Publications

TitleAbstractYear
Filter
PMID
Filter
[studies on the importance of complement binding antibodies for plasmodium berghei infection in mice]. 196514343724
[studies on the effect of the infection dose on the survival time in plasmodium berghei infection in mice]. 196514343725
electron microscopy of plasmodium berghei. i. on the migration of trophozoites from infected erythrocytes in the rat. 196514347459
[appearance of immunity against plasmodium berghei in mice subjected to milk diet or to sulfonamide therapy]. 195514350363
[experimental immunological study of paludism with plasmodium berghei]. 195414350825
[absence of cross immunity between plasmodium berghei and plasmodium vinckei in infections in young rats]. 195414352552
[research on plasmodium berghei malaria in laboratory mice. i. some factors with a possible influence on the severity of the infection]. 195514362142
[some observations with reference to immunity to plasmodium berghei]. 195414362172
[plasmodium berghei infections in milk-fed splenectomized rats]. 195414372842
[research on plasmodium berghei (vincke and lips) infection in laboratory mice. ii. chemotherapeutic trials]. 195514377160
[development of plasmodium berghei infection in mice in the midi (france)]. 195414378917
[development of plasmodium berghei infection in newborn rats]. 195414378933
symposium on plasmodium berghei. 195414391875
a written symposium on plasmodium berghei vincke and lips, 1948; introduction. 195414391876
the history of the discovery of plasmodium berghei. 195414391877
natural history of plasmodium berghei. 195414391878
experimental transmission of plasmodium berghei. 195414391879
the mosquito transmission of plasmodium berghei. 195414391880
plasmodium berghei and chemotherapy. 195414391881
some physiological and pathological processes in plasmodium berghei infections in white rats. 195414391882
on some problems arising from the observation of the infection with plasmodium berghei in mice and rats. 195414391883
studies on plasmodium berghei vincke and lips, 1948. xx. a physiological change observed in sulphadiazine resistant strain. 195414391884
some host-parasite relationships in plasmodium berghei infections. 195414391886
malaria and nutrition with special reference to plasmodium berghei infections in rats. 195414391887
experimental study on the immunology of malaria due to plasmodium berghei. 195414391888
immunology of plasmodium berghei. 195414391889
investigations on immunity to plasmodium berghei infection in mice. 195414391890
the absence of cross immunity between plasmodium berghei (vincke and lips) and plasmodium vinckei (rodhain). 195414391891
some observations about immunity to plasmodium berghei. 195414391892
pathological and immunological host-parasite relationships between albino rat and plasmodium berghei. 195414391893
[effect of various diets on the development of plasmodium berghei in the white mouse]. 195514393134
[reappearance of the process of extraflagellation in a strain of plasmodium berghei regularly maintained by mechanical passage]. 195914406483
[studies on the experimental production of resistance to various antimalarial products in a strain of plasmodium berghei]. 195914441979
[influence of vitamins b 12, c and k 1 in the treatment of plasmodium berghei infections using chloroquine]. 195914441980
the effect of anti-erythrocytic antibodies upon plasmodium berghei infections in white mice. 196014444152
the behaviour of plasmodium berghei and plasmodium vinckei in the spiny mouse acomys cahirinus. 196114448536
[resistance and immunity in plasmodium berghei infected mice]. 196214459599
[the course of infection and clinical picture of plasmodium berghei-infected nmri strain mice]. 196114459600
experimental lysin-deficiency in rats infected with plasmodium berghei. 196214467528
metastatic calcification induced by hytakerol in rats infected with plasmodium berghei. 196214472743
studies on plasmodium berghei vincke and lips, 1948. xxxi. selection of a primaquine resistant strain. 196114488472
studies on plasmodium berghei vincke and lips, 1948. xxx. effects of splenectomy on the course of blood-induced infection in rats. 196114488473
studies on plasmodium berghei vincke and lips, 1948. xxix. the size of parasite population and its relation to the selection of a strain resistant to sulphadiazine. 196114490070
