| the interaction between growth hormone and the thyroid axis in hypopituitary patients. | alterations in the hypothalamo-pituitary-thyroid axis have been reported following growth hormone (gh) administration in both adults and children with and without growth hormone deficiency. reductions in serum free thyroxine (t4), increased tri-iodothyronine (t3) with or without a reduction in serum thyroid-stimulating hormone secretion have been reported following gh replacement, but there are wide inconsistencies in the literature about these perturbations. the clinical significance of these c ... | 2011 | 20455887 |
| paracrine signaling by glial cell-derived triiodothyronine activates neuronal gene expression in the rodent brain and human cells. | hypothyroidism in humans is characterized by severe neurological consequences that are often irreversible, highlighting the critical role of thyroid hormone (th) in the brain. despite this, not much is known about the signaling pathways that control th action in the brain. what is known is that the prohormone thyroxine (t4) is converted to the active hormone triiodothyronine (t3) by type 2 deiodinase (d2) and that this occurs in astrocytes, while th receptors and type 3 deiodinase (d3), which in ... | 2010 | 20458138 |
| [classification and characters of physical parameters of lifting-thrusting and twirling manipulations of acupuncture]. | by using "acupuncture manipulation information analyzing system", the traditional reinforcing and reducing manipulations of acupuncture described in classical chinese medical books were imitated and their parameters analyzed. it was found that in the oscillogram, the differences between the reinforcing and reducing manipulations (rapid-slow reinforcing-reducing skill, lifting-thrusting reinforcing-reducing skill) are the bigger duration of descending branch (t1) and smaller duration of ascending ... | 2010 | 20458910 |
| incorporation of gemcitabine and cytarabine into dna by dna polymerase beta and ligase iii/xrcc1. | 1-beta-d-arabinofuranosylcytosine (cytarabine, arac) and 2',2'-difluoro-2'-deoxycytidine (gemcitabine, dfdc), are effective cancer chemotherapeutic agents due to their ability to become incorporated into dna and then subsequently inhibit dna synthesis by replicative dna polymerases. however, the impact of these 3'-modified nucleotides on the activity of specialized dna polymerases has not been investigated. the role of polymerase beta and base excision repair may be of particular importance due ... | 2010 | 20459144 |
| partial pressure of carbon dioxide in the venous blood of young birds as a predictor of ascites susceptibility in broiler chickens. | in order to investigate the relationship between carbon dioxide tensions in the venous blood of young chickens and ascites susceptibility, one hundred day-old chickens from two pure broiler breeder lines differing in susceptibility to ascites syndrome were obtained and reared at low environmental temperature. weekly, blood samples were taken for the determination of blood gas parameters and plasma thyroid hormone levels. dead birds were examined for lesions of ascites daily and all survived bird ... | 2010 | 20460221 |
| detrusor activity is impaired during thoracic epidural analgesia after open renal surgery. | there are no data on lower urinary tract function during postoperative thoracic epidural analgesia (tea). because selected segmental blockade can be achieved with epidural analgesia, we hypothesized that lower urinary tract function remains unchanged during tea within segments t4-t11 after open renal surgery. | 2010 | 20461004 |
| cervical epidural injection complicated by syrinx formation: a case report. | case report and review of literature. | 2010 | 20461029 |
| xanthohumol, a prenylated chalcone from hops, modulates hepatic expression of genes involved in thyroid hormone distribution and metabolism. | in the present study, we analyzed the influence of xanthohumol (xn) on thyroid hormone (th) distribution and metabolism in rats. a potent and selective competition of xn for thyroxine (t4) binding to transthyretin (ic(50)=1 microm at 1.7 nm [(125)i]t4) was found in human and rat sera in vitro. female rats treated orally with xn showed increased hepatic expression of t4-binding globulin and decreased transthyretin and albumin. thyrotropin levels and hepatic type 1 deiodinase activity were moderat ... | 2010 | 20461738 |
| the expression of claudin-1, claudin-2, claudin-3, and claudin-4 in gastric cancer tissue. | the claudins (cldns) are a family of functional tight junction proteins, and are involved with the epithelial-to-mesenchymal transition (emt). the claudin proteins have a significant influence on the biological behavior of tumor progression in several types of cancers. in this study, we aimed to evaluate the expression pattern of claudin-1, claudin-2, claudin-3, and claudin-4 in gastric cancer tissue. | 2011 | 20462599 |
| gingival carcinoma: retrospective analysis of 72 patients and indications for elective neck dissection. | gingival squamous cell carcinoma (scc) is relatively uncommon, and little is known about its metastatic pattern. we retrospectively reviewed 864 consecutive patients with oral scc who were seen at the university of maryland department of oral and maxillofacial surgery (1991-2005), and identified 111 cases of gingival scc. inclusion criteria were fulfilled in 72 patients (mean duration of follow up 49 (1-153) months). mean (range) age was 72 (45-93) years; 41 patients were women and 31 men. distr ... | 2011 | 20462676 |
| [feasibility to use of recombinant domains of immunoglobulin-like protein liga as a promising marker for serological testing of patients with leptospirosis]. | to clone the dna fragment encoding conservative domain of liga protein of leptospira interrogans into escherichia coli and to investigate antigenic properties of constructed chimeric protein. | 2010 | 20465007 |
| vaginal obliteration in a woman with a history of cutaneous t-cell lymphoma: the results of combined chemotherapy-induced gonadal toxicity and lymphoma relapse. | although ovarian failure commonly occurs following chemotherapy, the relation between menopause or related sexual activity in this failure is often overlooked. we report a case that emphasizes a clinically rare complication, the complete obliteration of the vagina. | 2010 | 20466296 |
