| [immunodiagnostic value and immune protection of the recombinant ts21 antigen of trichinella spiralis]. | to study the immunodiagnostic value and immune protection of the recombinant ts21 protein of trichinella spiralis. | 2009 | 19459493 |
| neuroendocrine function following traumatic brain injury and subsequent intensive care treatment: a prospective longitudinal evaluation. | neuroendocrine dysfunction following traumatic brain injury (tbi) has been described extensively. however, few studies are longitudinal and most lack subtle radiological, clinical, and repetitive endocrine assessment in the acute phase. accordingly, we prospectively assessed neuroendocrine function in 71 patients after tbi. injury was documented by a computed tomography (ct). during the first week, critical clinical data (glasgow coma score, apache score), treatment variables such as duration of ... | 2009 | 19459759 |
| [evaluation of 0.5% hypobaric bupivacaine in spinal anesthesia]. | spinal anesthesia may cause hemodynamic changes due to factors related or not to the patient. the density of the anesthetic compared to the csf, which interferes with the number of dermatomes blocked and, consequently, with the level of the sympathetic blockade and reduction in blood pressure (bp), is one of those factors. the objective of this study was to evaluate the dispersion of 0.5% hypobaric bupivacaine prepared aseptically in a laboratory, with controlled and uniform density. | 2007 | 19462109 |
| [evaluation of serum levels of thyroid hormones in myocardial revascularization.]. | thyroid hormones, thyroxine (t4) and triiodothyronine (t3), regulate anabolism of proteins, lipids, and carbohydrates, and increase oxygen consumption. surgical stress and cardiopulmonary bypass (cpb) can change active hormone levels by interfering with the peripheral conversion and reducing serum levels of t3, without changing the levels of thyrotropin (tsh), which are the characteristics of the euthyroid syndrome. the objective of this work was to compare serum levels of t3, t4 and tsh in pati ... | 2007 | 19462125 |
| what is the role for surgery in patients with stage iii non-small cell lung cancer? | locally advanced non-small cell lung cancer (nsclc) represents a therapeutic challenge. although combined modality has become the standard treatment in stage iii nsclc, the role of surgery in it remains controversial. this review will address recent evidence on the potential role of surgery in either superior sulcus tumors, t4n0-1 tumors with central extension multifocal tumors with nodule(s) in the same lobe, or stage iii disease with mediastinal lymph node involvement. | 2009 | 19465855 |
| plant growth-promoting rhizobacteria allow reduced application rates of chemical fertilizers. | the search for microorganisms that improve soil fertility and enhance plant nutrition has continued to attract attention due to the increasing cost of fertilizers and some of their negative environmental impacts. the objectives of this greenhouse study with tomato were to determine (1) if reduced rates of inorganic fertilizer coupled with microbial inoculants will produce plant growth, yield, and nutrient uptake levels equivalent to those with full rates of the fertilizer and (2) the minimum lev ... | 2009 | 19466478 |
| association between tumor necrosis factor alpha 308g/a polymorphism and increased proinflammatory cytokine release after cardiac surgery with cardiopulmonary bypass in the korean population. | the g-308a polymorphism of the tumor necrosis factor alpha (tnf-alpha) gene has been suggested to be linked to high tnf promoter activity in in vitro studies. however, there have been some controversies in in vivo studies. this study investigated whether a allele at tnf-308 site is associated with (1) the changes in plasma cytokine levels during and after cardiopulmonary bypass (cpb) and (2) an increased incidence of pulmonary morbidity after cpb. | 2009 | 19467887 |
| treatment of locally advanced and metastatic bladder cancer. | there is a significant variation in the treatment strategies adopted for the treatment of locally advanced t3b, t4a, n1-3 and metastatic bladder cancer. there is increasing evidence that we would be able to offer them some benefit in terms of disease-free survival and improving the quality of life. this article is aimed at reviewing the current literature on the treatment strategies in locally advanced and metastatic bladder cancer. | 2008 | 19468366 |
| surgical approach in patients with t4 bladder cancer as primary treatment: disaster or option with improved quality of life. | whereas local control is often insufficient in conservative management of t4 bladder cancer, neoadjuvant chemotherapy delays definite treatment, which could result in increased therapy-associated morbidity and mortality during the course of the disease. primary cystectomy has been reported to be associated with a high complication rate and unsatisfactory clinical efficacy. herein, we report postoperative outcome in 21 t4 bladder cancer patients subjected to primary cystectomy. | 2008 | 19468367 |
| micropapillary component in colorectal carcinoma is associated with lymph node metastasis in t1 and t2 stages and decreased survival time in tnm stages i and ii. | colorectal carcinoma with a micropapillary component (mp) is an exceptionally aggressive variant, but has never been investigated in terms of survival analysis. thirty colorectal carcinomas with a mp were identified from a series of 221 colorectal carcinomas. carcinomas with and without a mp were compared in terms of histologic and immunohistochemical markers. colorectal carcinoma with a mp seemed to have a lower differentiation status, increased tumor budding, more frequent lymphovascular and p ... | 2009 | 19471152 |
| [priming dose of atracurium: measuring orbicularis oculi muscle fade and tracheal intubation conditions.]. | the priming principle consists of administering a low neuromuscular blocker dose, minutes before the total dose for tracheal intubation, to shorten non-depolarizing blockers onset. there is, however, the risk for muscle fade and bronchoaspiration. laryngeal muscles are of especial interest for tracheal intubation maneuvers and airway protection. since their direct monitoring imposes technical difficulties, it has been reported that orbicularis oculi correlates with laryngeal muscles in terms of ... | 2003 | 19471691 |
| [effect of atracurium on pancuronium-induced neuromuscular block recovery.]. | additional neuromuscular blocker doses are in general needed during wall closing after abdominal surgeries. this study aimed at determining during partial pancuronium-induced neuromuscular block recovery, the effect of additional atracurium dose on spontaneous neuromuscular block recovery. | 2004 | 19471739 |
