| An investigation on different harvesting methods on young pods of KKU # 922 maize (Zea mays L.) cultivar for baby corn production. | This study aimed to search for the best indicator to be used for the harvest of maize pods for baby corn production. A Randomized Complete Block Design (RCBD) with four replications was used. The treatments are: T1 (Control) Taking sample when silks of female flower had extended from tip of pod up to 3 cm long T2, silks had extended 1 cm long T3, silks had extended 2 cm long T4, blooming of female flower for 2 days T5, blooming of female flowers for 4 days T6, blooming of female flower for 6 day ... | 2011 | 21902059 |
| Outcome of T4 (International Union Against Cancer Staging System, 7th edition) or Recurrent Nasal Cavity and Paranasal Sinus Carcinoma Treated with Proton Beam. | PURPOSE: To investigate the clinical features, prognostic factors, and toxicity of treatment for unresectable carcinomas of the nasal cavity and paranasal sinus (NCPS) treated with proton beam therapy (PBT). METHODS AND MATERIALS: Seventeen patients (13 men, 4 women) with unresectable carcinomas of the NCPS who underwent PBT at the University of Tsukuba between 2001 and 2007 were analyzed. The patients' median age was 62 years (range, 30-83 years). The tumors were located in the nasal cavity in ... | 2011 | 22099036 |
| Idiopathic spinal cord herniation at two separate zones of the thoracic spine: the first reported case and literature review. | Idiopathic spinal cord herniation (ISCH) is a rare cause of progressive myelopathy. Preoperative diagnosis can be made with magnetic resonance imaging (MRI). Many surgical techniques have been applied by various authors, and ISCH is usually reversible by surgical treatment. | 2011 | 21862417 |
| Does the baricity of bupivacaine influence intrathecal spread in the prolonged sitting position before elective cesarean delivery? A prospective randomized controlled study. | Difficulties in inserting an epidural catheter while performing combined spinal-epidural anesthesia for cesarean delivery may lead to undue delays between the spinal injection of the local anesthetic mixture and the adoption of the supine position with lateral tilt. We hypothesized that this delay may affect the intrathecal distribution of local anesthetic of different baricities such that hypobaric local anesthetic would lead to a higher sensory block level. | 2011 | 21890887 |
| target highlights in casp9: experimental target structures for the critical assessment of techniques for protein structure prediction. | one goal of the casp community wide experiment on the critical assessment of techniques for protein structure prediction is to identify the current state of the art in protein structure prediction and modeling. a fundamental principle of casp is blind prediction on a set of relevant protein targets, that is, the participating computational methods are tested on a common set of experimental target proteins, for which the experimental structures are not known at the time of modeling. therefore, th ... | 2011 | 22020785 |
| ct thoracic duct lymphography in cats by popliteal lymph node iohexol injection. | three different doses (1.0, 1.5, and 2.0 ml) of iohexol (300 mgi/ml) were injected percutaneously into the popliteal lymph node of eight adult cats under ultrasound guidance. serial transverse ct images of five regions of interest (l3, t13, t8, t4, and t1 level) were performed at 2-min intervals, and the attenuation in hounsfield units (hu) of the lymphatic vessels was measured for determination of the optimal dose of iohexol and ct scan parameters. the optimal dose was 1.5 ml and helical ct acq ... | 2011 | 22136199 |
| Dynamics of mutator and antibiotic-resistant populations in a pharmacokinetic/pharmacodynamic model of Pseudomonas aeruginosa biofilm treatment. | Biofilm growth, antibiotic resistance, and mutator phenotypes are key components of chronic respiratory infections by Pseudomonas aeruginosa in cystic fibrosis patients. We examined the dynamics of mutator and antibiotic-resistant populations in P. aeruginosa flow-cell biofilms, using fluorescently tagged PAO1 and PAOMS (mutator [mutS] derivative) strains. Two-day-old biofilms were treated with ciprofloxacin (CIP) for 4 days (t4) at 2 µg/ml, which correlated with the mutant prevention concentrat ... | 2011 | 21859941 |
| individualised isotoxic accelerated radiotherapy and chemotherapy are associated with improved long-term survival of patients with stage iii nsclc: a prospective population-based study. | background: individualised, isotoxic, accelerated radiotherapy (indar) allows the delivery of high biological radiation doses, but the long-term survival associated with this approach is unknown. methods: patients with stage iii nsclc in the netherlands cancer registry/limburg from january 1, 2002 to december 31, 2008 were included. results: patients (1002) with stage iii nsclc were diagnosed, of which 938 had t4 and/or n2-n3 disease. patients treated with curative intent were staged with fdg-pe ... | 2011 | 22100659 |
| immediate effects of a thoracic spine thrust manipulation on the autonomic nervous system: a randomized clinical trial. | thoracic spine manipulation has been shown to be effective for the management of neck pain. the purpose of this study was to investigate the immediate effect of a t3-t4 spinal thrust manipulation on autonomic nervous system activity in subjects with chronic cervical pain. an additional aim was to determine if the manipulation resulted in an immediate pain relief in patients with chronic neck pain when compared to a placebo intervention. one hundred subjects with chronic neck pain were randomly a ... | 2010 | 22131791 |
| [results of preoperative chemoradiotherapy for t4 rectal cancer]. | we reviewed clinical records of 11 cases with preoperative chemoradiotherapy to evaluate the clinical effectiveness of chemoradiotherapy for t4 rectal cancer. the preoperative radiotherapy consisted of 40-50 gy delivered in fractions of 1 .8- 2.0 gy per day, five days per week. a treatment of 5-fluorouracil, 500 mg/body per day intravenously, or oral uft-e (300 mg/m2) with l-leucovorin (75 mg) per day, or oral s-1 (80 mg/m2) per day five days per week, was given during radiotherapy. one patient ... | 2011 | 22202339 |
| transient changes in thyroid functions tests after zoledronic acid infusion. | zoledronic acid (za) induces an acute phase response in association with elevation of serum cytokines, which possibly alter the 3 types of iodothyronine deiodinase activity. we therefore studied the possible alteration in thyroid function tests by za. we investigated the acute changes in serum thyroid hormones, tsh, cortisol, white blood cells, crp, interleukin-6 (il-6) and tumor necrosis factor (tnf-α), before (0) and 1, 2 and 3 days after iv infusion of 5 mg za in 24 asymptomatic postmenopau ... | 2011 | 21891972 |