| oncofetal fibronectin mrna is highly abundant in the blood of patients with papillary thyroid carcinoma and correlates with high-serum thyroid-stimulating hormone levels. | papillary thyroid carcinoma (ptc) cells express oncofetal fibronectin (onffn) mrna, which may be useful to detect circulating tumor cells. the objective of this study was to determine the fraction of ptc patients having onffn mrna in their peripheral blood and to determine if onffn mrna levels are correlated with the status of the disease or with thyroid-stimulating hormone (tsh) serum concentrations. | 2010 | 20470202 |
| oxaliplatin plus dual inhibition of thymidilate synthase during preoperative pelvic radiotherapy for locally advanced rectal carcinoma: long-term outcome. | to assess the safety and efficacy of oxaliplatin (oxa) plus dual inhibition of thymidilate synthase during preoperative pelvic radiotherapy (rt) in patients with poor prognosis for rectal carcinoma. | 2011 | 20472346 |
| mitomycin-c- or cisplatin-based chemoradiotherapy for anal canal carcinoma: long-term results. | to evaluate the long-term efficacy of concurrent radiotherapy with mitomycin-c (mmc)-based or cisplatin (cp)-based combinations in a cohort of patients with locally advanced anal canal carcinoma. | 2011 | 20472349 |
| quantification of uv-induced cyclobutane pyrimidine dimers using an oligonucleotide chip assay. | a lesion-specific enzyme-induced dna strand break assay was developed for an oligonucleotide chip for the determination of uvb-induced cyclobutane pyrimidine dimers (cpds). a 20-mer of fluorophore-labeled and biotinylated oligonucleotide was immobilized on the chip. cpds in dna on the chip were formed by uvb irradiation (312 nm). t4 endonuclease v (t4n5) was used to excise the cpd site as t4n5 sensitively and specifically detects cpds. the fluorophore-labeled dna fragments were detected by a las ... | 2010 | 20473657 |
| role of fine needle aspiration cytology in thyroiditis. | fine needle aspiration (fna) of thyroid is a cost-effective, simple, diagnostic tool in the initial screening of patients with thyroid lesions. its role in a minimally enlarged thyroid in a symptomatic patient suspected of thyroid dysfunction is now well known. it plays an important role in the medical management of all nonpalpable/minimally enlarged thyroid (goiter) in patients suspect for thyroid pathology and/or in combination with thyroid-stimulating hormone, t3 and t4 levels by diagnosing e ... | 2007 | 20476954 |
| management of gallbladder cancer. | resection is a means of improving survival in patients with gallbladder cancer. a more aggressive surgical approach, including resection of the gallbladder, liver, and regional lymph nodes, is advisable for patients with t1b to t4 tumors. aggressive resection is necessary because a patient's gallbladder cancer stage determines the outcome, not the surgery itself. therefore, major resections should be offered to appropriately selected patients. patients with advanced tumors or metastatic disease ... | 2010 | 20478489 |
| pattern and amount of change after orthodontic correction of upper front teeth 7 years postretention. | to investigate the amount and pattern of changes of maxillary front teeth 7 years postretention, which previously were retained with a bonded retainer. | 2010 | 20482345 |
| early headgear effect on the eruption pattern of maxillary second molars. | to test the hypothesis that the use of a combination headgear (hg) during the first phase of orthodontic treatment has no effect on the eruption pattern of the maxillary second permanent molars. | 2010 | 20482348 |
| age and the thyrotropin response to hypothyroxinemia. | some studies suggest altered pituitary functioning and tsh production with aging. | 2010 | 20484476 |
| sorafenib-induced hypothyroidism is associated with increased type 3 deiodination. | therapy with tyrosine kinase inhibitors is associated with thyroid dysfunction. decreased serum thyroid hormone levels during tyrosine kinase inhibitors are also observed in athyreotic patients with thyroid carcinoma. we therefore hypothesized that tyrosine kinase inhibitors may influence thyroid hormone metabolism. | 2010 | 20484486 |
| supplementation of farta sheep fed hay with graded levels of concentrate mix consisting of noug seed meal and rice bran. | the study was carried out at woreta, ethiopia, to determine feed intake, digestibility, body weight (bw) change, and profitability of farta sheep fed pasture hay alone or supplemented with graded levels of concentrate mix (cm) consisting of noug seed meal (nsm) and rice bran in 2:1 ratio. twenty yearling intact male farta sheep with bw of 16.9 +/- 1.68 kg (mean +/- sd) were used in randomized complete block design arranged into five blocks of four animals. the dietary treatments consisting of so ... | 2010 | 20490664 |
| identification of a new motif in family b dna polymerases by mutational analyses of the bacteriophage t4 dna polymerase. | structure-based protein sequence alignments of family b dna polymerases revealed a conserved motif that is formed from interacting residues between loops from the n-terminal and palm domains and between the n-terminal loop and a conserved proline residue. the importance of the motif for function of the bacteriophage t4 dna polymerase was revealed by suppressor analysis. t4 dna polymerases that form weak replicating complexes cannot replicate dna when the dgtp pool is reduced. the conditional let ... | 2010 | 20493878 |
| the folding cooperativity of a protein is controlled by its chain topology. | the three-dimensional structures of proteins often show a modular architecture comprised of discrete structural regions or domains. cooperative communication between these regions is important for catalysis, regulation and efficient folding; lack of coupling has been implicated in the formation of fibrils and other misfolding pathologies. how different structural regions of a protein communicate and contribute to a protein's overall energetics and folding, however, is still poorly understood. he ... | 2010 | 20495548 |
| reliability of vertebral fracture assessment using multidetector ct lateral scout views: the framingham osteoporosis study. | two radiologists evaluated images of the spine from computed tomography (ct) scans on two occasions to diagnose vertebral fracture in 100 individuals. agreement was fair to good for mild fractures, and agreement was good to excellent for more severe fractures. ct scout views are useful to assess vertebral fracture. | 2011 | 20495902 |
