| clinicopathological outcomes after radical cystectomy for clinical t2 urothelial carcinoma: further evidence to support the use of neoadjuvant chemotherapy. | to evaluate the clinicopathological outcomes for patients with clinical t2 (ct2) urothelial carcinoma treated with radical cystectomy (rc) without neoadjuvant chemotherapy (nc). | 2011 | 20560950 |
| thyroid axis dysfunction in patients with prader-willi syndrome during the first 2 years of life. | prader-willi syndrome (pws) is a genetic disorder caused by the loss of expression of paternally transcribed genes in a highly imprinted region of chromosome 15q11-13. the clinical phenotype has been well characterized, mostly related to hypothalamic dysfunction. even though central hypothyroidism has been documented in 20-30% of patients with pws, thyroid function during the first 2 years of life has not been clearly defined. | 2010 | 20560980 |
| sacral neuromodulation in children with urinary and fecal incontinence: a multicenter, open label, randomized, crossover study. | the clinical benefit of sacral neuromodulation is unclear due to the paucity of randomized trial data. the purpose of this study was to evaluate sacral neuromodulation for management of urinary and fecal incontinence in a pediatric population. | 2010 | 20561645 |
| goitrogenic/antithyroidal potential of green tea extract in relation to catechin in rats. | catechins are flavonoids found in abundance in green tea, have elicited high interest due to their beneficial effects on health. though flavonoids have been reported to have an antithyroid effect and also to be goitrogenic there have been no reports about the effect of green tea on rat thyroid. the present study was designed to examine whether high doses of green tea has any harmful effect on thyroid physiology. for this purpose green tea extract was administered orally to male albino rats for 3 ... | 2010 | 20561943 |
| bacteriophage-based biosorbents coupled with bioluminescent atp assay for rapid concentration and detection of escherichia coli. | wild type t4 bacteriophage and recombinant t4 bacteriophages displaying biotin binding peptide (bccp) and cellulose binding module (cbm) on their heads were immobilized on nano-aluminum fiber-based filter (disruptor), streptavidin magnetic beads and microcrystalline cellulose, respectively. infectivity of the immobilized phages was investigated by monitoring the phage-mediated growth inhibition of bioluminescent e. coli b and cell lysis using bioluminescent atp assay. the results showed that pha ... | 2010 | 20561957 |
| polybrominated diphenyl ether (pbde) flame retardants and thyroid hormone during pregnancy. | human exposure to polybrominated diphenyl ether (pbde) flame retardants has increased exponentially over the last three decades. animal and human studies suggest that pbdes may disrupt thyroid function. although thyroid hormone (th) of maternal origin plays an essential role in normal fetal brain development, there is a paucity of human data regarding associations between exposure to pbdes and maternal th levels during pregnancy. | 2010 | 20562054 |
| laparoscopic colorectal surgery produces better outcomes for high risk cancer patients compared to open surgery. | the excellent outcomes reported for laparoscopic colorectal surgery in selected patients could also be potentially advantageous for high risk patients. this prospective study was designed to examine the feasibility and safety of laparoscopic resection in high risk patients with colorectal cancer. | 2010 | 20562603 |
| the bispectral electroencephalogram during modified electroconvulsive therapy under propofol anesthesia: relation with seizure duration and awakening. | implication statement:: use of the bispectral electroencephalogram during modified electroconvulsive therapy (mect) under propofol anesthesia was found to be an accurate predictor of seizure duration and awakening. this may have potential clinical implications on therapeutic success and elimination of the undesirable effects associated with this treatment modality. | 2010 | 20562643 |
| sewage bacteriophage inactivation by cationic porphyrins: influence of light parameters. | photodynamic therapy has been used to inactivate microorganisms through the use of targeted photosensitizers. although the photoinactivation of microorganisms has already been studied under different conditions, a systematic evaluation of irradiation characteristics is still limited. the goal of this study was to test how the light dose, fluence rate and irradiation source affect the viral photoinactivation of a t4-like sewage bacteriophage. the experiments were carried out using white par light ... | 2010 | 20563346 |
| identification of qtl associated with resistance to bacterial spot race t4 in tomato. | bacterial spot of tomato (solanum lycopersicum l.), caused by several xanthomonas sp., is a serious but difficult disease to control by chemical means. development of resistance has been hindered by emergence of races virulent to tomato, by the quantitative inheritance of resistance, and by a low correlation between seedling assays and resistance in the field. resistance to multiple races, including race t4, has been described in the s. lycopersicum var. cerasiformae accession pi 114490. we used ... | 2010 | 20563547 |
| molecular cloning and regulation of mrna expression of the thyrotropin β and glycoprotein hormone α subunits in red drum, sciaenops ocellatus. | full-length cdnas for thyrotropin β (tshβ) and glycoprotein hormone α (gsuα) subunits were cloned and sequenced from the red drum (sciaenops ocellatus). the cdnas for tshβ (877 bp) and gsuα (661 bp) yielded predicted coding regions of 126 and 94 amino acid proteins, respectively. both sequences contain all invariant cysteine and putative glycosylated asparagines characteristic of each as deduced by comparison with other gsuα and tshβ sequences from representative vertebrate species. multiple pro ... | 2010 | 20563882 |
| multifactorial, site-specific recurrence model after radical cystectomy for urothelial carcinoma. | a scoring algorithm of site-specific disease recurrence after cystectomy for urothelial carcinoma was designed. | 2010 | 20564121 |
