm) place a burden on health care systems worldwide, due to the limited treatment options for infections caused by them and the rapid global spread of this antibiotic resistance mechanism. although it is believed that the associated resistance gene blandm-1 originated in acinetobacter spp., the role of enterobacteriaceae in its dissemination remains unclear. in this study, we used whole genome sequenci ... | 2017 | 28854628 |
| comparison of a new matrix-assisted laser desorption/ionization time-of-flight mass spectrometry platform, asta microidsys, with bruker biotyper for species identification. | matrix-assisted laser desorption/ionization time-of-flight mass spectrometry, with its accuracy and speed, is widely used for bacterial identification. the asta microidsys system (asta, korea) was recently developed for species identification. we compared its performance with that of bruker biotyper (bruker daltonics, germany). microbes were recovered from sputum, urine, and pus samples from patients admitted to a tertiary care hospital in korea from january to april 2016. matrix solution (α-cya ... | 2017 | 28840993 |
| membrane-active macromolecules kill antibiotic-tolerant bacteria and potentiate antibiotics towards gram-negative bacteria. | chronic bacterial biofilms place a massive burden on healthcare due to the presence of antibiotic-tolerant dormant bacteria. some of the conventional antibiotics such as erythromycin, vancomycin, linezolid, rifampicin etc. are inherently ineffective against gram-negative bacteria, particularly in their biofilms. here, we report membrane-active macromolecules that kill slow dividing stationary-phase and antibiotic tolerant cells of gram-negative bacteria. more importantly, these molecules potenti ... | 2017 | 28837596 |
| application of maldi-tof ms fingerprinting as a quick tool for identification and clustering of foodborne pathogens isolated from food products. | foodborne pathogens can be associated with a wide variety of food products and it is very important to identify them to supply safe food and prevent foodborne infections. since traditional techniques are time-consuming and laborious, this study was designed for rapid identification and clustering of foodborne pathogens isolated from various restaurants in al-qassim region, kingdom of saudi arabia (ksa) using matrix-assisted laser desorption ionization-time of flight mass spectrometry (maldi-tof ... | 2017 | 28825446 |
| antimicrobial activity of octenidine against multidrug-resistant gram-negative pathogens. | multidrug-resistant (mr) gram-negative (gn) pathogens pose a major and growing threat for healthcare systems, as therapy of infections is often limited due to the lack of available systemic antibiotics. well-tolerated antiseptics, such as octenidine dihydrochloride (oct), may be a very useful tool in infection control to reduce the dissemination of mrgn. this study aimed to investigate the bactericidal activity of oct against international epidemic clones of mrgn. a set of five different species ... | 2017 | 28825186 |
| [distribution and drug resistance of pathogens at hematology department of jiangsu province from 2014 to 2015: results from a multicenter, retrospective study]. | objective: to describe the distribution and drug resistance of pathogens at hematology department of jiangsu province from 2014 to 2015 to provide reference for empirical anti-infection treatment. methods: pathogens were from hematology department of 26 tertiary hospitals in jiangsu province from 2014 to 2015. antimicrobial susceptibility testing was carried out according to a unified protocol using kirby-bauer method or agar dilution method. collection of drug susceptibility results and corresp ... | 2017 | 28810329 |
| device-associated healthcare-associated infections (da-hai) and the caveat of multiresistance in a multidisciplinary intensive care unit. | device-associated healthcare-associated infections (da-hai), including ventilator-associated pneumonia (vap), central-line-associated blood stream infection (clabsi), and catheter-related urinary tract infection (cauti), are considered as principal contributors to healthcare hazard and threat to patient safety as they can cause prolonged hospital stay, sepsis, and mortality in the icu. the study intends to characterize da-hai in a tertiary care multidisciplinary icu of a teaching hospital in eas ... | 2017 | 28790779 |
| antimicrobial activities of widely consumed herbal teas, alone or in combination with antibiotics: an in vitro study. | because of increasing antibiotic resistance, herbal teas are the most popular natural alternatives for the treatment of infectious diseases, and are currently gaining more importance. we examined the antimicrobial activities of 31 herbal teas both alone and in combination with antibiotics or antifungals against some standard and clinical isolates of pseudomonas aeruginosa, acinetobacter baumannii, escherichia coli, klebsiella pneumoniae, enterococcus faecalis, methicillin susceptible/resistant s ... | 2017 | 28761777 |
| cluster-distinguishing genotypic and phenotypic diversity of carbapenem-resistant gram-negative bacteria in solid-organ transplantation patients: a comparative study. | solid-organ transplant recipients may display high rates of colonization and/or infection by multidrug-resistant bacteria. we analysed and compared the phenotypic and genotypic diversity of carbapenem-resistant (cr) strains of klebsiella pneumoniae, pseudomonas aeruginosa and acinetobacter baumannii isolated from patients in the solid organ transplantation department of our hospital. | 2017 | 28758635 |
| risk factors and predictors of carbapenem-resistant pseudomonas aeruginosa and acinetobacter baumannii mortality in critically ill bacteraemic patients over a 6-year period (2010-15): antibiotics do matter. | acinetobacter baumannii and pseudomonas aeruginosa provoke serious infections, especially in intensive care unit (icu) patients. | 2017 | 28758623 |
| polymyxins for cns infections: pharmacology and neurotoxicity. | central nervous system (cns) infections caused by multi-drug resistant (mdr) gram-negative bacteria present a major health and economic burden worldwide. due to the nearly empty antibiotic discovery pipeline, polymyxins (i.e. polymyxin b and colistin) are used as the last-line therapy against gram-negative 'superbugs' when all other treatment modalities have failed. the treatment of cns infections due to multi-drug resistant gram-negative bacteria is problematic and associated with high mortalit ... | 2017 | 28750947 |
