| effects of plant and animal lipids rich in docosenoic acids on the myocardium of cynomolgus monkeys. | cynomolgus monkeys (macaca fascicularis) were fed diets containing 25% rapeseed oil (rso), partially-hydrogenated herring oil (phho) or a 3:1 mixture of lard/corn oil as control (con) for 4 months. the rso contained approximately 25% of the fatty acids as erucic acid (cis-docos-13-enoic, 22:1w9) while the phho contained a similar concentration of mainly cetoleic acid (cis-docos-11-enoic, 22:1w11). the con contained no 22:1 acids. the monkeys developed the expected myocardial lipidosis, somewhat ... | 1978 | 416402 |
| blood groups of pig-tailed macaques (macaca nemestrina). | the human-type a-b-o blood groups of 57 pig-tailed macaques (macaca nemestrina) were determined and the calculated gene frequencies, o = 0.8908, a = 0.0825 and b = 0.0267, gave excellent fit with the hypothesis of inheritance by triple allelic genes. in tests for simian-type blood groups with rhesus, baboon and crab-eating macaque immune antisera, it was shown that the red cells of pig-tailed macaques are polymorphic for several simian-type specificities defined by those cross-reacting sera. pig ... | 1978 | 416724 |
| [fluorescence histochemical studies on the monoamine-containing neurons and their pathways in the brain stem of the java monkey (macaca irus)--stereotaxic demonstration of the localization (author's transl)]. | | 1977 | 416765 |
| surface processes of olfactory receptors. | the free surface morphology of olfactory receptor cells from the nasal mucosa of cynomolgus monkeys was studied electron microscopically. the receptor cell, in addition to showing characteristic cilia, possess several branched or unbranched shorter elevations or spiny processes covered by numerous delicate lace-like filaments not previously described. these filaments diminish in length and number toward the base of the microvillous protrusions. | 1978 | 416912 |
| static lung mechanics of intact and excised rhesus monkey lungs and lobes. | subdivisions of lung volume and pressure-volume (pv) curves of the lung and chest wall (cw) were measured in 12 rhesus monkeys (macacca mulatta) under pentobarbital anesthesia. in addition, volumes and pv curves were obtained on the excised lungs and lobes of 12 cynomolgus monkeys (m. fasicularis). boyle's law was used to determine functional residual capacity (frc) in the intact animals and water displacement to determine minimal volume (mv) in the excised lungs. total lung capacity (tlc = lung ... | 1978 | 417053 |
| [the importance of interferon for rabies prophylaxis (author's transl)]. | the importance of interferon for the prophylaxis of rabies is not yet fully understood. about 50% of cynomolgus monkeys infected with rabies virus could be protected from the disease with human interferon which was administered at a total dose of 1--10 million units per animal either intramuscularly 24 hours after infection or by intralumbar injection up to 11 days after. the clinical relevance of the findings is discussed. | 1978 | 417241 |
| prevention of hypercholesterolemia in monkeys (macaca fascicularis) by digitonin. | digitonin mixed in the diet was well tolerated by rats and cynomolgus monkeys (macaca fascicularis), and prevented the expected rise in plasma cholesterol in monkeys fed a diet containing butter and cholesterol. both digitonin and mildly hydrolyzed digitonin precipitated cholesterol dispersed in micellar suspensions and decreased intestinal absorption of cholesterol in rats, but only digitonin bound cholesterol in vitro. the hypocholesterolemic effect of digitonin may be secondary to decreased i ... | 1978 | 417616 |
| effects of ischemia on the oxygen diffusion coefficients in the brain cortex (studies on macaca irus). | in this series of experiments changes in oxygen diffusion coefficients were measured in waking primates undergoing focal middle cerebral artery ischemia; ligation of the middle cerebral artery followed by a decrease of the oxygen diffusion coefficient in the areas supplied by that vessel to levels ten to twenty per cent below normal by twenty-five minutes following onset of ischemia. following release and re-perfusion diffusion coefficient gradually increases and reaches a super normal peak valu ... | 1977 | 418626 |
| anticholinesterase-induced cholinergic subsensitivity in primate accommodative mechanism. | i treated cynomolgus monkeys with topical echothiophate iodide twice daily for several months. accommodative responses to topical or intramuscular pilocarpine were determined after ciliary ganglion or cholinergic nerve blockade. during echothiophate treatment, there was little or no accommodative response to intramuscular pilocarpine doses which were near maximal in nonechothiophate-treated eyes. similarly, echothiophate-treated eyes demonstrated little or no response to topical pilocarpine dose ... | 1978 | 418688 |
| craniofacial adaptations after total maxillary osteotomy in macaca irus: a cephalometric and histologic study. | five macaca irus monkeys were used in this study to determine cephalometric and histologic changes after total maxillary impactions. in the three experimental animals, the maxilla was impacted 5 to 7 mm. and lateral cephalograms were taken over a 150-day period. by superimposing on craniofacial implants, osseous and dental changes were measured. excellent skeletal stability was demonstrated during the postoperative period. histologically, there was normal osseous healing of the osteotomized maxi ... | 1978 | 418689 |
| carcinogenic and other adverse effects of procarbazine in nonhuman primates. | the carcinogenic potential of procarbazine is under investigation in three species (macaca mulatta, macaca fascicularis, and cercopithecus aethiops) of nonhuman primates. a total of 55 monkeys have received procarbazine s.c., p.o., or i.p. for periods of up to 12 years. eleven of the 42 monkeys (26%) necropsied thus far have had malignant neoplasms, 6 of which were acute leukemia. two monkeys developed osteogenic sarcomas, two monkeys developed hemangiosarcomas, and a single case of lymphocytic ... | 1978 | 418874 |
| between-ovary interaction in the regulation of follicle growth, corpus luteum function, and gonadotropin secretion in the primate ovarian cycle. i. effects of follicle cautery and hemiovariectomy during the follicular phase in cynomolgus monkeys. | | 1979 | 436777 |
