| association of cytokine responses with disease severity in infants with respiratory syncytial virus infection. | to explore the relationship between cytokine responses and severity of respiratory syncytial virus (rsv) infection in infants. | 2002 | 12412865 |
| recombinant respiratory syncytial virus with the g and f genes shifted to the promoter-proximal positions. | the genome of human respiratory syncytial virus (rsv) encodes 10 mrnas and 11 proteins in the order 3'-ns1-ns2-n-p-m-sh-g-f-m2-1/m2-2-l-5'. the g and f glycoproteins are the major rsv neutralization and protective antigens. it seems likely that a high level of expression of g and f would be desirable for a live rsv vaccine. for mononegaviruses, the gene order is a major factor controlling the level of mrna and protein expression due to the polar gradient of sequential transcription. in order to ... | 2002 | 12414935 |
| immune response to respiratory syncytial virus in young brazilian children. | we have evaluated the cellular and humoral immune response to primary respiratory syncytial virus (rsv) infection in young infants. serum specimens from 65 patients <=12 months of age (39 males and 26 females, 28 cases <3 months and 37 cases > or = 3 months; median 3 3.9 months) were tested for anti-rsv igg and igg subclass antibodies by eia. flow cytometry was used to characterize cell surface markers expressed on peripheral blood mononuclear cells (pbmc) from 29 rsv-infected children. there wa ... | 2002 | 12424491 |
| burden of disease in hospitalized rsv-positive children in germany. | in spite of a large amount of data from other countries, those on the burden of disease attributed to respiratory syncytial virus (rsv) in germany are lacking and are urgently needed. | 2002 | 12424681 |
| [effects of respiratory syncytial virus infection on t-helper cytokines expression in balb/c mice sensitized with ovalbumin]. | to determine the effects of rsv infection on the development of lung inflammation and the expressions of t-helper cell related cytokines in balb/c mice pre-sensitized with ovalbumin. | 2002 | 12425832 |
| clustered charge-to-alanine mutagenesis of human respiratory syncytial virus l polymerase generates temperature-sensitive viruses. | clustered charge-to-alanine mutagenesis was performed on the large (l) polymerase protein of human respiratory syncytial virus to identify charged residues in the l protein that are important for viral rna synthesis and to generate temperature-sensitive viruses. clusters of three, four, and five charged residues throughout the entire l protein were substituted with alanines. a minigenome replicon assay was used to determine the functions of the mutant l proteins and to identify mutations that ca ... | 2002 | 12429529 |
| interleukin-6, interleukin-8, interleukin-11, and interferon-gamma levels in nasopharyngeal aspirates from wheezing children with respiratory syncytial virus or influenza a virus infection. | the differences between respiratory syncytial virus (rsv) and influenza a virus (ifav) in the pathogenesis of wheezing in young children have not been clearly defined. the aim of this study was to assess the contributions of rsv vs ifav in the pathogenesis of upper airway inflammation in wheezy young children. we compared interleukin (il)-6, il-8, il-11, and interferon-gamma (ifn-gamma) levels in nasopharyngeal aspirates (npa) from non-asthmatic children with respiratory virus infections (rsv in ... | 2002 | 12431194 |
| simultaneous detection of influenza a, b, and c viruses, respiratory syncytial virus, and adenoviruses in clinical samples by multiplex reverse transcription nested-pcr assay. | the clinical presentation of infections caused by the heterogeneous group of the respiratory viruses can be very similar. thus, the implementation of virological assays that rapidly identify the most important viruses involved is of great interest. a new multiplex reverse transcription nested-polymerase chain reaction (rt-pcr) assay that is able to detect and type different respiratory viruses simultaneously is described. primer sets were targeted to conserved regions of nucleoprotein genes of t ... | 2003 | 12436489 |
| respiratory syncytial virus enhances respiratory allergy in mice despite the inhibitory effect of virus-induced interferon-gamma. | in mice, respiratory syncytial virus (rsv) infection during allergic provocation aggravates the allergic th2 immune response, characterised by production of interleukin (il)-4, il-5, and il-13, and eosinophilic inflammation. this enhancement of the th2 response occurs simultaneously with a strong rsv-induced th1 cytokine response (il-12 and ifn-gamma). the present study investigated whether ifn-gamma and il-12 are critically involved in this rsv-enhanced ova allergy. therefore, ifn-gammar- and i ... | 2003 | 12436492 |
| parental emotional and time costs predict compliance with respiratory syncytial virus prophylaxis. | two agents are effective in preventing respiratory syncytial virus (rsv) hospitalization in premature infants: rsv immune globulin (rsv-ig) and palivizumab. rsv-ig is associated with greater parental emotional and time costs, which may account for the more limited adherence to recommended monthly treatment with this agent. | 2002 | 12437390 |
| age at first viral infection determines the pattern of t cell-mediated disease during reinfection in adulthood. | infants experiencing severe respiratory syncytial virus (rsv) bronchiolitis have an increased frequency of wheeze and asthma in later childhood. since most severe rsv infections occur between the 8th and 24th postnatal week, we examined whether age at first infection determines the balance of cytokine production and lung pathology during subsequent rechallenge. primary rsv infection in newborn mice followed the same viral kinetics as in adults but was associated with reduced and delayed ifn-gamm ... | 2002 | 12438429 |
| retrovirus-specific packaging of aminoacyl-trna synthetases with cognate primer trnas. | the trnas used to prime reverse transcription in human immunodeficiency virus type 1 (hiv-1), rous sarcoma virus (rsv), and moloney murine leukemia virus (mo-mulv) are, trna(trp), and trna(pro), respectively. using antibodies to the three cognate human aminoacyl-trna synthetases, we found that only lysyl-trna synthetase (lysrs) is present in hiv-1, only tryptophanyl-trna synthetase (trprs) is present in rsv, and neither these two synthetases nor prolyl-trna synthetase (prors) is present in mo-mu ... | 2002 | 12438642 |
| impact and cost-effectiveness of respiratory syncytial virus prophylaxis for kansas medicaid's high-risk children. | to determine the impact of prophylactic therapy for respiratory syncytial virus (rsv) infections on subsequent hospitalizations and related lengths of stay and costs and to estimate whether prophylactic treatment was cost-effective. | 2002 | 12444839 |
| polysulfonates derived from metal thiolate complexes as inhibitors of hiv-1 and various other enveloped viruses in vitro. | sodium 2-mercaptoethanesulfonate reacts with the metal ions pd(ii), pt(ii), ag(i), cd(ii) and zn(ii) to yield complexes containing multiple anionic sulfonate sites. on the basis of spectroscopic and other analytical data the complexes were assigned the tentative molecular formulas: pd6(sch2ch2so3na)12, ptn(sch2ch2so3na)2n+2, agn(sch2ch2so3na)n, na2zn4(sch2ch2so3na)10, and na2cd4(sch2ch2so3na)10. the complexes displayed a variety of differences in activity towards dna and rna viruses. the platinu ... | 2002 | 12448691 |