| Assembling linear DNA templates for in vitro transcription and translation. | Cell-free expression systems provide straightforward access from genes to the corresponding proteins, involving fewer handling steps than in vivo procedures. A quick procedure to assemble a gene of interest into a linear DNA template together with 3'- and 5'-untranslated regions using a coupled uracil-excision-ligation strategy based on USER Enzyme and T4 DNA ligase. This methodology will be useful for repeated cycles of expression and in vitro selection, in which gene libraries are repeatedly a ... | 2012 | 22130984 |
| Sex Differences in Spinal Osteoarthritis in Humans and Rhesus Monkeys (Macaca mulatta). | STRUCTURED ABSTRACT.: Study Design. Retrospective study of male and female spinal osteoarthritis, characterized by lateral spine thoracolumbar radiographs, in humans and nonhuman primatesObjective. To characterize differences in prevalence and vertebral distribution of spinal osteoarthritis between men and women, between male and female macaques, and between the two phylogenetically related genera.Summary of Background Data. Naturally occurring spinal osteoarthritis manifests similarly in humans ... | 2011 | 22024896 |
| Impact of low-level thyroid hormone disruption induced by propylthiouracil on brain development and function. | The critical role of thyroid hormone (TH) in brain development is well-established. Evidence shows that severe deficiencies lead to significant neurological dysfunction. Much less information is available on more modest perturbations of TH on brain function. The present study induced varying degrees of developmental hypothyroidism by administration of low doses of the TH synthesis inhibitor, propylthiouracil (PTU 0, 1, 2, and 3 ppm) to the drinking water of pregnant rats. This regimen produced d ... | 2011 | 21964421 |
| retrospective computed tomography scan analysis of percutaneously inserted pedicle screws for posterior transpedicular stabilisation of the thoracic and lumbar spine: accuracy and complication rates. | structured abstract: study design. retrospective clinical data analysis.objective. to investigate the misplacement rate and related clinical complications of percutaneous pedicle screw insertion in the thoracic and lumbar spine.summary of background data. percutaneous insertion of cannulated pedicle screws has been developed as a minimally invasive alternative to the open technique during instrumented fusion procedures of the thoraco-lumbar spine. the reported rate of screw misplacement using op ... | 2011 | 22037528 |
| current surgical treatment of non-small-cell lung cancer. | when considering surgical treatment for non-small-cell lung cancer (nsclc), a distinction is made between early-stage disease (stages ia/b and iia/b), locoregionally advanced disease (stages iiia/b) and metastatic disease (stage iv). complete surgical resection of nsclc can provide good long-term outcome. surgery is considered the treatment of choice in patients with early-stage nsclc or patients with t3n1 disease. surgery for locoregionally advanced disease remains controversial. in specific ca ... | 2011 | 21999131 |
| Docetaxel plus 5-fluorouracil and cisplatin (DCF) induction chemotherapy for locally advanced borderline-resectable T4 esophageal cancer. | This study aimed to evaluate the efficacy of docetaxel plus 5-fluorouracil and cisplatin (DCF) induction chemotherapy for locally advanced borderline-resectable T4 esophageal cancer. | 2011 | 21965775 |
| Lymph node dissection in renal cell carcinoma. | Although lymphadenectomy (lymph node dissection [LND]) is currently accepted as the most accurate and reliable staging procedure for the detection of lymph node invasion (LNI), its therapeutic benefit in renal cell carcinoma (RCC) still remains controversial. | 2011 | 21940096 |
| Subclinical hypothyroidism in pregnancy: intellectual development of offspring. | The effects of maternal subclinical hypothyroidism (M-SCH) on the neuropsychological development of the offspring are not clear. We evaluated the intellectual development of children of mothers who had M-SCH during the pregnancy for these children. | 2011 | 21943136 |
| Risk for progression to overt hypothyroidism in an elderly Japanese population with subclinical hypothyroidism. | Few population-based studies report the changes with time in thyroid function tests in patients with subclinical hypothyroidism. We compared the risk for developing overt hypothyroidism in patients with subclinical hypothyroidism and euthyroid controls from the same population of elderly Japanese. We also sought associations of selected parameters with the development of overt hypothyroidism in the subclinical hypothyroid and euthyroid groups. | 2011 | 21877935 |
| effect of selenium, zinc, and copper supplementation on blood metabolic profile in male buffalo (bubalus bubalis) calves. | twenty male buffalo calves (15 months, 200.2 ± 9.75) were divided into four groups of five animals in each and fed diets without (t1) or supplemented with 0.3 ppm selenium (se) + 40 ppm zinc (zn) (t2), 0.3 ppm se + 40 ppm zn + 10 ppm copper (cu) (t3), and 40 ppm zn + 10 ppm cu (t4) for 120 days, during which blood samples were collected on days 0, 40, 80, and 120. concentrations of glucose, total protein, albumin, globulin, urea, uric acid, and creatinine were similar in all the four groups. the ... | 2011 | 21947859 |
| The number of high-risk factors is related to outcome in stage II colonic cancer patients. | A subgroup of stage II colonic cancer patients are considered to be at high-risk for recurrent/metastatic disease based on 1) tumour obstruction/perforation 2) <10 lymph nodes 3) T4 lesions and 4) lymphangio-invasion. Their prognosis is regarded as comparable to stage III (T1-4N+M0) colonic cancer and it is therefore strongly advised to treat them with adjuvant chemotherapy. The purpose of this study was i) to determine the magnitude of prognostic significance of the conventional high-risk facto ... | 2011 | 21930361 |
| Competitive, non-competitive, and mixed format cleavable tag immunoassays. | Immunoassays are one of the most useful diagnostic techniques in disease assessment, drug metabolite analysis, and environmental applications due largely in part to the selectivity and sensitivity provided by antibody-antigen interactions. Here, a multiplexed immunoassay termed cleavable tag immunoassay (CTI) was performed in competitive, non-competitive, and mixed formats for the analysis of proteins and small molecule biomarkers of inflammation and tissue damage. Microchip capillary electropho ... | 2011 | 21970819 |
| Myxedema coma: a new look into an old crisis. | Myxedema crisis is a severe life threatening form of decompensated hypothyroidism which is associated with a high mortality rate. Infections and discontinuation of thyroid supplements are the major precipitating factors while hypothermia may not play a major role in tropical countries. Low intracellular T3 leads to cardiogenic shock, respiratory depression, hypothermia and coma. Patients are identified on the basis of a low index of suspicion with a careful history and examination focused on fea ... | 2011 | 21941682 |
