| crystal structure of the bacteriophage t4 late-transcription coactivator gp33 with the β-subunit flap domain of escherichia coli rna polymerase. | activated transcription of the bacteriophage t4 late genes, which is coupled to concurrent dna replication, is accomplished by an initiation complex containing the host rna polymerase associated with two phage-encoded proteins, gp55 (the basal promoter specificity factor) and gp33 (the coactivator), as well as the dna-mounted sliding-clamp processivity factor of the phage t4 replisome (gp45, the activator). we have determined the 3.0 å-resolution x-ray crystal structure of gp33 complexed with it ... | 2011 | 22135460 |
| Multivisceral and standard resections in colorectal cancer. | The current study was designed to identify prognostic factors for long-term survival in patients with advanced colorectal cancer in a consecutive cohort. | 2012 | 21968828 |
| [Clinical analysis of 42 cases with adenoid cystic carcinoma of the nasal cavity]. | To study the clinical characters, treatment, outcome and the factors affecting long-term treatment results of adenoid cystic carcinoma (ACC) of the nasal cavity. | 2011 | 21950002 |
| Effects of a monophasic combined oral contraceptive containing nomegestrol acetate and 17ß-oestradiol in comparison to one containing levonorgestrel and ethinylestradiol on markers of endocrine function. | To compare the effects of two monophasic combined oral contraceptives, containing either nomegestrol acetate/17ß-oestradiol (NOMAC/E2) or levonorgestrel/ ethinylestradiol (LNG/EE) on endocrine function, androgens, and sex hormone-binding globulin (SHBG). | 2011 | 21942708 |
| characterization of a vii-like phage specific to escherichia coli o157:h7. | phage vb_ecom_cba120 (cba120), isolated against escherichia coli o157:h7 from a cattle feedlot, is morphologically very similar to the classic phage vii of salmonella enterica serovar typhi. until recently, little was known genetically or physiologically about the vii-like phages, and none targeting e. coli have been described in the literature. the genome of cba120 has been fully sequenced and is highly similar to those of both vii and the shigella phage ag3. the core set of structural and repl ... | 2011 | 21899740 |
| variations in vertebral body dimensions in women measured by 3d-xa: a longitudinal in vivo study. | bone size and shape play an important role in bone strength, as shown by biomechanical testing and clinical studies. vertebral body dimensions determine vertebral body strength even after adjustment for bone mineral density. we have recently proposed an in vivo method for 3d reconstruction of vertebral bodies using the whole spine imaging on a standard dxa device (3d-xa). the aim of our study was to measure in vivo vertebral body dimension changes by 3d-xa in women over a 6year period. a total o ... | 2011 | 22207276 |
| treatment outcomes and prognostic features in adenoid cystic carcinoma originated from the head and neck. | surgery is the main treatment modality for adenoid cystic carcinoma (acc) originated from the head and neck. however, the extensive local infiltrative and perineural spread related to this malignancy often cause difficulty to achieve high tumor control. the aim of this study is to evaluate the efficacy of postoperative radiotherapy (rt) in acc, and to identify prognostic variables associated with treatment outcomes. a retrospective review of 101 patients diagnosed with acc in the head and neck r ... | 2011 | 22209446 |
| redox status and pro-survival/pro-apoptotic protein expression in the early cardiac hypertrophy induced by experimental hyperthyroidism. | this study was conducted to analyse the redox status and redox-sensitive proteins that may contribute to a non-genomic mechanism of cardiac hypertrophy induction by hyperthyroidism. wistar rats, treated with l-thyroxine (t4) during 2 weeks (12 mg·l(-1) in drinking water), presented cardiac hypertrophy (68% higher than control), without signals of liver or lung congestion. myocardial reduction of the reduced glutathione: oxidized glutathione (gssg) ratio (45%) (redox status) and elevation in hydr ... | 2011 | 21989893 |
| [Preoperative staging MRI for rectal cancer and pathologic correlation]. | Our aim is to asses the accuracy of MRI for preoperative rectal cancer staging and to establish a histopathologic correlation. | 2011 | 21904400 |
| four-week neoadjuvant intensity-modulated radiation therapy with concurrent capecitabine and oxaliplatin in locally advanced rectal cancer patients: a validation phase ii trial. | purpose: to validate tolerance and pathological complete response rate (pcr) of a 4-week preoperative course of intensity-modulated radiation therapy (imrt) with concurrent capecitabine and oxaliplatin (capox) in patients with locally advanced rectal cancer. methods and materials: patients with t3 to t4 and/or n+ rectal cancer received preoperative imrt (47.5 gy in 19 fractions) with concurrent capecitabine (825 mg/m(2) b.i.d., monday to friday) and oxaliplatin (60 mg/m(2) on days 1, 8, and 15). ... | 2011 | 22079731 |
| thyrotoxic hypokalaemic periodic paralysis in a man from nepal. | a case is presented of a rare complication of hyperthyroidism, known as thyrotoxic hypokalaemic periodic paralysis, in a man from nepal. a 26-year-old nepalese man, with known hypokalaemia, was referred to the clinical laboratory services for electrolyte analysis. results showed na(+) 120 mmol/l and k(+) 2.8 mmol/l, and he was prescribed potassium chloride. in fact, he had previously been receiving potassium supplementation periodically and his history revealed that he had experienced the same t ... | 2009 | 21894247 |
| primary radiotherapy with or without chemotherapy in non-metastatic esophageal squamous cell carcinoma: a retrospective study. | the purpose of this study was to report the outcome of radio(chemo)therapy in the curative management of esophageal squamous cell carcinoma (escc). we retrospectively analyzed 163 patients with t1-t4, n0-1, m0 escc who were treated between january 1988 and december 2006 at the technische universität münchen. one hundred sixty patients were inoperable due to a poor performance status, comorbidities or locally advanced unresectable disease. external beam radiation therapy (ebrt) was performed with ... | 2011 | 21899651 |
| Parental Transfer of Polybrominated Diphenyl Ethers (PBDEs) and Thyroid Endocrine Disruption in Zebrafish. | Polybrominated diphenyl ethers (PBDEs) have the potential to disrupt the thyroid endocrine system. The objective of the present study was to characterize the disrupting effects of long-term exposure on the thyroid endocrine system in adult fish and their progeny following parental exposure to PBDEs. Zebrafish (Danio rerio) embryos were exposed to environmentally relevant concentrations (1, 3, and 10 µg/L) of the PBDE mixture DE-71 for 5 months until sexual maturation. In the F0 generation, expos ... | 2011 | 22039834 |
