| evaluation of cattle for experimental infection with and transmission of brucella suis biovar 4. | to determine whether cattle can become persistently infected with brucella suis biovar 4, whether the organism can be transmitted vertically or horizontally, and whether tests for bovine brucellosis are diagnostic. | 2003 | 12725315 |
| type iii secretion homologs are present in brucella melitensis, b. ovis, and b. suis biovars 1, 2, and 3. | protein sequences from characterized type iii secretion (tts) systems were used as probes in silico to identify several tts gene homologs in the genome sequence of brucella suis biovar 1 strain 1330. four of the genes, named flhb, flip, flir, and flif on the basis of greatest homologies to known flagellar apparatus proteins, were targeted in pcr and hybridization assays to determine their distribution among other brucella nomen species and biovars. the results indicated that flhb, flip, flir and ... | 2003 | 12732970 |
| subversion and utilization of the host cell cyclic adenosine 5'-monophosphate/protein kinase a pathway by brucella during macrophage infection. | brucella spp. are intramacrophage pathogens that induce chronic infections in a wide range of mammals, including domestic animals and humans. therefore, the macrophage response to infection has important consequences for both the survival of phagocytosed bacteria and the further development of host immunity. however, very little is known about the macrophage cell signaling pathways initiated upon infection and the virulence strategy that brucella use to counteract these responses and secure thei ... | 2003 | 12759440 |
| epitope mapping of the brucella melitensis bp26 immunogenic protein: usefulness for diagnosis of sheep brucellosis. | sequencing of bp26, the gene encoding the brucella sp. immunogenic bp26 periplasmic protein, was performed in the reference strains of brucella abortus, b. suis, and b. ovis. the three bp26 sequences were almost identical to that published for b. melitensis 16m bp26, and only minor nucleotide substitutions, without modifying the amino acid sequence, were observed between species. the bp26 genes of the seven b. abortus biovar reference strains and b. abortus s19 and rb51 vaccine strains were also ... | 2003 | 12853399 |
| characterization of new members of the group 3 outer membrane protein family of brucella spp. | impairment of the omp25 gene in brucella spp. leads to attenuated strains and confers protection to the host. omp25 and omp31, whose functions remain unknown, were the first characterized members of group 3 outer membrane proteins (omps) (25 to 34 kda). recently, genomic and proteomic approaches identified five new putative members of this family, some of which are produced in b. melitensis or b. abortus. in the present study, using protein microsequencing, we identified new members of group 3 o ... | 2003 | 12874309 |
| purification and characterization of an immunogenic aminopeptidase of brucella melitensis. | an immunogenic aminopeptidase was purified from brucella melitensis strain vtrm1. the purification procedure consisted of ammonium sulfate fractionation and three chromatographic steps. this procedure resulted in a yield of 29% and a 144-fold increase in specific activity. the aminopeptidase appeared to be a monomeric enzyme with a molecular mass of 96 kda and an isoelectric point of 4.8. its activity was optimal at ph 7.0 at 40 degrees c. the enzyme was strongly inhibited by edta, 1,10-phenathr ... | 2003 | 12933870 |
| fluorescence polarization assay for diagnosis of human brucellosis. | fluorescence polarization immunoassay (fpa) uses molecular rotational properties to measure antibody binding to antigen directly. the potential use of this method was assessed in comparison to a competitive enzyme immunoassay (celisa) and conventional serological tests for the diagnosis of brucellosis on a total of 587 human sera. based on 340 sera from asymptomatic blood donors with no evidence of brucellosis, the specificity of the fpa was 97.9 % using a cut-off value of 72 mp. sera from bruce ... | 2003 | 12972582 |
| effect of methionine upon utilization of dl-homocystine by brucella suis. | | 1952 | 12983395 |
| comparative metabolic studies on the genus brucella. i. evidence of a urea cycle from glutamic acid metabolism. | | 1952 | 12999700 |