| intensity-modulated radiotherapy combined with chemotherapy for the treatment of gastric cancer patients after standard d1/d2 surgery. | the purpose of the current study is to evaluate the efficacy and complications of concurrent chemoradiotherapy (ccrt) for the treatment of gastric cancer patients after d1/d2 surgery. | 2011 | 22105898 |
| a 5-year-old boy with atrophic autoimmune thyroiditis caused by thyroid-stimulation blocking antibodies. | a 5-year-old boy was presented for a growth disturbance, which was initially noted at 3 years of age. endocrinological testing identified severe hypothyroidism, defined by the following levels: tsh 990.5 microu/ml, f-t3 0.26 pg/ml, and f-t4 0.09 ng/dl. serum anti-thyroid peroxidase (tpo) antibodies were 158 iu/ml and serum thyroid-stimulation blocking antibodies (tsbab) levels were 82.1 iu/ml (normal range < 45.6). thyroid scintigraphy with 99mtc showed markedly decreased uptake, and magnetic re ... | 2011 | 21932608 |
| antimutator variants of dna polymerases. | evolution balances dna replication speed and accuracy to optimize replicative fitness and genetic stability. there is no selective pressure to improve dna replication fidelity beyond the background mutation rate from other sources, such as dna damage. however, dna polymerases remain amenable to amino acid substitutions that lower intrinsic error rates. here, we review these 'antimutagenic' changes in dna polymerases and discuss what they reveal about mechanisms of replication fidelity. pioneerin ... | 2011 | 21977975 |
| [sentinel lymph node biopsy as a new approach to colorectal cancer treatment]. | some concepts considering sentinel lymph node excision in colon and rectal carcinoma are presented in the paper. arguments pro and contra were exposed and interpret separately. the problem is still open. current knowledge indicates that lymphatic system in colon and rectum can be very different in many patients. there is no evidence that sentinel node biopsy in this group can be useful. in patients with advanced colorectal carcinoma (t3, t4 according to tnm classification) sentinel node biopsy c ... | 2011 | 22097185 |
| Management of the "violated neck" in the era of chemoradiation. | To determine if patients who have undergone an open neck biopsy (a "violated" neck) have improved disease control and survival with completion neck dissection. | 2011 | 21993776 |
| Evaluation of Thyroid Disorders During Head and Neck Radiotherapy by Using Functional Analysis and Ultrasonography. | PURPOSE: To evaluate thyroid function and vascular changes during radiotherapy for patients with head and neck cancer. METHODS AND MATERIALS: Fifty patients treated with primary or postoperative radiotherapy for various cancers in the head and neck region were prospectively evaluated. The serum samples (triiodothyronine [T3], thyroxine [T4], thyroid-stimulating hormone [TSH], free triiodothyronine [FT3], and free thyroxine [FT4]), the echo level of the thyroid gland, and color Doppler ultrasonog ... | 2011 | 22000746 |
| Prospective trial of chemotherapy-enhanced accelerated radiotherapy for larynx preservation in patients with intermediate-volume hypopharyngeal cancer. | BACKGROUND: Altered fractionation radiotherapy (RT) improves locoregional control in head and neck cancer without aggravation of late adverse events. To improve successful larynx-preservation rates in patients with resectable, intermediate-volume hypopharyngeal cancer, a prospective trial of chemotherapy-enhanced accelerated RT was conducted. METHODS: Patients with T2 to T4 hypopharyngeal cancer received 40 Gray (Gy)/4 weeks to the entire neck followed by boost RT administering 30 Gy/2 weeks (1. ... | 2011 | 22076936 |
| intensity-modulated radiotherapy for squamous cell carcinoma of the anal canal: efficacy of a low daily dose to clinically negative regions. | we aimed to assess outcomes of patients with anal cancer who underwent intensity-modulated radiotherapy (imrt) and received less than 1.80 gy/day. | 2011 | 21978568 |
| effects of the anti-thyroidal compound potassium-perchlorate on the thyroid system of the zebrafish. | the increasing pollution of aquatic habitats with anthropogenic compounds has led to various test strategies to detect hazardous chemicals. however, information on effects of pollutants in the thyroid system in fish, which is essential for growth, development and parts of reproduction, is still scarce. other vertebrate groups such as amphibians or mammals are well-studied; so the need for further knowledge especially in fish as a favored vertebrate model test organism is evident. modified early ... | 2011 | 22204988 |
| association of autonomously functioning thyroid nodules with hashimoto's thyroiditis: study on a large series of patients. | autonomously functioning thyroid nodules (aftns) associated with hashimoto's thyroiditis (ht) are rarely reported. this study evaluates the magnitude of such association, elaborating the clinical and biochemical characteristics of ht and aftn. | 2011 | 22068555 |
| Epidural anesthesia for repeat cesarean delivery in a parturient with Klippel-Feil syndrome. | A patient with Klippel-Feil syndrome, morbid obesity, and scoliosis required cesarean delivery. Her previous cesarean deliveries were performed under general anesthesia. She desired a regional technique. Following aspiration prophylaxis and placement of standard monitors, ultrasound was used to identify midline and L(2-3) interspace. Unintentional dural puncture occurred at 10 cm, with an inability to advance the catheter. On second attempt, an epidural catheter was placed easily. After negative ... | 2011 | 21897512 |
| Photocatalytic inactivation of bacteriophages by TiO2-coated glass plates under low-intensity, long-wavelength UV irradiation. | The International Organization for Standardization (ISO) was used to evaluate antibacterial activity by titanium dioxide (TiO(2)) photocatalysis since 2006. We evaluated photocatalytic inactivation of Qß and T4 bacteriophages induced by low-intensity, long-wavelength ultraviolet A (UVA; 0.1 mW cm(-2) and 0.001 mW cm(-2)) irradiation on a TiO(2)-coated glass plate using the ISO methodology. The results indicated that both bacteriophages were inactivated at 0.001 mW cm(-2) UVA. The intensity of UV ... | 2011 | 21931933 |
| Thyroid status two decades after salt iodisation: Country-wide data in school children from India. | Objective: Country-wide evaluation of thyroid disorders in school children following two decades of universal salt iodisation (USI) has not been carried out till date.The present study was planned with aim to assess thyroid status of school children two decades after launch of USI program. Design: Population survey Patients: We collected data from 25 schools in 19 cities across five different geographical zones of India. Those childrenwho were evaluated for anthropometry, goitre status by p ... | 2011 | 22142266 |