why is the plasmodium falciparum hexose transporter a promising new drug target?chemotherapy of malaria parasites is limited by established drug resistance and lack of novel treatment options. intraerythrocytic stages of plasmodium falciparum, the causative agent of severe malaria, are wholly dependent upon host glucose for energy. a facilitative hexose transporter (pfht), encoded by a single-copy gene, mediates glucose uptake and is therefore an attractive potential target. the authors first established heterologous expression in xenopus laevis to allow functional characte ...200314498822
erythrocyte g protein-coupled receptor signaling in malarial infection.erythrocytic mechanisms involved in malarial infection are poorly understood. we have found that signaling via the erythrocyte beta2-adrenergic receptor and heterotrimeric guanine nucleotide-binding protein (galphas) regulated the entry of the human malaria parasite plasmodium falciparum. agonists that stimulate cyclic adenosine 3',5'-monophosphate production led to an increase in malarial infection that could be blocked by specific receptor antagonists. moreover, peptides designed to inhibit ga ...200314500986
quinine distribution in mice with plasmodium berghei malaria.the disposition of a single 80 mg/kg injection of quinine base was compared in control and plasmodium berghei-infected mice. pharmacokinetic parameters were determined on repeated whole blood samples from caudal vein (experiment 1) and quinine distribution was evaluated in tissues and blood fractions from mice sacrificed two hours post dosing (experiment 2). quinine concentrations were assessed by high performance liquid chromatography with fluorometric detection. whole blood concentrations and ...200314503660
rodent malaria in the natural host--irradiated sporozoites of plasmodium berghei induce liver-stage specific immune responses in the natural host grammomys surdaster and protect immunized grammomys against p. berghei sporozoite challenge.the choice of the host in studying host-parasite interactions is of crucial importance, and the use of a natural host is most appropriate in answering pertinent questions related to human malaria. the grammomys surdaster is the natural host and reservoir of the rodent malaria parasite plasmodium berghei. this natural host is difficult to protect by irradiated sporozoite immunization, a situation comparable to what has been observed in humans with p. falciparum. this is in contrast to the complet ...200114513935
8-quinolinamines and their pro prodrug conjugates as potent blood-schizontocidal antimalarial agents.synthesis and antimalarial activities of n8-(4-amino-1-methylbutyl)-5-alkoxy-4-ethyl-6-methoxy-8-quinolinamines (5) and their pro prodrug analogues (6-7) prepared by covalently linking 5 to the redox-sensitive (8) and esterase-sensitive (9) linkers through the amide linkage are reported. the most effective 8-quinolinamines [5c (r=c5h11) and 5f (r=c8h17)] have exhibited in vitro and in vivo biological efficacy superior to that of the standard drug chloroquine against both drug-sensitive and drug- ...200314527552
rheumatoid factor-like igm in plasmodium berghei (apicomplexa: haemosporida) infections of balb/c mice.groups of female balb/c mice infected by intravenous injection with 50 erythrocytes containing plasmodium berghei vincke et lips, 1948 were sacrificed on days 3 through 12 after infection. rheumatoid factor-like igm (rf-igm) and parasite-specific igg levels were determined by enzyme-linked immunosorbent assay in serum specimens and in culture medium removed from spleen cell cultures established at sacrifice. all four mouse igg subisotypes were recognized by rf-igm molecules induced by plasmodium ...200314535342
plasmepsin 4, the food vacuole aspartic proteinase found in all plasmodium spp. infecting man.plasmepsins are aspartic proteinases of the malaria parasite, and seven groups of plasmepsins have been identified by comparing genomic sequence data available for the genes encoding these enzymes from plasmodium falciparum, plasmodium vivax, plasmodium knowlesi, plasmodium berghei, and plasmodium yoelii. the food vacuole plasmepsins typified by plasmepsin 4 from p. falciparum (pfpm4) constitute one of these groups. genes encoding the ortholog of pfpm4 have been cloned from plasmodium ovale, pla ...200314550891
heterologous promoter activity in stable and transient plasmodium knowlesi transgenes. 200314550898
[genetic analysis of host resistance to rodent malaria in mice]. 200314562624