| occurrence of the mcr-1 colistin resistance gene and other clinically relevant antibiotic resistance genes in microbial populations at different municipal wastewater treatment plants in germany. | seven wastewater treatment plants (wwtps) with different population equivalents and catchment areas were screened for the prevalence of the colistin resistance gene mcr-1 mediating resistance against last resort antibiotic polymyxin e. the abundance of the plasmid-associated mcr-1 gene in total microbial populations during water treatment processes was quantitatively analyzed by qpcr analyses. the presence of the colistin resistance gene was documented for all of the influent wastewater samples ... | 2017 | 28744270 |
| antimicrobial efficacy and synergy of metal ions against enterococcus faecium, klebsiella pneumoniae and acinetobacter baumannii in planktonic and biofilm phenotypes. | the effects of metal ion solutions (silver, copper, platinum, gold and palladium) were determined individually and in combination against enterococcus faecium, acinetobacter baumannii and klebsiella pneumoniae. platinum, gold and palladium showed the greatest antimicrobial efficacy in zone of inhibition (zoi) assays. when tested in combinations using zoi assays, gold/platinum, gold/palladium and platinum/palladium were indicative of synergy. microbial inhibitory concentration demonstrated platin ... | 2017 | 28724953 |
| bad bacteria in acute appendicitis: rare but relevant. | bacterial infections are a factor for morbidity in patients with acute appendicitis (aa). the spreading of multidrug-resistant (mdr) bacteria is a significant problem in surgery, and the most relevant mdr pathogens are summarized as enterobacteriaceae, staphylococcus aureus, klebsiella pneumoniae, acinetobacter baumannii, pseudomonas aeruginosa, and enterococci (eskape) bacteria. data regarding the species and distribution of bacteria in aa are available, but information about the resistances an ... | 2017 | 28710611 |
| development of silver nanoparticles loaded chitosan-alginate constructs with biomedical potentialities. | herein, a facile biosynthesis of silver nanoparticles (agnps) and agnps-loaded chitosan-alginate constructs with biomedical potentialities is reported. the uv-vis spectroscopic profile confirmed the synthesis of agnps using methanolic leaves extract of euphorbia helioscopia. the newly developed agnps were characterized using various analytical and imaging techniques including uv-vis and ft-ir spectroscopy, x-ray diffraction (xrd), scanning electron microscopy (sem), energy dispersive spectroscop ... | 2017 | 28705499 |
| antimicrobial susceptibility among gram-positive and gram-negative organisms collected from the latin american region between 2004 and 2015 as part of the tigecycline evaluation and surveillance trial. | the in vitro activity of tigecycline and comparator agents was evaluated against gram-positive and gram-negative isolates collected in latin american centers between 2004 and 2015 as part of the tigecycline evaluation and surveillance trial (t.e.s.t.) global surveillance study. | 2017 | 28701170 |
| investigation and analysis of the characteristics and drug sensitivity of bacteria in skin ulcer infections. | skin ulcer is a common type of disease affecting patients' health and quality of life, and bacterial infection increases the difficulty of its management. | 2017 | 28689800 |
| the respiratory threat posed by multidrug resistant gram-negative bacteria. | respiratory infections are a major cause of global mortality and morbidity. in recent years, an increased incidence of multidrug-resistant (mdr) gram-negative bacteria (gnb) has been described. microorganisms such as pseudomonas aeruginosa, escherichia coli, klebsiella pneumoniae or acinetobacter baumannii have been identified as causative pathogens of different respiratory tract infections. several studies have detected mdr-gnb in patients with community-acquired and nosocomial pneumonia. furth ... | 2017 | 28681941 |
| titanium surfaces immobilized with the major antimicrobial fragment fk-16 of human cathelicidin ll-37 are potent against multiple antibiotic-resistant bacteria. | infections on implanted medical devices are a challenging problem, especially when bacteria form difficult-to-treat biofilms. antimicrobial peptides are considered to be a solution due to their potency against antibiotic-resistant superbugs. previously, the authors' laboratory demonstrated the prevention of staphylococcal biofilm formation in an animal catheter model by injecting merecidin (formerly known as 17biphe2), a peptide engineered based on the only human cathelicidin. this study documen ... | 2017 | 28675109 |
| current problematic and emergence of carbapenemase-producing bacteria: a brief report from a libyan hospital. | a collection of 94 gram-negative bacteria isolates, showing different antimicrobial resistance phenotypes including to the carbapenem classes was investigated. strains were originated form clinical sources from a single hospital in tripoli, libya during 2015 and were identified based on cultural and phenotypic characteristics, and fully characterized by the vitek automated system. forty-eight percent (48%) of the collection was identified as acinetobacter baumannii, 50% klebsiella pneumoniae and ... | 2017 | 28674573 |
| the distribution of carbapenem- and colistin-resistance in gram-negative bacteria from the tamil nadu region in india. | the occurrence of carbapenem- and colistin-resistance among gram-negative bacteria is increasing worldwide. the aim of this study was to understand the distribution of carbapenem- and colistin-resistance in two areas in tamil nadu, india. | 2017 | 28671537 |
| targeted surveillance and infection-related risk factors of nosocomial infection in patients after neurosurgical operation. | the purpose of this study was to investigate the risk factors of nosocomial infection in patients after neurosurgical operations, so as to provide reasonable, effective preventative measures in the future. a total of 1,600 patients with brain tumors, hydrocephalus, craniocerebral trauma and vascular disease treated in the neurosurgery room were chosen for targeted surveillance; and through analysis on the clinical data of patients, the incidence of nosocomial infection, the site of infection and ... | 2017 | 28671080 |