| suppression of ns3 and mp is important for the stable inheritance of rnai-mediated rice stripe virus (rsv) resistance obtained by targeting the fully complementary rsv-cp gene. | rice stripe virus (rsv) is a viral disease that seriously impacts rice production in east asia, most notably in korea, china, and japan. highly rsv-resistant transgenic japonica rice plants were generated using a dsrnai construct designed to silence the entire sequence region of the rsv-cp gene. transgenic rice plants were inoculated with a population of viruliferous insects, small brown planthoppers (sbph), and their resistance was evaluated using elisa and an infection rate assay. a correlatio ... | 2011 | 22134721 |
| Another 60 years in electron microscopy: development of phase-plate electron microscopy and biological applications. | It has been six decades since the concept of phase-plate electron microscopy was first reported by Boersch, but an experimental report on a phase plate with a theoretically rational performance has only recently been released by a group including the present author. Currently, many laboratories around the world are attempting to develop a wide range of phase plates to enhance the capabilities of transmission electron microscopy. They are reporting not only advantages of their own developments bu ... | 2011 | 21844600 |
| helicobacter pylori-negative gastric cancer in south korea: incidence and clinicopathologic characteristics. | it is difficult to determine the exact incidence rate of helicobacter pylori (h. pylori) infection-negative gastric cancer (hpin-gc) because h. pylori detection rates decrease with the progression of gastric atrophy and intestinal metaplasia. the aim of this study was to evaluate the incidence and clinicopathologic characteristics of hpin-gc in south korea. | 2011 | 21923684 |
| thyroid function tests during first-trimester of pregnancy: a review of literature. | this literature review was conducted to summarize the main points of maternal thyroid function tests, with particular attention in the first trimester of pregnancy which accompanied with significant biochemical and metabolic alteration. the evaluation of thyroid function of either hyperthyroidism and hypothyroidism should be assessed by determination of serum thyroid stimulating hormone (tsh), thyroxine (t4), triiodothyronine (t3), iodine and thyroid autoantibodies. glomerular filtration rate is ... | 2010 | 21848058 |
| continued reduction in the prevalence of retinopathy in adolescents with type 1 diabetes: role of insulin therapy and glycemic control. | to examine trends in microvascular complications in adolescents with type 1 diabetes between 1990 and 2009 in sydney, australia. | 2011 | 22025782 |
| Spinal Cord Intramedullary Pressure in Thoracic Kyphotic Deformity: A Cadaveric Study. | ABSTRACT: Study Design. In vitro cadaveric study of thoracic spinal cord intramedullary pressure (IMP) in kyphotic deformity.Objective. To define the relationship between thoracic spinal kyphotic deformity and spinal cord intramedullary pressure.Summary of Background Data. Previous studies of asymptomatic volunteers have revealed that there is wide variation in regional sagittal neutral upright thoracic spinal alignment with "normal" thoracic T4-T12 kyphosis ranging up to approximately +69° for ... | 2011 | 21857404 |
| [Effectiveness of neoadjuvant chemoradiotherapy of locally advanced rectal cancer in conjunction with local hyperthermia and metronidazole]. | Our study included 36 patients with hard fixed rectal tumors (T3, T4) who had received combined treatment at the Center's Clinics. On irrigoscopic evidence, lesions were more than 10 cm long. Radiotherapy was conducted thrice a week, STD of 4 Gy--TTD of 40 Gy; capecitabine, per os, 650 mg/m2 twice a day, days 1-22; oxaliplatin, 50 mg/m2, intravenously, days 3, 10 and 17; metronidazole in polymer composition, intrarectally, 10 mg/m2, twice, days 12 and 17 of radiotherapy; local hyperthermia (the ... | 2011 | 21882611 |
| gastric cancer eastern experience. | several guidelines are used for cancer therapy throughout the world. the japan gastric cancer association guideline, whereby standard surgery for t2 to t4 curable gastric cancer is defined as more than two-thirds gastrectomy with d2 dissection, are widely followed, with further data being gathered from either single institutions or nationwide registry. in the east, d2 dissection shows much better results than less extended surgery followed by adjuvant treatment. adjuvant chemotherapy without rad ... | 2012 | 22098832 |
| [genetic diversity of major capsid genes (g23) of t4-type bacteriophages in natural environments--a review]. | during the past two decades, the genetic diversities of bacterial and fungal communities and their relationship with the inhabited environments were intensively studied with the development of molecular biological techniques. however, although bacteriophages are ubiquitous and more abundant than their hosts in biosphere, their diversity is still little known. in this paper, we targeted the major capsid genes (g23) of t4-type bacteriophages and reviewed the recent progress on their genetic divers ... | 2011 | 21866696 |
| guillain-barre syndrome presenting with sensory disturbance following a herpes virus infection: a case report. | abstract: introduction: we present a case of an unusual clinical manifestation of guillain-barre syndrome following a pre-existing herpes virus infection. although there have been several reports describing the co-existence of herpes virus infection and guillain-barre syndrome, we undertook a more in-depth study of the cross-reactivity between herpes viruses and recommend a follow-up study based on serology tests. case presentation: a 39-year-old healthy caucasian man with guillain-barre syndro ... | 2011 | 22136568 |
| multifaceted suppression of aggressive behavior of thyroid carcinoma by all-trans retinoic acid induced re-differentiation. | since all-trans retinoic acid (atra) has shown promising results in differentiation therapy, the present study was designed to investigate the effects of atra on thyroid carcinoma and to evaluate the effectiveness of atra in redifferentiation induction of thyroid carcinoma. therefore, we investigated cell growth rate, morphological and nuclear: cytoplasmic ratio, adherent-dependent growth, response to chemotherapy drug following differentiation, t3 and t4 measurement, and critical genes expressi ... | 2012 | 21924320 |
| The development of articulatory awareness and the relationship between perception and production of the articulatory gesture. | To investigate the articulatory awareness of children with normal phonological development according to the variables gender, age and schooling, as well as to analyze their performances in speech perception and production tasks. | 2011 | 22012160 |
| viral elution and concentration method for detection of influenza a viruses in mud by real-time rt-pcr. | the role of environmental reservoirs in avian influenza virus (aiv) transmission has been investigated during aiv-associated outbreaks. to date, no method has been defined for detection of aiv from mud samples. a procedure using elution and polyethylene glycol (peg) concentration steps was designed to detect aiv by rt-pcr from 42g of raw mud, corresponding to 30g of the solid fraction of mud. rna was recovered with magmax ai/nd viral rna isolation kit (ambion, austin, tx). three elution buffers ... | 2012 | 22036660 |