| 2,3,7,8,12,13-hexaaryltruxenes: an ortho-substituted multiarm design and microwave-accelerated synthesis toward starburst macromolecular materials with well-defined pi delocalization. | we present herein a novel design and the efficient synthesis towards a "homogeneous" starburst fluorene system based on the novel 2,3,7,8,12,13-hexaaryltruxene scaffold. controlled microwave heating provides a facile and powerful approach for each step in the synthesis of these bulky materials with large steric hindrance, suggesting an avenue to access structurally well-defined complex organic semiconductors (oscs) rapidly and conveniently with high yield and purity. the resulting materials exhi ... | 2010 | 20564289 |
| accuracy of multidetector computed tomography in identifying poor prognostic factors in colonic cancer. | recent neoadjuvant strategies for high-risk colonic tumours have renewed interest in accurate preoperative staging. the aim of this study was to validate prospectively the accuracy of multidetector computed tomography (mdct) in stratifying patients into good and poor prognostic groups in a multicentre setting. | 2010 | 20564305 |
| factors associated with nonparticipation in one-year quality-of-life assessment in patients with head and neck squamous cell carcinoma. | to identify factors associated with nonparticipation in long-term quality-of-life (qol) analysis in head and neck squamous cell cancer (hnscc) patients. | 2010 | 20564472 |
| sequential chemoradiotherapy in advanced laryngeal cancer: an institutional experience. | the objective of this study was to determine the efficacy of sequential chemoradiation for larynx preservation. | 2010 | 20565422 |
| genetically engineered virulent phage banks in the detection and control of emergent pathogenic bacteria. | natural outbreaks of multidrug-resistant microorganisms can cause widespread devastation, and several can be used or engineered as agents of bioterrorism. from a biosecurity standpoint, the capacity to detect and then efficiently control, within hours, the spread and the potential pathological effects of an emergent outbreak, for which there may be no effective antibiotics or vaccines, become key challenges that must be met. we turned to phage engineering as a potentially highly flexible and eff ... | 2010 | 20569057 |
| overlap extension pcr cloning: a simple and reliable way to create recombinant plasmids. | here we describe a straightforward, efficient, and reliable way to clone an insert of choice into a plasmid of choice without restriction endonucleases or t4 dna ligase. chimeric primers containing plasmid sequence at the 5' ends and insert sequence at the 3' ends were used to pcr-amplify insertion sequences of various sizes, namely the genes for gfp (gfp), beta-d-glucuronidase (gusa), and beta-galactosidase (lacz), as well as the entire luxabcde operon. these inserts were employed as mega-prime ... | 2010 | 20569222 |
| intrathecal lactate concentration and spinal cord injury in thoracoabdominal aortic surgery. | the aim of this study was to evaluate the role of lactate as an early predictor of spinal cord injury during thoracoabdominal aortic aneurysm repair. | 2011 | 20570182 |
| molecular characterization and gene expression of thyrotropin-releasing hormone in senegalese sole (solea senegalensis). | we describe the cloning of a cdna encoding trh in solea senegalensis. phylogenetic analysis clustered it with other fish counterparts. eight conserved trh progenitors and highly divergent spacers were identified. expression profiles of trh were analyzed in juvenile tissues, during larval development, and in post-larvae grew under four photoperiods (12l:12d, 12d:12l, 24l:0d and 24d:0l) during four weeks using a real-time pcr approach. in juvenile fish, trh mrna was expressed ubiquitously although ... | 2010 | 20570750 |
| early-stage invasive breast cancers: potential role of optical tomography with us localization in assisting diagnosis. | to investigate the potential role of optical tomography in the near-infrared (nir) spectrum with ultrasonographic (us) localization as a means of differentiating early-stage cancers from benign lesions of the breast. | 2010 | 20571122 |
| effectiveness of neoadjuvant radiotherapy in the treatment of locally advanced rectal cancer: a single-center experience in 263 patients. | to determine the frequency of local recurrence (lr) and distant recurrence (dr) with 5-year survival analysis. | 2010 | 20571269 |
| effects of 14-week swimming training program on the psychological, hormonal, and physiological parameters of elite women athletes. | the purpose of the study was to investigate the influence of a 14-week swimming training program on psychological, hormonal, and performance parameters of elite women swimmers. ten olympic and international-level elite women swimmers were evaluated 4 times along the experiment (i.e., in t1, t2, t3, and t4). on the first day at 8:00 am, before the blood collecting at rest for the determination of hormonal parameters, the athletes had their psychological parameters assessed by the profile of mood- ... | 2011 | 20571443 |
| epirubicin and docetaxel as neoadjuvant treatment of locally advanced breast cancer: a phase ii study. | neoadjuvant chemotherapy is the standard treatment for locally advanced breast cancer. the combination of anthracyclines and taxanes is considered the first choice chemotherapy in advanced breast cancer. we report here the overall results of a phase ii study of epirubicin and docetaxel as neoadjuvant chemotherapy in advanced breast cancer. | 2010 | 20572578 |
| clinical features of primary hyperthyroidism caused by graves' disease admixed with resistance to thyroid hormone (p453t). | a 34-year-old japanese woman was referred to the hospital because of general fatigue and palpitations. she was diagnosed as having resistance to thyroid hormone (rth) and hashimoto's thyroiditis at the age of 28. she felt general fatigue, palpitations, heat intolerance, and sweating for 6 months. thyroid function tests demonstrated elevated levels of free triidothyronine (t3) and free thyroxine (t4) that were above detectable ranges and a completely suppressed level of tsh that was below the det ... | 2010 | 20574139 |