| brucella suis infection in suckling and weanling pigs. i. | | 1952 | 13022509 |
| brucella suis infection in suckling and weanling pigs. | | 1952 | 13022528 |
| cutaneous hypersensitivity in brucellosis. i. characterization of an antigen for detection of cutaneous hypersensitivity in brucellosis. | | 1953 | 13035101 |
| cutaneous hypersensitivity in brucellosis. ii. chromatographic studies on the skin-test antigen. | | 1953 | 13035102 |
| the role of iron in the biology of brucella suis. i. growth and virulence. | | 1953 | 13069471 |
| on the problem of naturally occurring aberrant strains of brucella. | | 1954 | 13204346 |
| [case of brucella suis infection in poland]. | | 1954 | 13224518 |
| studies on mixed infections. ii. pathological effects of combined brucella suis and coxiella burnetii infection. | | 1955 | 13248333 |
| the use of triphenyltetrazolium chloride in the study of dehydrogenase activity of brucellae. | | 1955 | 13265234 |
| studies on respiratory infection. iii. experiments with brucella suis. | | 1956 | 13319690 |
| the establishment of colonial variants in guinea pigs infected with smooth brucella suis. | | 1956 | 13376920 |
| [isolation of brucella suis from a hare]. | | 1956 | 13420224 |
| nutritional factors influencing the polysaccharide production of brucella suis. | | 1957 | 13428709 |
| suppuration and calcification of the liver and spleen due to long standing infection with brucella suis. | | 1957 | 13452074 |
| [1st isolation of brucella suis from swine in poland]. | | 1957 | 13469292 |
| tissue culture studies on bacterial allergy in experimental brucellosis. i. the effect of brucella suis whole antigen on cultures of spleen from normal and brucella-infected guinea pigs. | tissue culture methods have been used to investigate infectious allergy in experimental brucellosis. a study was made of the effect of whole cell brucella antigen on cultures of spleen from normal and brucella-infected guinea pigs. the degree of toxicity was based upon the inhibition of migration of wandering cells and upon the morphologic appearance of stained sections of tissue cultures at different periods of incubation. a suspension of heat-killed br. suis was more toxic for splenic cells fr ... | 1958 | 13491765 |
| brucella suis infection of a child in eire. | | 1957 | 13492608 |
| the pathogenesis of brucella suis infection in guinea pigs: lesions of the spleen, liver, testis, and articulations. | | 1958 | 13537582 |
| studies on the antigenic structure of brucella suis with the aid of the agar gel precipitation technique. i. the resistance of antigens to physical, chemical and enzymatic treatments. | | 1958 | 13546544 |
| relationship of agar diffusion patterns to agglutinating and protective properties of brucella suis antisera. | | 1958 | 13572724 |
| a cellular basis of immunity in experimental brucella infection. | brucella suis, brucella abortus, and brucella melitensis were shown by microscopic and cultural procedures to multiply extensively within normal rat, mouse, and guinea pig monocytes maintained in vitro in cell cultures for 3 days. intracellular growth of brucellae had no observable toxic effects on most monocytes, although many of the cells became completely engorged with brucellae within 3 days. non-smooth brucellae and strain 19 multiplied slowly within normal monocytes. in contrast, "immune" ... | 1958 | 13575671 |
| characterization of intracellular, glucosidic polysaccharide produced by brucella suis. | | 1958 | 13587473 |
| studies on mixed infections. iii. influence of immunological factors in combined brucella suis and coxiella burnetii infection. | | 1958 | 13587484 |
| preliminary report on vaccines prepared from gamma-irradiated mycobacterium tuberculosis and brucella suis. | | 1959 | 13627447 |
| studies on mixed infections. iv. role of bacterial endotoxin in combined infection with brucella suis and coxiella burnetii. | | 1959 | 13630869 |
| studies on mixed infections. v. effect of stressor compounds in combined infection with brucella suis and coxiella burnetii. | | 1959 | 13630870 |
| [chromatographic studies on free and bound lipid fractions in brucella suis 44]. | | 1959 | 13670971 |