| Why can insulin resistance be a natural consequence of thyroid dysfunction? | Evidence for a relationship between T4 and T3 and glucose metabolism appeared over 100 years ago when the influence of thyroid hormone excess in the deterioration of glucose metabolism was first noticed. Since then, it has been known that hyperthyroidism is associated with insulin resistance. More recently, hypothyroidism has also been linked to decreased insulin sensitivity. The explanation to this apparent paradox may lie in the differential effects of thyroid hormones at the liver and periphe ... | 2011 | 21941681 |
| Functional and sensitive outcomes after tongue reconstruction: About a series of 30 patients. | Few studies reported both functional and sensitive long-term evaluations after tongue reconstruction. The aim of this study was to assess functional outcomes and sensitive recovery after tongue reconstruction with fasciocutaneous free flap (FCFF) or musculocutaneous pedicled flap (MCPF) without nerve anastomosis. We enrolled 30 patients having no recurrence from a consecutive series of 79 tongue reconstructions as part of a cancer treatment. All patients were submitted to functional and sensitiv ... | 2011 | 22137578 |
| The strengths and limitations of routine staging before treatment with abdominal CT in colorectal cancer. | ABSTRACT: | 2011 | 21982508 |
| Transient congenital hypothyroidism. | Transient thyroid function abnormalities in the new born which revert back to normal after varying periods of time are mostly identified in the neonatal screening tests for thyroid and are becoming more common because of the survival of many more premature infants. It can be due to factors primarily affecting the thyroid-like iodine deficiency or excess, maternal thyroid-stimulating hormone receptor (TSHR) antibodies, maternal use of antithyroid drugs, DUOX 2 (dual oxidase 2) mutations, and prem ... | 2011 | 21966647 |
| overt and subclinical hypothyroidism: who to treat and how. | hypothyroidism denotes deficient production of thyroid hormone by the thyroid gland and can be primary (abnormality in thyroid gland itself) or secondary/central (as a result of hypothalamic or pituitary disease). the term 'subclinical hypothyroidism' is used to define that grade of primary hypothyroidism in which there is an elevated thyroid-stimulating hormone (tsh) concentration in the presence of normal serum free thyroxine (t4) and triiodothyronine (t3) concentrations. subclinical hypothyro ... | 2012 | 22191793 |
| decreased cognitive functioning in patients with advanced oral squamous cell carcinoma. | cognitive impairment causes a delay in diagnosis and treatment of the various cancer entities, resulting in reduced surgical outcomes and patient survival. however, no investigations have been carried out as to whether an association exists between cognitive functioning and tumour size in patients with oral squamous cell carcinoma (oscc). in this study, 46 patients with oscc were evaluated by using a screening test for dementia, consisting of a combination of the mini-mental state examination an ... | 2011 | 21903447 |
| maternal thyroid function during the second half of pregnancy and child neurodevelopment at 6, 12, 24, and 60 months of age. | although evidence suggests that maternal hypothyroidism and mild hypothyroxinemia during the first half of pregnancy alters fetal neurodevelopment among euthyroid offspring, little data are available from later in gestation. in this study, we measured free t4 using direct equilibrium dialysis, as well as total t4 and tsh in 287 pregnant women at 27 weeks' gestation. we also assessed cognition, memory, language, motor functioning, and behavior in their children at 6, 12, 24, and 60 months of age. ... | 2011 | 22132346 |
| structure and dynamics of a conformationally constrained nitroxide side chain and applications in epr spectroscopy. | a disulfide-linked nitroxide side chain (r1) is the most widely used spin label for determining protein topology, mapping structural changes, and characterizing nanosecond backbone motions by site-directed spin labeling. although the internal motion of r1 and the number of preferred rotamers are limited, translating interspin distance measurements and spatial orientation information into structural constraints is challenging. here, we introduce a highly constrained nitroxide side chain designate ... | 2011 | 21911399 |
| prediction of enzyme mutant activity using computational mutagenesis and incremental transduction. | wet laboratory mutagenesis to determine enzyme activity changes is expensive and time consuming. this paper expands on standard one-shot learning by proposing an incremental transductive method (t2brf) for the prediction of enzyme mutant activity during mutagenesis using delaunay tessellation and 4-body statistical potentials for representation. incremental learning is in tune with both escience and actual experimentation, as it accounts for cumulative annotation effects of enzyme mutant activit ... | 2011 | 22007208 |
| 55.1, a gene of unknown function of phage T4, impacts on Escherichia coli folate metabolism and blocks DNA repair by the NER. | Phage T4, the archetype of lytic bacterial viruses, needs only 62 genes to propagate under standard laboratory conditions. Interestingly, the T4 genome contains more than 100 putative genes of unknown function, with few detectable homologues in cellular genomes. To characterize this uncharted territory of genetic information, we have identified several T4 genes that prevent bacterial growth when expressed from plasmids under inducible conditions. Here, we report on the various phenotypes and mol ... | 2011 | 22029793 |
| structural conservation of the myoviridae phage tail sheath protein fold. | bacteriophage phikz is a giant phage that infects pseudomonas aeruginosa, a human pathogen. the phikz virion consists of a 1450 å diameter icosahedral head and a 2000 å-long contractile tail. the structure of the whole virus was previously reported, showing that its tail organization in the extended state is similar to the well-studied myovirus bacteriophage t4 tail. the crystal structure of a tail sheath protein fragment of phikz was determined to 2.4 å resolution. furthermore, crystal structur ... | 2011 | 22153511 |
| Caveolin-1 as a potential high-risk prostate cancer biomarker. | Current diagnostic techniques of prostate cancer cannot efficiently distinguish the latent and low-risk forms from the high-risk significant forms of prostate cancer. Caveolin-1 (Cav-1), except other functions, plays an important role in cell transformation and the process of tumorigenesis. Furthermore, Cav-1 is involved in metastatic processes. It has also been shown that Cav-1 expression is induced under stress conditions, such as oxi ... | 2011 | 22159333 |
| the biomechanics of the pediatric and adult human thoracic spine. | a growing body of literature points out the relevance of the thoracic spine dynamics in understanding the thorax-restraint interaction as well as in determining the kinematics of the head and cervical spine. this study characterizes the dynamic response in bending of eight human spinal specimens (4 pediatric: ages 7 and 15 years, 4 adult: ages 48 and 52 years) from two sections along the thoracic spine (t2-t4 and t7-t9). each specimen consisted of three vertebral bodies connected by the correspo ... | 2011 | 22105396 |