| Tripchlorolide induces cell death in lung cancer cells by autophagy. | It has been demonstrated that triptolide inhibits the growth of several types of cancer cells in vitro and prevents tumor growth in vivo by inducing apoptosis and autophagy. Here we showed that Tripchlorolide (T4) significantly suppressed the proliferation of A549 cells in a dose- and time-dependent manner. This suppressive effect was diminished when cells were pretreated with 3-Methylamphetamine (3-MA). After the cells were treated wit ... | 2011 | 22139090 |
| Effects of thyroxine replacement on endothelial function and carotid artery intima-media thickness in female patients with mild subclinical hypothyroidism. | Previous studies have suggested an association between subclinical hypothyroidism and coronary artery disease that could be related to changes in serum lipids or endothelial dysfunction. | 2011 | 21915478 |
| [t3, t4 pathologic fracture with incompletely paralysis caused by langerhans cell histiocytosis: a case report]. | | 2011 | 22097135 |
| Hydrazide reactive peptide tags for site-specific protein labeling. | New site-specific protein labeling (SSPL) reactions for targeting-specific, short peptides could be useful for the real-time detection of proteins inside of living cells. One SSPL approach matches bioorthogonal reagents with complementary peptides. Here, hydrazide reactive peptides were selected from phage-displayed libraries using reaction-based selections. Selection conditions included washes of varying pH and treatment with NaCNBH(3) in order to specifically select reactive carbonyl-containin ... | 2011 | 21905743 |
| Is the Kidney a Major Storage Site for Thyroxine as Thyroxine Glucuronide? | Background: Previous studies have shown that thyroxine (T4) is stored as T4 glucuronide (T4G) in the kidney, and that 24 hours after administration of [(125)I]T4 to mice, 17% of the radioactivity was present in the kidneys, whereas only 4% was found in the liver. The present study was carried out to determine the relative amounts of conjugated and unconjugated T4 and 3,5,3'-triiodothyronine (T3) in the kidney and liver, and whether the conjugated hormones are extracted from tissues using our est ... | 2011 | 22175240 |
| Impact of elective neck dissection on regional recurrence and survival in cN0 staged oral maxillary squamous cell carcinoma. | To evaluate the impact of elective neck dissection (END) on regional recurrence and survival in cN0 staged patients with maxillary squamous cell carcinoma (SCC). Eighty-six patients with maxillary SCC and clinically staged N0 cervical lymph-nodes were evaluated in this single center retrospective study. Seventy-four of 86 patients were included in this analysis, of which 36 patients were treated with END, 38 without END. Following END, pathohistologically verified regional lymph-nodes in the ini ... | 2011 | 21974917 |
| effects of feeding strategies including different proportion of pasture and concentrate, on carcass and meat quality traits in uruguayan steers. | eighty four steers were randomly assigned to three pasture treatments with increasing levels of grain (t1: 0%; t2: 0.6%; t3: 1.2% of live weight) and to an ad libitum concentrate treatment, t4, to study the effects on carcass and meat quality. animals were slaughtered with 500 kg of average live weight per treatment. average daily gain increased with increasing levels of energy, determining different slaughter dates. intermediate treatments showed higher carcass weight than t1. t4 and t3 had a h ... | 2008 | 22063593 |
| the effect of heating insufflation gas on acid-base alterations and core temperature during laparoscopic major abdominal surgery. | carbon dioxide (co(2)) has different biophysical properties under different thermal conditions, which may affect its rate of absorption in the blood and the related adverse events. the present study was aimed to investigate the effects of heating of co(2) on acid-base balance using stewart's physiochemical approach, and body temperature during laparoscopy. | 2011 | 22110878 |
| Production of the stable human histamine H(1) receptor in Pichia pastoris for structural determination. | G-protein coupled receptors (GPCRs) play essential roles in regulation of many physiological processes and are one of the major targets of pharmaceutical drugs. The 3D structure can provide important information for the understanding of GPCR function and the design of new drugs. However, the success of structure determination relies largely on the production of recombinant GPCRs, because the expression levels of GPCRs are very low in native tissues except rhodopsin. All non-rhodopsin GPCRs whose ... | 2011 | 21903167 |
| nanoliter droplet array for microrna detection based on enzymatic stem-loop probes ligation and sybr green real-time pcr. | in this paper, a nanoliter droplet array based on enzymatic stem-loop probes ligation and sybr green real-time pcr for quantification of microrna was developed. by employing t4 rna ligase 2 instead of t4 dna ligase, we designed simplified stem-loop probes to perform microrna-templated dna ligation and reduced the non-specific ligation of t4 dna ligase. sybr green i dye was employed instead of taqman probes in present miniaturized real-time pcr systems. specifically, we optimized the dosage of sy ... | 2011 | 21872015 |
| blood-based biomarkers of selenium and thyroid status indicate possible adverse biological effects of mercury and polychlorinated biphenyls in southern beaufort sea polar bears. | we examined biomarkers of selenium status (whole blood se; serum se; glutathione peroxidase activity) and thyroid status (concentrations and ratios of thyroxine, t4; tri-iodothyronine, t3; albumin) in polar bears to assess variations among cohorts, and relationships to circulating concentrations of contaminants. concentrations of total mercury (hg) in whole blood were similar among cohorts (prime aged males and females, older animals, ages≥16 years, and young animals, ages 1-5 years; 48.44±35. 8 ... | 2011 | 21903210 |
| omega-3 polyunsaturated fatty acids enrichment alters performance and immune response in infectious bursal disease challenged broilers. | abstract: background: infectious bursal disease (ibd) results in economic loss due to mortality, reduction in production efficiency and increasing the usage of antibiotics. this study was carried out to investigate the modulatory roles of dietary n-3 polyunsaturated fatty acids (pufa) enrichment in immune response and performance of ibd challenged broiler chickens. methods: a total of 300 day old male broiler chicks were assigned to four dietary n-3 pufa ascending levels as the treatment group ... | 2012 | 22273277 |
