| estimated gene frequencies of genestar markers and their size of effects on meat tenderness, marbling, and feed efficiency in temperate and tropical beef cattle breeds across a range of production systems. | the objectives of this study were to use genotypes for 12 commercially available genestar gene markers on 12,330 animals to estimate gene frequencies of the markers across a range of beef cattle breeds and to determine the effects of these markers on target traits using a subset of animals with both genotypic and phenotypic data (n = 9,414) for at least one trait. tenderness markers (t1, t2, t3, t4) were assessed against shear force of 2 muscles, marbling markers (m1, m2, m3, m4) were assessed a ... | 2010 | 20154168 |
| [effectiveness of concomitant therapy with s-1, nedaplatin, and radiation for laryngeal cancer]. | laryngeal cancer occurs more frequently in head and neck cancers, so there are a number of reports regarding the treatment results,wherein the therapeutic strategy and results are stable to some extent. however, due to the spread of chemoradiotherapy, there are differences in the larynx preservation rates for t2 and t3 cases, depending on the facility. our department has been administering chemoradiotherapy for advanced cancer based on the perspective of conserving the organ and the function. we ... | 2010 | 20154477 |
| structure of bacteriophage t4 endonuclease ii mutant e118a, a tetrameric giy-yig enzyme. | coliphage t4 endonuclease ii (endoii), encoded by gene dena, is a small (16 kda, 136 aa) enzyme belonging to the giy-yig family of endonucleases, which lacks a c-terminal domain corresponding to that providing most of the binding energy in the structurally characterized giy-yig endonucleases, i-tevi and uvrc. in vivo, it is involved in degradation of host dna, permitting scavenging of host-derived nucleotides for phage dna synthesis. endoii primarily catalyzes single-stranded nicking of dna; 5- ... | 2010 | 20156453 |
| late occurrence of cervicothoracic ossification of posterior longitudinal ligaments in a surgically treated thoracic opll patient. | ossification of the posterior longitudinal ligament (opll) in the thoracic spine is rare, even in the far east. a 45-year-old female presented with a 4-month history of progressive motor weakness in the lower extremities, numbness below the midthoracic area, and spastic gait disturbance. neuroradiological examinations revealed massive oplls at the t4-t6 levels with severe anterior compression of the spinal cord. anterior decompressive corpectomies with bone grafts were performed from t4 to t6 us ... | 2010 | 20157380 |
| modeling the electrostatic signature of single enzyme activity. | charge sensors based on nanoscale field-effect transistors are a promising new tool to probe the dynamics of individual enzymes. however, it is currently unknown whether the electrostatic signals associated with biological activity exceed detection limits. we report calculations of electrostatic signatures of two representative enzymes, deoxyribonuclease i and t4 lysozyme. our simulations reveal that substrate binding to deoxyribonuclease and internal dynamics of lysozyme are detectable at the s ... | 2010 | 20163162 |
| effects of maize (zea mays l.) silage feeding on dry matter intake and milk production of dairy buffalo and cattle in tarai, nepal. | to identify the effects of whole crop maize silage (ms) as a substitute for rice straw (rs) on feed intake and milk production of mid-late lactating buffalo and cattle in tarai, nepal, eight murrah and eight jersey-hariana were fed the basal diet, rs (ad libitum) with concentrate (0.68% of bodyweight [bw] on a dry matter [dm] basis). a 4 x 4 latin square design experiment was conducted in each animal species with graded levels of ms substitution for rs (0%, t1; 33%, t2; 67%, t3 and 100%, t4). th ... | 2009 | 20163602 |
| thymidylate synthase germline polymorphisms in rectal cancer patients treated with neoadjuvant chemoradiotherapy based on 5-fluorouracil. | chemoradiotherapy using 5-fluorouracil has shown to be effective treatment for rectal cancer. thymidylate synthase (ts) is an important target enzyme for the fluoropyrimidines. however, the predictive role of ts levels in early stage rectal cancer is not yet well understood. we analyzed the value of ts gene polymorphisms as a predictive marker in patients with stage ii and iii rectal cancer treated with preoperative concomitant radiotherapy and fluoropyrimidine-based chemotherapy. | 2010 | 20165956 |
| conditional survival after surgical treatment of melanoma: an analysis of the surveillance, epidemiology, and end results database. | survival curves following surgical treatment of cutaneous melanoma are heavily influenced by early deaths. therefore, survival estimates may be misleading for long-term cancer survivors. we examined whether conditional survival (cs) is more accurate in predicting long-term melanoma survival. | 2010 | 20165985 |
| does breathing disturb coordination in butterfly? | this study quantified the effects of breathing compared to non-breathing and "race pace" on arm to leg coordination in the butterfly stroke. twelve elite male swimmers swam at four paces: 400 m, 200 m, 100 m and 50 m. the arm and leg stroke phases were identified by video analysis to calculate the total time gap (ttg), which is the sum of t1 (hands' entry in the water/high point of first kick), t2 (beginning of the hands' backward movement/low point of first kick), t3 (hands' arrival in a vertic ... | 2010 | 20166004 |
| light-induced local heating for thermophoretic manipulation of dna in polymer micro- and nanochannels. | we present a method for making polymer chips with a narrow-band near-infrared absorber layer that enables light-induced local heating of liquids inside fluidic micro- and nanochannels fabricated by thermal imprint in polymethyl methacrylate. we have characterized the resulting liquid temperature profiles in microchannels using the temperature dependent fluorescence of the complex [ru(bpy)(3)](2+). we demonstrate thermophoretic manipulation of individual yoyo-1 stained t4 dna molecules inside mic ... | 2010 | 20166745 |
