| morphological and genetic analysis of three bacteriophages of serratia marcescens isolated from environmental water. | increases in multidrug-resistant strains of serratia marcescens are of great concern in pediatrics, especially in neonatal intensive care units. in the search for bacteriophages to control infectious diseases caused by multidrug-resistant s. marcescens, three phages (ksp20, ksp90, and ksp100) were isolated from environmental water and were characterized morphologically and genetically. ksp20 and ksp90 belonged to morphotype a1 of the family myoviridae, and ksp100 belonged to morphotype c3 of the ... | 2009 | 19087204 |
| [an open study evaluating the efficacy and security of magnesium and vitamin b(6) as a treatment of tourette syndrome in children]. | we intended to ascertain the effectiveness and safety of oral solutions of magnesium and vitamin b(6) in alleviating the symptoms emerged during clinical exacerbations in children aged 7-14 years suffering from tourette syndrome (ts). we also aimed to determine the mean and the standard deviation of such an improvement in order to estimate sample sizes in future assays with a control group. | 2008 | 19087826 |
| a randomized cie l*a*b* evaluation of external bleaching therapy effects on fluorotic enamel stains. | to evaluate the effect of external bleaching on the color and luminosity of fluorotic stains and adjacent, normally mineralized enamel areas by means of cie l*a*b* colorimetry. | 2008 | 19088953 |
| response of rice advance line pb-95 to potassium application in saline-sodic soil. | a field experiment was conducted to evaluate the response of rice crop to potassium fertilization in saline-sodic soil during 2005. soil samples were collected before transplanting of rice crop and analysed for physical and chemical properties of the soil. in this experiment five rates of k2o (0, 25, 50, 75 and 100 kg ha(-1)) were applied in the presence of basal doses of n and p2o5 i.e., 110 and 90 kg ha(-1), respectively. whole of p, k and 1/2 of n were applied at the time of rice transplantin ... | 2007 | 19090203 |
| effect of marble industry effluent on seed germination, post germinative growth and productivity of zea mays l. | a green house study was conducted at the university of malakand, nwfp, pakistan to evaluate the effect of marble industry effluent on soil ph, germination, post germinative growth and productivity of maize. the experiment was conducted in triplicate form for each treatment and tape water was used as control (t0). effluents were diluted with tap water at concentration of 20% (t1), 40% (t2), 60% (t3), 80% (t4) and also used 100% (t5) concentration in 4 kg soil pot(-1) and plants were grown for 90 ... | 2007 | 19090297 |
| effects of long-term exposure to ramelteon, a melatonin receptor agonist, on endocrine function in adults with chronic insomnia. | to evaluate the effects of ramelteon, an mt(1)/mt(2) melatonin receptor agonist used to treat insomnia, on endocrine function in adults with chronic insomnia. | 2009 | 19090503 |
| fractures of the upper transthoracic cage. | we have reviewed our experience in managing 11 patients who sustained an indirect sternal fracture in combination with an upper thoracic spinal injury between 2003 and 2006. these fractures have previously been described as 'associated' fractures, but since the upper thorax is an anatomical entity composed of the upper thoracic spine, ribs and sternum joined together, we feel that the term 'fractures of the upper transthoracic cage' is a better description. these injuries are a challenge because ... | 2009 | 19092011 |
| prevalence and causes of undiagnosed hyperthyroidismin an adult healthy population. the tromsø study. | the causes of subclinical hyperthyroidism have only been reported from clinical studies. | 2008 | 19092288 |
| absence of thyrotropin-induced increase in leptin levels in patients with history of differentiated thyroid carcinoma undergoing recombinant human thyrotropin testing. | some extra-thyroid effects of tsh have been described in vitro and in vivo. tsh has recently been suggested to induce interleukin-6 secretion by adipocytes. leptin is the main protein secreted by adipose tissue. | 2008 | 19092294 |
| acanthamoeba t4 and t15 genotypes associated with keratitis infections in italy. | thus far there is little data available concerning acanthamoeba associated amoebic keratitis (ak) from italy. in order to understand the incidence of acanthamoeba in patients with ocular infections and to characterize the isolates at the molecular level, ocular specimens and contact lenses or lens case solutions from 140 patients were analysed by culture and by an 18s rrna (rns) gene-based pcr method. nineteen (13.6%) patients showed acanthamoeba culture positive samples. eleven out of the 14 ge ... | 2009 | 19093140 |
| effects of 18 months of l-t4 replacement in women with subclinical hypothyroidism. | some of the cardiovascular and renal abnormalities seen in overt hypothyroidism have also been reported in subclinical hypothyroidism (sch). short-term l-t4 replacement in sch improves cardiovascular risk markers and reduces carotid intima-media thickness (cimt), a surrogate marker of atherosclerosis. the haemodynamic and renal effects of l-t4 replacement in sch are poorly understood. | 2009 | 19094068 |
| the combination of low-dose levobupivacaine and fentanyl for spinal anaesthesia in ambulatory inguinal herniorrhaphy. | this study investigated whether the addition of 25 microg intrathecal fentanyl to levobupivacaine spinal anaesthesia for outpatient inguinal herniorrhaphy allows a sub-anaesthetic levobupivacaine dose to be used. forty patients were assigned to receive 5 mg levobupivacaine 0.5% mixed with 25 microg fentanyl (group lf) or 7.5 mg levobupivacaine 0.5% (group l). the highest sensory block levels achieved were t7 (range t5 - t9) and t6 (range t4 - t9) in groups lf and l, respectively. the times to tw ... | 2008 | 19094438 |
| [hypothyroidism and terminal renal failure in the neonatal period]. | it has been described alterations of the thyroid function in patients with chronic renal disease without primary disease of the thyroid gland. nevertheless primary hypothyroidism is more frequent in this population than in other non renal chronic disease. authors report two cases of hypothyroidism diagnosed in infants with terminal renal failure in the neonatal period, secondary to renal hypoplasia / dysplasia, both in peritoneal dialysis programme. the diagnosis was made by elevated value of th ... | 2008 | 19094814 |