| UV-induced DNA damage and DNA repair in ribosomal genes chromatin. | Cyclobutane pyrimidine dimers (CPDs) and (6,4) pyrimidine-pyrimidone dimers are the major DNA lesions (or photoproducts) induced by ultraviolet light and are removed by the nucleotide excision repair (NER) pathway. If not repaired, DNA damage can lead to genome instability. The genome is organized into nuclear domains with distinct functions and chromatin structures. Although studies on NER in all chromosomal contexts are important to understand the mechanisms of genome maintenance, we focused o ... | 2012 | 22113285 |
| (32)P-postlabelling for the Sensitive Detection of DNA Adducts. | 32P-postlabelling is a technique originally described by Kurt Randerath and colleagues for the sensitive detection of damage produced in DNA by reactive chemicals or genotoxins. The procedure essentially entails the enzymatic digestion of DNA to nucleoside 3'-monophosphates which are then radioactively labelled using T4 polynucleotide kinase and [?(32)P]-adenosine triphosphate. Adducted nucleoside-3'-5'-bisphosphates are then separated from their normal counterparts by thin layer chromatography. ... | 2012 | 22147574 |
| how a dna polymerase clamp loader opens a sliding clamp. | processive chromosomal replication relies on sliding dna clamps, which are loaded onto dna by pentameric clamp loader complexes belonging to the aaa+ family of adenosine triphosphatases (atpases). we present structures for the atp-bound state of the clamp loader complex from bacteriophage t4, bound to an open clamp and primer-template dna. the clamp loader traps a spiral conformation of the open clamp so that both the loader and the clamp match the helical symmetry of dna. one structure reveals ... | 2011 | 22194570 |
| Investigation of thyroid dysfunction in general practice is more likely in patients with high psychological morbidity. | BACKGROUND: Mild or subclinical hypothyroidism [raised thyroid-stimulating hormone (TSH) but normal free thyroxine (T4)] affects 5-10% of adults. Symptoms are non-specific and TSH levels are needed for diagnosis. OBJECTIVES: We explore the relationship between thyroid function and psychological distress and investigate the usefulness of an expert-designed Thyroid Symptom Questionnaire (TSQ) in identifying hypothyroidism. METHODS: DEPTH (DEPression and THyroid) is a cross-sectional study of 325 p ... | 2011 | 21890841 |
| [Administration of sugammadex to a patient with myasthenia gravis with fade of the train-of-four ratio]. | A 50-year-old man (weight 87 kg, height 171 cm) with myasthenia gravis (MG) was scheduled for extended thymectomy under general anesthesia. His preanesthetic train-of-four ratio (T4/T1) was 59%. The first twitch of the train-of-four (T1) was 130% after calibration. We administered rocuronium 10 mg (0.11 mg x kg(-1)) for tracheal intubation. Maximal suppression was achieved in 50 seconds. During the operation, we did continuous infusion of rocuronium to maintain T1 at 10%. We discontinued rocuron ... | 2011 | 21950042 |
| sephardic signature in haplogroup t mitochondrial dna. | a rare combination of mutations within mitochondrial dna subhaplogroup t2e is identified as affiliated with sephardic jews, a group that has received relatively little attention. four investigations were pursued: search of the motif in 250 000 control region records across 8 databases, comparison of frequencies of t subhaplogroups (t1, t2b, t2c, t2e, t4, t(*)) across 11 diverse populations, creation of a phylogenic median-joining network from public t2e control region entries, and analysis of on ... | 2011 | 22108605 |
| Value of Repeat Stimulated Thyroglobulin Testing in Patients with Differentiated Thyroid Carcinoma Considered to Be Free of Disease in the First Year After Ablation. | Background: In patients with differentiated thyroid carcinoma considered to be free of the disease after initial therapy, the appropriate timing or necessity of subsequent stimulated thyroglobulin (Tg) testing is uncertain. The objective of this study was to determine the value of a repeat stimulated Tg in patients considered to be free of disease 6-12 months after thyroid ablation, and also who continued to have serum Tg <1?ng/mL while on thyrotropin suppressive doses of thyroxine (T4) (Tg/T4), ... | 2011 | 22175271 |
| Kinematic analysis of kicking in young top-class soccer players. | The aim of this study was to describe the kinematic pattern of the kicking movement of young top-class soccer players focusing in examining the linear joint markers velocity of the leg kick and the segments angular position. | 2011 | 21904274 |
| Reproductive biomarkers to identify endocrine disruption in Clarias gariepinus exposed to 4-nonylphenol. | The present study investigated the hormones concentrations and gonads alterations of Clarias gariepinus caused by sublethel concentrations of 4-nonylphenol (0, 0.05, 0.08 and 0.1mg/l). The changes in the activities of the hormones after exposure to these sublethel doses of 4-nonylpenol referred to endocrine disruption in Clarias gariepinus in association with histopathological changes in reproductive tissues. The levels of thyroid stimulating hormone (TSH), triiodothyronine (T3), total thyroxine ... | 2011 | 22177982 |
| The miR-143/-145 cluster regulates plasminogen activator inhibitor-1 in bladder cancer. | Background:Upregulation of the proto-oncogene plasminogen activator inhibitor-1 (PAI-1) is a common hallmark of various solid tumours, but the mechanisms controlling its expression are not fully understood.Methods:We investigate microRNAs (miRNAs) regulating PAI-1 in a panel of normal bladder urothelial biopsies, superficial Ta bladder tumours and invasive T1-T4 tumours using expression microarrays and qRT-PCR. The prognostic implications of PAI-1 deregulation are established by tissue microarra ... | 2011 | 22108519 |
| Initial PET/CT staging for choroidal melanoma: AJCC correlation and second nonocular primaries in 333 patients. | Purpose. To report on whole body positron emission tomography/computed tomography (PET/CT) screening for metastasis at diagnosis of primary uveal melanoma. Methods. Since August 2003, 333 consecutive patients were diagnosed with uveal melanoma and underwent whole body screening for metastatic disease with PET/CT along with liver function tests and physical examination. Abnormal findings prompted further biopsies, blood tests, imaging, or clinical evaluations for confirmation. The presence of met ... | 2011 | 21959680 |
| the presence of facial nerve weakness on diagnosis of a parotid gland malignant process. | the objectives of this article are to assess the frequency and significance of facial paralysis and undiagnosed nerve infiltration in patients with parotid malignancies. 103 patients with parotid gland malignancies were treated in a single institution, the tertiary center for ent at the university department in poznan between 1996 and 2006. facial palsy at the initial presentation was found in 32 patients. the stage of the primary tumor in the examined group of 103 patients is as follows: 20-t1, ... | 2011 | 22179671 |
