| tonsillar metastasis of gastric cancer. | metastasis from a malignant tumor to the palatine tonsils is rare, with only 100 cases reported in the english-language literature. tonsillar metastasis from a gastric cancer is very rare. we report here a case of palatine tonsillar metastasis after gastric cancer surgery. the patient was an 88-year-old woman who had gastric cancer with abdominal wall invasion. she had undergone a distal gastrectomy with abdominal wall resection and d2 lymph node dissection. histologically, the tumor was primari ... | 2010 | 21841958 |
| natural course of insomnia comorbid with cancer: an 18-month longitudinal study. | purpose this study aimed to assess the prevalence and natural course (incidence, persistence, remission, and relapse) of insomnia comorbid with cancer during an 18-month period. patients and methods all patients scheduled to receive a curative surgery for a first diagnosis of nonmetastatic cancer were approached on the day of their preoperative visit to participate in the study. a total of 962 patients with cancer (mixed sites) completed an insomnia diagnostic interview at the perioperative phas ... | 2011 | 21825267 |
| recombinant marker allergens in diagnosis of patients with allergic rhinoconjunctivitis to tree and grass pollens. | the aim of this study was to investigate recombinant marker allergens in patients with allergic rhinoconjunctivitis to tree and grass pollens. | 2011 | 21711974 |
| two new ternary complexes of copper(ii) with tetracycline or doxycycline and 1,10-phenanthroline and their potential as antitumoral: cytotoxicity and dna cleavage. | this paper reports on the synthesis and characterization of two new ternary copper(ii) complexes: [cu(doxycycline)(1,10-phenanthroline)(h(2)o)(clo(4))](clo(4)) (1) and [cu(tetracycline)(1,10-phenanthroline)(h(2)o)(clo(4))](clo(4)) (2). these compounds exhibit a distorted tetragonal geometry around copper, which is coordinated to two bidentate ligands, 1,10-phenanthroline and tetracycline or doxycyline, a water molecule, and a perchlorate ion weakly bonded in the axial positions. in both compound ... | 2011 | 21692452 |
| comparison of clinical and pathologic findings of prostate cancers detected through screening versus conventional referral in brazil. | introduction: data regarding prostate cancer screening in brazil are limited. we compared features of prostate cancers detected through screening versus those referred for treatment in brazil. patients and methods: group i included 500 of 13,754 men whose cancers were detected through screening, and group ii included 2731 men referred for treatment through the habitual public health system. we used mann-whitney and ¤ç(2) tests to compare clinical and pathologic findings, considering significant ... | 2011 | 21843976 |
| microrna signature analysis in colorectal cancer: identification of expression profiles in stage ii tumors associated with aggressive disease. | purpose: colorectal cancer (crc) is a clinically diverse disease whose molecular etiology remains poorly understood. the purpose of this study was to identify mirna expression patterns predictive of crc tumor status and to investigate associations between microrna (mirna) expression and clinicopathological parameters. methods: expression profiling of 380 mirnas was performed on 20 paired stage ii tumor and normal tissues. artificial neural network (ann) analysis was applied to identify mirnas pr ... | 2011 | 21739196 |
| thyroid disease in older people. | several changes in thyroid hormone secretion, metabolism, and action occur with the increase in age. aging is often associated with a decrease in serum thyroid stimulating hormone and t3 levels, whereas serum free t4 levels usually remain unchanged. the prevalence of thyroid dysfunction is higher in the elderly as compared to the younger population. in elderly individuals the non-specific clinical manifestations of thyroid hormone excess or deprivation can cause confusion in the clinical setup; ... | 2011 | 21719219 |
| effect of substituting live feed with formulated feed on the reproductive performance and fry survival of siamese fighting fish, betta splendens (regan, 1910). | this study aimed to elucidate the effect of partial or complete replacement of live feed (lf) (tubifex) with formulated feed (ff) on the reproductive performance of betta splendens. three hundred b. splendens fry (average weight 0.19-á-¦-á0.01-ág) were equally distributed into five different groups, each with three replicates. they were fed for 105-ádays with following different diets: control (c)-100% lf; t1-75% lf, 25% ff; t2-50% lf, 50% ff; t3-25% lf, 75% ff, and t4-100% ff. results showed th ... | 2011 | 21710171 |
| flurbiprofen axetil enhances analgesic effect of fentanyl associated with increase in +¦-endorphin levels. | purpose: to examine the analgesic effect of preoperative administration of flurbiprofen axetil and that of postoperative administration of a combination of flurbiprofen axetil and fentanyl, as well as perioperative plasma +¦-endorphin (+¦-ep) levels in patients undergoing esophagectomy. methods: forty-five patients were randomly divided into three groups: group a: 100-ámg flurbiprofen axetil preoperative, 10-á++g/kg fentanyl-á+-á10-áml placebo postoperative; group b: 100-ámg flurbiprofen axetil ... | 2011 | 21725634 |
| stretching dna in polymer nanochannels fabricated by thermal imprint in pmma. | we present results regarding the fast and inexpensive fabrication of polymer biochips for investigating the statics and dynamics of dna confined in nanochannels. the biochips have been fabricated by means of nanoimprint lithography (nil) in low molecular weight polymethyl methacrylate (pmma) using a 4-áinch diameter two-level hybrid stamp. the fluidic structures were sealed using thermal polymer fusion bonding. the stamp has nanometer--áand micrometer-sized protrusions defined in a thermally gro ... | 2008 | 21817722 |
| the effect of trauma on stress reactivity in aggressive youth. | to address gaps in the literature related to the contribution of childhood trauma on aggression we evaluated salivary cortisol and heart rate changes to psychological challenge in aggressive children with various degrees of trauma. we hypothesized that traumatized and aggressive youths will exhibit higher responsiveness to an active challenge (violent film-vf) than aggressive youth with no trauma but will not differ when viewing a non-violent film (nvf). a total of 25 children (aged 9-12; m=15, ... | 2011 | 21684014 |
| seom clinical guidelines for the treatment of invasive bladder cancer. | the purpose of this article is to provide updated recommendations for the diagnosis and treatment of muscle- invasive and metastatic bladder cancer. the diagnosis of muscle-invasive bladder cancer is made by transurethral resection and following histopathologic evaluation. invasive bladder cancer should be staged according to the uicc system. patients with confirmed muscle-invasive bladder cancer should be staged by computed tomography scans of the chest, abdomen and pelvis. radical cystectomy i ... | 2011 | 21821489 |