| role of spinal cord in regulating mouse kidney: a virally mediated trans-synaptic tracing study. | objective: to determine the spinal innervation and neuronal connections is important for studying renal metabolic responses. materials and methods: in this study, the spinal cords of 10 adult male c57bl/6j strain mice were mapped retrograde using injections of pseudorabies virus (prv)-614. the virus, injected into the kidney, was specifically transported to the spinal cord. results: at 5 days after injection of the prv-614, prv-614-positive cells were found in the intermediolateral cell column, ... | 2012 | 22245294 |
| a population-based study of the pattern of terminal care and hospital death in patients with non-small cell lung cancer. | non-small cell lung cancer (nsclc) is a major cause of cancer-related death and utilization of health care resources worldwide. significant costs are generated in the months before death, with hospitalization being a major cost driver. moreover, hospital death causes physical and emotional distress. we analyzed factors predicting the likelihood of hospital death from nsclc. patients who died from nsclc (any stage and treatment) during the recent 5-year interval up to 31.12.2010, within a defined ... | 2012 | 22213306 |
| the role of molecular markers and tumor histological type in central lymph node metastasis of papillary thyroid carcinoma. | to look for genetic mutations that might predict central compartment lymph node metastasis (lnm) in papillary thyroid carcinoma (ptc) using strict criteria for n0 and n1 disease. | 2012 | 22249628 |
| sequence, structure, and dynamic determinants of hsp27 (hspb1) equilibrium dissociation are encoded by the n-terminal domain. | human small heat shock protein 27 (hsp27) undergoes concentration-dependent equilibrium dissociation from an ensemble of large oligomers to a dimer. this phenomenon plays a critical role in hsp27 chaperone activity in vitro enabling high affinity binding to destabilized proteins. in vivo dissociation, which is regulated by phosphorylation, controls hsp27 role in signaling pathways. in this study, we explore the sequence determinants of hsp27 dissociation and define the structural basis underlyin ... | 2012 | 22264079 |
| [diffusion-weighted mr imaging in patients with rectal cancer: our initial experience]. | pre-surgical characterization of post-neoadjuvant residual tumor response in patients with rectal cancer by means of an imaging technique could be useful in order to determine the therapeutic strategy or observation. | 2011 | 22232997 |
| serum transthyretin concentration is decreased in dogs with nonthyroidal illness. | background: hypothyroidism in dogs is often difficult to diagnose owing to nonspecific clinical signs and laboratory test results that can be mimicked by nonthyroidal illness (nti). thyroxine (t4) circulates in blood mainly bound to t4-binding globulin and, to a lesser degree, transthyretin (ttr) and albumin. the concentration of total t4 depends on the concentrations of these binding proteins. objectives: we hypothesized that dogs with nti and decreased serum total t4 concentrations would have ... | 2012 | 22250994 |
| structural mechanism of the phosphorylation-dependent dimerization of the mdc1 forkhead-associated domain. | mdc1 is a key mediator of the dna-damage response in mammals with several phosphorylation-dependent protein interaction domains. the function of its n-terminal forkhead-associated (fha) domain remains elusive. here, we show with structural, biochemical and cellular data that the fha domain mediates phosphorylation-dependent dimerization of mdc1 in response to dna damage. crystal structures of the fha domain reveal a face-to-face dimer with pseudo-dyad symmetry. we found that the fha domain recog ... | 2012 | 22234877 |
| efficacy and safety of concurrent chemoradiation with weekly cisplatin ± low-dose celecoxib in locally advanced undifferentiated nasopharyngeal carcinoma: a phase ii-iii clinical trial. | background: this is the first study that aimed to determine the efficacy and safety of concurrent chemoradiation with weekly cisplatin ± celecoxib 100 mg twice daily in locally advanced undifferentiated nasopharyngeal carcinoma. materials and methods: eligible patients had newly diagnosed locally advanced (t3-t4, and/or n2-n3, m0) undifferentiated nasopharyngeal carcinoma, no prior therapy, karnofsky performance status ≥ 70, and normal organ function. the patients were assigned to receive 7 wee ... | 2011 | 22269407 |
| topical nitrogen mustard therapy in patients with mycosis fungoides or parapsoriasis. | background topical nitrogen mustard is a chemotherapeutic agent used in treatment of mycosis fungoides (mf). objective to evaluate the response and side effects in patients with mf and parapsoriasis treated with topical nitrogen mustard. methods a retrospective study of treatment response in 116 patients diagnosed with mf and 71 patients with parapsoriasis and treated with topical nitrogen mustard from 1991 to 2009. results overall response rate and complete response (cr) rate was 91.4% and ... | 2012 | 22229501 |
| the value of diagnostic whole-body scanning and serum thyroglobulin in the presence of elevated serum thyrotropin during follow-up of anti-thyroglobulin antibody-positive patients with differentiated thyroid carcinoma who appeared to be free of disease after total thyroidectomy and radioactive iodine ablation. | background: in the presence of anti-thyroglobulin antibodies (tgab), serum thyroglobulin (tg) might be underestimated. therefore, the american thyroid association does not recommend serum tg after thyroid hormone withdrawal or recombinant human thyrotropin administration (stimulated tg) and diagnostic whole-body scanning (dxwbs) in tgab-positive patients who have serum tg values while on thyroxine (tg-on-t4) of <1 ng/ml. the objective of this study was to determine, in patients with differentiat ... | 2012 | 22224815 |
| prognostic factors for locoregional recurrences in colon cancer. | background: there is increased interest in locoregional recurrences of rectal cancer. despite comparable locoregional recurrence rates in colon cancer, only a few studies on locoregional recurrences among colon cancer patients have been published. this study was designed to identify prognostic factors for locoregional recurrences among patients with colon cancer in the netherlands. methods: the study population w ... | 2012 | 22219065 |
| reliability and validity of the multidimensional dyspnea profile (mdp). | abstract background:most measures of dyspnea assess a single aspect (intensity or distress) of the symptom. we developed the multidimensional dyspnea profile (mdp) to measure qualities and intensities of the sensory dimension and components of the affective dimension. the mdp is not indexed to a particular activity and can be applied at rest, during exertion, or clinical care. we report on the development and testing of the mdp in patients with a variety of acute and chronic cardiopulmonary cond ... | 2012 | 22267681 |