identification and expression analysis of abc genes in plasmodium yoelii and p. berghei.the atp-binding cassette (abc) proteins are one of the largest evolutionarily conserved families. they are characterized by the presence of highly conserved nucleotide-binding sites (nbs). in the present study, we identified abc genes in rodent plasmodia. we queried the plasmodium yoelii genome with the abc signature motif and retrieved 15 contigs. sequences were classified into seven abc families by blast comparison. conservation of the five signature abc motifs in the p. yoelii contigs was exa ...200414564508
inhibition of platelet adherence to brain microvasculature protects against severe plasmodium berghei malaria.some patients with plasmodium falciparum infections develop cerebral malaria, acute respiratory distress, and shock and ultimately die even though drug therapy has eliminated the parasite from the blood, suggesting that a systemic inflammatory response contributes to malarial pathogenesis. plasmodium berghei-infected mice are a well-recognized model of severe malaria (experimental severe malaria [esm]), and infected mice exhibit a systemic inflammatory response. because platelets are proposed to ...200314573677
baculovirus virions displaying plasmodium berghei circumsporozoite protein protect mice against malaria sporozoite infection.the display of foreign proteins on the surface of baculovirus virions has provided a tool for the analysis of protein-protein interactions and for cell-specific targeting in gene transfer applications. to evaluate the baculovirus display system as a vaccine vehicle, we have generated a recombinant baculovirus (acnpv-cspsurf) that displays rodent malaria plasmodium berghei circumsporozoite protein (pbcsp) on the virion surface as a fusion protein with the major baculovirus envelope glycoprotein g ...200314599800
protection of mice infected with plasmodium berghei by bacillus thuringiensis crystal proteins.eight bacillus thuringiensis strains were used to test their activity against plasmodium berghei. when crystal proteins extracted from strains 007, 017, 020, 021, 030, 032, and 037 were injected into plasmodium-infected mice through the tail vein at a rate of 0.45-1.5 mg per mouse, the lengths of survival for the mice were extended up to 5 days (from 8.5 days to 13.5-15 days). blood-cell staining demonstrated that normal erythrocytes were lightly stained and regularly shaped while the erythrocyt ...200414600831
isolation of plasmodium berghei ookinetes in culture using nycodenz density gradient columns and magnetic isolation.background: large scale in vitro production of the mosquito stages of malaria parasites remains elusive, with only limited success for complete sporogonic development and only one report of development through to infective sporozoites. the initial step in this process is the production, in vitro, of ookinetes from gametocytaemic blood. methods for isolation of these ookinetes from blood cells have been described; however, in addition to yield often being low, processing time and potential for co ...200314613512
in-vivo antimalarial activity of some oxygenated xanthones.a series of oxygenated xanthones was prepared so that the antimalarial activity of each compound could be evaluated in vivo, using 4-day suppressive assays against plasmodium berghei anka in balb/c mice. when given in a dose of 20 mg/kg.day for 4 days, most of the compounds produced significant chemosuppression of parasitaemia. the most active compound was 1,3,6,8-tetrahydroxyxanthone, which reduced the percentage of erythrocytes infected by 70.5%, followed by norlichexanthone (44.3%) and its is ...200314613627
the role of reactive oxygen species on plasmodium melanotic encapsulation in anopheles gambiae.malaria transmission depends on the competence of some anopheles mosquitoes to sustain plasmodium development (susceptibility). a genetically selected refractory strain of anopheles gambiae blocks plasmodium development, melanizing, and encapsulating the parasite in a reaction that begins with tyrosine oxidation, and involves three quantitative trait loci. morphological and microarray mrna expression analysis suggest that the refractory and susceptible strains have broad physiological difference ...200314623973