| metabolic characterization of the genus brucella. i. statistical evaluation of the oxidative rates by which type i of each species can be identified. | meyer, margaret e. (university of california, davis), and h. s. cameron. metabolic characterization of the genus brucella. i. statistical evaluation of the oxidative rates by which type i of each species can be identified. j. bacteriol. 82:387-395. 1961.-the oxidative uptake rates on 11 amino acid and seven carbohydrate substrates were determined for 75 strains of brucellae that had been identified by the conventional determinative methods as brucella melitensis type i, brucella abortus type i, ... | 1961 | 13770011 |
| metabolic characterization of the genus brucella. ii. oxidative metabolic patterns of the described biotypes. | meyer, margaret e. (university of california, davis), and h. s. cameron. metabolic characterization of the genus brucella. ii. oxidative metabolic patterns of the described biotypes. j. bacteriol. 82:396-400. 1961.-the oxidative metabolism of the biotypes of brucella abortus and brucella suis was compared to that of typical strains of these species. it was found that the biotypes of b. abortus display a metabolic pattern identical to that of b. abortus type i, irrespective of their differences i ... | 1961 | 13770012 |
| metabolic characterization of the genus brucella. iii. oxidative metabolism of strains that show anomalous characteristics by conventional determinative methods. | meyer, margaret e. (university of california, davis). metabolic characterization of the genus brucella. iii. oxidative metabolism of strains that show anomalous characteristics by conventional determinative methods. j. bacteriol. 82:401-410. 1961.-the oxidative metabolic patterns were determined on 83 strains of brucellae that had been described as "atypical" because they differed in one or more characteristics or because they had been isolated from an abnormal host (other than the natural reser ... | 1961 | 13770014 |
| the nature of pig antibodies against brucella suis. | | 1962 | 13894604 |
| pathogenicity and immunogenicity of streptomycin-dependent mutants of brucella. | simon, ellen m. (university of wisconsin, madison) and david t. berman. pathogenicity and immunogenicity of streptomycin-dependent mutants of brucella. j. bacteriol. 83:1347-1355. 1962.-streptomycin-dependent (sd) mutants of brucella suis and b. abortus were avirulent for guinea pigs whether selected in the presence of streptomycin only or streptomycin and normal or immune serum. administration of large quantities of streptomycin to guinea pigs increased the numbers of organisms which could be r ... | 1962 | 13913089 |
| [brucella suis and brucella phages]. | | 1963 | 13941555 |
| the isolation of brucella suis from rodents in kenya. | | 1963 | 13953489 |
| the behavior of brucella neotomae and brucella suis in reciprocal superinfection experiments in mice and guinea pigs. | | 1963 | 13984251 |
| [human brucellosis; study of the first 2 cases produced by "brucella suis" in our country]. | | 1962 | 14017569 |
| [phagocytic activity of the reticuloendothelial system in mice infected with "brucella suis"]. | | 1963 | 14046943 |
| safranine o: reliable selective dye for characterization of brucella suis. | | 1963 | 14066444 |
| thin-section electron micrographs of monocytes infected with brucella suis. | | 1963 | 14080786 |
| [the sensitivity of brucella melitensis and brucella suis to the tb brucellophage]. | | 1964 | 14131339 |
| [brucella phage plaques in cultures of brucella suis]. | | 1964 | 14132884 |
| [action exercised by brucella suis on experimental allergization by means of horse serum]. | | 1963 | 14166967 |
| fine structure of brucella suis spheroplasts. | hines, william d. (university of chicago, chicago, ill.), bob a. freeman, and gary r. pearson. fine structure of brucella suis spheroplasts. j. bacteriol. 87:1492-1498. 1964.-spheroplasts of brucella suis, prepared by treatment with penicillin and glycine, and normal cells were sectioned and studied by electron microscopy. these spheroplasts differed from the normal cell in that they were greatly expanded and coccoid in shape. the cell wall and cytoplasmic membrane were more easily demonstrated ... | 1964 | 14188733 |
| [on the histopathology and differential diagnosis of brucella suis infection in naturally infected rabbits]. | | 1964 | 14194795 |
| [studies concerning the effect of different rtd doses of brucella phages on brucella suis]. | | 1964 | 14211330 |
