| community-acquired pyelonephritis in pregnancy caused by kpc-producing klebsiella pneumoniae. | carbapenem-resistant enterobacteriaceae (cre) usually infect patients with significant comorbidities and health care exposures. we present a case of a pregnant woman who developed community-acquired pyelonephritis caused by kpc-producing klebsiella pneumoniae. despite antibiotic treatment, she experienced spontaneous prolonged rupture of membranes, with eventual delivery of a healthy infant. this report demonstrates the challenge that cre may pose to the effective treatment of common infections ... | 2015 | 26185273 |
| determining the resistance of carbapenem-resistant klebsiella pneumoniae to common disinfectants and elucidating the underlying resistance mechanisms. | carbapenem-resistant klebsiella pneumoniae (crkp) infection is a serious problem in hospitals worldwide, posing a particular risk to immunocompromised patients. elimination strategies may prevent these drug-resistant bacteria from spreading within hospital environments. here, the susceptibility of patient-derived crkp strains to common chemical disinfectants and possible correlations between the presence of drug-resistance genes and increased resistance to disinfectants were investigated. | 2015 | 26184804 |
| laparoscopic drainage of abdominal wall abscess from spilled stones post-cholecystectomy. | we present a case on abdominal wall abscess from spilled stones post-cholecystectomy and describe laparoscopic drainage as our choice of management. mr m is a 75-year-old male who presented on multiple occasions to the hospital with right upper quadrant pain and fever post-laparoscopic cholecystectomy. he also required multiple courses of antibiotics. subsequent computed tomography and magnetic resonance imaging scan confirmed a number of retained stone with signs of chronic inflammation. hence, ... | 2015 | 26183574 |
| the role of platelet myd88 in host response during gram-negative sepsis. | beside their role in hemostasis, platelets serve as sentinel cells in host defense during infection. in sepsis, platelets have been implicated in both beneficial (antibacterial) and detrimental responses (thrombosis and organ damage). toll-like receptors and their common adaptor, myeloid differentiation factor 88 (myd88), are essential for pathogen recognition and protective immunity. platelets express functional toll-like receptors and myd88, which participate in platelet responsiveness to bact ... | 2015 | 26178922 |
| managing a nosocomial outbreak of carbapenem-resistant klebsiella pneumoniae: an early australian hospital experience. | carbapenems are traditionally reserved as the last line of defence for treatment of serious infections with multiresistant gram-negative bacilli. reports of klebsiella pneumoniae carbapenemase (kpc)-producing organisms have been emerging globally, but rare in australasia to date. we describe an outbreak of kpc-2 producing k. pneumoniae at an australian hospital. | 2015 | 26178306 |
| an update of the evolving epidemic of blakpc carrying klebsiella pneumoniae in sicily, italy, 2014: emergence of multiple non-st258 clones. | in italy, klebsiella pneumoniae carbapenemase producing k. pneumoniae (kpc-kp) strains are highly endemic and kpc producing cc258 is reported as the widely predominating clone. in palermo, italy, previous reports have confirmed this pattern. however, recent preliminary findings suggest that an epidemiological change is likely ongoing towards a polyclonal kpc-kp spread. here we present the results of molecular typing of 94 carbapenem non susceptible k. pneumoniae isolates detected during 2014 in ... | 2015 | 26177547 |
| deletion of the budbac operon in klebsiella pneumoniae to understand the physiological role of 2,3-butanediol biosynthesis. | klebsiella pneumoniae is known to produce 2,3-butanediol (2,3-bdo), a valuable chemical. in k. pneumoniae, the 2,3-bdo operon (budbac) is involved in the production of 2,3-bdo. to observe the physiological role of the 2,3-bdo operon in a mixed acid fermentation, we constructed a budbac-deleted strain (sgsb109). the production of extracellular metabolites, co2 emission, carbon distribution, and nadh/nad(+) balance of sgsb109 were compared with the parent strain (sgsb100). when comparing the carbo ... | 2016 | 26176425 |
| potential virulence of klebsiella sp. isolates from enteral diets. | we aimed to evaluate the potential virulence of klebsiella isolates from enteral diets in hospitals, to support nosocomial infection control measures, especially among critical-care patients. phenotypic determination of virulence factors, such as capsular expression on the external membrane, production of aerobactin siderophore, synthesis of capsular polysaccharide, hemolytic and phospholipase activity, and resistance to antibiotics, which are used therapeutically, were investigated in strains o ... | 2015 | 26176307 |
| prolonged delay for controlling kpc-2-producing klebsiella pneumoniae outbreak: the role of clinical management. | carbapenemase-producing enterobacteriaceae (cpe) are becoming of immediate concern for infection control policies. prompt detection of cpe on health care setting admission is crucial to halt the spread of an outbreak. we report a cluster of 13 klebsiella pneumoniae carbapenemase (kpc)-2-producing k pneumoniae cases in a tertiary care hospital.the objective of this study was to identify contributing factors originating the outbreak. | 2015 | 26174583 |
| the human il-22 receptor is regulated through the action of the novel e3 ligase subunit fbxw12, which functions as an epithelial growth suppressor. | interleukin- (il-) 22 signaling is protective in animal models of pneumonia and bacteremia by klebsiella pneumoniae and mediates tissue recovery from influenza and staph aureus infection. we recently described processing of mouse lung epithelial il-22 receptor (il-22r) by ubiquitination on the intracellular c-terminal. to identify cellular factors that regulate human il-22r, we screened receptor abundance while overexpressing constituents of the ubiquitin system and identify that il-22r can be s ... | 2015 | 26171402 |
| infections caused by kpc-producing klebsiella pneumoniae: differences in therapy and mortality in a multicentre study--authors' response. | | 2015 | 26169556 |
| mapping the resistance-associated mobilome of a carbapenem-resistant klebsiella pneumoniae strain reveals insights into factors shaping these regions and facilitates generation of a 'resistance-disarmed' model organism. | this study aims to investigate the landscape of the mobile genome, with a focus on antibiotic resistance-associated factors in carbapenem-resistant klebsiella pneumoniae. | 2015 | 26169555 |