| rsv bronchiolitis and risk of wheeze and allergic sensitisation in the first year of life. | severe respiratory syncytial virus (rsv) infection has been hypothesised to be a risk factor for the development of allergy and asthma, but epidemiological studies in older children have been inconclusive. the current study hypothesises that the effect of rsv bronchiolitis might be most prominent during the first year after bronchiolitis. forty-two infants had experienced rsv bronchiolitis severe enough to cause hospitalisation. for each child with rsv infection, two controls were acquired from ... | 2002 | 12449185 |
| surfactant proteins as genetic determinants of multifactorial pulmonary diseases. | surfactant proteins, sp-a, sp-b, sp-c and sp-d, play important roles in pulmonary surfactant function and metabolism. sp-a and sp-d, being members of the collectin family of proteins, also interact with pathogens and are involved in pulmonary host defense. respiratory diseases are among the most common causes of death worldwide. several life-threatening lung diseases, such as neonatal respiratory distress syndrome (rds) and acute ros (ards), are associated with impaired surfactant function. alle ... | 2002 | 12452477 |
| characteristics of immunity induced by viral antigen or conferred by antibody via different administration routes. | the characteristics of the immunity induced by viral antigens or conferred by antiviral antibody via different routes of administration were evaluated comparatively. c57bl/6 mice were immunized via intranasal, intradermal or enteric routes with a live recombinant vaccinia virus expressing the respiratory syncytial virus (rsv) f glycoprotein (f.rvv) or rsv, and then challenged intranasally with rsv. inhibition of rsv replication was observed in the lungs of all the mice; however, only intranasal ... | 2002 | 12452827 |
| replication of respiratory syncytial virus is inhibited in target cells generating nitric oxide in situ. | nitric oxide (no) is generated by recruited inflammatory cells and by pulmonary epithelial cells in response to respiratory virus infection, although the relative antiviral efficacy of no from each of these sources had not been clarified. to compare the direct, antiviral potency of no from an exogenous source with that generated by target epithelial cells in situ, we transduced hep-2 epithelial cells with the retroviral construct, pmfgs-nos and cloned transductant lines that generated no constit ... | 2003 | 12456366 |
| acute viral bronchiolitis and its sequelae in developing countries. | acute viral bronchiolitis (avb) is a common disease found throughout the world. various aspects of it are being studied: its epidemiology, diagnosis, prognosis and treatment. most of these studies are being conducted in developed countries, with only a few taking place in developing countries. risk factors such as poor nutrition, an adverse environment and early weaning should be studied where these features are common. treatment aspects such as cost-effectiveness in low income settings need fur ... | 2002 | 12457599 |
| use of a vesicular stomatitis virus complementation system to analyze respiratory syncytial virus binding. | respiratory syncytial virus (rsv) can be difficult to manipulate in the laboratory because it produces a fragile, filamentous virion that does not bud efficiently from the cell surface and which is sensitive to purification. these properties have complicated the studies of rsv envelope protein-host cell interactions. in this paper, we have tested the ability of the rsv attachment protein, g, to complement virus attachment of a recombinant vesicular stomatitis virus (vsvdeltag*), which lacks any ... | 2002 | 12457986 |
| extracorporeal membrane oxygenation for pneumonitis after a glenn palliation. | a five-month old male with a single ventricle palliated with a bidirectional cavopulmonary anastomosis developed severe respiratory insufficiency from respiratory syncytial virus (rsv) pneumonitis. he was successfully rescued with extracorporeal membrane oxygenation (ecmo) therapy and recovered with minimal morbidity. | 2002 | 12470038 |
| specificity of plasma membrane targeting by the rous sarcoma virus gag protein. | budding of c-type retroviruses begins when the viral gag polyprotein is directed to the plasma membrane by an n-terminal membrane-binding (m) domain. while dispersed basic amino acids within the m domain are critical for stable membrane association and consequent particle assembly, additional residues or motifs may be required for specific plasma membrane targeting and binding. we have identified an assembly-defective rous sarcoma virus (rsv) gag mutant that retains significant membrane affinity ... | 2003 | 12477852 |
| short report: seasonal pattern of respiratory syncytial virus in a region with a tropical climate in southeastern brazil. | among acute respiratory infections (aris), respiratory syncytial virus (rsv) is an important pathogen, especially in infants and preschool children. this study focused on rsv epidemiology in a region of southeastern brazil with a tropical climate. a total of 406 nasopharyngeal secretion samples were taken from children less than five years of age with aris. of these, 114 (28%) were rsv-positive. these samples were found in all age groups, but showed a higher prevalence in newborns. infection wit ... | 2002 | 12479549 |
| passive transfer of serum antibodies induced by bbg2na, a subunit vaccine, in the elderly protects scid mouse lungs against respiratory syncytial virus challenge. | respiratory syncytial virus (rsv) is responsible for severe low respiratory tract infections in young infants and the elderly. to investigate whether bbg2na, a recombinant subunit vaccine comprising aa 130-230 of the rsv g protein, induced protective abs in subjects over 60 years during phase ii clinical trial, pre- and postimmunization sera of individuals immunized with bbg2na or placebo were transferred into scid mice before rsv challenge. these sera dose-dependently reduced lung rsv titers. h ... | 2002 | 12482664 |
| relationships among specific viral pathogens, virus-induced interleukin-8, and respiratory symptoms in infancy. | both virus-mediated damage to airway tissues and induction of pro-inflammatory cytokines such as interleukin-8 (il-8) could contribute to symptom severity during viral respiratory infections in children. to test the hypothesis that il-8 contributes to the pathogenesis of respiratory symptoms during naturally acquired respiratory viral infections in children, nasal wash samples collected from infants with acute viral infections (n = 198) or from healthy uninfected infants (n = 31) were analysed f ... | 2002 | 12485313 |
| wheezing requiring hospitalization in early childhood: predictive factors for asthma in a six-year follow-up. | although asthma is common after wheezing in early childhood, the risk factors for and the prevention of later asthma are poorly understood. during the present follow-up study, a range of possible predictive factors for school-age asthma was evaluated. the study group consisted of 82 children hospitalized for wheezing at age < 2 years in 1992-93. the baseline data were collected on entry to the study. in 1999, the children were re-examined at the median age of 7.2 years. a structured questionnair ... | 2002 | 12485317 |