| cytopathogenic effect of brucella spheroplasts on monocytes in tissue culture. | freeman, bob a. (the university of chicago, chicago, ill.), and barry h. rumack. cytopathogenic effect of brucella spheroplasts on monocytes in tissue culture. j. bacteriol. 88:1310-1315. 1964.-mononuclear phagocytes from guinea pig peritoneal exudates were shown to ingest both normal brucella suis and spheroplasts prepared from b. suis by treatment with glycine and with penicillin. quantitative ingestion studies with p(32)-labeled brucella showed that rough normal brucella are ingested at a gre ... | 1964 | 14234786 |
| brucella suis infection of guinea-pigs by the respiratory route. | | 1955 | 14351638 |
| demonstration of an iron-activated aldolase in sonic extracts of brucella suis. | | 1955 | 14367307 |
| establishment of colonial variants of brucellae in vivo. | | 1955 | 14371687 |
| a rapid biochemical method for differentiation of brucella suis. peroxidase activity of brucella. | | 1959 | 14411849 |
| identification of species of brucella using fourier transform infrared spectroscopy. | fourier transform infrared spectroscopy (ftir) is a technique that has been used over the years in chemical analysis for the identification of substances and is one that may be applied to the characterisation of microorganisms. the marked tendency of brucella towards variation in the smooth rough phase, together with the laboriousness and risk involved in the methods used in their identification, make their classification difficult. we studied the type strains of the different species and biovar ... | 2003 | 14500003 |
| molecular characterization of brucella abortus chromosome ii recombination. | large-scale genomic rearrangements including inversions, deletions, and duplications are significant in bacterial evolution. the recently completed brucella melitensis 16m and brucella suis 1330 genomes have facilitated the investigation of such events in the brucella spp. suppressive subtractive hybridization (ssh) was employed in identifying genomic differences between b. melitensis 16m and brucella abortus 2308. analysis of 45 ssh clones revealed several deletions on chromosomes of b. abortus ... | 2003 | 14526025 |
| [evaluation of 2 hemoculture media for the isolation of brucella spp.]]. | the diagnostic efficiency of two hemoculture media for the detection of different species of brucella strains was evaluated. strains of brucella melitensis, brucella suis, brucella abortus, brucella ovis, and brucella abortus s19 were used. each strain was diluted in phosphate buffer saline (pbs) to obtain a concentration of 10(5) colony forming units/ml (cfu/ml). blood from goats, pigs, cattle, and sheep was mixed with the bacterial suspension to obtain a final concentration minor or equal to 1 ... | 2003 | 14587372 |
| wild boars (sus scrofa) as reservoirs of brucella suis biovar 2 in croatia. | this work presents the results of findings for brucellosis in wild boars and domestic swine in two regions of croatia. in the region of djakovo the blood samples of 211 wild boars were analysed and in 29.4% of the samples serologically positive reactions were established. in the same region the blood samples of 1080 domestic swine on pastures were also analysed and positive serological reactions were established in 12.3%. in the regions around lonjsko polje the blood samples of 53 wild boars wer ... | 2003 | 14680058 |
| antibody reactivity to omp31 from brucella melitensis in human and animal infections by smooth and rough brucellae. | group 3 of outer membrane proteins (omps) of brucella includes omp25 and omp31, which share 34% identity. omp25 is highly conserved in brucella species, and omp31 is present in all brucella species, except brucella abortus. antibodies to brucella melitensis omp31 have been sought only in infected sheep, and western blotting of sera from infected sheep did not reveal anti-omp31 reactivity. we obtained recombinant purified omp31 (b. melitensis) and tested its recognition by sera from humans and an ... | 2004 | 14715555 |
| failures with aureomycin in the treatment of infection with brucella suis; a report of three cases. | | 1950 | 14774107 |
| [hydrolysis of the antigen complex of brucella suis and the chemical nature of components]. | | 1951 | 14811889 |
| marked resistance of swine to brucella suis. | | 1951 | 14836086 |