| the sunscreen agent 2-phenylbenzimidazole-5-sulfonic acid photosensitizes the formation of oxidized guanines in cellulo after uv-a or uv-b exposure. | the sunscreen agent 2-phenylbenzimidazole-5-sulfonic acid (pbsa) is water soluble and is widely used in the cosmetic industry because it absorbs strongly at uv-b wavelengths. previous studies have shown that pbsa, photoexcited by uv-b, oxidizes guanine bases in vitro. because of its potential phototoxic effect, it is important to determine whether pbsa photosensitizes in cellulo the formation of oxidatively generated dna damage on uv exposure. for this purpose, we investigated, in vitro and in c ... | 2010 | 20574440 |
| incremental effects of facemask therapy associated with intermaxillary mechanics. | to determine the dentofacial changes in children with skeletal class iii malocclusions treated with maxillary expansion, external maxillary protraction and intermaxillary traction. | 2010 | 20575205 |
| nasopharyngeal carcinoma: differences in presentation between different ethnicities in the new zealand setting. | there is an elevated incidence of nasopharyngeal carcinoma (npc) in the maori and pacific island (mpi) population as well as the asian population in new zealand; however, no studies have been conducted to evaluate how the two populations differ in their clinical presentation according to the tnm stage. | 2010 | 20575952 |
| postoperative residual curarization from intermediate-acting neuromuscular blocking agents delays recovery room discharge. | postoperative residual curarization (porc) [train-of-four ratio (t4/t1) <0.9] is associated with increased morbidity and may delay postoperative recovery room (pacu) discharge. we tested the hypothesis that postoperative t4/t1 <0.9 increases pacu length of stay. | 2010 | 20576632 |
| changes in temporomandibular joint disc position and form following herbst and fixed orthodontic treatment. | to determine the changes in the position and form of the temporomandibular joint articular disc in adolescents with class ii division 1 malocclusion and mandibular retrognathism treated with the herbst appliance (phase i) and fixed orthodontic appliance (phase ii). | 2010 | 20578854 |
| phylogenetic diversity of t4-like bacteriophages in lake baikal, east siberia. | among the tailed phages, the myoviruses, those with contractile tails, are widespread and diverse. an important component of the myoviridae family is the genus 't4-like viruses'. the present study was aimed at elucidating the molecular diversity of t4-type bacteriophages in lake baikal by partial sequencing of g23 genes of t4-type bacteriophages. our study revealed that the g23 gene sequences investigated were highly diverse and different from those of t4-like bacteriophages and from g23 clones ... | 2010 | 20579103 |
| is breast conservation therapy a viable option for patients with triple-receptor negative breast cancer? | triple-receptor negative breast cancers (tnbc) are aggressive neoplasms that lack estrogen-receptor, progesterone-receptor, and her-2 expressions. comparative analysis of breast conservation therapy (bct) versus mastectomy for tnbc is reported sparsely. we hypothesized that, despite its aggressive behavior, tnbc can be managed with bct. | 2010 | 20580045 |
| intestinal permeability enhancement of levothyroxine sodium by straight chain fatty acids studied in mdck epithelial cell line. | levothyroxine sodium (t4), administered orally, is used for the treatment of hypothyroidism. t4 is a narrow therapeutic index drug with highly variable bioavailability (40-80%). the purpose of the present study was to increase the transepithelial transport of t4 using straight chain fatty acids across madin-darby canine kidney (mdck) cell line. capric acid (c10), lauric acid (c12) and oleic acid (c18) were studied in molar ratios of 1:0.5, 1:1, 1:2 and 1:3 (t4:fatty acid). transport of the hydro ... | 2010 | 20580671 |
| effect of celecoxib combined with thoracic epidural analgesia on pain after thoracotomy. | thoracotomy results in severe postoperative pain potentially leading to chronic pain. we investigated the potential benefits of oral celecoxib on postoperative analgesia combined with thoracic epidural analgesia (tea). | 2010 | 20581214 |
| floating tablet of trimetazidine dihydrochloride: an approach for extended release with zero-order kinetics. | trimetazidine dihydrochloride is an effective anti-anginal agent; however, it is freely soluble in water and suffers from a relatively short half-life. to solve this encumbrance, it is a prospective candidate for fabricating trimetazidine extended-release formulations. trimetazidine extended-release floating tablets were prepared using different hydrophilic matrix forming polymers including hpmc 4000 cps, carbopol 971p, polycarbophil, and guar gum. the tablets were fabricated by dry coating tech ... | 2010 | 20582493 |
| prospective study of sexual dysfunction in men with rectal cancer: feasibility and results of nerve sparing surgery. | rectal cancer surgery is impaired by a high rate of postoperative sexual dysfunction cause of frequent nerve injuries. the aim of this study was to prospectively evaluate sexual function in a group of male patients after total mesorectal excision (tme) for rectal cancer, using an autonomic nerve sparing technique. | 2010 | 20582547 |
| does thyroid gland examination by palpation alter serum hormone levels? | the goal of this study was to investigate the effects of routine thyroid gland palpation on serum thyroid hormone levels. | 2010 | 20583234 |
| autoimmune thyroiditis and diabetes mellitus type 1 after long-term gonadotropin-releasing hormone agonist treatment for central precocious puberty: evolution or coincidence? | very few abnormalities in endocrine function have been reported during long term gonadotropin-releasing hormone agonist (gnrha) treatment in girls. most authors agree that this therapy is safe and effective. we present an unusual outcome of long term gnrha therapy in two girls with central precocious puberty(cpp) of idiopathic or organic origin. they have received monthly depot injections of triptorelin acetate for a time period of 8 years. thyroid function was examined by measuring serum levels ... | 2010 | 20583547 |