| effects of klebsiella pneumoniae carbapenemase subtypes, extended-spectrum β-lactamases, and porin mutations on the in vitro activity of ceftazidime-avibactam against carbapenem-resistant k. pneumoniae. | avibactam is a novel β-lactamase inhibitor with affinity for klebsiella pneumoniae carbapenemases (kpcs). in combination with ceftazidime, the agent demonstrates activity against kpc-producing k. pneumoniae (kpc-kp). kpc-kp strains are genetically diverse and harbor multiple resistance determinants, including defects in outer membrane proteins and extended-spectrum β-lactamases (esbls). mutations in porin gene ompk36 confer high-level carbapenem resistance to kpc-kp strains. whether specific mec ... | 2015 | 26169413 |
| inhibition of aminoglycoside 6'-n-acetyltransferase type ib-mediated amikacin resistance in klebsiella pneumoniae by zinc and copper pyrithione. | the in vitro activity of the aminoglycoside 6'-n-acetyltransferase type ib [aac(6')-ib] was inhibited by cucl2 with a 50% inhibitory concentration (ic50) of 2.8 μm. the growth of an amikacin-resistant klebsiella pneumoniae strain isolated from a neonate with meningitis was inhibited when amikacin was supplemented by the addition of zn(2+) or cu(2+) in complex with the ionophore pyrithione. coordination complexes between cations and ionophores could be developed for their use, in combination with ... | 2015 | 26169410 |
| carbapenemase-producing klebsiella pneumoniae, a key pathogen set for global nosocomial dominance. | the management of infections due to klebsiella pneumoniae has been complicated by the emergence of antimicrobial resistance, especially to carbapenems. resistance to carbapenems in k. pneumoniae involves multiple mechanisms, including the production of carbapenemases (e.g., kpc, ndm, vim, oxa-48-like), as well as alterations in outer membrane permeability mediated by the loss of porins and the upregulation of efflux systems. the latter two mechanisms are often combined with high levels of other ... | 2015 | 26169401 |
| tracking a hospital outbreak of kpc-producing st11 klebsiella pneumoniae with whole genome sequencing. | an outbreak of carbapenem-resistant klebsiella pneumoniae strains emerged at a hospital, and was tracked in order to understand the spread of these infectious pathogens. a total of 66 k. pneumoniae strains were collected from sterile samples in 2012. the mics of 20 antimicrobial agents were determined for all strains. molecular typing was performed with pulsed-field gel electrophoresis (pfge). twelve blakpc-producing k. pneumoniae strains isolated from ten patients were selected for whole genome ... | 2015 | 26166545 |
| surveillance of carbapenem non-susceptible gram negative strains and characterization of carbapenemases of classes a, b and d in a lebanese hospital. | the production of carbapenem-hydrolyzing enzymes has been recognized as one of the most currently relevant resistance mechanisms in gram negative bacterial isolates, and is being detected in various countries. in lebanon, carbapenem resistance was studied among gram negative pathogens collected from a university hospital from january to june of years 2011 and 2012. all isolates were subjected to phenotypic tests including antibiotic susceptibility, cloxacillin effect, modified hodge test, and et ... | 2015 | 26164974 |
| natural anti-infective pulmonary proteins: in vivo cooperative action of surfactant protein sp-a and the lung antimicrobial peptide sp-bn. | the anionic antimicrobial peptide sp-b(n), derived from the n-terminal saposin-like domain of the surfactant protein (sp)-b proprotein, and sp-a are lung anti-infective proteins. sp-a-deficient mice are more susceptible than wild-type mice to lung infections, and bacterial killing is enhanced in transgenic mice overexpressing sp-b(n). despite their potential anti-infective action, in vitro studies indicate that several microorganisms are resistant to sp-a and sp-b(n). in this study, we test the ... | 2015 | 26163587 |
| prevalence of and risk factors for endogenous endophthalmitis in patients with pyogenic liver abscesses. | although pyogenic liver abscesses (plas) can be successfully treated, the visual prognosis of patients with endogenous endophthalmitis (ee) associated with a pla is poor. early diagnosis and prompt intervention may salvage useful vision. therefore, we investigated risk factors for ee in patients with pla, to facilitate early diagnosis. | 2015 | 26161011 |
| complete genome sequence of a ctx-m-15-producing klebsiella pneumoniae outbreak strain from multilocus sequence type 514. | we report here the genome sequence of a multidrug-resistant klebsiella pneumoniae strain, which caused an outbreak in a neonatal ward in 2011. the genome consists of a single chromosome (5,278 kb) and three plasmids (362 kb, 5 kb, and 4 kb). | 2015 | 26159529 |
| coincidental detection of the first outbreak of carbapenemase-producing klebsiella pneumoniae colonisation in a primary care hospital, finland, 2013. | in finland, occurrence of klebsiella pneumoniae carbapenemase-producing k. pneumoniae (kpc-kp) has previously been sporadic and related to travel. we describe the first outbreak of colonisation with kpc-kp strain st512; it affected nine patients in a 137-bed primary care hospital. the index case was detected by chance when a non-prescribed urine culture was taken from an asymptomatic patient with suprapubic urinary catheter in june 2013. thereafter, all patients on the 38-bed ward were screened ... | 2015 | 26159309 |
| a high burden of late-onset sepsis among newborns admitted to the largest neonatal unit in central vietnam. | the objective of this study is to determine the prevalence, causes and outcome of sepsis in hospitalized neonates in the largest neonatal unit in central vietnam. | 2015 | 26156065 |
| antibiotic resistance as a major public health concern: epidemiology and economic impact. | antimicrobial resistance (amr) is mainly sustained by the improper use of antibiotics and has become a global public health concern both in the field of human and animal health. italy has the highest prevalence of amr among european countries, in particular carbapenem-resistant klebsiella pneumoniae, which reached 34.3% in 2013. multidrug-resistant microorganisms' infections are associated with increased risk of complications, higher hospitalization rates, increased healthcare costs, loss of pro ... | 2015 | 26152543 |
| outbreak of colonization by carbapenemase-producing klebsiella pneumoniae in a neonatal intensive care unit: investigation, control measures and assessment. | we describe an outbreak of carbapenemase-producing klebsiella pneumoniae in a neonatal intensive care unit and assess the effect of infection control measures. our assessment indicates that active surveillance culture is very useful in identifying multidrug-resistant organisms and its prevention from transmission. besides contact precaution, environment disinfection, good compliance of hand hygiene, and single-room isolation is very important for preventing transmission of carbapenemase-producin ... | 2015 | 26149749 |