| in vitro evaluation of cytotoxicity of engineered carbon nanotubes in selected human cell lines. | in this study, we used a systematic approach to study and compare the in vitro cytotoxicity of selected engineered carbon nanotubes (cnts) to test cell lines including human skin keratinocytes, lung cells and lymphocytes. results of fluorescein diacetate (fda) uptake in t4 lymphocyte a3 cells indicated cytotoxicity caused by single-walled carbon nanotubes (swcnts) at concentrations of 2, 5 and 10ppm. at 2ppm, the swcnt treatment group retained 71.3% viability compared to the pbs control group. a ... | 2010 | 20167353 |
| hemodynamic effects of atracurium and cisatracurium and the use of diphenhydramine and cimetidine. | since atracurium can cause hypotension in humans, the hemodynamic effects of atracurium and cisatracurium as well as the hemodynamic protection of diphenhydramine and cimetidine were investigated in rats. | 2010 | 20169263 |
| neo-adjuvant chemo-radiation of rectal cancer with volumetric modulated arc therapy: summary of technical and dosimetric features and early clinical experience. | to report about initial technical and clinical experience in preoperative radiation treatment of rectal cancer with volumetric modulated arcs with the rapidarc (ra) technology. | 2010 | 20170490 |
| [waiting times in breast disease clinics and psychological well-being: speedy care is better care]. | to examine the effect of diagnostic speed and the waiting time before surgery on the psychological well-being of patients in breast disease clinics. | 2010 | 20170572 |
| analysis of the dna translocation and unwinding activities of t4 phage helicases. | helicases are an important class of enzymes involved in dna and rna metabolism that couple the energy of atp hydrolysis to unwind duplex dna and rna structures. understanding the mechanism of helicase action is vital due to their involvement in various biological processes such as dna replication, repair and recombination. furthermore, the duplex dna unwinding property of this class of enzymes is closely related to their single-stranded dna translocation. hence the study of its translocation pro ... | 2010 | 20170733 |
| segmental ureterectomy can safely be performed in patients with transitional cell carcinoma of the ureter. | to date no study to our knowledge has compared cancer control outcomes of segmental ureterectomy relative to nephroureterectomy, which represents the standard of care for ureteral transitional cell carcinoma. we compared cancer specific mortality rates according to surgery type (nephroureterectomy vs segmental ureterectomy) in a large population based cohort of patients with ureteral transitional cell carcinoma. | 2010 | 20171666 |
| minimally invasive circumferential spinal decompression and stabilization for symptomatic metastatic spine tumor: technical case report. | metastatic epidural spinal cord compression is a potentially devastating complication of cancer and is estimated to occur in 5% to 14% of all cancer patients. it is best treated surgically. minimally invasive spine surgery has the potential benefits of decreased surgical approach-related morbidity, blood loss, hospital stay, and time to mobilization. | 2010 | 20173535 |
| biomechanical comparison of costotransverse process screw fixation and pedicle screw fixation of the upper thoracic spine. | to compare the biomechanics of costotransverse process screw fixation with those of pedicle screw fixation in a cadaveric model of the upper thoracic spine. | 2010 | 20173568 |
| d-type cyclins in superficial and muscle-invasive bladder urothelial carcinoma: correlation with clinicopathological data and prognostic significance. | to elucidate the role of d-type cyclins in both superficial (ta-t1) and muscle-invasive (t2-t4) urothelial carcinomas (ucs), investigating their potential prognostic usefulness. | 2010 | 20174823 |
| the impact of isolated maternal hypothyroxinemia on perinatal morbidity. | to determine whether maternal hypothyroxinemia during early pregnancy is associated with adverse perinatal outcomes. | 2009 | 20175339 |
| [improvement of lasting effects in outpatient pulmonary rehabilitation with special regard to exercise therapy and sports]. | the aim of this study was to evaluate the effects of outpatient medical rehabilitation (omr) mainly composed of exercise therapy and sports for patients with asbestosis. following the hamburg model, the omr focuses on keeping up lasting effects. | 2010 | 20178059 |
| prognostic value of preoperative clinical staging assessed by computed tomography in resectable gastric cancer patients: a viewpoint in the era of preoperative treatment. | in the era of pre- or perioperative therapy for gastric cancer, clinical staging before treatment appears to be increasingly important for prognosis, yet there are no data on the subject for resectable gastric cancer patients. | 2010 | 20179530 |
| examination of the efficacy of acute l-alanyl-l-glutamine ingestion during hydration stress in endurance exercise. | abstract: | 2010 | 20181080 |
| acute myocardial infarction as the first presentation of thyrotoxicosis in a 31-year old woman - case report. | abstract: : a 31-year old woman, previously fit & well was admitted with pressing retrosternal chest pain and palpitations of sudden onset. her body weight was normal (bmi 20.5 kg/m2) and there was no significant family history of cardiac disease. she smoked, however, about 15 cigarettes a day and she had been taking combined oral contraceptive pill (cilest(r)) for about three years. on admission she appeared sweaty and in pain, blood pressure 130/70 mmhg, heart rate about 110/min, mild lid-lag ... | 2010 | 20181115 |
| synthesis and activity of modified cytidine 5'-monophosphate probes for t4 rna ligase 1. | we describe the synthesis of a series of unique base modified ligation probes such as p(5')c-4-ethylenediamino 3, p(5')c-4-biotin 4, and pre-adenylated form a(5')pp(5')c-4-biotin 6 and tested their biological activity with t4 rna ligase 1 using a standard pcp probe 1 as a control. the intermolecular ligation assay was developed using a 5'-fam labeled 24 mer single-stranded (ss) rna and the average ligation efficiencies for pcp 1, p(5')c-4-ethylenediamino 3, p(5')c-4-biotin 4, and pre-adenylated ... | 2009 | 20183582 |
