| ionic requirements of [3h]gbr-12935 binding to the dopamine transporter in canine striatal membranes. | | 1992 | 1426538 |
| the regulation of microsomal glucose-6-phosphatase differs between liver and kidney. | | 1992 | 1426558 |
| effect of lipid peroxidation on molecular arrangement of phospholipids in liposomes prepared from egg yolk phosphatidylcholine or total rat brain lipids. a 31p nmr study. | changes in molecular arrangement of membrane phospholipids in the course of lipid autoxidation were studied by means of broad-band 31-p nmr spectroscopy. multilamellar liposomes prepared from egg yolk phosphatidylcholine (pc) or total lipid extracts from rat brains (tl) were used as models. the initial lamellar arrangement of phospholipids of both types changed as lipid peroxidation proceeded and a narrow isotropic signal appeared in the spectra at 0 ppm, this phenomenon being more prominent for ... | 1992 | 1426979 |
| engineering a humanized bispecific f(ab')2 fragment for improved binding to t cells. | we recently constructed a humanized bispecific antibody (bsf(ab')2v1) by separate e. coli expression of each fab' arm followed by directed chemical coupling in vitro. bsf(ab')2 v1 (anti-cd3/anti-p185her2) was demonstrated to retarget the cytotoxic activity of human cd3+ ctl in vitro against the human breast-tumor cell line, sk-br-3, which over-expresses the p185her2 product of the proto-oncogene her2. our minimalistic humanization strategy is to install as few murine residues as possible into a ... | 1992 | 1428403 |
| therapeutic considerations: lower respiratory tract infections in smokers. | tobacco smoke can alter both the structural and the immunologic defenses of the lungs against infection. the gases from smoke can also inhibit repair of the damages they create. smokers have been found to have increased bacterial adherence to the respiratory tract, decreased iga and igg, and a decrease in vital capacity two to three times greater than that of nonsmokers. these and other respiratory tract alterations put smokers at an added disadvantage when acute lower respiratory tract infectio ... | 1992 | 1429050 |
| selection of quinolone-resistant mutants of haemophilus influenzae and streptococcus pneumoniae. | | 1992 | 1429332 |
| concentrations of cefpodoxime in serum and bronchial mucosal biopsies. | cefpodoxime proxetil is a new orally administered cephalosporin which has a favorable spectrum of activity against respiratory pathogens. concentrations of cefpodoxime in serum and bronchial mucosal biopsy were measured in 13 patients without active respiratory tract infection undergoing fibreoptic bronchoscopy. samples were taken between 1 and 6 h after a single oral dose of cefpodoxime proxetil equivalent to 200 mg of cefpodoxime base. in twelve patients who completed the study, mean serum con ... | 1992 | 1429338 |
| use of chromosomal gene fusions to investigate the role of repetitive dna in regulation of genes involved in lipopolysaccharide biosynthesis in haemophilus influenzae. | the lic3 locus of haemophilus influenzae consists of four open reading frames. the derived amino acid sequences of orf2 and orf4 exhibit homology to escherichia coli gale and adk, respectively. the functions of orf1 and orf3 remain unknown. orf1 contains multiple tandem repeats of the tetrameric dna sequence caat near the 5' end. two possible translational starts (atg1 and atg2) lie upstream. we have used lacz fusions to investigate whether changes in the number of caat repeats in conjunction wi ... | 1992 | 1429450 |
| a study of the etiologies and treatment of nosocomial pneumonia in a community-based teaching hospital. | to compare the frequency of the pathogens of nosocomial pneumonia in a community-based teaching hospital to the frequencies previously published, and to evaluate recommendations for the therapy of nosocomial pneumonia in this setting. | 1992 | 1430999 |
| haemophilus influenzae type b purpura fulminans treated with hyperbaric oxygen. | we report the case of a 4-month-old child with purpura fulminans caused by haemophilus influenzae type b. in addition to conventional therapy, she was treated with hyperbaric oxygen, and made a full recovery. hyperbaric oxygen as an adjunct to other therapy in purpura fulminans is discussed. | 1992 | 1431173 |
| characterization of the serum antibody response to the capsular polysaccharide of haemophilus influenzae type b in children with invasive infections. | the serum antibody response to the capsular polysaccharide of haemophilus influenzae type b (hib) was studied in 30 children aged 1 day-5 years with invasive hib infections. from each child, serum was obtained 0-2 days, 5-11 days, 1 month, and 6-12 months after onset of symptoms. total antibodies were determined with ria and isotypes with elisa. only 2 children had antibody levels above the estimated protective level (0.15 microgram/ml) in the first serum sample. the antibody response was age de ... | 1992 | 1431250 |
| changes in the distribution of haemophilus influenzae type b clones associated with widespread infant vaccination in finland. | isolates from 646 consecutive finnish haemophilus influenzae type b (hib) patients with systemic disease, collected before and during large-scale vaccinations with hib conjugate vaccines, were analyzed by major outer membrane protein (omp) subtyping, lipopolysaccharide (lps) serotyping, and biotyping (bt). strains with omp-bt-lps combinations (clones) 1-i-1 and 1c-i-1 disappeared at the same rate as the disease they were associated with. a preferential decrease in the number of isolates of clone ... | 1992 | 1431251 |