| [thyroid function profile in infants submitted to cardiac surgery with cardiopulmonary bypass.]. | cardiac surgery with cardiopulmonary bypass (cpb) is related to euthyroid disease or hypothalamic-pituitary-thyroid system depression. abnormal hemodynamic status induced by cpb is responsible for several endocrine-metabolic changes, triggering complex systemic inflammatory response. this study aimed at evaluating triiodothyronine (t3), tetraiodothyronine (t4) and thyrotrophin (tsh) behavior in infants submitted to cardiac surgery with cpb. | 2004 | 19471741 |
| [evaluation of residual neuromuscular block and late recurarization in the post-anesthetic care unit.]. | residual postoperative paralysis impairs airway patency increasing the risk for postoperative complications. anti-cholinesterase agents improve neuromuscular transmission by acetylcholine build up in the endplate. however, when there is no longer neostigmine effect, 'recurarization' is theoretically possible since the antagonist agent does not displace neuromuscular blocker from its action site. this study aimed at determining the degree of residual neuromuscular block in the post anesthetic car ... | 2004 | 19471760 |
| [accidental subarachnoid steroid injection during chronic lumbar pain treatment: case report.]. | before epidural steroids were used in chronic lumbar pain, subarachnoid injection of these agents was the treatment of choice. although still preconized by some authors, this technique may lead to severe complications with neurological sequelae. this report aimed at describing a case of accidental subarachnoid injection of steroid associated to local anesthetics during epidural puncture to treat lumbar pain. | 2004 | 19471796 |
| [comparison of recovery time of bolus and continuous infusion mivacurium.]. | mivacurium is a short-acting neuromuscular blocker (nmb), with total duration not exceeding 24 minutes. early publications have reported no significant differences in recovery time, regardless of the route administration. however, clinical experience points out to longer recovery times when the drug is administered in continuous infusion. this study aimed at comparing recovery time of bolus administration and continuous infusion of mivacurium in a group of young adult patients. | 2005 | 19471808 |
| sentinel node biopsy for the individualization of surgical strategy for cure of early-stage colon cancer. | the requirement for nodal analysis currently confounds the oncological propriety of focused purely endoscopic resection for early-stage colon cancer and complicates the evolution of innovative alternatives such as natural orifice transluminal endoscopic surgery (notes) and its hybrids. adjunctive sentinel node biopsy (snb) deserves consideration as a means of addressing this shortfall. | 2009 | 19472012 |
| systolic pulmonary artery pressure and echocardiographic measurements in patients with euthyroid hashimoto's thyroiditis. | the aim of this study was to investigate systolic pulmonary artery pressure (spap) and echocardiographic findings in patients with euthyroid hashimoto's thyroiditis (ht). | 2009 | 19474524 |
| metastasis to the sigmoid or sigmoid mesenteric lymph nodes from rectal cancer. | we analyzed metastases to the sigmoid and sigmoid mesenteric lymph nodes from rectal cancer. | 2009 | 19474698 |
| [spinal anesthesia for cesarean section with 0.5% isobaric bupivacaine plus fentanyl and morphine: prospective study with different volumes]. | spinal block for cesarean section was described few years after the first report of spinal anesthesia by bier in 1899. it was not until the last 5 years that spinal anesthesia has become the most frequent anesthetic method for cesarean section at our hospital. this prospective study aimed at evaluating 0.5% spinal isobaric bupivacaine for cesarean section, injected after fentanyl and morphine, in the lateral position, and at correlating the incidence of hemodynamic changes and cephalad spread wi ... | 2003 | 19475282 |
| effects of clonidine associated to hyperbaric bupivacaine during high-level spinal anesthesia. | published data suggest that clonidine, an alpha2-adrenergic agonist, in association with bupivacaine, may increase the incidence of intraoperative hypotension and bradycardia during high-level spinal anesthesia. this study aimed at determining the synergistic potential of two clonidine doses (45 and 75 microg) and hyperbaric bupivacaine on characteristics and hemodynamic effects of high-level (t4) spinal anesthesia. | 2003 | 19475309 |
| obesity and thyrotropinemia. | to study the relation between body mass index (bmi) and tsh in euthyroid and subclinical hypothyroid obese children and compared serum tsh level among obese and overweight children. | 2009 | 19475347 |
| simultaneous determination of anti-diabetes/anti-obesity drugs by lc/pda, and targeted analysis of sibutramine analog in dietary supplements by lc/ms/ms. | the safety of dietary supplements is questionable as there have been occasional reports of products contaminated with illegal adulterants. the present study was carried out to develop trustworthy methodologies to screen for six anti-diabetic drugs (phenformin, rosiglitazone, glipizide, glimepiride, glybenclamide and gliclazide) and six anti-obesity drugs (ephedrine, fenfluramine, t3, t4, fluoxetine and sibutramine) in dietary supplements. a simultaneous determination method of the 12 drugs by li ... | 2009 | 19475544 |
| appropriate selection of patients for combined organ resection in cases of gastric carcinoma invading adjacent organs. | proper patient selection for multi-organ resection in t4 gastric carcinoma remains controversial. our aim was to investigate which patients might benefit from multi-organ resection. | 2009 | 19475581 |
| association of kyphosis and spinal skeletal abnormalities with intrathoracic stomach: a link toward understanding its pathogenesis. | modern-day concepts about the pathogenesis of an intrathoracic stomach include crural diaphragm muscular deterioration, loss of phrenoesophageal ligament integrity, and presence of abdominothoracic pressure gradients. the role of spinal abnormalities has received little attention. based on clinical observation, we hypothesized that kyphosis and other spinal diseases are components of the pathophysiology of an intrathoracic stomach. | 2009 | 19476791 |
| adjuvant chemoradiation therapy for pancreatic adenocarcinoma: who really benefits? | the role of adjuvant chemoradiation therapy (crt) in pancreatic cancer remains controversial. the primary aim of this study was to determine if crt improved survival in patients with resected pancreatic cancer in a large, multiinstitutional cohort of patients. | 2009 | 19476845 |