| an experimental approach to the interrelationship between hyperthyroidism and ejaculation latency time in male rats. | we investigated the effects of experimentally induced hyperthyroidism on seminal vesicle pressure measurements and bulbospongiosus muscle contractile activity in a para-chloroamphetamine (sigma-aldrich) induced ejaculation model in rats. | 2009 | 19095256 |
| annual variations of quantitative eeg in patients with chronic epilepsy. | annual changes in powers of the close-eyed eeg were measured over 12 months in 12 patients with epilepsy. | 2008 | 19095583 |
| staging of t3 and t4 gastric carcinoma with multidetector ct: added value of multiplanar reformations for prediction of adjacent organ invasion. | to determine the added value of multiplanar reformation (mpr) images combined with computed tomographic (ct) images in staging of t4 gastric cancers. | 2009 | 19095785 |
| a randomized trial of maximum cephalad sensory blockade with single-shot spinal compared with combined spinal-epidural techniques for cesarean delivery. | previous studies have shown more extensive cephalad sensory blockade in women receiving combined spinal-epidural (cse) anesthesia compared with single-shot spinal (sss) anesthesia for elective cesarean delivery. it has been postulated that introduction of the epidural needle during cse disturbs the negative pressure in the epidural space, resulting in relatively greater cerebrospinal fluid (csf) pressure and increased spread of intrathecal local anesthetic. we tested the hypothesis that cse resu ... | 2009 | 19095857 |
| circulating cell-free dna in plasma of locally advanced rectal cancer patients undergoing preoperative chemoradiation: a potential diagnostic tool for therapy monitoring. | circulating cell-free dna opens up an interesting field for therapy monitoring, in particular during multimodal therapy protocols. the objective of this proof of principle study was to evaluate whether the amount of circulating plasma dna has the potential to serve as a marker for therapy monitoring during the treatment course of locally advanced rectal cancer patients. we especially focused on kinetics of circulating dna to assess whether variances in kinetics have the potential to discriminate ... | 2008 | 19096128 |
| survival after trimodality treatment for superior sulcus and central t4 non-small cell lung cancer. | for sulcus superior tumors and central ct4 tumors, low resectability and poor long-term survival rates are obtained with single-modality treatment. | 2009 | 19096308 |
| the port site recurrence after a thoracoscopic and video-assisted esophagectomy for advanced esophageal cancer. | thoracoscopic or video-assisted thoracic esophagectomies have been performed for the last 10 years. nevertheless, some reports have showed a risk of dissemination with endoscopic or video-assisted surgery for malignant disease. this institute experienced three cases of port site recurrence after a thoracoscopic esophagectomy for advanced esophageal cancer. following those cases, induction chemo-radiation therapy was performed for patient with advanced esophageal cancer before thoracoscopic or vi ... | 2009 | 19096321 |
| spontaneous spinal epidural hematoma in an infant : a case report and review of the literature. | spontaneous spinal epidural hematoma (sseh) is rare in children, especially in infants, in whom only 12 cases have been reported. because of the nonspecificity of presenting symptoms in children, the diagnosis may be delayed. we report herein a case of sseh in a 20-month-old girl who initially presented with neck pain, and developed lower extremity motor weakness and symptoms of neurogenic bladder 2 weeks prior to admission. the magnetic resonance imaging showed an epidural mass lesion extending ... | 2008 | 19096698 |
| propofol infusion shortens and attenuates oxidative stress during one lung ventilation. | resuming two lung ventilation (2lv) from one lung ventilation (olv) has been proven to induce significant oxidative stress, mainly by superoxide release. although total intravenous anesthesia and inhalational anesthesia are both used in thoracic surgery, different anesthetics may alter the oxidant/antioxidant balance. | 2008 | 19097962 |
| neurological impairment following myocardial ischemia associated with postoperative epidural analgesia. | although epidural analgesia reduces the postoperative stress response and provides good pain relief for patients, potential complications associated with the technique may decrease its acceptability for some patients. we describe a 76-year-old female who underwent surgery for carcinoma of the urinary tract. postoperative epidural analgesia was performed at the postanesthesia care unit. neither a repeat attempt nor accidental dural puncture was encountered during the procedure. unfortunately, she ... | 2008 | 19097969 |
| impact of microenvironment on the growth of primary human epidermal cells. | although the conditions for in vitro cultivation of adult stem cells and tissue are easily standardized, little is known about the optimal conditions for biointegration after transfer of the tissue graft, playing an important role in the treatment of defects especially soft-tissue skin injuries. to examine the influence of the microenvironment, we investigated the doubling time of primary epithelial cells in relation to the culture medium. serum from patients of different age groups (n = 15, <20 ... | 2008 | 19098543 |
| effect of low density lipoprotein on the quality of cryopreserved dog semen. | egg yolk is included in extenders for semen cryopreservation due to its protective effect against cold shock, which is attributed to the presence of low density lipoprotein (ldl). this study evaluates how semen quality is affected by using ldl as a replacement for egg yolk in extenders for cooled and frozen dog semen. in experiment 1, semen was extended in tris-glucose at 5 degrees c, in four treatments: 20% egg yolk (t1); 6% (t2); 8% (t3); and 10% ldl (t4). sperm motility and membrane integrity ... | 2009 | 19100690 |