analysis of the plasmodium and anopheles transcriptomes during oocyst differentiation.understanding the life cycle of the malaria parasite in its mosquito vector is essential for developing new strategies to combat this disease. subtractive hybridization cdna libraries were constructed that are enriched for plasmodium berghei and anopheles stephensi genes expressed during oocyst differentiation on the midgut. sequencing of 1485 random clones led to the identification of 1137 unique expressed sequence tags. of the 608 expressed sequence tags with data base hits, 320 (53%) had sign ...200414627711
analysis of the plasmodium and anopheles transcriptional repertoire during ookinete development and midgut invasion.plasmodium, the causative agent of malaria, has to undergo sexual differentiation and development in anopheline mosquitoes for transmission to occur. to isolate genes specifically induced in both organisms during the early stages of plasmodium differentiation in the mosquito, two cdna libraries were constructed, one enriched for sequences expressed in differentiating plasmodium berghei ookinetes and another enriched for sequences expressed in anopheles stephensi guts containing invading ookinete ...200414627712
malaria parasites lacking eef1a have a normal s/m phase yet grow more slowly due to a longer g1 phase.eukaryotic elongation factor 1a (eef1a) plays a central role in protein synthesis, cell growth and morphology. malaria parasites possess two identical genes encoding eef1a (eef1aa and eef1ab). using pbeef1a-plasmodium berghei mutants that lack an eef1a gene, we demonstrate that the level of eef1a production affects the proliferation of blood stages and parasite fitness. pbeef1a- parasites can complete the vertebrate and mosquito phases of the life cycle, but the growth phase of the asexual blood ...200314651637
the plasmodium circumsporozoite protein is involved in mosquito salivary gland invasion by sporozoites.plasmodium sporozoites develop in oocysts on the midgut wall of the mosquito and are released into the hemocoel. approximately 15-20% of oocyst sporozoites will successfully attach to and invade salivary glands, their target organ. we have previously shown that the major surface protein of sporozoites, the circumsporozoite (cs) protein, binds specifically to salivary glands and not to other mosquito organs exposed to circulating hemolymph. in addition, a peptide from the n-terminal portion of cs ...200414668012
combination effects of chloroquine with the febrifugine and isofebrifugine mixture against a blood-induced infection with chloroquine-resistant plasmodium berghei nk65 in icr mice.the combination effects of chloroquine with a mixture of febrifugine and isofebrifugine were evaluated against a blood-induced infection with chloroquine-resistant p. berghei nk65 in icr mice. mice in the untreated control showed a progressively increasing parasitemia leading to mouse death. a two-day dosage of 20 mg base/kg of chloroquine alone showed little effect against p. berghei nk65 infection, and all mice died from day 13 to 14 with an increasing parasitemia. a four-day dosage of 1 mg/kg ...200314669265
activation of transforming growth factor beta by malaria parasite-derived metalloproteinases and a thrombospondin-like molecule.much of the pathology of malaria is mediated by inflammatory cytokines (such as interleukin 12, interferon gamma, and tumor necrosis factor alpha), which are part of the immune response that kills the parasite. the antiinflammatory cytokine transforming growth factor (tgf)-beta plays a crucial role in preventing the severe pathology of malaria in mice and tgf-beta production is associated with reduced risk of clinical malaria in humans. here we show that serum-free preparations of plasmodium fal ...200314676296
selection and reversal of plasmodium berghei resistance in the mouse model following repeated high doses of artemether.artemether, a derivative of artemisinin, is effectively used for the treatment of malaria without any clinically relevant resistance to date. artemether has also been developed as an antischistosomal agent, exhibiting highest activity against immature parasites. here, we employ a rodent model and investigate whether the proposed artemether treatment schedule to prevent schistosome-attributable morbidity might select for plasmodium berghei resistance. mice infected with an anka strain of p. bergh ...200414677058