| detection of rice grassy stunt tenuivirus nonstructural proteins p2, p5 and p6 from infected rice plants and from viruliferous brown planthoppers. | the genome of rice grassy stunt virus (rgsv) consists of 6 ambisense rna segments, among which rnas 1, 2, 5 and 6 are equivalent to rnas 1, 2, 3 and 4, respectively, of rice stripe virus, the type species of the genus tenuivirus. the rgsv 36-kda nucleocapsid protein (n) is encoded on the complementary strand of rna 5. here, we studied accumulation of three nonstructural proteins, a 23-kda p2 protein encoded on vrna 2 (virus genomic strand), a 22-kda p5 protein encoded on vrna 5, and a 21-kda p6 ... | 2002 | 12491098 |
| influenza-related hospitalizations among children in hong kong. | it has been difficult to define the burden of influenza in children because of confounding by the cocirculation of respiratory syncytial virus (rsv). in hong kong, china, the influenza and rsv infection seasons sometimes do not overlap, thus providing an opportunity to estimate the rate of influenza-related hospitalization in a defined population, free from the effects of rsv. | 2002 | 12501221 |
| identification of immunodominant epitopes derived from the respiratory syncytial virus fusion protein that are recognized by human cd4 t cells. | memory cd4 t-cell responses against respiratory syncytial virus (rsv) were evaluated in peripheral blood mononuclear cells of healthy blood donors with gamma interferon enzyme-linked immunospot (elispot) assays. rsv-specific responses were detected in every donor at levels varying between 0.05 and 0.3% of cd4 t cells. for all donors tested, a considerable component of the cd4 t-cell response was directed against the fusion (f) protein of rsv. we characterized a set of 31 immunodominant antigenic ... | 2003 | 12502814 |
| altered pathogenesis of severe pneumovirus infection in response to combined antiviral and specific immunomodulatory agents. | we report here the responses of mice with symptomatic pneumovirus infection to combined antiviral and specific immunomodulatory agents. mice infected with pneumonia virus of mice, a natural mouse pathogen that replicates the signs and symptoms of severe infection with respiratory syncytial virus (rsv), responded to the antiviral agent ribavirin when it was administered in the setting of endogenous (gene deletion) or exogenous (antibody-mediated) blockade of the mip-1alpha proinflammatory signali ... | 2003 | 12502841 |
| cytokine expression in respiratory syncytial virus-infected mice as measured by quantitative reverse-transcriptase pcr. | in the murine model for respiratory syncytial virus (rsv) infection, cytokine patterns induced by vaccinations with either killed (i.e. formalin-inactivated, alum-precipitated) virus (kv) or live virus (lv) have been shown to influence disease expression. to determine the mrna expression of the cytokines il-4 and ifn-gamma in balb/c mice challenged with rsv, a real-time quantitative reverse-transcriptase pcr assay was developed. this assay uses 5'-exonuclease fluorogenic probes and is performed ... | 2003 | 12505627 |
| aetiology and outcome of severe community-acquired pneumonia in children admitted to a paediatric intensive care unit. | to determine the aetiological agents and outcome of severe community-acquired pneumonia (scap) in children admitted to the paediatric intensive care unit (picu) at kalafong hospital, pretoria. | 2002 | 12506595 |
| cytokine gene polymorphisms moderate responses to respiratory syncytial virus in adults. | immune responses and illness severity during viral upper respiratory infections may be influenced by the local elaboration of cytokines. cytokine gene polymorphisms moderate immune responses and severity of illness in various inflammatory and infectious diseases. we performed cytokine genotyping on 29 adults experimentally inoculated with respiratory syncytial virus (rsv) to determine whether specific cytokine gene polymorphisms are associated with immune responses or illness severity. dna was e ... | 2003 | 12507818 |
| association of severe respiratory syncytial virus bronchiolitis with interleukin-4 and interleukin-4 receptor alpha polymorphisms. | the association of variants of genes encoding interleukin (il)-4 and the il-4 receptor alpha chain (il-4ralpha) with respiratory syncytial virus (rsv) bronchiolitis was examined in hospitalized infants. polymorphisms in il-4 (c-590t) and il-4ralpha (i50v and q551r) were genotyped by restriction fragment-length polymorphism analysis. control subjects included parents of the hospitalized children (for the transmission/disequilibrium test), and a random population sample (for the case-control study ... | 2003 | 12508140 |
| respiratory viruses in exacerbations of chronic obstructive pulmonary disease requiring hospitalisation: a case-control study. | acute exacerbations of chronic obstructive pulmonary disease (ae-copd) are a common cause of hospital admission. many exacerbations are believed to be due to upper and/or lower respiratory tract viral infections, but the incidence of these infections in patients with copd is still undetermined. | 2003 | 12511718 |
| mortality associated with influenza and respiratory syncytial virus in the united states. | influenza and respiratory syncytial virus (rsv) cause substantial morbidity and mortality. statistical methods used to estimate deaths in the united states attributable to influenza have not accounted for rsv circulation. | 2003 | 12517228 |
| simultaneous detection, subgrouping, and quantitation of respiratory syncytial virus a and b by real-time pcr. | timely diagnosis of respiratory syncytial virus (rsv) infection is critical for appropriate treatment of lower respiratory infection in young children. to facilitate diagnosis, we developed a rapid, specific, and sensitive taqman pcr method for detection of rsv a and rsv b. two sets of primer-probe pairs were selected from the nucleotide sequences encoding the nucleocapsid protein--one targeting rsv a and the other targeting rsv b. the specificity of the taqman reverse transcription-pcr assay wa ... | 2003 | 12517840 |
| [sequence analysis of rna3 of rice stripe virus isolates found in china: evidence for reassortment in tenuivirus]. | the rna3 segments of four isolates of rice stripe virus (rsv), isolated from endemic sites at panjin (pj), liaoning province, kunming (km) and yiliang (yl), yunnan province, as well as from outbreak sites at hongze (hz), jiangsu province, were determined. rna3 of these four isolates were 2480 bp, 2509 bp, 2489 bp and 2497 bp in length, respectively. compared with rna3 of t and m isolates from japan and y isolate from yunnan province of china, that had been previously reported, these seven isolat ... | 2003 | 12518236 |
| interferon-gamma levels in nasopharyngeal secretions of infants with respiratory syncytial virus and other respiratory viral infections. | respiratory syncytial virus (rsv) infection, one of the most common causes of hospitalization of children in developed countries, has been implicated as a cause of asthma. we aimed to characterize the cytokine profile in nasopharyngeal aspirates (npas) taken from infants during upper respiratory tract infection to investigate whether rsv induced a unique immune response as compared with other viruses. additionally, we sought to determine whether this profile was influenced by the infants' atopic ... | 2003 | 12519398 |
