| recognition of a category of responders to group ii, slow-grower associated antigens amongst kuwaiti senior school children, using a statistical model. | a mathematical model previously developed to test the validity of categorisation of skin test responders has been applied to data obtained from 3 age groups of kuwaiti school children. two specially designed sets of 4 new tuberculins were tested on senior school children to determine whether extra categories of responders might exist amongst them. strong statistical evidence has been obtained that a proportion of the children respond to group ii, slow-grower associated antigen, creating a fourth ... | 1988 | 3151531 |
| sensitisation by mycobacteria and the effects of bcg on children attending schools in the slums of bombay. | quadruple skin testing with new tuberculins was used to evaluate the effects of previously administered bcg madras in children attending schools in the slums, or living in kopri leprosy colony in bombay. there were differences between schools both in the level of sensitisation of children without bcg scars and in the effects of bcg vaccination. results obtained at one school resembled those obtained in a previous study in agra, where bcg was thought to be ineffective. results from the other scho ... | 1988 | 3151532 |
| [prospective study of the primary resistance of the tuberculosis bacillus to antibiotics. methods and results]. | | 1988 | 3151751 |
| current antimicrobial management of tuberculosis. | | 1987 | 3151759 |
| [development of a test-system of immunoenzyme analysis for serodiagnosis of tuberculosis in extra-pulmonary sites]. | | 1988 | 3152018 |
| [the present attitude to chemotherapy in tuberculosis in adults]. | | 1987 | 3152080 |
| association between km1 immunoglobulin allotype and pulmonary tuberculosis in indonesians. | allotypes were determined in 121 cases of smear-positive pulmonary tuberculosis and 33 healthy controls from indonesia. it was found that the occurrence of km1 was significantly lower in patients than in controls (p = 0.011), and that phenotypes lacking g1m (17) and g3m(21) as well as km1 occurred much more frequently among patients than controls (p = 0.0025). some evidence for an allotypic influence on the antibody response to mycobacterial antigens was found. a lack of g1m(17) or g3m(21) was a ... | 1987 | 3152540 |
| isolation of mycobacterium species from cases of cervical lymphadenitis. | | 1987 | 3152562 |
| towards new leprosy and tuberculosis vaccines. | leprosy and tuberculosis are chronic infectious diseases causing major global health problems, for which no effective control by vaccination has been achieved. recent advances in biotechnology may facilitate the design of a new vaccine generation. in this paper the need for, and the potential of, leprosy and tuberculosis vaccines are discussed. | 1987 | 3155274 |
| [results of inspection of bacteriological laboratories with regard to identification of mycobacteria]. | | 1985 | 3157188 |
| [use of fluorescence microscopy in a district tuberculosis dispensary]. | | 1985 | 3159002 |
| in vitro activity of ciprofloxacin against mycobacteria. | | 1985 | 3160585 |
| [antimycobacterial activities of minocycline and ciprofloxacin]. | | 1985 | 3162057 |
| [unusual healing of tendon sheath tuberculosis by intercurrent streptococcal phlegmon]. | tuberculosis of the flexor tendon sheaths in western industrial countries is rare. the author presents a case with an exceptional course and an unexpected outcome. a sixty-five year old woman suffered from tuberculosis of the flexor tendon sheath of her little finger. appropriate tuberculostatic treatment was impossible due to damage of liver cells by chronic hepatitis. an open wound with positive cultures of mycobacterium tuberculosis persisted over eight months despite local and systemic treat ... | 1988 | 3169638 |
| new nonsurgical technique for multiple pericardial biopsies. | we report a new, nonsurgical technique for obtaining multiple pericardial biopsies in patients with pericardial effusion. a short catheter is introduced by the seldinger technique under fluoroscopy through the subxiphoid approach. the pericardial fluid is aspirated and the catheter replaced by an 8f teflon sheath with a curved tip. a bioptome is inserted through the sheath, and air is allowed to enter the pericardium. this method outlines the parietal percardium. the curved sheath directs the bi ... | 1988 | 3180214 |
| qualitative and quantitative drug-susceptibility tests in mycobacteriology. | qualitative methods of susceptibility testing have been employed widely around the world during the last 37 years and have proved to be a generally reliable tool to guide the chemotherapy of tuberculosis with conventional antituberculosis drugs. however, we believe there is a need now for application of modern quantitative methods to mycobacteriology: (1) for susceptibility testing of mycobacterium avium complex, (2) for evaluation of the bactericidal activity of the antimycobacterial drugs, (3) ... | 1988 | 3195815 |
| studies on the epidemiology of nontuberculous mycobacteriosis in japan. | the epidemiology of mycobacterial disease in japan changed considerably over the period 1971 to 1984. during this time, the incidence of pulmonary disease caused by mycobacterium tuberculosis has steadily declined; disease caused by m. avium complex has remained stable; disease caused by m. kansasii has increased considerably; and, for the first time, substantial numbers of cases caused by m. szulgai, m. fortuitum, m. chelonae, and m. nonchromogenicum have been reported. from 1981 to 1984 the in ... | 1988 | 3202368 |
| tuberculous meningitis: a retrospective survey of 22 cases. | clinical and biological findings likely to constitute prognostic factors were analyzed in a retrospective survey of 22 cases of tuberculous meningitis. in particular, associations between clinical and biological findings (clinical grade on admission, normal and abnormal csf protein and glucose values) and outcome of illness were sought. on admission 16 patients had altered consciousness, 11 hemiparesis and 7 sixth cranial nerve paresis. meningeal signs were present in all subjects. 7 had a posit ... | 1988 | 3215749 |
| metabolism of the tma group of antigens during the growth cycle of mycobacteria. | the tma (thermostable macromolecular antigens) group includes a60 of mycobacterium tuberculosis and a7 of m. leprae, active components of tuberculin and lepromin. we have previously described the purification and composition of a60, and its ability to elicit immune reactions of humoral and cellular type. in the present work, the intracellular and extracellular distribution and composition of a60 have been traced, as a function of the replication cycle, in static surface cultures of m. bovis. in ... | 1988 | 3216816 |