| the frequency of autoimmune thyroid disorders in juvenile idiopathic arthritis. | few studies have been performed to investigate autoimmune diseases associated with organ non-specific rheumatological disorders in children, such as juvenile idiopathic arthritis (ia). the objective in this study was to determine the frequency of autoimmune diseases of the thyroid gland in children with jia. eighty patients with jia and 81 healthy sex- and age-matched controls were enrolled in the study. serum free t3, free t4, thyroid stimulating hormone (tsh), anti-thyroglobulin antibodies, an ... | 2008 | 19102051 |
| [toxic nodular goiter]. | to date no study in our country was specifically dedicated on toxic nodular goiter. they were just mentioned in generally studies about hyperthyroidism. | 2007 | 19102108 |
| salivary alpha amylase levels under conditions of extreme examination stress. | 11 healthy adult graduate students were studied on two separate occasions 2 wk. apart at the same time of day. self-rating of perceived stress and serial measurements of salivary alpha-amylase levels were performed at t1 = 15 min. before, t2 = 1 min. before, t3 = 1 min. after, and t4 = 15 min. after an event. the events were a highly stressful master's degree oral examination on the first occasion and 15 min. of typing on a computer on the second occasion as a control activity. a kinetic assay w ... | 2008 | 19102470 |
| [expressions of mmp-2 and cox-2 mrna in bladder transitional cell carcinoma and their correlation]. | to determine the levels of mmp-2 and cox-2 mrna in bladder transitional cell carcinoma tissues and explore their relationship. | 2008 | 19102503 |
| [our experiences of preoperative chemo-radiotherapy for t4 primary rectal cancer]. | we reviewed 7 cases of clinical record with preoperative chemo-radiotherapy to evaluate the clinical effectiveness of the chemo-radiotherapy for t4 rectal cancer. the preoperative radiation therapy consisted of 40-45 gy delivered in fractions of 1.8-2.0 gy per day, five days a week. a treatment of 5-fluorouracil, 500 mg/body per day intravenously, or oral uft-e (300 mg/m2) with l-leucovorin (75 mg) per day, or oral s-1 (80 mg/m2) per day five days a week, was given during radiotherapy. grade 1 o ... | 2008 | 19106509 |
| [two cases of advanced gastric cancer with postoperative severe complications after neo-adjuvant chemotherapy]. | we report two cases of advanced gastric cancer with severe postoperative complications after neo-adjuvant chemotherapy (nac). the first case is a 60-year-old man who was diagnosed as a type 2 advanced gastric cancer with paraaortic lymph node metastases and the elevation of serum ca19-9 level. nac was started, but no reductions were noted after 3 courses. palliative total gastrectomy with distal pancreatectomy, splenectomy, cholecystectomy, and partial hepatectomy for t4 gastric cancer exhibitin ... | 2008 | 19106528 |
| [s-1+gemcitabine (gem) therapy was effective in a case of unresectable pancreatic head carcinoma]. | treatment results of pancreatic head carcinoma are not good and long-term survival, especially in nonresectable cases is extremely difficult to obtain. the case reported here is of nonresectable pancreatic head carcinoma in which s-1+gemcitabine (gem) proved to be effective. | 2008 | 19106543 |
| [clinical study on multi-segmental pedicle screw implantation in the treatment of middle-upper thoracic spine fracture and dislocation]. | to review a group of clinical data of pedicle screw implantation in the treatment of middle-upper thoracic fracture and dislocation and explore these clinical effect. | 2008 | 19108376 |
| a general and efficient method for the site-specific dual-labeling of proteins for single molecule fluorescence resonance energy transfer. | a general strategy for the site-specific dual-labeling of proteins for single-molecule fluorescence resonance energy transfer is presented. a genetically encoded unnatural ketone amino acid was labeled with a hydroxylamine-containing fluorophore with high yield (>95%) and specificity. this methodology was used to construct dual-labeled t4 lysozyme variants, allowing the study of t4 lysozyme folding at single-molecule resolution. the presented strategy is anticipated to expand the scope of single ... | 2008 | 19108697 |
| bioequivalence of two levothyroxine tablet formulations without and with mathematical adjustment for basal thyroxine levels in healthy argentinian volunteers: a single-dose, randomized, open-label, crossover study. | levothyroxine has a narrow therapeutic index; therefore, precise and accurate assessment of the bioequivalence of different levothyroxine products is critical. bioavailability estimates of levothyroxine formulations might be affected by baseline concentrations of the hormone. | 2008 | 19108789 |
| polychlorinated biphenyls and thyroid hormones in adults: a systematic review appraisal of epidemiological studies. | reported evidence regarding relationships between polychlorinated biphenyls (pcbs) and thyroid homeostasis in adults has been considered contradictory. the objective of this systematic review is to determine a possible association between pcb exposure and the circulating thyroid hormones and thyrotropin (tsh) levels in adults, by analyzing the quality of published studies. a systematic review of epidemiological papers was conducted using pubmed. an evaluation of the quality of 22 studies was per ... | 2009 | 19108870 |
| a charged performance by gp17 in viral packaging. | packaging of viral genomes into virus capsids requires powerful motors to overcome the repulsive force that builds as the nucleic acids are compressed. through structural analyses of the t4 bacteriophage packaging motor gp17, sun et al. (2008) now propose a packaging mechanism in which electrostatic forces cause the motor to alternate between tensed and relaxed conformational states. | 2008 | 19109888 |
| the structure of the phage t4 dna packaging motor suggests a mechanism dependent on electrostatic forces. | viral genomes are packaged into "procapsids" by powerful molecular motors. we report the crystal structure of the dna packaging motor protein, gene product 17 (gp17), in bacteriophage t4. the structure consists of an n-terminal atpase domain, which provides energy for compacting dna, and a c-terminal nuclease domain, which terminates packaging. we show that another function of the c-terminal domain is to translocate the genome into the procapsid. the two domains are in close contact in the cryst ... | 2008 | 19109896 |