| [respiratory syncytial virus]. | respiratory syncytial virus (rsv) is the most common pathogen of the lower respiratory tract in infants. groups at risk for severe disease include preterm infants, infants with pulmonary disease such as bronchopulmonary dysplasia, infants with congenital heart disease, and infants suffering from immunodeficiency. however, most infants getting severely ill from rsv are otherwise healthy and born at term. the incidence of hospitalisation caused by rsv is increasing, and there is an association bet ... | 2002 | 12523006 |
| [prevalence and structure of acute respiratory virus infections]. | information on epidemiology of acute respiratory virus infections (arvi) is reviewed and analyzed. in addition to influenza viruses, the role of respiratory syncytial viruses (rsv), rhino- and adenoviruses, as well as other viruses, in the development of respiratory diseases, especially in newborns, young children and elderly persons, is emphasized. a high proportion of rsv in the etiology the severe forms of arvi and in the development of intrauterine infection is pointed out. the conclusion ha ... | 2002 | 12525011 |
| role of plasma membrane lipid microdomains in respiratory syncytial virus filament formation. | the fusion protein (f) of respiratory syncytial virus (rsv) is the envelope glycoprotein responsible for the characteristic cytopathology of syncytium formation. rsv has been shown to bud from selective areas of the plasma membrane as pleomorphic virions, including both filamentous and round particles. with immunofluorescent microscopy, we demonstrated evidence of rsv filaments incorporating the fusion protein f and colocalizing with a lipid microdomain-specific fluorescent dye, 1,1-dihexadecyl- ... | 2003 | 12525608 |
| role of viruses and atypical bacteria in exacerbations of asthma in hospitalized children: a prospective study in the nord-pas de calais region (france). | we studied the role of viruses and atypical bacteria in children hospitalized with exacerbated asthma by a prospective study of children with acute asthma admitted to the department of pediatrics in lille, and to 15 hospitals in the nord-pas de calais region, from october 1, 1998-june 30, 1999. we included children aged 2-16 years with active asthma, defined as three or more recurrent episodes of reversible wheezing. the severity of asthma and of asthmatic exacerbations was recorded. immunofluor ... | 2003 | 12526066 |
| [experimental study of the virus inhibitory effect of chuan-kang-ping granule]. | to explore the virus inhibitory effect of chuan-kang-ping granule. | 2001 | 12526312 |
| effect of respiratory syncytial virus infection during early infancy on the ontogeny of cytokine immune responses. | recently, childhood asthma has been associated with an alarming rise in prevalence, morbidity, and mortality. strong epidemiological evidence now links the development of childhood asthma with the persistence of t-helper lymphocyte type 2 (th2) cytokine immune responses during early infancy. however, the ontogeny of human cytokine immune responses and the environmental factors influencing their development have not been fully elucidated. several lines of evidence support the hypothesis that resp ... | 2002 | 12528606 |
| infection of murine precision cut lung slices (pcls) with respiratory syncytial virus (rsv) and chlamydophila pneumoniae using the krumdieck technique. | the krumdieck technique allows the investigation of the so-called precision cut lung slices (pcls) with a special microtome. it is thus possible to evaluate morphologic changes over a longer period of time using only a small group of animals. chlamydophila pneumoniae (cp) and respiratory syncytial virus (rsv) proved to be important causes of pneumonia, rhinitis and exacerbations of asthma bronchiale, as well as of lower respiratory tract infections in young children. pcls should be tested for th ... | 2002 | 12530578 |
| basic epidemiology and immunopathology of rsv in children. | respiratory syncytial virus (rsv) is the most important cause of lower respiratory tract infection in infants and young children. around 20 000 rsv-infected infants require hospitalization in the uk during each yearly epidemic, which is about 3% of the birth cohort. most children are infected by 2 years of age. risk factors for severe disease include young infants, prematurity, chronic lung and cardiac conditions or immunodeficiency. humoral immunity is incomplete and short-lived, yet reinfectio ... | 2000 | 12531081 |
| long-term consequences of respiratory syncytial virus (rsv) bronchiolitis. | despite differences in study design, follow-up studies consistently show that approximately half of the infants with respiratory syncytial virus (rsv) lower respiratory tract infection (lrti) go on to have recurrent wheezing episodes during childhood. respiratory symptoms are associated with abnormal lung function, including bronchial hyper-responsiveness. wheezing symptoms following rsv lrti gradually decrease, and it appears that during school age airway morbidity is no longer related to rsv l ... | 2000 | 12531083 |
| [practical evaluation of rapid diagnostic tests for mycobacteriosis and virus infection]. | because cultures of mycobacteria and viruses take a great number of days, the results are delayed in these clinical laboratory tests. for this reason, rapid diagnostic tests without these cultures are required. among the laboratory tests of mycobacteria, acid-fast stain as a rapid diagnostic test is the first to give significant information to laboratory staffs and physicians. there are mainly two procedures, directly smearing clinical specimens and smearing concentrated specimens treated with n ... | 2002 | 12542395 |
| [sequence analysis of ran4 of a severe isolate of rice stripe virus in china]. | rna4 segment of a severe isolate of rice stripe virus, isolated from liaoning province and designated as pj isolate, was amplified, cloned and sequenced. rna4 of pj isolate had 2157 nucleotide in length. when compared with rna4 of t and m isolates of japan and cx isolate of yunnan province of china that had been previously reported, we found that these four isolates could be divided into two groups. pj, t and m isolates shared 97.0% and 97.0%-97.5% identities in vorf4 and vcofr4 at the nucleotid ... | 2001 | 12549184 |
| respiratory syncytial virus-associated lower respiratory tract infection in under-5-year-old children in a rural community of central thailand, a population-based study. | the population-based cohort study on the epidemiology of respiratory syncytial virus (rsv)-associated lower respiratory tract infection (lri) (rsv-lri) was conducted in takhli district from november 1998 to february 2001. the incidence of rsv-lri was 12.6/1,000 child-year and 5.8/ 1,000 child-year during the first and second year, respectively. rsv accounted for 35.8 per cent of all lri cases during the first year and significantly decreased to 17.5 per cent during the second year. three-quarter ... | 2002 | 12549784 |