| ceftolozane/tazobactam and ceftazidime/avibactam: two novel β-lactam/β-lactamase inhibitor combination agents for the treatment of resistant gram-negative bacterial infections. | the rise in resistant gram-negative bacteria is a major concern and has led to difficulty in treating multidrug-resistant (mdr) infections. two recently approved combination antibiotics, ceftolozane/tazobactam and ceftazidime/avibactam, may be effective in treating these resistant infections. ceftolozane is a novel cephalosporin that has been developed in combination with tazobactam, a recognised β-lactamase inhibitor (bli). avibactam is a novel bli combined with ceftazidime, a cephalosporin wit ... | 2015 | 26143591 |
| clinical and molecular characteristics of multi-clone carbapenem-resistant hypervirulent (hypermucoviscous) klebsiella pneumoniae isolates in a tertiary hospital in beijing, china. | to provide the clinical and molecular characteristics of carbapenem-resistant hypervirulent (hypermucoviscous) klebsiella pneumoniae (cr-hvkp) in a tertiary hospital in beijing, china. | 2015 | 26141415 |
| unusual complication of multiple splenic abscesses arising from a feeding jejunostomy tube subsequent to total gastrectomy: a case report and literature review. | splenic abscess is a rare clinical entity. the present study reports a case of a patient that suffered from splenic abscess secondary to septicemia resulting from klebsiella pneumoniae infection following the removal of the feeding jejunostomy tube that was utilized subsequent to the patient undergoing total gastrectomy as part of the treatment regimen for gastric adenocarcinoma. the early clinical presentation was nonspecific and multiple splenic abscesses were subsequently identified. to reduc ... | 2015 | 26137078 |
| risk factors and outcomes of carbapenem-resistant klebsiella pneumoniae infections in liver transplant recipients. | carbapenem-resistant klebsiella pneumoniae (crkp) infection is increasing in incidence and is associated with increased mortality in liver transplantation (lt) recipients. we performed a retrospective cohort study of all patients transplanted between january 2010 and january 2013 to identify the incidence and risk factors for post-lt crkp infection and evaluate the impact of this infection on outcomes in a crkp-endemic area. we studied 304 recipients, of whom 20 (6.6%) developed crkp and 36 (11. ... | 2015 | 26136397 |
| extended-spectrum β-lactamase (esbl)-producing klebsiella pneumoniae in bulk tank milk from dairy farms in indonesia. | bulk tank milk from 80 dairy farms located in the west java region of indonesia was analyzed for the presence of extended-spectrum β-lactamase (esbl)-producing enterobacteriaceae. isolates from seven dairy farms were esbl positive, and all were identified as klebsiella pneumoniae. the isolates showed esbl-characteristic antibiotic resistance patterns. further analysis revealed that all k. pneumoniae isolates harbored the blashv gene, and two isolates were additionally positive for the blatem-1 a ... | 2015 | 26135892 |
| tracking nosocomial klebsiella pneumoniae infections and outbreaks by whole-genome analysis: small-scale italian scenario within a single hospital. | multidrug-resistant (mdr) klebsiella pneumoniae is one of the most important causes of nosocomial infections worldwide. after the spread of strains resistant to beta-lactams at the end of the previous century, the diffusion of isolates resistant to carbapenems and colistin is now reducing treatment options and the containment of infections. carbapenem-resistant k. pneumoniae strains have spread rapidly among italian hospitals, with four subclades of pandemic clonal group 258 (cg258). here we sho ... | 2015 | 26135860 |
| potency of both human th1 and nk helper cell activation is determined by il-12p70-producing pamp-matured dcs. | besides t helper (th) cells, natural killer (nk) cells have also been described to participate in the shaping of dendritic cell (dc)-mediated adaptive immune responses. at present, it remains unclear to what extent the induction of these nk helper cell immune mechanisms is coupled with th responses and whether both helper immune responses are induced by the same dc upon specific pathogen recognition receptor (prr) stimulation. in this study, we demonstrate that maturation of dcs with a cocktail ... | 2015 | 26134473 |
| monocyclic β-lactam and unexpected oxazinone formation: synthesis, crystal structure, docking studies and antibacterial evaluation. | novel monocyclic β-lactam derivatives bearing aryl, phenyl and heterocyclic rings were synthesized as possible antibacterial agents. cyclization of imines (3h, 3t) with phenylacetic acid in the presence of phosphoryl chloride and triethyl amine did not afford the expected β-lactams. instead, highly substituted 1,3-oxazin-4-ones (4h, 4t) were isolated as the only product and confirmed by single crystal x-ray analysis of 4t. the results of antibacterial activity showed that compound 4l exhibited c ... | 2016 | 26133357 |
| induction and nosocomial dissemination of carbapenem and polymyxin-resistant klebsiella pneumoniae. | polymyxins are antimicrobial agents capable of controlling carbapenemase-producing klebsiella pneumoniae infection. | 2015 | 26132495 |
| urine nested polymerase chain reaction in neonatal septicemia. | this cross-sectional study was done to evaluate diagnostic efficacy of urine nested polymerase chain reaction (pcr) using broad-range 16srdna pcr-based amplification, followed by restriction analysis and sequencing in neonatal septicemia. the study included 50 babies; 48% had vaginal delivery, 46% were preterm, 20% had a history of prolonged rupture of membranes and 56% were low birth weight (≤2500 g). clinical presentations were lethargy (96%), respiratory distress (80%) and bleeding diathesis ... | 2015 | 26130622 |
| prevalence of klebsiella pneumoniae strains producing carbapenemases and increase of resistance to colistin in an italian teaching hospital from january 2012 to december 2014. | the aim of this study was to characterize the spread of carbapenemase-producing klebsiella pneumoniae (cpkp) in a tertiary level hospital using ongoing active surveillance with rectal swab cultures. furthermore, this study analyzed the presence of cpkp in the clinical samples (cs) of a single patient as well as the evolution of colistin-sensitive strains (cos) to colistin-resistant strains (cor). | 2015 | 26116560 |
| diffusion and transmission of carbapenem-resistant klebsiella pneumoniae in the medical and surgical wards of a university hospital in milan, italy. | carbapenem-resistant klebsiella pneumoniae (crkp) is emerging as a public health problem worldwide. in italy, a remarkable increase in crkp cases has been reported since 2010. in this study, crkp diffusion, distribution and in-hospital transmission trends were evaluated in a university hospital in milan, italy, from january 2012 to december 2013. isolates from 63 newly detected crkp-positive patients were genotyped, and possible transmission was determined by combining the molecular results with ... | 2016 | 26116453 |