| epidural spinal cord compression with neurologic deficit associated with intrapedicular application of hemostatic gelatin matrix during pedicle screw insertion. | case report. | 2009 | 19478651 |
| the cortical topography of visual evoked potentials elicited by chromatic and luminance motion. | when motion-onset veps are elicited by moving luminance patterns, the motion specific component of the response, n2, is more prominent at electrode sites that overlay the lateral occipito-parietal cortex close to area v5/mt, than over the primary visual cortex. functional segregation suggests that colour and motion processing should take place along different ventral occipito-temporal and lateral occipito-parietal pathways, respectively. hence, a different topographical distribution might be exp ... | 2007 | 19478864 |
| competitive inhibition of thyroidal uptake of dietary iodide by perchlorate does not describe perturbations in rat serum total t4 and tsh. | perchlorate (clo4(-)) is an environmental contaminant known to disrupt the thyroid axis of many terrestrial and aquatic species. clo4(-) competitively inhibits iodide uptake into the thyroid at the sodium/iodide symporter and disrupts hypothalamic-pituitary-thyroid (hpt) axis homeostasis in rodents. | 2009 | 19479014 |
| [spinal anesthesia for outpatient pediatric surgery in 1 - 5 years old children with 0.5% isobaric enantiomeric mixture of bupivacaine (s75-r25)]. | commercially available bupivacaine is a racemic mixture of s(-) and r(+) enantiomers. although the s(-) bupivacaine enantiomer is less toxic than r(+) bupivacaine to cardiovascular and central nervous systems, its relative efficacy has not yet been determined in spinal anesthesia for pediatric surgery. the aim of this study was to evaluate the effects of spinal anesthesia with a 0.5% isobaric mixture of s(-) bupivacaine(75%) + r(+) bupivacaine(25%) in 40 children aged 1 to 5 years scheduled for ... | 2002 | 19479091 |
| [cisatracurium pharmacodynamics in renal transplantation]. | cisatracurium seems to be beneficial, especially for patients with organ dysfunction, due to organ-independent hofmann elimination and a lower trend to histamine release. this study aimed at determining cisatracurium pharmacodynamic profile in renal transplantation. | 2002 | 19479092 |
| [isobaric 0.5% bupivacaine for spinal anesthesia in pediatric outpatient surgery of 6 to 12 year old children: a prospective study.]. | spinal anesthesia produces deep intra-operative analgesia in children and, when combined with general anesthesia, decreases perioperative anesthetics and opioids requirements. this prospective study aimed at evaluating clinical characteristics of spinal anesthesia with 0.5% racemic bupivacaine in 40 children, aged 6 to 12 years. | 2002 | 19479104 |
| the relationship between smoking machine derived tar yields and biomarkers of exposure in adult cigarette smokers in the us. | comprehensive data on human exposure to smoke constituents from different machine-measured tar yield cigarettes is limited. methods: this study used a stratified, cross-sectional, multi-center design to estimate biomarkers of exposure (boe) from nicotine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (nnk), pyrene, co, acrolein, and 1,3-butadiene and their relationship to tar yield categories of cigarette in adult smokers in the u.s. 3625 adults smokers were enrolled into four tar categories < ... | 2009 | 19481578 |
| angiofollicular lymph node hyperplasia resembling a spinal nerve sheath tumor: a rare case of castleman's disease. | angiofollicular lymph node hyperplasia (castleman's disease) is a lymphoproliferative disorder of unknown etiology. although uncommon, the localized form of this disease can manifest in the central nervous system, typically as a meningeal-based intracranial lesion. castleman's disease involving the spine is exceedingly rare. this represents only the second reported case of a patient with castleman's disease whose presentation mimicked that of a spinal nerve sheath tumor. | 2009 | 19482516 |
| recombinant human granulocyte-macrophage colony-stimulating factor (gm-csf, sargramostim) administered for 3 years as adjuvant therapy of stages ii(t4), iii, and iv melanoma. | a hypothesis generating study was conducted to evaluate the safety and efficacy of prolonged (3 y) administration of granulocyte-macrophage colony-stimulating factor (gm-csf, sargramostim) as surgical adjuvant therapy in patients with melanoma at high risk of recurrence. ninety-eight evaluable patients with stages ii(t4), iii, or iv melanoma were given prolonged treatment with gm-csf after surgical resection of disease. the gm-csf was administered subcutaneously in 28-day cycles, such that a dos ... | 2009 | 19483646 |
| report of an hiv and hhv-8 negative case of primary effusion lymphoma with idiopathic t4 lymphocytopenia. | although primary effusion lymphoma (pel) is usually associated with human herpes virus-8/kaposi sarcoma herpes virus (hhv-8/kshv) and human immunodeficiency virus (hiv), there are several reports of hhv-8/kshv and hiv negative cases, mainly in the setting of immunodeficiency. here, we report the second case of pel associated with idiopathic t4 lymphocytopenia (icl), which was hhv-8/kshv negative, hiv negative and epstein-barr virus positive, while no other causative agents for immunodeficiency w ... | 2009 | 19484335 |
| thyroid function and autoantibody status among women who spontaneously deliver under 35 weeks of gestation. | recent studies report an association between maternal thyroid auto-antibodies and preterm birth. none have made the important distinction between spontaneous and iatrogenic preterm birth. we investigated the association between spontaneous preterm birth before 35-week gestation and both thyroid function and auto-antibody status. | 2009 | 19486018 |
| a 7-year experience with low blood tsh cutoff levels for neonatal screening reveals an unsuspected frequency of congenital hypothyroidism (ch). | the guidelines of the national academy of clinical biochemistry advocated the use of low bloodspot tsh (b-tsh) threshold for newborn screening of congenital hypothyroidism (ch). the impact generated by the application of this indication is largely unknown. | 2009 | 19486019 |