| extended-spectrum beta-lactamase producing gram negative bacteria in iran: a review. | the emergence and spread of extended spectrum β-lactamase (esbl)-producing gram- negative bacteria (gnb), particularly in enterobacteriaceae, acinetobacter baumannii, and pseudomonas aeruginosa, have increased all over the world. esbls are characterized by their ability to hydrolyze β-lactams, early cephalosporins, oxyimino-thiazolyl cephalosporins, and monobactams, but not cephamycins or carbapenems. the rate of nosocomial infections caused by esbl-producing gnb in asia pacific has increased an ... | 2017 | 28670639 |
| inhaled colistin monotherapy for respiratory tract infections in adults without cystic fibrosis: a systematic review and meta-analysis. | inhaled colistin is becoming increasingly popular against respiratory tract infections due to multidrug resistant (mdr) gram-negative bacteria since it may overcome the problems associated with iv administration. | 2017 | 28669836 |
| does acinetobacter baumannii serve as a source for blandm dissemination into enterobacteriaceae in hospitalized patients? | the goal was to study the possibility that acinetobacter baumannii serve as an epidemiologically significant source for transmission of the blandm gene to enterobacteriaceae by horizontal gene transfer (hgt) in hospitalized patients. the study was done at the tel-aviv sourasky medical center from december 2014 until august 2015. clinical and surveillance rectal cultures were collected as per hospital policies and were analyzed for the presence of new delhi metallo-beta-lactamase-producing entero ... | 2017 | 28665176 |
| nonribosomal peptide synthetase biosynthetic clusters of eskape pathogens. | covering: up to 2017.natural products are important secondary metabolites produced by bacterial and fungal species that play important roles in cellular growth and signaling, nutrient acquisition, intra- and interspecies communication, and virulence. a subset of natural products is produced by nonribosomal peptide synthetases (nrpss), a family of large, modular enzymes that function in an assembly line fashion. because of the pharmaceutical activity of many nrps products, much effort has gone in ... | 2017 | 28642945 |
| epidemiology and outcomes of bloodstream infections in 177 severe burn patients from an industrial disaster: a multicentre retrospective study. | to determine the characteristics of bloodstream infections (bsis) and to evaluate the impact of bsis on mortality in severe burn patients. | 2017 | 28642142 |
| clinical characteristics and epidemiology of sepsis in the neonatal intensive care unit in the era of multi-drug resistant organisms: a retrospective review. | sepsis in the neonatal intensive care unit (nicu) remains one of the most significant causes of morbidity and mortality, especially for preterm newborns. multi-drug resistant organisms (mdros) are emerging as important pathogens that cause neonatal sepsis in nicu. therefore, studying the epidemiology, clinical features, and outcome caused by mdros vs. non-mdros, and identifying risk factors that may predispose patients to sepsis by mdros are important. | 2017 | 28642139 |
| evaluation of microorganisms causing ventilator-associated pneumonia in a pediatric intensive care unit. | the aim of this study was to identify microorganisms causing ventilator-associated pneumonia (vap) and also study the antibiotic resistance/susceptibility. | 2017 | 28638248 |
| identification of 1-((2,4-dichlorophenethyl)amino)-3-phenoxypropan-2-ol, a novel antibacterial compound active against persisters of pseudomonas aeruginosa. | antibiotics typically fail to completely eradicate a bacterial population, leaving a small fraction of transiently antibiotic-tolerant persister cells intact. persisters are therefore seen to be a major cause of treatment failure and greatly contribute to the recalcitrant nature of chronic infections. the current study focused on pseudomonas aeruginosa, a gram-negative pathogen belonging to the notorious eskape group of pathogens (enterococcus faecium, staphylococcus aureus, klebsiella pneumonia ... | 2017 | 28630188 |
| efficacy of cefiderocol against carbapenem-resistant gram-negative bacilli in immunocompetent-rat respiratory tract infection models recreating human plasma pharmacokinetics. | cefiderocol (s-649266), a novel siderophore cephalosporin, shows potent activity against carbapenem-resistant gram-negative bacilli. in this study, we evaluated the efficacy of cefiderocol against carbapenem-resistant gram-negative bacilli (pseudomonas aeruginosa, acinetobacter baumannii, and klebsiella pneumoniae) in immunocompetent-rat respiratory tract infection models recreating plasma pharmacokinetics (pk) profiles in healthy human subjects. a total of 6 clinical isolates (1 cephalosporin-s ... | 2017 | 28630178 |
| patterns of multi-drug resistant bacteria at first culture from patients admitted to a third level university hospital in calabria from 2011 to 2014: implications for empirical therapy and infection control. | surveillance of antimicrobial drug resistance is fundamental to guide empirical treatment. however, the european antimicrobial resistance surveillance network provides a general picture, which might not be applicable to clinical settings that are excluded from this survey. we evaluated resistance patterns of eskape isolates over a four-year period in a third level university hospital in the province of catanzaro (southern italy). in this retrospective study, we evaluated the frequency of eskape ... | 2017 | 28603227 |
| antimicrobial activity, toxicity and anti-inflammatory potential of methanolic extracts of four ethnomedicinal plant species from punjab, pakistan. | the plant species aristolochia indica (ai), melilotus indicus (mi), tribulus terrestris (tt) and cuscuta pedicellata (cp) are widely used in folk medicine in the villages around chowk azam, south punjab, pakistan. the aim of this study was to evaluate the antioxidant activity, phytochemical composition, and the antibacterial, antifungal, cytotoxic and anti-inflammatory potential of the four medicinal plants listed above. for cp stem, this study represents (to the best of our knowledge) the first ... | 2017 | 28595608 |