| cross-language perception of non-native tonal contrasts: effects of native phonological and phonetic influences. | this study examined the perception of the four mandarin lexical tones by mandarin-naïve hong kong cantonese, japanese, and canadian english listener groups. their performance on an identification task, following a brief familiarization task, was analyzed in terms of tonal sensitivities (a-prime scores on correct identifications) and tonal errors (confusions). the a-prime results revealed that the english listeners' sensitivity to tone 4 identifications specifically was significantly lower than t ... | 2010 | 20583732 |
| prevalence and pattern of nodal metastasis in pt4 gingivobuccal cancers and its implications for treatment. | the pattern of nodal spread in oral cancers is largely predictable and treatment of neck can be tailored with this knowledge. most studies available on the pattern are from the western world and for early cancers of the tongue and floor of the mouth. | 2010 | 20587912 |
| thoracic vertebral cavernous hemangioma in a schizophrenic patient--case report. | a 55-year-old man presented with gait disturbance, incontinence, and back pain. he had a medical history of schizophrenia for the past 35 years. computed tomography (ct) and magnetic resonance imaging suggested thoracic vertebral hemangioma. dynamic ct incidentally detected a hepatic hemangioma. laminectomy of t3 and t4, resection of the epidural hemangioma, and rigid instrumentation between t1 and t6 using rod and hook systems were performed. postoperatively, his symptoms completely disappeared ... | 2010 | 20587975 |
| effects of thoracic epidural analgesia on lower urinary tract function in women. | the need for an indwelling transurethral catheter in patients with postoperative thoracic epidural analgesia (tea) is a matter of controversy. subjective observations are ambivalent and the literature addressing this issue is scarce. as segmental blockade can be achieved with epidural analgesia, we hypothesized that analgesia within segments t4-t11 has no or minimal influence on lower urinary tract function. thus, we evaluated the effect of tea on lower urinary tract function by urodynamic studi ... | 2011 | 20589902 |
| efficacy of intrauterine lignocaine plus vaginal misoprostol for pain relief in premenopausal women undergoing endometrial aspiration and ambulatory hysteroscopy. | to compare the effectiveness of a combination of intrauterine lignocaine and vaginal misoprostol in reducing pain at hysteroscopy and endometrial aspiration (ea). | 2010 | 20590504 |
| reconstruction using free jejunal transfer after resection of cancer of the upper oesophagus. | treatment of cancer of the upper part of the oesophagus is challenging. even after intended curative treatment, less than half of the patients are alive after five years. this retrospective study evaluates all the patients who had the upper oesophagus reconstructed by use of a free jejunal transfer following cancer resection from february 2000 to may 2008 at the university hospital of aarhus. | 2010 | 20591339 |
| early avoidance of disease- and treatment-related distress predicts post-traumatic stress in parents of children with cancer. | purpose of the research: it has previously been demonstrated that parents of children with cancer often exhibit symptoms of post-traumatic stress (ptss) even though the child's treatment is successfully completed. for the development of interventions we need to identify predictors of ptss, which are possible to influence. based on contemporary learning theory, it was hypothesized that early avoidance of disease- and treatment-related distress would predict the development of parental post-trauma ... | 2011 | 20591735 |
| sequential assembly of the wedge of the baseplate of phage t4 in the presence and absence of gp11 as monitored by analytical ultracentrifugation. | the baseplate wedge of bacteriophage t4 consists of seven gene products, namely, gp11, gp10, gp7, gp8, gp6, gp53, and gp25, which assemble strictly in this order with an exception that gp11 can bind to gp10 at any stage of the assembly. in this study, all the seven corresponding genes are expressed as recombinant proteins and all the possible combinations of the gene products are tested for interactions by analytical ultracentrifugation. no interactions among gene products that violate the stric ... | 2010 | 20593364 |
| surgery for renal cell carcinoma in two european urologic clinics: to compare or compete? | to evaluate and compare the incidence, tnm staging and the current strate- gy for the surgical treatment of renal cell carcinoma (rcc) in two european urologic institutions, situated in varna, bulgaria and in bari, italy. both clinics have sound experience of rcc surgery, and modern laparoscopic equipment. a retrospective chart review of all patients with rcc diagnosed and treated in the last year was conducted at the two sites. | 2010 | 20593709 |
| [changes in endothelial progenitor cells and their implications in multiple organ dysfunction syndrome caused by trauma in pigs]. | to investigate characteristics of changes in bone marrow endothelial progenitor cells (epcs) and implications on multiple organ dysfunction syndrome (mods) as a result of trauma. | 2010 | 20594467 |
| selected changes in spinal cord morphology after t4 transection and olfactory ensheathing cell transplantation. | spinal cord transection at t4 results in severe damage of the nervous tissue, with impairment of motor, sensory and autonomic functions. transplantation of olfactory ensheathing cells (oecs) has the potential to improve these functions through a number of mechanisms, which include facilitation of regeneration and neuroprotection. for cardiovascular functions, we have previously shown that oecs reduce the duration of autonomic dysreflexia, without evidence of regeneration. to further understand t ... | 2010 | 20594923 |
| examining the relationship between brominated flame retardants (bfr) exposure and changes of thyroid hormone levels around e-waste dismantling sites. | brominated flame retardants (bfrs) released from e-waste related activities may affect the health of local people. assessing the impact of e-waste exposure during recycling and dismantling activities on local people's thyroid hormone levels is an area of ongoing research. during november and december 2008, the process of e-waste recycling and dismantling was investigated, and 236 occupation-exposed people and 89 non-occupation-exposed people approximate to the e-waste recycling sites were survey ... | 2010 | 20598942 |