| mage-a antigens in patients with primary oral squamous cell carcinoma. | mage-a antigens are only expressed on tumor cells. the aim of this study was to identify their expression in patients with oral squamous cell carcinoma (oscc). forty-seven patients with primary oscc was selected retrospectively. histo-pathological sections were stained immunohistochemically with mage-a antibody 57b. the results were evaluated regarding tumor size (t), lymph-node metastasis (n), blood vessel infiltration (v), lymph vessel infiltration (l), grading (g), and sex. mage-a antigens we ... | 2010 | 19488795 |
| thyroxine alone or thyroxine plus triiodothyronine replacement therapy for hypothyroidism. | standard therapy for patients with hypothyroidism is replacement with synthetic thyroxine (t4). however, thyroxine plus triiodothyronine (t3) replacement therapy resulted in marked improvements in several items of the profile of mood states and in a few indices of psychometric function and quality of life. the adequacy of thyroxine alone versus thyroxine plus triiodothyronine to treat hypothyroidism has yielded conflicting results. therefore, we conducted a systematic review of all included publ ... | 2009 | 19491714 |
| probing protein folding using site-specifically encoded unnatural amino acids as fret donors with tryptophan. | the experimental study of protein folding is enhanced by the use of nonintrusive probes that are sensitive to local conformational changes in the protein structure. here, we report the selection of an aminoacyl-trna synthetase/trna pair for the cotranslational, site-specific incorporation of two unnatural amino acids that can function as fluorescence resonance energy transfer (fret) donors with trp to probe the disruption of the hydrophobic core upon protein unfolding. l-4-cyanophenylalanine (pc ... | 2009 | 19492814 |
| three-dimensional reconstruction of biological macromolecular complexes from in-lens scanning electron micrographs. | two helical samples: f-actin and the bacteriophage t4 tail sheath were reconstructed in three dimensions from contrast enhanced (rotational shadowing and negatively stained) in-lens cryo-field emission scanning electron micrographs, using the iterative real-space helical reconstruction method. the f-actin--and bacteriophage t4 reconstructions compare favourably to an atomic model refined against fibre diffraction data and a cryo-electron microscopy reconstruction, respectively. these results sho ... | 2009 | 19493107 |
| relationship between the expression of toll-like receptor 2 and 4 in mononuclear cells and postoperative acute lung injury in orthotopic liver transplantation. | the aim of this study was to investigate the potential relationship between the dynamic expression of toll-like receptor 2 and 4 (tlr2/4) in peripheral blood mononuclear cells as well as changes in serum concentration of inflammatory factors and acute lung injury (ali) in patients after orthotopic liver transplantation (olt). | 2009 | 19493410 |
| provisional clinical chemistry parameters in the african sharptooth catfish (clarias gariepinus). | pollution affects aquatic systems worldwide and there is an urgent need for efficient monitoring. fish are generally sensitive to their environment and are thus considered to be valuable bioindicator species. the african sharptooth catfish (clarias gariepinus) is particularly important in this respect because of its very wide distribution. in order to use c. gariepinus as a bioindicator species its baseline clinical chemistry must be defined. existing data are scarce, and the objective of this w ... | 2008 | 19496313 |
| [an operative case of ulcerative colitis associated with hyperthyroidism]. | we encountered a rare operative case of hyperthyroidism followed by ulcerative colitis (uc). a 26-year-old mam was referred to our department to undergo an operation. we suspected the possible complication of adrenal insufficiency, since he suffered from severe weight loss, a high fever and palpitation on admission. we diagnosed hyperthyroidism, however, based on the presence of high serum free t3 and t4 levels and a decreased tsh level. after improving the symptoms and the thyroid function by a ... | 2009 | 19498314 |
| visfatin plasma concentrations in patients with hyperthyroidism and hypothyroidism before and after control of thyroid function. | alterations in thyroid function are associated with changes in body weight, metabolism, and low-grade inflammation. in several studies, plasma levels of visfatin were found to be associated with body mass index, diabetes, and metabolic syndrome. in our study we aimed to evaluate visfatin levels according to thyroid dysfunction. the study cohort comprised 56 hashimoto thyroiditis patients with hypothyroidism (43.94+/-14.27 yr), 56 graves patients with hyperthyroidism (45.87+/-13.28 yr), and 56 eu ... | 2009 | 19498324 |
| renal cell carcinoma. 2002 tnm classification is still adequate? | the tnm classification should be a tool that allows the physician to make therapeutic decisions and gain even a prognostic scheme. currently, the 2002 tnm classification for kidney cancer doesn't have these features. really it doesn't make a distinction when performed a conservative therapy in the early stages: literature and the clinical experience suggest that the criteria for a partial resection of the kidney is the location of the tumour, rather than its size; for this reason, the division p ... | 2009 | 19499760 |
| controlling the morphology in dna condensation and precipitation. | this work addresses the influence of solution inhomogeneity on conformation, aggregation, and coil/globule and bundle/single chain coexistence of t4 dna molecules. the inhomogeneity is induced by mixing two solutions containing, respectively, protamine and dna, with different relative concentrations, but aiming at producing the same final concentrations. the study was conducted by means of fluorescence microscopy (fm), complemented with scanning electron microscopy (sem). it is shown that the de ... | 2009 | 19499951 |
| outbreak of betanodavirus infection in tilapia, oreochromis niloticus (l.), in fresh water. | a betanodavirus associated with a massive mortality was isolated from larvae of tilapia, oreochromis niloticus, maintained in fresh water at 30 degrees c. histopathology revealed vacuolation of the nervous system, suggesting an infection by a betanodavirus. the virus was identified by indirect fluorescent antibody test in the ssn1 cell line and further characterized by sequencing of a pcr product. sequencing of the t4 region of the coat protein gene indicated a phylogenetic clustering of this is ... | 2009 | 19500206 |
| tsh-lowering effect of metformin in type 2 diabetic patients: differences between euthyroid, untreated hypothyroid, and euthyroid on l-t4 therapy patients. | to assess the interplay between metformin treatment and thyroid function in type 2 diabetic patients. | 2009 | 19502536 |