| salvage surgery for local recurrence after chemoradiotherapy or radiotherapy in hypopharyngeal cancer patients. | this retrospective study aimed to assess the role of salvage surgery for local recurrence in hypopharyngeal cancer (hpc) patients who had received radiotherapy (rt) or concomitant chemoradiotherapy (crt) as an initial treatment. the local recurrence rate, salvage rate after local recurrence and overall survival rate were investigated in 104 hpc patients who received treatment between 1991 and 2005. local recurrence in the primary site was observed in 41 patients (rate, 39.4%) of whom only 12 cou ... | 2010 | 20495926 |
| a combined rt-pcr and dot-blot hybridization method reveals the coexistence of sjnnv and rgnnv betanodavirus genotypes in wild meagre (argyrosomus regius). | to detect the possible coexistence of striped jack nervous necrosis virus (sjnnv) and red-spotted grouper nervous necrosis virus (rgnnv) genotypes in a single fish, a methodology based on the combination of pcr amplification and blot hybridization has been developed and applied in this study. | 2010 | 20497277 |
| functional analysis of the highly antigenic outer capsid protein, hoc, a virus decoration protein from t4-like bacteriophages. | bacteriophage t4 is decorated with 155 copies of the highly antigenic outer capsid protein, hoc. the hoc molecule (40 kda) is present at the centre of each hexameric capsomer and provides a good platform for surface display of pathogen antigens. biochemical and modelling studies show that hoc consists of a string of four domains, three immunoglobulin (ig)-like and one non-ig domain at the c-terminus. biochemical data suggest that the hoc protein has two functional modules, a capsid binding modul ... | 2010 | 20497329 |
| better late than early: delayed translation of intron-encoded endonuclease i-tevi is required for efficient splicing of its host group i intron. | the td group i intron interrupting the thymidylate synthase (ts) gene of phage t4 is a mobile intron that encodes the homing endonuclease i-tevi. efficient rna splicing of the intron is required to restore function of the ts gene, while expression of i-tevi from within the intron is required to initiate intron mobility. three distinct layers of regulation temporally limit i-tevi expression to late in the t4 infective cycle, yet the biological rationale for stringent regulation has not been teste ... | 2010 | 20497330 |
| cord blood thyroid-stimulating hormone and free t4 levels in turkish neonates: is iodine deficiency still a continuing problem? | the objectives of this study were to determine the cord blood thyroid-stimulating hormone (tsh) and free t(4) (ft(4) ) levels in turkish neonates and to determine whether these variables reveal iodine deficiency. | 2010 | 20497362 |
| paclitaxel and carboplatin as neoadjuvant chemotherapy in patients with locally advanced breast cancer: a phase ii trial of the hellenic cooperative oncology group. | this phase ii study sought to evaluate the efficacy of the paclitaxel-carboplatin combination as neoadjuvant chemotherapy in patients with locally advanced breast cancer (labc). | 2010 | 20497922 |
| [bacteriophage t4: molecular aspects of bacterial cell infection and the role of capsid proteins]. | bacteriophage t4 of the myoviridae family is ubiquitous in the environment and living organisms. in microbiology it has become a universal research model for the mechanisms of many biological processes, including bacteriophage infection. t4 phage is a tailed phage, the most frequent bacteriophage group. it is made up of a head, a contractile tail, and dsdna. its tail is a complex structure composed of a collar and its whiskers, a tail tube, a base plate, short fibers, and tail fibers. all these ... | 2010 | 20498502 |
| preoperative local staging of esophageal carcinoma using dual-phase contrast-enhanced imaging with multi-detector row computed tomography: value of the arterial phase images. | to evaluate whether the accuracy of local extension (t-staging) of esophageal carcinoma could be improved with addition of arterial phase images by use of multi-detector row computed tomography. | 2010 | 20498545 |
| comprehensive effects of supplemented essential amino acids in patients with severe copd and sarcopenia. | aim of the study was to investigate whether or not oral supplementation of essential amino acids (eaas) may improve body composition, muscle metabolism, physical activity, cognitive function, and health status in a population of subjects with severe chronic obstructive pulmonary disease (copd) and sarcopenia. | 2010 | 20499791 |
| haemostasis in head and neck surgical procedures: valsalva manoeuvre versus trendelenburg tilt. | the aim of the study was to identify whether trendelenburg position helps detect any further bleeding points following valsalva manoeuvre in order to achieve adequate haemostasis in head and neck surgery. | 2010 | 20501015 |
| a randomized controlled trial of the effect of thyroxine replacement on cognitive function in community-living elderly subjects with subclinical hypothyroidism: the birmingham elderly thyroid study. | subclinical hypothyroidism (sch) and cognitive dysfunction are both common in the elderly and have been linked. it is important to determine whether t4 replacement therapy in sch confers cognitive benefit. | 2010 | 20501682 |
| intense therapy in patients with locally advanced esophageal cancer beyond hope for surgical cure: a prospective, multicenter phase ii trial of the swiss group for clinical cancer research (sakk 76/02). | there is no standard treatment for patients with locally advanced esophageal carcinoma without systemic metastasis in whom surgery is no longer considered a reasonable option. | 2010 | 20502056 |
| effect of sex, age, and anthropometric parameters on the size and shape of vertebrae in densitometric morphometry: results of the epolos study. | morphometric densitometry (morphometric x-ray absorptiometry - mxa) allows to identify vertebral fractures, based on the objective measurement of vertebral dimensions. | 2010 | 20502404 |
| [the "aktion t4" : in remembrance of victims of the healing and nursing institution in günzburg.] | objective: the aim of this article was to achieve a commemoration of patients of the healing and nursing institute in günzburg who were victims of "aktion t4". methods: on the basis of pre-defined criteria several individual patient documents were selected for this study and analyzed historically. most items of information concerning patient histories and diagnoses were obtained from the stock r 179 of the branch office of the federal archives in berlin lichterfelde. further supplementary inform ... | 2010 | 20502857 |