gene targeting demonstrates that the plasmodium berghei subtilisin pbsub2 is essential for red cell invasion and reveals spontaneous genetic recombination events.the plasmodium merozoite proteases involved in the crucial process of erythrocyte invasion are promising targets for novel malaria control strategies. we report here the characterization of the subtilisin-like protease sub2 from the rodent parasites plasmodium berghei and plasmodium yoelii, leading the way to in vivo functional studies of this enzyme. the kinetics of expression and subcellular localization imply a central role for sub2 in erythrocyte invasion. through the use of gene targeting s ...200414678331
mice deficient in interleukin-4 (il-4) or il-4 receptor alpha have higher resistance to sporozoite infection with plasmodium berghei (anka) than do naive wild-type mice.balb/c interleukin-4 (il-4(-/-)) or il-4 receptor-alpha (il-4ralpha(-/-)) knockout (ko) mice were used to assess the roles of the il-4 and il-13 pathways during infections with the blood or liver stages of plasmodium in murine malaria. intraperitoneal infection with the blood-stage erythrocytes of plasmodium berghei (anka) resulted in 100% mortality within 24 days in balb/c mice, as well as in the mutant mouse strains. however, when infected intravenously with the sporozoite liver stage, 60 to 8 ...200414688111
effects of bisphosphonates on the growth of entamoeba histolytica and plasmodium species in vitro and in vivo.the effects of a series of 102 bisphosphonates on the inhibition of growth of entamoeba histolytica and plasmodium falciparum in vitro have been determined, and selected compounds were further investigated for their in vivo activity. forty-seven compounds tested were active (ic(50) < 200 microm) versus e. histolytica growth in vitro. the most active compounds (ic(50) approximately 4-9 microm) were nitrogen-containing bisphosphonates with relatively large aromatic side chains. simple n-alkyl-1-hy ...200414695831
folate-synthesizing enzyme system as target for development of inhibitors and inhibitor combinations against candida albicans-synthesis and biological activity of new 2,4-diaminopyrimidines and 4'-substituted 4-aminodiphenyl sulfones.the paper describes the design, synthesis, and testing of inhibitors of folate-synthesizing enzymes and of whole cell cultures of candida albicans. the target enzymes used were dihydropteroic acid synthase (syn) and dihydrofolate reductase (dhfr). several series of new 2,4-diaminopyrimidines were synthesized and tested as inhibitors of dhfr and compared with their activity against dhfr derived from mycobacteria and escherichia coli. to test for selectivity, also rat dhfr was used. a series of su ...200414695838
8-quinolinamines conjugated with amino acids are exhibiting potent blood-schizontocidal antimalarial activities.alanine, lysine, ornithine and valine conjugated to primaquine and other 8-quinolinamine antimalarials were prepared for blood-schizontocidal antimalarial activity evaluation. the analogues were examined in vivo against plasmodium berghei (drug-sensitive strain) and plasmodium yoelii nigeriensis (highly virulent multi-drug-resistant strain) infected mice models. n(1)-[4-(5-butoxy-4-ethyl-6-methoxy-8-quinolylamino)pentyl]-(2s)-2,6-diaminohexanamide (20) which showed curative activity at 5mg/kg in ...200414697789
discovery of a bulky 2-tert-butyl group containing primaquine analogue that exhibits potent blood-schizontocidal antimalarial activities and complete elimination of methemoglobin toxicity.to eliminate an unwarranted metabolic pathway of the quinoline ring, a set of two compounds, where c-2 position of the antimalarial drug primaquine is blocked by metabolically stable bulky alkyl group are synthesized. compound 2 [r = c(ch(3))(3)] of the series has produced excellent antimalarial efficacy against p. berghei and highly virulent multidrug-resistant p. yoelii nigeriensis strain in vivo. compound 2 was also evaluated for methemoglobin (methb) toxicity. this study describes the discov ...200414711300
cell-passage activity is required for the malarial parasite to cross the liver sinusoidal cell layer.liver infection is an obligatory step in malarial transmission, but it remains unclear how the sporozoites gain access to the hepatocytes, which are separated from the circulatory system by the liver sinusoidal cell layer. we found that a novel microneme protein, named sporozoite microneme protein essential for cell traversal (spect), is produced by the liver-infective sporozoite of the rodent malaria parasite, plasmodium berghei. targeted disruption of the spect gene greatly reduced sporozoite ...200414737184