| [dynamic process of colonization by haemophilus influenzae in children--is h. influenzae normal flora in the throat?]. | eighty-seven oropharyngeal isolates of haemophilus influenzae were obtained by two time cultures six months apart from a total of 288 children who attend a kindergarten. we analyzed the strains by comparing their serotypes, biotypes, beta-lactamase activity and by performing electrophoresis of outer membrane proteins on polyacrylamide gels. only nineteen strains were not identical, the rest of the 68 strains were classified into 23 types. during 6 months at least 15 types of strains lost from th ... | 1992 | 1431373 |
| from the centers for disease control and prevention. committee on immunization practices: pedvaxhib lots with questionable immunogenicity. | | 1992 | 1433752 |
| [antimicrobial activities of major oral antibacterial agents against clinically isolated microbial strains from outpatients with respiratory tract infection]. | minimum inhibitory concentrations (mics) were determined for major oral antibacterial agents for clinically isolated microbial strains from materials collected from outpatients with respiratory tract infections in 1988, 1989 and 1990, and the following conclusions were obtained. 1. methicillin-resistant staphylococcus aureus (mrsa) appeared to be responsible for community-acquired respiratory tract infections, but there also was a tendency showing that mrsa increased year by year. 2. a tendency ... | 1992 | 1433904 |
| [haemophilus influenzae pulmonary infection in patients infected with the human immunodeficiency virus]. | haemophilus influenzae has frequently been identified as the etiologic agent in pneumonias of patients with the human immunodeficiency virus (hiv) infection. the experience of the authors is reviewed and the significance of isolating this microorganism in respiratory samples commented upon. | 1992 | 1434998 |
| advisory committee on immunization practices update: report of pedvaxhib lots with questionable immunogenicity. | | 1992 | 1435679 |
| early mucosal changes in experimental sinusitis. | normal mucociliary flow is a significant defense mechanism in the prevention of acute sinusitis. we have undertaken a study to examine the early sinus mucosal and mucociliary changes that occur in response to acute infection. twenty rabbits were evaluated for 5 days after an obstructed maxillary sinus was inoculated with either streptococcus pneumoniae, hemophilus influenzae, pseudomonas aeruginosa, or a sterile saline solution. data collected included measurements of sinus mucosal ciliary beat ... | 1992 | 1437185 |
| infectious diseases and aids. | | 1992 | 1437921 |
| a periplasmic protein disulfide oxidoreductase is required for transformation of haemophilus influenzae rd. | the mutated gene in jg16, a haemophilus influenzae strain deficient in competence-induced dna binding and uptake, was cloned and the wild-type allele was sequenced. the gene was shown by northern analysis to be constitutively expressed on a 1.7-kilobase transcript. the gene product was identified as a 20.6-kda protein targeted to the periplasm. the protein contains the sequence cys-pro-his-cys (cphc) and is highly similar to two other periplasmic cphc motif-containing proteins: dsba, an escheric ... | 1992 | 1438213 |
| the phototoxicity of 8-methoxythionepsoralen and 6-methylthionecoumarin. | the phototoxicity of 8-methoxythionepsoralen (8-motp) and 6-methylthione coumarin (6-mtc) when activated by uv-a has been investigated using a variety of escherichia coli strains, haemophilus influenzae transforming dna and escherichia coli pbr322 plasmid dna. the results demonstrate that 8-motp is a strictly oxygen independent photosensitizer that is about 500-fold less efficient in forming lesions leading to equivalent lethality than is the parent compound from which it is derived (8-mop). as ... | 1992 | 1438569 |
| [epidemiology of micro-organisms responsible for community-acquired pneumonia]. | pneumonias occupy a prominent situation among lower respiratory tract infections where they are remarkable for their potential mortality and for our relative knowledge of the responsible micro-organisms. analysis and synthesis of each series published must answer several questions, such as: what are the lung diseases considered? which investigations have been performed? which criteria of imputability have been used? in which patients has the study been carried out? in which place, which period a ... | 1992 | 1439460 |
| [models of experimental haemophilus influenzae and streptococcus pneumoniae pneumonia in mice]. | streptococcus pneumoniae and haemophilus influenzae are the bacteria most frequently involved in bronchopulmonary and e.n.t. diseases. experimental models are useful to analyse in vivo the physiopathological interactions between bacteria and lung tissue and to study the activity of various antibiotics in the focus of infection. models for pneumococci are devised according to the virulence of the strain, the inoculation technique and the type of animal used. when strains of different virulence an ... | 1992 | 1439468 |
| cerebral infarction as a remote complication of childhood haemophilus influenzae meningitis. | | 1992 | 1441481 |
| permeability of the normal round window membrane to haemophilus influenzae type b endotoxin. | sensorineural hearing loss associated with otitis media may be due to passage of ototoxic substances such as bacterial toxins and antibiotics, from the middle ear into the inner ear. the round window membrane is the most likely route for such transport. the aim of this study was to analyze the extent of endotoxin passage through the normal round window membrane. the round window membranes of 19 chinchillas were exposed in vivo to gelfoam soaked in purified haemophilus influenzae type b endotoxin ... | 1992 | 1441995 |