| the role of thyroid hormone in the pathophysiology of heart failure: clinical evidence. | thyroid hormone (th) has a fundamental role in cardiovascular homeostasis in both physiological and pathological conditions, influencing cardiac contractility, heart rate (hr), diastolic function and systemic vascular resistance (svr) through genomic and non-genomic mediated effects. in heart failure (hf) the main alteration of thyroid function is referred to as "low-triiodothyronine (t3) syndrome" (lt3s) characterized by decreased total serum t3 and free t3 (ft3) with normal levels of thyroxine ... | 2010 | 19110971 |
| severe rhabdomyolysis and acute renal failure secondary to use of simvastatin in undiagnosed hypothyroidism. | a 52-year-old indian woman with underlying diabetes mellitus and hyperlipidemia, presented with generalized musculoskeletal pain and oliguria for three days. the patient was taking 80 mg of simvastatin initiated 20 days earlier after cardiac catheterization for an inferior myocardial infarction. laboratory investigations revealed the following serum levels: creatine kinase 81,620 u/l, aspartate aminotransferase 2497 u/l, alanine aminotransferase 1304 u/l, blood urea nitrogen 21.7 mmol/l, creatin ... | 2009 | 19112232 |
| local lattice distortion in the giant negative thermal expansion material mn3cu1-xgexn. | giant negative thermal expansion is achieved in antiperovskite manganese nitrides when the sharp volume change associated with magnetic ordering is broadened by substitution. in this letter, we address the unique role of the ''magic" element, ge, for such broadening in mn3cu1-xgexn. we present evidence for a local lattice distortion well described by the low-temperature tetragonal (t4) structure of mn3gen for a range of x, where the overall structure remains cubic. this structural instability sh ... | 2008 | 19113356 |
| free t4 immunoassays are flawed during pregnancy. | the purpose of this study was to evaluate the diagnostic accuracies of 2 free thyroxine immunoassays during pregnancy. | 2009 | 19114271 |
| effects of early vital capacity maneuver on respiratory variables during multivessel off-pump coronary artery bypass graft surgery. | despite avoiding cardiopulmonary bypass, similar degrees of pulmonary impairment compared with on-pump coronary artery bypass surgery have been demonstrated in patients undergoing off-pump coronary artery bypass graft surgery (opcab) compared with on-pump coronary artery bypass surgery. to investigate the effects of an early vital capacity maneuver (vcm) on intrapulmonary shunt (qs/qt), oxygenation, and pulmonary outcome in opcab. | 2009 | 19114907 |
| role of the botrytis cinerea fkbp12 ortholog in pathogenic development and in sulfur regulation. | the functional characterization of the fkbp12 encoding gene from the phytopathogenic fungus botrytis cinerea was carried out. b. cinerea genome sequence owns a single ortholog, named bcfkbp12, encoding a fk506-binding protein of 12kda. bcfkbp12 mediates rapamycin sensitivity both in b. cinerea and in saccharomyces cerevisiae, a property unique to fkbp12 proteins, probably via the inhibition of the protein kinase tor (target of rapamycin). the relative abundance of the prolyl isomerase appeared t ... | 2009 | 19116175 |
| a phase ii study of synchronous three-dimensional conformal boost to the gross tumor volume for patients with unresectable stage iii non-small-cell lung cancer: results of korean radiation oncology group 0301 study. | we evaluated the efficacy of synchronous three-dimensional (3d) conformal boost to the gross tumor volume (gtv) in concurrent chemoradiotherapy for patients with locally advanced non-small-cell lung cancer (nsclc). | 2009 | 19117690 |
| the immediate effects of upper thoracic translatoric spinal manipulation on cervical pain and range of motion: a randomized clinical trial. | this study examined the effect of translatoric spinal manipulation (tsm) on cervical pain and cervical active motion restriction when applied to upper thoracic (t1-t4) segments. active cervical rotation range of motion was measured re- and post-intervention with a cervical inclinometer (crom), and cervical pain status was monitored before and after manipulation with a faces pain scale. study participants included a sample of convenience that included 32 patients referred to physical therapy with ... | 2008 | 19119394 |
| l-type amino-acid transporter 1 as a novel biomarker for high-grade malignancy in prostate cancer. | to find reliable biomarkers for high-grade malignancy, the relationship between immunohistochemical l-type amino-acid transporter 1 (lat1) expression of biopsy samples, determined with the newly developed monoclonal antibody against human lat1, and prognosis of patients with prostate cancer, was investigated. the intensity and score of immunohistochemical lat1 expression of first biopsy samples were assessed using the modified sinicrope et al. method and were found to be correlated with poor sur ... | 2009 | 19121087 |
| the effect of volatile anaesthetics on the relative sensitivity of facial and distal thoracic limb muscles to vecuronium in dogs. | to compare n. facialis-m. nasolabialis (nf-mnl) and n. ulnar-mm. carpi flexorii (nu-mcf) sensitivity to vecuronium during halothane or isoflurane anaesthesia. | 2009 | 19121159 |
| concerted effects of two activator modules on the group i ribozyme reaction. | group i intron ribozymes have a modular architecture and structural elements essential for catalysis. the elements are located in the conserved modular domain p3-p7 that is stabilized by another conserved module, p4-p6. it has been reported that artificial modules can complement the function of the native p4-p6. to exploit the modular architecture of group i ribozyme, we have constructed a hybrid ribozyme by attaching an artificial activator module to the wild-type t4 td ribozyme. kinetic analys ... | 2009 | 19122204 |