| discrimination of infectious bacteriophage t4 virus by propidium monoazide real-time pcr. | the advent of quantitative pcr has improved the detection of human viral pathogens in the environment. however, a serious limitation of this method may arise from the inability to discriminate between viruses that are infectious and viruses that have been inactivated and do not represent a human health hazard. to assess whether propidium monoazide (pma) pre-treatment is a good approach to inhibiting dna amplification from non-infectious viruses, bacteriophage t4 survival was measured using cell ... | 2010 | 20599560 |
| effects of experimentally induced maternal hypothyroidism and hyperthyroidism on the development of rat offspring: i. the development of the thyroid hormones-neurotransmitters and adenosinergic system interactions. | the adequate functioning of the maternal thyroid gland plays an important role to ensure that the offspring develop normally. thus, maternal hypo- and hyperthyroidism are used from the gestation day 1 to lactation day 21, in general, to recognize the alleged association of offspring abnormalities associated with the different thyroid status. in maternal rats during pregnancy and lactation, hypothyroidism in one group was performed by antithyroid drug, methimazole (mmi) that was added in drinking ... | 2010 | 20599606 |
| response of the bacteriophage t4 replisome to noncoding lesions and regression of a stalled replication fork. | dna is constantly damaged by endogenous and exogenous agents. the resulting dna lesions have the potential to halt the progression of the replisome, possibly leading to replication fork collapse. here, we examine the effect of a noncoding dna lesion in either leading strand template or lagging strand template on the bacteriophage t4 replisome. a damaged base in the lagging strand template does not affect the progression of the replication fork. instead, the stalled lagging strand polymerase recy ... | 2010 | 20600127 |
| thai acanthamoeba isolate (t4) induced apoptotic death in neuroblastoma cells via the bax-mediated pathway. | a thai acanthamoeba isolate named as recovered from a corneal scraping of a keratitis patient was genotypically determined as t4. as trophozoites were used for studying acanthamoeba-induced apoptosis in mouse neuroblastoma na cells during in vitro co-cultivation. the acanthamoeba-exposed na cells showed signs of apoptosis including cell shrinkage, nuclear condensation and dna fragmentation. the effect was confirmed by dna laddering electrophoresis. involvement of caspase enzymes and mitochondria ... | 2010 | 20601106 |
| role of pectoralis major myocutanuos flap in salvage laryngeal surgery for prophylaxis of pharyngocutaneuos fistula and reconstruction of skin defect. | aim of work: this study was carried out to minimize the incidence of pharyngocutaneous fistula (pcf) following salvage laryngeal surgery using vascularized pedicle pectoralis major myocutaneous flap (pmmc) for enhancing wound healing, rapid intake of oral feeding, reconstruction of desqauamated irradiated skin, achieving short hospital stay and protection against catastrophic blow out mortality. | 2009 | 20601968 |
| identifying and reducing error in cluster-expansion approximations of protein energies. | protein design involves searching a vast space for sequences that are compatible with a defined structure. this can pose significant computational challenges. cluster expansion is a technique that can accelerate the evaluation of protein energies by generating a simple functional relationship between sequence and energy. the method consists of several steps. first, for a given protein structure, a training set of sequences with known energies is generated. next, this training set is used to expa ... | 2010 | 20602445 |
| a survey of head and neck surgical oncologists regarding the inclusion of level iib in a neck dissection of the node negative neck. | there is controversy as to whether iib should be dissected in the node negative neck. the aim of this survey was to ascertain how often head and neck surgical oncologists performed a level iib neck dissection for node negative t2 and t4 tumours of the oral cavity, oropharynx and larynx, and to gauge how many might be willing to take part in a rct of sparing iib. a convenience sample of 110 mfu colleagues and 125 members of the entuk head and neck group were questioned. response rate for the mfu ... | 2011 | 20605290 |
| organ preservation with daily concurrent chemoradiotherapy using superselective intra-arterial infusion via a superficial temporal artery for t3 and t4 head and neck cancer. | to evaluate the therapeutic results and rate of organ preservation in patients with advanced head and neck cancer treated with superselective intra-arterial chemotherapy via a superficial temporal artery and daily concurrent radiotherapy. | 2011 | 20605340 |
| hypofractionated dose-painting intensity modulated radiation therapy with chemotherapy for nasopharyngeal carcinoma: a prospective trial. | to evaluate the feasibility of dose-painting intensity-modulated radiation therapy (dp-imrt) with a hypofractionated regimen to treat nasopharyngeal carcinoma (npc) with concomitant toxicity reduction. | 2011 | 20605352 |
| clinical implications of the tumor volume reduction rate in head-and-neck cancer during definitive intensity-modulated radiotherapy for organ preservation. | to investigate the prognostic value of the volume reduction rate (vrr) in patients with head-and-neck cancer treated with intensity-modulated radiotherapy (imrt). | 2011 | 20605362 |
| exploration of potential prodrug approach of the bis-thiazolium salts t3 and t4 for orally delivered antimalarials. | we report here the synthesis and biological evaluation of a series of 37 compounds as precursors of potent antimalarial bis-thiazolium salts (t3 and t4). these prodrugs were either thioester, thiocarbonate or thiocarbamate type and were synthesized in one step by reaction of an alkaline solution of the parent drug with the appropriate activated acyl group. structural variations affecting physicochemical properties were made in order to improve oral activity. twenty-five of them exhibited potent ... | 2010 | 20605450 |