| construction of an energy transfer system in the bio-nanocup space by heteromeric assembly of gp27 and gp5 proteins isolated from bacteriophage t4. | protein assemblies, such as viruses and ferritins, have been employed as useful molecular templates for the accumulation of organic and inorganic compounds to construct bio-nanomaterials. while several methods for conjugation of heterofunctional molecules with protein assemblies have been reported, it remains difficult to control their fixation sites in the assemblies. in this article, we demonstrate the three-dimensional arrangement of different types of fluorescent probes using the heteromeric ... | 2009 | 19503942 |
| preoperative t staging of gastric carcinoma obtained by mdct vessel probe reconstructions and correlations with histological findings. | this study aims to evaluate the diagnostic accuracy of 16-row multidetector ct (mdct) and vessel probe reconstructions in the t staging of gastric carcinoma. fifty-three patients (39 men, 14 women, mean age 57.5) with an endoscopic diagnosis of gastric adenocarcinoma underwent ct examination. a hypotonic drug was administered, and the gastric walls were distended by the ingestion of 400-600 ml of water. a biphasic technique with 40-s and 70-s delay was used after endovenous contrast material inj ... | 2010 | 19504100 |
| chemoselection as a strategy for organ preservation in patients with t4 laryngeal squamous cell carcinoma with cartilage invasion. | high rates of overall survival (os) and laryngeal preservation were achieved in two sequential phase ii clinical trials in patients with stage iii/iv laryngeal squamous cell carcinoma (scc). patients were treated with chemoradiation after a >50% primary tumor response to one cycle of neoadjuvant chemotherapy (ic). we analyzed outcomes for t4 patients with cartilage invasion from both studies. | 2009 | 19504552 |
| synthesis of semitelechelic maleimide poly(pega) for protein conjugation by raft polymerization. | maleimide end functionalized polymers for site-selective conjugation to free cysteines of proteins were synthesized using reversible addition-fragmentation chain transfer (raft) polymerization. a furan-protected maleimide chain transfer agent (cta) was employed in the raft polymerization of poly(ethylene glycol) methyl ether acrylate (pega). gel permeation chromatography (gpc) with laser light scattering detection indicated that 20,000 and 39,000 da polypega had been made with polydispersity ind ... | 2009 | 19505142 |
| thyroid hormone levels associated with active and passive cigarette smoking. | active and passive cigarette smoking are a risk factor among women of reproductive age-leading to reproductive health morbidity, including fetal and infant death and developmental problems with the newborn. however, the underlying physiological mechanisms for these ill-effects are not fully understood. smoke exposure may affect various metabolic and biological processes, including hormone biosynthesis and secretion, interfere with thyroid hormone release, binding, transport, storage, and clearan ... | 2009 | 19505184 |
| molecular components underlying nongenomic thyroid hormone signaling in embryonic zebrafish neurons. | neurodevelopment requires thyroid hormone, yet the mechanisms and targets of thyroid hormone action during embryonic stages remain ill-defined. we previously showed that the thyroid hormone thyroxine (t4) rapidly increases voltage-gated sodium current in zebrafish rohon-beard cells (rbs), a primary sensory neuron subtype present during embryonic development. here, we determined essential components of the rapid t4 signaling pathway by identifying the involved intracellular messengers, the target ... | 2009 | 19505305 |
| genotyping of trim5 locus in northern pig-tailed macaques (macaca leonina), a primate species susceptible to human immunodeficiency virus type 1 infection. | the pig-tailed macaques are the only old world monkeys known to be susceptible to human immunodeficiency virus type 1 (hiv-1) infection. we have previously reported that the trim5-cyclophilin a (trimcyp) fusion in pig-tailed macaques (macaca nemestrina) is dysfunctional in restricting hiv-1, which may explain why pig-tailed macaques are susceptible to hiv-1 infection. similar results have also been reported by other groups. however, according to the current primate taxonomy, the previously repor ... | 2009 | 19505341 |
| longitudinal evaluation of patients with a homozygous r450h mutation of the tsh receptor gene. | the r450h mutation of the tsh receptor (tshr) gene has been frequently observed in japanese patients with resistance to tsh. the purpose of this study was to clarify the phenotype of patients with a homozygous r450h mutation of the tshr gene; the mutant receptor has previously demonstrated moderately impaired function in vitro. | 2009 | 19506388 |
| treatment outcomes of t4 locally advanced head and neck cancers with soft tissue invasion or bone and cartilage invasion. | purpose/objective(s):: t4 locally advanced squamous cell cancers of the head and neck (scchn) with bone and cartilage invasion (bci) traditionally have been treated with resection followed up with chemoradiotherapy (crt). because the organ preservation trials, more patients with bci, as well as those with soft tissue invasion (sti), have been treated with definitive crt. this is a review of our experience. materials/methods:: we performed a retrospective review of patients who underwent definiti ... | 2009 | 19506456 |
| vertebral fracture assessment: impact of instrument and reader. | many osteoporotic vertebral fractures are not clinically recognized but increase fracture risk. we hypothesized that a newer generation densitometer increases the number of evaluable vertebrae and vertebral fractures detected. we also explored the impact of reader experience on vertebral fracture assessment (vfa) interpretation. | 2010 | 19506794 |
| comparative genomics of marine cyanomyoviruses reveals the widespread occurrence of synechococcus host genes localized to a hyperplastic region: implications for mechanisms of cyanophage evolution. | the vast majority of cyanophages isolated to date are cyanomyoviruses, a group related to bacteriophage t4. comparative genome analysis of five cyanomyoviruses, including a newly sequenced cyanophage s-rsm4, revealed a 'core genome' of 64 genes, the majority of which are also found in other t4-like phages. subsequent comparative genomic hybridization analysis using a pilot microarray showed that a number of 'host' genes are widespread in cyanomyovirus isolates. furthermore, a hyperplastic region ... | 2009 | 19508343 |