| clinical significance of extrathyroid extension to the parathyroid gland of papillary thyroid carcinoma. | extrathyroid extension is a prominent prognostic factor of papillary thyroid carcinoma (ptc). in the uicc tnm classification, minimal extension to the sternothyroid muscle and perithyroid soft tissue is classified as t3 and further massive extension is classified as t4, the highest t grade. however, there have been few studies on the clinical significance of extension to the parathyroid gland in a large case series. in this study, we investigated the prognosis of ptc with extension to the parath ... | 2009 | 19122348 |
| chaperonin complex with a newly folded protein encapsulated in the folding chamber. | a subset of essential cellular proteins requires the assistance of chaperonins (in escherichia coli, groel and groes), double-ring complexes in which the two rings act alternately to bind, encapsulate and fold a wide range of nascent or stress-denatured proteins. this process starts by the trapping of a substrate protein on hydrophobic surfaces in the central cavity of a groel ring. then, binding of atp and co-chaperonin groes to that ring ejects the non-native protein from its binding sites, th ... | 2009 | 19122642 |
| use of diode laser 980 nm as adjunctive therapy in the treatment of chronic periodontitis. a randomized controlled clinical trial. | the primary goal of periodontal therapy is the removal of supra and subgingival bacterial deposits by mechanical debridement consisting in scaling and root-planing (srp) using manual or power-driven instruments. the complete removal of bacteria and their toxins from periodontal pockets is not always achieved with conventional mechanical treatment. the use of lasers as an adjunctive therapy for periodontal disease may improve tissue healing by bactericidal and detoxification effects. the aim of t ... | 2008 | 19123307 |
| [effects of different irrigation treatments on photosynthesis of tieguanyin tea plants]. | by using chlorophyll fluorescence kinetics technique, the effects of different irrigation intervals, i.e., 5 d (t1), 10 d (t2), 15 d (t3), 20 d (t4), and 25 d (t5), on the photosynthesis of 2-year tieguanyin tea plants were investigated in the field, with no irrigation as the control. the results showed that the leaf water potential and chlorophyll content decreased with increasing irrigation interval, while the net photosynthesis (p) increased first and decreased then, reaching its highest valu ... | 2008 | 19123345 |
| enzymatic mechanism of human apurinic/apyrimidinic endonuclease against a thf ap site model substrate. | the endonucleolytic activity of human apurinic/apyrimidinic endonuclease (ap endo) is a major factor in the maintenance of the integrity of the human genome. there are estimates that this enzyme is responsible for eliminating as many as 10(5) potentially mutagenic and genotoxic lesions from the genome of each cell every day. furthermore, inhibition of ap endonuclease may be effective in decreasing the dose requirements of chemotherapeutics used in the treatment of cancer as well as other disease ... | 2009 | 19123919 |
| cardiac hypertrophy and thyroid hormone signaling. | thyroid hormone exerts a large number of influences on the cardiovascular system. increased thyroid hormone action increases the force and speed of systolic contraction and the speed of diastolic relaxation and these are largely beneficial effects. furthermore, thyroid hormone has marked electrophysiological effects increasing heart rate and the propensity for atrial fibrillation and these effects are largely mal-adaptive. in addition, thyroid hormone markedly increases cardiac angiogenesis and ... | 2010 | 19125327 |
| host-parasite relations of bacteria and phages can be unveiled by oligostickiness, a measure of relaxed sequence similarity. | motivation: the recent metagenome analysis has been producing a large number of host-unassigned viruses. although assigning viruses to their hosts is basically important not only for virology but also for prevention of epidemic, it has been a laborious and difficult task to date. the only effective method for this purpose has been to find them in a same microscopic view. now, we tried a computational approach based on genome sequences of bacteria and phages, introducing a physicochemical paramet ... | 2009 | 19126576 |
| sympathetic skin responses evoked by different stimuli modalities in spinal cord injury patients. | by using a combination of physiological and electrical peripheral nerve stimuli, the authors aimed to characterize the expected dysfunction of the circuits responsible for sympathetic skin response (ssr) in persons with spinal cord injury (sci). | 2009 | 19126837 |
| ossification of the thoracic ligamentum flavum in an achondroplastic patient: a case report. | we report a case of spinal stenosis with ossification of the thoracic ligamentum flavum in a 53-year-old man with achondroplasia. neurological signs indicated flaccid paralysis below l1, and the patient was unable to walk. ossification of the ligamentum flavum was observed at t4/5 and t9 to t12, compressing the thecal sac. laminectomy of t9 to l1 was performed. at one-year follow-up, the patient was able to walk with one elbow crutch. | 2008 | 19126915 |
| three-dimensional classification of thoracic scoliotic curves. | three-dimensional (3d) characterization of the thoracic scoliotic spine (cross-sectional study). | 2009 | 19127167 |
| neck dissection following concurrent chemoradiation for advanced head and neck carcinoma: pathologic findings and complications. | to assess the rate of pathologic residual neck disease and complication rates following selective neck dissection in patients with advanced head and neck carcinoma after concurrent chemotherapy (ct) and radiation therapy (rt). | 2008 | 19128575 |
| [influence of maternal hypothyroxinaemia during pregnancy on psychomotor development]. | the maternal thyroid function during early pregnancy plays a fundamental role in foetal brain development as synthesis of thyroid hormone does not begin until the 20th week of gestation. | 2008 | 19128742 |
| vertebral fracture assessment in moroccan women: prevalence and risk factors. | vertebral fracture assessment (vfa) is a fast, low-radiation technique which produces images that are of sufficient quality to be used to diagnose the presence of vertebral deformity consistent with fracture. | 2009 | 19128904 |