| nasopharyngeal bacterial flora in otitis prone children treated with immunoglobulin. | the present study was undertaken to evaluate possible beneficial effects of regularly given, long term immunoglobulin prophylaxis of children below 2 years of age with recurrent acute otitis media (raom). the nasopharyngeal bacterial flora and the frequency of acute otitis media (aom) and secretory otitis media som were studied. every second of 44 children with 3 or more periods of aom during the last year received immunoglobulin intramuscularly (gammaglobulin kabi 165 mg/l, 0.45 ml/kg b.w.) eve ... | 1992 | 1441996 |
| utility of serum interleukin-6 for diagnosis of invasive bacterial disease in children. | to evaluate measurement of interleukin-6 as a diagnostic test for the presence and severity of invasive bacterial disease. | 1992 | 1443833 |
| effect of beta-lactams on peptidoglycan metabolism of haemophilus influenzae grown in animals. | we have examined bacterial determinants that influence beta-lactam activity in haemophilus influenzae cells cultivated in a system that reproduces in vivo growth conditions. bacteria grown in diffusion chambers were recovered from the peritoneal cavities of rats, and their cell properties were compared with those of bacteria grown in broth cultures by various tests performed in vitro. the rate of peptidoglycan synthesis was measured as the incorporation of [14c]alanine into cell wall material in ... | 1992 | 1444294 |
| high incidence rates of invasive pneumococcal disease in the white mountain apache population. | in this article we determine the incidence and clinical spectrum of invasive pneumococcal disease in the white mountain apache population, a group known to have a high incidence of invasive disease due to haemophilus influenzae type b. | 1992 | 1444688 |
| purulent otitis media in adults. | while the bacterial origin of otitis media has been studied extensively in children, there are few data regarding adults with this disease. we undertook this study to identify the incidence, prevalence, and bacteriologic origin of purulent otitis media in adults. this was accomplished through a review of the english-language literature on adult otitis media and a retrospective review of adult patients with this disease who were hospitalized at our institution. results of literature review indica ... | 1992 | 1444690 |
| beta-lactam resistance in gram-negative bacteria: global trends and clinical impact. | microbial drug resistance is an inescapable consequence of the utilization of antimicrobial agents in a given environment. nowhere is the importance of resistance more evident than among agents of the beta-lactam family. trends toward increased resistance can be seen among fastidious gram-negative bacteria like haemophilus influenzae, where ampicillin resistance varies from 1% to 64% globally. for escherichia coli, ampicillin resistance has risen to > or = 50% in high-risk populations, and resis ... | 1992 | 1445981 |
| synthesis and biological activities of optical isomers of 2-(4-diphenylmethyl-1-piperazinyl)ethyl 5-(4,6-dimethyl-2-oxo-1,3,2-dioxaphosphorinan-2-yl)-1,4-dihydro-2,6-dim ethyl-4-(3-nitrophenyl)-3-pyridinecarboxylate dihydrochloride (nip-101). | six optical isomers of 2-(4-diphenylmethyl-1-piperazinyl)ethyl 5-(4,6-dimethyl-2-oxo-1,3,2-dioxaphosphorinan-2-yl)-1,4-dihydro-2, 6-dimethyl-4-(3-nitrophenyl)-3-pyridinecarboxylate dihydrochloride (nip-101, 1.2hcl.2h2o), a potent calcium antagonist, were successfully prepared by using optically active (2r,4r)-(-)- and (2s,4s)-(+)-2,4-pentanediols, and cis-2,4-pentanediol and optically active (s)-(+)-2-methoxy-2-phenylethanol. their proton nuclear magnetic resonance investigations demonstrate tha ... | 1992 | 1446357 |
| [a line of chinese hamster cells containing human chromosome 18]. | | 1992 | 1446812 |
| developmental changes in sequential activation of laryngeal abductor muscle and diaphragm in infants. | in animals and human adults, upper airway muscle activity usually precedes inspiratory diaphragm activity. we examined the interaction of the posterior cricoarytenoid muscle (pca), which abducts the larynx, and the diaphragm (dia) in the control of airflow in newborn infants to assess the effect of maturation on respiratory muscle sequence. we recorded tidal volume, airflow, and dia and pca electromyograms (emg) in 12 full-term, 14 premature, and 10 premature infants with apnea treated with amin ... | 1992 | 1447088 |
| cloning and sequencing of a gene encoding a 21-kilodalton outer membrane protein from bordetella avium and expression of the gene in salmonella typhimurium. | three gene libraries of bordetella avium 197 dna were prepared in escherichia coli le392 by using the cosmid vectors pcp13 and pya2329, a derivative of pcp13 specifying spectinomycin resistance. the cosmid libraries were screened with convalescent-phase anti-b. avium turkey sera and polyclonal rabbit antisera against b. avium 197 outer membrane proteins. one e. coli recombinant clone produced a 56-kda protein which reacted with convalescent-phase serum from a turkey infected with b. avium 197. i ... | 1992 | 1447140 |