| comparison of testis structure, function and thyroid hormone levels in control c57bl/6 mice and anti-mullerian hormone over expressing mice. | anti-mullerian hormone (amh) is considered as a negative regulator of postnatal leydig cell (lc) differentiation, because amh over expressing mice (mt-hamh mice) testes are deficient in lc. therefore, in the present study mt-hamh mice was used as a model to examine the process of postnatal lc differentiation. testis structure-function studies were performed in age-matching mt-hamh and c57bl/6 (controls) mice; testicular components were quantified and circulating testosterone and thyroid hormone ... | 2010 | 20503178 |
| inflammatory breast cancer in italy: epidemiological and clinical aspects. | breast cancer represents the most common cancer among women in italy. in the last decade, an increase in incidence and a decrease in mortality from breast cancer have been observed in italy. these findings may be explained at least in part by the implementation of organized screening programs (smps). the screening programs are not diffused homogeneously throughout italy, where approximately 60% of the population in covered, which explains in part the different outcomes observed across italy. on ... | 2010 | 20503402 |
| thyroid dysfunction in pregnancy: definition of tsh cut-off should precede the decision of screening in low-risk pregnant women. | to evaluate the frequency of elevated tsh in pregnant women of low risk for thyroid dysfunction. | 2011 | 20504103 |
| inhibitory effects of diacylglyceride phospholipids on dna polymerase and topoisomerase activities, and human cancer cell growth. | this paper describes the inhibitory activities of diacylglyceride phospholipids, such as phosphatidylcholine (lecithin), phosphatidylethanolamine (cephalin), phosphatidylserine, phosphatidylglycerol, bisphosphatidylglycerol (cardiolipin), phosphatidylinositol, and phosphatidic acid (phosphatidate) (compounds 1 - 7, respectively) against dna polymerase (pol), dna topoisomerase (topo), and human cancer cell growth. among the compounds tested, compounds 3 - 7 were revealed to be potent inhibitors o ... | 2010 | 20507270 |
| molecular cloning of brassica rapa nitrilases and their expression during clubroot development. | summary three isoforms of nitrilase were cloned from turnip, brassica rapa l., and their expression during clubroot development caused by plasmodiophora brassicae was investigated. the isoforms were designated brnit-t1, brnit-t2 and brnit-t4 based on homology to known nitrilases. brnit-t1 and brnit-t2 have 80% homology to three nitrilases from arabidopsis thaliana (atnit1, atnit2 and atnit3). brnit-t4 showed 90% homology to atnit4. to confirm their enzyme activity, the recombinant proteins were ... | 2007 | 20507526 |
| morphometric analysis of the thoracic pedicle: an anatomico-radiological study. | knowledge of the morphometric anatomy of the pedicles in thoracic spine is essential for the surgeon attempting thoracic pedicle screw placement. | 2010 | 20508345 |
| predictive value of 18f-fluorodeoxyglucose uptake by positron emission tomography for non-small cell lung cancer patients treated with radical radiotherapy. | the purpose of this study is to assess predictive value of the positron emission tomography (pet) with 18f-fluoro-deoxyglucose (fdg) for recurrence and survival after radiotherapy (rt) for non-small cell lung cancer (nsclc). one hundred forty-nine patients underwent pretreatment pet (n = 67) or pet/computed tomography (ct) (n = 82) and definitive rt for nsclc. we evaluated the relationship between the maximum-pixel standardized uptake value (suv(max)) and clinical tumor features. univariate cox ... | 2010 | 20508373 |
| assessment of iodine and non-iodine deficiency hypothyroidism in women of reproductive ages in the sub-himalayan plains of west bengal. | indian women of reproductive age groups commonly suffer from hypothyroidism which may be due to iodine or non iodine deficiency causes. this study was undertaken with a view to ascertain the leading cause of hypothyroidism in women of reproductive age group residing in the sub-himalayan plain areas of darjeeling district of west bengal. serum tsh, t4, t3 and urinary iodine excretion (uie) levels were measured in 101 non pregnant women. our results reveal that among 37.62% (n=38) of bio-chemicall ... | 2009 | 20509329 |
| hydroxylated polybrominated diphenyl ethers and bisphenol a in pregnant women and their matching fetuses: placental transfer and potential risks. | hydroxylated polybrominated diphenyl ethers (oh-pbdes) are suspected endocrine disruptors, which can pass through the mammalian placenta and accumulate in the human maternal-fetal-placental unit. however, little is known about mechanisms of placental transfer and the associated risk(s). ten oh-pbde congeners, bisphenol a (bpa), total 17beta-estradiol (e2), and total thyroxine (t4) were quantified in blood serum from 26 pregnant women and 28 matching fetuses, including three pairs of twins from s ... | 2010 | 20509646 |
| ft4 immunoassays may display a pattern during pregnancy similar to the equilibrium dialysis id-lc/tandem ms candidate reference measurement procedure in spite of susceptibility towards binding protein alterations. | serum free thyroxine (ft4) testing in pregnancy is known to be challenging for immunoassays (ias). we verified the reliability of ft4 results by 3 commercial ias throughout pregnancy, by comparison of the pattern to that obtained with an equilibrium dialysis isotope dilution-mass spectrometry (ed id-ms) candidate reference measurement procedure. | 2010 | 20510682 |
| [homocysteinemia in polycystic ovary syndrome women]. | to compare serum homocysteine levels in polycystic ovary syndrome (pcos) and non-pcos women and correlate them with clinical, hormonal and metabolic parameters. | 2010 | 20512259 |
| frequency of subclinical thyroid dysfunction and risk factors for cardiovascular disease among women at a workplace. | subclinical thyroid dysfunction is very common in clinical practice and there is some evidence that it may be associated with cardiovascular disease. the aim here was to evaluate the frequencies of subclinical thyroid disease and risk factors for cardiovascular disease among women at a workplace, and to evaluate the association between subclinical thyroid disease and cardiovascular risk factors among them. | 2010 | 20512276 |