| experimental analysis of temporomandibular joint reaction force in macaques. | mandibular bone strain in the region immediately below the temporomandibular ligament was analyzed in adult and sub-adult macaca fascicularis and macaca mulatta. following recovery from the general anesthetic, the monkeys were presented food objects, a wooden rod, or a specially designed bite-force transducer. bone strain was recorded during incisal biting and mastication of food, and also during isometric biting of the rod and/or the transducer. the bone strain data suggest the following: the m ... | 1979 | 532828 |
| erythroblastosis models. ii. materno-fetal incompatibility in chimpanzee. | erythroblastosis fetalis represents a significant hazard for successful management of pregnancy in man and in marmosets, but not in crab-eating macaques. materno-fetal blood group incompatibility in chimpanzee is described as a contributing factor in the death of an infant. the findings indicate that parental blood groups should be taken into consideration when breeding chimpanzees. | 1977 | 556709 |
| nursery rearing of infant monkeys (macaca fascicularis) for toxicity studies. | at birth, nine infant male cynomolgus monkeys (macaca fascicularis) weighed an average of 402 g and 16 infant female cynomolgus monkeys weighed an average of 362 g. both female and male infants last 15-20 g by the fourth day after birth. female and male infants showed a growth rate of approximately 4 and 5 g body wt/day, respectively, from 4 to 150 days of age. caloric intake increased from approximately 140 cal/gkg body weight/day in both females and males on the first day after birth to peak v ... | 1977 | 557707 |
| the electrocardiogram of macaca fascicularis. | electrocardiograms from 16 male cynomolgus monkeys (macaca fascicularis) were studied. standard and augmented limb leads (i, ii, iii, avr, avl, avf) were obtained with the animals restrained in a sitting position. normal electrocardiographic parameters were determined, including pr and qt intervals; p, qrs, and t wave axes; p and qrs wave widths. voltages in all standard and augmented limb leads were lower than previously reported for similar size monkeys. | 1978 | 642439 |
| the c-wave of the human electroretinogram in central retinal artery occlusion. | the pigment epithelium-receptor complex, which is supplied from the choroidal circulation, is the main source of the c-wave of the erg. occlusion of the central retinal artery (ocra), which causes serious damage to the inner retinal layers, should therefore not primarily be expected to affect the c-wave amplitude. nevertheless, conflicting reports of increased, decreased and unchanged c-waves have appeared in the literature. in the present study on four patients with ocra the affected eyes showe ... | 1978 | 696268 |
| intrauterine ethanol-induced termination of pregnancy in cynomolgus monkeys (macaca fascicularis). | the effectiveness of locally applied ethanol in terminating early pregnancy in cynomolgus monkeys was studied. in a randomized trial ethanol (70 per cent, 1 ml.) or saline (0.9 per cent, 1 ml.) was injected extra-amniotically through a sterile blunt-end needdle inserted through the cervix into the uterine cavity. six of seven monkeys receiving ethanol showed vaginal bleeding beginning one or two days after treatment. with the one failure, alcohol leakage occurred from the luer-lock needle joint ... | 1978 | 717489 |
| t-strain mucoplasmas and reproductive failure in monkeys. | t-strain mycoplasmas were isolated from the genital tracts of 3 genera of female monkeys: the talapoins, miopithecas talapoin, the patas, erythrocebus patas, and the macaques, macaca fascicularis. the talapoins have not reproduced successfully for the past 2 yr. fertility in the patas has also been reduced, with a high incidence of stillbirths and spontaneous abortions. the macaques were not permitted to breed. | 1975 | 805883 |
| the application of qae-sephadex for the purification of two staphylococcal enterotoxins. ii. purification of enterotoxin a. | the last three steps described in the preceding communication robern, h., stavric, s. and dickie, n. (1975) biochim. biophys. acta 000,000-000) were utilized successfully for the purification of enterotoxin a. the enterotoxin appeared homogeneous by gel chromatography and in the analytical ultracentrifuge but showed two bands on polyacrylamide disc electrophoresis at ph 4.5. the emetic dose, ed50, by intravenous route in cynomolgus monkeys was 0.12 mug/kg of animal weight. after treatment with b ... | 1975 | 806302 |
| effect of sodium phytate on the chemical and microbial composition of dental plaque in the monkey (macaca fascicularis) | the incorporation of 1 or 3% sodium phytate in confectioners sugar produced minimal changes in the physical,chemical, and microbial composition of dental plaque in tube-fed monkeys during a two-week period. only a reduction in yeasts and lactobacilli could be ascribed to the presence of phytate. other changes were attributable to the transition from conventional feeding to tube-feeding, irrespective of the presence of absence of phytate. | 1975 | 806617 |
| the influence of 2 br-alpha-ergocryptine (cb-154) and apomorphine on induced prolactin secretion in the crab eating monkey (macaca fascicularis). | the influence of apomorphine and 2 br-alpha-ergocryptine (cb-154) on drug-induced prolactin secretion was examined in an intact and an ovariectomized monkey (macaca fascicularis). perphenazine administered iv at one mg/kg bw induced a rapid and marked increase in serum prolactin. apomorphine at a concentration of 4 mg/kg bw administered prior to perphenazine delayed the perphenazine-induced prolactin rise. the iv administration of cb-154 at either 200 or 2000 mu-g/kg bw completely blocked the pe ... | 1975 | 807469 |
| sulphated macromolecules in dental plaque in the monkey macaca irus. | | 1975 | 808203 |
| experimental oroparanasal communication in monkeys. | experimental oroparanasal communications were established in nine monkeys (macaca irus) through the alveoli of the maxillary first or second molars after extraction of these teeth. the communications between the maxillary sinus and the oral cavity were supported by use of a polyethylene catheter fixed with sutures. the observation time ranged from 1 to 6 days. histologic study of the maxillary sinus mucous membrane revealed inflammatory changes especially in the floor and the lower part of the w ... | 1975 | 808503 |