| acute viral lower respiratory infections in children in a rural community in thailand. | the present study was conducted as a population based cohort in a rural community of amphoe takhli, nakhon sawan province for the determination of the prevalence of acute viral lower respiratory infection (alri) in pediatric cases under 5 years of age from november 1998 to february 2001. there were 472 alri episodes during the study period; and there were 5 cases who contracted alri twice. the etiologic agents were determined by indirect immunofluorescence (iif) test using specific monoclonal an ... | 2002 | 12549791 |
| wheezing--associated lower respiratory infections in under 5-year-old children: study in takhli district hospital. | wheezing was detected in 251 of the 421 (59.6%) children under 5 years old suffering from acute lower respiratory infections (lri) treated at the takhli hospital, nakhon sawan province from november 1998 to october 2000. bronchitis and pneumonia accounted for 55.0 per cent and 40.6 per cent of lri with wheezing. most of the patients, 162 of 251 (64.5%) cases were children under 2 years old. the wheezing symptom declined significantly in children older than 4 years of age. in this study, lri with ... | 2002 | 12549802 |
| [cloning and sequencing of cdna from g protein gene of subgroup b respiratory syncytial virus strain isolated in china]. | the nucleotide sequence of the g protein gene of respiratory syncytial virus (rsv) cc169 strain isolated from china that has been identified as subgroup b with monoclonal antibodies, was determined from cdna that had been amplified by rt-pcr and cloned into ptz18r plasmid vector. the homology of nucleotide was 94% as compared with g protein cdna of a rsv prototype strain (ch18537). deduced amino acid identity of g protein was 89.4%. the amino acid changes were only in the extracellular part of t ... | 1999 | 12555397 |
| [cloning and sequencing analysis of rice stripe virus genome segment 4 of chinese isolate y]. | the cdna fragment covering full-length sequence of rstv rna4 of yunnan isolate in china was obtained by rt-pcr. the pcr-derived fragment was then cloned into vector pcrii. the cloned cdna was sequenced. comparison of the nucleotide and deduced amino acid sequences with those of the japanese isolate t was made. the results showed that at the nucleotides level, vorf, vcorf and the intergenic region had 94.9%, 94.1% and 86.1% identity respectively, the 5'-untranslational region was exactly the same ... | 1999 | 12555399 |
| rantes (ccl5) production during primary respiratory syncytial virus infection exacerbates airway disease. | respiratory syncytial virus (rsv) is a respiratory pathogen that causes significant morbidity in infants and young children. the importance of chemokines during rsv infection for respiratory symptoms has not been fully elucidated. the current study examined the effect of rantes (ccl5) on airway pathophysiology after rsv infection. balb/c mice produce rantes (ccl5) after rsv infection that correlates with the changes in pathophysiology. animals treated with anti-rantes (ccl5) antibody demonstrate ... | 2002 | 12555673 |
| the incidence of influenza-associated hospitalizations in children in germany. | since new vaccines and anti-viral drugs for influenza have become available, collation of actual and country-specific epidemiological data is essential. since respiratory syncytial virus (rsv) is a well known paediatric airway pathogen and some epidemiological data exist already, a comparison between influenza and rsv seems warranted. from july 1996 to june 2001 the naso-pharyngeal aspirates (npa) of children from birth to 16 years of age, admitted to one of the two paediatric hospitals in kiel, ... | 2002 | 12558335 |
| respiratory syncytial virus infection suppresses ifn-gamma production of gammadelta t cells. | the immunological mechanisms by which respiratory syncytial virus (rsv) contributes to the development of asthma are poorly understood. gammadelta t cells are important in mucosal defence, and may contribute to the establishment of primary immune responses by producing cytokines early during respiratory infections. thus, we used flow cytometry and intracellular cytokine staining to investigate the expression of interferon (ifn)-gamma and interleukin (il)-4 by mitogen-stimulated gammadelta t cell ... | 2003 | 12562394 |
| regional delivery and selective expression of a high-activity yeast cytosine deaminase in an intrahepatic colon cancer model. | a major potential limitation to the success of enzyme prodrug gene therapy is the toxicity that could result from gene expression in normal tissues. in this study, we investigated the use of an enhanced human carcinoembryonic antigen (cea) promoter for yeast cytosine deaminase (ycd), which converts 5-fluorocytosine to 5-fluorouracil, to increase targeting while maintaining activity both in cell culture and in nude rats bearing intrahepatic xenografts. we found that an enhanced cea-ycd adenoviral ... | 2003 | 12566311 |
| il-13 is sufficient for respiratory syncytial virus g glycoprotein-induced eosinophilia after respiratory syncytial virus challenge. | although well studied in settings of helminth infection and allergen sensitization, the combined contributions of il-4 and il-13 and their signaling pathways in models of viral pathogenesis have not been reported. using a murine model of respiratory syncytial virus (rsv) infection, we evaluated the contribution of il-13, alone and in conjunction with il-4, during immunization with recombinant vaccinia virus expressing rsv g glycoprotein (vvgs) or with formalin-inactivated rsv (fi-rsv). we showed ... | 2003 | 12574374 |
| clinical patterns and natural history of asthma. | childhood asthma typically begins in infancy with a respiratory syncytial virus (rsv) infection. although the majority of infants become infected with rsv, lower respiratory illness develops in only about 20%. about 25% to 50% of those subsequently experience recurrent acute asthma from viral respiratory infections (vri). children younger than 5 years have a high frequency of vri and have the highest frequency of hospitalization for asthma of any age group. in a 35-year study of the natural hist ... | 2003 | 12584515 |
| kinetics of v-src-induced epithelial-mesenchymal transition in developing glandular stomach. | the oncogene function in primary epithelial cells is largely unclear. recombination organ cultures in combination with the stable and transient gene transfer techniques by retrovirus and electroporation, respectively, enable us to transfer oncogenes specifically into primary epithelial cells of the developing avian glandular stomach (proventriculus). in this system, the epithelium and mesenchyme are mutually dependent on each other for their growth and differentiation. we report here that either ... | 2003 | 12584568 |
| incidence and clinical features of hospitalization because of respiratory syncytial virus lower respiratory illness among children less than two years of age in a rural asian setting. | lower respiratory illness is the leading cause of child death in the developing world. despite this few reports on respiratory syncytial virus (rsv) lower respiratory illness disease burden exist from rural areas of the developing world, and none exist for indonesia. | 2003 | 12586979 |