| industrial production of 2,3-butanediol from the engineered corynebacterium glutamicum. | the platform chemical 2,3-butanediol (2,3-bdo) is a valuable product that can be converted into several petroleum-based chemicals via simple chemical reactions. here, we produced 2,3-bdo with the non-pathogenic and rapidly growing corynebacterium glutamicum. to enhance the 2,3-bdo production capacity of c. glutamicum, we introduced buda encoding acetolactate decarboxylase from klebsiella pneumoniae, a powerful 2,3-bdo producer. additionally, budb (encoding α-acetolactate synthase) and budc (enco ... | 2015 | 26113219 |
| dissemination of clonally related multidrug-resistant klebsiella pneumoniae in ireland. | in october 2012, an outbreak of gentamicin-resistant, ciprofloxacin non-susceptible extended-spectrum β-lactamase (esbl)-producing klebsiella pneumoniae occurred in a neonatal intensive care unit in ireland. in order to determine whether the outbreak strain was more widely dispersed in the country, 137 isolates of k. pneumoniae with this resistance phenotype collected from 17 hospitals throughout ireland between january 2011 and july 2013 were examined. esbl production was confirmed phenotypical ... | 2016 | 26113052 |
| successful treatment of lower urinary tract infections with oral fosfomycin: a report of three cases. | infections due to multidrug-resistant organisms continue to increase, and therapeutic options remain scarce. given this challenge, it has become necessary to use older antimicrobials for treatment of these pathogens. we report three patients with lower urinary tract infections caused by klebsiella pneumoniae carbapenemase (kpc)-producing klebsiella pneumoniae who were successfully treated with a seven-day course of oral fosfomycin monotherapy. | 2015 | 26108020 |
| septic pulmonary embolism caused by a klebsiella pneumoniae liver abscess: clinical characteristics, imaging findings, and clinical courses. | septic pulmonary embolism caused by a klebsiella (k.) pneumoniae liver abscess is rare but can cause considerable morbidity and mortality. however, clinical information regarding this condition is limited. this study was conducted to elucidate the full disease spectrum to improve its diagnosis and treatment. | 2015 | 26106957 |
| biosynthesis of 2-deoxysugars using whole-cell catalyst expressing 2-deoxy-d-ribose 5-phosphate aldolase. | 2-deoxy-d-ribose 5-phosphate aldolase (dera) accepts a wide variety of aldehydes and is used in de novo synthesis of 2-deoxysugars, which have important applications in drug manufacturing. however, dera has low preference for non-phosphorylated substrates. in this study, dera from klebsiella pneumoniae (kdera) was mutated to increase its enzyme activity and substrate tolerance towards non-phosphorylated polyhydroxy aldehyde. mutant kdera(k12) (s238d/f200i/δy259) showed a 3.15-fold improvement in ... | 2015 | 26104867 |
| plasmid-mediated antibiotic resistance and virulence in gram-negatives: the klebsiella pneumoniae paradigm. | plasmids harbor genes coding for specific functions including virulence factors and antibiotic resistance that permit bacteria to survive the hostile environment found in the host and resist treatment. together with other genetic elements such as integrons and transposons, and using a variety of mechanisms, plasmids participate in the dissemination of these traits, resulting in the virtual elimination of barriers among different kinds of bacteria. in this article we review the current informatio ... | 2014 | 26104358 |
| genome sequence of a klebsiella pneumoniae sequence type 258 isolate with prophage-encoded k. pneumoniae carbapenemase. | we present the draft genome sequence of a klebsiella pneumoniae carbapenemase (kpc)-producing sequence type 258 (st258) k. pneumoniae strain, st258_fl. uniquely, strain st258_fl harbors two copies of the blakpc gene on the chromosome, one of which is integrated into a prophage. | 2015 | 26089425 |
| severe hepatoxicity caused by aspirin overdose: a case report. | we report here the rare case of a 61-year-old man with multiple organ dysfunction caused by an aspirin overdose (4 g orally). the patient presented with a fever that reached 39.2 °c, a peptic ulcer, and massive upper gastrointestinal bleeding. his blood test results were as follows: white blood cell count, 1.8 × 10(9)/l; absolute lymphocytes, 0.4 × 10(9)/l; absolute neutrophils, 1.2 × 10(9)/l; and electrolyte disturbances. a computed tomography (ct) scan showed evidence of bilateral inferior pul ... | 2015 | 26085469 |
| capsular polysaccharide is involved in nlrp3 inflammasome activation by klebsiella pneumoniae serotype k1. | klebsiella pneumoniae (strain 43816, k2 serotype) induces interleukin-1β (il-1β) secretion, but neither the bacterial factor triggering the activation of these inflammasome-dependent responses nor whether they are mediated by nlrp3 or nlrc4 is known. in this study, we identified a capsular polysaccharide (k1-cps) in k. pneumoniae (ntuh-k2044, k1 serotype), isolated from a primary pyogenic liver abscess (pla k. pneumoniae), as the klebsiella factor that induces il-1β secretion in an nlrp3-, asc-, ... | 2015 | 26077758 |
| molecular epidemiology and characterization of an outbreak causing klebsiella pneumoniae clone carrying chromosomally located bla(ctx-m-15) at a german university-hospital. | multi-drug resistant klebsiella pneumoniae strains are a common cause of health care associated infections worldwide. clonal spread of klebsiella pneumoniae isolates carrying plasmid mediated ctx-m-15 have been commonly reported. limited data is available regarding dissemination of chromosomally encoded ctx-m-15 in klebsiella pneumoniae worldwide. | 2015 | 26077154 |
| molecular structures and ion mobility cross sections: analysis of the effects of he and n2 buffer gas. | an empirically observed correlation between ion mobility cross sections in helium and nitrogen buffer gases was examined as a function of temperature, molecular size, and shape. experimental cross sections were determined for tetraglycine, bradykinin, angiotensin 2, melittin, and ubiquitin at 300 k and in the range from 80 to 550 k on home-built instruments and calculated by the projection superposition approximation (psa) method. the psa was also used to predict cross sections for larger system ... | 2015 | 26076363 |
| reply to "distribution of genotypes between ctx-m-producing and non-extended-spectrum-β-lactamase-producing klebsiella pneumoniae isolates". | | 2015 | 26071569 |
| distribution of genotypes between ctx-m-producing and non-extended-spectrum-β-lactamase-producing klebsiella pneumoniae isolates. | | 2015 | 26071568 |