| highly sensitive detection of dna phosphorylation by counting single nanoparticles. | dna phosphorylation is a vital process in the repair, replication, and recombination of nucleic acids. traditionally, it is assayed by denaturing gel electrophoresis and autoradiography, which are tedious and not sensitive. we report on the development of a sensitive, simple, and economical method for dna phosphorylation detection and t4 polynucleotide kinase (t4 pnk) activity assay based on marking dna phosphorylation/biotinylation events by the attachment of fluorescent nanoparticles. enzyme a ... | 2010 | 20512316 |
| squamous cell carcinoma of the temporal bone. | to study the survival outcomes of patients with squamous cell carcinoma (scc) of the temporal bone. a secondary purpose was to evaluate the university of pittsburgh staging system as a predictor of survival. | 2010 | 20513031 |
| integrated positron emission tomography-computed tomography does not accurately stage intrathoracic disease of patients undergoing trimodality therapy for malignant pleural mesothelioma. | the results of trimodality therapy for malignant pleural mesothelioma (mpm) are related to stage. staging can be carried out by computed tomography (ct), magnetic resonance imaging and fluorodeoxyglucose positron emission tomography (fdg-pet), but all modalities suffer from limitations. we investigated whether integrated pet-ct improved the intrathoracic staging of patients undergoing trimodality therapy for mpm. | 2010 | 20514576 |
| effect of intrapleural povidone-iodine lavage on thyroid hormones in thoracic surgery. | povidone-iodine (pi) is an effective disinfectant used in many surgical operations. it is known that pi is absorbed by the skin after application. absorption is even greater in infants, as their skin is thinner and more permeable. iodine absorption in the orbita, neck and during abdominal surgery has been previously investigated, but such a study has not been performed for the pleura, which has a greater area and capacity for absorption. in this study, we investigated the effect of intraoperativ ... | 2010 | 20514578 |
| menstrual irregularity: a possible clinical marker of metabolic dysfunction in women with class iii obesity. | to evaluate whether menstrual irregularity in morbidly obese women is indicative of metabolic dysfunction. | 2010 | 20515256 |
| phase ii study of pre-operative radiotherapy with capecitabine and oxaliplatin for rectal cancer and carcinoembryonic antigen as a predictor of pathological tumour response. | this study investigated the efficacy and tolerability of pre-operative radiotherapy with concurrent capecitabine and oxaliplatin in patients with rectal cancer. forty-seven patients with rectal adenocarcinoma (stages t3 - t4; node-positive) were enrolled and received radiotherapy (46 gy in 23 fractions) in combination with capecitabine (1000 mg/m(2) twice daily on days 1 - 14 and 22 - 35) and oxaliplatin (130 mg/m(2) on days 1 and 22) (xelox regimen). the main endpoints were safety and efficacy, ... | 2010 | 20515578 |
| subclinical thyroid disease in elderly subjects. | subclinical thyroid disease (std) is defined as circulating concentrations of free t4 and free t3 within their respective reference ranges in the presence of abnormal circulating concentrations of tsh. scd is being diagnosed more frequently in clinical practice and is reported to be more prevalent in elderly as compared to young or adult subjects. the clinical impact of subclinical thyroid dysfunction is still a matter of debate, although it has been associated with various negative clinical out ... | 2010 | 20518189 |
| assessment of low-density lipoprotein oxidation, paraoxonase activity, and arterial distensibility in epileptic children who were treated with anti-epileptic drugs. | studies show that anti-epileptic drugs increase oxidative stress. thus, low-density lipoprotein oxidation increases and atherogenesis is induced. paraoxonase-associated high-density lipoprotein protects low-density lipoprotein and high-density lipoprotein oxidation. the effects of anti-epileptic drugs on paraoxonase activity has not been investigated yet. the aim of this study is to investigate the effect of anti-epileptic drugs on paraoxonase activity, lipid profiles, folat, vitamin b12, homocy ... | 2010 | 20519057 |
| a randomized simultaneous comparison of acceleromyography with a peripheral nerve stimulator for assessing reversal of rocuronium-induced neuromuscular blockade with sugammadex. | we investigated the relationship between acceleromyography and a peripheral nerve stimulator for measuring reversal in patients administered sugammadex following rocuronium. | 2010 | 20523215 |
| effect of difluoromethylornithine on thyroid function in rats. | a variety of stimuli cause a rapid increase in polyamine synthesis by increasing an enzyme ornithine decarboxylase required for the biosynthetic pathway of protein synthesis. difluoromethyl ornithine is a selective inhibitor of this enzyme and hence arrests cell replication strikingly. its effects on thyroid gland are studied with respect to change in animal's weight and levels of triiodothyronine, thyroxine and thyroid stimulating hormone. the study was conducted to evaluate the inhibitory effe ... | 2009 | 20524478 |
| genotypic characterization of acanthamoeba spp. causing ocular infections in swedish patients: identification of the t15 genotype in a case of protracted keratitis. | the genus acanthamoeba represents free-living amoebae typically widespread in soil and water. it consists of more than 20 known species representing 15 genotypes of different pathogenicity and virulence. the aim of the study was the genotypic characterization of acanthamoeba spp. isolated from human keratitis cases in sweden. thirteen amoeba isolates obtained from contact lens users with suspected acanthamoeba keratitis (ak) were subjected to polymerase chain reaction amplification and subsequen ... | 2010 | 20524785 |
| surgery for malignant pleural mesothelioma. | the role of surgery for malignant pleural mesothelioma encompasses the need for rapid diagnosis, preoperative staging and surgical resection, and also the need for a greater biological understanding of this rare and aggressive malignancy. in the multimodality treatment paradigm, the goal of surgery is to provide a macroscopic complete resection (i.e., complete removal of all grossly visible tumor). two operations have evolved: extrapleural pneumonectomy and pleurectomy/decortication. the former ... | 2010 | 20524919 |