| diterpenoids from the roots of salvia hypargeia. | from the root extracts of salvia hypargeia, in addition to the known diterpenoids cryptanol and horminone, six new abietane diterpenoids were isolated. the structures of the new and the known compounds were established by spectral data. the new compounds, hypargenins a, b, c, d, and f, showed antibacterial activity, while hypargenin f was also active against mycobacterium tuberculosis. hypargenin e did not exhibit antibacterial activity. | 1988 | 3236010 |
| in-vitro activity of seventeen antimicrobial compounds against seven species of mycobacteria. | within attainable serum concentrations, quinolones, especially ciprofloxacin, inhibited strains of mycobacterium tuberculosis, m. xenopi, m. kansasii, m. fortuitum and m. marinum; vancomycin inhibited m. tuberculosis, the m. avium-intracellulare-scrofulaceum complex. m. kansasii, m. xenopi and m. chelonei; erythromycin was active against m. kansasii, m. xenopi and m. fortuitum, minocycline against m. kansasii and m. marinum and netilmicin and cefuroxime against m. xenopi. aztreonam showed some a ... | 1988 | 3243734 |
| the protective and allergenic potency of four bcg substrains in use in china determined in two animal models. | the objective of this study was to compare four bcg substrains from regional centres in china with bcg-copenhagen 1331 (danish strain) for protective and allergenic potencies. the comparisons were made in two different guinea pig models: one, a rational animal model involving aerosol challenge with 5-10 cfu mycobacterium tuberculosis (strain h37rv), and the other an animal model involving subcutaneous challenge with 250 cfu of h37rv. for either model, the degree of protection was judged by quant ... | 1988 | 3257006 |
| an analysis of in vitro t cell responsiveness in nontuberculous mycobacterial infection. | in vitro cell-mediated immunity was examined in patients infected with nontuberculous mycobacteria, mycobacterium avium-intracellulare complex in japan. peripheral blood lymphocytes of patients, as compared with those of tuberculous patients or tuberculin-positive healthy donors, showed depressed in vitro blastogenic responses to purified protein derivative of tuberculin (ppd), not only to ppds of mycobacterium tuberculosis but also to ppd-b and ppd-y of m intracellulare and m kansasii, respecti ... | 1988 | 3262490 |
| immunogenetic analysis of human tuberculosis. | an investigation was undertaken to determine if susceptibility and/or immune response to mycobacterium tuberculosis was associated with histocompatible leukocyte antigen (hla) phenotype frequencies of class i or ii antigens. comparisons of the hla phenotypes of 51 mexican-american patients with tuberculosis and 54 healthy subjects who differed in their skin-test reactivity to purified protein derivative (ppd) revealed that hla-dr3 was significantly decreased in patients with tuberculosis, compar ... | 1988 | 3264314 |
| diversity in migration of cd4 and cd8 lymphocytes in different microanatomical compartments of the skin in the tuberculin reaction in man. | the lymphocytes in the perivascular foci of tuberculin skin tests have a similar cd4:cd8 ratio to those in the peripheral blood, suggesting that these subsets do not show bias in their initial emigration. by contrast, the diffusely infiltrating lymphocytes show a relative preponderance of cd4 cells which is progressively greater in successive 250 micron layers into the dermis. a generally similar pattern is seen in healthy controls and in patients with untreated pulmonary tuberculosis, treated l ... | 1988 | 3265334 |
| an age-related loss of the isogeneic barrier to the successful passive cell transfer of antimicrobial immunity in mice. | the results of this study show that an isogeneic barrier to the successful adoptive immunotherapy of mycobacterium tuberculosis infected mice is progressively lost as these animals age. this was shown in this study by the demonstration that increasing levels of transferred acquired specific resistance could be conferred on normal old recipients of greater than 22 months of age, whereas in young recipients such transfers were unsuccessful without the prior exposure of recipients to sublethal leve ... | 1988 | 3265750 |
| mycobacteria in public water supplies: comparative resistance to chlorine. | the isolation of mycobacteria from municipal and hospital water supplies prompted an investigation of the susceptibility of environmental and clinical isolates of mycobacteria other than mycobacterium tuberculosis and mycobacterium bovis to free chlorine. experiments revealed that free chlorine concentrations of 1.0 mg l-1 eliminated 100,000 c.f.u. of the mycobacterial strains tested within 8 hours of exposure, whereas a concentration of 0.15 mg l-1 had virtually no bacteriocidal effect. free ch ... | 1988 | 3274950 |
| increased infections associated with the use of okt3 for treatment of steroid-resistant rejection in renal transplantation. | we compared the infections encountered in 23 renal transplant patients given the monoclonal anti-t-cell antibody, orthoclone okt3 (okt3), for treatment of steroid-resistant rejection in 1986 and in 23 control patients from 1984 to 1985 with resistant rejection matched demographically, for severity of rejection and for risk factors predisposing to infection, who did not receive okt3; recipients of okt3 received substantially less prednisone, cyclosporine, and antilymphocyte globulin (alg) than co ... | 1988 | 3276066 |
| the immune response to the cell wall of mycobacterium bovis bcg. | mice were immunized with the cell wall of bcg suspended in an oil-in-saline emulsion, and examined against time for the emergence of t cell-mediated acquired immunity. evidence is presented that shows that levels of acquired resistance expressed in these animals over the first month following inoculation, and which enabled them to substantially resist an intravenous challenge infection with mycobacterium tuberculosis, were completely nonspecific in nature, in that they were equally well expresse ... | 1988 | 3289800 |
| mycobacteria other than mycobacterium tuberculosis: review of microbiologic and clinical aspects. | the rate of isolation of mycobacteria other than mycobacterium tuberculosis (mott) has increased over the past several years; in some areas the isolation rate for mycobacterium avium-mycobacterium intracellulare has surpassed that for m. tuberculosis. simultaneously, the spectrum of clinical manifestations with the various species has widened. outbreaks of disease due to mycobacterium chelonae have occurred in renal dialysis patients. new species have been described: mycobacterium malmoense is p ... | 1987 | 3296098 |