| transvaginal gamete intra-fallopian transfer and embryo intra-fallopian transfer. | this study describes the conduct and results of a recently developed technique for transvaginal catheterization of the fallopian tube in order to transfer gametes or early embryos. transvaginal gamete intra-fallopian transfer (tv-gift) was performed in 46 patients after stimulation with human menopausal gonadotrophin (hmg) and human chorionic gonadotrophin (hcg) and transvaginal oocyte retrieval. this resulted in 11 (23.9%) pregnancies. eight patients delivered healthy children, including one se ... | 1992 | 1447363 |
| licensure of "new generation" conjugated haemophilus influenzae type b vaccines. | | 1992 | 1448014 |
| multiple in vivo footprints are specific to the active allele of the x-linked human hypoxanthine phosphoribosyltransferase gene 5' region: implications for x chromosome inactivation. | dosage compensation of x-linked genes in male and female mammals is accomplished by random inactivation of one x chromosome in each female somatic cell. as a result, a transcriptionally active allele and a transcriptionally inactive allele of most x-linked genes reside within each female nucleus. to examine the mechanism responsible for maintaining this unique system of differential gene expression, we have analyzed the differential binding of regulatory proteins to the 5' region of the human hy ... | 1992 | 1448069 |
| functional localization and lateralization of human olfactory cortex. | anatomical and physiological investigations in monkeys indicate that olfaction is subserved by several cortical regions. but the areas implicated in the human olfactory system have not been definitively identified by functional criteria. behavioural evidence has suggested that laterally specialized mechanisms for odour processing may exist, but the neuroanatomical substrate remains unknown. we used positron emission tomography to study the cortical representation of human olfactory processing by ... | 1992 | 1448149 |
| comparative efficacy of oral rifampin and topical chloramphenicol in eradicating conjunctival carriage of haemophilus influenzae biogroup aegyptius. brazilian purpuric fever study group. | persistent conjunctival carriage of the haemophilus influenzae biogroup aegyptius (hae) strain (bpf clone) responsible for brazilian purpuric fever (bpf) has been documented. topical chloramphenicol is routinely used to treat conjunctivitis in areas affected by bpf in brazil. although the bpf clone is susceptible to chloramphenicol, we observed a number of children treated with topical chloramphenicol for conjunctivitis who still developed bpf. during an investigation of an outbreak of bpf in ma ... | 1992 | 1448311 |
| haemophilus influenzae type b endocarditis and meningitis. | | 1992 | 1448325 |
| decline of haemophilus disease in cleveland. | | 1992 | 1448329 |
| expectant antibiotic therapy in an infant already immunized against hemophilus influenzae type b. | | 1992 | 1448331 |
| [bacterial adhesion to epithelial cells of the nasopharynx essential in the development of otitis media]. | otitis media develops when certain bacterial pathogens gain access to the middle ear cavity from the nasopharynx through the eustachian tube. adhesion of bacteria, in particular streptococcus pneumoniae and haemophilus influenzae, to the non-ciliated epithelial cells of the nasopharynx, close to the opening of the eustachian tube, is significantly correlated to the otitis-prone condition in children. otitis-prone children have significantly fewer bacteria in the nasopharynx coated with the immun ... | 1992 | 1448342 |
| ethionine: a new antileukaemic drug? | in our hands, benzene proved to be a valuable drug for the treatment of chronic leukaemia. when correctly administered it did not provoke the harmful side effects reported by several authors in accord with the first description of von koranyi in 1912. in many cases benzene induced complete remission persisting for over 18 months. this compound was found to be active even in patients who had not responded to busulphan, although the contrary was also observed for certain subjects. in accordance wi ... | 1992 | 1448355 |
| differentiation of human thyroid follicle cells from normal subjects and basedow's disease in three-dimensional collagen gel culture. | thyroid follicles, an essential functional unit of the thyroid, exist in the extracellular matrix of the tissue in vivo. therefore, in any monolayer culture system, the follicles cannot be reconstructed. our previous study adopting three-dimensional collagen gel culture showed that isolated porcine follicle cells reconstructed thyroid follicles specific for the thyroid gland in vivo. to elucidate whether this culture system is also applicable to human follicle cells, and furthermore to provide a ... | 1992 | 1448378 |
| [characteristics of the dynamics of hematopoietic precursor cells cloned in diffusion chambers and recorded in experiments on mice and dogs irradiated in median lethal doses]. | in experiments with mice and dogs irradiated with ld50, it was shown the postirradiation depopulation of haemopoietic polypotent (cfus) cell-precursors in mouse bone marrow was more pronounced than that of granulocytic and macrophagal cells (cfudc). the rate of repopulation of cfus during the first week was higher than that of cfudc (t1/2 was 2.5 and 8.8 days respectively). in dogs, one could notice a partial change in the colony formation, a prolonged plateau period in the postirradiation cfudc ... | 1992 | 1448562 |