| benchmarking circumferential resection margin (r1) resection rate for rectal cancer in the neoadjuvant era. | circumferential resection margin (crm) involvement (r1) is used to audit rectal cancer surgical quality. however, when downsizing chemoradiation (dcrt) is used, crm audits both dcrt and surgery, its use reflecting a high casemix of locally advanced tumours. we aimed to evaluate predictors of r1 and benchmark r1 rates in the dcrt era, and to assess the influence of failure of steps in the multidisciplinary team (mdt) process to crm involvement. | 2010 | 19508531 |
| dose-dependent acute effects of recombinant human tsh (rhtsh) on thyroid size and function: comparison of 0.1, 0.3 and 0.9 mg of rhtsh. | recombinant human tsh (rhtsh) is used to augment the effect of radioiodine therapy for nontoxic multinodular goitre. reports of acute thyroid swelling and hyperthyroidism warrant safety studies evaluating whether these side-effects are dose dependent. | 2010 | 19508679 |
| genotypic identification of acanthamoeba sp. isolates associated with an outbreak of acanthamoeba keratitis. | to determine whether increased rates of acanthamoeba keratitis (ak) are due to changes in municipal water treatment or to emergence of a more pathogenic strain of acanthamoeba. | 2009 | 19512903 |
| pure sensory deficit at the t4 sensory level as an isolated manifestation of lateral medullary infarction. | in rare cases restricted sensory deficits along the somatotopic topography of the spinothalamic tract can develop from a lateral medullary infarction. to our knowledge, isolated dermatomal sensory deficit as a single manifestation of a lateral medullary infarction has not been reported previously. a 58-year-old man presenting with sudden left-sided paresthesia complained of sensory deficit of pain and temperature below the left t4 sensory level without other neurologic deficits. diffuse- and t2- ... | 2007 | 19513303 |
| [the role of thyroid hypofunction in development of metabolic syndrome]. | to study the role of hypothyroidism and concomitant obesity in the development of metabolic syndrome (ms). | 2009 | 19514426 |
| dorsal spinal cord stimulation obtunds the capacity of intrathoracic extracardiac neurons to transduce myocardial ischemia. | populations of intrathoracic extracardiac neurons transduce myocardial ischemia, thereby contributing to sympathetic control of regional cardiac indices during such pathology. our objective was to determine whether electrical neuromodulation using spinal cord stimulation (scs) modulates such local reflex control. in 10 anesthetized canines, middle cervical ganglion neurons were identified that transduce the ventricular milieu. their capacity to transduce a global (rapid ventricular pacing) vs. r ... | 2009 | 19515981 |
| nonadditivity in the recognition of single-stranded dna by the schizosaccharomyces pombe protection of telomeres 1 dna-binding domain, pot1-dbd. | the schizosaccharomyces pombe protection of telomeres 1 (sppot1) protein recognizes the 3' single-stranded ends of telomeres and provides essential protective and regulatory functions. the ssdna-binding activity of sppot1 is conferred by its ssdna-binding domain, pot1-dbd (residues 1-389), which can be further separated into two distinct domains, pot1pn (residues 1-187) and pot1pc (residues 188-389). here we show that pot1pc, like pot1pn, can function independently of pot1-dbd and binds specific ... | 2009 | 19518131 |
| the structure of gene product 6 of bacteriophage t4, the hinge-pin of the baseplate. | the baseplate of bacteriophage t4 is a multicomponent protein complex, which controls phage attachment to the host. it assembles from six wedges and a central hub. during infection the baseplate undergoes a large conformational change from a dome-shaped to a flat, star-shaped structure. we report the crystal structure of the c-terminal half of gene product (gp) 6 and investigate its motion with respect to the other proteins during the baseplate rearrangement. six gp6 dimers interdigitate, formin ... | 2009 | 19523898 |
| [locally advanced (neglected) breast cancer: the reality? relevance of two cases and reflection how to optimise the multidisciplinary approach]. | the standard treatment for breast cancer patients with untreated locally advanced breast cancer is neo-adjuvant chemotherapy or hormonal treatment. in some cases, this treatment is followed by surgery and/or radiotherapy when the multidisciplinary approach is present. in some cases of patients presenting metastatic diseases, the radiotherapy is forgotten or proposed late when the local disease is extremely advanced with symptoms and decreased quality of life. two cases of extremely advanced non ... | 2009 | 19524471 |
| thyroid hormones and personality traits in attempted suicide. | the research on thyroid hormones and personality traits is quite sparse and mainly focused on male forensic psychiatric populations in which the relationship between thyroid hormones and psychopathy and aggression-related personality traits has been reported. the suicidal temperament hypothesis suggests that certain personality traits such as aggression, anxiety proneness, impulsivity, and low socialization may render an individual vulnerable to the risk of suicide. the aim of this study was to ... | 2009 | 19525070 |
| preoperative radiochemotherapy in the treatment of advanced oral cancer: outcome of 276 patients. | the aim of this study was to review survival and locoregional control in patients with advanced oral and oropharyngeal squamous cell carcinoma treated by multimodal therapy with preoperative radiochemotherapy and radical surgery. | 2009 | 19525119 |
| prospective phase ii study of neoadjuvant doxorubicin followed by cisplatin/docetaxel in locally advanced breast cancer. | the objective of this study is to evaluate the efficacy and safety profile of the doxorubicin followed by cisplatin/docetaxel as primary chemotherapy for patients with locally advanced breast cancer (labc). for this evaluation, 59 patients with labc (t2-t4, n0-n2, m0) received three cycles of doxorubicin, followed by three cycles of cisplatin/docetaxel and followed by definitive surgery and locoregional radiotherapy with or without tamoxifen. the primary end point was pathologic complete respons ... | 2010 | 19526202 |
| evaluation of thoracic pedicle screw placement in adolescent idiopathic scoliosis. | pedicle screw fixation is a challenging procedure in thoracic spine, as inadvertently misplaced screws have high risk of complications. the accuracy of pedicle screws is typically defined as the screws axis being fully contained within the cortices of the pedicle. one hundred and eighty-five thoracic pedicle screws in 19 patients that were drawn from a total of 1.797 screws in 148 scoliosis patients being suspicious of medial and lateral malpositioning were investigated, retrospectively. screw c ... | 2009 | 19526376 |