| delineation of differential temporal relations between specific eating and anxiety disorders. | this study examined the temporal sequencing of eating and anxiety disorders to delineate which anxiety disorders increase eating disorder risk and whether individuals with eating disorders are at greater risk for particular anxiety disorders. the sample was drawn from the oregon adolescent depression project. temporal relations between specific eating and anxiety disorders were examined after controlling for relevant variables (e.g., mood disorders, other anxiety disorders) over 14 years. after ... | 2010 | 20185151 |
| impact of the new lung cancer staging system for a predominantly advanced-disease patient population. | to investigate the feasibility and clinical impact of the 7th edition of the "tumor, node, metastasis" (tnm) classification scheme in lung cancer as proposed by the international association for the study of lung cancer (iaslc) for non-small cell lung cancer. | 2010 | 20186024 |
| free fibula osteocutaneous flap for primary reconstruction of t3-t4 gingival carcinoma. | lower gingival squamous cell carcinoma (scc) frequently invades the mandibular bone and buccal or lingual oral mucosa. in the concept of en bloc surgery of malignant tumors, it is advisable to prefer segmental mandibulectomy for t3-t4 lower gingival carcinoma that had radiologic bone involvement and resection of soft tissue on the buccal or lingual side with negative border of margin. consequential defects of oral mucosa and mandible need immediate reconstruction to provide the maximum probabili ... | 2010 | 20186097 |
| reference values for vertebral shape in young chinese women: implication for assessment of vertebral deformity. | the race- and sex-specific reference values for vertebral shape are important to determine the prevalence of osteoporotic vertebral fracture. however, these reference values are absent in chinese women. in the present study, the anterior, middle and posterior heights and the ratios of these heights were measured from 14 vertebral bodies (t4-l5) in 60 premenopausal chinese women (aged 19-25 years). cutoff values were set as standard deviations (3 and 3.5 sd) and percentages (15 and 20%) below the ... | 2010 | 20186444 |
| chemoradiotherapy for locoregionally advanced squamous cell carcinoma of the base of tongue. | our aim was to report the outcomes of base of tongue cancers treated with chemoradiotherapy. | 2010 | 20187015 |
| replication of a universal nucleobase provides unique insight into the role of entropy during dna polymerization and pyrophosphorolysis. | most models accounting for the efficiency and fidelity of dna polymerization invoke the use of either hydrogen bonding contacts or complementarity of shape and size between the formed base pair. this report evaluates these mechanisms by quantifying the ability of a high-fidelity dna polymerase to replicate 5-nitroindole, a purine mimetic devoid of classic hydrogen bonding capabilities. 5-nitp acts as a universal nucleotide since it is incorporated opposite any of the four natural nucleobases wit ... | 2010 | 20187654 |
| t4 plus t3 treatment in children with hypothyroidism and inappropriately elevated thyroid-stimulating hormone despite euthyroidism on t4 treatment. | to evaluate the effect of addition of t3 to l-t4 treatment in children with congenital hypothyroidism (ch) who have inappropriately elevated thyroid-stimulating hormone (tsh) levels despite high normal serum t4 levels on l-t4 treatment. | 2010 | 20190547 |
| serum thyrotropin concentration is an early marker of normalization of low triiodothyronine syndrome in aged hospitalized patients after discharge. | to assess short-term spontaneous evolution of alterations in thyroid function tests in aged hospitalized patients after discharge. | 2010 | 20190556 |
| pre-treatment hemoglobin levels are important for bladder carcinoma patients with extravesical extension undergoing definitive radiotherapy. | to evaluate prognostic factors affecting local control (lc), distant metastases-free survival (dmfs) and overall survival (os) in bladder carcinoma patients undergoing extravesical extension. | 2009 | 20192602 |
| surgical treatment of iiib-t4 lung cancer invading left atrium and great vessels. | iiib-t(4) non-small cell lung cancer (nsclc) is commonly considered a contraindication to surgery, although chemo-radiotherapy also achieves a poor survival rate. we reviewed our experience with t(4) nsclc patients who underwent surgery to explore the indications and prognostic factors of surgical treatment of lung cancer invading the left atrium and great vessels. | 2010 | 20193242 |
| expressed sequence tags-based identification of genes in a biocontrol strain trichoderma asperellum. | trichoderma asperellum, a filamentous soil fungus, is an effective biocontrol agent against many fungal plant pathogenic species. in the present study, we investigated the biological control properties of the strain t. asperellum t4. t. asperellum fermentation products significantly decreased the ability of rhizoctonia solani and sclerotinia sclerotiorum to infect rice and soybean, respectively. to further elucidate the biocontrol mechanisms of t. asperellum at the molecular level, a cdna librar ... | 2010 | 20195770 |
| newborn screening strategies for congenital hypothyroidism: an update. | it is the purpose of this article to briefly review the initial development and subsequent evolution of newborn screening programs to detect infants with congenital hypothyroidism (ch) and then to provide an update of the advantages and disadvantages of the main test strategies. pilot programs began screening newborn populations in north america in the mid-1970s using either primary thyroxine (t4)-follow-up thyroid stimulating hormone (tsh) or primary tsh testing. many programs in the united sta ... | 2010 | 20195902 |
| [effect of ulinastatin on perioperative inflammatory response to coronary artery bypass grafting with cardiopulmonary bypass]. | to determine the effect of ulinastatin on perioperative inflammatory response to coronary artery bypass grafting (cabg) with cardiopulmonary bypass (cpb). | 2010 | 20197607 |