| spontaneous spinal epidural hematoma: a case report and literature review. | background: spontaneous spinal epidural hematoma (sseh) is a rare cause of spinal cord compression that requires emergency investigation and treatment. prompt diagnosis is essential to prevent morbidity and mortality. objectives: our goal was to report a case of sseh, and to review the literature on the topic, looking particularly at the factors influencing post-operative outcome, and the symptoms and signs that would lead one to consider this rare diagnosis. case report: a 36-year-old man prese ... | 2009 | 19128914 |
| phase ii trial of neoadjuvant docetaxel and gefitinib followed by radical prostatectomy in patients with high-risk, locally advanced prostate cancer. | prostate cancer trials investigating neoadjuvant hormonal therapy, followed by surgery, have demonstrated that elimination of all tumor cells from the primary site is rare. the authors report a phase 2 trial assessing the efficacy and toxicity of docetaxel and gefitinib in patients with high-risk localized prostate cancer as neoadjuvant therapy before radical prostatectomy (rp). | 2009 | 19130458 |
| cetuximab in combination with capecitabine, irinotecan, and radiotherapy for patients with locally advanced rectal cancer: results of a phase ii margit trial. | to evaluate the safety and efficacy of preoperative radiotherapy (rt) in combination with cetuximab, capecitabine, and irinotecan in patients with locally advanced rectal cancer. | 2009 | 19131187 |
| surgical treatment of lung cancer invading the left atrium or base of the pulmonary vein. | the purpose of the present study was to explore the efficacy of an extended operation for locally advanced non-small cell lung cancer invading the left atrium and intrapericardial pulmonary vein. | 2009 | 19132442 |
| toward understanding the conformational dynamics of rna ligation. | members of the genus trypanosoma, which include the pathogenic species trypanosoma brucei and trypanosoma cruzi, edit their post-transcriptional mitochondrial rna via a multiprotein complex called the editosome. in t. brucei, the rna is nicked prior to uridylate insertion and deletion. following editing, nicked rna is religated by one of two rna-editing ligases (tbrel). this study describes a recent 70 ns molecular dynamics simulation of tbrel1, an atp-dependent rna-editing ligase of the nucleot ... | 2009 | 19133737 |
| does sports participation during adolescence prevent later alcohol, tobacco and cannabis use? | to study whether participation in organized sports during adolescence predicts increased smoking of tobacco, alcohol intoxication and cannabis use from late adolescence to adulthood when controlling for potential confounders. moreover, to study whether such increased drug use varies according to type of sport (team versus individual), main skills needed (endurance, strength or technical) and level of competition. | 2009 | 19133899 |
| [compare of laparoscopic and open surgery for radical cystectomy with orthotopic ileal neobladder]. | to compare the clinical therapeutic effect and complications of laparoscopic radical cystectomy with orthotopic ileal neobladder (lrc-inb) with open radical cystectomy with orthotopic ileal neobladder (orc-inb). | 2008 | 19134373 |
| spinal deformity index (sdi) is a good predictor of incident vertebral fractures. | the spinal deformity index is a convenient tool to quantify the number and the severity of prevalent vertebral fractures. it is a predictor of the risk of sustaining incident vertebral fracture. this quantification must be taken into account to improve management of patients. | 2009 | 19137350 |
| influence of isoflurane general anesthesia or anesthesia and surgery on thyroid function tests in dogs. | anesthesia and surgery affect thyroid function tests in humans but have not been studied in dogs. | 2009 | 19138380 |
| histopathological and biochemical effects of green tea and/or licorice aqueous extracts on thyroid functions in male albino rats intoxicated with dimethylnitrosamine. | abstract: | 2009 | 19138393 |
| in vitro and in vivo production and purification of circular rna aptamer. | rna aptamers are potential candidates for rna therapeutics. they must be clinically modified for medical applications because they are vulnerable to indigenous ribonucleases. since circular rna molecules without any chemical modification are much more stable than linear ones in a cell extract, we report the production of a circular form of streptavidin rna aptamer both in vitro and in vivo. circularization was accomplished by self-splicing permuted intron-exon sequences derived from t4 bacteriop ... | 2009 | 19138712 |
| impact of organic solvents and environmental pollutants on the physiological function in petrol filling workers. | long term exposure to solvents and air pollutants can lead to deleterious effects on respiratory, haematological and thyroid functioning. the aim of this study was to investigate whether chronic exposure to solvents like benzene and pollutants like carbon monoxide in petrol filling workers had adverse effect on blood parameters, thyroid and respiratory functions. the study group consisted of 42 healthy, non-smoker petrol filling workers, aged 20-50 years with work (exposure) duration from 2-15 y ... | 2008 | 19139531 |
| preoperative administration of excess iodide increases thyroid volume of patients with graves' disease. | preoperative excess iodide administration for patients with graves' disease has been widely adopted by surgeons to perform surgery safely, because it decreases blood flow in the thyroid. however, surgeons often encounter the enlargement of thyroid volume after iodide administration, which makes surgery even more difficult. in this study, we retrospectively investigated the change in thyroid volume in graves' disease that was evaluated on ultrasonography between before and after iodide administra ... | 2009 | 19139595 |
| effects of protein microstructure on the retention time of t4 lysozyme variants in cation exchange chromatography. | the structure of a protein directly affects its function. therefore, characterization of recombinant protein structures is important but is a challenging task. one of the important forces that play a major role in maintaining both structural and functional properties of proteins is electrostatic interactions among different amino acid residues. in this article, cation exchange chromatography was used to study how the microstructure of some charged amino acid residues may affect a protein's reten ... | 2009 | 19140777 |