| metastatic factors for krukenberg tumor: a clinical study on 102 cases. | to investigate factors associated with gastrointestinal (gi) carcinomas metastasizing to ovaries to form krukenberg tumor. among the 102 cases of krukenberg tumor due to gi cancers, there were 41 cases synchronously diagnosed, 43 cases with primary tumor identified first and 18 cases with ovarian tumor identified first. metastatic factors of 43 cases of metachronous krukenberg tumor were analyzed with univariate and multivariate methods. of the 43 patients, the median age at diagnosis of krukenb ... | 2010 | 20607456 |
| preoperative chest computerized tomography in patients with locally advanced mid or lower rectal cancer: its role in staging and impact on treatment strategy. | pulmonary metastasis is frequent in rectal cancer. some guidelines recommend chest computerized tomography (ct) for preoperative workup in rectal cancer patients, which have no solid evidence to support this recommendation. this study was designed to evaluate the role of chest ct on preoperative staging in rectal cancer patients and to assess the impact on treatment strategy. | 2010 | 20607759 |
| hormones of thyroid gland in sera of rats treated with different dose of concentrated potassium iodine solutions. | potassium iodine (ki) is used as a drug therapy for treating numerous diseases such as small-vessel vasculitis, erythema nodosum, vasculitis nodularis, sweet's syndrome, tuberculosis and granulomatosis, and for iodized salt. at the same time, ki can be harmful. iodine intake may increase the frequency of thyroiditis in humans, and may induce the occurrence of experimental thyroiditis (et) in animals. investigations on an experimental model for the examination of thyroiditis in wistar rats have c ... | 2010 | 20607977 |
| reversal of vecuronium with neostigmine: a comparison between male and female patients. | we investigated the differences between males and females in the reversal effect of neostigmine on neuromuscular blockade. thirty male and 30 female patients undergoing elective general anesthesia were studied. vecuronium was given in all patients anesthetized with nitrous oxide, oxygen, and sevoflurane. after the surgical procedure, when t1 (1st response in train-of-four (tof))/control returned to 0.25, neostigmine 40 microg/kg in combination with atropine 20 microg/kg was given to antagonize r ... | 2009 | 20608096 |
| three members of the iodothyronine deiodinase family, dio1, dio2 and dio3, are expressed in spatially and temporally specific patterns during metamorphosis of the flounder, paralichthys olivaceus. | flounder metamorphosis, marked by eye migration, lateralized pigmentation, and tissue differentiation in the stomach and skeletal muscle, is stimulated by thyroid hormone (th). it is known that tri-iodothyronine (t3) produced by iodothyronine deiodinase type-1 (dio1) from thyroxine (t4) enters the blood, whereas t3 produced by dio2 penetrates into the nucleus of the dio2-expressing cells, and then dio3 inactivates both t4 and t3. to better understand the distinct functions of these three deiodin ... | 2010 | 20608846 |
| urothelial carcinoma of the bladder with seminal vesicle invasion: prognostic significance. | to evaluate the prognostic impact of seminal vesicle invasion in men who underwent radical cystectomy for bladder cancer. | 2010 | 20608931 |
| endothoracic sonography improves the estimation of operability in locally advanced lung cancer. | patients with t4 non-small cell lung cancers with limited involvement of mediastinal structures can undergo resection, with acceptable long-term survival. computed tomography has not proven to be reliable in determining the operability of locally advanced lung carcinoma. this study evaluated the ability of video-assisted thoracoscopy alone and with endothoracic sonography to determine operability. | 2010 | 20609778 |
| molecular pathways of urothelial development and bladder tumorigenesis. | bladder cancer is the fifth most common human malignancy and the second most frequently diagnosed genitourinary tumor after prostate cancer. the majority of malignant tumors arising in the urinary bladder are urothelial carcinomas. clinically, superficial bladder tumors (stages ta and tis) account for 75% to 85% of neoplasms, while the remaining 15% to 25% are invasive (t1, t2-t4) or metastatic lesions at the time of initial presentation. several studies have revealed that distinct genotypic and ... | 2010 | 20610278 |
| supplemental oxygen reduces serotonin levels in plasma and platelets during colorectal surgery and reduces postoperative nausea and vomiting. | it has been shown that supplemental oxygen reduces the incidence of postoperative nausea and vomiting (ponv) in patients undergoing colon surgery. serotonin is a potent trigger of ponv. theoretically, supplemental oxygen decreases gut ischaemia during surgery and in this way minimizes the release of serotonin. we investigated the release of serotonin during and after colorectal surgery with normal and supplemental oxygen administration. | 2010 | 20613542 |
| t but not n stage predicts survival for patients with tonsillar carcinoma treated with external radiotherapy and brachytherapy. | our aim was to determine the efficacy of a therapeutic schedule including external radiation and brachytherapy in a consecutive and retrospective series of tonsillar carcinoma patients. | 2010 | 20615169 |
| acanthamoeba produces disseminated infection in locusts and traverses the locust blood-brain barrier to invade the central nervous system. | many aspects of acanthamoeba granulomatous encephalitis remain poorly understood, including host susceptibility and chronic colonization which represent important features of the spectrum of host-pathogen interactions. previous studies have suggested locusts as a tractable model in which to study acanthamoeba pathogenesis. here we determined the mode of parasite invasion of the central nervous system (cns). | 2010 | 20615207 |
| 3-monoiodothyronamine: the rationale for its action as an endogenous adrenergic-blocking neuromodulator. | the investigations reported here were designed to gain insights into the role of 3-monoiodothyronamine (t1am) in the brain, where the amine was originally identified and characterized. extensive deiodinase studies indicated that t1am was derived from the t4 metabolite, reverse triiodothyronine (revt3), while functional studies provided well-confirmed evidence that t1am has strong adrenergic-blocking effects. because a state of adrenergic overactivity prevails when triiodothyronine (t3) concentra ... | 2010 | 20615397 |