| morphologic evaluation of the thoracic vertebrae for safe free-hand pedicle screw placement in adolescent idiopathic scoliosis: a ct-based anatomical study. | objective: to evaluate the morphologic characteristics of the thoracic pedicle with regard to safe free-hand thoracic pedicle screw placement, based on multi-planar reconstruction ct images. methods: thirty adolescent idiopathic scoliosis (ais) patients who had undergone posterior corrective surgery for major thoracic curve were included in this study. reconstructed ct axial images at each thoracic vertebra were used to measure: (1) the shortest distance from an entry point to the ventral cortex ... | 2011 | 21739245 |
| zoster myelitis in sickle cell anemia. | a 17-year-old female patient, known case of sickle cell anemia was admitted to our hospital with 10 days history of fever, vomiting, and epigastric pain. on examination, her temperature was 38-¦c. there was a vesicular type of rash below the nipple and over the left chest involving the back. she was diagnosed as herpes zoster and was started on acyclovir with good hydration and analgesia. three days later, she developed weakness and decreased sensation of the right leg. on the fifth day, examina ... | 2011 | 21677622 |
| [clinical significance of radical cystectomy with extended lymphadenectomy]. | to evaluate the prognosis of patients treated with radical cystectomy and extended lymphadenectomy for invasive bladder cancer and to describe the association of the primary bladder tumor grade, stage, lymph node status and lymph node density with clinical outcomes. | 2011 | 21844970 |
| thyroid hormone regulation by stress and behavioral differences in adult male rats. | thyroid hormones are essential regulators of growth, development and normal bodily function and their release is coordinated by the hypothalamic-pituitary-thyroid (hpt) axis. while the hpt axis has been established as an acutely stress-responsive neuroendocrine system, relatively little is known about the mechanisms of its stress regulation. the present study examined acute stress-induced changes in peripheral hormone levels [triiodothyronine (t3); thyroxine (t4), thyroid-stimulating hormone (ts ... | 2011 | 21689656 |
| mental adjustment to cancer and its relation to anxiety, depression, hrql and survival in patients with laryngeal cancer - a longitudinal study. | using a longitudinal design, aim of this study was to investigate the relation between mental adjustment to cancer and anxiety, depression, health-related quality of life (hrql) and survival in patients treated for laryngeal cancer. | 2011 | 21718478 |
| overexpression of sirt1 in mouse forebrain impairs lipid/glucose metabolism and motor function. | sirt1 plays crucial roles in glucose and lipid metabolism, and has various functions in different tissues including brain. the brain-specific sirt1 knockout mice display defects in somatotropic signaling, memory and synaptic plasticity. and the female mice without sirt1 in pomc neuron are more sensitive to diet-induced obesity. here we created transgenic mice overexpressing sirt1 in striatum and hippocampus under the control of camkii+¦ promoter. these mice, especially females, exhibited increas ... | 2011 | 21738790 |
| +ñhyroid storm induced by trauma due to spear-fishing gun trident impaction in the neck. | a rare case of thyroid storm induced by thyroid gland injury because of penetrating neck trauma is reported. the injury was the result of a spear-fishing gun trident impaction in the neck. the diagnosis of thyroid gland injury was suspected by preoperative clinical examination and established during neck exploration in the theatre. the gland injury led to thyroid storm owing to the rupture of acini and liberation of thyroxine (t4) into the bloodstream. withdrawal of the impacted trident along wi ... | 2009 | 21709842 |
| the follow up of radioiodine treated hyperthyroid patients: should thyroid function be monitored more frequently? | background: there is a lack of data regarding the timing and particularly the severity of hypothyroidism post radioiodine (ri). aim: to investigate the timing and severity of hypothyroidism in ri treated hyperthyroid patients. methods: retrospective examination of the records of 183 ri treated hyperthyroid patients (79 patients autoimmune hyperthyroidism, 46 toxic mng and 58 hyperthyroidism of indeterminate aetiology). results: 159 patients requiring a single dose of ri (435 mbq), 107 (67%) deve ... | 2011 | 21720207 |
| metastatic potential in renal cell carcinomas ôëñ7cm: swedish kidney cancer quality register data. | background: renal cell carcinoma (rcc) represents 2-3% of all malignancies and accounts for approximately 90% of all kidney malignancies. an increasing proportion of rccs are discovered incidentally, and the average tumor diameter at diagnosis has decreased over the last few decades. small rccs have often been regarded by many as relatively harmless. objective: the objective was to evaluate the incidence of local t-category distribution and lymph node and distant metastases in relation to tumor ... | 2011 | 21741160 |
| levothyroxine monotherapy cannot guarantee euthyroidism in all athyreotic patients. | levothyroxine monotherapy is the treatment of choice for hypothyroid patients because peripheral t4 to t3 conversion is believed to account for the overall tissue requirement for thyroid hormones. however, there are indirect evidences that this may not be the case in all patients. | 2011 | 21829633 |
| type 2 deiodinase at the crossroads of thyroid hormone action. | thyroid hormone action can be customized on a cell-specific fashion through the controlled action of the deiodinase group of enzymes, which are homodimeric thioredoxin fold containing selenoproteins. whereas the type ii deiodinase (d2) initiates thyroid hormone signaling by activating the pro-hormone thyroxine (t4) to the biologically active t3 molecule, the type iii deiodinase (d3) terminates thyroid hormone action by catalyzing the inactivation of both t4 and t3 molecules. deiodinases play a r ... | 2011 | 21679772 |
| [vertical trapezius myocutaneous flap for repairing soft tissue defect after head and neck tumor resection]. | to introduce the experience of the clinical application of vertical trapezius myocutaneous flap in repairing soft tissue defects after head and neck tumor resection. | 2011 | 21675112 |
| correlation between plasma thyroid hormones and liver enzymes level in thyrotoxic cases and controls in hazara division. | thyrotoxicosis is defined as increased synthesis and secretion of thyroid hormones; when associated with defused goitre it is known as grave's disease. hepatic changes in thyrotoxiosis are fatty changes, cirrhosis and centrilobular necrosis, resulting in elevated serum levels of liver specific enzymes alt, ast and alk. objective of the study was to determine a correlation between plasma levels of 3 liver enzymes, and thyroid hormones in thyrotoxic cases, and matched controls in hazara division. | 2010 | 21702297 |