| dot-elisa for detection of phenolic glycolipid pgl-tb1 and diacyl-trehalose antigens of mycobacterium tuberculosis. | a dot-elisa method for detection of 2,3-diacyl-trehalose (dat, previously referred to as sl-iv antigen) and triglycosyl phenol phthiocerol di-mycocerosate (pgl-tb1) antigens from mycobacterium tuberculosis is described. the method enabled the detection of both antigens in 14 clinical isolates of m. tuberculosis from different geographic origins; the presence of the glycolipids was confirmed by chemical analysis. it was therefore concluded that the synthesis of both of these compounds is characte ... | 1992 | 1448617 |
| the bacterial phosphotransferase system as a potential vehicle for the entry of novel antibiotics. | during the past twenty-nine years, not a single class of antimicrobial agents has been discovered that has led to new approved human drugs. despite a dramatic increase in the potency of existing classes, the need for new effective antimicrobial agents continues. the bacterial phosphotransferase system (pts) offers the possibility of providing new opportunities for the discovery of important agents. this system offers a vehicle for entry into infecting bacteria and pathways for the initiation of ... | 1992 | 1448620 |
| [non-hodgkin's lymphoma and aids: histopathologic features]. | hiv-related non-hodgkin lymphomas currently occur in 5 to 8% of aids patients. aids-related lymphomas are high-grade tumors with the morphologic characteristics of either small noncleaved cell lymphomas of the burkitt type or large cell centroblastic and immunoblastic lymphomas. mixed features may be found, making classification difficult. useful methods for characterizing aids-related non-hodgkin's lymphomas include immunophenotypic studies using b-cell differentiation and activation antigens ( ... | 1992 | 1449258 |
| [vaccination against haemophilus influenzae b and rubella]. | haemophilus influenzae b was the most frequent pathogen of bacterial meningitis in childhood during the mid-eighties to the end of the eighties of the present century, taking the place of meningococci since approximately 1984 at about twice the rate of that pathogen, as shown by the records kept during 1980-1990 in bavarian departments of paediatrics. in fact, in 1990 the incidence of hib meningitides was about 2.5 times that of meningococcus meningitides (85 vs. 34, respectively). for practical ... | 1992 | 1450535 |
| antibacterial profile of flurithromycin, a new macrolide. | the in-vitro activity of flurithromycin against common respiratory tract gram-positive (85 strains) and gram-negative (44 strains) pathogens, and a collection of anaerobes (125 strains) was compared with that of erythromycin, cefixime, amoxycillin, co-amoxiclav, ciprofloxacin, netilmicin and clindamycin. flurithromycin possessed the same spectrum and potency of antimicrobial activity as erythromycin. the presence of 50% human serum in the test media enhanced the activity of flurithromycin agains ... | 1992 | 1452490 |
| bronchoalveolar distribution of cefuroxime axetil and in-vitro efficacy of observed concentrations against respiratory pathogens. | the concentrations of cefuroxime in human alveolar macrophages (am), epithelial lining fluid (elf), bronchial mucosal biopsies and serum were measured after a single dose, equivalent to 500 mg of cefuroxime base, given in the form of the orally-administered pro-drug, cefuroxime axetil. fourteen patients undergoing fibreoptic bronchoscopy with bronchoalveolar lavage were studied. the mean elf concentration was 0.7 mg/l, that of bronchial biopsies was 1.8 mg/kg and that of serum 3.5 mg/l. am-assoc ... | 1992 | 1452503 |
| in vitro susceptibility testing of haemophilus influenzae: review of new national committee for clinical laboratory standards recommendations. | | 1992 | 1452681 |
| long-term success with the national health objective for influenza vaccination: an institution-wide model. | to assess the long-term effectiveness of an influenza vaccination program. | 1992 | 1453242 |
| additional dose urged for some receiving haemophilus influenzae vaccine in early '90s. | | 1992 | 1453513 |
| invasive haemophilus influenzae infections in men with hiv infection. | to determine the incidence of invasive haemophilus influenzae disease in men with the acquired immunodeficiency syndrome (aids) or human immunodeficiency virus (hiv) infection and the proportion of disease due to serotype b. | 1992 | 1453528 |
| [hemophilus vaccines. at last effective protection]. | | 1992 | 1455136 |
| sequence analysis of the rob-1 beta-lactamase gene from actinobacillus pleuropneumoniae. | the rob-1 beta-lactamase gene from actinobacillus pleuropneumoniae was cloned and sequenced. the structural gene encodes a 305 amino acid polypeptide. the rob-1 beta-lactamase gene sequence is identical to that derived from pasteurella haemolytica and only one amino acid different from that of haemophilus influenzae, suggesting that they are derived from the same ancestor, and transformed from one to another. | 1992 | 1455627 |
| immunological and bacteriological studies on mucosa-associated lymphatic tissue in children with som. | | 1992 | 1456119 |
| evolution of the bacterial flora in recurrent adenotonsillitis. therapeutic implications. | | 1992 | 1456122 |
| bacteriology of tonsils in children: comparison between recurrent acute tonsillitis and tonsillar hypertrophy. | | 1992 | 1456124 |
| role of haemophilus influenzae and group a streptococci in recurrent tonsillar infection or hypertrophy. | | 1992 | 1456131 |
| adenoids and otitis media with effusion in children. | | 1992 | 1456150 |