| clinical and histologic features of inverted papilloma-associated malignancy. | the objectives of the study were to analyze the clinical features of inverted papillomas (ip) associated with malignancy and to evaluate the correlation of tumor stage, survival and histolologic features. we conducted a retrospective review of 18 ip associated with malignancy patients. in addition, we compared histopathologic characteristics (tumor differentiation and malignant cell proportion) with clinical outcomes. eleven of the tumors were present on the nasal cavity and 7 on the maxillary s ... | 2012 | 22271282 |
| complete genome sequence and characterization of a broad-host range t4-like bacteriophage phias5 infecting aeromonas salmonicida subsp. salmonicida. | in this study, we report one lytic myoviridae bacteriophage (phage) infecting aeromonas salmonicida subsp. salmonicida. the phage (named as phias5) was isolated from environmental river waters in korea, and showed broad infectivity to other bacterial species in the family aeromonadaceae as well as antibiotic-resistant a. salmonicida subsp. salmonicida strains. the biological properties and complete genome of phias5 were simultaneously investigated. the complete genome of phias5 composed of linea ... | 2011 | 22226819 |
| [rocuronium vs vecuronium for neuromuscular block during transsternal thymectomy in the patient with myasthenia gravis]. | myasthenia gravis is an autoimmune disease marked by high titers of immunoglobulin g antibodies, which accelerate destruction of cholinergic receptors and interfere with neuromuscular transmission. this study aimed to determine whether neuromuscular function under a rocuronium block is different from function under a vecuronium block patients with myasthenia gravis and to describe extubation conditions in the operating room or the intensive care unit. | 2011 | 22263401 |
| wheelchair half-marathon race increases natural killer cell activity in persons with cervical spinal cord injury. | study design:non-randomized study.objective:we reported that individuals with cervical spinal cord injury (csci) showed no increase in natural killer cell activity (nkca) in response to 20-min arm exercise. it could be argued that this lack of response was owing to the short duration and intensity of the exercise.setting:the 29th oita international wheelchair marathon race.methods:the present study compared the effects of wheelchair half-marathon race on natural killer (nk) cell count, nkca and ... | 2012 | 22249325 |
| alterations in tsh and thyroid hormones following mobile phone use. | in recent years, the widespread use of mobile phones has lead to a public debate about possible detrimental effects on human health. in spite of years of research, there is still a great controversy regarding the possibility of induction of any significant physiological effects in humans by microwave radiations emitted by mobile phones. this study aims to investigate the effects of electromagnetic fields induced by the global system for mobile communications (gsm) mobile phones on the thyroid st ... | 2009 | 22216380 |
| deletion of the rnaseiii enzyme dicer in thyroid follicular cells causes hypothyroidism with signs of neoplastic alterations. | micro-rnas (mirnas) are small non-coding rnas that regulate gene expression, mainly at mrna post-transcriptional level. functional maturation of most mirnas requires processing of the primary transcript by dicer, an rnaseiii-type enzyme. to date, the importance of mirna function for normal organogenesis has been demonstrated in several mouse models of tissue-specific dicer inactivation. however, the role of mirnas in thyroid development has not yet been addressed. for the present study, we gener ... | 2012 | 22242190 |
| low concentrations of bisphenol a suppress thyroid hormone receptor transcription through a nongenomic mechanism. | bisphenol (bpa) is one of the highest-volume chemicals produced worldwide, and human exposure to bpa is thought to be ubiquitous. various rodent and in vitro studies have shown that thyroid hormone (th) function can be impaired by bpa. however, it is still unknown if low concentrations of bpa can suppress the thyroid hormone receptor (tr) transcription. the present study aims to investigate the possible suppressing effects of low concentrations of bpa on tr transcription and the involved mechani ... | 2011 | 22227104 |
| single-port laparoscopic right hemicolectomy: the first 100 resections. | : single-port laparoscopy remains a novel technique in the field of colorectal surgery. several small series have examined its safety for colon resection. | 2012 | 22228155 |
| comparisons of polybrominated diphenyl ethers levels in paired south korean cord blood, maternal blood, and breast milk samples. | polybrominated diphenyl ethers (pbdes), commonly used flame retardants, have been reported as potential endocrine disruptor and neurodevelopmental toxicants, thus giving rise to the public health concern. the goal of this study was to investigate the relationship between umbilical cord blood, maternal blood, and breast milk concentrations of pbdes in south korean. we assessed pbde levels in paired samples of umbilical cord blood, maternal blood, and breast milk. the levels of seven pbde congener ... | 2012 | 22236587 |
| a systematic review and meta-analysis of the utility of eus for preoperative staging for gastric cancer. | background: accurate preoperative staging is important in determining the appropriate treatment of gastric cancer. recently, endoscopic ultrasound (eus) has been introduced as a staging modality. however, reported test characteristics for eus in gastric cancer vary. our purpose in this study was to identify, synthesize, and evaluate findings from all articles on the performance of eus in the preoperative staging of gastric cancer. met ... | 2012 | 22237654 |
| the role of chemoradiotherapy in patients with unresectable t4 breast tumors. | purpose: unresectable t4 tumors of the breast are usually treated with systemic therapies, while the role of local therapies remains debatable. this study aims to evaluate the effectiveness of chemoradiotherapy as a part of t4 breast cancer treatment, and to assess the role of local radiotherapies in patients with unresectable t4 breast tumors. materials/methods: between february 1998 and june 2010, 39 unresectab ... | 2012 | 22274798 |
| [the expression and its potentially clinical significance of epha2 in nasopharyngeal carcinoma]. | to observe the expression of epha2, and investigate its correlation with the development, progression, invasion, metastasis, angiogenesis and prognosis in nasopharyngeal carcinoma(npc). | 2011 | 22256737 |
| the link between thyroid function and depression. | the relation between thyroid function and depression has long been recognized. patients with thyroid disorders are more prone to develop depressive symptoms and conversely depression may be accompanied by various subtle thyroid abnormalities. traditionally, the most commonly documented abnormalities are elevated t4 levels, low t3, elevated rt3, a blunted tsh response to trh, positive antithyroid antibodies, and elevated csf trh concentrations. in addition, thyroid hormone supplements appear to a ... | 2012 | 22220285 |