| cytokine gene polymorphisms moderate illness severity in infants with respiratory syncytial virus infection. | illness severity and frequency of complications in infants with respiratory syncytial virus (rsv) infection may be influenced by the local elaboration of cytokines. cytokine gene polymorphisms moderate severity of illness in various inflammatory and infectious diseases. we performed cytokine genotyping on 77 infants hospitalized with confirmed rsv infection to determine whether specific cytokine gene polymorphisms are associated with illness severity or complications. dna was extracted from bucc ... | 2003 | 12590978 |
| antibody response after rsv infection in children younger than 1 year of age living in a rural area of mozambique. | serological responses have been studied in respiratory syncytial virus (rsv) infected children < 1 year of age attending the outpatient department of the manhiça district hospital (mozambique). molecular characterization of viral rna in nasopharyngeal aspirates from the infected children indicated a high level of genetic uniformity among the infecting viruses, all of which belonged to a single genotype of rsv group a. a representative virus strain, moz00, was isolated from one of the infants and ... | 2003 | 12601767 |
| evaluation of the safety of palivizumab in the second season of exposure in young children at risk for severe respiratory syncytial virus infection. | palivizumab reduces respiratory syncytial virus (rsv) hospitalisations in high-risk infants. those with severe bronchopulmonary dysplasia may require two seasons of prophylaxis. there is concern that this humanised antibody might cause an adverse immune response in a second season of use. | 2003 | 12608889 |
| mrna instability in the nucleus due to a novel open reading frame element is a major determinant of the narrow tissue specificity of folate receptor alpha. | the folate receptor type alpha (fr-alpha) is a promising tumor marker and target. here, we investigate the mechanistic basis for the tumor specificity and vast overexpression of fr-alpha. among representative fr-alpha-positive (hela and jar) and fr-alpha-negative (mg63, caki1, and ht3) cell lines, the transcription rates of the endogenous fr-alpha gene, as well as the fr-alpha promoter activity, were relatively weak and comparable, but the fr-alpha transcript was abundant only in total rna and n ... | 2003 | 12612090 |
| current strategies in the prevention of respiratory syncytial virus disease. | infants infected with respiratory syncytial virus (rsv) develop both upper and lower respiratory tract infections resulting in laryngotracheobronchitis, bronchiolitis and pneumonia. premature infants of less than 32 weeks' gestation and those with underlying chronic lung disease are particularly susceptible and incur significant morbidity and mortality following hospitalisation. conservative rsv prevention strategies focus on the interruption of transmission by proper hand-washing techniques and ... | 2003 | 12615029 |
| nasal delivery of chitosan-dna plasmid expressing epitopes of respiratory syncytial virus (rsv) induces protective ctl responses in balb/c mice. | respiratory syncytial virus (rsv), an important pathogen of the lower respiratory tract, is responsible for severe illness both in new born and young children and in elderly people. due to complications associated with the use of the early developed vaccines, there is still a need for an effective vaccine against rsv. most pathogens enter the body via mucosal surfaces and therefore vaccine delivery via routes such as the nasal, may well prove to be superior in inducing protective immune response ... | 2003 | 12615444 |
| induced liver tumour further support to a genetic marker with its high correlation with chorioallantoic membrane phenotypes in selected layer lines. | the conventional chorioallantoic membrane (cam) phenotype assay was conducted using 11-day-old embryonatic eggs of white leghorn strains, each inoculated with 0.2 ml of subgroup a rous sarcoma virus (rsv) and subgroup c rsv separately containing 10(3)pfu ml(-1). eggs were further incubated for hatching. harvesting of cams for counting of pocks and monitoring chicks for liver tumour (lt) mortality during 4 weeks of post-hatching period were followed. the conversely associated phenotype (cap) inci ... | 2002 | 12622176 |
| cxcr2 regulates respiratory syncytial virus-induced airway hyperreactivity and mucus overproduction. | severe inflammation and mucus overproduction are partially responsible for respiratory syncytial virus (rsv)-induced disease in infants. using a murine model, we characterized the virally induced chemokine receptors responsible for mediating the pathophysiological response to rsv infection, we found that cxcr2 mrna was induced at 4 days after rsv infection. immunohistochemical staining demonstrated that cxcr2 protein was expressed on alveolar macrophages. immunoneutralization of cxcr2 resulted i ... | 2003 | 12626595 |
| gene therapy for prostate cancer: toxicological profile of four hsv-tk transducing adenoviral vectors regulated by different promoters. | adenoviral vector delivery of the herpes simplex virus thymidine kinase (hsv-tk) gene in combination with the prodrug ganciclovir (gcv) has been tested in phase i clinical trials for prostate cancer and found to exhibit a satisfactory toxicity profile. we have developed additional adenoviral vectors with differing promoters to optimize the expression profile and in the present study evaluate the potential systemic toxicity of these vectors. four recombinant adenoviral vectors that express the hs ... | 2002 | 12627218 |
| quality control assessment of influenza and rsv testing in europe: 2000-01 season. | the quality control assessment (qca) was initiated to evaluate the quality of the influenza and respiratory syncytial virus (rsv) testing in the national reference centres belonging to the european influenza surveillance scheme (eiss) network. samples were coded and sent in two panels of 12 samples within a two week interval to 16 laboratories during the 2000-01 winter season. the antibodies titration by hi test was reported by 60% of the laboratories (n=16), and the results were correct for 56% ... | 2002 | 12631989 |
| use of induced sputum for the diagnosis of influenza and infections in asthma: a comparison of diagnostic techniques. | influenza (flu) and respiratory syncytial virus (rsv) are important viral pathogens that cause lower respiratory tract infections and severe exacerbations of asthma. molecular biological techniques are permitting a rapid and accurate diagnosis of infections caused by respiratory pathogens, and have typically been applied to upper respiratory samples. sputum induction provides an opportunity to directly sample secretions from the lower respiratory tract. objectives/study design: to determine the ... | 2003 | 12637083 |
| immunization onto shaved skin with a bacterial enterotoxin adjuvant protects mice against respiratory syncytial virus (rsv). | this study evaluated the potential of the skin as a non invasive route for rsv vaccination using two g protein-derived molecules, g2na and g5 in mice. g2na contains t and b-cell epitopes whether g5 is a pure b-cell epitope. in contrast to g5, g2na coadministered with ct three times at 1 month interval onto 1cm of square area shaved skin, elicited a consistent serum anti-g2na and anti-ct igg response. the anti-g2na igg response was dominated by igg1 isotype, an indirect marker of a th2 type of re ... | 2003 | 12639488 |