| erythroblastosis models. a review and new experimental data in monkeys. | the current status of erythroblastosis fetalis in man and in animals is briefly reviewed with emphasis on present knowledge of nonhuman primates as models for the disease. our studies in crab-eating macaques indicate that presence in a mother's serum of potent antibodies reactive for red cells for her fetus will not necessarily cause erythroblastosis; in one case the maternal antibodies did not penetrate the placental barrier, and in two cases although the fetal red cells were maximally antibody ... | 1975 | 808623 |
| maximum expiratory flow-volume studies on monkeys exposed to bituminous coal dust. | to assess early ventilatory responses at the 2 mg/m3 bituminous coal dust standard, 23 cynomolgus monkeys were exposed by inhalation to pennsylvania and utah coal dust. ten controls were utilized. pennsylvania coal was selected from a field having a high prevalence of coal workers' pneumoconiosis while the utah coal was selected from a low prevalence area. after 24 mo of exposure, a pattern of pulmonary impairment consistent with peripheral airway obstruction was demonstrated. reductions were ob ... | 1975 | 809410 |
| [retinal reactions to intense light. i. threshold lesions. experimental, morphological and clinical studies of pathological and therapeutic effects of laser and white light]. | the effects of intense light produced by an argon laser, a helium-neon laser and a xenon are photocoagulator in the retinas of gray chinchilla rabbits, cynomolgus monkeys, and rhesus monkeys were studied clinically and histopathologically including electron microscopy. an improved experimental set-up was used allowing a very good consistency of the inflicted lesions. threshold lesions were produced in chinchilla rabbits and cynomolgus monkeys by an argon laser and a helium-neon laser. the lesion ... | 1975 | 810008 |
| sinusoidal flicker characteristcis of primate cones in response to heterochromatic stimuli. | electrophysiological recordings of primate photorecptors have been obtained and frequency response characteristics of the red, green and blue cones have been determined and compared to previous psychophysical findings. using cynomolgus monkeys, we recorded the foveal local electroretinogram, which is dominated by the late receptor potential, and obtained criterion-response threshold data for sinusoidally flickered test stimuli complementary chromatic adapting backgrounds. our results support the ... | 1975 | 810550 |
| effective body water half-life and total body water in rhesus and cynomolgus monkeys. | although body water content and effective water half-life have been determined in several mammalian species, including man, these measurements are not available for sub-human primates to our knowledge. values were therefore determined in a group of rhesus and cynomolgus monkeys. a fairly wide range of water half-life values was found in each of the two species between animals, but there was little variation within animals who had more than one determination over the course of 1 year. mean values ... | 1975 | 811339 |
| [changes in cellular activity in corpus luysi after stimulation of monkey corpus striatum]. | in a chronic experiment on three awake macaca cynomolgus, the activity of 27 neurons localized in the corpus luysi was recorded. their spontaneous activity is continuous without rhythmicity or bursts. all neurons responded to a stimulation of the striatum by an initial activation followed by an inhibition. these facts reveal the occurrence of a double projection from the putamen and also from the head of the caudate nucleus to the corpus luysi. | 1975 | 811384 |
| [characterization of mycoplasms isolated from imported nonhuman primates (author's transl)]. | mycoplasms were isolated from 35 (16%) of 215 specimens collected from 20 crab-eating monkeys (macaca irus), 9 green monkeys (cercopithecus aethiops) and from 9 common squirrel monkeys (saimiri sciurea). all these animals had been imported from south-east asia, africa and south america being apparently healthy. a total of 38 large and 20 small colony-mycoplasma strains were isolated from the nasal and oral cavity, urethra, vagina and rectal feces. the large colony-mycoplasmas could be differenti ... | 1975 | 811474 |
| resistance to psychopathology in adolescent monkeys (macaca fascicularis) reared with mothers and peers. | | 1975 | 811699 |
| clinical note--a case of bilateral dental fistula in a cynamolgus monkey (macaca fascicularis). | | 1975 | 811928 |
| ocular effects of clonidine in cats and monkeys (macaca irus). | | 1975 | 812714 |
| schistosoma japonicum: immunopathology of nephritis in macaca fascicularis. | | 1975 | 812719 |
| atherosclerosis in rhesus and cynomolgus monkeys. | | 1976 | 813206 |
| distribution of an 125i-labelled chloroquine analogue in a pregnant macaca monkey. | whole body autoradiography of a pregnant monkey (macaca irus) of late gestation was performed 72 h after an intravenous injection of the 125i-labelled chloroquine analogue 4-(3-dimethylaminopropylamino)-7-iodoquinoline (dapq). the overall distribution pattern in the monkey was similar to that which was earlier observed in rodents. a few species differences, however, were found in the monkey as compared to the rodents: a high accumulation in the inner part of the adrenal cortex, a high level in t ... | 1975 | 813334 |
| [artificial nursing of new-born cynomolgus monkeys as a model of the human infant and development of abnormal behavior (author's transl)]. | new-born cynomolgus monkeys were sucessfully reared by artificial nursing that was started just afterbirth with a 12% solution of a commercially prepared powdered-milk (yukijirushi, p 7a) containing 13.3g of protein per 100g. marked growth-retardation was observed in baby cynomolgus monkeys fed on a 12% solution of the modified p 7a milk containing only 6.6g of protein per 100g to which lactose was supplemented to give a baby monkey the same caloric value as that of the original p 7a milk. these ... | 1975 | 814006 |
| [the weight of the reproductive organs, hypophysis and thyroid of male cynomolgus monkeys. (macaca fascicularis) (author's transl)]. | the present short paper deals with the weight of the male reproductive organs of wild-imported cynomolgus monkeys, including the testes, epididymides, ductus deferens, vesicula seminalis prostata, bulbo urethralis and penis. in addition, the size of the testes and the weight of the thyroid and hypophysis are also presented. | 1975 | 814007 |
| failure of carbon monoxide to induce myocardial infarction in cholesterol-fed cynomolgus monkeys (macaca fascicularis). | twenty-six adult female cynomolgus monkeys (macaca fascicularis) were randomly assigned to four groups which were fed on a standard laboratory diet or a semipurified diet containing cholesterol. in two of the groups, the monkeys were exposed intermittently to co throughout the day for 14 months; the control animals breathed room air. no myocardial infarctions were observed, and the ecg showed a transitory injury current in only one animal. no differences in plasma cholesterol levels or in aortic ... | 1976 | 815001 |