| rapid construction and characterization of synthetic antibody libraries without dna amplification. | we report on a simple method to rapidly generate very large libraries of genes encoding mutant proteins without the use of dna amplification, and the application of this methodology in the construction of synthetic immunoglobulin variable heavy (v(h)) and light (v(kappa)) libraries. four high quality, chemically synthesized polynucleotides (90-140 bases) were annealed and extended using t4 dna polymerase. following electroporation, >10(9) transformants could be synthesized within 1 day. fusion t ... | 2010 | 20198660 |
| mucosal melanoma of the nose and paranasal sinuses, a contemporary experience from the m. d. anderson cancer center. | sinonasal mucosal melanoma is a rare disease associated with a very poor prognosis. because most of the series extend retrospectively several decades, we sought to determine prognostic factors and outcomes with recent treatment modalities. | 2010 | 20198705 |
| effects of growth hormone and thyroxine replacement therapy on insulin signaling in ames dwarf mice. | ames dwarf (prop1(df), df/df) mice lack growth hormone (gh), prolactin, and thyrotropin and live remarkably longer than their normal siblings. significance of reduced activity of the somatotropic and thyroid axes during development and adulthood on longevity are unknown. because enhanced insulin sensitivity and reduced insulin levels are among likely mechanisms responsible for increased longevity in these mutants, we compared the effects of gh and thyroxine (t4) replacement on various parameters ... | 2010 | 20200088 |
| the biochemical effectiveness of n-acetylcysteine in experimental spinal cord injury in rats. | in this study, we investigated the biochemical effectiveness of methylprednisolone, n-acetylcysteine (nac) and methylprednisolone combined with nac treatment in experimental spinal cord injury in rats. | 2010 | 20209390 |
| thyroid hormone changes in early kidney transplantation and its correlation with delayed graft function. | thyroid hormones affect kidney function and may alter with changes in kidney function, as well. we evaluated changes in serum levels of triiodothyronine (t3), thyroxin (t4), and thyroid-stimulating hormone (tsh) early after kidney transplantation and their relationship with delayed graft function (dgf). | 2010 | 20209453 |
| retrospective long-term results and prognostic factors of postoperative treatment for uicc stages ii and iii rectal cancer. | to retrospectively evaluate 5-year local control, disease-free survival, cancer-specific survival and overall survival rates in patients with uicc stages ii and iii rectal cancer treated with adjuvant therapy and especially to analyze the impact of some prognostic factors on clinical outcome at univariate and multivariate analyses. | 2009 | 20210228 |
| phase ii study of preoperative chemoradiotherapy (crt) with irinotecan plus s-1 in locally advanced rectal cancer. | the aim of this study is to evaluate the efficacy and safety of preoperative radiation therapy combined with s-1 and irinotecan (si) in larc. | 2010 | 20211505 |
| [effect of puerain preconditioning on cytokine levels in patients undergoing cardiopulmonary bypass in perioperative period]. | to study the effect and acting mechanism of puerarin preconditioning (pp) on blood level of cytokines in patients undergoing cardiopulmonary bypass (cpb) in perioperative period. | 2009 | 20214329 |
| [steroid replacement therapy for shocks after cardiac surgery]. | a 63-year-old woman who underwent surgery for valve replacement had shocks 2 times. first, 1 postoperative day (pod), she had dyspnea, high grade fever and tacycardia. then, she was intubated again, and needed intraaortic ballon pumping (iabp) support. second, 32 pod, she had dyspnea, loss of consciousness and metabolic acidosis. then she was intubated and needed continuous hemodiafiltration (chdf). in both cases, causes were unknown, but she recovered from shocks after steroid therapy. relative ... | 2010 | 20214348 |
| t4n0m0 nasopharyngeal carcinoma patients: do they have a distinct tumor biology? | to investigate the clinical manifestations and treatment outcomes of non-metastatic t4n0 nasopharyngeal cancer patients, and to compare them with other stage iva subgroups of patients. | 2010 | 20214552 |
| impact of computer-based patient education on illness-specific knowledge and renal function in adolescents after renal transplantation. | interactive cbe holds potential to increase irk and irb in adolescents following transplantation. an experimental design assessed the effect of cbe on irk and renal function in adolescents after transplantation (n = 50, aged 15-20 yr). the igr (n = 26) completed a nine-item questionnaire (9-iq) covering irk and irb prior to completing cbe at three consecutive time points (t0-t2). the cgr (n = 24) received standard care. renal function was determined by gfr 12 months before, at start of intervent ... | 2010 | 20214742 |
| impact of tumor response on survival after radiochemotherapy in locally advanced rectal carcinoma. | in locally advanced rectal adenocarcinoma, preoperative radiochemotherapy induces tumor response. the impact of pathologic tumor response on survival is still debated because of the numerous distinct tumor-response gradings available in the literature and the lack of standardized pathologic approach. the objective of this work was to study the impact of tumor response on survival, according to the 4 main tumor-response gradings available in the literature in locally advanced rectal adenocarcinom ... | 2010 | 20216380 |
| the terminal 5' phosphate and proximate phosphorothioate promote ligation-independent cloning. | function studies of many proteins are waited to develop after genome sequencing. high-throughout technology of gene cloning will strongly promote proteins' function studies. here we describe a ligation-independent cloning (lic) method, which is based on the amplification of target gene and linear vector by pcr using phosphorothioate-modified primers and the digestion of pcr products by lambda exonuclease. the phosphorothioate inhibits the digestion and results in the generation of 3' overhangs, ... | 2010 | 20217896 |