| three dimensional checkerboard synergy analysis of colistin, meropenem, tigecycline against multidrug-resistant clinical klebsiella pneumonia isolates. | the spread of carbapenem-non-susceptible klebsiella pneumoniae strains bearing different resistance determinants is a rising problem worldwide. especially infections with kpc (klebsiella pneumoniae carbapenemase) - producers are associated with high mortality rates due to limited treatment options. recent clinical studies of kpc-blood stream infections revealed that colistin-based combination therapy with a carbapenem and/or tigecycline was associated with significantly decreased mortality rates ... | 2015 | 26067824 |
| an outbreak of colistin-resistant klebsiella pneumoniae carbapenemase-producing klebsiella pneumoniae in the netherlands (july to december 2013), with inter-institutional spread. | we describe an outbreak of klebsiella pneumoniae carbapenemase (kpc)-producing klebsiella pneumoniae (kpc-kp) st258 that occurred in two institutions (a hospital and a nursing home) in the netherlands between july and december 2013. in total, six patients were found to be positive for kpc-kp. all isolates were resistant to colistin and exhibited reduced susceptibility to gentamicin and tigecycline. in all settings, extensive environmental contamination was found. whole genome sequencing revealed ... | 2015 | 26067658 |
| comment on: infections caused by kpc-producing klebsiella pneumoniae: differences in therapy and mortality in a multicentre study. | | 2015 | 26066584 |
| tir-domain-containing adaptor-inducing interferon-β (trif) mediates antibacterial defense during gram-negative pneumonia by inducing interferon-x03b3. | klebsiella pneumoniae is an important cause of gram-negative pneumonia and sepsis. mice deficient for tir-domain-containing adaptor-inducing interferon-β (trif) demonstrate enhanced bacterial growth and dissemination during klebsiella pneumonia. we show here that the impaired antibacterial defense of trif mutant mice is associated with absent interferon (ifn)-x03b3; production in the lungs. ifn-x03b3; production by splenocytes in response to k. pneumoniae in vitro was critically dependent on tol ... | 2015 | 26065469 |
| emergence of carbapenem-resistant klebsiella pneumoniae: progressive spread and four-year period of observation in a cardiac surgery division. | frequent use of carbapenems has contributed to the increase to k. pneumoniae strains resistant to this class of antibiotics (crkp), causing a problem in the clinical treatment of patients. this investigation reports the epidemiology, genetic diversity, and clinical implication of the resistance to drugs mediated by crkp in our hospital. a total of 280 k. pneumoniae strains were collected; in particular 98/280 (35%) were crkp. sequencing analysis of crkp isolated strains showed that 9/98 of mbl-p ... | 2015 | 26064962 |
| in vitro activity of imipenem and colistin against a carbapenem-resistant klebsiella pneumoniae isolate coproducing shv-31, cmy-2, and dha-1. | we investigated the synergism of colistin and imipenem against a multidrug-resistant k. pneumoniae isolate which was recovered from a severe hip infection. pcr and dna sequencing were used to characterize the outer membrane porin genes and the resistance genes mediating the common β-lactamases and carbapenemases. synergism was evaluated by time-kill studies. the bla shv-31, bla cmy-2, and bla dha-1 were detected. outer membrane porin genes analysis revealed loss of ompk36 and frame-shift mutatio ... | 2015 | 26064923 |
| aeromonas punctata derived depolymerase improves susceptibility of klebsiella pneumoniae biofilm to gentamicin. | to overcome antibiotic resistance in biofilms, enzymes aimed at biofilm dispersal are under investigation. in the present study, applicability of an aeromonas punctata derived depolymerase capable of degrading the capsular polysaccharide (cps) of klebsiella pneumoniae, in disrupting its biofilm and increasing gentamicin efficacy against biofilm was investigated. | 2015 | 26063052 |
| genome-wide identification of klebsiella pneumoniae fitness genes during lung infection. | klebsiella pneumoniae is an urgent public health threat because of resistance to carbapenems, antibiotics of last resort against gram-negative bacterial infections. despite the fact that k. pneumoniae is a leading cause of pneumonia in hospitalized patients, the bacterial factors required to cause disease are poorly understood. insertion site sequencing combines transposon mutagenesis with high-throughput sequencing to simultaneously screen thousands of insertion mutants for fitness defects duri ... | 2015 | 26060277 |
| the changing epidemiology of hospital outbreaks due to esbl-producing klebsiella pneumoniae: the ctx-m-15 type consolidation. | klebsiella pneumoniae is responsible for a large number of hospital outbreaks. in the 1990s, there were clonal epidemics, affecting mostly intensive care patients, which carried shv and tem enzyme types. with the advent of ctx-m-15 enzymes in the 2000, plasmids encoding multiple extended-spectrum β-lactamase (esbl) types were described and, frequently, nosocomial outbreaks reported polyclonal dissemination and involved multiple enterobacteriaceae. worryingly, the interface between community and ... | 2015 | 26059626 |
| r-acetoin accumulation and dissimilation in klebsiella pneumoniae. | klebsiella pneumoniae is a 2,3-butanediol producer, and r-acetoin is an intermediate of 2,3-butanediol production. r-acetoin accumulation and dissimilation in k. pneumoniae was studied here. a budc mutant, which has lost 2,3-butanediol dehydrogenase activity, accumulated high levels of r-acetoin in culture broth. however, after glucose was exhausted, the accumulated r-acetoin could be reused by the cells as a carbon source. acetoin dehydrogenase enzyme system, encoded by acoabcd, was responsible ... | 2015 | 26059458 |
| distinct contributions of neutrophils and ccr2+ monocytes to pulmonary clearance of different klebsiella pneumoniae strains. | klebsiella pneumoniae is a common respiratory pathogen, with some strains having developed broad resistance to clinically available antibiotics. humans can become infected with many different k. pneumoniae strains that vary in genetic background, antibiotic susceptibility, capsule composition, and mucoid phenotype. genome comparisons have revealed differences between k. pneumoniae strains, but the impact of genomic variability on immune-mediated clearance of pneumonia remains unclear. experiment ... | 2015 | 26056382 |
| aerobactin, but not yersiniabactin, salmochelin, or enterobactin, enables the growth/survival of hypervirulent (hypermucoviscous) klebsiella pneumoniae ex vivo and in vivo. | the siderophore aerobactin is the dominant siderophore produced by hypervirulent klebsiella pneumoniae (hvkp) and was previously shown to be a major virulence factor in systemic infection. however, strains of hvkp commonly produce the additional siderophores yersiniabactin, salmochelin, and enterobactin. the roles of these siderophores in hvkp infection have not been optimally defined. to that end, site-specific gene disruptions were created in hvkp1 (wild type), resulting in the generation of h ... | 2015 | 26056379 |