| [clinicopathologic conference. heerfordt syndrome in sarcoidosis with simultaneous detection of mycobacterium tuberculosis by bacterial culture]. | | 1987 | 3299026 |
| [pathogen changes in bacterial bone and joint infections (osteomyelitis, spondylitis, arthritis)]. | with regard to germ mutation in osteomyelitis, spondylitis, and arthritis it has been established that the frequency of mycobacterium tuberculosis and the gram-positive pathogens (s. albus, streptococci) has decreased in the last 20 years. to varying degrees, s. aureus and the gram-negative, aerobic organisms are the most important pathogens of bone and joint infections. overall, there has been an increase in the frequency of infections with gram-negative, aerobic organisms. in the majority of c ... | 1987 | 3303720 |
| [determining igg antibodies to mycobacterium tuberculosis antigens in patients with pulmonary tuberculosis by the immunoenzyme analysis method]. | | 1987 | 3306656 |
| limiting dilution analysis of the human t cell response to mycobacterial antigens from bcg vaccinated individuals and leprosy patients. | the number of peripheral blood t lymphocytes responding to soluble mycobacterial antigens from mycobacterium tuberculosis purified protein derivative (ppd) and m. leprae (mls) was estimated by limiting dilution analysis. antigen-induced lymphocyte activation was measured by means of [3h]tdr incorporation on day 10 of culture in the presence of suboptimal concentrations of interleukin 2 (il-2). in the peripheral blood of bcg-vaccinated individuals from the uk, the frequency of t lymphocytes respo ... | 1987 | 3308217 |
| inhibition of phagosome-lysosome fusion in macrophages by certain mycobacteria can be explained by inhibition of lysosomal movements observed after phagocytosis. | we have investigated the mechanism of the inhibition of phagosome-lysosome (p-l) fusion in macrophages known to occur after infection by mycobacterium tuberculosis and by the mouse pathogen mycobacterium microti. we have used an m. microti infection and have studied, first, the saltatory movements of periphagosomal secondary lysosomes by means of visual phase-contrast microscopy (a similar use of the method having been previously supported by computer analyses). the movements became slow or stat ... | 1987 | 3309128 |
| most mycobacterium leprae carbohydrate-reactive monoclonal antibodies are directed to lipoarabinomannan. | each of more than 30 monoclonal antibodies that had been raised against mycobacterium leprae and previously classified as reactive with carbohydrate was shown to be directed against lipoarabinomannan, a prominent, highly pervasive, myo-inositol-phosphate-containing, cross-reactive antigen within the leprosy bacillus. some of the antibodies preferentially bound to the lipopolysaccharide of m. leprae rather than to that of mycobacterium tuberculosis, suggesting the presence of distinguishing struc ... | 1987 | 3312018 |
| murine models for mycobacterioses. | murine models have proven very useful in studying the pathobiology and chemotherapy of a number of mycobacterioses. while there are a number of significant variations from the human model, a substantial body of experience aids in extrapolating from the murine model to the human condition. the most extensively studied infection is mycobacterium tuberculosis. however, there have been significant advances recently using the beige mouse (an immunodeficient mutant) as an acute infection model for dis ... | 1986 | 3317615 |
| hypothesis: a selective advantage for cystic fibrosis heterozygotes. | european populations have both a particularly long history of pulmonary tuberculosis and extremely high frequencies of cystic fibrosis (cf). while carriers of the recessive gene are asymptomatic for cf disease, their fibroblasts produce excessive amounts of hyaluronic acid, whose role in successful isolation of virulent pathogens appears to be especially adaptive in host resistance to the human strain of mycobacterium tuberculosis. cf heterozygosity may have been an adaptation to a disease envir ... | 1987 | 3318490 |
| infections caused by mycobacterium szulgai in humans. | mycobacterium szulgai is a scotochromogenic species that has recently been recognized as a human pathogen. twenty-four cases of disease caused by m. szulgai in humans have been reported in the english-language literature. the clinical features of these cases were reviewed, and three additional cases (two pulmonary, one extrapulmonary) were studied. pulmonary disease indistinguishable from that caused by mycobacterium tuberculosis was the commonest type of infection caused by m. szulgai (18 of 27 ... | 1987 | 3321362 |
| invasive pulmonary aspergillosis: a diagnostic and therapeutic problem. clinical experience with eight haematologic patients. | eight patients with haematologic malignancies contracted fatal invasive aspergillosis during an outbreak. five patients were neutropenic. bronchofiberoscopic examination with microbiology specimen brush and bronchoalveolar lavage yielded aspergillus fumigatus in only 2/5 patients examined. the specific diagnosis reached during lifetime in 5 patients was based on a combination of invasive procedures (lung biopsy in 2, percutaneous lung puncture in 1), the presence of a lung abscess (3 patients), ... | 1987 | 3321414 |
| the dynamics of infection following bcg and mycobacterium tuberculosis challenge in t-cell-deficient mice. | the purpose of these experiments was to re-evaluate the usefulness of the thymectomized, irradiated, bone marrow reconstituted mouse (txb mouse) as a model of the effect of immunodeficiency on resistance to mycobacterial infection. it was found that, although txb mice had no resistance to intravenous infection with mycobacterium tuberculosis, such mice were able to express moderate resistance to infection with the bcg vaccine, even when given in high doses. it is concluded, therefore, that rathe ... | 1987 | 3332058 |
| tuberculous enteritis and peritonitis. | in turkey, diseases associated with mycobacterium tuberculosis are common. intestinal tuberculosis has generally been a complication of pulmonary tuberculosis, but recently there has been an increase in the frequency of intestinal tuberculosis without the pulmonary form. the authors present their experience over 8 years in 41 patients (aged 15 to 56 years) who underwent surgery for tuberculous enteritis (14), peritonitis (13), a combination of the two (5), genital tuberculosis and peritonitis (5 ... | 1988 | 3337974 |