| cardiovascular parameters and liver blood flow after infusion of a colloid solution and epidural administration of ropivacaine 0.75%: the influence of age and level of analgesia. | lumbar epidural anaesthesia induces cardiovascular changes and decreases liver blood flow (qh). we studied the effects of age on haemodynamics, blood volumes and qh before and after epidural anaesthesia. | 2009 | 19142093 |
| [the iaslc lung cancer staging project. comparing the current 6(th) tnm edition with the proposed 7(th) edition]. | the future 7th edition of tnm classification for lung cancer will be published in 2009 and comprises the iaslc recommendations for tnm parameters. the general staging of lung cancer includes the new parameters: reclassification of tumours larger than 7 cm from t2 to t3; extra tumoral nodules will change their category to t3, t4 and m1 when in the same, ipsilateral or contralateral lobe, respectively; pleural effusion will be m1a. with these alterations, cases staged as ib - t2b n0 m0 will be iia ... | 2009 | 19145388 |
| computations of standard binding free energies with molecular dynamics simulations. | an increasing number of studies have reported computations of the standard (absolute) binding free energy of small ligands to proteins using molecular dynamics (md) simulations and explicit solvent molecules that are in good agreement with experiments. this encouraging progress suggests that physics-based approaches hold the promise of making important contributions to the process of drug discovery and optimization in the near future. two types of approaches are principally used to compute bindi ... | 2009 | 19146384 |
| intraspinal sprouting of unmyelinated pelvic afferents after complete spinal cord injury is correlated with autonomic dysreflexia induced by visceral pain. | autonomic dysreflexia is a potentially life-threatening hypertensive syndrome following high thoracic (t) spinal cord injury (sci). it is commonly triggered by noxious pelvic stimuli below the injury site that correlates with increased sprouting of primary afferent c-fibers into the lumbosacral (l/s) spinal cord. we have recently demonstrated that injury-induced plasticity of (l/s) propriospinal neurons, which relay pelvic visceral sensations to thoracolumbar sympathetic preganglionic neurons, i ... | 2009 | 19146928 |
| do bone marrow isolated tumor cells influence long-term survival of non-small cell lung cancer? | inconsistent information on the prognostic significance of non-small cell lung cancer (nsclc) isolated tumor cells (itc) has been reported to date. we sought to evaluate the survival for nsclc in a group of patients in which the presence of bone marrow isolated tumor cells and their dna ploidy was assessed. | 2009 | 19150243 |
| unavoidable mastectomy for ipsilateral breast tumour recurrence after conservative surgery: patient outcome. | in the case of ipsilateral breast tumour recurrence (ibtr) after breast-conserving surgery (bcs), a second conservative surgical approach maybe considered in some motivated patients whereas in others mastectomy is unavoidable. | 2009 | 19150942 |
| mitochondrial dna haplogroups associated with age-related macular degeneration. | to examine the mtdna control regions in normal and age-related macular degeneration (amd) retinas. to identify the mtdna variations associated with amd. | 2009 | 19151382 |
| spinal cord injury reduces the efficacy of pseudorabies virus labeling of sympathetic preganglionic neurons. | the retrograde transsynaptic tracer pseudorabies virus (prv) is used as a marker for synaptic connectivity in the spinal cord. using prv, we sought to document putative synaptic plasticity below a high thoracic (t) spinal cord transection. this lesion has been linked to the development of a number of debilitating conditions, including autonomic dysreflexia. two weeks after injury, complete t4-transected and/or t4-hemisected and sham rats were injected with prv-expressing enhanced green fluoresce ... | 2009 | 19151624 |
| physical exercise increases mitochondrial function and reduces oxidative damage in skeletal muscle. | the present study investigated mitochondrial adaptations and oxidative damage after 4 and 8 weeks of running training in skeletal muscle of mice. twenty-one male mice (cf1, 30-35 g) were distributed into the following groups (n = 7): untrained (ut); trained-4 weeks (t4); trained-8 weeks (t8). forty-eight hours after the last training session the animals were killed by decapitation and quadriceps (red portion) were removed and stored at -70 degrees c. succinate dehydrogenase (sdh), complexes i, i ... | 2009 | 19153761 |
| processive and unidirectional translocation of monomeric uvsw helicase on single-stranded dna. | uvsw protein from bacteriophage t4 controls the transition from origin-dependent to origin-independent initiation of replication through the unwinding of r-loops bound to the t4 origins of replication. uvsw has also been implicated through genetic and biochemical experiments to play a role in dna repair processes such as replication fork regression and holliday junction branch migration. uvsw is capable of unwinding a wide variety of substrates, many of which contain only duplex dna without sing ... | 2009 | 19154117 |
| the effect of bacteriophages t4 and hap1 on in vitro melanoma migration. | the antibacterial activity of bacteriophages has been described rather well. however, knowledge about the direct interactions of bacteriophages with mammalian organisms and their other, i.e. non-antibacterial, activities in mammalian systems is quite scarce. it must be emphasised that bacteriophages are natural parasites of bacteria, which in turn are parasites or symbionts of mammals (including humans). bacteriophages are constantly present in mammalian bodies and the environment in great amoun ... | 2009 | 19154575 |
| the applicability of the proposed iaslc staging revisions to small cell lung cancer (sclc) with comparison to the current uicc 6th tnm edition. | we examined the impact of the proposed internal association for the study of lung cancer (iaslc) tumor, node, metastasis (tnm) and stage grouping revisions on staging and survival outcome of small cell lung cancer (sclc). | 2009 | 19156001 |