| the use of whole-genome sequencing for molecular epidemiology and antimicrobial surveillance: identifying the role of incx3 plasmids and the spread of blandm-4-like genes in the enterobacteriaceae. | to characterise the resistome of a multi-drug resistant klebsiella pneumoniae (kp0003) isolated from an australian traveller who was repatriated to a sydney metropolitan hospital from myanmar with possible prosthetic aortic valve infective endocarditis. | 2015 | 26056157 |
| [comparative evaluation of antimicrobial activity of oligochitosans against klebsiella pneumoniae]. | antibacterial activity of chitosan with different molecular weight at different ph values against gram-negative klebsiella pneumoniae was studied. it was found that the dependence of inhibition activity of chitosan on its molecular weight was inversed when the medium ph was increased above 7.0. in acidic media higher molecular weight chitosan had the higher antibacterial activity was occured while and in weak alkaline media oligomeric forms of chitosan displayed the inhibition effect only. our r ... | 2015 | 26050473 |
| clinical effect of biapenem on nursing and healthcare-associated pneumonia (nhcap). | the clinical effect of biapenem (bipm) on nursing and healthcare-associated pneumonia (nhcap) was evaluated. one hundred and three nhcap patients (group b: 52 patients, group c: 51 patients) to whom bipm was administered were included in this study. clinical effect, bacteriological effect, and adverse events were examined. results revealed efficacy in 45 of 52 patients (efficacy rate: 86.5%) of nhcap group b, and 43 of 51 patients (efficacy rate: 84.3%) of nhcap group c, 88 of 103 patients (effi ... | 2015 | 26050019 |
| duox2 promotes the elimination of the klebsiella pneumoniae strain k5 from t24 cells through the reactive oxygen species pathway. | dual oxidase 2 (duox2) plays a major role in host defense in intestinal and airway epithelial cells through the reactive oxygen species (ros) pathway. klebsiella pneumoniae is a uropathogen that causes urinary tract infections. it is not known whether duox2 plays a role in host defense in bladder cancer epithelial cells. it is also not known whether klebsiella pneumoniae invades t24 human bladder carcinoma cells and whether duox2 plays a role in eliminating the klebsiella pneumoniae strain k5 th ... | 2015 | 26046128 |
| phenotypic and molecular characterization of plasmid mediated ampc among clinical isolates of klebsiella pneumoniae isolated from different hospitals in tehran. | klebsiella pneumoniae is one of the main opportunistic pathogens which can cause different types of infections. production of beta-lactamases like ampc and esbl mostly lead to beta-lactam resistance in these gram-negative bacteria. the aim of this study was the detection of ampc-producing k. pneumoniae in clinical isolates. | 2015 | 26046018 |
| successful treatment of refractory majocchi's granuloma with voriconazole and review of published literature. | majocchi's granuloma (mg) is a rare deep skin dermatophyte infection that can occur either in immunocompetent or in immunocompromised individuals. oral itraconazole or terbinafine is considered to be the first choice of treatment. we report an immunocompetent man with deep nodular form of mg, the form which is generally found in immunosuppressed individuals. previous treatment with either oral itraconazole or terbinafine yielded no apparent improvement. after a series of examination, the man was ... | 2015 | 26045285 |
| klebsiella pneumoniae survives within macrophages by avoiding delivery to lysosomes. | klebsiella pneumoniae is an important cause of community-acquired and nosocomial pneumonia. evidence indicates that klebsiella might be able to persist intracellularly within a vacuolar compartment. this study was designed to investigate the interaction between klebsiella and macrophages. engulfment of k. pneumoniae was dependent on host cytoskeleton, cell plasma membrane lipid rafts and the activation of phosphoinositide 3-kinase (pi3k). microscopy studies revealed that k. pneumoniae resides wi ... | 2015 | 26045209 |
| a case of acute postoperative keratitis after deep anterior lamellar keratoplasty by multidrug resistant klebsiella. | a healthy lady of 42 years underwent deep anterior lamellar keratoplasty for granular dystrophy. the very next day, it was complicated by development of infectious keratitis. the organism was identified as multidrug resistant klebsiella pneumoniae. donor corneal button may be implicated in the transmission of infection in an otherwise uneventful surgery and follow-up. nosocomial infections are usually severe, rapidly progressive and difficult to treat. finally, the lady had to undergo therapeuti ... | 2015 | 26044477 |
| destruction-free procedure for the isolation of bacteria from sputum samples for raman spectroscopic analysis. | lower respiratory tract infections are the fourth leading cause of death worldwide. here, a timely identification of the causing pathogens is crucial to the success of the treatment. raman spectroscopy allows for quick identification of bacterial cells without the need for time-consuming cultivation steps, which is the current gold standard to detect pathogens. however, before raman spectroscopy can be used to identify pathogens, they have to be isolated from the sample matrix, i.e., sputum in c ... | 2015 | 26041453 |
| role of capsular polysaccharides in biofilm formation: an afm nanomechanics study. | bacteria form biofilms to facilitate colonization of biotic and abiotic surfaces, and biofilm formation on indwelling medical devices is a common cause of hospital-acquired infection. although it is well-recognized that the exopolysaccharide capsule is one of the key bacterial components for biofilm formation, the underlying biophysical mechanism is poorly understood. in the present study, nanomechanical measurements of wild type and specific mutants of the pathogen, klebsiella pneumoniae, were ... | 2015 | 26034816 |
| contemporary resistance trends and mechanisms for the old antibiotics colistin, temocillin, fosfomycin, mecillinam and nitrofurantoin. | recently there has been a renewed interest in reviving older antimicrobial agents, particularly those with activity against multidrug-resistant gram-negative bacilli. because many such antimicrobials are not licensed in all countries, there is a paucity of international surveillance data, and none of these agents is part of any antimicrobial resistance surveillance on the level of the eu. some of the agents are used in lower urinary tract infection, whereas most available supranational surveilla ... | 2015 | 26027916 |