| a genoproteomic approach to detect peptide markers of bacterial respiratory pathogens. | rapid identification of respiratory pathogens may facilitate targeted antimicrobial therapy. direct identification of bacteria in bronchoalveolar lavage (bal) by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry is confounded by interfering substances. we describe a method to identify unique peptide markers of 5 gram-negative bacteria by liquid chromatography-tandem mass spectrometry (lc-ms/ms) for direct pathogen identification in bal. | 2017 | 28588123 |
| evaluation of the in vitro antimicrobial activity of selected saudi scorpion venoms tested against multidrug-resistant micro-organisms. | scorpion venoms are a rich source of bioactive peptides with promising clinical value that may lead to the discovery and development of new drugs. the present study was designed to evaluate the in vitro antimicrobial activities of the venoms extracted from three medically important saudi scorpions (androctonus crassicauda, androctonus bicolor and leiurus quinquestriatus). | 2017 | 28587870 |
| bacteria from animals as a pool of antimicrobial resistance genes. | antimicrobial agents are used in both veterinary and human medicine. the intensive use of antimicrobials in animals may promote the fixation of antimicrobial resistance genes in bacteria, which may be zoonotic or capable to transfer these genes to human-adapted pathogens or to human gut microbiota via direct contact, food or the environment. this review summarizes the current knowledge of the use of antimicrobial agents in animal health and explores the role of bacteria from animals as a pool of ... | 2017 | 28587316 |
| properties of probiotics kocuria sm1 and rhodococcus sm2 isolated from fish guts. | this study characterized probiotics kocuria sm1 and rhodococcus sm2, which were recovered from the intestinal microbiota of rainbow trout (oncorhynchus mykiss, walbaum). the cultures were gram-positive, non-motile, catalase-positive and oxidase-negative cocci or rods. cell multiplication of sm1 and sm2 was observed at 4-37 °c (45 °c for sm1), in 0-20% (w/v) nacl and at ph 2-11. the viability was not affected when exposed to pepsin at ph 2.0 and 3.0, and pancreatin at ph 8.0. neither isolates wer ... | 2017 | 28585158 |
| effectiveness of cleaning-disinfection wipes and sprays against multidrug-resistant outbreak strains. | hospital rooms play an important role in the transmission of several health care-associated pathogens. during the last few years, a number of innovative cleaning-disinfecting products have been brought to market. in this study, commercially available products combining cleaning and disinfection were compared, using 2 different application methods. the aim was to determine which product was most effective in simultaneous cleaning and disinfection of surfaces. | 2017 | 28571980 |
| site-specific his/asp phosphoproteomic analysis of prokaryotes reveals putative targets for drug resistance. | phosphorylation of amino acid residues on proteins is an important and common post-translational modification in both eukaryotes and prokaryotes. most research work has been focused on phosphorylation of serine, threonine or tyrosine residues, whereas phosphorylation of other amino acids are significantly less clear due to the controversy on their stability under standard bioanalytical conditions. | 2017 | 28545444 |
| [clinical and microbiological study of catheter-associated urinary tract infections in internal medicine services of a venezuelan university hospital]. | to determine the clinical and microbiological characteristics of catheter-associated urinary tract infections (ca-uti) in patients admitted to the internal medicine services of the hospital universitario de los andes (hula), mérida, venezuela and to establish the clonal distribution of multi-resistant enterobacteriaceae that produce this infection. | 2017 | 28538846 |
| celecoxib enhances the efficacy of low-dose antibiotic treatment against polymicrobial sepsis in mice and clinical isolates of eskape pathogens. | treatment of multidrug resistant bacterial infections has been a great challenge globally. previous studies including our study have highlighted the use of celecoxib, a non-steroidal anti-inflammatory drug in combination with antibiotic has decreased the minimal inhibitory concentration to limit staphylococcus aureus infection. however, the efficacy of this combinatorial treatment against various pathogenic bacteria is not determined. therefore, we have evaluated the potential use of celecoxib i ... | 2017 | 28533769 |
| potentiation of antibiotic activity by a novel cationic peptide: potency and spectrum of activity of spr741. | novel approaches for the treatment of multidrug-resistant gram-negative bacterial infections are urgently required. one approach is to potentiate the efficacy of existing antibiotics whose spectrum of activity is limited by the permeability barrier presented by the gram-negative outer membrane. cationic peptides derived from polymyxin b have been used to permeabilize the outer membrane, granting antibiotics that would otherwise be excluded access to their targets. we assessed the in vitro effica ... | 2017 | 28533232 |
| antimicrobial consumption, costs and resistance patterns: a two year prospective study in a romanian intensive care unit. | due to the vulnerable nature of its patients, the wide use of invasive devices and broad-spectrum antimicrobials used, the intensive care unit (icu) is often called the epicentre of infections. in the present study, we quantified the burden of hospital acquired pathology in a romanian university hospital icu, represented by antimicrobial agents consumption, costs and local resistance patterns, in order to identify multimodal interventional strategies. | 2017 | 28532467 |
| biofilm is a major virulence determinant in bacterial colonization of chronic skin ulcers independently from the multidrug resistant phenotype. | bacterial biofilm is a major factor in delayed wound healing and high levels of biofilm production have been repeatedly described in multidrug resistant organisms (mdros). nevertheless, a quantitative correlation between biofilm production and the profile of antimicrobial drug resistance in delayed wound healing remains to be determined. microbial identification, antibiotic susceptibility and biofilm production were assessed in 135 clinical isolates from 87 patients. gram-negative bacteria were ... | 2017 | 28513576 |