| mode of lymphadenectomy and surgical outcome of upper thoracic esophageal squamous cell carcinoma. | only a few studies have evaluated the impact of clinicopathological variables and cervical lymphadenectomy on survival in patients with upper thoracic esophageal squamous cell carcinoma (scc). | 2009 | 19156473 |
| accuracy of clinical evaluation of locally advanced breast cancer in patients receiving neoadjuvant chemotherapy. | physical examination (pe), mammography (mg), breast magnetic resonance imaging (mri), fluorodeoxyglucose positron emission tomography (pet), and pathologic evaluation are used to assess primary breast cancer. to the authors' knowledge, their accuracy has not been well studied in patients receiving neoadjuvant chemotherapy. accuracies of each modality in tumor and lymph node assessment in patients with t3/t4 tumors receiving neoadjuvant chemotherapy were compared. | 2009 | 19156919 |
| head and neck malignant melanoma: margin status and immediate reconstruction. | head and neck melanoma often approaches critical structures. therefore, excision is often limited, leading to positive margins, and increased local recurrence. immediate reconstruction carries concern for rearrangement or concealment of cancerous tissues. therefore, reconstruction is often delayed until confirming negative margins on permanent pathology. our purpose is to identify variables associated with a positive margin and establish criteria for reconstruction timing. we reviewed 117 consec ... | 2009 | 19158523 |
| [resolution of thyroxine hormone enantiomers by precolumn derivatization with a fluorescent chiral reagent using reversed-phase high performance liquid chromatography]. | a highly fluorescent chiral tagging reagent, r(-)-4-(n,n-dimethylaminosulfonyl)-7-(3-isothiocy-anatopyrrolidino)-2,1,3-benzoxadiazole (r(-)-dbd-pyncs), was employed for the enantiomer separation of thyroxine hormone, d,l-3,5,3',5'-tetraiodothyronine (t4) and l-3,5,3'-triiodothyronine (t3). the reaction of r(-)-dbd-pyncs with the thyroxine enantiomers was carried out at 40 degrees c for 20 min under a basic medium surrounding to yield the corresponding pair of diastereomers. no racemization occur ... | 2008 | 19160753 |
| minimizing endoscopic thoracic sympathectomy for primary palmar hyperhidrosis: guided by palmar skin temperature and laser doppler blood flow. | limiting the extent of sympathectomy in palmar hyperhidrosis was recently recognized as an effective method to minimize the incidence and severity of troublesome compensatory sweating. however, the levels at which transection should be performed remain controversial. in this study, we proposed that the level of ablation varies and should be adjusted for each individual patient. guided by palmar skin temperature and laser doppler blood flow, we try to find the correct target level in each case. | 2009 | 19161752 |
| surgical treatment of primary palmar hyperhidrosis: a prospective randomized study comparing t3 and t4 sympathicotomy. | endoscopic thoracic sympathetic surgery was effective for palmar hyperhidrosis (ph), but side effects such as compensatory sweating and over dry hands were common. a multiple centers prospective randomized study was designed to compare the efficiency and side effects of t3 and t4 sympathicotomy in the treatment of ph. | 2009 | 19162498 |
| the type vi secretion system: translocation of effectors and effector-domains. | a number of prominent gram-negative bacteria use the type vi secretion system (t6ss) to transport proteins across the bacterial envelope. rapid progress is being made in elucidating the structural components of the t6ss apparatus, and a few effectors have been reported to pass through it. however, this is not the complete story: a family of t6ss proteins, the vgrgs, share structural features with the cell-puncturing device of the t4 bacteriophage, and may be used in a similar fashion by bacteria ... | 2009 | 19162533 |
| infralevator lymphatic drainage of low-rectal cancers: preliminary results. | some low-rectal cancers may spread into or recur in the inguinal lymph nodes despite optimal resection of the primary tumor. hence, we hypothesized that lymphatic drainage of low-rectal malignancies may be inhomogeneous and that an extramesorectal route may be involved in at least some cases. the idea of our preliminary study was to analyze the potential lymphatic drainages in low-rectal cancer patients. | 2009 | 19165544 |
| [extended supracricoid partial laryngectomy with tracheocricohyoidoepiglottopexy and tracheocricohyoidoglottopexy]. | to investigate the surgical procedure and indication of the extended supracricoid partial laryngectomy with tracheocricohyoidoepiglottopexy and tracheocricohyoidoglottopexy (escpl+-tchep/tchp) as well as the rehabilitation of laryngeal functions. | 2008 | 19166032 |
| analyzing indirect secondary electron contrast of unstained bacteriophage t4 based on sem images and monte carlo simulations. | the indirect secondary electron contrast (isec) condition of the scanning electron microscopy (sem) produces high contrast detection with minimal damage of unstained biological samples mounted under a thin carbon film. the high contrast image is created by a secondary electron signal produced under the carbon film by a low acceleration voltage. here, we show that isec condition is clearly able to detect unstained bacteriophage t4 under a thin carbon film (10-15 nm) by using high-resolution field ... | 2009 | 19166816 |
| a predictive model for swallowing dysfunction after curative radiotherapy in head and neck cancer. | recently, we found that swallowing dysfunction after curative (chemo) radiation (ch) rt has a strong negative impact on health-related quality of life (hrqol), even more than xerostomia. the purpose of this study was to design a predictive model for swallowing dysfunction after curative radiotherapy or chemoradiation. | 2009 | 19167120 |
| pelvic exenteration for clinical t4 rectal cancer: oncologic outcome in 93 patients at a single institution over a 30-year period. | patients with stage t4 rectal cancer are known to have poor survival and often require pelvic exenteration (pe). we describe the oncologic outcome of pe for patients with clinical t4 rectal cancer over a 30-year period. | 2009 | 19167974 |