| intrapersonal mutation of rmpa and rmpa2: a reason for negative hypermucoviscosity phenotype and low virulence of rmpa-positive klebsiella pneumoniae isolates. | two klebsiella pneumoniae isolates were simultaneously recovered from blood and urine cultures of the same patient. both isolates were identical in genomic pulsotype by pulsed-field gel electrophoresis (pfge). however, the hypermucoviscosity phenotype was confirmed in the blood strain but not the urine strain. a previously unrelated liver abscess k. pneumoniae hypermucoviscous isolate was used as a control. pcr, dna cloning and sequencing for the plasmid-borne rmpa and rmpa2 genes and the chromo ... | 2015 | 27873663 |
| carbapenem-resistant klebsiella pneumoniae infections in a greek intensive care unit: molecular characterisation and treatment challenges. | acquisition of carbapenemase-producing klebsiella pneumoniae (cp-kp) strains poses a major threat to critically ill patients. the objectives of this study were to describe the epidemiology of cp-kp isolates as well as the clinical outcome associated with the corresponding infections and to identify risk factors for mortality of intensive care unit (icu) patients in a greek hospital. a prospective, observational study was conducted in a nine-bed general icu over a 2-year period (april 2010-march ... | 2015 | 27873660 |
| synergistic killing of ndm-producing mdr klebsiella pneumoniae by two 'old' antibiotics-polymyxin b and chloramphenicol. | combination therapy is an important option in the fight against gram-negative 'superbugs'. this study systematically investigated bacterial killing and the emergence of polymyxin resistance with polymyxin b and chloramphenicol combinations used against new delhi metallo-β-lactamase (ndm)-producing mdr klebsiella pneumoniae. | 2015 | 26023209 |
| pulmonary gangrene due to rhizopus spp., staphylococcus aureus, klebsiella pneumoniae and probable sarcina organisms. | pulmonary gangrene is a life-threatening condition, which represents the fulminant end of the infectious lung diseases usually caused by polymicrobial infection. aerobic and anaerobic bacteria act synergistically to produce massive tissue necrosis which might be augmented by the angioinvasive nature of fungi like mucor. we report a successfully treated case of pulmonary gangrene in a poorly controlled diabetic patient, which was associated with polymicrobial infection. it was caused by rhizopus ... | 2015 | 26022794 |
| inhibition of p-iκbα ubiquitylation by autophagy-related gene 7 to regulate inflammatory responses to bacterial infection. | klebsiella pneumoniae causes serious infections and healthcare burdens in humans. we have previously reported that the deficiency of autophagy-related gene (atg) 7 in macrophages (murine alveolar macrophage cell line [mh-s]) induced irregular host immunity against k. pneumoniae and worsened pathologic effects in the lung. in the current study, we investigated the molecular mechanism by which atg7 influenced k. pneumoniae-induced inflammatory responses. | 2015 | 26022442 |
| insights into 3-hydroxypropionic acid biosynthesis revealed by overexpressing native glycerol dehydrogenase in klebsiella pneumoniae. | in klebsiella pneumoniae, glycerol dissimilation involves parallel oxidation and reduction pathways. oxidation pathway provides adenosine triphosphate (atp) and cofactors to sustain cell growth, while reduction pathway presents 3-hydroxypropionic acid (3-hp) and 1,3-propanediol(1,3-pdo), which are commercially attractive platform chemicals. previous metabolic engineering of k. pneumoniae focused on the intensification of reduction pathway; however, it failed to overproduce 3-hp or 1,3-pdo. contr ... | 2014 | 26019560 |
| 67ga spect/ct in diagnosis and follow-up of acute bacterial prostatitis. | we report a case of 63-year-old man who had urinary tract infection with septic shock, klebsiella pneumoniae bacteremia, and bacteriuria. (67)ga spect/ct showed hot uptake in prostate gland, and acute bacterial prostatitis was diagnosed. after antibiotic treatment, follow-up (67)ga spect/ct revealed much less uptake in the prostate gland, suggesting remission of prostatitis. | 2015 | 26018684 |
| detection and characterization of oxa-48-producing klebsiella pneumoniae originated in bulgaria. | we report the identification of oxa-48-producing klebsiella pneumoniae, causing peritonitis in a cancer patient admitted to the oncology hospital in sofia. the isolate had reduced susceptibility to carbapenems but remained susceptible to extended-spectrum cephalosporins. pcr and sequencing confirmed the presence of blaoxa-48 gene flanked by two intact copies of is1999 on truncated δtn1999.1. this transposon was located on unusual non-typeable 29-kb plasmid that could be transferred only by trans ... | 2016 | 26017897 |
| unravelling of a mechanism of resistance to colistin in klebsiella pneumoniae using atomic force microscopy. | in this study we focused on the mechanism of colistin resistance in klebsiella pneumoniae. | 2015 | 26017037 |
| [what if it is not an acute pyelonephritis? a monocentric experience of renal infarcts]. | often the reduced contrast enhancement on ct renal imaging is radiologically interpreted as acute pyelonephritis (pna), but it is the task of the clinician to assess a possible differential diagnosis such as a renal infarct and look for a cause. | 2016 | 26005936 |
| central venous catheter as vascular approach for hemodialysis - our experiences. | application of a central venous catheter (cvc), as a temporary or permanent vascular access for hemodialysis, has been continuous practice at the sarajevo pediatric clinic, department of pediatric intensive care. the main goal of the article is to present our experiences with central venous catheters in the treatment of these patients. | 2015 | 26005388 |
| the influence of buda deletion on glucose metabolism related in 2,3-butanediol production by klebsiella pneumoniae. | klebsiella pneumoniae (k. pneumoniae), which is a promising microorganism for industrial bulk production of 2,3-butanediol (2,3-bdo), naturally converts glucose to 2,3-bdo. the 2,3-bdo biosynthesis from glucose is composed of three steps; α-acetolactate biosynthesis by α-acetolactate synthase (budb); acetoin biosynthesis by α-acetolactate decarboxylase (buda); and 2,3-bdo biosynthesis by acetoin reductase (budc). in an effort to understand the influence of blocked 2,3-bdo pathway on k. pneumonia ... | 2015 | 26002498 |
| influence of the bacterial phenotypes on the clinical manifestations in klebsiella pneumoniae bacteremia patients: a retrospective cohort study. | ninety-four episodes of klebsiella pneumoniae bloodstream infection were identified at a university hospital in japan. after excluding extended-spectrum beta lactamase-producing strains, 83 blood isolates from these patients were assayed in terms of their bacterial phenotypes such as the mucoid and hypermucoviscosity phenotypes. bacterial phenotypes were correlated with the patients' clinical manifestations. the hypermucoviscosity phenotype was significantly associated with septic shock at the o ... | 2015 | 26002138 |