| distinctive clinical and microscopic features of squamous cell carcinoma of oral cavity and lip. | this study was undertaken to gain insight into the distinctive features of squamous cell carcinoma of the lip (lscc) and oral cavity (ocscc). | 2010 | 20219590 |
| a longitudinal comparison of arm morbidity in stage i-ii breast cancer patients treated with sentinel lymph node biopsy, sentinel lymph node biopsy followed by completion lymph node dissection, or axillary lymph node dissection. | long-term shoulder and arm function following sentinel lymph node biopsy (slnb) may surpass that following complete axillary lymph node dissection (clnd) or axillary lymph node dissection (alnd). we objectively examined the morbidity and compared outcomes after slnb, slnb + clnd, and alnd in stage i/ii breast cancer patients. | 2010 | 20221902 |
| p22 coat protein structures reveal a novel mechanism for capsid maturation: stability without auxiliary proteins or chemical crosslinks. | viral capsid assembly and stability in tailed, dsdna phage and herpesviridae are achieved by various means including chemical crosslinks (unique to hk97), or auxiliary proteins (lambda, t4, phi29, and herpesviruses). all these viruses have coat proteins (cp) with a conserved, hk97-like core structure. we used a combination of trypsin digestion, gold labeling, cryo-electron microscopy, 3d image reconstruction, and comparative modeling to derive two independent, pseudoatomic models of bacteriophag ... | 2010 | 20223221 |
| pituitary-adrenal functions in a hereditary hypothyroid (rdw) rat. | the rdw rat is a hereditary hypothyroid strain isolated from wistar-imamichi rats. in the present study, adrenocorticotropic hormone (acth) and corticosterone responses to restraint stress (120 min) were examined in rdw adult male rats. acth response to restraint stress was higher in rdw rats than in hetero control rats. the plasma concentrations of corticosterone were lower in rdw rats than in control rats during the first 30 min after the onset of stress. both acth and corticosterone responses ... | 2010 | 20224173 |
| acute thyroiditis complicating parathyroidectomy. | this report describes a 59-year-old man who presented 10 days after surgery for hyperparathyroidism with pulmonary edema, mildly abnormal echocardiogram, and elevated free t4 level with suppressed thyroid-stimulating hormone level. follow-up documented resolution of the elevated free t4 level with 24-hour thyroid scan and uptake at 60 days showing reduced uptake and normal gland anatomy. previous case reports have been made of thyroiditis at variable time intervals after parathyroidectomy and ar ... | 2010 | 20224309 |
| late-life depressed mood and weight change contribute to the risk of each other. | weight change may be considered an effect of depression. in turn, depression may follow weight change. deteriorations in health may mediate these associations. the objective was to examine reciprocal associations between depressed mood and weight change, and the potentially mediating role of deteriorations in health (interim hospitalizations and incident mobility imitation) in these associations. | 2010 | 20224519 |
| a multicenter assessment of the analytical performance of the routine thyroid panel on the olympus au3000i immunoassay system. | the au3000i thyroid assay panel (tsh, ft4, t4, ft3, t3) was evaluated at four sites in a european multicenter study. the study was designed to assess the basic analytical performance characteristics of the olympus thyroid assays. in addition, a comprehensive assessment of the tsh functional sensitivity was undertaken to challenge the manufacturer's claim of 4th generation assay performance. | 2009 | 20225667 |
| [mobitz type ii block during one-lung ventilation]. | we present a case of mobitz type ii atrioventricular block during one-lung ventilation in a 74-year-old man with lung cancer under anesthesia. premedication with atropine 0.5 mg and midazolam 2 mg intramuscularly were given 30 min before entering the operating room. before anesthesia, his heart rate was 72 beats x min(-1) with normal sinus rhythm and blood pressure was 120/70 mmhg. an epidural catheter was placed at t4-5 interspace and 1.5% mepivacaine was infused (7 ml bolus and 5 ml x hr(-1) t ... | 2010 | 20229756 |
| external beam radiotherapy with endocavitary boost for nasopharyngeal cancer: treatment results and late toxicity after extended follow-up. | to evaluate the long-term outcome after treatment of nasopharyngeal carcinoma and assess late toxicity in a multidisciplinary clinic. | 2010 | 20231060 |
| gene network visualization and quantitative synteny analysis of more than 300 marine t4-like phage scaffolds from the gos metagenome. | bacteriophages (phages) are the most abundant biological entities in the biosphere and are the dominant "organisms" in marine environments, exerting an enormous influence on marine microbial populations. metagenomic projects, such as the global ocean sampling expedition (gos), have demonstrated the predominance of tailed phages (caudovirales), particularly t4 superfamily cyanophages (cyano-t4s), in the marine milieu. whereas previous metagenomic analyses were limited to gene content information, ... | 2010 | 20231334 |
| presence of tumor-infiltrating lymphocytes and a dominant nodule within primary melanoma are prognostic factors for relapse-free survival of patients with thick (t4) primary melanoma: pathologic analysis of the e1690 and e1694 intergroup trials. | lymphocytic infiltration of primary cutaneous melanoma has been demonstrated to be of prognostic significance. tumor infiltrating lymphocytes (tils) were evaluated on histologic sections of pt4 primary cutaneous melanoma from 293 patients, accrued in protocols 1690 and 1694 of the eastern cooperative oncology group. data for the 60-month follow-up were available. statistical analysis of the pathologic data evaluated the correlation of regional lymph node metastasis and response to interferon the ... | 2010 | 20231618 |
| narrowband imaging for early detection of malignant tumors and radiation effect after treatment of head and neck cancer. | to determine the value of narrowband imaging (nbi) screening for the early detection of head and neck squamous cell carcinoma (hnscc) in patients who have received treatment and to assess the impact of radiotherapy on detection rates. | 2010 | 20231639 |