| exploring the roles of nucleobase desolvation and shape complementarity during the misreplication of o(6)-methylguanine. | o(6)-methylguanine (o(6)-meg) is a miscoding dna lesion arising from the alkylation of guanine. this report uses the bacteriophage t4 dna polymerase as a model to probe the roles of hydrogen-bonding interactions, shape/size, and nucleobase desolvation during the replication of this miscoding lesion. this was accomplished by using transient kinetic techniques to monitor the kinetic parameters for incorporating and extending natural and nonnatural nucleotides. in general, the efficiency of nucleot ... | 2011 | 21819995 |
| associations between polybrominated diphenyl ether (pbde) flame retardants, phenolic metabolites, and thyroid hormones during pregnancy. | background: polybrominated diphenyl ethers (pbdes) are chemical additives used as flame retardants in commercial products. pbdes are bioaccumulative, persistent, and have been linked to several adverse health outcomes. objectives: this study leverages an ongoing pregnancy cohort to measure pbdes, and pbde metabolites, in serum collected from an understudied population of pregnant women late in their third trimester. a secondary objective was to determine if the pbdes, or their metabolites, were ... | 2011 | 21715241 |
| rapid evolution of parental rdna in a synthetic tobacco allotetraploid line. | unidirectional gene conversion of rdna units has occurred in the evolution of natural tobacco (nicotiana tabacum). in this paper we report the use of the synthetic tobacco line th37, 4n (n. sylvestris +ù n. tomentosiformis), to study early rdna evolution associated with allopolyploidy. at least three classes of newly amplified rdna unit variants were identified (17/20 plants). their presence was often accompanied by near-complete elimination of n. tomentosiformis-donated rdna units (15/20 plants ... | 2003 | 21659197 |
| staged approach prevents spinal cord injury in hybrid surgical-endovascular thoracoabdominal aortic aneurysm repair: an experimental model. | in a porcine model, we investigated the impact of sudden stent graft occlusion of thoracic intercostal arteries after open lumbar segmental artery (sa) ligation. | 2011 | 21718839 |
| sustained control of graves' hyperthyroidism during long-term low-dose antithyroid drug therapy of patients with severe graves' orbitopathy. | background: patients with severe graves' orbitopathy often have hyperthyroidism that is difficult to treat and a high proportion of patients experience relapse of hyperthyroidism after a course of antithyroid drug (atd) therapy of fixed duration. the aim of the study was to evaluate the feasibility of prolonged low-dose atd therapy for attaining stable euthyroidism in patients with severe graves' orbitopathy and hyperthyroidism. methods: we performed retrospective analyses of data collected duri ... | 2011 | 21834677 |
| accelerated radiotherapy and concomitant high dose chemotherapy in non resectable stage iv locally advanced hnscc: results of a gortec randomized trial. | the objective was to evaluate the efficacy of a strong increase of the dose-intensity of concomitant radio-chemotherapy (rt-ct) in patients with far advanced non metastatic hnscc. | 2011 | 21831465 |
| neoadjuvant gemcitabine and cisplatin chemotherapy for locally advanced urothelial cancer of the bladder. | background: the purpose of this study was to investigate the effect of neoadjuvant chemotherapy with gemcitabine and cisplatin (gc) on pathologic down-staging of patients with locally advanced urothelial cancer (uc) of the bladder. methods: this was a retrospective cohort study of patients treated with radical cystectomy (rc) for clinical stage ct2-t4, n any, m0 bladder uc at strong memorial hospital from 1999 to 2009. the primary exposure variable was use of neoadjuvant chemotherapy (gc vs none ... | 2011 | 21720989 |
| apical-node metastasis in sigmoid colon or rectal cancer: is it a factor that indicates a poor prognosis after high ligation? | purpose: the prognostic significance of apical-node metastasis around the inferior mesenteric artery (ima) remains unclear. we investigated the oncological relevance of apical-node metastasis detected after high ligation of the ima in stage iii sigmoid colon or rectal cancer. methods: between may 2003 and december 2007, 229 consecutive patients with stage iii sigmoid colon or rectal cancer, who had undergone curative resection with high ligation, were analyzed. cox proportional regression model ... | 2011 | 21739197 |
| disseminated tumor cells predict survival after neoadjuvant therapy in primary breast cancer. | background: tumor cells that disseminate to the bone marrow (disseminated tumor cells [dtcs]) have been identified in 30% of patients with stage i through ii breast cancer (bc) and predict outcome. neoadjuvant chemotherapy (nact) is effective in reducing the size of primary tumors or eradicating lymph node metastases before surgery, but little is known regarding the presence or significance of dtcs after nact. methods: the authors evaluated dtcs in 95 patients with clinical stage i through iii b ... | 2011 | 21717428 |
| responses of growing japanese quails that received selenium from selenium enriched kale sprout (brassica oleracea var. alboglabra l.). | the objectives of this study were to determine the effect of selenium (se) from se-enriched kale sprout (brassica oleracea var. alboglabra l.) on the performance and se concentrations in tissues of growing japanese quails. two hundred quails were divided into five treatments. each treatment consisted of four replicates and each replicate contained ten quails in a completely randomize design. the experiment was conducted for 5-áweeks. the treatments were t1, control diet; t2, control diet plus 0. ... | 2011 | 21681467 |
| impact of severity, duration, and etiology of hyperthyroidism on bone turnover markers and bone mineral density in men. | abstract: background: hyperthyroidism is accompanied by osteoporosis with higher incidence of fracture rates. the present work aimed to study bone status in hyperthyroidism and to elucidate the impact of severity, duration, and etiology of hyperthyroidism on biochemical markers of bone turnover and bone mineral density (bmd). methods: fifty-two male patients with hyperthyroidism, 31 with graves' disease (gd) and 21 with toxic multinodular goiter (tng), with an age ranging from 23 to 65 years wer ... | 2011 | 21819612 |
| thyroid hormone transport in developing brain. | to discuss the recent advances on thyroid hormone transport in the brain. a special attention is paid to the x-linked thyroid hormone cell transport (thct) defect (also known as the allan-herndon-dudley syndrome), caused by mutations of the specific thyroid hormone transporter mct8 gene. | 2011 | 21825978 |