| [impact of shengmal injection on changes of immunological function in patients after cardiopulmonary bypass]. | to study the impact and mechanism of shengmai injection (smi) on the immunological function changes after cardiopulmonary bypass. | 2009 | 19526756 |
| cdna display: a novel screening method for functional disulfide-rich peptides by solid-phase synthesis and stabilization of mrna-protein fusions. | we report a robust display technology for the screening of disulfide-rich peptides, based on cdna-protein fusions, by developing a novel and versatile puromycin-linker dna. this linker comprises four major portions: a 'ligation site' for t4 rna ligase, a 'biotin site' for solid-phase handling, a 'reverse transcription primer site' for the efficient and rapid conversion from an unstable mrna-protein fusion (mrna display) to a stable mrna/cdna-protein fusion (cdna display) whose cdna is covalently ... | 2009 | 19528071 |
| antitumor effect of combined treatment of mice with cytostatic agents and bacteriophage t4. | the past few years have shown significant resurgent interest in the old concept of bacteriophage therapy. some research groups continue to develop whole bacteriophage preparations as alternatives to antibiotic antibacterial treatment. however, improvements in the methods of purification of phage preparations open new opportunities in the successful treatment of antibiotic-resistant bacterial infections. an open question remains on whether bacteriophage preparations (bp) can be safely applied in ... | 2009 | 19528503 |
| responses of hematological parameters and aerobic performance of elite men and women swimmers during a 14-week training program. | the main purpose of the present investigation was to verify the responses of hematological parameters in men and women competitive swimmers during a 14-week training program. twenty-three olympic and international athletes were evaluated 4 times during the experiment: at the beginning of the endurance training phase (t1), at the end of the endurance training phase (t2), at the end of the quality phases (t3), and at the end of the taper period (t4). on the first day at 8:00 am, each swimmer had a ... | 2009 | 19528852 |
| effects of thyroxine replacement on serum creatinine and cystatin c in patients with primary and central hypothyroidism. | serum cystatin c (cysc) is a marker for kidney function, possibly superior to serum creatinine (cr). cr is increased and cysc decreased in primary hypothyroidism; these changes are reversed upon thyroxine (t4) replacement therapy. this (pilot) study was performed to see whether these opposing changes of cysc and cr could be confirmed in patients with central hypothyroidism. | 2009 | 19529992 |
| value of multidetector-row computed tomography in the preoperative t and n staging of gastric carcinoma: a large-scale chinese study. | to investigate the value of multidetector-row computed tomography (mdct) in the preoperative t and n staging of gastric carcinoma and to further investigate the clinicopathological factors affecting the diagnostic accuracy. | 2009 | 19530124 |
| polychlorinated biphenyls affect thyroid function and induce autoimmunity in sprague-dawley rats. | polychlorinated biphenyls (pcbs) have been reported to cause a variety of toxic effects. in order to assess the thyroid function after exposure to pcbs and investigate whether pcbs induce autoimmune process in the thyroid gland, we determined the levels of serum thyroid hormones (ft3, ft4, and t4), thyroid-stimulating hormone (tsh), and thyroid peroxidase antibody (tpoab) in sprague-dawley rats treated with a commercial mixture of pcbs, aroclor 1,254 (pcbs group), or the antithyroid drug, propyl ... | 2009 | 19530273 |
| [gonadal and thyroid function after treatment for hodgkin's lymphoma in adolescents]. | complete treatment for hodgkin's lymphoma (hl) may disturb functioning of different organs leading to deteriorated quality of future life. endocrine complications are one of the most common and may be the result of radiotherapy of neck, mediastinal and infradiaphragmatic regions, as well as chemotherapy, especially with alkylating agents. the aim of our study was to analyse gonadal and thyroid disturbances in young adults after the treatment for hl in childhood. | 2008 | 19531819 |
| demographical aspects of schmorl nodes: a skeletal study. | a descriptive study of the association between schmorl nodes (sns) and gender, ethnic origin, and age in a normal skeletal population. | 2009 | 19531985 |
| expression of hepatocyte growth factor and basic fibroblast growth factor as prognostic indicators in gastric cancer. | we have investigated the correlations among hepatocyte growth factor (hgf) mrna expression, basic fibroblast growth factor (bfgf) mrna expression, tumor microvessel density (mvd), and clinical pathological features of gastric cancer in chinese patients. in situ hybridization was used to detect the expression of hgf and bfgf mrnas, and immunohistochemistry was used to detect cd34 in 105 gastric cancer tissues and in 20 normal control tissues. the rate of hgf mrna expression in normal gastric tiss ... | 2009 | 19533745 |
| three new types of interpenetrating sphere packings. | three new types of homogeneous interpenetrating sphere packings are described. in the general position of space group ccce, two sphere packings of type 3/10/o1 can be combined to form interpenetrating sphere packings of type o[3/10/o1]2. the other two types of interpenetrating sphere packings show symmetry fddd: two packings of type 3/10/t4 are intertwined in o[3/10/t4]2 and three packings of type 3/4/t1 in o[3/4/t1]3. | 2009 | 19535855 |
| late esophageal toxicity after radiation therapy for head and neck cancer. | the aim of this study was to determine the incidence of esophageal toxicity after radiation therapy for head and neck cancer. | 2010 | 19536858 |
| [effects of ulinastatin on coagulation and platelet function in patients undergoing coronary artery bypass grafting with cardiopulmonary bypass]. | to investigate the effects of ulinastatin (u) on coagulation, platelet function, and postoperative bleeding in patients undergoing coronary artery bypass grafting (cabg) with cardiopulmonary bypass (cpb). | 2009 | 19537033 |