| development of morulae from the oocytes of cultured sheep preantral follicles. | sheep preantral follicles (pfs) measuring 250-400 microm in diameter were cultured for six days in serum-free media supplemented differently with growth factors and hormones. subsequently, oocytes from the cultured follicles were subjected to an additional 24 h of in vitro maturation (ivm) followed by in vitro fertilization (ivf) and embryo culture for 6 days. five different experiments were conducted. in the first experiment individual concentrations of insulin-transferrin-selenite (its), insul ... | 2010 | 20615540 |
| systematic review: should routine resection of the extra-hepatic bile duct be performed in gallbladder cancer? | complete surgical resection is associated with improved outcomes in gallbladder cancer. whether the extra-hepatic bile duct (ehbd) should be routinely excised for gallbladder cancer is unclear. | 2010 | 20616410 |
| molecular regulation of thyroid gland function. | for de-novo thyroid hormone synthesis ex vivo, thyroid follicular cells require a serum-free medium supplying nutrients, iodide, thyroid-stimulating hormone and insulin-like growth factor i (igf-i) (or insulin). under these conditions, t3 and t4 are secreted but so are other factors such as growth factors, plasminogen activators, their inhibitors known as serpins, and so on. what is the function of these factors? do thyroid cells respond to them or are these paracrine/endocrine factors? the purp ... | 2010 | 20616713 |
| usefulness of endoscopic ultrasonography in preoperative gastric cancer staging: diagnostic yield and therapeutic impact. | to evaluate the diagnostic yield of endoscopic ultrasonography in loco-regional staging of gastric cancer in our medium and to determine the impact of this technique on later therapeutic management. | 2010 | 20617861 |
| can increasing the dose of radiation by hdr brachytherapy boost following pre operative chemoradiotherapy for advanced rectal cancer improve surgical outcomes? | preoperative radiotherapy has been shown to improve local control in advanced rectal carcinoma compared with surgery alone. several large randomized trials have confirmed that chemoradiotherapy (crt) is better than radiotherapy alone. this pilot study was designed to increase the radiation dose using high-dose rate (hdr) brachytherapy boost following preoperative crt to evaluate whether this strategy improves the outcome of surgery without increase in toxicity. | 2010 | 20618365 |
| neurochemical measures co-vary with personality traits: forensic psychiatric findings replicated in a general population sample. | neurobiological markers in cerebrospinal fluid (csf) and in serum, previously found to co-vary with destructive personality traits in violent offenders, were explored in a general population sample of 21 patients undergoing knee surgery. results on the karolinska scales of personality (ksp) and the temperament and character inventory (tci) were compared with csf/serum albumin ratios and serum concentrations of beta-trace protein (betatp) (as markers for blood-brain barrier (bbb) permeability), t ... | 2010 | 20619466 |
| high-dose split-course radiation therapy for anal cancer: outcome analysis regarding the boost strategy (cors-03 study). | to retrospectively assess the clinical outcome in anal cancer patients treated with split-course radiation therapy and boosted through external-beam radiation therapy (ebrt) or brachytherapy (bct). | 2010 | 20619552 |
| stage iv prostate cancer: survival differences in clinical t4, nodal and metastatic disease. | in the prostate specific antigen era most prostate cancer presents at an early stage. however, a significant number of patients have advanced disease, including those with stage iv disease. assignment to stage iv prostate cancer may occur by different modes, namely as t4n0m0 vs n1 vs m1 disease. we hypothesize that patients with clinical t4 disease have better outcomes than those with n1 or m1 disease. | 2010 | 20620410 |
| survival in oral cavity minor salivary gland carcinoma. | to describe the epidemiology and comparative survival for minor salivary gland cancer of the oral cavity. | 2010 | 20620630 |
| does surgery have a role in t4n0 and t4n1 lung cancer? | a best evidence topic in thoracic surgery was written according to a structured protocol. the question addressed whether [surgery] has a role in [treatment of t4n0 and t4n1 lung cancer]. altogether more than 151 papers were found using the reported search, of which 15 represented the best evidence to answer the clinical question. the authors, journal, date and country of publication, patient group studied, study type, relevant outcomes and results of these papers are tabulated. we conclude that ... | 2010 | 20621998 |
| hypothyroid phenotype of the tpst2 mutant mouse is dependent upon genetic background. | dw/j-grt is a congenital hypothyroid mouse model that is characterized by growth retardation, significantly lowered t3 and t4 levels, and severe thyroid hypoplasia related to tsh hyporesponsiveness. previously, we identified the point mutation of the tpst2 gene in dw/j-grt mice that causes a decrease in the enzymatic activity, and demonstrated that the tpst2 transgene rescues the mutant phenotypes both in vitro and in vivo. the severity of hypothyroidism is highly variable indicating the influen ... | 2010 | 20622471 |
| thyroid hormones, mitochondrial bioenergetics and lipid handling. | the article is principally intended to describe the recent evolutions in the field of research concerned with the metabolic actions of thyroid hormones and those of some of their metabolites or derivatives. mitochondria, as a result of their functions, represent the principal objective of scientists investigating the mechanisms underlying the effects of thyroid hormones or their metabolites/derivatives. | 2010 | 20625286 |
| [comparing extended vertical partial laryngectomy and cricohyoidoepiglottopexy in the treatment of laryngeal carcinoma]. | to compare the results of extended vertical partial laryngectomy (similar to modified supracricoid partial laryngectomy with cricohyoidoepiglottopexy) and cricohyoidoepiglottopexy in the treatment of laryngeal carcinoma. | 2010 | 20627050 |