| lateral spine radiographs before androgen deprivation treatment detect a high incidence of undiagnosed vertebral fragility fractures in men with advanced prostate cancer. | baseline bone mineral density scanning in patients about to commence long-term androgen deprivation therapy for advanced/metastatic prostate cancer is reported to show a high incidence of osteoporosis and osteopenia. we investigated the incidence of existing spinal osteoporotic fractures in this population as this is known to be a risk factor for the development of treatment induced fractures. | 2011 | 21705031 |
| tranilast prevents the progression of chronic cyclosporine nephrotoxicity through regulation of transforming growth factor +¦/smad pathways. | our aim was to investigate the role of tranilast in transforming growth factor (tgf) +¦/smad pathways using a rat model of chronic cyclosporine (csa) nephrotoxicity. | 2011 | 21693312 |
| applicability of the pittsburgh staging system for advanced cutaneous malignancy of the temporal bone. | the objectives are to evaluate the applicability of the pittsburgh staging system (pss) (designed for primary temporal bone malignancies) to advanced periauricular cutaneous malignancies with temporal bone involvement and to study treatment outcomes and prognostic factors predicting recurrence-free survival. ten patients with advanced periauricular cutaneous malignancy with temporal bone involvement were identified. patients with primary temporal bone or parotid gland malignancies were excluded. ... | 2010 | 21772797 |
| the outcome of laparoscopic colorectal resection in t4 cancer. | aim:ôçé laparoscopic surgery for locally advanced tumours with extramural involvement is still controversial. it is believed that laparoscopic excision of t4 cancers is technically difficult and may result in prolonged operative time, increased conversion rate, added post-operative morbidity, and suboptimal oncological clearance. method:ôçé our unit has been practising laparoscopic colorectal surgery since 1992, and all data are entered into a database prospectively. since 1999 we have routinely ... | 2011 | 21689365 |
| thyroid function during critical illness. | the metabolic support of the critically ill patient is a relatively new target of active research and little is as yet known about the effects of critical illness on metabolism. the nonthyroidal illness syndrome, also known as the low t3 syndrome or euthyroid sick syndrome, describes a condition characterized by abnormal thyroid function tests encountered in patients with acute or chronic systemic illnesses. the laboratory parameters of this syndrome include low serum levels of triiodothyronine ... | 2011 | 21724536 |
| evaluation of effect of isoflavone on thyroid economy & autoimmunity in oophorectomised women: a randomised, double-blind, placebo-controlled trial. | the potential of soy isoflavones to interfere with thyroid function has been reported. however, there are limited data regarding their effect on thyroid function and autoimmunity in surgical menopausal women. the present study aimed to evaluate the effect of isoflavones on thyroid function and autoimmunity, menopausal symptoms, serum follicle stimulating hormone (fsh) and estradiol levels in oophorectomised women. | 2011 | 21727662 |
| acute psychotic episode in a patient with thyrotoxicosis factitia. | psychotic syndromes in the context of hyperthyroidism are seldom mentioned in medical textbooks and only a few cases have been published. typically, such cases present as an affective psychosis. schizophrenia-like psychosis is a rare occurrence in hyperthyroidism and the link between these two conditions is still poorly understood.we report the case of a female patient with a known history of chronic lymphocytic thyroiditis. the patient presented to our emergency department with an acute schizop ... | 2009 | 21686686 |
| predictive factors for pulmonary metastases after curative resection of rectal cancer without preoperative chemoradiotherapy. | the aim of this study was to clarify the actuarial incidence of pulmonary metastases and risk factors for pulmonary metastases after curative resection of rectal cancer without preoperative chemoradiotherapy. | 2011 | 21730788 |
| Disaster metrics: quantitative benchmarking of hospital surge capacity in trauma-related multiple casualty events. | Objectives:-á Hospital surge capacity in multiple casualty events (MCE) is the core of hospital medical response, and an integral part of the total medical capacity of the community affected. To date, however, there has been no consensus regarding the definition or quantification of hospital surge capacity. The first objective of this study was to quantitatively benchmark the various components of hospital surge capacity pertaining to the care of critically and moderately injured patients in tra ... | 2011 | 21685307 |
| Extent of lung resection in non-small lung cancer with interlobar lymph node involvement. | Optimal resection type for non-small cell lung cancer (NSCLC) with interlobar lymph node involvement (ILNI) has seldom been reported. To completely resect a NSCLC with ILNI, some surgeons believe that a pneumonectomy is needed. | 2011 | 21697782 |
| Insights into molecular properties of the human monocarboxylate transporter 8 by combining functional with structural information. | The monocarboxylate transporter 8 (MCT8) is a member of the major facilitator superfamily (MFS) and transports specificly iodothyronines. MCT8 mutations are the underlying cause of a syndrome of severe X-linked psychomotor retardation known as the Allan-Herndon-Dudley syndrome. This syndrome is characterized by abnormally high T3, low/normal T4 serum levels and slightly elevated serum TSH. To date, more than 25 pathogenic mutations in hMCT8 are known and they are valuable indicators of important ... | 2011 | 21835051 |
| Circumferential Resection Margin Involvement after Laparoscopic Abdominoperineal Resection for Rectal Cancer. | Aim:ÔÇé This study aimed to evaluate circumferential resection margin (CRM) involvement in patients with rectal adenocarcinoma after laparoscopic abdominoperineal resection (APR). Method:ÔÇé Prospectively collected data were analyzed on consecutive patients who underwent laparoscopic APR for histologically-proven rectal cancer following neoadjuvant chemotherapy from 1998 to 2006. Patients with no sphincter involvement were not included and underwent intersphincteric resection with coloanal anast ... | 2011 | 21689315 |
| the pharmacists' role in improving guideline compliance for thyroid function testing in patients with heart failure. | this single-center retrospective pilot program's objective was to utilize outpatient pharmacists to improve laboratory test adherence in chronic heart failure (chf) patients overdue for thyroid function testing, thereby demonstrating the value of the outpatient pharmacist and justifying possible clinical role expansion. thyroid disorders may contribute to chf development, progression, and exacerbation. testing is the standard of care in chf patients per american heart association's 2009 guidelin ... | 2011 | 21844214 |