| Prognostic significance of cyclooxygenase-2, epidermal growth factor receptor 1, and microvascular density in gastric cancer. | Gastric cancer remains a significant global health burden with poor treatment outcome. New treatment modalities that target inflammation, proliferation, and angiogenesis have been used in various cancers, including gastric cancer. We sought to study the pattern of expression of two important proteins, cyclooxygenase-2 and epidermal growth factor receptor, and their association with microvascular density, clinicopathological features, and survival in Arab Omani patients with gastric cancer. Forma ... | 2011 | 22048943 |
| whole-pelvis or bladder-only chemoradiation for lymph node-negative invasive bladder cancer: single-institution experience. | purpose: whole-pelvis (wp) concurrent chemoradiation (ccrt) is the standard bladder preserving option for patients with invasive bladder cancer. the standard practice is to treat elective pelvic lymph nodes, so our aim was to evaluate whether bladder-only (bo) ccrt leads to results similar to those obtained by standard wp-ccrt. methods and materials: patient eligibility included histopathologically proven muscle-invasive bladder cancer, lymph nodes negative (t2-t4, n-) by radiology, and maximal ... | 2011 | 21945107 |
| enantioselective cleavage of supercoiled plasmid dna catalyzed by chiral macrocyclic lanthanide(iii) complexes. | the enantiomers of the sm (iii), eu (iii) and yb (iii) complexes [lnl(no(3))(2)](no(3)) of a chiral hexaazamacrocycle were tested as catalysts for the hydrolytic cleavage of supercoiled plasmid dna. the catalytic activity was remarkably enantioselective; while the [lnl(ssss)(no(3))(2)](no(3)) enantiomers promoted the cleavage of plasmid pbr322 from the supercoiled form (sc) to the nicked form (nc), the [lnl(rrrr)(no(3))(2)](no(3)) enantiomers were inactive. kinetics of plasmid dna hydrolysis was ... | 2011 | 22169034 |
| A new strategy for the synthesis of bisaminoacylated tRNAs. | Tandemly activated tRNAs participate effectively in protein synthesis and exhibit superior chemical and biochemical stability compared to the more commonly used singly aminoacylated tRNAs. While several bisaminoacylated tRNAs have been prepared via the T4 RNA ligase-mediated condensation of bisaminoacylated pdCpAs and abbreviated tRNA transcripts (tRNA-C(OH)), the bisaminoacylated pdCpAs are difficult to prepare when using bulky amino acids. Described herein is a new strategy for preparing bisam ... | 2011 | 21861452 |
| tertiary hypothyroidism in a dog. | : a nine-year-old male entire labrador was diagnosed with pituitary dependent hyperadrenocorticism. following seven months of successful mitotane therapy, the dog presented with marked weight gain, seborrhoea and alopecia. routine clinicopathological analyses revealed marked hypercholesterolaemia. serum total and free thyroxine (t4) concentrations were below their respective reference ranges. serum thyroid stimulating hormone (ctsh) concentration was within reference range. tsh and thyrotropin r ... | 2007 | 21851691 |
| Expression of programmed cell death protein 4 (PDCD4) and miR-21 in urothelial carcinoma. | BACKGROUND: We investigated the role of the programmed cell death 4 (PDCD4) tumor suppressor gene in specimens of transitional cell carcinoma and of healthy individuals. METHODS: PDCD4 immunohistochemical expression was investigated in 294 cases in histologically proven transitional cell carcinoma in different tumorous stages (28 controls, 122 non-muscle invasive urothelial carcinoma, stages Tis-T1, 119 invasive transitional cell carcinoma stages T2-T4 and 25 metastases). MiR-21 expression, an i ... | 2011 | 22133680 |
| aluminium effects on thyroid gland function: iodide uptake, hormone biosynthesis and secretion. | the effects of aluminium (al) on thyroid function were evaluated in adult wistar rats intraperitoneally (i.p) injected with 7 mg al (as lactate)/kg body weight (b.w) per day during a six week period. the time-course kinetics of na(125)i (3 μci per 100 g b.w, i.p) was analysed by measuring gamma-radioactivity of thyroid, serum, serum protein precipitate and bile, at times ranging from 2 to 96 h post-dosing. in al-treated group the (125)i(-) thyroid uptake at 24 h (15,840 ± 570 vs. 18,030 ± 630 dp ... | 2011 | 22099156 |
| neuropsychological function in patients who have had epilepsy surgery: a long-term follow-up. | we examined the relationship between seizure outcomes and long-term changes in memory and intellectual function in 70 patients who had undergone temporal lobe resection for medically intractable epilepsy. patients were assessed on four occasions: preoperatively (t1), 3months postoperatively (t2), 1year postoperatively (t3), and more than 5years postoperatively (t4). the majority of patients had stable memory function across the assessments. however, many were functioning below the 15th percentil ... | 2011 | 22100066 |
| [Resistant ovary syndrome. Case report]. | Patients with primary amenorrhea, sexual infantilism and elevated pituitary gonadotropins are frequently diagnosed with hypogonadism hypergonadotropic and suspected ovarian failure, secondary to a chromosomal abnormality, intrinsic ovarian failure or altered receptors for gonadotropins, mainly FSH (ovarian resistance). We report the case of a 16-year-old, admitted to the endocrinology clinic for primary amenorrhea and lack of development of secondary sexual characteristics. A complete physical e ... | 2011 | 21966839 |
| labelled antibody-based one-step time-resolved fluoroimmunoassay for measurement of free thyroxine in serum. | valid assays measuring free thyroxine (ft4) must perform without bias despite large variations in the concentrations and affinities of serum thyroxine-binding proteins in the population. we developed a new, rapid one-step labelled-antibody time-resolved fluoroimmunoassay (trfia) for ft4. | 2011 | 21885471 |
| presence of free cancer cells in the peritoneal cavity of patients who underwent curative gastrectomy with lymph node dissection. | background/aims: the aim of this study was to determine the ratio of patients with positive peritoneal cytology who underwent radical gastrectomy for gastric cancer, to evaluate the factors effecting risk of positive cytology and to analyze the effects cytology findings on survival. methodology: peritoneal lavage samples were obtained from 255 patients who underwent radical gastrectomy with d2 (184 patients) or d3 (71 patients) lymph node dissection between january 2000 and december 2007. result ... | 2011 | 22155861 |