| tuberculous lymphadenitis associated with human immunodeficiency virus (hiv) in uganda. | sixteen adults presented with lymphadenopathy which was tuberculous on biopsy; they were all seropositive for human immunodeficiency virus (hiv-1), but none had the clinical criteria of the acquired immunodeficiency syndrome (aids). the biopsy specimen showed caseating tuberculosis, with scanty or no visible acid fast bacilli in seven cases; the remaining nine had a poor cellular reactivity with numerous bacilli. antituberculous chemotherapy for two months reduced the lymphadenopathy. two patien ... | 1988 | 3343383 |
| a mouse model of the recrudescence of latent tuberculosis in the elderly. | the present study was designed to attempt to construct an animal model of the recrudescence of pulmonary tuberculosis by following the course of infection in mice exposed at 3 months of age to a low dose aerosol of mycobacterium tuberculosis erdman. the results show that such mice died of overwhelming lung disease at a median age of 24 months; in contrast, uninfected mice lived 4 to 6 months longer. examination of infected mice over the period of 20 to 24 months of age provided evidence to sugge ... | 1988 | 3345049 |
| antimycobacterial activities in vitro and in vivo and pharmacokinetics of dihydromycoplanecin a. | the in vitro activity of dihydromycoplanecin a (dhmp a), a new cyclic peptide antibiotic, was compared with those of antimycobacterial drugs such as streptomycin, isoniazid (inh), rifampin, and ofloxacin against several clinically isolated species of mycobacteria, including mycobacterium tuberculosis, m. intracellulare, and m. kansasii. dhmp a demonstrated stronger activities than other drugs against all species of mycobacteria tested at concentrations of less than 0.0125 to 25 microgram/ml. a m ... | 1988 | 3348603 |
| histoplasmosis in patients at risk for the acquired immunodeficiency syndrome in a nonendemic setting. | we reviewed 18 cases of histoplasmosis in patients at risk for the acquired immunodeficiency syndrome seen at two new york city hospitals in the past 3 1/2 years. seventeen patients were hispanic, including 13 born in puerto rico and three in south america. clinical presentation was subacute, with high fever, weight loss, and mild respiratory symptoms with well-maintained gas exchange. five patients had normal chest roentgenograms. the most common chest roentgenographic abnormality was diffuse s ... | 1988 | 3359846 |
| tuberculosis presenting as laryngeal stridor in a child. | a three and a half-year-old boy developed stridor after insertion of grommets for bilateral secretory otitis media. despite treatment with steroids systemically and locally, antibiotics and an antihistamine, the stridor worsened. microlaryngotracheobronchoscopy (mlb) demonstrated laryngeal granulations, in which, by auramine and ziehl-neelsen staining, acid-fast bacilli were seen, and from which subsequently mycobacterium tuberculosis grew in culture. following the mlb the child became comatosed ... | 1988 | 3367057 |
| [tropical aids and tuberculosis. apropos of a survey carried out in bujumbura within the direct setting of hiv-seropositive and -seronegative tuberculous patients]. | during a survey carried out in bujumbura (burundi) within two selected groups of h.i.v. seropositive and h.i.v. seronegative tubercular patients and their respective family, the authors noted that h.i.v. + patients reacted poorly to the specific treatment and they have continued to disseminate mycobacterium tuberculosis after one year of treatment and consequently they have contaminated their family. they often have showed some drug reactions, in particular to tbe 1. | 1988 | 3367761 |
| the acquired immunodeficiency syndrome: a tuberculosis threat? | in the united states there has been an increase in mycobacterial infections that is attributable to the acquired immunodeficiency syndrome (aids). since 1983, when the first case of aids was reported in australia, there have been 523 patients (to june 30, 1987) notified with group-iv aids and, of these, 361 (69%) cases have been in new south wales. of these 361 notifications, 59 (16%) patients have had concurrent mycobacterial infection. seven of these patients had mycobacterium tuberculosis inf ... | 1988 | 3380039 |
| deep sepsis from mycobacterium tuberculosis after total hip replacement. case report. | one case of deep sepsis from mycobacterium tuberculosis occurring two years after total hip replacement is reported. the patient had no history of previous tuberculous infection nor showed any sign of systemic disease at the time of surgery. the clinical and pathogenic implications are discussed. | 1988 | 3382340 |
| [a case of congenital tuberculosis]. | a case of lethal acute congenital tuberculosis is reported in a 3-week-old infant who presented a crural adenopathy. an acute miliary pulmonary tuberculosis with extensive cutaneous reaction to tuberculin then appeared. mycobacterium tuberculosis was found in the node and in urines. specific treatment was ineffective and the child died within 5 weeks because of extensive lung lesions. a patent pulmonary tuberculosis was discovered in a grandmother that could not be incriminated to contamination ... | 1988 | 3387178 |
| tuberculous meningitis in children: a review of 15 cases. | tuberculosis meningitis (tbm) is the most serious form of infection with mycobacterium tuberculosis. between 1968 and 1986 15 children (five boys and 10 girls) were seen at the royal hospital for sick children, glasgow, because of tbm. fourteen children were caucasian and one was asian. the mean age at presentation was two years. none had been given bcg vaccination. in 12 children close contact with other cases of tuberculosis was reported. the signs and symptoms which helped in the diagnosis ar ... | 1988 | 3387999 |
| collagen fiber formation and proliferation as a mechanism of cancer prevention and regression induced by extract from mycobacterium tuberculosis: correlation between clinical observation and animal experiments. | administration of polysaccharides extracted from human mycobacterium tuberculosis bacilli, aoyama b strain (ssm) produced regression of breast cancer in 2 women. biopsies of tumor nodules from these patients revealed intense proliferation of collagen fibers from the stromal cells. ssm apparently promoted the proliferation and maturation of collagen fibers from the stromal cells and matrix destroyed by tumor infiltration. transplantation of human tumor cell lines into athymic mice resulted in the ... | 1988 | 3390842 |