| experimental dirofilariasis in macaques. iii. susceptibility and host responses to dirofilaria tenuis of raccoons. | in this third of a series of studies on experimental dirofilariasis in primate hosts, 3 macaca cynomolgus, 6 m. speciosa, and 2 m. mulatta were inoculated with infective larvae of dirofilaria tenuis, a parasite of the raccoon, and were killed at periods ranging from 2 weeks to 13 months of infection. one m. mulatta and one m. speciosa were treated daily with prednisolone beginning 2 months after inoculation; worms were recovered from these and 5 other monkeys (7 of 11). microfilaremia was detect ... | 1976 | 816216 |
| thalamic projections from the precentral motor cortex in macaca fascicularis. | radioactive amino acids were injected into area 4 in 7 monkeys (macaca fascicularis). ipsilateral corticothalamic projections were traced to olszewski's nucleus ventralis lateralis pars oralis and pars medialis, the nucleus ventralis posterior lateralis pars oralis, the nucleus ventralis posterior medialis and inferior and to the nucleus reticularis. some fibers appeared to terminate in the ipsilateral nucleus ventralis lateralis pars caudalis, the nucleus lateralis posterior and the nucleus sub ... | 1976 | 816421 |
| immunization of macaca fascicularis (macaca irus) monkeys with streptococcus mutans: specificity of antibody responses in saliva. | m fascicularis monkeys were immunized subcutaneously in the vicinity of the major salivary glands and by retrograde infusion into the parotid duct, with a vaccine containing formalin-killed s mutans strain 6715 cells and culture-fluid antigens. indirect immunofluorescent staining was used to titrate and classify antibodies. subcutaneous immunization induced only a serum response, whereas intraductal infusion stimulated both an iga antibody response in the parotid fluid and a serum response. immu ... | 1976 | 816835 |
| aggravation of atherosclerosis by hypertension in a subhuman primate model with coarctation of the aorta. | the interrelationships between hypertension and atherosclerosis were investigated in a subhuman primate model (cynomolgus monkey) with hypertension produced by surgically coarcting the miathoracic aorta. the hypertensive coarcted monkey fed a low cholesterol diet for 6 months did not develop complicating atherosclerosis but did develop focal intimal lesions as well as marked thickening of the musculoelastic media of both the large and small arteries. fibrocellular thickening of the intima and me ... | 1976 | 817849 |
| immunoglobulins a, g, and m in serum and in some secretions of monkeys (macaca fascicularis syn. irus). | the purpose of this investigation was to study the distribution and levels of the following immunoglobulins, iga, igg, and igm ,in sera and in some secretions of monkeys (m. fascicularis). igg, iga, and igm were isolated from monkey serum and secretory iga was separated from monkey milk by combined gel filtration and ion-exchange chromatography. these pure preparations served as standards to quantitate immunoglobulins in sera and secretions by single radial immunodiffusion. antisera were raised ... | 1976 | 818024 |
| proliferative epithelial lesions of the urinary bladder in cynomolgus monkeys (macaca fascicularis) infected with schistosoma intercalatum. | five cynomolgus monkeys (macaca fascicularis) were infected with schistosoma intercalatum, a helminth that is morphologically similar to schistosoma haematobium. infections were readily established and remained active until the monkeys were sacrificed 21 to 84 weeks after exposure. although the schistosomes were located predominantly in mesenteric and hepatic portal venules, schistosome eggs were found in the bladders of 3 monkeys. nodules of atypical epithelial cells interpreted as superficiall ... | 1976 | 819136 |
| the effect of entrapment in liposomes on the in vivo distribution of [3h]methotrexate in a primate. | entrapment of methotrexate (mtx) plus [3',5', 9(n)-3h]methotrexate into positively charged liposomes greatly alters the subsequent distribution of [3h]mtx in a cynomologous monkey (macaca irus) after a single i.v. injection ([3h]mtx; refers to total radioactivity derived from purified [3h]mtx). when [3h]mtx is incorporated into small, sonically disrupted liposomes, the level of the entrapped [3h]mtx in the total plasma volume was still 50% of the total injected dose after 4 hr, which is 100 time ... | 1976 | 819137 |
| residual pilocarpine effects on outflow facility after ciliary muscle disinsertion in the synomolgus monkey. | outflow facility responses to pilocarpine were determined in ten cynomolgus monkey eyes after disinsertion of the ciliary muscle from the scleral spur. the effect of large intravenous dose given on one occasion was compared to the effect of intense topical treatment for 18 to 24 hours on another occasion. the effect of the two modes of treatment differed from eye to eye, but were similar in the individual eye. in some eyes facility rose while in others it fell. the average effect of both treatme ... | 1976 | 819392 |
| evaluation and re-evaluation of genetic radiation hazards in man. ii. the arm number hypothesis and the induction of reciprocal translocations in man. | the arm number hypothesis proposed by brewen and collagues in 1973 has been examined in the light of information thus far available from mammalian studies. in experiments with peripheral blood lymphocytes (radiation in vitro), a linear relationship between dicentric yield and the effective chromosome arm number of the species was obtained in the mouse, chinese hamster, goat, sheep, pig, wallaby and man. however, the data are not consistent with such a relationship in several primate species (ma ... | 1976 | 819823 |
| responses of subthalamic and pallidal neurons to striatal stimulation: an extracellular study on awake monkeys. | the unitary activity of subthalamic neurons (corpus luysii) and of gp neurons was recorded extracellularly on awake monkeys (macaca cynomolgus). striatal stimulation induces in subthalamic (sth) neurons a short latency spike discharge (10-15 msec) followed by a long lasting depression of the spontaneous activity. as, according to anatomical studies, the subthalamic nucleus is principally connected to the globus pallidus (gp), electrophysiological relations between striatal and gp neurons and bet ... | 1976 | 820409 |