| comparison of treatment results between surgery alone, preoperative short-course radiotherapy, or long-course concurrent chemoradiotherapy in locally advanced rectal cancer. | background: the aim of this study is to compare the results between surgery alone, preoperative radiotherapy (rt), or preoperative concurrent chemoradiotherapy (ccrt) followed by surgery in the treatment of locally advanced rectal cancer in asian patients. methods: this study included 151 consecutive patients with clinical t3, t4 or node-positive rectal cancer from jan. 2005 to dec. 2007. eighty-six patients underwent total mesorectal excision (tme) alone, 28 patients received preoperative rt (2 ... | 2011 | 21938495 |
| [influence of acupuncture of zusanli (st 36) on connectivity of brain functional network in healthy subjects]. | to observe the effect of acupuncture of zusanli (st 36) on electroencephalogram (eeg) so as to probe into its law in regulating the interconnectivity of brain functional network. | 2011 | 21942182 |
| towards a structural comprehension of bacterial type vi secretion systems: characterization of the tssj-tssm complex of an escherichia coli pathovar. | type vi secretion systems (t6ss) are trans-envelope machines dedicated to the secretion of virulence factors into eukaryotic or prokaryotic cells, therefore required for pathogenesis and/or for competition towards neighboring bacteria. the t6ss apparatus resembles the injection device of bacteriophage t4, and is anchored to the cell envelope through a membrane complex. this membrane complex is composed of the tssl, tssm and tagl inner membrane anchored proteins and of the tssj outer membrane lip ... | 2011 | 22102820 |
| phase ii trial of preoperative paclitaxel, gemcitabine, and trastuzumab combination therapy in her2 positive stage ii/iii breast cancer: the korean cancer study group br 07-01. | an addition of trastuzumab preoperatively to chemotherapy for human epidermal growth factor receptor 2 (her2) positive breast cancer improved relapse-free survival (rfs). this study was designed to evaluate the efficacy and safety of preoperative paclitaxel, gemcitabine, and trastuzumab (pgh) combination for her2-positive breast caner. pathologically, proven node positive stage ii/iii breast cancer patients with adequate organ function and no history of anti-cancer therapy were eligible. patient ... | 2011 | 22094934 |
| prognostic value of prevertebral space involvement in nasopharyngeal carcinoma based on intensity-modulated radiotherapy. | purpose: to investigate the prognostic significance of prevertebral space involvement (psi) in patients with nasopharyngeal carcinoma (npc) treated with intensity-modulated radiotherapy (imrt). methods and materials: a retrospective review of data from 506 biopsy-proven, nonmetastatic npcs was performed. patients underwent magnetic resonance imaging examinations and received imrt as their primary treatment. results: in this series, 161 npc patients (31.8%) had psi. parapharyngeal space (p < 0.00 ... | 2011 | 21864993 |
| laminectomy, durotomy, and piotomy effects on spinal cord intramedullary pressure in severe cervical and thoracic kyphotic deformity: a cadaveric study. | object previous studies have shown that cervical and thoracic kyphotic deformity increases spinal cord intramedullary pressure (imp). using a cadaveric model, the authors investigated whether posterior decompression can adequately decrease elevated imp in severe cervical and thoracic kyphotic deformities. methods using an established cadaveric model, a kyphotic deformity was created in 16 fresh human cadavers (8 cervical and 8 thoracic). a single-level rostral laminotomy and durotomy we ... | 2011 | 22077470 |
| The Evolution of Thyroid Function with Puberty. | Objective: This study was planned to describe thyroid functional status in different stages of puberty. Study design: We collected data from 5 schools across different geographical zones of Delhi. All children who consented were evaluated for anthropometry, pubertal stage, goitre status, serum free T3 (FT3), free T4 (FT4), TSH, anti-TPO (thyroid peroxidase) antibodies and thyroid ultrasound. From this sample, a disease- and risk-free or "reference population" was obtained by excluding those wi ... | 2011 | 22171622 |
| structure and function of the small terminase component of the dna packaging machine in t4-like bacteriophages. | tailed dna bacteriophages assemble empty procapsids that are subsequently filled with the viral genome by means of a dna packaging machine situated at a special fivefold vertex. the packaging machine consists of a "small terminase" and a "large terminase" component. one of the functions of the small terminase is to initiate packaging of the viral genome, whereas the large terminase is responsible for the atp-powered translocation of dna. the small terminase subunit has three domains, an n-termin ... | 2011 | 22207623 |
| an exploratory study of the influence of clinico-demographic variables on swallowing and swallowing-related quality of life in a cohort of oral and oropharyngeal cancer patients treated with primary surgery. | there are insufficient data on swallowing and the consequences of its dysfunction in patients with cancers of the oral cavity (oc) and oropharynx (op) that are treated with primary surgery. the study attempts to explore the effect of important clinico-demographic variables on post-treatment swallowing and related quality of life (qol) in post-surgical oc and op cancer patients. sixty-two consecutive oc and op cancer patients completed the md anderson dysphagia inventory (mdadi) questionnaire. me ... | 2011 | 21909656 |
| comparative study of perdialytic volemia variability in chronic dialysis patients between acetate- free biofiltration and bicarbonate hemodialysis. | we have developed since 1994 a new hemodialysis (hd) technique called acetate biofiltration 84% (afb 84%) that is characterized by the absence of acetate in the dialysate and the complete correction of buffer balance by post- dilutional infusion of bicarbonate- based replacement solution. our study aimed to compare the variability of perdialytic volemia [net ultrafiltration (uf) rate, total uf, δweight (t4- t0)] during afb 84% and bicarbonate dialysis (bd) for stable chronic hemodynamic patients ... | 2011 | 21912029 |
| a missed injury leading to delayed diagnosis and postoperative infection of an unstable thoracic spine fracture - case report of a potentially preventable complication. | abstract: | 2011 | 21999783 |
| number of lymph nodes retrieved is an important determinant of survival of patients with stage ii and stage iii colorectal cancer. | the number of lymph nodes retrieved is recognized to be a prognostic factor of stage ii colorectal cancer. however, the prognostic significance of the number of lymph nodes retrieved in stage iii colorectal cancer remains controversial. | 2012 | 22102737 |
| site-specific isotope labeling of long rna for structural and mechanistic studies. | a site-specific isotope labeling technique of long rna molecules was established. this technique is comprised of two simple enzymatic reactions, namely a guanosine transfer reaction of group i self-splicing introns and a ligation with t4 dna ligase. the trans-acting group i self-splicing intron with its external cofactor, 'isotopically labeled guanosine 5'-monophosphate' (5'-gmp), steadily gave a 5'-residue-labeled rna fragment. this key reaction, in combination with a ligation of 5'-remainder n ... | 2012 | 22080547 |