the pharmacodynamic study of a potent new antimalarial (mc1).2,3-bis(trifluoromethyl)-4-(3-hydroxyquinuclidinylquinoline) or mc(1) is a new synthetic compound with potent antimalarial activity in vitro and in vivo studies. the ic(50) values of mc(1) and chloroquine in in vitro culture of plasmodium falciparum are 7.0x10(-8) and 6.06x10(-7)m, respectively. in an in vivo study using plasmodium berghei infected mice as the test model, the survival time of the infected mice without drug treatment was 6.00+0.58 days. chloroquine and mc(1) at an equal dose of 7 ...200414744560
naphthoquine phosphate and its combination with artemisinine.naphthoquine phosphate and artemisinine are two antimalarials developed in china. both drugs have proven to be efficacious and well tolerated as monotherapy as well as in combination in patients suffering from malaria. the co-naphthoquine, a novel antimalarial combination, is an oral fixed combination tablet of the naphthoquine phosphate and artemisinine. artemisinin is characterised by a rapid onset of schizonticidal action and a short half-life. parasite clearance is, however, often incomplete ...200414744564
a new modular protein of cryptosporidium parvum, with ricin b and lccl domains, expressed in the sporozoite invasive stage.the recombinant sa35 peptide has been described as an antigenic portion of a larger cryptosporidium parvum protein. we identified and characterized the encoding cpa135 gene and the entire protein, cpa135. the cpa135 gene was found to consist of a single exon of 4671 bp, and the mrna transcribed in the sporozoites was identified. the predicted 1556 amino-acid protein showed the presence of domains which are widely conserved also in other unrelated phylogenetic groups (i.e. a ricin b and a lccl mo ...200414747151
the action of antimalarial drugs in mice infected with plasmodium berghei. 195014777864
behaviour of plasmodium berghei in some rodents. 195014780155
[behavior of roussettus leachi toward plasmodium berghei]. 195014800009
[on the virulence of plasmodium berghei, hemosporidia of a rodent of central africa to the north african rodent meriones shawi]. 195014800475
susceptibility of the indian garden squirrel (sciurus palmarum) to plasmodium berghei and its asexual periodicity. 195114826832
[cyclic transmission of plasmodium berghei]. 195014830042
[the effect of chemotherapeutic agents on plasmodium berghei vincke & lips]. 195114837159
[plasmodium berghei infection in the white rat]. 195114839468
[sensibility of the golden hamster to plasmodium berghei vincke and lips 1948]. 195114839860
[behavior of cotton rat towards plasmodium berghei; complementary note]. 195114847384
[experiment in development of plasmodium berghei, vincke and lips in anopheles maculipennis (var. atroparvus)]. 195114847385
morphological changes in plasmodium berghei following proguanil, sulphadiazine and mepacrine therapy. 195114855618
[behavior of reinoculation hematozoa in the blood of rats cured of plasmodium berghei infection]. 195114870381
the effect of splenectomy on the course of plasmodium berghei infections in microtus guentheri. 195114873942
the effect of neoarsphenamine on plasmodium berghei infections in the mouse and rat: inhibition of the antimalarial action of neoarsphenamine by british anti-lewisite. 195114878394
studies on plasmodium berghei n. sp. vincke and lips, 1948. i. variations in susceptibility in albino mice. 195014880187
studies on plasmodium berghei n. sp. vincke and lips, 1948, ii. morphology, periodicity and pathogenicity in blood induced infections in mice, rats and garden squirrels. 195014880188
the course of the blood-induced plasmodium berghei infection in white mice. 195114889386
[peculiar immunity phenomena in plasmodium berghei infection]. 195114892299
[relation between plasmodium berghei and erythrocytes during the primary attack in the white rat]. 195114892300
[experimental plasmodium berghei infection of the rabbit]. 195114905184
[factors and significance of the prepatent period in experimental plasmodium berghei malaria]. 195114905222
[effect of splenectomy on white rats spontaneously recovered from experimental infection with plasmodium berghei]. 195114905661
[serologic study of experimental infection of the white rat with plasmodium berghei; disappearance of alexin. presence of complement fixing antibodies]. 195114905662
Displaying items 3301 - 3400 of 5568