| [nursing procedures for cynomolgus monkey infants (author's transl)]. | this paper describes the results of the artificial nursing of 8 infant cynomolgus monkeys (macaca fascicularis) weighing 230-350 g at birth. the infants were separated from their mothers just after or 2 days after birth and were kept in a specially deviced small cage (photo 1 & 2). they were fed on 6.4-16.6% solution of a commercially available powdered milk for the human baby. apple juice also was given to them from the 3rd or 4th week on. in about the 6th week, the infants received solid foods ... | 1976 | 820560 |
| [surface structure of the lips and tactile hairs of cynomolgus monkeys. scanning electron microscopic studies on the transitional part between the skin and mucosa 1]. | | 1976 | 821303 |
| applanation tonometry in the conscious cynomolgus monkey (macaca fascicularis). | four monkeys (macaca fascicularis) were trained to tolerate applanation tonometry while fully conscious. the tonometer used was the draeger tonometer with an applanation area of 3.06 diameter, but with a reduced application surface (4 mm instead of 6.8 mm diameter). the reduction did not change the calibration and is applicable in this monkey species without any correction factor. the mean intraocular pressure determined was 19.12 mmhg. | 1976 | 821306 |
| effect of bran and cholestyramine on plasma lipids in monkeys. | semipurified diets whose cholesterol content varied from 34 to 120 mg/100 kcal were given to adult female cynomolgus monkeys (macaca fascicularis) for 9 months. the intake of dietary fiber was increased through the addition of wheat, rice, or soya bran; 5% cholestyramine was given to one group of monkeys. none of the brans reduced plasma levels of cholesterol, whereas cholestyramine produced marked hypocholesterolemic effects. triglyceride levels increased with higher cholesterol intake, but no ... | 1976 | 821335 |
| proline-rich proteins in membranes and contents of monkey (macaca irus and cercopithecus aethiops) parotid zymogen granules. | | 1976 | 821460 |
| metabolism of 16,16-dimethyl-prostaglandin f2alpha in the cynomolgus monkey and the human female. | | 1976 | 821483 |
| identification, classification and anatomical segregation of cells with x-like and y-like properties in the lateral geniculate nucleus of old-world primates. | 1. all the cells (158) that we studied in the lateral geniculate nuclei of macaca nemestrina and macaca irus could be distinguished as either x-like or y-like on the basis of their responses to tests developed to classify cat retinal and lateral geniculate nucleus cells. these tests include responses to stationary spots, fast moving wands and moving gratings. 2. response latencies to electrical stimulation of the optic chiasm were determined for 130 cells; no x-like cell showed a latency shorter ... | 1976 | 822151 |
| disynaptic inhibition of spinal motoneurones from the motor cortex in the monkey. | 1. the neuronal mechanism of disynaptic inhibition of spinal motoneurones by the corticospinal tract was investigated in macaca irus. surface stimulation or weak intracortical stimulation was used in order to evoke the inhibition. intracellular records were taken from motoneurones in lumbar segments. 2. both the disynaptic i.p.s.p.s evoked from group ia afferents and the disynaptic i.p.s.p.s evoked from corticospinal fibres were found to be depressed by conditioning stimulation of motor axons to ... | 1976 | 822152 |
| histochemical and biochemical properties of the labial and palatine glands and their secretions in the macaca irus and cercopithecus aethiops monkeys. | the increasing use of non-human primates in experimental studies in dentistry demands detailed knowledge of their basic oral biology. the labial and palatine glands and their secretory products were compared in two commonly used monkey species. the mucous cells of both gland types appeared to elaborate sulphated muco-substances and the serous demilunes of the labial glands neutral mucosubstances. the secretions of these glands, as obtained by in vitro cultivation of glandular tissue were subject ... | 1976 | 822685 |
| influence of cataleptoid anaesthetic agents on the intraocular pressure in monkeys (macaca fascicularis). | trained monkeys which allowed a tonometry while conscious were used to test the influence of cataleptoid anaesthetics on intraocular pressure (iop). the drugs were injected intramuscularly in two dosages: with the lower dose (dt) it became just possible to perform a tonometry in untrained monkeys. the second dose (ds) induced surgical anaesthesia. the drugs used were: phencyclidine, dt: 0.6-0.7 mg/kg, ds: 1.2-1.4 mg/kg. ketamine, dt: 4-6 mg/kg, ds: 25 mg/kg. ci-744, a combination of a pure catal ... | 1976 | 822686 |
| effect of malnutrition on cortisol-binding protein in the lens of cynomolgus monkeys. | a cortisol-binding protein exists in the lens of cynomolgus monkeys as in other species. the cortisol-binding capacity decreased markedly with a diet either moderately or severely depleted of protein, even if the diet was later changed to a normal diet during infancy. this suggests that malnutrition may cause insufficient synthesis of the important factors controlling the inactivation of steroid hormone in the lens. | 1976 | 823312 |
| caesarean section in the java monkey (macaca irus)--a case report. | | 1976 | 823378 |
| histochemical studies on beta-glucuronidase activity in developing teeth and bone of rat and macaque monkey. | the enzyme beta-glucuronidase (e.c. 3.2.1.31.) has been studied in developing teeth and bone of sprague-dawley rats and macaque monkeys (macaca irus) by means of histochemistry using naphthol-as-bi-beta-d-glucuronide as substrate and hexazotized pararosanilin as coupling reagent. since beta-glucuronidase is sensitive to fixatives a freeze-sectioning technique has been used which made it possible to section highly mineralized tissues without previous fixation and decalcification. in the bone enzy ... | 1975 | 823790 |
| loss of acute pilocarpine effect on outflow facility following surgical disinsertion and retrodisplacement of the ciliary muscle from the scleral spur in the cynomolgus monkey. | an ab-interno goniotomy-like operation for disinserting the ciliary muscle from the scleral spur in cynomolgus monkeys is described. following postoperative miotic and corticosteroid treatment, the eyes did well clinically and the muscle reattached to the sclera posterior to the spur. outflow facility and intraocular pressure were mildly reduced. there was drainage of aqueous humor via the conventional outflow routes, and blood flow to the ciliary body. the outflow facility increasing effect of ... | 1976 | 824222 |