| the bactericidal action in vivo of aureomycin in an aureomycin fermentation residue against brucella suis. | | 1951 | 14840005 |
| studies on the pathogenicity of brucella suis for cattle. | | 1951 | 14847107 |
| studies in the pathology and pathogenesis of experimental brucellosis. i. a comparison of the pathogenicity of brucella abortus, brucella melitensis, and brucella suis for guinea pigs. | | 1951 | 14861464 |
| [antigens of brucella suis; isolation, purification and chemical characteristics]. | | 1950 | 14869315 |
| [hydrolysis of antigen complex of brucella suis and chemical nature of components]. | | 1951 | 14895511 |
| studies of sulfur metabolism of brucella suis. | | 1951 | 14897832 |
| the comparative effect of related chemical groups on the growth of three species of brucella. | | 1952 | 14924103 |
| susceptibility of cattle to brucella suis following vaccination with brucella abortus strain 19. | | 1952 | 14924107 |
| reversal of thionine inhibition by various substrates on brucella suis. | | 1952 | 14924133 |
| anaerobic glycolysis by enzyme preparations of brucella suis. | | 1952 | 14927609 |
| the bactericidal action of dog blood against brucella suis. | | 1952 | 14946422 |
| virb1 orthologs from brucella suis and pkm101 complement defects of the lytic transglycosylase required for efficient type iv secretion from agrobacterium tumefaciens. | type iv secretion systems mediate conjugative plasmid transfer as well as the translocation of virulence factors from various gram-negative pathogens to eukaryotic host cells. the translocation apparatus consists of 9 to 12 components, and the components from different organisms are believed to have similar functions. however, orthologs to proteins of the prototypical type iv system, virb of agrobacterium tumefaciens, typically share only 15 to 30% identical amino acids, and functional complemen ... | 2004 | 14973016 |
| brucella pathogenesis, genes identified from random large-scale screens. | pathogenicity islands, specialized secretion systems, virulence plasmids, fimbriae, pili, adhesins, and toxins are all classical bacterial virulence factors. however, many of these factors, though widespread among bacterial pathogens, are not necessarily found among bacteria that colonize eukaryotic cells in a pathogenic/symbiotic relationship. bacteria that form these relationships have developed other strategies to infect and grow in their hosts. this is particularly true for brucella and othe ... | 2004 | 14979322 |
| impairment of intramacrophagic brucella suis multiplication by human natural killer cells through a contact-dependent mechanism. | brucella spp. are facultative intracellular bacteria that can establish themselves and cause chronic disease in humans and animals. nk cells play a key role in host defense. they are implicated in an early immune response to a variety of pathogens. however, it was shown that they do not control brucella infection in mice. on the other hand, nk cell activity is impaired in patients with acute brucellosis, and recently it was demonstrated that human nk cells mediate the killing of intramacrophagic ... | 2004 | 15039355 |
| different responses of macrophages to smooth and rough brucella spp.: relationship to virulence. | by comparing smooth wild-type brucella strains to their rough mutants, we show that the lipopolysaccharide (lps) o side chain of pathogenic brucella has a dramatic impact on macrophage activation. it favors the development of virulent brucella by preventing the synthesis of immune mediators, important for host defense. we conclude that this o chain property is firmly linked to brucella virulence. | 2004 | 15039375 |
| brucella osteomyelitis of the proximal tibia: a case report. | brucellosis is a disease of domestic and wild animals that is transmittable to humans. although endemic in some parts of the world, brucellosis is an uncommon human pathogen in the united states. the clinical presentation of brucellosis is nonspecific, and brucella osteomyelitis can produce lytic lesions on radiographs that resemble neoplasm. diagnosis can therefore be difficult unless a high index of suspicion is maintained. we present a case of brucella osteomyelitis of the proximal tibia that ... | 2004 | 15296202 |