| in vitro anticancer activity of the root, stem and leaves of withania somnifera against various human cancer cell lines. | withania somnifera dunal know as ashwagandha belong solanaceae family. it is extensively used in most of the indian herbal pharmaceuticals and nutraceuticals. the current study, evaluate in vitro cytotoxicity in 50% ethanol extract of root, stem and leaves of withania somnifera against five human cancer cell lines of four different tissues i.e. pc-3, du-145 (prostrate), hct-15 (colon), a-549 (lung) and imr-32 (neuroblastoma). root, stem and leaves extracts showed cytotoxicity activity ranging 0- ... | 2010 | 21695006 |
| bispectral monitoring in dogs subjected to ovariohysterectomy and anesthetized with halothane, isoflurane or sevoflurane. | to assess the effect of halothane (h), isoflurane (i) or sevoflurane (s) on the bispectral index (bis), and the effect of the addition of meperidine in dogs subjected to ovariohysterectomy. | 2011 | 21831053 |
| Resistant thyrotoxicosis in a patient with graves disease: a case report. | Background. Conventional management of thyrotoxicosis includes antithyroid drugs, radioactive iodine, and surgery while adjunctive treatment includes beta-blockers, corticosteroids, inorganic iodide and iopanoic acid. Very rarely, patients may be resistant to these modalities and require additional management. Case Presentation. A 50-year-old lady presented with weight loss and palpitations diagnosed as atrial fibrillation. Her past history was significant for right thyroid lobectomy for thyroto ... | 2011 | 21845211 |
| ED50 of Hyperbaric Bupivacaine With Fentanyl for Cesarean Delivery Under Combined Spinal Epidural in Normotensive and Preeclamptic Patients. | The use of reduced intrathecal doses is advised for spinal anesthesia during cesarean delivery. However, there are inadequate data regarding the minimum effective dose of intrathecal bupivacaine for cesarean delivery. Preeclampsia is caused by an endothelial dysfunction leading to generalized vasoconstriction. Whether this can offset the pregnancy-induced decrease in intrathecal dose requirement caused by epidural venous dilation and consequent thecal compression is not known. There are no data ... | 2012 | 22030721 |
| The evaluation of SOX9 expression and its relationship with carcinoembryonic antigen-related cell adhesion molecule 1 in gastric neoplastic and nonneoplastic lesions. | The aims of this study were to investigate the expression of SOX9 (sex determining region Y [SRY]-related high-mobility group box 9) and carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) in benign, premalignant, and malignant gastric lesions and to explore the association between SOX9 and CEACAM1 in gastric carcinogenesis. SOX9 and CEACAM1 expression was detected in normal gastric mucosa, hyperplastic polyp, intestinal metaplasia, gastric intraepithelial neoplasia, and adenocar ... | 2011 | 22209504 |
| Solution structure of a minor and transiently formed state of a T4 lysozyme mutant. | Proteins are inherently plastic molecules, whose function often critically depends on excursions between different molecular conformations (conformers). However, a rigorous understanding of the relation between a protein's structure, dynamics and function remains elusive. This is because many of the conformers on its energy landscape are only transiently formed and marginally populated (less than a few per cent of the total number of molecules), so that they cannot be individually characterized ... | 2011 | 21857680 |
| oral maxillary squamous carcinoma: an indication for neck dissection in the clinically negative neck. | this multicenter study was undertaken to characterize the metastatic behavior of oral maxillary squamous carcinoma and to determine the role of selective neck dissection. | 2011 | 21990223 |
| impact of subclinical hypothyroidism treatment in systolic and diastolic cardiac function. | to evaluate the effects of levothyroxine (l-t4) replacement in echocardiographic parameters of middle-aged women with subclinical hypothyroidism (sh). | 2011 | 22147094 |
| Plasma progesterone, metabolic hormones and beta-hydroxybutyrate in Holstein-Friesian cows after superovulation. | Metabolic hormones [insulin, leptin, insulin-like growth factor-I (IGF-I), thyroxine (T4) and triiodothyronine (T3)], progesterone (P4) and beta-hydroxybutyrate (BHB) serum concentrations were evaluated and their effect on the superovulation results of donor cows was investigated in a semi-arid environment. Body weight, body condition score (BCS) and lactation stage were also included in the analysis. Twenty-three Holstein-Friesian cows were superovulated with 600 IU FSHp following the routine p ... | 2011 | 22079709 |
| thoracic paravertebral block for video-assisted thoracoscopic surgery: single injection versus multiple injections. | thoracic paravertebral blocks (pvbs) have been shown to be effective for analgesia after video-assisted thoracoscopic surgery (vats) with single- and multiple-injection techniques. the efficacy of single-injection pvb was compared with multiple-injection pvb on postoperative analgesia in vats was studied. | 2011 | 22055006 |
| effects of sitting up for five minutes versus immediately lying down after spinal anesthesia for cesarean delivery on fluid and ephedrine requirement; a randomized trial. | patient position after spinal anesthesia has had variable effects on blood pressure and ephedrine requirements. the aim of this study was to determine the effects that sitting the patient up for five minutes after spinal anesthesia would have on intraoperative fluid and ephedrine requirements. | 2011 | 21971743 |
| treatment of chronic chest wall pain in a patient with loeys-dietz syndrome using spinal cord stimulation. | spinal cord stimulation (scs) has been used with increased frequency for the treatment of intractable pain including chronic chest pain. | 2011 | 21992158 |
| concomitant boost radiotherapy and multidrug chemotherapy in the neoadjuvant treatment of locally advanced rectal cancer: results of a phase ii study. | an intensified multidrug chemotherapy regimen (raltitrexed plus oxaliplatin, tom-ox) plus concomitant boost radiotherapy, in the neoadjuvant treatment of locally advanced rectal cancer patients, was shown feasible in our previous study. the aim of this study was to evaluate the efficacy in terms of pathologic complete response to pre-operative therapy. | 2011 | 21851185 |
| Prevalence of acanthamoeba from tap water in rio grande do Sul, Brazil. | A total of 136 samples of tap water were collected from state and municipal schools between March and November 2009. The samples were filtered through cellulose nitrate membranes that were seeded at non-nutrient agar 1.5% containing an overlayer of Escherichia coli suspension. Thirty-one (22.79%) tap water samples investigated were found positive for free-living amoebae (FLA). From these, 13 presented as FLA that seems to belong to the genus Acanthamoeba. All samples of FLA were cloned and ident ... | 2011 | 21882008 |
| Pilot study: individualized training for caregivers of hospitalized older veterans. | : The hospital-to-home transition represents a vulnerable time for older veterans who are more medically and socioeconomically challenged than the general population of older adults. | 2011 | 22067595 |