| carbapenem resistance confers to klebsiella pneumoniae strains an enhanced ability to induce infection and cell death in epithelial tissue-specific in vitro models. | carbapenem-resistant klebsiella pneumoniae strains (kpc-kp) are emerging worldwide causing different nosocomial infections including those of the urinary tract, lung or skin wounds. for these strains, the antibiotic treatment is limited to only few choices including colistin, whose continuous use led to the emergence of carbapenem-resistant kpc-kp strains resistant also to this treatment (kpc-kp col-r). | 2015 | 26000649 |
| structural elucidation and biological studies of a novel exopolysaccaride from klebsiella pneumoniae pb12. | an exopolysaccharide (knps) of an average molecular weight ∼1.8×10(5) da was isolated from the culture medium of klebsiella pneumoniae pb12. structural characterization of knps was carried out using sugar and methylation analysis, smith degradation and 1d/2d nmr experiments. sugar analysis showed that the knps composed of arabinose, galactose, 3-o-methyl-galctose and glucose in a molar ratio of nearly 4:3:1:1. the proposed repeating unit of the knps has a backbone chain consisting of two (1→6)-g ... | 2015 | 25999015 |
| distribution of extended-spectrum β-lactamase types in a brazilian tertiary hospital. | epidemiological data on the prevalence of extended-spectrum β-lactamases (esbls) are scarce in brazil despite the fact that these data are essential for empirical treatment and control measures. the objective of this study was to evaluate the prevalence of different esbls by type and distribution in a tertiary hospital in southern brazil. | 2015 | 25992930 |
| residence in skilled nursing facilities is associated with tigecycline nonsusceptibility in carbapenem-resistant klebsiella pneumoniae. | to determine the rates of and risk factors for tigecycline nonsusceptibility among carbapenem-resistant klebsiella pneumoniae (crkps) isolated from hospitalized patients. | 2015 | 25990806 |
| klebsiella pneumoniae co-producing ndm-5 and oxa-181 carbapenemases, south korea. | | 2015 | 25988911 |
| effect of resistance mechanisms on the inoculum effect of carbapenem in klebsiella pneumoniae isolates with borderline carbapenem resistance. | we aimed to examine the effects of resistance mechanisms on several resistance phenotypes among carbapenem-resistant klebsiella pneumoniae isolates with borderline carbapenem mics. we compared carbapenemase-negative k. pneumoniae with carbapenemase-producing k. pneumoniae (cpkp) isolates with similar mics. cpkp isolates exhibited a marked inoculum effect and were more resistant to the bactericidal effect of meropenem. this suggests that mic measurements alone may not be sufficient in predicting ... | 2015 | 25987630 |
| tigecycline for carbapenem-resistant klebsiella pneumoniae infections in the intensive care unit. | | 2015 | 25986909 |
| interhospital spread of ndm-7-producing klebsiella pneumoniae belonging to st437 in spain. | this study describes an interhospital spread of carbapenem-resistant klebsiella pneumoniae (crkp) producing ndm-7 carbapenemase that started in december 2013 in madrid, spain. ndm-7-producing crkp were isolated from urine, rectal swabs or blood samples from seven patients admitted to three different hospitals (hospital universitario la paz, hospital de cantoblanco and hospital central de la cruz roja). the isolates were resistant to all antimicrobials tested except colistin and fosfomycin. one b ... | 2015 | 25982912 |
| retrospective detection of the hidden spread of oxa-48-producing klebsiella pneumoniae in a french teaching hospital. | | 2015 | 25982027 |
| atomic force microscopy reveals the mechanobiology of lytic peptide action on bacteria. | increasing rates of antimicrobial-resistant medically important bacteria require the development of new, effective therapeutics, of which antimicrobial peptides (amps) are among the promising candidates. many amps are membrane-active, but their mode of action in killing bacteria or in inhibiting their growth remains elusive. this study used atomic force microscopy (afm) to probe the mechanobiology of a model amp (a derivative of melittin) on living klebsiella pneumoniae bacterial cells. we perfo ... | 2015 | 25978768 |
| draft genome sequences of four ndm-1-producing klebsiella pneumoniae strains from a health care facility in northern california. | we report the draft genome sequences of klebsiella pneumoniae strains from four patients at a northern california health care facility. all strains contained the new delhi metallo-β-lactamase (ndm1) carbapenemase with extended antibiotic resistance, including resistance to expanded-spectrum cephalosporins, imipenem, ertapenem, and meropenem. ndm gene alignments revealed that the resistance was plasmid encoded. | 2015 | 25977423 |
| long-term, low-dose tigecycline to treat relapsing bloodstream infection due to kpc-producing klebsiella pneumoniae after major hepatic surgery. | a 68-year-old male underwent a right hepatectomy, resection of the biliary convergence, and a left hepatic jejunostomy for a klatskin tumour. the postoperative course was complicated by biliary abscesses with relapsing bloodstream infections due to klebsiella pneumoniae carbapenemase (kpc)-producing klebsiella pneumoniae (kpc-kp). a 2-week course of combination antibiotic therapy failed to provide source control and the bacteraemia relapsed. success was obtained with a regimen of tigecycline 100 ... | 2015 | 25975648 |
| what caused the outbreak of esbl-producing klebsiella pneumoniae in a neonatal intensive care unit, germany 2009 to 2012? reconstructing transmission with epidemiological analysis and whole-genome sequencing. | we aimed to retrospectively reconstruct the timing of transmission events and pathways in order to understand why extensive preventive measures and investigations were not sufficient to prevent new cases. | 2015 | 25967999 |
| improvement of 1,3-propanediol production in klebsiella pneumoniae by moderate expression of puuc (encoding an aldehyde dehydrogenase). | to improve 1,3-propanediol production in klebsiella pneumoniae, the effects of puuc expression in lactate- and lactate/2,3-butanediol-deficient strains were assessed. | 2015 | 25957564 |
| characterization of extended-spectrum beta-lactamases and antimicrobial resistance of klebsiella pneumoniae in intra-abdominal infection isolates in latin america, 2008-2012. results of the study for monitoring antimicrobial resistance trends. | the study for monitoring antimicrobial resistance trends has monitored the in vitro activity of several recommended antimicrobials used in the management of intra-abdominal infections (iais) globally since 2002. in this report, we document the changing susceptibility patterns to recommended antimicrobials in klebsiella pneumoniae isolates from patients with iais in 11 latin american countries between 2008 and 2012 and describe the beta-lactamases encoded by phenotypically extended-spectrum beta- ... | 2015 | 25956930 |