| differences in antimicrobial consumption, prescribing and isolation rate of multidrug resistant klebsiella pneumoniae, pseudomonas aeruginosa and acinetobacter baumannii on surgical and medical wards. | in order to provide guidance data for clinically rational use of an antibiotics consuption, prescribing and prevalence of multidrug resistant (mdr) klebsiella pneumoniae, pseudomonas aeruginosa and acinetobacter baumannii were monitored on the surgical (s) and medical (m) wards of the university hospital center "dr. dragisa misovic-dedinje" (belgrade, serbia), in the study period from 2012 to 2015. appropriateness of antimicrobial use was evaluated using the global-prevalence survey method desig ... | 2017 | 28467437 |
| simple and fast detection of resistance to antibiotic inhibitors of protein synthesis in gram-negative pathogens through evaluation of mitomycin c-induced cell elongation. | increasing the resistance of gram-negative pathogens to antibiotics that inhibit protein synthesis is of great concern. in life-threatening situations, an early detection of antibiotic resistance may improve patient outcome. a rapid assay for the identification of antibiotic resistance to gentamicin, tobramycin, and tigecycline has been designed and tested in clinical strains of acinetobacter baumannii, pseudomonas aeruginosa, and the enterobacteriaceae escherichia coli and klebsiella pneumoniae ... | 2017 | 28467172 |
| synthesis and biological evaluation of indole core-based derivatives with potent antibacterial activity against resistant bacterial pathogens. | the emergence of drug resistance in bacterial pathogens is a growing clinical problem that poses difficult challenges in patient management. to exacerbate this problem, there is currently a serious lack of antibacterial agents that are designed to target extremely drug-resistant bacterial strains. here we describe the design, synthesis and antibacterial testing of a series of 40 novel indole core derivatives, which are predicated by molecular modeling to be potential glycosyltransferase inhibito ... | 2017 | 28465626 |
| characterization of the polymyxin d synthetase biosynthetic cluster and product profile of paenibacillus polymyxa atcc 10401. | the increasing prevalence of polymyxin-resistant bacteria has stimulated the search for improved polymyxin lipopeptides. here we describe the sequence and product profile for polymyxin d nonribosomal peptide synthetase from paenibacillus polymyxa atcc 10401. the polymyxin d synthase gene cluster comprised five genes that encoded abc transporters (pmxc and pmxd) and enzymes responsible for the biosynthesis of polymyxin d (pmxa, pmxb, and pmxe). unlike polymyxins b and e, polymyxin d contains d-se ... | 2017 | 28463513 |
| the use of bloodstream infection mortality to measure the impact of antimicrobial stewardship interventions: assessing the evidence. | this review sets out to evaluate the current evidence on the impact of inappropriate therapy on bloodstream infections (bsi) and associated mortality. based on the premise that better prescribing practices should result in better patient outcomes, bsi mortality may be a useful metric to evaluate antimicrobial stewardship (ams) interventions. a systematic search was performed in key medical databases to identify papers published in english between 2005 and 2015 that examined the association betwe ... | 2017 | 28458799 |
| structure, genetics and worldwide spread of new delhi metallo-β-lactamase (ndm): a threat to public health. | the emergence of carbapenemase producing bacteria, especially new delhi metallo-β-lactamase (ndm-1) and its variants, worldwide, has raised amajor public health concern. ndm-1 hydrolyzes a wide range of β-lactam antibiotics, including carbapenems, which are the last resort of antibiotics for the treatment of infections caused by resistant strain of bacteria. | 2017 | 28449650 |
| copper complexes containing thiosemicarbazones derived from 6-nitropiperonal: antimicrobial and biophysical properties. | a series of four thiosemicarbazones from 6-nitropiperonal along with the corresponding copper complexes were synthesized. the biophysical characteristics of the complexes were investigated by the binding to dna and human serum albumin. the binding to dna is moderate; the binding constants run from (0.49-7.50)×10(4)m(-1). in relation to hsa, the complexes interact strongly with binding constants on the order of 10(5)m(-1). the complexes also display antioxidant behavior as determined by the abili ... | 2017 | 28448954 |
| evaluation of six phenotypic methods for the detection of carbapenemases in gram-negative bacteria with characterized resistance mechanisms. | we compared the performance of the modified hodge test (mht), triton hodge test (tht), carba np test (cnpt), simplified carba np test (cnpt-direct), blue-carba np test (bct), and carbapenem inactivation method (cim) for rapid and accurate carbapenemase detection. | 2017 | 28445009 |
| resistance profiles and risk factors of resistant microorganisms in bacteraemia of abdominal origin. | the presence of resistant microorganisms is a major cause of failure in initial empirical antimicrobial therapy. the objectives of this study are to determine the resistance profile of microorganisms that cause bacteraemia of abdominal origin and to identify whether the previous use of antibiotics and the place of acquisition of bacteraemia are risk factors associated with the presence of resistant organisms. | 2017 | 28434558 |
| [epidemiological surveillance for multidrug-resistant microorganisms in a general icu]. | multidrug resistant (mdr) microorganisms represent a threat for patients admitted in intensive care units (icus). the objective of the present study is to analyse the results of epidemiological surveillance cultures for these microorganisms in one of these units. | 2017 | 28422471 |
| resistance among gram-negative eskape pathogens isolated from hospitalized patients with intra-abdominal and urinary tract infections in latin american countries: smart 2013-2015. | gram-negative eskape pathogens (klebsiella pneumoniae, acinetobacter baumannii, pseudomonas aeruginosa, and enterobacter species) are important etiologic agents of nosocomial infection that are frequently resistant to broad-spectrum antimicrobial agents. gram-negative eskape pathogens were collected from hospitalized patients in 11 latin american countries from 2013 to 2015 as part of the study for monitoring antimicrobial resistance trends (smart) global surveillance program. in total, 2113 iso ... | 2017 | 28399424 |