| [sentinel lymph node biopsy in patients with melanoma]. | the incidence of melanoma is currently increasing worldwide. one of the factors influencing disease prognosis is the presence of regional lymph node metastases. sentinel lymph node biopsy attempts to identify subclinical lymph node metastasis as a prognostic factor in the disease. the aim of this study was to analyze differences between patients with melanoma for whom positive or negative results were obtained in sentinel lymph node biopsy and to assess the impact of the technique on disease pro ... | 2010 | 20525486 |
| technical feasibility of laparoscopic total mesorectal excision for patients with low rectal cancer after concurrent radiation and chemotherapy with bevacizumab plus folfox. | this study aimed to evaluate the technical feasibility of laparoscopic total mesorectal excision (tme) for the treatment of low rectal cancer after concurrent chemoradiation therapy (ccrt) with bevacizumab and folfox. | 2011 | 20526625 |
| analysis of serum lipid profiles, metal ions and thyroid hormones levels abnormalities in beta-thalassaemic children of bangladesh. | to assess the serum lipid profile of cardiovascular disease free male and female children with beta-thalassaemia. levels of zinc, copper and magnesium in the serum were also determined along with the thyroid profile. | 2010 | 20527607 |
| noxious colorectal distention in spinalized rats reduces pseudorabies virus labeling of sympathetic neurons. | the retrograde transsynaptic tracer pseudorabies virus (prv) has been widely used as a marker for synaptic connectivity in the spinal cord. notably, the prv-152 construct expresses enhanced green fluorescent protein (egfp). we recently reported a significant attenuation of prv-152 labeling of the intermediolateral cell column (iml) and celiac ganglia after complete t4 spinal cord transection versus sham injury in rats at 96 h after prv-152 inoculation of the left kidney. here we found a signific ... | 2010 | 20528165 |
| a case report of subacute thyroiditis during pregnancy: difficulties in differential diagnosis and changes in cytokine levels. | introduction. thyroid dysfunction during pregnancy may result in both maternal and neonatal complications. subacute thyroiditis (sat) is an extremely rare cause of both hyper- and hypothyroidism in pregnant women. case description. a case of first trimester sat is presented. diagnosis of sat was based on fine-needle aspiration biopsy. the disease resolved spontaneously without need for prednisone administration but a hypothyroid phase treated with t4 throughout pregnancy occurred. the pregnancy ... | 2011 | 20528573 |
| a comparison of the effect on qt interval between thiamylal and propofol during anaesthetic induction*. | summary: the aim of this study was to determine the effect of thiamylal and propofol on heart rate-corrected qt (qtc) interval during anaesthetic induction. we studied 50 patients undergoing lumbar spine surgery. patients were administered 3 microgxkg(-1) fentanyl and were randomly allocated to receive 5 mgxkg(-1) thiamylal or 1.5 mgxkg(-1) propofol as an induction agent. tracheal intubation was performed after vecuronium administration. heart rate, mean arterial pressure, bispectral index score ... | 2010 | 20528837 |
| effect of thyroid statuses on sodium/iodide symporter (nis) gene expression in the extrathyroidal tissues in mice. | abstract: | 2010 | 20529371 |
| the effects of stimulating lower leg muscles on the mechanical work and metabolic response in functional electrically stimulated pedaling. | functional electrical stimulation (fes) pedaling with the muscles of the upper leg has been shown to provide benefit to spinal cord injured (sci) individuals. fes pedaling with electrical stimulation timing patterns that minimize the stress-time integral of activated muscles has been shown to increase the work individuals can perform during the exercise compared to existing fes stimulation timing patterns. activation of the lower leg muscles could further enhance the benefit of fes pedaling by i ... | 2010 | 20529755 |
| inhibition of thyroid hormone release from cultured amphibian thyroid glands by methimazole, 6-propylthiouracil, and perchlorate. | thyroid gland explant cultures from prometamorphic xenopus laevis tadpoles were evaluated for their utility in assessing chemicals for thyroid hormone (th) synthesis disruption. the response of cultured thyroid glands to bovine thyroid stimulating hormone (btsh) and the th synthesis inhibitors methimazole, 6-propylthiouracil, and perchlorate was determined. thyroid glands continuously exposed for 12 days to graded concentrations of btsh released thyroxine (t4) in a dose-dependent manner. over ti ... | 2010 | 20530234 |
| [the beta-helical domain of bacteriophage t4 controls the folding of the fragment of long tail fibers in a chimeric protein]. | the key stage of the infection of the escherichia coli cell with bacteriophage t4, the binding to the surface of the host cell, is determined by the specificity of the long tail fiber proteins of the phage, in particular, gp37. the assembly and oligomerization of this protein under natural conditions requires the participation of at least two additional protein factors, gp57a and gp38, which strongly hinders the production of the recombinant form of gp37. to overcome this problem, a modern prote ... | 2010 | 20531477 |
| abcb1/mdr1 gene polymorphisms as a prognostic factor in colorectal cancer. | to analyse the single-nucleotide polymorphisms (snps): abcb1(1236c>t), abcb1(2677g>t/a), abcb1(3435c>t) and haplotypes in the abcb1/mdr1 gene, which could contribute to genetic risk of colorectal cancer (crc). disease association between the abcb1/mdr1 genotype, allele, haplotype frequencies and histological features, such as tnm classification, localization of primary carcinoma, grade of malignancy, histological type of tumour, lymphoid infiltration and vessel invasion were estimated. in this s ... | 2010 | 20533057 |
| chronic kidney disease-epidemiology formula and model for end-stage liver disease score in the assessment of renal function in candidates for liver transplantation. | assessment of renal function in patients with end-stage liver disease (esld) awaiting liver transplantation (olt) is critical. various conditions may cause renal damage in esld. renal and liver functions are intertwined due to splanchnic hemodynamic relationships; renal failure rarely occurs in patients without advanced decompensated cirrhosis. the recent literature suggests that evaluation of renal function should include an assessment of liver function. the aim of this study was to evaluate di ... | 2010 | 20534268 |