| thyroid hormones induce activation of rat hepatic stellate cells through increased expression of p75 neurotrophin receptor and direct activation of rho. | we have previously shown that hyperthyroidism is detrimental for liver fibrosis and in this study we have investigated the mechanisms regulating triiodothyronine (t3) and l-thyroxine (t4) activation of hepatic stellate cells (hsc). expression of alpha-smooth muscle actin (alphasma) and p75 neurotrophin receptor (p75ntr) was determined by western blot analyses and transient transfection of the promoters. rho activation was assayed using a pull-down assay and by elisa. expression of thyroid hormon ... | 2010 | 20231820 |
| a quick and reliable eeg montage for the detection of seizures in the critical care setting. | obtaining an emergent eeg for the diagnosis of nonconvulsive status epilepticus and conconvulsive seizures in the intensive care unit raises logistic problems in most hospitals. previous studies have looked into the hairline eeg for a broader population than the critically ill, with controversial conclusions. the authors created a montage sufficiently simple to be performed and interpreted by residents and rapidly achievable to meet the time constraints of a busy on-call schedule. seven electrod ... | 2010 | 20234318 |
| prognostic implications of circumferential location of distal rectal cancer. | aim  this study evaluated the prognostic importance of circumferential tumour position of mid and low rectal cancers. method  all ut2, ut3 and ut4 tumours of the middle and lower rectum that underwent total mesorectal excision (tme) with curative intent between 1996 and 2006 were included. the predominant circumferential tumour position (anterior, posterior or circumferential) was defined on preoperative endorectal ultrasound examination (erus). the relationships between tumour position and othe ... | 2011 | 20236143 |
| characteristic effect of an anticancer dinuclear platinum(ii) complex on the higher-order structure of dna. | it is known that a 1,2,3-triazolato-bridged dinuclear platinum(ii) complex, [{cis-pt(nh(3))(2)}(2)(micro-oh)(micro-1,2,3-ta-n (1),n (2))](no(3))(2) (amta), shows high in vitro cytotoxicity against several human tumor cell lines and circumvents cross-resistance to cisplatin. in the present study, we examined a dose- and time-dependent effect of amta on the higher-order structure of a large dna, t4 phage dna (166 kbp), by adapting single-molecule observation with fluorescence microscopy. it was fo ... | 2010 | 20237813 |
| a sensitive ligase-based atp electrochemical assay using molecular beacon-like dna. | a sensitive and selective ligase-based signal-on electrochemical sensing method for adenosine-5'-triphosphate (atp) detection had been developed using molecular beacon (mb)-like dna. in this method, the biotin-tagged mb-like dna was self-assembled onto a gold electrode to form a stem-loop structure by means of facile gold-thiol chemistry, which resulted in blockage of electronic transmission. it was et off state. in the presence of atp, two nucleotide fragments which were complementary to the lo ... | 2010 | 20299199 |
| nanofluidics in hollow nanowires. | we present a novel scheme for producing nanotube membranes using free-standing hollow nanowires, with easily controllable dimensions. gaas-alinp core-shell nanowires were grown by metal-organic vapor phase epitaxy and were partially embedded in a polymer film. the gaas core and substrate were etched selectively, leaving tubes with open access to both sides of the membrane. electrophoretic transport of t4-phage dna through the hollow nanowires was demonstrated using epifluorescence microscopy. | 2010 | 20299730 |
| effect of intraoperative acetated ringer's solution with 1% glucose on glucose and protein metabolism. | to investigate the effects of the intraoperative administration of ringer's solution with 1% glucose on the metabolism of glucose, lipid and muscle protein during surgery. | 2010 | 20300778 |
| elevated expression of sox9 is related with the progression of gastric carcinoma. | to investigate the sox9 expression and its effects on promoting invasion and metastasis in the primary gastric adenocarcinomas. one hundred and eighty six patients with primary gastric adenocarcinomas who underwent surgery between 2002 and 2006 were classified as low, intermediate, and high sox9 expression groups by immunohistochemistry (ihc). our ihc performance showed that sox9 was lowly expressed in lower crypt of the normal epithelium adjacent to the tumor, and sox9 expression was also obser ... | 2011 | 20301211 |
| [impact of tobacco smoking on biologic background of laryngeal squamous cell carcinoma]. | the most common risk factors related to the occurrence of laryngeal cancer is related to tobacco smoking. it is interlinked to the presence of chemical substance in tobacco smoke. these substances are mutagenic factors and they are carcinogens. these substances penetrate cell, they penetrate cellular nucleus and in consequence, it causes damage to the genetic material. accumulation of mutations enables cells to conduct local invasion, and it initiates tumor invasion and metastasis. we used tissu ... | 2009 | 20301890 |
| laparoscopic rectal surgery: does immediate outcome differ in respect to sex? | this study analyzed the immediate postoperative outcome of the laparoscopic approach to the rectum in relation to the sex of the patient. | 2010 | 20305444 |
| accuracy of endoscopic ultrasound in preoperative staging of esophageal cancer: results from a referral center for early esophageal cancer. | endoscopic ultrasound (eus) has been regarded as the most accurate staging tool in esophageal cancer. staging results have a strong impact on the decision as to whether a patient should undergo endoscopic treatment, surgery alone, or neoadjuvant therapy. this retrospective study was conducted to analyze the accuracy of esophageal cancer staging using eus. | 2010 | 20306385 |
| clinical and histological characteristics of nasopharyngeal cancer in sokoto, north-western, nigeria. | cancer of the nasopharynx poses diagnostic and therapeutic difficulties because of the hidden nature of the nasopharyngeal space, which allows for significant spread of the disease before diagnosis and hence poor prognosis. | 2009 | 20306729 |