| effects of paracentesis on the blood-aqueous barrier: a light and electron microscopic study on cynomolgus monkey. | the effects of paracentesis on the blood-aqueous barrier of cynomolgus monekeys were studied by light and electron microscopy. the following regions of the eye were examined: ciliary body, iris, schlemm's canal, juxtacanalicular connective tissue, and trabecular meshwork. prominent structural alterations were seen in the ciliary epithelium at the anterior portion of the pars plicata, but the epithelium at the posterior portion of the pars plicata and at the pars plana appeared less disrupted. pl ... | 1976 | 824223 |
| priming of macaca cynomolgus philippinensis with purified antigen of brucella melitensis before injection of rev. i vaccine. | in experiments designed for study of bacteremia and serologic response of macaca cynomolgus philippinensis to vaccination with a soluble antigen (fraction i) of brucella melitensis and the live rev. i vaccine strain, fraction i and rev. i were administered both four weeks apart and simultaneously. one of three monkeys given the vaccines four weeks apart and two of three monkeys vaccinated with fraction i and rev. i in a single injection developed transient bacteremia, as shown by blood cultures. ... | 1976 | 824373 |
| oral glucose tolerance test in the cynomolgus monkey (macaca fascicularis). | the glucose tolerance test was simplified so that it could be performed on more than one cynomolgus monkey (macaca fascicularis) at a time. glucose was administered orally in a dose of 2 g/kg body weight as a 50% aqueous solution, and blood samples were taken just before and 30 minutes and 150 minutes after glucose administration. the simplified test was conducted on a total of 93 cynomolgus monkeys. glucose tolerance curves obtained by this method were classified into three patterns with regard ... | 1976 | 824499 |
| initial colonization of teeth in monkeys as related to diet. | the initial phases of plaque development on nonretentive tooth surfaces were studied bacteriologically in macaca irus monkeys fed by stomach tube and provided with various oral supplements. except for the oral implantation of streptococcus mutans in some of the animals, the oral flora was not changed prior to the studies. dental plaque was allowed to develop on initially cleaned tooth surfaces for 3 to 5 h. plaque samples were collected and cultured on a number of selective and nonselective agar ... | 1976 | 825462 |
| an outbreak of epistaxis in cynomolgus monkeys (macaca fascicularis). | | 1976 | 826008 |
| studies on the treponema pallidum immobilizing activity in normal human serum. 5. on the protective role against syphilis. | it was shown that t. pallidum immobilized in vitro by normal serum had lost its infectivity in rabbits. this finding suggested that the immobilizing activity of normal serum might play a role in the natural resistance of man against infections with t. pallidum. however, the results of serological studies of acquired early syphilis in man and of experimental syphilis in cynomolgus monkeys did not present evidence that the immobilizing activity of normal serum protected against syphilis infection. | 1976 | 826114 |
| effect of chemical modifications on the metabolic transformation of prostaglandins. | the metabolism of three analogues of pgf2alpha was studied in the cynomolgus monkey and in the human, viz., 15-methyl-pgf2alpha, 16,16-dimethyl pgf2alpha, and 17-phenyl-18,19,20-trinor-pgf2alpha. the half-lives of the three compounds in the human circulation was considerably longer than that of pgf2alpha. the dehydrogenation of the secondary alcohol group at c-15 was completely blocked in the two first-mentioned compounds. these were degraded mainly by beta-oxidation, and their main metabolites, ... | 1976 | 826142 |
| protrusions of the inner wall of schlemm's canal. | large specific protrusions of the trabecular meshwork into schlemm's canal (hernias) have been suggested to be the main drainage routes for aqueous humor, similar to the function of the arachnoid villi in draining the cerebrospinal fluid. my quantitative study in cynomolgus monkeys does not support such a hypothesis. the drainage routes of the aqueous humor, evaluated from the number and sizes of the pores observed by scanning electron microscopy, were as common through the hernias as through ot ... | 1976 | 826163 |
| blood groups of bonnet macaques (macaca radiata), with a brief introduction to seroprimatology. | the human-type a-b-o blood groups of 52 bonnet macaques (macaca radiata) were determined. application of method of population genetics indicated the gene frequences to be 0 = 0.173, a = 0.480 and b = 0.347. cross testing of sera and red cells of the bonnet macaques revealed two blood-type-specific isoagglutinins, one of them strong enough for use as a blood typing reagent. no blood group polymorphism was revealed by testing bonnet macaque red cells with isoantisera produced in rhesus monkeys (m. ... | 1976 | 826172 |
| influence of cholinergic receptor blockade on drug-induced prolactin release in the monkey. | the influence of varying doses of perphenazine, thyrotropin-releasing hormone (trh) and serotonin on prolactin release was examined in two species of monkeys: rhesus (macaca mulatta) and crab-eating (macaca fascicularis). the intravenous administration of 0.33 mg/kg body weight of perphenazine or 1.0 mug/kg body weight of trh gave a greater release of prolactin than higher doses of perphenazine (1.0 mg/kg) or trh) (3.4 mug/kg), respectively. prolactin release induced by serotonin at doses of 1, ... | 1976 | 826472 |
| [antifertility effect of an active immunization of monkeys with human pregnancy-specific beta 1-glycoprotein (sp1) (author's transl)]. | fertile female cynomolgus monkeys (macaca fascicularis) were actively immunized against human pregnancy-specific beta 1-glycoprotein (sp1). native sp1 as well as chemically modified derivatives of sp1 served as antigens. the effect of the immunization on reproduction in these animals was investigated. the immunized monkeys showed a significant reduction in fertility: the conception rate in these animals was only slightly reduced when compared with the controls; but in the immunized monkeys pregn ... | 1976 | 827272 |