| Evaluation of hybrid treatments to produce high quality reuse water. | Four tertiary hybrid treatments to produce high quality reused water, fulfilling Brazilian drinking water regulations, from a slaughterhouse's secondary treated effluent were evaluated. The pilot plant with a capacity of 500 L h(-1) was set up and consisted of these stages: pre-filtration system (cartridge filter 50 micron, activated carbon filter, cartridge filter 10 micron), oxidation (H2O2) or second filtration (ceramic filter, UF) followed by UV radiation (90 L h(-1)). The best combination w ... | 2011 | 21902048 |
| Clinical nodal staging scores for bladder cancer: a proposal for preoperative risk assessment. | Radical cystectomy (RC) with pelvic lymph node dissection (LND) is the standard of care for refractory non-muscle-invasive and muscle-invasive bladder cancer. Although consensus exists on the need for LND, its extent is still debated. | 2012 | 22033174 |
| Phenothiourea sensitizes zebrafish cranial neural crest and extraocular muscle development to changes in retinoic acid and IGF signaling. | 1-Phenyl 2-thiourea (PTU) is a tyrosinase inhibitor commonly used to block pigmentation and aid visualization of zebrafish development. At the standard concentration of 0.003% (200 µM), PTU inhibits melanogenesis and reportedly has minimal other effects on zebrafish embryogenesis. We found that 0.003% PTU altered retinoic acid and insulin-like growth factor (IGF) regulation of neural crest and mesodermal components of craniofacial development. Reduction of retinoic acid synthesis by the pan-alde ... | 2011 | 21886774 |
| Soft tissue stability in segmental distraction of the anterior mandibular alveolar process. A 2-year follow-up. | This study evaluated soft tissue changes in adult patients treated with distraction osteogenesis (DOG) of the anterior mandibular alveolar process and related it to different parameters. 33 patients (27 females; 6 males) were analysed retrospectively before surgery at T1 (17.0 days), after surgery at T2 (mean 6.5 days), at T3 (mean 24.4 days), and at T4 (mean 2.0 years). Lateral cephalograms were traced by hand, digitized, superimposed, and evaluated. Statistical analysis was carried out using K ... | 2011 | 22204924 |
| A transgenic approach to identify thyroxine transporter-expressing structures in brain development. | Transporters are essential in thyroid hormone metabolism. Thyroxine (T4) is transported by solute carrier organic anion transporter 1c1 (SLCO1C1, OATP14) into the adult brain, where T4 is converted to 3,5,3'-triiodothyronine (T3). In adults, SLCO1C1 expression is found in two brain barrier structures: the blood-brain barrier (BBB) and choroid plexus. However, little is known about how T4 is transported in the developing brain, when the BBB is not yet completely formed. We employed bacterial arti ... | 2011 | 21910767 |
| microbial removal from the separated liquid fraction of anaerobically digested pig manure in meso-scale integrated constructed wetlands. | the aim was to investigate microbial removal from the liquid fraction of anaerobically digested pig manure in meso-scale integrated constructed wetlands (icw's) over a 13 month period. four treatments were investigated: t1 (standard), t2 (effluent recycling), t3 (high nutrient loading), and t4 (high flow rate). mean counts of yeasts and moulds and spore-forming bacteria were higher in t3 and t4 than in t1 and t2 (p<0.05). flow through the cells reduced mean counts of coliform, yeasts and moulds ... | 2011 | 21852121 |
| [type 1 diabetes impairs compensatory response after myocardial infarction; role of tissue hypothyroidism and effects of thyroid hormone administration]. | type 1 diabetes (tod) increases the risk of coronary artery disease and myocardial infarction and is characterized by baseline cardiac dysfunction. we investigated the influence of tod in post-infarct remodeling (rem) and the role of thyroid hormone (th) signaling in this response. acute myocardial infarction (ami) was induced in rats with type i diabetes (tod) and in non diabetic rats (ntod-ami), sham-operated rats serving as controls (sham). ami resulted in tissue hypothyroidism due to signifi ... | 2011 | 22039709 |
| metabolic pathways of tetraidothyronine and triidothyronine production by thyroid gland: a review of articles. | tetraidothyronine (t4) and triiodothyronine (t3) are the two vital hormones in human metabolism produced by thyroid gland. the major pathways in thyroid hormone biosynthesis begin with iodine metabolism which occurs in three sequential steps: active iodide transport into thyroid followed by iodide oxidation and subsequent iodination of tyrosyl residues of thyroglobulin (tg) to produce idotyrosines monoidotyrosine (mit) and diiodothyrosine (dit) on tg. oxidized iodine and tyrosyle residues which ... | 2011 | 21913492 |
| quantitative electroencephalography in schizophrenia and depression. | standard (qualitative) electroencephalography (eeg) is routinely used in the diagnostic evaluation of psychiatric patients. quantitative eeg (qeeg) findings differ between patients with schizophrenia, patients with depression, but results are not consistent. the aim of our study was to determine the differences in qeeg parameters between patients with schizophrenia, patients with depression, and healthy subjects. | 2011 | 22075736 |
| resolution of spam following cordectomy: implications for understanding pathophysiology. | study design:case report.objective:to describe the clinical benefit of a spinal cordectomy with the aim of limiting neurological deterioration related to the development of a subacute posttraumatic ascending myelopathy (spam) supporting previously described mechanism for spam formation.setting:national spinal injuries centre, stoke mandeville hospital, uk.method and results:a 38-year old patient presented 6 months after spinal cord injury substantial neurological deterioration expanding from the ... | 2011 | 22158252 |
| serum insulin-like growth factors and mortality in localised and advanced clinically detected prostate cancer. | many studies have reported associations of insulin-like growth factors (igfs) and igf-binding proteins (igfbps) with prostate cancer development, but none have investigated their association with fatal progression of prostate cancer. | 2011 | 22183619 |
| significance of mrna and protein expression of mac30 in progression of colorectal cancer. | background: meningioma-associated protein (mac30), first described to be overexpressed in meningiomas, exhibits altered expression in certain human tumors. the aim of our study was to investigate the expression of mac30 mrna and its correlation with clinicopathological variables in human colorectal cancer (crc). methods: mac30 mrna expression was first examined in 55 crcs, along with the samples from the matched distant normal and adjacent noncancerous tissue by rt-pcr, further verified in 18 cr ... | 2011 | 22024687 |