| pharmacokinetic study of the interaction between rifampicin and ketoconazole. | this study assessed the potential pharmacokinetic interaction between rifampicin and ketoconazole, two drugs used to treat the increasingly common combination of mycobacterium tuberculosis and candida albicans infection in aids patients. the peak plasma rifampicin concentrations in six healthy male subjects were not altered when taken in conjunction with ketoconazole. however, the peak plasma ketoconazole levels were significantly diminished when taken in conjunction with rifampicin, compared to ... | 1988 | 3391862 |
| pulmonary complications of intravenous drug abuse. experience at an inner-city hospital. | fifty-one intravenous drug abusers were evaluated by a pulmonary consultative team over a 22-month period at a large inner city hospital. the most common pulmonary complication was septic pulmonary embolism, seen in 12 patients (23.5 percent). community-acquired pneumonia was diagnosed in ten patients (19.6 percent). mycobacterium tuberculosis occurred in five patients (9.8 percent). although 25 of 40 patients (63 percent) tested for human immunodeficiency virus antibody were positive, acquired ... | 1988 | 3396399 |
| anergy testing in nursing home residents. | delayed cutaneous hypersensitivity (dch) testing is commonly used to determine exposure to mycobacterium tuberculosis and in the evaluation of cellular-mediated immunity. many reports indicate that anergy to ubiquitous antigens is common in the elderly. recent studies suggest that anergy in the aged is not common when five or more antigens are used. because it is often difficult to purchase singularly or apply a larger number of quality dch antigens, we investigated the usefulness of the multite ... | 1988 | 3403878 |
| predictors of short-term prognosis in patients with pulmonary tuberculosis. | we evaluated 191 consecutive adults with pulmonary tuberculosis in order to develop methods to determine which patients should be initially hospitalized. using stepwise discriminant analysis, we found the six factors that were most strongly associated with an unfavorable short-term outcome (respiratory failure or death): lymphopenia, advanced age, concomitant smear-positive extrapulmonary tuberculosis, alcoholism, a high percentage of neutrophils on the differential white blood cell count, and l ... | 1988 | 3403993 |
| [peripheral lymph node tuberculosis in djibouti]. | 153 well documented records, gathered in one year in a tuberculosis center, were studied. adenoid localization represents on fourth of all tuberculosis, and 95% of all etiologies of peripheral adenopathies. value of bacteriological tests is studied and compared to the one of histology. the almost sole presence of mycobacterium tuberculosis hominis is an uncommon datum, interesting in the field of epidemiology. the recorded outstanding efficacy of modern anti-tuberculosis drugs is less known, per ... | 1988 | 3405070 |
| mycobacterium tuberculosis visceral abscesses in the acquired immunodeficiency syndrome (aids) | | 1988 | 3408063 |
| vegetarian diet and cobalamin deficiency: their association with tuberculosis. | to determine whether the high incidence of tuberculosis among asiatic indians in the united kingdom was due to impaired killing of mycobacterium tuberculosis by macrophages from patients deficient in cobalamin, a nutritional survey was carried out among 1187 indians and the incidence of tuberculosis determined from medical records. the question asked was whether tuberculosis was significantly more common among life-long vegetarians compared with omnivores. the incidence of tuberculosis in vegeta ... | 1988 | 3410971 |
| [cutaneous localizations of disseminated histoplasma capsulatum histoplasmosis in a case of acquired immunodeficiency]. | a widespread maculo-papular cutaneous rash appeared on a hiv-positive young bisexual cambodian man. he was treated for mycobacterium tuberculosis and pneumocystis carinii infections. he had been residing in france for seven years. histology showed, within the dermis, abundant extracellular and intramacrophagic yeast-like organisms suggestive of histoplasmosis. cultured specimens produced a growth of colonies after three weeks on sabouraud 4 p. 100 dextrose agar at 25 degrees c. numerous macrocon ... | 1988 | 3415148 |
| tuberculous synovitis with "rice bodies" presenting as carpal tunnel syndrome. | a 41-year-old man had typical symptoms and signs of carpal tunnel syndrome. at operation there were multiple large rice bodies along the flexor tendons with a great deal of adherent synovitis involving the index finger. widespread surgical debridement with excision of involved synovium was done. mycobacterium tuberculosis was cultured from the tenosynovium excised. | 1988 | 3418063 |
| pulmonary infection and cavity formation caused by mycobacterium tuberculosis in a child with aids. | | 1988 | 3419472 |
| secondary tuberculosis of the skin. clinical features and problems in laboratory diagnosis. | one hundred patients with secondary skin tuberculosis--59 with lupus vulgaris (lv), 27 with scrofuloderma (sd), and 14 with tuberculosis verrucosa cutis (tvc)-were included in this study. the buttocks and lower limbs were seen to be important sites of involvement in lv, besides the occurrence over the face. an active focus of tuberculosis was present in 18, a past history of pulmonary tuberculosis in 8, and intrafamilial tuberculous infections in 21. histopathology and culture for mycobacterium ... | 1987 | 3443525 |
| rationale for the histological spectrum of tuberculosis. a basis for classification. | there is need to re-appraise the cellular response to mycobacterium tuberculosis. histological analysis of 54 untreated patients with established disease demonstrated a continuous spectrum of tissue responses in which six groups correlated with evidence of resistance to bacterial multiplication. a predominance of cases in the two middle groups (82%) signified an immunological equilibrium in middle grade resistant patients that is absent in related diseases such as leprosy and cutaneous leishmani ... | 1987 | 3453999 |
| direct stimulation of monocyte release of interleukin 1 by mycobacterial protein antigens. | we examined stimulation of monocyte (mn) release of interleukin 1 (il 1) by soluble microbial products. mn from tuberculin skin test nonreactive donors incubated with ppd (100 micrograms/ml) released il 1 activity of 80.5 +/- 33.9 u/ml (mean +/- sd, n = 6), similar to that induced by optimal concentrations of lps (76.4 u/ml). okt3-reactive cells were not required for this process. ppd-stimulated il 1 release by mn did not appear to be due to endotoxin contamination, as 1) ppd contained 0.01% end ... | 1986 | 3484390 |