| chemical composition of cynomolgus monkey milk. | milk samples from eight cynomolgus monkeys whose lactation period ranged 44-119 days were investigated for their gross chemical composition such as total solids, crude protein, lipids, lactose and ash. nitrogen distribution, compositions of fatty acids, amino acids and triglycerides as well as major minerals were also determined. these analytical data were compared with those reported for man, simian and cow, and cynomolgus monkey milk was found to have close similarities to human milk. | 1976 | 827449 |
| comparative study of the banding patterns of the chromosomes of cercopithecidae. i. subfamily papinae: macaca fascicularis and papio sphinx. | the diploid number of macaca fascicularis and papio sphinx is 42. all chromosomes are biarmed. using g-banding techniques, the complements of these two species have been compared. the topography of the bands is identical in all but one chromosome pair, showing a small pericentric inversion. the results indicate the existence of an extreme conservation in the arrangement of the genetic material and that changes at the gene level may have contributed to speciation in the papinae. | 1976 | 827484 |
| studies on pancreatic islet accumulation and cytotoxicity of n-nitrosomethylurea in the cynomolgus monkey. | | 1976 | 828134 |
| [experimental gingivitis by feeding soft food containing sucrose. repeated observation in a macaca irus monkey (author's transl)]. | | 1976 | 829780 |
| a ventral tract from the bed nucleus of the stria terminalis to the amygdaloid complex in the monkey (macaca fascicularis): possible pathway in the regulation of ovulation [proceedings]. | characteristics of a ventral tract from the bed nucleus of the stria terminalis (bst) to the amygdaloid complex in the monkey (macaca fascicularis) are described. a system of approximately 200 fiber bundles lying between the bst and baso-lateral part of the amygdaloid complex was identified and postulated to be monosynaptic. the bundles consist of unmyelinated fibers with a median diameter of .16-.20 mcm. no axons could be found with a diameter greater than .55 mcm, and 8% of the fibers had a ... | 1977 | 853388 |
| chromosomal abnormalities in lymphocytes from monkeys poisoned with lead. | cynomolgus monkeys (macaca irus) were given 0, 1.5, 6 or 15 mg of lead acetate 6 days a week for 16 months. another group, also receiving 6 mg, was kept on a low-calcium diet. each experimental group consisted of 2 monkeys. chromosome analysis on cultured lymphocytes was carried out after 3, 10 and 16 months of lead treatment. the frequency of severe abnormalities (dicentrics, rings, translocations and exchanges) was significantly increased only in the group on a low calcium diet, whereas "light ... | 1977 | 917037 |
| brugia timori: experimental infection in some laboratory animals. | experimental infection with brugia timori of 7 jirds (merionesunguiculatus), 4 cats and 2 monkeys (macaca fascicularis) is described. although no microfilariae were detected by examining 20 microliter samples of tail blood of jirds, adult worms were recovered from 6 of the 7 jirds at autopsy 69-141 days following infection. some worms were gravid and microfilariae were found in visceral blood of 2 animals. the adult recovery rate in jirds was 16%; the male to female ratio was 1:3. in cats patent ... | 1977 | 918709 |
| [bacteriolgical survey on bordetella bronchiseptica in various animal species (author's transl)]. | bordetella bronchiseptica was examined on the respiratory tract of mice, rats, mongolian gerbils, golden hamsters, guinea pigs, rabbits, household dogs and cats and cynomolgus monkeys imported from asian countries. the organisms were detected in rats, guinea pigs, rabbits, dogs, cats and monkeys, but not in mice, mongolian gerbils and golden hamsters. in rats, the organisms were isolated from 7 of 25 breeding colonies, and isolation rates ranged from 10.0 to 61.3% by colonies. in guinea pigs, 22 ... | 1976 | 944138 |
| dextran-induced anaphylactoid reactions in man: role of dextran reactive antibodies. | dextran reactive antibodies (dra) were studied in 123 patients having experienced dextran-induced anaphylactoid reactions (diar) during 1970-1975. no evidence for reaginic dra was obtained by radioallergosorbent technique and passive cutaneous anaphylaxis in cynomolgus monkeys; total ige levels were within normal range. it is concluded that diar are not mediated by dextran-specific reagins. further, no reaginic antibodies against potential contaminants from the dextran manufacturing process were ... | 1976 | 1017885 |
| production of ra27/3 rubella vaccine and clinical results with the vaccine. | adaptation of rubella virus to human diploid cell strains was achieved in 1964, with attenuation in the same cells being accomplished by 1967. the production of rubella vaccine in hdcs is featured by the long period required to build up high titer. high multiplicity of infection gives optimal results. since rubella virus does not produce a cytopathic effect in hdcs, virus harvests must be made blindly and titrated individually before pooling. a unique feature of this cell-virus relationship is t ... | 1976 | 1031691 |
| in vitro production of sulphated mucosubstances by the labial and palatine glands of the monkey macaca irus. | | 1975 | 1054577 |
| effects of triamcinolone acetonide on experimental oral candidiasis in monkeys. | thirteen adult monkeys (macaca irus) were infected with candida albicans by inoculating the microorganisms under an acrylic plate covering the palatal mucosa. six of the monkeys were treated with the steroid triamcinolone acetonide intramuscularly for 2 weeks before and 2 weeks after inoculation. the palatal mucosa was studied clinically and histologically at weekly or biweekly intervals for up to 5 months after inoculation. the cellular immune response was studied using the direct leukocyte mig ... | 1975 | 1056095 |
| prevention of streptococcus mutans infection of tooth surfaces by salivary antibody in irus monkeys (macaca fascicularis). | four irus monkeys (macaca fascicularis) were immunized with streptococcus mutans 6715 killed cells and cell products by injection in the vicinity of the major salivary glands and by instillation into the parotid glands via the ducts. after immune group and a sham-immunized control group of monkeys were infected orally with viable strain 6715 organisms. dental plaque samples were taken at intervals from the buccal and lingual grooves of the first permanent molars. these samples were evaluated for ... | 1975 | 1097337 |