| [fever and petechial exanthema in children]. | in an attempt to determine clinical and analytical predictive parameters of a possible grave disease, we have carried out a retrospective study of 172 children admitted to our hospital with fever and petechiae as initial symptoms. the ages ranged between 1 month and 10 years. even though we have not found a clinical symptom or analysis sufficiently sensitive as to predict all grave diseases, the general clinical state of the child associated with either a high or low white cell count and an abno ... | 1992 | 1456613 |
| [bacterial epidemiology of acute otitis media]. | since the middle of the 1980's, haemophilus influenzae is the most common bacterial species responsible for acute otitis media in france, followed by streptococcus pneumoniae. haemophilus influenzae has maintained its leading position since 1985, but the rate of pneumococcal acute otitis media is increasing fairly steadily. the other recent change with regard to the distribution of bacterial agents is the emergence, four years later than in north america, of branhamella catarrhalis which current ... | 1992 | 1456675 |
| rapid isolation of flanking genomic dna using biotin-rage, a variation of single-sided polymerase chain reaction. | a method is described for quickly and reproducibly isolating genomic dna contiguous with known dna sequence by means of the polymerase chain reaction (pcr). flanking genomic dna is isolated using a biotinylated sequence-specific primer in combination with a generic hybrid primer that binds to a deoxyoligonucleotide sequence artificially added to the ends of the genomic dna. amplified sequences that include the biotinylated primer are purified from nonbiotinylated amplification products by bindin ... | 1992 | 1457047 |
| if the stimulus to pituitary thyroid-stimulating hormone (tsh) secretion is the lack of circulating free thyroxine (free-t4) why may a baby with congenital nephrotic syndrome present with a raised tsh on neonatal screening? | | 1992 | 1457327 |
| ocular manifestations of systemic diseases. | the diseases included in this article constitute a wide range of maladies that affect the horse. certainly, the diseases that are known today to produce ocular lesions are just a few of what will be discovered if attending veterinarians always examine the eyes of patients with systemic diseases. | 1992 | 1458333 |
| cardioprotective effect of cromakalim (potassium channel opener) in isoproterenol induced myocardial infarction in rats. | animals pretreated with cromakalim (1 mg/kg,po) along with isoproterenol (85 mg/kg,sc) showed less myocardial degenerative changes on histopathological examinations when compared with those treated with isoproterenol alone. cromakalim's beneficial effects on myocardium were in dose-dependent manner. administration of cromakalim (po) lowered significantly the serum ldh and sgot and depleted intracytoplasmic glycogen as demonstrated by periodic schiff staining procedure. increase in blood clotting ... | 1992 | 1459635 |
| cervix tumour cell line established from tumour after long term passages as heterotransplant in nude mice. | one human cancer of the uterine cervix xenograft was established in tissue culture only after repeated passages in nude mice suggesting that with the repeated passages in nude mice, tumour cells acquire some properties which allow them to grow in vitro. attempts to establish cell line tumours from earlier passages were not successful. the established cell line is tumourigenic. on inoculation of cultured cells in nude mice tumour take was found to be 100%. karyotypic analysis revealed human origi ... | 1992 | 1459641 |
| presence of rna from yeast inhibits the photoreactivation of uv-irradiated dna by phr a photolyase from escherichia coli. | photoreactivation of uv-irradiated dsna with phr a photolyase from escherichia coli was studied in the presence of yeast rna. mixing of rna with uv-irradiated dna before its treatment with photolyase inhibited the photoreactivation of dna. denatured (by sonication) rna was found to be more effective in blocking photolyase action. agarose gel electrophoresis experiments suggest that this inhibition of photoreactivation is due to interference in the binding of photolyase with uv-irradiated dna by ... | 1992 | 1459658 |
| effect of haemophilus influenzae polysaccharide outer membrane protein complex conjugate vaccine on macrophages. | haemophilus influenzae type b polysaccharide-conjugate vaccines elicit protective antibody responses in young infants. one of these conjugates, polysaccharide linked to outer membrane protein complex (prp-ompc), is produced by linking the capsular polysaccharide to an outer membrane protein complex derived from group b neisseria meningitidis. the outer membrane protein complex contains t cell carrier epitopes that elicit t cell-dependent antibody responses. ompc also has been shown to increase t ... | 1992 | 1460286 |
| academic achievement following childhood brain disease: implications for the concept of learning disabilities. | the present study examined three hypotheses regarding the consequences of early brain damage for academic achievement: first, early brain insults will have a negative impact on achievement, even in children with normal intelligence. second, underachievement in these children will be at least partially independent of iq (i.e., not fully accounted for by a lowering of iq within the average range). third, normally intelligent children with histories of brain insult will also manifest selective cogn ... | 1992 | 1460384 |
| [study on incidence of haemophilus influenzae type b. factual incidence on a county level confirms earlier nationwide estimations]. | | 1992 | 1460992 |
| [neonatal sepsis caused by haemophilus influenzae in the first few days of life]. | | 1992 | 1461317 |