| thyroid function in children with growth hormone (gh) deficiency during the initial phase of gh replacement therapy - clinical implications. | abstract: | 2010 | 20307267 |
| cyclobutane pyrimidine dimers are photosensitised by carprofen plus uva in human hacat cells. | every year in the uk about 75,000 cases of non-melanoma skin cancer (nmsc) are registered, and about 9500 people are diagnosed with cutaneous melanoma (cm). the main risk factor for these cancers is exposure to sunlight. the effects of light on skin are wavelength dependent, with wavelengths in the uvb waveband (280-315 nm) being the most carcinogenic. uvb is directly absorbed by dna, producing dimeric pyrimidine photoproducts including cyclobutane pyrimidine dimers (cpd) and pyrimidine (6-4) py ... | 2010 | 20307647 |
| sodium nitroprusside infusion prevents hypothyroidism in patients undergoing coronary artery bypass grafting: a prospective randomized clinical trial. | the level of thyroid hormones is an important factor in determining the outcome of coronary artery bypass patients. sodium nitroprusside (snp) is a natural donor of nitric oxide which has been shown to interfere with thyroid hormone synthesis. whether clinical use of sodium nitroprusside has any effect on thyroid function has not yet been investigated. the aim of this study was to investigate the effects of snp administration on circulating levels of thyroid hormones. | 2010 | 20308916 |
| effects of sub-lethal heroin administration on thyroid stimulating hormone (tsh), thyroid hormones (t3, t4) and thyroid gland of mus norvegicus. | serum tsh level of control mus norvegicus fluctuated between 498.20 +/- 21.92 and 506.80 +/- 22.35 ng ml(-1), thyroxine (t4) between 68.17 +/- 3.46 and 69.03 +/- 4.12 microg dl(-1) and triiodothyronine (t3) between 4.76 +/- 0.52 and 5.00 +/- 0.66 microg dl(-1). sub-lethal heroin administration induced a significant decline in the levels of all the three hormones at 24 hr and 15 days post-administration. decline in the levels of these hormones registered the lowest values (p<0.001) by day 30 of t ... | 2009 | 20329395 |
| subclinical hypothyroidism and autoimmune thyroiditis in pregnancy--a study in south indian subjects. | to analyse the prevalence of subclinical hypothyroidism among pregnant women attending government hospitals in south india. it is also aimed to identify the prevalence of thyroid autoimmunity in euthyroid pregnant women. | 2009 | 20329425 |
| [effectiveness of between--hospital cooperation in staging laparoscopy]. | it is difficult to perform the staging of laparoscopy within the restricted time at a high-volume center. we thus started between-hospital cooperation as of april 2008. in this hospital cooperation, we perform surgery after laparoscopic examination at a cooperating hospital. | 2010 | 20332687 |
| [a case of stage iv afp producing gastric cancer with long-term survival treated by adjuvant chemotherapy with s-1]. | a 66-year-old woman underwent a total gastrectomy for advanced gastric cancer of cardia. the histological diagnosis was moderately-differentiated tubular adenocarcinoma and the pathological stage was iv: t4 (diaphragm), n2, m0. microscopically, there were findings of severe lymphatic and venous invasions with intravenous tumor thrombus around the splenic hilum. immunohistochemical staining confirmed afp production of the tumor. the risk of recurrence was considered very high and her prognosis ve ... | 2010 | 20332696 |
| mobile regulatory cassettes mediate modular shuffling in t4-type phage genomes. | coliphage phi1, which was isolated for phage therapy in the republic of georgia, is closely related to the t-like myovirus rb49. the approximately 275 open reading frames encoded by each phage have an average level of amino acid identity of 95.8%. rb49 lacks 7 phi1 genes while 10 phi1 genes are missing from rb49. most of these unique genes encode functions without known homologs. many of the insertion, deletion, and replacement events that distinguish the two phages are in the hyperplastic regio ... | 2010 | 20333230 |
| prognostic heterogeneity in multilevel n2 non-small cell lung cancer patients: importance of lymphadenopathy and occult intrapulmonary metastases. | to evaluate prognostic heterogeneity that may exist in multilevel n2 non-small lung cancer, we attempted to identify clinicopathologic prognostic factors for multilevel n2 patients who underwent standard surgeries. | 2010 | 20338307 |
| preoperative capecitabine and pelvic radiation in locally advanced rectal cancer--is it equivalent to 5-fu infusion plus leucovorin and radiotherapy? | the aim of this retrospective case-matching study was to compare the treatment outcomes and acute toxicity of preoperative radiotherapy (rt) with capecitabine vs. preoperative rt with intermittent 5-fluorouracil (5-fu) infusion, leucovorin, and mitomycin c in rectal cancer. | 2010 | 20338475 |
| relationship of thyroid function with body mass index and insulin-resistance in euthyroid obese subjects. | it is recognized that overt thyroid dysfunction is associated with weight changes, but the influence of a minor alteration of thyroid function remains unclear. this study aimed to further investigate the relationship between obesity and thyroid function and to examine the possible role of insulin resistance on the hypothalamic-pituitary- thyroid axis. | 2010 | 20339314 |
| isolation, morphologic, serologic and molecular identification of acanthamoeba t4 genotype from the liver of a temminck's tragopan (tragopan temminckii). | members of the genus acanthamoeba are usually free-living amoebae that are found in a variety of ecological niches including soil, fresh and brackish water, dust in the air, heating, ventilating, and air conditioning filters, swimming pools and hot tubs. occasionally they are also known to cause central nervous system infections in humans and animals. we isolated into culture an amoeba from the liver of a temminck's tragopan (horned pheasant) (tragopan temminckii) that died of amoebic infection. ... | 2010 | 20347228 |