| arterial fibrous proteins in cynomolgus monkeys after atherogenic and regression diets. | fibrous proteins were measured in five arterial beds in adult cynomolgus monkeys after administration of atherogenic and regression regimens. atherosclerosis was induced by feeding the monkeys a hypercholesterolemic diet containing 1.2% cholesterol for 17 months. a low-fat, cholesterol-free regression diet was then given for 60 days, 200 days, and 20 months. in atherosclerosis, collagen concentration (mg/g dry weight) and collagen content (mg/cm length of artery) both increased. at 200 days of r ... | 1975 | 1116235 |
| olfactory neuroepithelioma in a cynomolgus monkey (macaca fascicularis). | this is a report of an olfactory neuroepithelioma occurring in a male cynomolgus monkey (macaca fascicularis). it is not possible to state whether this tumor was spontaneous or related to the experimental procedures carried out in this animal. | 1975 | 1123841 |
| methacholine: a 7-day inhalation toxicity study with primates. | the acute and sub-acute inhalation toxicity of methacholine to cynomolgus monkeys was assessed by exposure of animals to an aerosol of a 2% solution of the material in sterile saline. the acute response was characterized by a decrease in tidal volume, increase in respiratory rate, a fall in dynamic compliance and an increased pulmonary resistance. onset of the acute response was rapid, reached a peak after 2-3 min of exposure and recovery appeared to be complete after 30 min following terminatio ... | 1975 | 1129803 |
| long-term exposure to sulfur dioxide, sulfuric acid mist, fly ash, and their mixtures. results of studies in monkeys and guinea pigs. | groups of cynomolgus monkeys and guinea pigs were exposed to mixtures of sulfur dioxide, fly ash, and sulfuric acid mist. the exposure concentrations varied between 0.1 and 5.0 ppm for sulfur dioxide, 0.1 and 1 mg/cu m for sulfuric acid mist, while a concentration of approximately 0.5 mg/cu m was used for fly ash. the duration of exposure was 52 weeks for guinea-pigs and 78 weeks for monkeys. pulmonary function tests and serum biochemical and hematological analyses were conducted prior to and pe ... | 1975 | 1130840 |
| estrogen and progesterone secretion in monkeys (macaca fascicularis) following melatonin or altschule's pineal extrac. | large doses (30mg) of melatonin given weekly to crab-eating monkeys throughout five menstrual cycles did not change the pattern of estrogen and progesterone secretion during the period of injection or in the two succeeding cycles. altschule's pineal extract, unlike melatonin, had no effect on estrogen or progesterone secretion during the period of injection or in the two succeeding cycles, when it was given daily between days 7 and 17 of the menstrual cycle. | 1975 | 1132533 |
| metabolism of 17-phenyl-18,19, 20-trinor-prostaglandin f2alpha in the cynomolgus monkey and the human female. | [9beta- -3h]-17-phenyl-18,19,20-trinor-pgf2alpha was injected subcutaneously into female cynomolgus monkeys and the structures of six products appearing in the urine were determined. the main urinary metabolites were the dinor- and tetranor-derivatives of 15-keto-13,14-dihydro-17-phenyl-18,19,20-trinor-pgf2alpha. unchanged 17-phenyl-18,19,20-trinor-pgf2alpha was also identified among the urinary products, as well as its dinor- and tetranor-derivatives. finally, the dinor-derivative of 13,14-dihy ... | 1975 | 1135425 |
| diet-induced aortic atherosclerosis in malaysian long-tailed monkeys (macaca irus). | moderate hypercholesterolaemia has been produced in eight adult male m. irus monkeys by feeding an egg-toast preparation containing butter and 0.14 per cent. total cholesterol. at autopsy, after two to four years of persistent hypercholesterolaemia, there was massive fatty streaking of the aorta involving 21 to 78 per cent. of the intimal surface. the distribution and morphology of the fatty streaks was similar to that in man. in addition, there were fibrous plaques including "soft" lipid-rich a ... | 1975 | 1151525 |
| a comparison of thermoregulatory responses in the japanese macaque (macca fuscata) and the crab-eating macaque (macaca irus) during cold exposure. | thermoregulatory responses in four male adult japanese macaques and four male adult crab-eating macaques, weighing 6-12 kg and 6.2-8 kg, respectively, were compared at ambient temperatures (ta) ranging from 5 degrees c to 25 degrees c. the average values +/- s.e. for some physiological measurements made at ta of 25 degrees c in the japanese macaque and the crab-eating macaque, respectively, were as follows: resting metabolic rate; 47.6 +/- 5.0 and 42.5 +/- 1.7 w/m2; tissue conductance; 11.9 +/- ... | 1975 | 1152303 |
| purification of zymogen granules from monkey parotid glands. | a method giving highly purified zymogen granules from macaca irus and cercopithecus aethiops parotid glands in reported. a 0.3 m sucrose medium for homogenization was supplemented with 10 mm tris/hcl, ph 7.3, and 0.1 mm lauric acid to stabilize the fragile monkey zymogen granules. nuclei and cell debris were sedimented at 150 times g. a "crude" zymogen granule fraction was trapped in the 1.0 m sucrose layer of a discontinuous sucrose gradient at 1000 times g. equilibrium centrifugation in a cont ... | 1975 | 1155105 |
| effect of administered human interferon on experimental rabies in monkeys. | cynomolgus monkeys infected with rabies virus were protected by repeated intramuscular administration of human leukocyte interferon beginning 24 h after infection. | 1975 | 1168171 |
| estrogen secretion and its relation to corpus luteum formation in monkeys (macaca fascicularis) given melatonin. | daily injection of 10 mg of melatonin from the 7th through the 17th day of the menstrual cycle in the crab-eating monkey delays the appearance of increased secretion of progesterone or prevents it altogether. in the cycles following melatonin treatment, the time in the cycle when the preovulatory estrogen rise occurs is more variable and the frequency of a second estrogen peak increases. | 1975 | 1169173 |
| effects of penfluridol and other drugs on apomorphine-induced stereotyped behavior in monkeys. | the effects of some drugs on apomorphine-induced stereotyped behavior were studied in male cynomolgus monkeys. apomorphine produced the dose-dependent stereotyped behavior characterized mainly by continuous licking and biting, and repetitive movements of the hands, head and body in the monkeys. penfluridol as well as haloperidol showed a clear antagonistic effect on the apomorphine-induced stereotyped behavior, while chlorpromazine was less antagonistic than haloperidol. the antagonistic effect ... | 1975 | 1171014 |