| Understanding narrative effects: the impact of breast cancer survivor stories on message processing, attitudes, and beliefs among African American women. | Examine the longitudinal effects of personal narratives about mammography and breast cancer compared with a traditional informational approach. | 2011 | 21895370 |
| Adverse Features on Rectal MRI Identify a High-risk Group that May Benefit from More Intensive Preoperative Staging and Treatment. | BACKGROUND: Magnetic resonance imaging (MRI) is highly accurate in local staging of rectal cancer. It can identify features known to be associated with increased risk of metastatic disease. We evaluated the incidence of synchronous metastatic disease on fludeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) and contrast-enhanced multiple-row detector computed tomography (ceMDCT) in MRI-stratified high- and low-risk rectal cancers. The aim was to determine the incidence of ... | 2011 | 21913017 |
| Sacropelvic Fixation With Iliosacral Screws: Applications and Results in Adult Spinal Deformities. | STUDY DESIGN:: Retrospective radiographic and clinical review. OBJECTIVE:: To determine the feasibility of iliosacral screw fixation in adult spinal deformations. SUMMARY OF BACKGROUND DATA:: Pelvic fixation is one of the most challenging instrumentation problems. The poor bone quality frequently found within the sacrum and the large lumbosacral loads with cantilever pullout forces across this region explain its frequent failure. METHODS:: Fourteen adult patients undergoing pelvic fixation using ... | 2011 | 22134734 |
| bilateral leg symptoms - the t10 syndrome? | prior studies have investigated the role of the sympathetic nervous system and the thoracic spine related to the upper extremities (known as the t4 syndrome). however, there is only little known about the role of the thoracic spine related to the lower extremities. in this case report, a patient with a heavy, tired feeling in both legs and hypomobile thoracic segments was treated with passive mobilisations of the thoracic spine. | 2011 | 21943505 |
| endothelial dysfunction and subclinical hypothyroidism : a brief review. | subclinical hypothyroidism (sh) is characterized by normal serum free t4 (ft4) and free t3 (ft3) levels and increased serum thyroid-stimulating hormone (tsh) levels. the relationship between sh and cardiovascular diseases has been one of the most popular topics recently. there is still some controversy concerning the cardiovascular impact of sh and management protocols. the vast majority of the studies so far published suggests that sh accelerates endothelial dysfunction through traditional effe ... | 2011 | 22186427 |
| outcome of opioid switching 4 weeks after discharge from a palliative care unit. | despite the favorable effects reported with opioid switching performed in a specialized unit in the short term, data on long-term basis are poor, particularly after discharging patients home or in other settings. research design and methods: the aim of this prospective study was to evaluate the long-term outcome of patients who were switched in an acute palliative care unit at a high volume of opioid switching. a consecutive sample of patients who underwent opioid substitution during admission i ... | 2011 | 22029619 |
| [advances of development of phage display systems]. | the phage display technology (pdt) was unique in genetic engineering and recombinant expression. the phage display systems (pds) were platforms (kits) composed of genetic modified phages, helper phages, and host bacteria. this review concisely summarized the development of four types of pds, based on m13, λ, t4, and t7 phages, in terms of phage molecular genetics and genetic (gene or genome) engineering. we addressed on the key components and their genetic (genomic) engineering for modifications ... | 2011 | 21993286 |
| Time course responses of serum GH, insulin, IGF-1, IGFBP1, and IGFBP3 concentrations after heavy resistance exercise in trained and untrained men. | To investigate the effect of heavy resistance exercise on IGF-1 system, 19 healthy trained men and 15 healthy untrained men volunteered to participate in this study. The subjects were randomly divided into experimental and control groups. Subjects of experimental groups were forced to perform a heavy resistance exercise with the intensity of 70-80% of 1RM in selected movements. The blood samples were taken from all subjects four times; before (T1), immediately after (T2), 5 (T3), and 8 (T4) hour ... | 2011 | 21983797 |
| Malignant melanoma in the elderly: different regional disease and poorer prognosis. | Purpose: Age is a poor prognostic factor in melanoma patients. Elderly melanoma patients have a different presentation and clinical course than younger patients. We evaluated the impact of age =70 years (yrs) on the diagnosis and natural history of melanoma.Methods: Retrospective review of 610 patients with malignant melanoma entered into a prospective sentinel lymph node (SLN) database, treated from June 1997 to June 2010. Disease characteristics and clinical outcomes were compared between pati ... | 2011 | 22084644 |
| Prognostic significance of breast cancer subtype and p53 overexpression in patients with locally advanced or high-risk breast cancer treated using upfront modified radical mastectomy with or without post-mastectomy radiation therapy. | BACKGROUND: Although post-mastectomy radiation therapy (PMRT) has shown benefits, its effects in patient subpopulations remain uncertain. Therefore, we assessed whether breast cancer subtype and p53 overexpression were associated with outcome after modified radical mastectomy (MRM), with or without PMRT. METHODS: We retrospectively analyzed the records of patients who underwent MRM, with or without PMRT, between January 1991 and December 2008. Patients were considered eligible if they had T3 or ... | 2011 | 21898181 |
| [A retrospective study about 11 cases of Esthesioneuroblastomas treated in Hospital Santa Creu i Sant Pau between 2000 and 2008 and literature review]. | INTRODUCTION. Esthesioneuroblastoma (ENB) is a very uncommon malignant tumor with a neuroectodermal origin that usually involves the anterior cranial fossa and nasal cavity. OBJECTIVES. To review our experience in the management of ENB and assess the validity of the histopathological diagnosis, modality of treatment and prognostic factors of the disease comparing our findings with the literature. METHODS. A retrospective study of 11 cases with the diagnosis of esthesioneuroblastoma treated in ou ... | 2011 | 22031159 |
| [A case of residual metastatic lymph node lesion following definitive chemoradiotherapy for t4 esophageal cancer, successfully treated by outpatient clinic-based sequential chemotherapy with docetaxel followed by s-1]. | Patients with T4 esophageal cancer generally have poor prognosis. Of these patients, prognosis of non-responder to chemoradiothrapy( CRT) is extremely poor. We report a case of residual lymph node metastasis following definitive CRT, which showed a good response to outpatient clinic-based chemotherapy consisting of docetaxel (DOC) followed by S-1 in a patient with T4 esophageal cancer. The patient was a 65-year-old man with the diagnosis of squamous cell carcinoma of the middle thoracic esophagu ... | 2011 | 22202394 |