| [the biotin-thyroxin conjugate as a bifunctional ligand of binding proteins]. | the conjugate of the residue of vitamin h (biotin, bt) with the hormone of thyroid gland thyroxin (t4) was prepared by n-acylation of n-(3-aminopropyl) biotin amide with n-hydroxysuccinimide ester of n-acetyl thyroxin. the interactions of the bt-t4 conjugate with one or simultaneously with two binding proteins with affinity to bt or t4 in solution and on a solid phase were studied by electron spectroscopy, enzyme immunoassay, and computer modeling. bt-t4 was specifically fixed in the bt-binding ... | 2009 | 19537169 |
| caste and sex specific olfactory glomerular organization and brain architecture in two sympatric ant species camponotus sericeus and camponotus compressus (fabricius, 1798). | we use monoclonal antibodies against synaptic proteins and anterograde tracing with neurobiotin to describe the architecture of the antennal lobes in different castes of two ant species -camponotus sericeus and camponotus compressus. the reproductives and worker classes are readily categorized based on size and external morphology. the overall organization of brain neuropile is comparable between castes with differences only in the visual ganglia. males have a larger fraction of neuropile occupi ... | 2009 | 19539048 |
| modification of isoflavones in soybean seeds via expression of multiple phenolic biosynthetic genes. | to modify the level and composition of isoflavones, the important bioactive constituents of soybean seeds, soybean was transformed via co-bombardment of embryogenic cultures with three dna cassettes containing the chs6-chalcone synthase and ifs2-isoflavone synthase genes, and a fragment of pal5-phenylalanine ammonia-lyase gene, all in sense orientation under the lectin promoter mixed with the selectable marker gene, hpt (hygromycin phosphotransferase) under the 35s promoter. four of six fertile ... | 2009 | 19539487 |
| outcome after conservative surgery and breast irradiation in 5,717 patients with breast cancer: implications for supraclavicular nodal irradiation. | to evaluate the outcome and predictive factors of patients who underwent breast-conserving surgery and adjuvant radiotherapy to the whole breast only, without supraclavicular nodal irradiation. | 2010 | 19540052 |
| total androgen blockade versus a luteinizing hormone-releasing hormone agonist alone in men with high-risk prostate cancer treated with radiotherapy. | to assess whether short-course total androgen blockade vs. a luteinizing hormone-releasing hormone (lhrh) agonist alone affects the risk of prostate cancer-specific mortality (pcsm) in men with localized but high-risk disease treated with radiotherapy. | 2010 | 19540066 |
| intensity-modulated radiotherapy in the treatment of oropharyngeal cancer: clinical outcomes and patterns of failure. | to report outcomes, failures, and toxicities in patients treated with intensity-modulated radiotherapy (imrt) for squamous cell carcinoma of the oropharynx. | 2010 | 19540068 |
| lower- and higher-grade subtypes of diffuse gastric cancer. | diffuse gastric cancer, characterized by poorly cohesive, diffusely infiltrating cells with no or little gland formation, is known to show several morphologic variants, but their prognostic value, if any, is poorly documented. in this article, 119 cases of invasive (t1b to t4) diffuse gastric cancer, which had undergone potentially curative surgery and were followed postoperatively for a median time of more than 10 years, were investigated for histologic or histochemical patterns possibly predic ... | 2009 | 19540560 |
| portal control of viral prohead expansion and dna packaging. | bacteriophage t4 terminase packages dna in vitro into empty small or large proheads (esps or elps). in vivo maturation of esps yields the more stable and voluminous elps required to contain the 170 kb t4 genome. functional proheads can be assembled containing portal-gfp fusion proteins. in the absence of terminase activity these accumulated in esps in vivo, whereas wild-type portals were found in elps. by nuclease protection assay dsdnas of lengths 0.1, 0.2, 0.5, 5, 11, 20, 40 or 170 kb were eff ... | 2009 | 19541336 |
| an icosahedral algal virus has a complex unique vertex decorated by a spike. | paramecium bursaria chlorella virus-1 is an icosahedrally shaped, 1,900-a-diameter virus that infects unicellular eukaryotic green algae. a 5-fold symmetric, 3d reconstruction using cryoelectron microscopy images has now shown that the quasiicosahedral virus has a unique vertex, with a pocket on the inside and a spike structure on the outside of the capsid. the pocket might contain enzymes for use in the initial stages of infection. the unique vertex consists of virally coded proteins, some of w ... | 2009 | 19541619 |
| [correlation between symptoms and survival in patients with renal cell carcinoma]. | to evaluate the correlation between type of presentation in patients with renal cell carcinoma and survival. | 2009 | 19542592 |
| [a case of advanced ampullary carcinoma successfully resected after primary chemotherapy with s-1 and gemcitabine]. | the patient was a 53-year-old male who was admitted on an emergency basis with obstructive jaundice. he was diagnosed as having advanced ampullary carcinoma(t4 n0 h1, stage iv b). to reduce the degree of obstructive jaundice, a self-expandable metallic stent was placed in the area of the biliary obstruction. immediately after relief from obstructive jaundice, combination chemotherapy of s-1 and gemcitabine was given. subsequently, ca19-9, the tumormarker level was reduced, the metastatic liver t ... | 2009 | 19542724 |
| thyrotropin variations may explain some positive radioiodine therapy scans in patients with negative diagnostic scans. | thyroglobulin (tg) is a specific marker of residual thyroid cancer or tumor recurrence. in patients with elevated tg levels and negative diagnostic radioiodine (131i) whole-body scans (dwbs), administration of a therapy dose may reveal foci that were not initially apparent. the aim of this study was to identify factors, other than 131i activity, which might explain why a post-therapy 131i whole-body scan is sometimes positive despite a negative dwbs. | 2009 | 19542747 |
| elevated free thyroxine levels detected by a neonatal screening system. | in sapporo city of japan, neonatal screening for congenital hypothyroidism has used the measurement of free thyroxine (t4) and thyroid-stimulating hormone (tsh) in the filter-paper blood spot. this system has enabled us to identify hyperthyroxinemic diseases. filter papers were collected from neonatal infants born at 4-6 d of age and neonates who showed elevated free t4 (>4.0 ng/dl, 4 sd above the mean) were studied. between january 2000 and december 2006, 83,232 newborns were screened. eleven i ... | 2009 | 19542904 |