| differences of the lymphatic distribution and surgical outcomes between remnant gastric cancers and primary proximal gastric cancers. | background: although remnant gastric cancer (rgc) following distal gastrectomy is located in the proximal stomach, little is known about the differences of the lymphatic distribution and surgical outcomes between rgc and primary proximal gastric cancer (pgc). methods: between 1997 and 2008, 1,149 patients underwent gastrectomy for gastric cancer. of these, 33 (2.9%) rgc patients and 207 (18.5%) pgc patients were ... | 2012 | 22215245 |
| comparison of clinical outcomes for patients with large choroidal melanoma after primary treatment with enucleation or proton beam radiotherapy. | purpose: to evaluate survival and clinical outcome for patients with a large uveal melanoma treated by either enucleation or proton beam radiotherapy (pbrt). procedures: this retrospective non-randomized study evaluated 132 consecutive patients with t3 and t4 choroidal melanoma classified according to tnm stage grouping. results: cumulative all-cause mortality, melanoma-related mortality and metastasis-free survival were not statistically different between the two groups (log-rank test, p = 0.56 ... | 2012 | 22269846 |
| the determining risk factors for treatment outcomes in patients with squamous cell carcinoma of the hard palate. | background: the determining risk factors for patients with squamous cell carcinoma of the hard palate are not well verified. methods: medical records from our facility of all patients with squamous cell carcinoma of the hard palate receiving curative surgery between march 2003 and may 2009 were reviewed. results: seventy-eight patients were enrolled in ... | 2012 | 22271207 |
| effectiveness of adjuvant chemotherapy with 5-fu/leucovorin and prognosis in stage ii colon cancer. | the aims of this study were to investigate the survival results and the prognostic factors of adjuvant chemotherapy in stage ii colon cancer in the sparsity of korean data. | 2011 | 22259748 |
| endoscopic vs transfacial resection of sinonasal adenocarcinomas. | objectives. compare the survival and the complication rates of 2 comparable groups of patients who underwent either endoscopic or transfacial resection of a sinonasal adenocarcinoma.study design. historical cohort study.setting. tertiary referral center.subjects and methods. twenty-four patients with sinonasal adenocarcinomas who recently underwent an endoscopy (the endo group, 1999-2009) were compared with 24 patients who underwent a lateral rhinotomy procedure (the lr group, 1993-2007). the pr ... | 2012 | 22261496 |
| spontaneus bilateral pedicle fracture 30 years after harrington instrumentation for idiopathic scoliosis: a case report. | abstract: introduction: spontaneous fractures of the spine are a common entity. they usually occur in older people with osteoporosis. this case is presented on account of its rarity. to the best of the authors' knowledge only one case of an osteoporotic pedicle fracture after harrington instrumentation has been described before. case presentation: we report the case of a 46-year-old caucasian woman who underwent surgery due to idiopathic scoliosis with a harrington instrumentation (t4 to l3) 3 ... | 2012 | 22269652 |
| creation and validation of a ligation-independent cloning (lic) retroviral vector for stable gene transduction in mammalian cells. | abstract: background: cloning vectors capable of retroviral transduction have enabled stable gene overexpression in numerous mitotic cell lines. however, the relatively small number of feasible restriction enzyme sequences in their cloning sites can hinder successful generation of overexpression constructs if these sequences are also present in the target cdna insert. results: utilizing ligation-independent cloning (lic) technology, we have modified the highly efficient retroviral transduction ... | 2012 | 22248071 |
| a longitudinal assessment of early pubertal timing as a predictor of psychosocial changes in adolescent girls with and without spina bifida. | objective: a longitudinal comparison of adolescent girls with and without spina bifida (sb), regarding the effects of early pubertal timing on girls' depressive symptoms, mother-daughter conflict, and emotional distancing. methods: 62 mother-daughter dyads (31 with sb and 31 without) reported on psychosocial outcomes at 5 time points (ages 8/9 to 16/17 years). results: a pubertal timing × sb status interaction predicted emotional distancing (t2), conflict (t2, t5), and depressive symptoms (t4) ... | 2012 | 22271794 |
| 3,5-diiodo-l-thyronine increases resting metabolic rate and reduces body weight without undesirable side effects. | recently, it was demonstrated that 3,5-diiodo-l-thyronine (t2) stimulates the resting metabolic rate (rmr), and reduces body-weight gain of rats receiving a high-fat diet. the aim of this study is to examine the effects of chronic t2 administration on basal metabolic rate and body weight in humans. two euthyroid subjects volunteered to undergo t2 administration. body weight, body mass index, blood pressure, heart rate, electrocardiogram, thyroid and liver ultrasonography, glycemia, total cholest ... | 2011 | 22217997 |
| immune function in female b(6)c(3)f(1) mice is modulated by de-71, a commercial polybrominated diphenyl ether mixture. | polybrominated diphenyl ethers (pbdes) are an important class of flame-retardants that are environmentally persistent and bioaccumulative. toxicity of these compounds has become a concern because detectable levels of pbdes are present in humans and wildlife and they are structurally similar to polychlorinated biphenyls (pcbs). this study examined the effects of the commercial penta-bde mixture, de-71, in adult female b(6)c(3)f(1) mice on hematology, serum clinical chemistry, thyroid hormones, ti ... | 2012 | 22214215 |
| anaesthesia management for thyroidectomy in a non-euthyroid patient following cardiac failure. | a 24-year-old male thyrotoxic student of a tertiary institution had thyroidectomy in the presence of a persistently elevated thyroxine (t4) and tri-iodothyronine (t3) levels. he was initially managed for hypertension at a private hospital before he was referred to our hospital for expert management. he had symptoms of thyrotoxicosis three years before presentation at our hospital. physical examination revealed bilateral anterior neck masses and a diagnosis of toxic goitre was made. the serum t3 ... | 2011 | 22248956 |
| tsh neurosecretory dysfunction (tsh-nd) in down syndrome (ds): low risk of progression to hashimoto's thyroiditis. | patients with down syndrome (ds) often have elevated tsh (hypothalamic origin), which is called tsh neurosecretory dysfunction (tsh-nd). in these cases, there is slight elevation in tsh (5-15 µui/ml), with normal free t4 and negative thyroid antibodies (ab). | 2011 | 22218446 |
| [myoepithelial carcinoma of salivary glands: a clinical analysis of 13 cases]. | this study retrospectively analyzed the clinical data of 13 patients with myoepithelial carcinoma of salivary glands for improving the accuracy of diagnosis and treatment outcome. | 2011 | 22241311 |