| role of nonspecific myelin destruction by delayed type hypersensitivity in primary demyelination. | to clarify the role of nonspecific myelin destruction mediated by delayed type hypersensitivity (dth) in primary demyelination, dth to tuberculin was induced within the endoneurium by intraneural injection of purified protein derivative (ppd) or sonicated mycobacterium tuberculosis into the sciatic nerves of lewis rats and guinea pigs which had previously been sensitized to tuberculin. the morphological features of the nerves proximal to the site of needle insertion were assessed 5 days after in ... | 1986 | 3487621 |
| antigen presentation by human antigen-presenting cells to antigen-specific xenogeneic murine t cells. | successful antigen presentation by xenogeneic human antigen-presenting cells (apc) to stimulate the proliferation of antigen-specific, keyhole limpet hemocyanin (klh)-specific, ovalbumin (ova)-specific, and purified protein derivative of mycobacterium tuberculosis (ppd)-specific murine t cells was observed. evidence indicating a direct cell interaction between antigen-specific murine t cells and xenogeneic human apc was given by experiments using antigen-specific murine t cell clones. the ova-sp ... | 1986 | 3487694 |
| pulmonary manifestations of aids: review of 106 episodes. | we reviewed the clinical records and chest radiographs of all patients admitted to our institution between 1982 and 1984 who had pulmonary disease and who were later proved to have acquired immunodeficiency syndrome (aids) (95 patients). diffuse parenchymal lung disease was the most common finding. these infiltrates were usually interstitial and caused by pneumocystis carinii pneumonia or p. carinii combined with cytomegalovirus infection. focal, multilobar, interstitial infiltrates were also of ... | 1986 | 3489955 |
| skin test responsiveness to four new tuberculins in patients with chronic obstructive airways disease receiving short term high doses of, or long term maintenance treatment with, prednisolone: clinical appearances and histometric studies. | the response to skin testing with tuberculins extracted from various species of mycobacteria was studied in 49 patients from dundee with chronic obstructive airways disease. seventeen had never been treated with steroids (group 1), 17 were receiving short term high doses of prednisolone (group 2) and did not have impaired synacthen tests; 15 were receiving long term maintenance treatment and did have impaired synacthen tests (group 3). erythematous and indurated reactions were seen in a few pati ... | 1987 | 3493262 |
| [a new method of applying a tuberculin ointment for cutaneous use compared to the mantoux test]. | the method for the applications of tuberculin ointment for the skin test by means of special aluminum chambers (finn chambers, obtained from epitest ltd. oy, finland) was approved after trial. for control, the mantoux test (intracutaneous tuberculin test) was used. the results of these two tests, made in parallel, were found to coincide in children with clinical symptoms of tuberculosis, or infected with mycobacterium tuberculosis, in 84% of cases. the tuberculin skin test with the use of finn c ... | 1987 | 3494363 |
| aging and immunity to tuberculosis: increased susceptibility of old mice reflects a decreased capacity to generate mediator t lymphocytes. | this study employed an experimental mouse model of mycobacterium tuberculosis infection to investigate the effects of aging on t cell-mediated protective cellular immunity. it was found that although mice of 3 to 18 mo of age were fully resistant to a standard immunizing dose of mycobacterium tuberculosis, progressive mortality was observed in old (24 to 28 mo) mice. death of these older animals was associated with an inability to contain or to eliminate the mycobacterial infection in the spleen ... | 1987 | 3495592 |
| properties of proteins mpb64, mpb70, and mpb80 of mycobacterium bovis bcg. | the immunogenic proteins mpb64 and mpb80 of mycobacterium bovis bcg were purified to homogeneity and compared with mpb70. mpb70 and mpb80 showed a similar distribution in substrains of bcg, both being present in high concentrations in culture fluids of bcg substrain tokyo, bcg moreau, bcg russia, and bcg sweden and in only very small amounts in bcg glaxo, bcg tice, bcg copenhagen, and bcg pasteur. in various physicochemical properties mpb70 and mpb80 were closely similar, but mpb80 had a distinc ... | 1986 | 3514457 |
| bovine variants of mycobacterium tuberculosis isolated in liverpool during the period 1969 to 1983: an epidemiological survey. | between 1969 and 1983 inclusive, the bovine variants of mycobacterium tuberculosis (m. bovis and m. africanum) were isolated from 75 patients with tuberculosis. this represented 2.9 per cent of all significant mycobacteria identified at the liverpool public health laboratory during this period. the clinical and radiological features of infection did not differ from those found with m. tuberculosis. there was an association between m. bovis infection, extrapulmonary disease and lifelong united ki ... | 1986 | 3529160 |
| elective orotracheal intubation and aspiration for microbiologic diagnosis in children. | endotracheal intubation is generally performed to facilitate the treatment of respiratory failure or to control the airway during general anesthesia. we electively intubated 14 children with undiagnosed pneumonia to obtain tracheobronchial secretions for microbiologic diagnosis. three were intubated awake, three with sedation, and eight with sedation and neuromuscular blockade. mycobacterium tuberculosis was isolated in four of six patients suspected of having tuberculosis. other bacterial patho ... | 1986 | 3530638 |
| clinical significance of nontuberculous mycobacteria. a bacteriological survey of swedish strains isolated between 1973 and 1981. | an account is rendered of mycobacteria other than mycobacterium tuberculosis isolated from specimens sent for culture during 9 years. the possible etiological significance of these bacteria was estimated from clinical data and the degree of bacterial growth. pulmonary infection was the most common nontuberculous manifestation in the adults. in about 50% of the patients with slowly growing mycobacteria in their respiratory tract, these bacteria were considered to be an etiological factor. this ap ... | 1986 | 3532304 |
| human pulmonary infections with bovine and atypical mycobacteria in lagos, nigeria. | a total of 2784 cases with persistent symptoms of lower respiratory tract infections were seen in four of the chest clinics in lagos between january and june of 1983. of these, 668 were randomly selected and screened for pulmonary tuberculosis. repeated sputum samples from the 668 patients were cultured on lowenstein-jenseen slopes and 102 pure mycobacterial isolates were obtained. the isolates were differentiated into tubercle bacilli, bovine or atypical mycobacteria on the basis of results obt ... | 1986 | 3534283 |