| type b and non-type b haemophilus influenzae endocarditis. | | 1992 | 1461698 |
| [the potentialities and results of the etiologic diagnosis of acute pneumonias]. | the paper deals with the results of the joint soviet-hungarian study for the determination of etiology of acute pneumonias. study included 617 patients. the bacteriologic and serologic methods were used to reveal the causative agent of the disease. prevalence of streptococcus pneumoniae (33-49%) in the etiologic structure of acute pneumonias was established both in the ussr and hungary. in many cases pneumonia is also caused by haemophilus influenzae (21-22%). in 15-31% of the cases the causativ ... | 1992 | 1461896 |
| three novel mutations in the liver-type arginase gene in three unrelated japanese patients with argininemia. | argininemia is caused by a hereditary deficiency of liver-type arginase (e.c.3.5.3.1) and is characterized by psychomotor retardation and spastic tetraplegia. we examined findings in three japanese patients with argininemia, by using the pcr, cloning, and sequencing procedures. we found three different mutations--g-to-a-365 in exon 4, g-to-c-703 in exon 7, and c-del-842 in exon 8--thereby leading to mutant arginase proteins of w122x, g235r, and l282fs, respectively. patient 1 was a compound hete ... | 1992 | 1463019 |
| add another dose of haemophilus influenzae vaccine. | | 1992 | 1463483 |
| comparison of loracarbef (ly163892) versus amoxicillin in the treatment of bronchopneumonia and lobar pneumonia. | loracarbef (ly163892), a carbacephem, is the first of a new class of beta-lactam compounds. a 14-day, double-blind, randomized, parallel treatment study compared loracarbef (400 mg b.i.d.; n = 169) and amoxicillin (500 mg t.i.d.; n = 167) in the treatment of lobar pneumonia and bronchopneumonia. forty-four patients in the loracarbef group and 40 patients in the amoxicillin group were evaluable for efficacy analysis. streptococcus pneumoniae and haemophilus influenzae were isolated from pure or m ... | 1992 | 1463527 |
| protein profiles of perilymph and endolymph of the guinea pig. | results of protein separation of guinea pig plasma, perilymph, and endolymph by means of high-resolution two-dimensional sodium dodecyl sulfate polyacrylamide gel electrophoresis are presented. several proteins are present in perilymph at levels in basic accord with the total protein gradient with respect to plasma; however, others are present in perilymph at levels comparable to plasma levels, and one protein low molecular weight protein, pls:33, is eight times higher. in addition, a high molec ... | 1992 | 1464573 |
| antibody response to a haemophilus influenzae type b polysaccharide tetanus toxoid conjugate vaccine in splenectomized children and adolescents. | 20 children and adolescents 4-18 years old and splenectomized for various reasons (spherocytosis (n = 6), idiopathic thrombocytopenia (n = 8), other (n = 6)) were immunized once with a haemophilus influenzae type b (hib) polysaccharide tetanus toxoid conjugate vaccine. prior to vaccination 10/20 patients had anticapsular antibodies below what could be considered the minimum protective level in splenectomized (0.6 micrograms/ml), whereas all obtained high antibody levels after vaccination. in add ... | 1992 | 1465581 |
| [the etiological structure of acute bacterial meningitis in different regions]. | in 1985-1989 the etiological structure of acute bacterial meningitides (abm) in children was studied in 4 largest industrial cities in different regions of the european part of the former ussr, as well as in 2 industrial cities of western siberia. due to the common methodological approach used in all investigations, comparable data were obtained in all cities. these investigations revealed that meningococci caused 53.0-86.7% of all cases of abm in children, which corresponded to moderately incre ... | 1992 | 1466162 |
| the epidemiology of acute epiglottitis in children in western australia. | a comprehensive case definition was used to study all cases of epiglottitis that occurred in children under 15 years of age in western australia during a 5 year period. there was microbiological evidence of haemophilus influenzae type b infection in 71% of 103 cases of epiglottitis. seventy-five per cent of cases occurred in children under 5 years of age. in this age group, the estimated annual incidence (13.5 episodes per 100,000) was significantly lower than that reported in victoria (22.7 per ... | 1992 | 1466944 |
| chloramphenicol-resistant haemophilus influenzae meningitis in young urban nigerian children. | in a developing country like nigeria, the unusual emergence of haemophilus influenzae type b, resistant to cost-effective antimicrobials, is of serious concern. we report three cases of h. influenzae type b meningitis in young nigerian children in whom clinical and bacteriological features of resistance to chloramphenicol were identified. one of the cases had concomitant resistance to ampicillin (multiple-drug resistance). significant anaemia was an associated feature in two cases, one of whom h ... | 1992 | 1467621 |
| a changing pattern of epiglottitis. | a case review of epiglottitis at geisinger medical center over the past 12 years demonstrates a decrease in the number of pediatric patients with epiglottitis and an increase in the number of adults with epiglottitis. in the last five years, the number of epiglottitis patients younger than 10 years has fallen (0 cases), while the number of patients over 10 years of age has increased (6 cases). the cause of epiglottitis, hemophilus influenzae type b, remains constant in the pediatric as well as i ... | 1992 | 1468169 |