| double l-shaped free-style perforator flap for perineal and vaginal reconstruction after cylindrical abdominoperineal resection. | the improvement of patient carcinological status by an abdominoperineal resection by extended posterior perineal approach in a prone position requires the plastic surgeon to consider other reconstructive options. we present an original double l-shaped free-style propeller flap used to reconstruct the vagina and the perineum of a 57-year-old patient after the resection of a t4 tumour of the lower rectum. | 2010 | 20347625 |
| principles and problems of the electrophoretic mobility shift assay. | the electrophoretic mobility shift assay (emsa) is classically used to detect dna binding proteins, the tenet of the emsa is that dna with protein bound, migrates through a polyacrylamide gel more slowly than the corresponding free unbound dna. | 2011 | 20348003 |
| a comparison of the prognostic value of early psa test-based variables following external beam radiotherapy, with or without preceding androgen deprivation: analysis of data from the trog 96.01 randomized trial. | we sought to compare the prognostic value of early prostate-specific antigen (psa) test-based variables for the 802 eligible patients treated in the trans-tasman radiation oncology group 96.01 randomized trial. | 2011 | 20350786 |
| diffusion-weighed mr of the thyroid gland in graves' disease: assessment of disease activity and prediction of outcome. | to assess the activity and clinical course of graves' disease with diffusion-weighted magnetic resonance (mr) imaging. | 2010 | 20350826 |
| inhibitory effect of thyroid blocking antibody (tbab) on the thyroid stimulatory effect of human chorionic gonadotropin (hcg) and equine chorionic gonadotropin (ecg). | we examined the inhibitory effect of thyroid blocking antibody (tbab) on the thyroid stimulating activity of human chorionic gonadotropin (hcg) and equine cg (ecg). five tbab positive sera obtained from patients who had been hypothyroid but were currently on t4 treatment. the tsh binding inhibitory immunoglobulin (tbii) activities of the sera were 60-160 iu/l. inhibition of tsh binding to the tsh receptor (tshr) [tsh binding inhibition (tbi) activity] of hcg or ecg, and inhibition of tbab on hcg ... | 2010 | 20351465 |
| [cloning and expression of lactobaceillus reuteri glycerol dehydratase gene in escherichia coil]. | there is growing interest in biodiesel and this results in the accumulation of glycerol. the exploitation and application of glycerol has attracted more and more attention. in the current study, glycerol was biotransformed to produce 3-hydroxypropionaldehyde by genetic engineering bacteria. it is known that 3-hydroxypopionaldehyde has been widely used as an important intermediate for chemicals, effective antimicrobial agent, and fix agent for tissues. a pair of primers was designed on the basis ... | 2009 | 20352978 |
| treatment results of radiation therapy for muscle-invasive bladder cancer. | to assess local control and survival rates in patients with muscle-invasive bladder cancer treated with external-beam radiotherapy and to investigate prognostic factors. | 2010 | 20354664 |
| the effect of dietary laminaria-derived laminarin and fucoidan on nutrient digestibility, nitrogen utilisation, intestinal microflora and volatile fatty acid concentration in pigs. | in experiment 1, 30 boars were assigned to one of five treatments (n = 6): t1, 0 g kg(-1) seaweed extract (swe); t2, 0.7 g kg(-1) swe; t3, 1.4 g kg(-1) swe; t4, 2.8 g kg(-1) swe and t5, 5.6 g kg(-1) swe. the extract contained laminarin and fucoidan only and was extracted from laminaria spp. in experiment 2, 28 boars were assigned, in a 2 x 2 factorial to one of four treatments (n = 7): t1, control; t2, control plus 300 mg laminarin; t3, control plus 240 mg fucoidan; t4, control plus 300 mg lamin ... | 2010 | 20355064 |
| electrochemical biosensor microarray functionalized by means of biomolecule friendly photolithography. | microfabrication permits the incorporation of dense electrode arrays in microsystems and small volume diagnostic devices. however, the specific functionalization of arbitrary shape electrodes with different biomolecules remains a challenging issue. in the present work, the problem of fabricating closely spaced microelectrodes (20 microm sensor diameter and 20 microm-spaced interdigitated electrodes array) that can be modified selectively in order to create multi-analyte sensor arrays is addresse ... | 2010 | 20356728 |
| histone variant macroh2a1 deletion in mice causes female-specific steatosis. | vertebrate heterochromatin contains a non-allelic variant of the histone h2a called macroh2a1, which has the characteristic of being three times the size of the canonical h2a. the macroh2a1 c-terminal extension can recruit onto chromatin the poly-adp-ribose polymerase (parp)1, which is crucial for dna repair. this led to the speculation that macroh2a1 could be essential for genome surveillance; however, no experimental evidence supported this hypothesis. because macroh2a1 has been found to be en ... | 2010 | 20359320 |
| alternative splicing variant of kallikrein-related peptidase 8 as an independent predictor of unfavorable prognosis in lung cancer. | a relatively unexplored area for biomarker identification is alternative splice variants. we undertook this study to evaluate the usefulness of mrna isoforms encoded by the klk8 (kallikrein-related peptidase 8) gene as prognostic markers for lung cancer. | 2010 | 20360129 |
| improving prediction of lateral node spread in low rectal cancers--multivariate analysis of clinicopathological factors in 1,046 cases. | this study aims to search for independent predictors of lateral node metastasis in low rectal cancers. | 2010 | 20361335 |
| low-temperature t4-like coliphages vb_ecom-vr5, vb_ecom-vr7 and vb_ecom-vr20. | bacteriophages vb_ecom-vr5, vb_ecom-vr7 and vb_ecom-vr20, showing an unusual low-temperature plating profile and producing constantly growing plaques, were isolated from aquatic environments of lithuania. although vb_ecom-vr5, vb_ecom-vr7 and vb_ecom-vr20 resembled phage t4 both in their genome size and in their major structural protein (gp23) pattern, physiological properties of all three phages tested differed significantly from those of t4. with an optimum temperature for plating around 24 de ... | 2010 | 20361343 |