| a fate model of pathogenic viruses in a composting toilet based on coliphage inactivation. | a composting toilet using sawdust as a matrix has the potential to trap pathogens that might occasionally be contained in human feces. therefore, care should be taken when handling the sawdust. it should also be noted that pathogenic viruses tend to have stronger tolerance than pathogenic bacteria. the fates of several species of coliphages, t4, lambda, qbeta and ms2, in sawdust were investigated as a viral model. the fates of coliphages were significantly different among them, and they changed ... | 2011 | 22125914 |
| Effect of ELTGOL on Mucus Clearance in Stable Patients With Chronic Bronchitis. | BACKGROUND: Slow expiration with glottis opened in lateral posture (ELTGOL) has been used in clinical practice to improve mucus clearance from peripheral airways. The purpose of this crossover study was to evaluate the effect of ELTGOL on mucus clearance of right and left lungs, especially of peripheral lung areas, in stable patients with chronic bronchitis. METHODS: Twelve 45 to 75 year-old patients (10 of whom had mild to moderate Chronic Obstructive Pulmonary Disease (COPD) according to GOLD) ... | 2011 | 22005107 |
| A meta-analysis of D1 versus D2 lymph node dissection. | BACKGROUND: Surgery is the only curative treatment for patients with gastric cancer. However, the extent of lymph node dissection is still debated. Therefore, with the publication of newer trial results, we conducted an updated meta-analysis of D1 versus D2 randomized controlled trials comparing outcomes. METHODS: Systematic searches were conducted using Medline, Embase, and the Cochrane Central Register of Contr ... | 2011 | 22138927 |
| Stage IV Colorectal Cancers: An Analysis of Factors Predicting Outcome and Survival in 728 cases. | INTRODUCTION: Stage IV colorectal cancer (CRC) is a heterogeneous disease with many treatment options. The optimum management algorithm is yet to be established. The aim of this study was to evaluate the prognostic factors of survival and to determine the operative benefit of resection of the primary tumour followed by chemotherapy. METHODS: Seven hundred twenty-eight consecutive patients who presented with stage ... | 2011 | 22009464 |
| completely laparoscopic versus open gastrectomy for early and advanced gastric cancer: a matched cohort study. | introduction: the application of laparoscopic gastric surgery has rapidly increased for the treatment of early gastric cancer. however, laparoscopic gastrectomy for advanced tumor remains controversial, particularly in terms of oncologic outcomes. this study was designed to compare 3-year survival of laparoscopic versus open curative gastrectomy in early and advanced gastric cancer. methods: this was a retrospect ... | 2011 | 22011940 |
| agreement between semi-automatic radiographic morphometry and genant semi-quantitative method in the assessment of vertebral fractures. | semi-automatic morphometry is highly reproducible and not time intensive; however, no study has evaluated agreement between semi-automated morphometric methods and the genant semi-quantitative method performed as a rule by radiologists. our study shows substantial agreement between both methods; however, semi-automatic morphometry upgrades mild deformities and overestimates the prevalence of fractures. introduction: the aim of this st ... | 2011 | 22170523 |
| earthworms repair h2o2-induced oxidative dna adducts without removing uv-induced pyrimidine dimers. | ultraviolet (uv) radiation is a natural insult to various organisms. earthworms, although possessing similar biomolecules to those in mammalian skin, do not suffer from skin cancer nor any other types of cancer as humans do. however, little is known about the molecular mechanism of the earthworm's tolerance to uv. in this study, we evaluated the genotoxicity of uv and the capacity of earthworm cell to repair uv-induced damage. the t4 uv endonuclease uv-incorporated comet assay was used to examin ... | 2011 | 22021692 |
| meat quality of argentinean "camperos" chicken enhanced in omega-3 and omega-9 fatty acids. | five diets were assessed with the aim of increasing oleic fatty acid and omega-3 polyunsaturated fatty acid content in 'campero' poultry meat and evaluating their influence on sensory attributes. animals from treatment 1 (t1) were confined and fed with corn/soybean diet; in t2, animals were fed with a corn/soybean mix with free access to pasture; t3 diet had high oleic sunflower seeds (hoss) and linseeds with access to pasture; t4 diet was similar to t2 with free access to chicory instead of pas ... | 2008 | 22062903 |
| Thoracoscopic excision of the sympathetic chain: an easy and effective treatment for hyperhidrosis in children. | BACKGROUND: Thoracoscopic sympathectomy (TS) is an effective treatment for hyperhidrosis. Various surgical approaches are described in the literature. We describe the technique of thoracoscopic excision of the sympathetic chain done exclusively in children younger than 13 years. METHODS: All patients younger than 13 years who underwent TS from 2006 at a single institution were prospectively identified and fully e ... | 2011 | 21960313 |
| Chemoradiation for patients with large-volume laryngeal cancers. | BACKGROUND: Patients with T4 laryngeal cancers, including those with large-volume (cartilage or tongue-base invasion) lesions, are often excluded from organ-preservation trials due to expectations of inferior outcome in terms of survival and function. We hypothesize that such patients indeed have acceptable survival and function when treated with organ-preservation strategies. METHODS: Retrospective analysis of prospectively collected data of a cohort of patients with T4 laryngeal cancer was car ... | 2011 | 22052816 |
| A homing endonuclease and the 50-nt ribosomal bypass sequence of phage T4 constitute a mobile DNA cassette. | Since its initial description more than two decades ago, the ribosome bypass (or "hop") sequence of phage T4 stands out as a uniquely extreme example of programmed translational frameshifting. The gene for a DNA topoisomerase subunit of T4 has been split by a 1-kb insertion into two genes that retain topoisomerase function. A second 50-nt insertion, beginning with an in-phase stop codon, is inserted near the start of the newly created downstream gene 60. Instead of terminating at this stop codon ... | 2011 | 21930924 |
| Activity of some physiological modulators in reducing the side effects of levothyroxine in patients suffering from primary hypothyroidism. | The use of L-T4 (levothyroxine) in the treatment of primary hypothyroidism causes oxidative stress (OS) and daily discomfort. It is believed that the use of physiological modulators (PMs) may make the treatment more tolerable. | 2011 | 22108485 |