| investigations of thyroid hormones and antibodies in obesity: leptin levels are associated with thyroid autoimmunity independent of bioanthropometric, hormonal, and weight-related determinants. | obesity can alter the thyroid hormone status as a result of a dysregulated endocrine loop between the hypothalamo-pituitary unit and adipose tissue. the adipocytokine leptin has been shown to promote autoimmunity; hence, we aimed to clarify whether leptin excess of obesity could increase the susceptibility to develop autoimmune thyroid disease (aitd). | 2010 | 20534769 |
| [protective effect of breviscapine on cardiac function in children after cardiopulmonary bypass undergoing open heart surgery]. | to assess the condition of myocardial injury after cardiopulmonary bypass (cpb) and the effects of breviscapine (bvc) on cardiac function in children undergoing open heart surgery. | 2010 | 20535923 |
| [significance of ipsilateral adrenalectomy in surgery for renal cell carcinoma]. | the aim of this study is to analyze the incidence of involvement of ipsilateral adrenal gland from renal cell carcinoma and assess the actual significance of ipsilateral adrenalectomy at nephrectomy. | 2010 | 20535986 |
| congenital hypothyroidism. | congenital hypothyroidism (ch) occurs in approximately 1:2,000 to 1:4,000 newborns. the clinical manifestations are often subtle or not present at birth. this likely is due to trans-placental passage of some maternal thyroid hormone, while many infants have some thyroid production of their own. common symptoms include decreased activity and increased sleep, feeding difficulty, constipation, and prolonged jaundice. on examination, common signs include myxedematous facies, large fontanels, macrogl ... | 2010 | 20537182 |
| eosinophilic vasculitis of the spinal cord associated with churg-strauss syndrome. | eosinophilic vasculitis has been described as part of churg-strauss syndrome (css), but it also affects the central nervous system in <10% of cases. however, spinal cord involvement in css has not been reported. we report a patient with myelopathic symptoms, with a two-year history of asthma. laboratory tests revealed leukocytosis, with 31.7% eosinophils. a chest computed tomographic scan and radiography showed patchy bilateral areas of consolidation, predominantly involving the peripheral regio ... | 2010 | 20538303 |
| medium-term results of neoadjuvant systemic chemotherapy using irinotecan, 5-fluorouracil, and leucovorin in patients with locally advanced rectal cancer. | the aim of this study was to evaluate the usefulness of neoadjuvant systemic chemotherapy using irinotecan, 5-fu, and leucovorin (lv) for the treatment of locally advanced rectal cancer, which was a powerful ploychemotherapy in those days in japan. | 2010 | 20538422 |
| novel recombinant engineered gp41 n-terminal heptad repeat trimers and their potential as anti-hiv-1 therapeutics or microbicides. | peptides derived from n-terminal heptad repeat (nhr) of the hiv-1 gp41 are generally poor inhibitors of hiv-1 entry, because they tend to aggregate and do not form a trimeric coiled-coil. in this study, we have fused portions of gp41 nhr, e.g. n36 or n28, to the t4 fibritin trimerization domain, foldon (fd), thus constructing novel nhr trimers, designated n36fd or n28fd, which could be expressed in escherichia coli cells. the purified n36fd and n28fd exhibited sds-resistant trimeric coiled-coil ... | 2010 | 20538590 |
| synthesis, biological properties and anti-hiv-1 activity of new pyrimidine p1,p2-dinucleotides. | new homo- and hetero-p(1),p(2)-dinucleotides were prepared with the use of multistep procedures starting from the monophosphates of 3'-fluoro-2-thiothymidine, 3'-fluoro-4-thiothymidine, azt and 1-[(2-hydroxyethoxy)-methyl-5-propyl-6-phenylselenenyl]uracil. anti-hiv properties of the synthesized p(1),p(2)-dinucleotides were evaluated against laboratory syncytia inducing strain hiv-1 in cem-t4 cells. anti-hiv activities were in the range of 5-45 nm, and therapeutic indexes were higher than 4666-14 ... | 2010 | 20544533 |
| determinants of affinity and activity of the anti-sigma factor asia. | the asia protein is a t4 bacteriophage early gene product that regulates transcription of host and viral genes. monomeric asia binds tightly to the sigma(70) subunit of escherichia coli rna polymerase, thereby inhibiting transcription from bacterial promoters and phage early promoters and coactivating transcription from phage middle promoters. results of structural studies have identified amino acids at the protomer-protomer interface in dimeric asia and at the monomeric asia-sigma(70) interface ... | 2010 | 20545305 |
| neutrophil oxidative metabolism and haemogram of sheep experimentally infected with haemonchus contortus and supplemented with selenium and vitamin e. | the objective of this study was to evaluate neutrophil oxidative metabolism and haemogram in sheep experimentally infected with haemonchus contortus and supplemented with selenium and vitamin e. twenty male corriedale sheep were utilised and distributed into four experimental groups each with five animals infected with larvae: g1--supplemented with sodium selenite, 0.2 mg/kg body weight (bw) given intramuscularly (im); g2--supplemented with sodium selenite and vitamin e, 0.2 mg/kg bw and 2000 iu ... | 2010 | 20546075 |
| [oral cancer surgery and oral cutaneous fistulas: risk factors]. | to quantify the oral cutaneous fistulae after surgery and to identify possible risk factors. | 2010 | 20549096 |
| anterior approaches to the cervicothoracic junction: a study on the surgical accessibility of three different corridors based on the ct images. | to determine the location of left brachiocephalic vein (bcv) and tracheal bifurcation (tb) relative to the vertebral levels, and to ascertain the accessibility of three different corridors (c1: between the esophagus and trachea medially and the carotid sheath laterally, c2: between the right bcv and the brachiocephalic artery, and c3: between the ascending aorta and superior vena cava) for preoperative planning. from august 2008 to april 2009, normal chest ct scans of 150 subjects ranging in age ... | 2010 | 20549258 |