| [comparative characteristics of the activity of proteolytic enzymes and their inhibitors in the lung tissue of guinea pigs during development of generalized and destructive tuberculosis]. | two series of experiments were carried out using 66 guinea pigs infected with tuberculosis. in the first experiment generalized tuberculosis was stimulated by means of subcutaneous administration of mycobacterium tuberculosis h37rv strain at a dose of 0.0001 mg. in the second experiment destructive form of tuberculosis was developed after intrapulmonary administration of the bacteria (1 mg) followed by vcg vaccination. in both experiments the animals were divided into groups with spontaneous for ... | 1986 | 3535249 |
| [abdominal lymph node tuberculosis: diagnostic value of echography and x-ray computed tomography]. | the aspects of abdominal ultrasonography and computed tomography (ct) were studied in 4 patients (3 african and 1 haitian) with abdominal tuberculosis. all were markedly debilitated and three patients had protracted fever. tuberculosis was documented in all cases by demonstrating mycobacterium tuberculosis in cultures of lymph nodes taken during laparotomy and/or cultures of products of gastric aspiration. ultrasonography showed enlarged lymph nodes in the pancreatic and peripancreatic areas and ... | 1986 | 3539689 |
| immunological detection of hcg-like substances in aerobic bacteria of both tumour and non-tumour origin. | production of hormone-like substances by prokaryotes and unicellular eukaryotes, as well as the presence of a human chorionic gonadotropin-like substance in the serum of individuals with malignancies, have been previously established. to determine the presence and distribution of the production of human chorionic gonadotropin (hcg) among aerobic bacteria, fourteen strains of bacteria of both tumour and non-tumour origin were examined using enzyme-linked immunosorbent assay (elisa), immunofluores ... | 1986 | 3540534 |
| identification of specific and cross-reactive antigens of leishmania donovani chagasi by human infection sera. | cloned leishmania donovani chagasi (ldc) promastigotes were analyzed by sds-page separation and immunoblotting with human infection sera. the patterns of antigen reactivity were compared by using sera from individuals with ldc, leishmania mexicana amazonensis (lma), trypanosoma cruzi, mycobacterium tuberculosis, or mycobacterium leprae infections. sera from individuals with these infections recognized ldc antigens in several m.w. ranges. reactivity was due to recognition of ldc molecules and not ... | 1987 | 3543131 |
| antibacterial activity and mechanism of action of 3'-azido-3'-deoxythymidine (bw a509u). | the thymidine analog 3'-azido-3'-deoxythymidine (bw a509u; azidothymidine [azt]) had potent bactericidal activity against many members of the family enterobacteriaceae, including strains of escherichia coli, salmonella typhimurium, klebsiella pneumoniae, shigella flexneri, and enterobacter aerogenes. azt also had bactericidal activity against vibrio cholerae and the fish pathogen vibrio anguillarum. azt had no activity against pseudomonas aeruginosa, gram-positive bacteria, anaerobic bacteria, m ... | 1987 | 3551832 |
| childhood lymphadenitis in a harsh northern climate due to atypical mycobacteria. | between 1979 and 1983, 16 patients under 15 years of age living within 480 km of edmonton, alberta (latitude 53 degrees 34' n) were seen with cervical lymphadenitis caused by atypical mycobacteria. during this period only 4 cases of cervical lymphadenitis from mycobacterium tuberculosis occurred in the same age and geographical grouping. young children age 1-4 years accounted for most cases (14/16). the onset showed no seasonal preponderance and the nodal enlargement was either asymptomatic (8/1 ... | 1987 | 3563428 |
| clinical features of pulmonary tuberculosis in young and old veterans. | pulmonary tuberculosis (tb) continues to pose a health threat to the elderly population. in order to delineate age-related differences in disease presentation a comparison between young and old male veterans hospitalized over a five-year period with culture proven mycobacterium tuberculosis is reported. the study sample included 27 patients 60 years of age and older (range, 60 to 85; mean, 70) and 52 patients under 60 years of age (range, 22 to 59; mean, 51). the elderly were significantly less ... | 1987 | 3571803 |
| bone growth and haemopoiesis: steroid reversible anaemia, myelofibrosis and increased bone formation in a child. | factors regulating the interaction between bone marrow haemopoietic cells, stromal elements and bone growth are poorly understood. disturbance in the equilibrium between these elements can occur as the result of metabolic bone disease, haematologic disorders, neoplasia and infections. the present report concerns a child with myelofibrosis, hypoplastic/dyserythropoietic anaemia, osteoblast proliferation and increased bone formation. a positive tuberculin skin test and elevated eb virus titre indi ... | 1987 | 3593656 |
| diagnosis of pulmonary tuberculosis by detection of tuberculostearic acid in sputum by using gas chromatography-mass spectrometry with selected ion monitoring. | tuberculostearic acid [(r)-10-methyloctadecanoic acid (tbsa)] is a structural component of mycobacteria, and its detection in appropriate clinical specimens has potential application as a rapid screening method for the presence of mycobacterium tuberculosis and other mycobacteria. we used the highly sensitive technique of gas chromatography-mass spectrometry (gc-ms) combined with selected ion monitoring (sim) of m/e 312 and m/e 167 for detecting tbsa in 405 clinical sputum specimens collected in ... | 1987 | 3598233 |
| acquired immune deficiency syndrome (aids) in brazil. necropsy findings. | according to the 15 autopsies performed at the department of pathological anatomy, escola paulista de medicina, são paulo, brazil, it was confirmed that acquired immunodeficiency syndrome (aids) occurs preferably in young homosexual males, who die in a short period of time of the disease, which leads to a consumptive state verified by cachexia of the cadavers. the most affected organs of this series were the lungs and encephalum, exactly the ones responsible for the immediate cause of death. in ... | 1987 | 3620018 |
| rapid identification using a specific dna probe of mycobacterium avium complex from patients with acquired immunodeficiency syndrome. | specific dna probes (gen-probe corp., san diego, calif.) for mycobacterium avium, mycobacterium intracellulare, and mycobacterium tuberculosis were compared with conventional methods for the identification of isolates of the mycobacterium avium complex. a total of 56 isolates of m. avium complex were recovered from 34 respiratory, 13 blood, 6 stool, and 3 urine samples from 23 patients. a total of 33 isolates were tested directly from middlebrook 7h11 agar plates, and 23 isolates were tested dir ... | 1987 | 3624446 |