| hemophilus influenza infection of an implantable insulin-pump pocket. | to increase awareness of adverse events associated with the use of implantable insulin pumps. | 1992 | 1468268 |
| penetration of pefloxacin into maxillary sinus cavity and nasal secretions. | the ability of oral pefloxacin to penetrate into maxillary sinus cavity and nasal secretions was studied in 39 patients suffering from an exacerbation of chronic maxillary sinusitis. the mean levels of pefloxacin in sinus aspirate fluid 0, 3, 6, 9 and 12 h after the second oral dose of 400 mg were 2.30, 6.92, 3.74, 3.47 and 2.82 mg/l respectively. in sinus cystic fluid (macroscopically non-purulent) the mean pefloxacin levels were 2.30, 7.15, 4.20 and 4.15 mg/l respectively, and in nasal secreti ... | 1992 | 1468421 |
| comparative in vitro activity of clarithromycin. spanish collaborative group. | the activity in vitro of clarithromycin, a new macrolide, was compared to that of various antibiotics in tests using 3,880 clinical isolates. clarithromycin was two times more active than erythromycin against staphylococcus aureus, enterococcus faecalis, enterococcus faecium, streptococci of groups c, g and f, brucella melitensis, legionella pneumophila and mycoplasma spp., 16 times more active against ureaplasma urealyticum and 2 to 4 times less active against campylobacter spp. in general, cla ... | 1992 | 1468430 |
| in vitro potency of nine orally administered antimicrobial agents against three respiratory tract pathogens. | | 1992 | 1468431 |
| primary prevention of haemophilus influenzae type b. | routine immunisation of infants against haemophilus influenzae type b (hib) has the potential to prevent up to 1200 cases of serious infection and 60 deaths every year in the united kingdom. sara hodgson reports the findings of a study in the oxford region to determine the safety and immunogenicity of the hib conjugate vaccine prp-t when given to british infants in concurrence with primary immunisations, according to the accelerated schedule of two, three and four months of age. | 1992 | 1468945 |
| hib. educating parents and professionals. | a totally new immunisation (hib) offers protection against the commonest cause of bacterial meningitis in the under fives. judith moreton describes the development and implementation of health education programmes in oxfordshire to achieve a 90 per cent take-up in the first year, even among traveller gypsies, who are recognised as generally having poor immunisation uptake. | 1992 | 1468946 |
| hib. assessing information needs. | planning the launch of the new haemophilus influenzae b vaccine in october of this year has challenged health educators involved with child immunisation, writes christine mcguire of the health education authority (hea). here she outlines the findings from initial research commissioned to explore parental and professional information needs. | 1992 | 1468947 |
| [mrsa in bacterial infections]. | | 1992 | 1469305 |
| research note: failure of hippocampal lesions to influence feed and water intake in the chick. | damage to the hippocampal region has shown varying effects on feed and water intake in rats. three experiments were conducted to determine whether hippocampal ablation influences feed and water intake in the chick. thirteen to 20 chicks in each trial were assigned randomly to lesioned or sham-operated control groups. feed and water intake was monitored for 24 or 48 h following recovery from the surgical procedure. no differences were noted in either parameter measured. the current studies indica ... | 1992 | 1470596 |
| audit of the use of erythromycin in the treatment of community-acquired lower respiratory infections. | the british thoracic society (bts) guidelines for the treatment of community-acquired pneumonia recommend initial therapy with a betalactam antibiotic, with the addition of erythromycin if there are features of an atypical pneumonia. to see if these guidelines were being followed, a prospective study was undertaken of all adult patients admitted to hospital over a 3-month period who were given erythromycin for a community-acquired lower respiratory tract infection. erythromycin was given to 62 p ... | 1992 | 1470708 |
| [treatment of bacterial meningitis in children]. | the treatment of children with bacterial meningitis includes many aspects, such as fluid and antibacterial therapy, treatment of convulsions, and prophylactic use of dexamethasone. this report focuses in particular on the prophylactic use of dexamethasone together with cefalosporines in order to reduce inflammation and neurological sequelae in this disease. probably this approach is now justified in the treatment of meningitis caused by haemophilus influenzae. modern principles for fluid therapy ... | 1992 | 1471132 |
| identification of amino acid changes affecting yeast uroporphyrinogen decarboxylase activity by sequence analysis of hem12 mutant alleles. | the molecular basis of the uroporphyrinogen decarboxylase defect in eleven yeast 'uroporphyric' mutants was investigated. uroporphyrinogen decarboxylase, an enzyme of the haem-biosynthetic pathway, catalyses the decarboxylation of uroporphyrinogen to coproporphyrinogen and is encoded by the hem12 gene in the yeast saccharomyces cerevisiae. the mutations were identified by sequencing the mutant hem12 alleles amplified in vitro from genomic dna extracted from the mutant strains. four mutations lea ... | 1992 | 1471989 |
| the introduction of haemophilus influenzae b (hib) vaccine. | | 1992 | 1473940 |