| Diffusion of bacteriophages through artificial biofilm models. | The simple two-chamber diffusion method was improved to study the diffusion properties of bacteriophage (phage) T4 through a model biofilm agarose gel membrane (AGM) embedded with dead host Escherichia coli K12 cells. The apparent diffusion coefficient (D(app) ) of phage T4 was calculated to be 2.4 × 10(-12) m(2) /s in 0.5% AGM, which was lower than the coefficient of 4.2 × 10(-12) m(2) /s in 0.5% AGM without host cells. The phage adsorption process by dead host cells slowed the apparent phage ... | 2011 | 22058083 |
| Ferrocene-functionalized SWCNT for electrochemical detection of T4 polynucleotide kinase activity. | A novel electrochemical strategy for monitoring the activity and inhibition of T4 polynucleotide kinase (PNK) is developed by use of titanium ion (Ti(4+)) mediated signal transition coupled with signal amplification of single wall carbon nanotubes (SWCNTs). In this method, a DNA containing 5'-hydroxyl group is self-assembled onto the gold electrode and used as substrate for PNK. The biofunctionalized SWCNTs with anchor DNA and ferrocene are chosen as the signal indicator by virtue of the intrins ... | 2011 | 22209074 |
| transgenic rice plants harboring the grain hardness-locus region of aegilops tauschii. | grain hardness of wheat is determined by the hardness (ha)-locus region, which contains three friabilin-related genes: puroindoline-a (pina), puroindoline-b (pinb) and gsp-1. in our previous study, we produced the transgenic rice plants harboring the large genomic fragment of the ha-locus region of aegilops tauschii containing pina and gsp-1 genes by agrobacterium-mediated transformation. to examine the effects of the transgenes in the rice endosperms, we firstly confirmed the homozygosity of th ... | 2011 | 21850595 |
| Early pospartum alexithymia and risk for depression: Relationship with serum thyrotropin, free thyroid hormones and thyroid autoantibodies. | Most psychometric evaluations in the postpartum (PP) target depression (PPD) and show an association with thyroid autoantibodies (TAb), not with thyroid function. Three studies evaluated PP alexithymia, but none its relationship with thyroid indices. We tested 74 women aged 31.8±4.64 years, on day 3 PP, by the Edinburgh Postnatal Depression Scale (EPDS), the Montgomery and Asberg Depression Rating Scale (MADRS), and the Toronto Alexithymia Scale (TAS). Concurrently, we measured serum thyrotropin ... | 2011 | 22047958 |
| validation of the 2009 tnm classification for renal cell carcinoma: comparison with the 2002 tnm classification by concordance index. | to assess the validity of the 2009 tnm classification for renal cell carcinoma (rcc) and compare its ability to predict survival relative to the 2002 classification. | 2011 | 21927698 |
| Real-time PCR for the detection of precise transgene copy number in durum wheat. | Recent results obtained in various crops indicate that real-time PCR could be a powerful tool for the detection and characterization of transgene locus structures. The determination of transgenic locus number through real-time PCR overcomes the problems linked to phenotypic segregation analysis (i.e. lack of detectable expression even when the transgenes are present) and can analyse hundreds of samples in a day, making it an efficient method for estimating gene copy number. Despite these advanta ... | 2011 | 21922222 |
| P-selectin, E-selectin, and CD40L over time in chronic hemodialysis patients. | The aim of this study was to measure P-selectin, E-selectin, and CD-4L levels over time in chronic hemodialysis (HD) patients. Thirty stable patients with end-stage renal failure undergoing chronic HD were included in the study. Blood samples were obtained before HD for measurement of P-selectin, E-selectin, and CD-40L. Measurements were performed at month 0 (T0), 3 (T2), 8 (T3), and 13 (T4). The levels of P-selectin, E-selectin, and CD40L were also analyzed according to the occurrence of cardio ... | 2011 | 22099468 |
| in vivo delivery of nucleic acids via glycopolymer vehicles affords therapeutic infarct size reduction in vivo. | using a new class of nontoxic and degradable glycopolymer-based vehicles termed poly(glycoamidoamine)s, we demonstrate virus-like delivery efficacy of oligodeoxynucleotide (odn) decoys to cardiomyoblasts (h9c2), primary cardiomyocytes, and the mouse heart. these glycopolymers bind and compact odn decoys into nanoparticle complexes that are internalized by the cell membrane and mediate nuclear uptake of dna in 90+% of cultured primary cardiomyocytes and 87% of the mouse myocardium. experimental r ... | 2011 | 22186793 |
| [Effects of incretion hormones on growth pituitary adenoma ectomy and evaluation of long-term therapeutic efficacy]. | To investigate the effect of incretion hormones on growth pituitary adenoma ectomy patients and evaluate its long-term therapeutic efficacy. | 2011 | 22094038 |
| Significance of histological prostatitis in patients with urinary retention and underlying benign prostatic hyperplasia or adenocarcinoma of the prostate. | What's known on the subject? and What does the study add? It is known that histological prostatitis is associated with a significantly higher risk for acute urinary retention in men with BPH. This study showed that, in men with BPH, histological prostatitis was associated with urinary retention at a significantly younger age and with higher serum PSA levels. In men with ACP, histological prostatitis was associated with urinary retention at an earlier stage of cancer. Study Type - Prognosis (indi ... | 2011 | 21851551 |
| Postmenopausal women with osteoporosis and musculoskeletal status: a comparative cross-sectional study. | With increased life expectancy of the world's population that has taken place in recent decades, there has been growth in the incidence of illnesses of the most advanced ages, including osteoporosis. However, changes in musculoskeletal disorders are not yet so clear. This study proposes to evaluate musculoskeletal alterations in osteoporotic postmenopausal women and healthy and correlate with bone mineral density of the lumbar spine. | 2011 | 22121400 |
| The effect of the intravenous phenylephrine on the level of spinal anesthesia. | Spinal anesthesia causes hypotension and bradycardia due to sympathetic nerve block and it is difficult to predict the level of sensory block and the duration of blockade. Recent studies have reported that intravenous phenylephrine can reduce the rostral spread of spinal anesthesia in pregnant women. We think a phenylephrine infusion will be useful for maintaining the baseline blood pressure by reducing the rostral spread of spinal anesthesia during the elective surgery of non-obstetric patients ... | 2011 | 22148084 |
| rapid genetic characterization of a novel enterobacteria phage and determination of its host recognizing genes. | we isolated a novel enterobacteria phage ime08 from hospital sewage, then confirmed it was a double-stranded dna phage by digesting its genetic material with dnase i, rnase a and several restriction endonucleases respectively. blast results of random fragments generated by a random pcr cloning method revealed that it belonged to t4-like virus. we subsequently determined the host recognizing genes (g37 and g38) sequence with a pcr-based "genome jumping" protocol based on highly conserved region a ... | 2011 | 22034817 |