| tuberculosis in patients with the acquired immunodeficiency syndrome. clinical features, response to therapy, and survival. | tuberculosis has been reported previously in patients with acquired immunodeficiency syndrome who are at increased risk of prior infection with mycobacterium tuberculosis. we performed a population-based study of aids and tuberculosis in san francisco using the tuberculosis and aids registries of the san francisco department of public health. of 287 cases of tuberculosis in non-asian-born males 15 to 60 yr of age reported from 1981 through 1985, 35 (12%) also had aids, including 23 american-born ... | 1987 | 3631730 |
| [analysis of the annual volumes from 1950-1959 and 1970-1979 of the "zentralblatt für gynäkologie" with reference to changes in pathogens]. | in order to analyse the germ change there have been analysed by way of comparison original articles from the "zentralblatt für gynäkologie" of the periods from 1950 to 1959 and 1970 to 1979. in the period from 1970 to 1979 the frequency of demonstrated anaerobic germs increased (12fold), of gram-negative germs as well (from 28% to 32%); in particular that applies to representatives of enterobacteriaceae (especially e. coli). on the other hand the frequency of the demonstrated mycobacterium tuber ... | 1986 | 3644584 |
| mycobacterium tuberculosis infection in the acquired immunodeficiency syndrome. a review of 14 patients. | the clinical findings in 13 drug abusers and one homosexual man with tuberculosis and the acquired immunodeficiency syndrome (aids) from new york city are described. tuberculosis preceded the diagnosis of aids in nine of the 14 patients by a mean of 7 months and occurred within the same month in the remaining five. the presence of thrush, generalised lymphadenopathy, lymphopenia, cutaneous anergy and chest radiographs showing hilar adenopathy and/or lower lobe infiltrates was common among the pa ... | 1986 | 3660457 |
| occupational exposure to mycobacterium tuberculosis and cytology of response to skin testing with 'new tuberculin'. | | 1987 | 3660464 |
| the method of preparation of an antigen may influence the cellular reaction to it in skin tests for delayed hypersensitivity: comparison between responses to two different reagents prepared from mycobacterium tuberculosis. | antigen preparations extracted from mycobacterium tuberculosis by different procedures--ppd and 'new tuberculin'--were compared with respect to the cytology of the type iv reaction they elicit in the dermis. the numbers and microanatomical localization of cells of the major lymphocyte and monocyte subsets were measured histometrically in immunocytochemically-stained sections of biopsies of the 48 h reactions. despite the close similarity in size of the external appearance of the reactions provok ... | 1987 | 3665186 |
| mycobacterium tuberculosis hominis infection and aids. | | 1987 | 3667199 |
| [septicemia due to tuberculosis in hiv infection]. | a 27-year old female hiv-positive patient developed septic tuberculosis, with mycobacterium tuberculosis typus humanus repeatedly found not only in sputum, bronchial secretion, blood and faeces but also in biopsy material from the liver. although standard therapy with pyrazinamid, rifampicin and inh had to be replaced at times by ethambutol or streptomycin respectively, there was a surprisingly fast clinical and bacteriological improvement. establishment of the diagnosis aids requires not only h ... | 1987 | 3672072 |
| [atypical mycobacterioses. unusual pathogens of increasing significance]. | atypical mycobacteria may cause pulmonary diseases - similar to tuberculosis - as well as infections of the lymph nodes, the skin and other organs. but only if several cultures from sputum or biopsy specimen have been positive and mycobacterium tuberculosis has been excluded, these species can be noted as the pathogenetic agents. the course of disease mostly times appears uncharacteristic, the manifestations remind of chronic tuberculosis. the majority of patients with atypical mycobacterioses b ... | 1987 | 3673095 |
| [diagnostic bronchoscopy--mycologic and bacteriologic findings]. | the authors studied the findings of mycotic and bacterial agents in the lower air passages of 122 patients with lung disease examined by bronchoscopy. the series represents a current profile of patients investigated at the department of tuberculosis and respiratory diseases, pardubice hospital within 17 months of the years 1982-1983. bronchial swabs were compared with the findings in the swabs of the throat taken immediately before the endoscopic examination. yeast organisms were isolated from t ... | 1987 | 3673125 |
| [multifocal tuberculosis in a 15-year-old child]. | we report the case of a 15 year-old boy, presenting with juxta-articular swellings and lacunar skeletal lesions associated with prolonged fever and cachexia. among the multiple bacteriological samplings, only the trans-osseous puncture of a tibial lacunar lesions, yielded bacillus tuberculosis. with triple anti-tuberculous chemotherapy, fever and juxta-articular swellings disappeared. however, several articular ankyloses persist, which might need a surgical correction. | 1986 | 3707278 |
| effects of protein deprivation and bcg vaccination on alveolar macrophage function in pulmonary tuberculosis. | alveolar macrophages were isolated from lung lavage fluids taken from bcg-vaccinated and nonvaccinated guinea pigs 2 and 4 wk after challenge with virulent mycobacterium tuberculosis h37rv by the respiratory route. animals had been maintained on either purified, protein-adequate (30%) or protein-deficient (10%) isocaloric diets for 6 wk prior to respiratory challenge. protein deficiency was accompanied by loss of dermal tuberculin reactivity, even in animals with extensive tuberculosis. vaccinat ... | 1986 | 3717761 |
| cutaneous lesion caused by mycobacterium tuberculosis in a dog. | a 5-month-old female mixed-breed dog was examined because of nonhealing wounds in the right submandibular region. treatment with antibiotics and surgical excision was ineffective. specimens of the right mandibular lymph node and surrounding tissues were submitted for bacteriologic culturing, and mycobacterium tuberculosis was isolated. the dog was euthanatized. the risk of infection of human beings who associate with dogs that have cutaneous wounds caused by mycobacteria is unknown. | 1986 | 3721971 |