| epidemiology and trends in the antibiotic susceptibilities of gram-negative bacilli isolated from patients with intra-abdominal infections in the asia-pacific region, 2010-2013. | this study was conducted to investigate the epidemiology and antimicrobial susceptibility patterns of gram-negative bacilli (gnb) isolated from intra-abdominal infections (iais) in the asia-pacific region (apr) from 2010-2013. a total of 17 350 isolates were collected from 54 centres in 13 countries in the apr. the three most commonly isolated gnb were escherichia coli (46.1%), klebsiella pneumoniae (19.3%) and pseudomonas aeruginosa (9.8%). overall, the rates of extended-spectrum β-lactamase (e ... | 2017 | 28435019 |
| an unusual culprit: klebsiella pneumoniae causing septicaemia outbreaks in neonatal pigs? | this study investigated the cause of recent outbreaks of septicaemia in neonatal pigs in australia (victoria and queensland). septicaemia in neonatal pigs is commonly caused by enterotoxigenic e. coli, extraintestinal pathogenic e. coli and beta-haemolytic streptococci. infrequent causes of septicaemia are actinobacillus suis and citrobacter freundii. therefore, it was quite unexpected when klebsiella pneumoniae was isolated in predominant growth from multiple organs of pigs dying of septicaemia ... | 2017 | 28619154 |
| novel plasmid-mediated colistin resistance gene mcr-3 in escherichia coli. | the mobile colistin resistance gene mcr-1 has attracted global attention, as it heralds the breach of polymyxins, one of the last-resort antibiotics for the treatment of severe clinical infections caused by multidrug-resistant gram-negative bacteria. to date, six slightly different variants of mcr-1, and a second mobile colistin resistance gene, mcr-2, have been reported or annotated in the genbank database. here, we characterized a third mobile colistin resistance gene, mcr-3 the gene coexisted ... | 2017 | 28655818 |
| production, characterization, and antimicrobial activity of mycocin produced by debaryomyces hansenii dsmz70238. | the present study was conducted to estimate the antimicrobial activity and the potential biological control of the killer toxin produced by d. hansenii dsmz70238 against several pathogenic microorganisms. in this study, the effects of nacl, ph, and temperature, killer toxin production, and antimicrobial activity were studied. the results showed that the optimum inhibitory effect of killer toxin was at 8% nacl, and the diameters of clear zones were 20, 22, 22, 21, 14, and 13 mm for staphylococcus ... | 2017 | 28757872 |
| recovery of metallo-tolerant and antibiotic resistant psychrophilic bacteria from siachen glacier, pakistan. | cultureable bacterial diversity of previously unexplored siachen glacier, pakistan, was studied. out of 50 isolates 33 (66%) were gram negative and 17 (34%) gram positive. about half of the isolates were pigment producers and were able to grow at 4-37°c. 16s rrna gene sequences revealed gram negative bacteria dominated by proteobacteria (especially γ-proteobacteria and β-proteobacteria) and flavobacteria. the genus pseudomonas (51.51%, 17) was dominant among γ- proteobacteria. β-proteobacteria c ... | 2017 | 28746396 |
| evaluation of anthelmintic antimicrobial and antioxidant activity of chenopodium album. | the objective of this study was to evaluate the anthelmintic, antimicrobial and antioxidant activities of chenopodium album against gastrointestinal nematodes of sheep and some pathogenic microbes. a worm motility inhibition assay was used for in vitro study, and a faecal egg count reduction assay was used for an in vivo study. various concentrations ranging from 100 to 500 μg/ml of the extract were subjected to antimicrobial screening by disc diffusion method against four selected bacterial (st ... | 2017 | 28735356 |
| characteristics of meningitis following transsphenoidal endoscopic surgery: a case series and a systematic literature review. | meningitis occurs in 0.8-1.5% of patients undergoing neurosurgery. the aim of the study was to evaluate the characteristics of meningitis after endoscopic endonasal transsphenoidal surgery (eets) comparing the findings retrieved to those highlighted by literature search. | 2017 | 28776163 |
| antimicrobial activity of endophytic bacterial populations isolated from medical plants of iran. | endophytic actinobacteria colonize inside the plant tissues without causing damages to the host plant. since these microorganisms colonize in the different parts of plants and can stop plant disease, they have been applied as biological agents for controlling human diseases. the aim of this study was molecular identification and measuring the antimicrobial activity of endophytic actinomycetes isolated from medicinal plants of iran. | 2017 | 28775818 |
| cyclohexene-fused 1,3-oxazines with selective antibacterial and antiparasitic action and low cytotoxic effects. | oxazine derivatives, a class of heterocyclic compounds, exhibit a variety of biological properties, such as anticonvulsant and antitumor activities. in this study, we evaluated the effect of two cyclohexene-fused 1,3-oxazines (cis‑1-benzyl-n-phenyl-1,4,4a,5,8,8a-hexahydro-3,1-benzoxazin-2-imine (1) and trans‑n-phenyl-1,4,4a,5,8,8a-hexahydro-3,1-benzoxazin-2-imine (2)) in cultures of bacillus cereus, enterococcus faecalis, escherichia coli, klebsiella pneumoniae, salmonella enterica, serratia mar ... | 2017 | 28755871 |
| isolation, morphological identification and in vitro antibacterial activity of endophytic bacteria isolated from azadirachta indica (neem) leaves. | the objective of this study was to isolate endophytic bacteria from azadirachta indica (neem) leaves, their identification and investigate their antibacterial activity against three gram-positive bacteria, staphylococcus aureus, streptococcus pyogenes and bacillus cereus and gram-negative bacteria escherichia coli, salmonella typhimurium and klebsiella pneumoniae. | 2017 | 28620254 |