| rubinstein-taybi syndrome with scoliosis. | abstract: | 2011 | 21961764 |
| molecular determinants of hiv-2 r5-x4 tropism in the v3 loop: development of a new genotypic tool. | objective. the use of ccr5 inhibitors requires a tool to predict human immunodeficiency virus type 2 (hiv-2) tropism, as established in hiv-1. the aim of our study was to identify genotypic determinants of hiv-2 tropism located in the gp105 v3 loop. methods. hiv-2 tropism phenotypic assays were performed on 53 hiv-2 clinical isolates using gfp expressing human osteosarcoma t4 [ghost(3)] cell lines expressing cd4 and ccr5 or cxcr4 coreceptors. the gp105 v3 loop was sequenced and analyzed. results ... | 2012 | 22140264 |
| Sensitive and rapid screening of T4 polynucleotide kinase activity and inhibition based on coupled exonuclease reaction and graphene oxide platform. | Phosphorylation of DNA with 5'-hydroxyl termini plays a critical role in a majority of normal cellular events, including DNA recombination, DNA replication, and repair of DNA during strand interruption. Determination of nucleotide kinase activity and inhibition is under intense development due to its importance in regulating nucleic acid metabolism. Here, by using T4 polynucleotide kinase (PNK) as a model, which plays an essential role in cellular nucleic acid metabolism, particularly in the cel ... | 2011 | 22026510 |
| increased frequency of follicular helper t cells in patients with autoimmune thyroid disease. | context:follicular helper t (tfh) cells exert an important role in the autoimmune diseases.aim:our study aimed to explore the role of tfh cells in patients with autoimmune thyroid disease (aitd).design:tfh cell is a new subset regulating the antibody production of b cell. previous studies implicated cd4(+)cxcr5(+)icos(high) or cd4(+)cxcr5(+)pd-1(high) as the markers of circulating tfh cells. sixty-five patients with aitd and 30 healthy controls were enrolled in the current study. the percentages ... | 2011 | 22188745 |
| serum hormone and biochemical activity as biomarkers of mercury toxicity in the yellowfin seabream acanthopagrus latus. | this study was undertaken in two separate environmental and experimental conditions. the environmental test was carried out at creeks in the persian gulf and the experimental test was undertaken in seawater re-circulatory tanks. mercury concentrations were determined using a standard cold vapour atomic absorption method. serum enzymes were determined with diagnostics infinity reagent kit. serum glucose and total protein were measured photometrically. serum hormones were assayed using diagnostic ... | 2011 | 21911425 |
| central neuropeptide y infusion and melanocortin 4 receptor antagonism inhibit thyrotropic function by divergent pathways. | weight loss inhibits thyrotropic function and reduces metabolic rate, thereby contributing to weight regain. under negative energy balance there is an increase in the hypothalamic expression of both neuropeptide y (npy) and agouti related peptide (agrp), the endogenous antagonist of melanocortin 4 (mc4) receptors. both npy and mc4 receptor antagonism reduce thyrotropic function centrally, but it is not known whether these pathways operate by similar or distinct mechanisms. we compared the time-c ... | 2011 | 21862125 |
| dynamics of friendship networks and alcohol use in early and mid-adolescence. | similarity in alcohol consumption among adolescent friends could be caused by the influence of friends or by the selection of friends who consume similar levels of alcohol. this article aims to disentangle influence and selection processes while specifically examining changes over time in these processes and possible differences between reciprocal and nonreciprocal friendships. | 2012 | 22152667 |
| Central hypothyroidism. | Central hypothyroidism is defined as hypothyroidism due to insufficient stimulation by thyroid stimulating hormone (TSH) of an otherwise normal thyroid gland. It has an estimated prevalence of approximately 1 in 80,000 to 1 in 120,000. It can be secondary hypothyroidism (pituitary) or tertiary hypothyroidism (hypothalamus) in origin. In children, it is usually caused by craniopharyngiomas or previous cranial irradiation for brain tumors or hematological malignancies. In adults, it is usually due ... | 2011 | 21966662 |
| impact of histological response after neoadjuvant chemoradiotherapy on recurrence-free survival in uicc-t3 pancreatic adenocarcinoma but not in uicc-t4. | although the prognostic benefit of neoadjuvant chemoradiotherapy (ncrt) against pancreatic cancer has been indicated by several reports, it is controversial whether histological response is associated with prognosis. the objective was to explore the relationship between histological response and prognosis in t3 and t4 pancreatic adenocarcinoma. | 2012 | 21934551 |
| utilisation of iodine from different sources by sows and their progeny. | the aim of the study was to compare iodine utilization from different sources by sows and their progeny and the levels of t3 and t4 in their serum. | 2011 | 21876486 |
| the force-velocity relationship of paralyzed quadriceps muscles during functional electrical stimulation cycling. | objectives. to investigate the nature of the force-velocity relationship on muscle forces and power outputs during functional electrical stimulation (fes)-evoked cycling at different pedaling cadences. materials and methods. ten patients with t4-t9 spinal cord injuries (asia a) performed fes-evoked cycling at 50 rev/min using a motorized isokinetic ergometer for 20 min, after which quadriceps crank torque and power were measured at 10, 30, and 50 rev/min. results. pedal cadence affected both ... | 2007 | 22151814 |
| the effect of nitroglycerin on hemodynamic changes during laparoscopic low anterior resection. | more laparoscopic low anterior resections (lar) are being performed in recent years. there has been controversy around the hemodynamic changes affected by the trendelenburg position and pneumoperitoneum during lar. the goal of this study was to analyze the effect of nitroglycerin (ntg) on hemodynamic changes during lar. | 2011 | 22148087 |
| human equilibrative nucleoside transporter 1 expression is a strong independent prognostic factor in uicc t3-t4 pancreatic cancer patients treated with preoperative gemcitabine-based chemoradiotherapy. | background/purpose: we aimed to determine the relationship between the intratumoral expression of human equilibrative nucleoside transporter (hent1), the main gemcitabine transporter into cells, and the outcome of gemcitabine-based chemoradiotherapy (gem-crt) in patients with international union against cancer (uicc) t3-t4 pancreatic adenocarcinoma. methods: the expressions of hent1, thymidylate synthase (ts), and dihydropyrimidine dehydrogenase were immunohistochemically analyzed using the rese ... | 2011 | 21898089 |