| hydrolytic cleavage of double-strand dna by the water-soluble dicobalt(iii) complexes of 1,4,7-triazacyclononane-n-acetate. | three water-soluble dicobalt(iii) complexes, [co(2)l(2)(micro-oh)(2)](clo(4))(2).5h(2)o (1), [co(2)l(2)(micro-oh)(2)](clo(4))(2).ch(3)oh.h(2)o(2); [co(2)l(2)(micro-oh)(2)](clo(4))(2).4h(2)o(3) (l=1,4,7-triazacyclononane-n-acetate monoanion), were prepared to serve as nuclease mimics. the complexes were characterized by x-ray, ir and uv-vis spectroscopy as well as esi-ms. three complexes exhibit similar structures, just with different solvent molecules. the electrospray mass spectrum of 1 in solu ... | 2010 | 20627402 |
| binding to complement factors and activation of the alternative pathway by acanthamoeba. | acanthamoeba can cause severe ocular and cerebral diseases in healthy and immunocompromised individuals, respectively. activation of complement appears to play an important role in host defence against infection. the exact mechanism, however, is still unclear. the aim of the present study was to investigate the effect of normal human serum (nhs) and normal mouse serum (nms) on acanthamoeba trophozoites, the binding of different complement factors to acanthamoeba and the activation of the complem ... | 2011 | 20627448 |
| mutational clusters generated by non-processive polymerases: a case study using dna polymerase betain vitro. | available dna mutational spectra reveal that the number of mutants with multiple mutations ("multiples") is usually greater than expected from a random distribution of mutations among mutants. these overloads imply the occurrence of non-random clusters of mutations, probably generated during episodes of low-fidelity dna synthesis. excess multiples have been reported not only for viruses, bacteria, and eukaryotic cells but also for the dna polymerases of phages t4 and rb69 in vitro. in the simple ... | 2010 | 20627824 |
| traumatic pediatric pneumorachis: case report and review of the literature. | case report. | 2010 | 20628329 |
| subclinical hypothyroidism in children: normal variation or sign of a failing thyroid gland? | subclinical hypothyroidism (sch), defined by a normal total or free t4 level and a mildly elevated tsh (typically 5-10 mu/l), is common in children, but there is currently no consensus on management. several recent pediatric studies indicate that progression of sch to overt hypothyroidism (oh) is uncommon and that over a period of several years, elevated tsh usually either normalizes or persists but does not increase. the etiology appears to be multifactorial, with some cases representing minor ... | 2010 | 20628588 |
| chromosome 9p deletions identify an aggressive phenotype of clear cell renal cell carcinoma. | the authors investigated whether deletion of chromosome 9p in clear cell renal cell carcinoma (ccrcc) predicted worse disease-specific survival (dss) and recurrence-free survival (rfs) and whether it was associated with more aggressive behavior in small renal masses. | 2010 | 20629029 |
| hypothyroidism during antithyroid drug treatment with methimazole is a favorable prognostic indicator in patients with graves' disease. | a major problem with antithyroid drug (atd) therapy in graves' disease is the high relapse rate. therefore, clinicians have sought prognostic indicators of permanent remission. suppression of serum thyrotropin (tsh) when atd therapy is stopped carries a poor prognosis, but little is known regarding the significance of elevated serum tsh concentrations in the course of atd therapy. the objective of this study was to determine if elevated serum tsh concentrations during methimazole (mmi) therapy i ... | 2010 | 20629556 |
| free triiodothyronine is associated with smoking habit, independently of obesity, body fat distribution, insulin, and metabolic parameters. | the aim of this study was to examine the relationship between thyroid hormones and smoking and several other parameters like age, gender, insulin, and anthropometric and metabolic parameters in subjects with a wide range of body mass index (bmi). | 2010 | 20634638 |
| an evaluation of fracture stabilization comparing kyphoplasty and titanium mesh repair techniques for vertebral compression fractures: is bone cement necessary? | in vitro biomechanical investigation using human cadaveric vertebral bodies. | 2010 | 20634659 |
| upregulation of tlr2/4 expression in mononuclear cells in postoperative systemic inflammatory response syndrome after liver transplantation. | to explore the relationship between toll-like rpheral blood mononuclear cells (pbmc) and systemic inflammatory response syndrome (sirs) in postoperative patients of liver transplantation (lt). | 2010 | 20634913 |
| severe congestive heart failure patient on amiodarone presenting with myxedemic coma: a case report. | this is a case report of myxedema coma secondary to amiodarone-induced hypothyroidism in a patient with severe congestive heart failure (chf). to our knowledge and after reviewing the literature there is one case report of myxedema coma during long term amiodarone therapy. myxedema coma is a life threatening condition that carries a mortality reaching as high as 20% with treatment. the condition is treated with intravenous thyroxine (t4) or intravenous tri-iodo-thyronine (t3). patients with chf ... | 2009 | 20635749 |
| adhesion pattern and growth of primary human osteoblastic cells on five commercially available titanium surfaces. | the aim of this study is to analyze the morphology and proliferation of human osteoblastic cells in vitro on five commercially available titanium surfaces. | 2010 | 20636730 |
| clinical study on the effects of a cosmetic product on dermal extracellular matrix components using a high-resolution multiphoton tomograph. | the aim of this study was to demonstrate the effects of selected plant extracts in a cosmetic cream on the dermal network components after a 3-month treatment using an in vivo multiphoton tomographic device. | 2010 | 20636999 |
| the number of lymph nodes examined debate in colon cancer: how much is enough? | much debate exists over the significance of the number of lymph nodes (ln) examined after colon resection. | 2010 | 20638686 |