| Retrospective evaluation of the use of amiodarone in dogs with arrhythmias (from 2003 to 2010). | Objectives: To evaluate the efficacy of amiodarone in dogs with refractory supraventricular and ventricular arrhythmias and to document the side effects in treated dogs. Methods: Records of 28 dogs were retrospectively searched to document indication for amiodarone administration, heart rate, alkaline phosphatase, alanine aminotransferase, thyroxine (T4) and thyroid stimulating hormone values before and after starting treatment and during follow-up periods. Results: Sixteen dogs with supraventri ... | 2011 | 22098072 |
| A rigid disulfide-linked nitroxide side chain simplifies the quantitative analysis of PRE data. | The measurement of (1)H transverse paramagnetic relaxation enhancement (PRE) has been used in biomolecular systems to determine long-range distance restraints and to visualize sparsely-populated transient states. The intrinsic flexibility of most nitroxide and metal-chelating paramagnetic spin-labels, however, complicates the quantitative interpretation of PREs due to delocalization of the paramagnetic center. Here, we present a novel, disulfide-linked nitroxide spin label, R1p, as an alternativ ... | 2011 | 21947919 |
| [Role of vascular endothelial active facters in gas exchange impairment induced by tourniquet and the effect of shenmai injection]. | To investigate the effect of Shenmai injection on vascular endothelial active facters nitric oxide (NO) and endothelin-1 (ET-1), and pulmonary gas exchange induced by tourniquet deflation in patients undergoing lower extremity surgery. | 2011 | 22066459 |
| Reversal of profound rocuronium or vecuronium-induced neuromuscular block with sugammadex in isoflurane-anaesthetised dogs. | This study evaluated the use of sugammadex for reversal of profound neuromuscular blockade induced with rocuronium or vecuronium in dogs. Anaesthesia was induced and maintained with isoflurane in oxygen in eight dogs on two occasions. Neuromuscular blockade was monitored using peroneal nerve stimulation and acceleromyography. Rocuronium 0.6mg/kg or vecuronium 0.1mg/kg was administered intravenously (IV), followed 5min later by sugammadex 8mg/kg IV. Lag and onset time of rocuronium and vecuronium ... | 2011 | 22030475 |
| Status of level IIb lymph nodes of the neck in squamous cell carcinoma of the oral tongue in patients who underwent modified radical neck dissection and lymph node sentinel biopsy. | Status of lymph nodes of level IIb was examined to identify the incidence of nodal metastasis and the lymphatic drainage in squamous cell carcinoma of the oral tongue in patients undergoing modified radical neck dissection (MRND) and sentinel node biopsy (SNB). Overall, 72 patients were divided into two groups; 38 patients (Group A) of any T and N+ or T3-T4- N0 stage underwent MRND. The surgical specimens were sent to the Pathology Department, divided into specific levels (I, IIa, IIb, III, IV, ... | 2011 | 22058590 |
| Subclinical hypothyroidism and its association with cardiovascular risk factors. | Subclinical hypothyroidism (SH) represents the mildest form of thyroid hormone deficiency and may be associated with adverse consequences [Subclinical hypothyroidism was defined as a TSH level > 4.0 mIU/L and a normal free thyroxine level 0.6-1.8 ng/dL]. The identification of patients with subclinical hypothyroidism having an increased cardiovascular risk (CVR) is important. The aim of the study was to evaluate atherosclerotic risk factors in patients with subclinical hypothyroidism. | 2011 | 22029187 |
| Statistical mechanics and molecular dynamics in evaluating thermodynamic properties of biomolecular recognition. | Molecular recognition plays a central role in biochemical processes. Although well studied, understanding the mechanisms of recognition is inherently difficult due to the range of potential interactions, the molecular rearrangement associated with binding, and the time and length scales involved. Computational methods have the potential for not only complementing experiments that have been performed, but also in guiding future ones through their predictive abilities. In this review, we discuss h ... | 2011 | 22082669 |
| characteristics of anemia in subclinical and overt hypothyroid patients. | thyroid hormones stimulate directly or indirectly growth of erythroid colonies through erythropoietin. anemia is often the first sign of hypothyroidism. hypothyroidism can cause a wide variety of anemic disorders. numerous mechanisms are involved in the pathogenesis of these anemias that can be microcytic, macrocytic and normocytic. we designed this study to investigate the anemia frequency and if present, etiology of anemia in hypothyroid patients. 100 patients with overt hypothyroid, 100 ... | 2011 | 22200582 |
| [The clinical effect of combination therapy for oral cancer with s-1, superselective intra-arterial chemotherapy, and radiation therapy]. | Combination therapy with S-1, superselective intra-arterial infusion of CBDCA and radiation therapy has been used to treat patients with oral cancer since 2005. In this study, the histopathological effects and toxicities following concurrent chemoradiotherapy were examined. The subjects consisted of 15 patients(10 men and 5 women)who were treated with S-1(60-80mg/day, 4 weeks), superselective intra-arterial infusion of CBDCA(300mg/body)and radiation therapy(total dose 30-36 Gy)in our department ... | 2011 | 22189221 |
| Alleviation of adverse effects of drought stress on growth and some potential physiological attributes in maize (Zea mays L.) by seed electromagnetic treatment. | Effects of varying preseed magnetic treatments on growth, chlorophyll pigments, photosynthesis, water relation attributes, fluorescence and levels of osmoprotectants in maize plants were tested under normal and drought stress conditions. Seeds of two maize cultivars were treated with different (T0 [0 mT], T1 [100 mT for 5 min], T2 [100 mT for 10 min], T3 [150 mT for 5 min] and T4 [150 mT for 10 min]) electromagnetic treatments. Drought stress considerably suppressed growth, chlorophyll a and b p ... | 2011 | 21883242 |
| focus on extralevator perineal dissection in supine position for low rectal cancer has led to better quality of surgery and oncologic outcome. | background: after abdominoperineal excision (ape), the presence of tumor cells in the circumferential resection margin (r1) and iatrogenic tumor perforations are still frequent and result in an increased rate of local recurrences. in this study, a standardized supine ape with an increased focus on the perineal dissection (sppd) is compared to the customary supine ape. methods: from 2000 to 2010, a total of 246 patients underwent ape for rectal cancer (sppd and customary supine ape). all patients ... | 2011 | 21861224 |