| an epidemiological profile of brucellosis in tabuk province, saudi arabia. | all 137 brucellosis cases occurring in tabuk province, saudi arabia in 1997 were studied retrospectively. brucella agglutination titre of > or = 1/80, or rising titre plus history of typical signs and symptoms were considered evidence of infection. the incidence rate was 34/100,000, mean age 33.8 +/- 13.9 years (range: 3-72 years) and male:female ratio 1.8:1. there were 63.5% of cases rurally resident, 58.4% kept animals at home or elsewhere, 27.0% worked with animals and/or on farms, and 88.3% ... | 2001 | 15332781 |
| dna polymorphism in the omp25/omp31 family of brucella spp.: identification of a 1.7-kb inversion in brucella cetaceae and of a 15.1-kb genomic island, absent from brucella ovis, related to the synthesis of smooth lipopolysaccharide. | five genes homologous to the well-known omp25 and omp31 genes, that code for two major brucella spp. outer membrane proteins (omps), have been detected in the genome of brucella melitensis 16m and brucella suis 1330. in this work we have determined the nucleotide sequence of these five genes, named omp31b, omp25b, omp25c, omp25d and omp22, in the six classical brucella species reference strains and in representative strains of the recently proposed species brucella cetaceae and brucella pinniped ... | 2004 | 15374004 |
| release of periplasmic proteins of brucella suis upon acidic shock involves the outer membrane protein omp25. | the survival and replication of brucella in macrophages is initially triggered by a low intraphagosomal ph. in order to identify proteins released by brucella during this early acidification step, we analyzed brucella suis conditioned medium at various ph levels. no significant proteins were released at ph 4.0 in minimal medium or citrate buffer, whereas in acetate buffer, b. suis released a substantial amount of soluble proteins. comparison of 13 n-terminal amino acid sequences determined by ed ... | 2004 | 15385468 |
| epidural abscess secondary to brucellosis, brucella suis. | | 1950 | 15405291 |
| brucella suis infection treated with aureomycin; case report. | | 1950 | 15412345 |
| a urease test for the differentiation of brucella suis. | | 1950 | 15436442 |
| efficacy of several serological tests and antigens for diagnosis of bovine brucellosis in the presence of false-positive serological results due to yersinia enterocolitica o:9. | yersinia enterocolitica o:9 bears a smooth lipopolysaccharide (s-lps) of brucella sp. o-chain a+c/y epitopic structure and is a cause of false-positive serological reactions (fpsr) in standard tests for cattle brucellosis. brucella s-lps, cross-reacting s-lpss representing several o-chain epitope combinations, brucella core lipid a epitopes (rough lps), brucella abortus s-lps-derived polysaccharide, native hapten polysaccharide, rough lps group 3 outer membrane protein complexes, recombinant bp2 ... | 2005 | 15642999 |
| vgamma9vdelta2 t cells use a combination of mechanisms to limit the spread of the pathogenic bacteria brucella. | human vgamma9vdelta2 t cells play a crucial role in early immune response to intracellular pathogens. in brucellosis infection, this population of cells is drastically increased in the peripheral blood of patients during the acute phase of infection. in vitro, vgamma9vdelta2 t cells exhibit strong cytolytic activity against brucella-infected cells and are able to impair intracellular growth of brucella suis in autologous macrophages. in this study, we have investigated the relative importance of ... | 2005 | 15668339 |
| cloning, expression, and purification of brucella suis outer membrane proteins. | brucella, an aerobic, nonsporeforming, nonmotile gram-negative coccobacillus, is a nih/cdc category b bioterror threat agent that causes incapacitating human illness. medical defense against the bioterror threat posed by brucella would be strengthened by development of a human vaccine and improved diagnostic tests. central to advancement of these goals is discovery of bacterial constituents that are immunogenic or antigenic for humans. outer membrane proteins (omps) are particularly attractive f ... | 2005 | 15721781 |