| an enhancement of antimicrobial efficacy of biogenic and ceftriaxone-conjugated silver nanoparticles: green approach. | of the various methods explored for the synthesis of nanoparticles, biogenesis of silver nanoparticles (agnps) received great attention due to their versatile properties. in this report, daucus carota extract was used for the synthesis of agnps and ceftriaxone was conjugated with agnps to enhance their antimicrobial efficacy. the conjugated and unconjugated agnps were characterized by adopting uv-vis spectroscopy, ftir, afm, dls, and tem, which revealed the spr peak at 420 nm and spherical shape ... | 2017 | 28600792 |
| phosphate crosslinked pectin based dual responsive hydrogel networks and nanocomposites: development, swelling dynamics and drug release characteristics. | potential dual responsive hydrogel networks (ppad) are fabricated from pectin, poly((2-dimethylamino)ethyl methacrylate)) and phosphate crosslinker bis[2-methacryloyloxy] ethyl phosphate (bmep) by a simple free radical polymerization. these hydrogel networks are successfully utilized for encapsulation of an anti-cancer drug, 5-fluorouracil (5-fu) and also employed as versatile platforms for production of silver nanoparticles. fabricated hydrogel networks and silver nanocomposites were characteri ... | 2017 | 28576553 |
| heteroleptic metal(ii) complexes of hydrotris(methimazolyl)borate and diimines: synthesis, theoretical calculations, antimicrobial, antioxidant, in vitro cytotoxicity and molecular docking studies. | a series of heteroleptic metal(ii) complexes of formulation [m(tm)(diimine)](clo4) (1-8), [tm = hydrotris(methimazolyl)borate, diimine = 2,2'-bipyridyl or 1,10-phenanthroline and m = mn(ii), ni(ii), cu(ii) or zn(ii)] have been synthesized and characterized by spectroscopic methods. the geometric parameters of the complexes were determined using uv-vis spectroscopy and dft calculations. the analyses of homo and lumo have been used to explain the charge transfer within the molecule. antimicrobial ... | 2017 | 28546116 |
| paneth-cell-disruption-induced necrotizing enterocolitis in mice requires live bacteria and occurs independently of tlr4 signaling. | necrotizing enterocolitis (nec) remains a leading cause of morbidity and mortality in premature infants. both human surgical specimens and animal models suggest a potential involvement of paneth cells in nec pathogenesis. paneth cells play critical roles in epithelial homeostasis, innate immunity and host-microbial interactions. yet, the complex interplay between paneth cell disruption, epithelial barrier dysfunction and microbial-driven inflammation remains unclear in the immature intestine. in ... | 2017 | 28450472 |
| molecular characterization and functional analysis of the hepcidin gene from roughskin sculpin (trachidermus fasciatus). | hepcidin is a kind of cysteine-rich antimicrobial peptide that plays a vital role in host innate immune activity and iron regulation. here, we report the molecular characterization and functional analysis of a novel hamp1 hepcidin isoforms tf-hep from roughskin sculpin, trachidermus fasciatus. a cdna fragment of 988 bp with an orf of 273 bp was obtained. the coding sequence encodes for a signal peptide of 24 amino acids coupled with a prodomain of 40 amino acids and a mature peptide of 26 amino ... | 2017 | 28743631 |
| in vitro antimicrobial activity screening of xylaria hypoxylon. | fungi have a potential of using both as nutritive and medicinal food stuff. because of containing several therapeutic agents, they are reported to be used for hundreds of years to treat several diseases caused by bacteria, fungi, viruses and parasites. the aim of this study is to determine the in vitro antimicrobial activity of xylaria hypoxylon, which were collected from yomra, trabzon, turkey. | 2016 | 28852719 |
| an assessment on the role of endophytic microbes in the therapeutic potential of fagonia indica. | natural products of animals, plants and microbes are potential source of important chemical compounds, with diverse applications including therapeutics. endophytic bacteria that are especially associated with medicinal plants presents a reservoir of therapeutic compounds. fagonia indica has been recently investigated by numerous researchers because of its striking therapeutic potential especially in cancer. it is also reported that endophytes play a vital role in the biosynthesis of various meta ... | 2017 | 28764775 |
| a prospective randomised trial of isolated pathogens of surgical site infections (ssi). | every surgical wound is colonized by bacteria, but only a small percentage displays symptoms of infection. the distribution of pathogens isolated in surgical site infections has not significantly changed over the last decades. staph. aureus, coag(-) staphylococci, enterococcus spp and e. coli are the main strains appearing. in addition, a continuously rising proportion of surgical site infections caused by resistant bacterial species (mrsa, c. albicans) has been reported. | 2017 | 28761643 |
| optimization of cord blood unit sterility testing: impact of dilution, analysis delay, and inhibitory substances. | different methods are used by cord blood banks to prepare samples for sterility testing. suboptimal methods can result in the release of contaminated products. in our organization, samples are prepared by diluting the final product in rpmi-1640 medium. in this work, we have compared our method with different approaches to verify whether optimization should be sought. | 2017 | 28474347 |
| what the eyes don't see, the heart does grieve over. | a 71 year old peruvian woman presented with blurry vision and bilateral eye pain and had evidence of bilateral endophthalmitis on eye examination. her past medical history was notable for multiple abdominal surgeries within the preceding months, including an incarcerated inguinal hernia repair which required an ileostomy placement, and cholecystitis requiring cholecystostomy tube placement. over her multiple long hospitalizations, she developed bacteremia and fungemia on several occasions, with ... | 2017 | 28414678 |
| simultaneous detection of 13 key bacterial respiratory pathogens by combination of multiplex pcr and capillary electrophoresis. | lower respiratory tract infections continue to pose a significant threat to human health. it is important to accurately and rapidly detect respiratory bacteria. to compensate for the limits of current respiratory bacteria detection methods, we developed a combination of multiplex polymerase chain reaction (pcr) and capillary electrophoresis (mpce) assay to detect thirteen bacterial pathogens responsible for lower respiratory tract infections, including streptococcus pneumoniae, haemophilus influ ... | 2017 | 28807095 |