| changes in monoterpene emission rates of quercus ilex infested by aphids tended by native or invasive lasius ant species. | the emission of volatile organic compounds (vocs) depends on temperature and light. other factors such as insect herbivory also may modify voc emission. in particular, aphid feeding promotes the release of new compounds and changes the composition of plant volatile blends. given that some aphids are tended by ants, we investigated whether ants change the emission of vocs indirectly through attendance on aphids. the effect of lachnus roboris aphids and two different tending ant species on terpene ... | 2010 | 20549328 |
| brominated diphenyl ether (bde) levels in liver, adipose, and milk from adult and juvenile rats exposed by gavage to the de-71 technical mixture. | brominated diphenyl ethers (bdes) are used as flame retardants in consumer products. rodent studies indicate that the liver, thyroid, and nervous system of developing animals are targets of bdes. to explore the relationship between exposure and health in developing animals, bde accumulation in adult and juvenile rats was examined in conjunction with changes in liver weight and serum thyroxine (t4). adult (f0) rats received the commercial bde mixture de-71 by gavage at doses of 0.5, 5, and 25 mg ... | 2010 | 20549633 |
| sentinel lymph node biopsy for papillary thyroid cancer: 12 years of experience at a single institution. | the purpose of this study was to report our experience with sentinel lymph node dissection (slnd) for papillary thyroid carcinoma, to evaluate the feasibility and safety of the procedure, and to examine its potential utility as a guide for central neck dissection. | 2010 | 20552407 |
| isolation and identification of acanthamoeba species related to amoebic encephalitis and nonpathogenic free-living amoeba species from the rice field. | isolation and characterization of the clinically relevant amphizoic amoebas in vegetated farmlands, which may present a risk to farmers' health. | 2010 | 20553339 |
| altered thyroid hormones and behavioural change in a sub-population of rats following chronic constriction injury. | hypothyroidism is associated with a disturbance of behaviour and mood. there are also individuals, not classified as hypothyroid, with low to 'low normal' thyroid hormone levels and normal thyroid-stimulating hormone (tsh) levels who have mood and behavioural changes. as the peripheral thyroid hormones decrease, tsh is expected to increase. however, there are a number of physiological mechanisms known to suppress tsh. in the present study, we report on thyroid hormone regulation in a rat model o ... | 2010 | 20553369 |
| treatment of cancer-related chest wall pain using spinal cord stimulation. | it has been estimated that 15% to 40% of chronic cancer pain has a neuropathic component, and this type of pain often responds poorly to opioids. in an attempt to provide increased pain relief for patients with intractable cancer pain, unconventional agents and interventional management approaches have received considerable attention. spinal cord stimulation (scs) has been used with increased frequency for the treatment of intractable cancer pain. | 2010 | 20555037 |
| platysma myocutaneous flap for oral cavity reconstruction. | a retrospective study was conducted to assess outcomes of reconstruction of the oral cavity with the platysma myocutaneous flap, in terms of flap survival, complications, and quality of life. included were 10 patients with squamous cell carcinoma (stage t1 to t4; nodal status n0 to n2) of the oral cavity who were treated between 2002 and 2006. each patient underwent tumor resection, modified radical neck dissection, and primary reconstruction with a platysma myocutaneous flap. operating time, le ... | 2010 | 20556740 |
| direct fluoroscopic drainage of symptomatic post-traumatic syringomyelia. a case report and review of the literature. | summary: first described in 1928, percutaneous aspiration of syringomyelia is infrequently performed to aid in diagnosis and surgical management. we describe a case of post traumatic syringomyelia successfully treated with direct fluoroscopic drainage with substantial resolution of syrinx-related neurologic symptoms. the patient is a 36-year-old man involved in a motorcycle accident who sustained multiple vertebral fractures resulting in dense paraplegia below t4, ultimately treated with multile ... | 2009 | 20557748 |
| thyroid hormone receptor alpha1 downregulation in postischemic heart failure progression: the potential role of tissue hypothyroidism. | thyroid hormone (th) signaling is altered in response to various stresses including myocardial ischemia. the present study investigated potential implication of th signaling in the pathophysiology of postischemic remodeling. acute myocardial infarction was induced in rats by coronary artery ligation (ami). after 34 weeks, 6 animals were on congestive heart failure (chf) as indicated by measurements in lung and right ventricular weight. 7 animals were in compensated state (non-chf) and 8 sham-ope ... | 2010 | 20560106 |
| [the role of the "heil- und pflegeanstalt" (state hospital) günzburg in the context of the "aktion-t4"]. | in the context of the national socialist "aktion-t4" approximately 70,000 people with mental illness and mental handicap in germany were killed. the "heil- und pflegeanstalt" (mental hospital) günzburg was a so-called bavarian "sammelanstalt" during this period. | 2010 | 20560117 |
| [spontaneous spinal subdural and epidural haematoma in a pregnant patient]. | we report a pregnant woman who developed non-traumatic spinal subdural and epidural hematoma. a 31-year-old woman at 28 weeks of gestation developed progressive ascending paralysis. mri suggested the presence of spinal subdural hematoma at t4-6 and spinal epidural hematoma at t4-9. an emergency cesarean section followed by spinal decompression was performed 60 hours after the onset. the patient's neulogical function recovered completely after the surgey. | 2010 | 20560387 |
| [adult male with tubulointerstitial nephritis and uveitis syndrome complicated with thyroiditis]. | renal dysfunction was detected by routine medical examination in a 46-year-old man (blood urea nitrogen : 26 mg/dl, creatinine : 2.4 mg/dl and moderate proteinuria). a few weeks later, he visited a local ophthalmologist complaining of left eye pain and red eye. he was diagnosed as left uveitis, prescribed eye-drops and referred to our hospital for further examination. at the first visit, test results pointed to renal dysfunction and a high level of thyroid hormones (creatinine : 1.8 mg/dl, free ... | 2010 | 20560474 |