| immunomodulatory effects of sensory nerves during respiratory syncytial virus infection in rats. | respiratory syncytial virus (rsv) infection is associated with exaggerated neurogenic inflammation in the airways. this study sought to determine whether irritation of the mucosal sensory fibers affects the recruitment of lymphocytes and monocytes to rsv-infected airways. pathogen-free rats were inoculated with rsv or with virus-free medium and were injected 5 days later with capsaicin to stimulate airway sensory nerves. bronchoalveolar lavage was performed 1, 5, or 10 days after nerve stimulati ... | 2003 | 12639840 |
| time and out-of-pocket costs associated with respiratory syncytial virus hospitalization of infants. | the objective of this study was to quantify time spent plus out-of-pocket costs associated with confirmed respiratory syncytial virus (rsv) hospitalization of infants not prophylaxed against rsv. | 2003 | 12641860 |
| distribution of the attachment (g) glycoprotein and gm1 within the envelope of mature respiratory syncytial virus filaments revealed using field emission scanning electron microscopy. | field emission scanning electron microscopy (fe sem) was used to visualize the distribution of virus-associated components, the virus-attachment (g) protein, and the host-cell-derived lipid, gm1, in respiratory syncytial virus (rsv) filaments. rsv-infected cells were labeled in situ with a g protein antibody (mab30) whose presence was detected using a second antibody conjugated to colloidal gold. no bound mab30 was detected in mock-infected cells, whereas significant quantities bound to viral fi ... | 2003 | 12642099 |
| incidence and risk factors of respiratory syncytial virus-related hospitalizations in premature infants in germany. | premature infants have an increased risk of developing complicated respiratory syncytial virus (rsv) infections. epidemiological data on rsv-related hospitalizations are a prerequisite to develop guidelines for the use of preventive measures. the objective of this study was to determine incidence and risk factors of rsv-related rehospitalizations (rsv-rh) of premature infants. we recruited 1,103 infants with a gestational age of less than 35 weeks, primarily admitted to nine neonatologic care un ... | 2003 | 12647195 |
| economic evaluation of possible prevention of rsv-related hospitalizations in premature infants in germany. | palivizumab (synagis, medimmune inc./abbott laboratories) has been shown to reduce the number of respiratory syncytial virus (rsv)-related hospitalizations in premature infants. the cost-effectiveness ratio of this prophylaxis, however, has not been evaluated in the german health-care system to date. the aim of the study was to assess the costs and benefits of palivizumab among premature infants </=35 weeks with different risk factors. projecting a societal perspective, we used decision analysis ... | 2003 | 12647196 |
| isolation and characterisation of potential respiratory syncytial virus receptor(s) on epithelial cells. | respiratory syncytial virus (rsv) infection causes severe lower respiratory diseases in infancy, early childhood and the elderly. rsv infections respond poorly to current therapies. therefore, we initiated a search for novel drug targets by investigating the characteristics and identity of rsv adhesion receptors on mammalian cells. soluble human lectins, complex polysaccharides and a low molecular selectin antagonist, tbc1269, were used to characterise and isolate the rsv receptor on a human epi ... | 2003 | 12650770 |
| [is respiratory syncytial virus one of the causative agents for transient hyperphosphatasemia?]. | in the winter of 2001, we found several cases of transient hyperphosphatasemia (th) in patients with respiratory syncytial virus (rsv) infection. therefore, we tried to verify that rsv was one of the causative agents for th. | 2002 | 12652683 |
| increased aeroallergen-specific interleukin-4-producing t cells in asthmatic adults. | asthma, atopy and some forms of respiratory syncytial virus (rsv) disease are thought to be caused by t cells making il-4 (th2 cells). however, not all patients with similar patterns of clinical disease have the same underlying pathogenesis and the ability to detect immunopathogenic t cells by examination of the peripheral blood remains in doubt. with the prospect of specific immunotherapy for diseases caused by t cell subsets, it is important to determine whether peripheral blood mononuclear ce ... | 2002 | 12653165 |
| increased susceptibility to rsv infection by exposure to inhaled diesel engine emissions. | although epidemiologic data strongly suggest a role for inhaled environmental pollutants in modulating the susceptibility to respiratory infection in humans, the underlying cellular and molecular mechanisms have not been well studied in experimental systems. the current study assessed the impact of inhaled diesel engine emissions (dee) on the host response in vivo to a common pediatric respiratory pathogen, respiratory syncytial virus (rsv). using a relatively resistant mouse model of rsv infect ... | 2003 | 12654634 |
| ultrafine carbon black particles enhance respiratory syncytial virus-induced airway reactivity, pulmonary inflammation, and chemokine expression. | exposure to particulate matter (pm) may exacerbate preexisting respiratory diseases such as asthma, chronic obstructive pulmonary disease (copd), bronchitis, and pneumonia. however, few experimental studies have addressed the effects of pm on lower respiratory tract (lrt) viral infection. respiratory syncytial virus (rsv) is a major etiological agent for lrt infections in infants, the elderly, and the immunocompromised and may lead to chronic wheezing and the development of asthma in children. i ... | 2003 | 12655033 |
| effect of preexposure to ultrafine carbon black on respiratory syncytial virus infection in mice. | epidemiological studies have indicated that exposure to elevated levels of particulate matter exacerbates several pulmonary diseases, including asthma, bronchitis, and viral infections. respiratory syncytial virus (rsv) is the major cause of bronchiolitis and pneumonia in infants and may lead to the development of asthma in childhood. to determine whether particle exposure modulates the immune response to rsv, eight-week-old female balb/c mice received an intratracheal (i.t.) instillation of eit ... | 2003 | 12660365 |
| respiratory syncytial virus (rsv) fusion protein subunit f2, not attachment protein g, determines the specificity of rsv infection. | human respiratory syncytial virus (hrsv) and bovine rsv (brsv) infect human beings and cattle in a species-specific manner. we have here analyzed the contribution of rsv envelope proteins to species-specific entry into cells. in contrast to permanent cell lines, primary cells of human or bovine origin, including differentiated respiratory epithelia, peripheral blood lymphocytes, and macrophages, showed a pronounced species-specific permissiveness for hrsv and brsv infection, respectively. recomb ... | 2003 | 12663767 |
| [experimental study on effect of recombined decoction on mumps virus]. | to evaluate possible inactivating effect of recombined decoction in on mumps virus. | 2002 | 12665939 |