| secondary structure in the target as a confounding factor in synthetic oligomer microarray design. | secondary structure in the target is a property not usually considered in software applications for design of optimal custom oligonucleotide probes. it is frequently assumed that eliminating self-complementarity, or screening for secondary structure in the probe, is sufficient to avoid interference with hybridization by stable secondary structures in the probe binding site. prediction and thermodynamic analysis of secondary structure formation in a genome-wide set of transcripts from brucella su ... | 2005 | 15755320 |
| structures of two core subunits of the bacterial type iv secretion system, virb8 from brucella suis and comb10 from helicobacter pylori. | type iv secretion systems (t4sss) are commonly used secretion machineries in gram-negative bacteria. they are used in the infection of human, animal, or plant cells and the propagation of antibiotic resistance. the t4ss apparatus spans both membranes of the bacterium and generally is composed of 12 proteins, named virb1-11 and vird4 after proteins of the canonical agrobacterium tumefaciens t4ss. the periplasmic core complex of virb8/virb10 structurally and functionally links the cytoplasmic ntpa ... | 2005 | 15764702 |
| completion of the genome sequence of brucella abortus and comparison to the highly similar genomes of brucella melitensis and brucella suis. | brucellosis is a worldwide disease of humans and livestock that is caused by a number of very closely related classical brucella species in the alpha-2 subdivision of the proteobacteria. we report the complete genome sequence of brucella abortus field isolate 9-941 and compare it to those of brucella suis 1330 and brucella melitensis 16 m. the genomes of these brucella species are strikingly similar, with nearly identical genetic content and gene organization. however, a number of insertion-dele ... | 2005 | 15805518 |
| from the discovery of the malta fever's agent to the discovery of a marine mammal reservoir, brucellosis has continuously been a re-emerging zoonosis. | brucellosis is not a sustainable disease in humans. the source of human infection always resides in domestic or wild animal reservoirs. the routes of infection are multiple: food-borne, occupational or recreational, linked to travel and even to bioterrorism. new brucella strains or species may emerge and existing brucella species adapt to changing social, cultural, travel and agricultural environment. brucella melitensis is the most important zoonotic agent, followed by brucella abortus and bruc ... | 2005 | 15845228 |
| requirement of mgtc for brucella suis intramacrophage growth: a potential mechanism shared by salmonella enterica and mycobacterium tuberculosis for adaptation to a low-mg2+ environment. | a brucella suis mgtc mutant is defective for growth within macrophages and in low-mg(2+) medium. these phenotypes are strikingly similar to those observed with mgtc mutants from salmonella enterica and mycobacterium tuberculosis, two other pathogens that proliferate within phagosomes. mgtc appears as a remarkable virulence factor that would have been acquired by distantly related intracellular pathogens to contribute to the adaptation to a low-mg(2+) environment in the phagosome. | 2005 | 15845525 |
| isolation of brucella suis biovar 3 from horses in croatia. | | 2005 | 15866906 |
| human brucellosis in a nonendemic country: a report from germany, 2002 and 2003. | human brucellosis has become a rare disease in germany since the eradication of bovine and ovine/caprine brucellosis in this country. therefore, most physicians are unfamiliar with the illnesses clinical presentation, diagnostic tools, and therapeutic strategies. this retrospective study was carried out to evaluate the epidemiological, clinical, and laboratory features of human brucellosis in germany in the years 2002 and 2003. thirty-one bacterial isolates from 30 patients sent to the german na ... | 2005 | 15959815 |
| putative outer membrane autotransporter protein influences survival of brucella suis in balb/c mice. | in gram-negative bacteria, autotransporters are secreted proteins able to translocate themselves through the inner- and outer-membranes to the cell surface or to the extracellular environment. the influence of the putative outer membrane autotransporter (omaa) protein to the persistence of brucella suis was investigated. sequence analyses revealed that the omaa protein of b. suis strain 1330 consists of a signal peptide, a passenger alpha-domain, and a transporter beta-domain, which are the char ... | 2005 | 15970403 |