| bacterial bloodstream infections in a tertiary infectious diseases hospital in northern vietnam: aetiology, drug resistance, and treatment outcome. | bloodstream infections (bsis) are associated with high morbidity and mortality worldwide. however their aetiology, antimicrobial susceptibilities and associated outcomes differ between developed and developing countries. systematic data from vietnam are scarce. here we present aetiologic data on bsi in adults admitted to a large tertiary referral hospital for infectious diseases in hanoi, vietnam. | 2017 | 28701159 |
| chemical and antimicrobial analyses of sideritis romana l. subsp. purpurea (tal. ex benth.) heywood, an endemic of the western balkan. | a comprehensive study on essential oil and different solvent extracts of sideritis romana l. subsp. purpurea (tal. ex benth.) heywood (lamiaceae) from montenegro is reported. the gas chromatography-mass spectrometry analysis of the essential oil revealed a total of 43 components with bicyclogermacrene (23.8%), germacrene d (8%), (e)-caryophyllene (7.9%) and spathulenol (5.5%) as the major ones. sesquiterpenoid group was found to be the most dominant one (64.8%), with 19.9% of the oxygenated form ... | 2017 | 28832536 |
| investigation of effect of 1,8-cineole on antimicrobial activity of chlorhexidine gluconate. | chlorhexidine belongs to a group of medicines called antiseptic antibacterial agents. chlorhexidine is commonly used for the care and clean off the skin, hands, and wounds. in recent years, medicinal and aromatic plants have been used for prevention of disease, maintaining health, and improving disease in traditional and modern medicine as a medicament. according to recent research, cineole is the isolated active agent of eucalyptus oil and possesses antimicrobial activity. it was demonstrated t ... | 2017 | 28827963 |
| [to the state of the fetoplacental complex in women with the threat of abortion]. | the goal is a comprehensive study of the morphofunctional state of the mother-placenta-fetus system in placental insufficiency and infection. 250 pregnant and puerperas for the period 2008-2014 were examined. detection of bacterial flora was carried out in 35 pregnant women aged 20.4±0.8 years with the threat of abortion from an early gestation period and a prolonged persistent infection of the genitals, bacterial vaginosis. methods are applied: culture, ion chromatography, gas-liquid chromatogr ... | 2017 | 28820412 |
| risk factors and predictors of mortality of candidaemia among critically ill patients: role of antifungal prophylaxis in its development and in selection of non-albicans species. | the aim of the present study is to identify risk factors for development and predictors of mortality of candidaemia among critically ill patients. | 2017 | 28756598 |
| antimicrobial, modulatory and chemical analysis of the oil of croton limae. | croton sp. are plants with a well-reported antimicrobial activity. croton limae a.p. gomes, m.f. sales p.e. berry (euphorbiaceae), known as 'marmeleiro-prateado', is commonly used to manage abdominal pain in brazil. | 2017 | 28738715 |
| the antimicrobial spectrum of xeroform(®). | xeroform(®) is a petrolatum-based fine mesh gauze containing 3% bismuth tribromophenate. bismuth, similar to other metals, has antimicrobial properties. xeroform(®) has been used for decades in burn and plastic surgery as a donor site dressing and as a covering for wounds or partial thickness burns. despite this, the antimicrobial spectrum of xeroform(®) remains largely unknown. we examined the in-vitro efficacy of xeroform(®) against common burn pathogens using zone-of-inhibition methodology in ... | 2017 | 28641915 |
| synthesis and evaluation of arylamidine derivatives for new antimicrobial and cytotoxic activities. | a series of arylamidines 3a-j was designed, synthesized and investigated for antimicrobial activity. structures of the compounds were confirmed by ir, 1h-nmr and 13c-nmr and a 2d spectroscopic study was performed. a preliminary screening of the antimicrobial tests clearly showed that three out of ten arylamidines, viz, 3f, 3g and 3i, were effective against all the gram-negative bacteria: klebsiella pneumoniae, pseudomonas aeruginosa and salmonella enteric; and against the yeast, candida albicans ... | 2017 | 28640352 |
| association between pathogens from tracheal aspirate and oral biofilm of patients on mechanical ventilation. | the aim of this study was to detect possible associations between respiratory pathogens from tracheal aspirate and oral biofilm samples in intubated patients in an intensive care unit (icu), and to identify the most common respiratory pathogens in oral biofilm, particularly in patients that developed ventilator-associated pneumonia (vap). two oral biofilm samples were collected from the tongue of intubated patients (at admission and after 48 hours) and analyzed by culture with the antibiotic sen ... | 2017 | 28591237 |
| in vitro antimicrobial potential of extracts and phytoconstituents from gymnema sylvestre r.br. leaves and their biosafety evaluation. | the in vitro antimicrobial screening of gymnema sylvestre leaves against 13 test pathogens established its broad spectrum activity with average inhibition zone ranging from 14 to 23 mm. the antimicrobial activity of the classically- optimized aqueous extract was enhanced up to 1.45 folds, when subjected to statistical optimization using response surface methodology (rsm) and was thermostable. ethyl acetate was found to be the best organic extractant with klebsiella pneumoniae 1 (31.5 mm) and sta ... | 2017 | 28587443 |
| time-kill kinetics and biocidal effect of euclea crispa leaf extracts against microbial membrane. | to evaluate antimicrobial potential of the fractions partitioned from euclea crispa leaf extract and determination of their impact on cell membrane disruption. | 2017 | 28552109 |
| investigation of antioxidant, antimicrobial and toxicity activities of lichens from high altitude regions of nepal. | several lichen species are reported to be used tradiationally in many theraupatic practices. many lichen species are reported as sources of several bioactive natural compounds. several lichen species of nepal are so far chemically unexplored. | 2017 | 28545438 |