| identification of a novel human leucocyte antigen-a*01-restricted cytotoxic t-lymphocyte epitope in the respiratory syncytial virus fusion protein. | virus-specific cytotoxic t lymphocytes (ctl) play a major role in the clearance of respiratory syncytial virus (rsv) infection. to begin monitoring the immunological response to infection, especially in infants, it is important to identify human leucocyte antigen (hla)-restricted ctl epitopes. herein, we used a novel, comprehensive peptide panel containing all possible 8-, 9- and 10-mer peptides spanning the rsv fusion protein to screen for novel hla-restricted t-cell epitopes. these peptide set ... | 2003 | 12667209 |
| systematic review of the biology and medical management of respiratory syncytial virus infection. | respiratory syncytial virus, the leading cause of serious upper and lower respiratory tract infection in infants and children, accounts for 125,000 hospitalizations and 450 deaths annually in the united states. it also may predispose to development of asthma later in life. annual epidemics occur from november to april, and virtually all infants are infected by age 2. immunity is not durable; hence, reinfection occurs throughout life, although subsequent infections are nearly always mild. certain ... | 2003 | 12667273 |
| investigations into the amino-terminal domain of the respiratory syncytial virus nucleocapsid protein reveal elements important for nucleocapsid formation and interaction with the phosphoprotein. | bacterially expressed nucleocapsid (n) protein, from respiratory syncytial virus (rsv), was used to investigate rna binding in a modified north-western blotting protocol. the recombinant protein demonstrated no sequence specificity in binding rna representing either the antigenomic leader sequence or the nonspecific sequence derived from a plasmid vector. when recombinant n was purified on cscl gradients, two types of structure, both with densities indicating that they contained rna, could be vi ... | 2003 | 12667822 |
| distinct patterns of gene transfer to gerbil hippocampus with recombinant adeno-associated virus type 2 and 5. | genetic modification of the gerbil hippocampal neuronal cells in vivo helps us understand the mechanisms of neuronal function under various circumstances such as ischemic insult. in this study, we examined the distinct distribution of the recombinant adeno-associated virus type 2 (raav2) and raav5 vectors for gene delivery to primary cultured cells and the gerbil hippocampus. mixed cortical cultures containing both neurons and astrocytes from e17 rat embryos were infected with raavs containing t ... | 2003 | 12668259 |
| quantitation of respiratory syncytial virus rna in nasal aspirates of children by real-time rt-pcr assay. | a method was developed for the quantitation of respiratory syncytial virus (rsv) based on real-time rt-pcr using a lightcycler instrument. a control real-time rt-pcr was undertaken on gapdh mrna (a human housekeeping gene) was carried out to standardise the non-homogeneous respiratory samples. the real-time rt-pcr method was one log more sensitive for the detection of rsv according to the endpoint dilution technique than the culture method or a conventional qualitative rt-pcr-hybridization-eia. ... | 2003 | 12668266 |
| respiratory syncytial virus and other respiratory viruses. | respiratory syncytial virus (rsv), a nonsegmented, single stranded rna virus, infects one-half of all infants within the first year of life. rsv possesses pathogenetic qualities that may be attributed to the interplay of viral and host-specific factors including virus strains of different virulence, size of the inoculum, family history of asthma or airway hyperreactivity and immunologic anomalies of the host. inflammatory cell recruitment and activation occur in response to rsv infection of epit ... | 2003 | 12671447 |
| impact of severe disease caused by respiratory syncytial virus in children living in developed countries. | among industrialized nations, the rate of rehospitalization in the united states for respiratory syncytial virus (rsv) is approximately 30 per 1000, exceptions being noted for american indians and alaskan natives, two ethnic groups who tend toward higher rates of rsv hospitalization. in distinction japan reports an admission rate of 60 per 1000 for rsv disease. yet japan ranks considerably lower than many of its western counterparts in premature births. whether an rsv subtype, a new viral genoty ... | 2003 | 12671448 |
| respiratory syncytial virus epidemics: the ups and downs of a seasonal virus. | respiratory syncytial virus (rsv) is the most common pathogen causing lower respiratory tract infections in infants worldwide. lower respiratory tract infections caused by rsv occur epidemically, and the appearance of epidemics seems to vary with latitude, altitude and climate. this study uses a review of the literature on rsv seasonality to investigate whether a global pattern in rsv epidemics can be found. a comparison of morbidity and mortality caused by rsv in developed vs. developing countr ... | 2003 | 12671449 |
| selected populations at increased risk from respiratory syncytial virus infection. | respiratory syncytial virus (rsv) is the principal cause of bronchiolitis and pneumonia in infants and young children worldwide. deficits in cellular immunity appear to promote severe rsv disease in children with malignancies, those undergoing chemotherapy and bone marrow transplant recipients. respiratory syncytial virus infection appears to exacerbate pulmonary symptoms of cystic fibrosis. in such patients rsv disease may result in a prolonged hospital course, which is often complicated by the ... | 2003 | 12671451 |
| palivizumab prophylaxis of respiratory syncytial virus disease from 1998 to 2002: results from four years of palivizumab usage. | objectives: in 1998 the food and drug administration approved palivizumab (synagis) for the prevention of severe lower respiratory tract infection secondary to respiratory syncytial virus (rsv) in pediatric patients at high risk for developing disease that required hospitalization. in the immediate aftermath of that approval, two retrospective reviews were conducted on 4669 medical records of patients who received at least 1 dose of palivizumab during the 1998 to 1999 and 1999 to 2000 rsv season ... | 2003 | 12671452 |
| palivizumab outcomes registry data from spain: infección respiratoria infantil por virus respiratorio sincitial (iris) study group. | respiratory syncytial virus (rsv) is the leading cause of lower respiratory illness in children <2 years of age. severe rsv infection requiring hospitalization is linked to gestational age, chronic cardiopulmonary conditions and immunosuppression. the infección respiratoria infantil por virus respiratorio sincitial (iris) study group in spain conducted two pivotal epidemiologic studies establishing that serious rsv illness among premature infants was responsible for high rehospitalization rates ... | 2003 | 12671453 |
| links between respiratory syncytial virus bronchiolitis and childhood asthma: clinical and research approaches. | this review examines the relationship between severe pulmonary disease caused by respiratory syncytial virus (rsv) infection in infancy and later development of asthma or reactive airway disease (rad). rsv infection accounts for 70% or greater of all cases of infantile bronchiolitis and has been linked to subsequent asthma or rad, either directly or through a shared common predisposition. several studies suggest that rsv bronchiolitis is an important factor in the development of asthma and possi ... | 2003 | 12671454 |