| disposition and safety of zonisamide after intravenous and oral single dose and oral multiple dosing in normal hound dogs. | the purpose of this study was to determine an oral dosing regimen of zonisamide in healthy dogs such that therapeutic concentrations would be safely reached and maintained at steady-state. adult hound dogs (n = 8) received a single iv (6.9) and an oral (po) dose (10.3 mg/kg) using a randomized cross-over design. zonisamide was then administered at 10.3 mg/kg po every 12 h for 8 weeks. zonisamide was quantitated in blood compartments or urine by hplc and data were subjected to noncompartmental ph ... | 2008 | 19000278 |
| identification of the 18s-ribosomal-dna genotypes of acanthamoeba isolates from the philippines. | cyst morphology has been commonly used to identify the free-living amoeba acanthamoeba to subgenus level. a more accurate and consistent method, based on the sequence analysis of the gene coding for the amoeba's small-subunit ribosomal rna (rns), has, however, been developed. there have been no attempts to identify the acanthamoeba genotypes circulating in the philippines. in this study, therefore, the asa.s1 region of the rns gene from 17 acanthamoeba isolates, collected from soil, water and co ... | 2008 | 19000384 |
| [changes in alpha2-adrenergic receptors gene expression after high-level spinal cord injury in wistar rats]. | to evaluate the change in alpha(2)-adrenergic receptors (alpha(2)-ars) gene expression after high-level injury of the spinal cord (sci), aiming as developing a more effective perioperative anesthetic management for high-level sci patients. | 2008 | 19000416 |
| [effect of fructose-1,6-diphosphete on myocardial preservation during pulmonary operations]. | to investigate the effect of fructose-1,6-diphosphete(fdp) on myocardial preservation in pulmonary operations. | 2008 | 19001742 |
| [the assessment of acute phase proteins as prognostic factors in patients surgically treated for non-small cell lung cancer]. | the aim of the study was to assess quantitative changes of the acute phase protein (app) serum level in patients with non-small cell lung cancer (nsclc) who underwent a radical resection. we analysed the correlation between quantitative app changes and: the survival rate, the histological type of the cancer, tnm stage and grading. | 2008 | 19003761 |
| nmr data do not implicate a phosphorane in the t4 dna ligase reaction. | | 2008 | 19004796 |
| [work stress, health and satisfaction of life in young doctors. results of a longitudinal study in switzerland]. | based on the effort-reward-imbalance model by siegrist a study was undertaken to find out (a) in what way young doctors assess effort and reward during their specialist training; (b) whether there are certain job stress patterns over time; and (c) what the correlations are, if any, between perceived job stress, health and satisfaction with life. | 2008 | 19006042 |
| structural correlates of the temperature sensitive phenotype derived from saturation mutagenesis studies of ccdb. | temperature sensitive (ts) mutants are widely used to reversibly modulate protein function in vivo and to understand functions of essential genes. despite this, little is known about the protein structural features and mechanisms responsible for generating a ts phenotype. also, such mutants are often difficult to isolate, limiting their use. in this study, a library consisting of 75% of all possible single-site mutants of the 101-residue, homodimeric escherichia coli toxin ccdb was constructed. ... | 2008 | 19006334 |
| the combination of docetaxel and cisplatin plus fluorouracil as neoadjuvant chemotherapy in the treatment of t4 stage gastric cancer. | the prognosis of local advanced gastric carcinoma is very poor. we evaluated the impact on survival and the effects induced by the triple combination docetaxel-cisplatin-fluorouracil (dcf) as neoadjuvant chemotherapy in 24 t4 stage gastric tumor patients. they received 2-3 cycles dcf chemotherapy, followed by radical gastric resection. tumor downstaging detected by ct was obtained in 17 out of 24 patients. the overall 3-year survival rate was 68.2%. patients who received r0 resection (19/22) sho ... | 2010 | 19006661 |
| significance of 18f-fluorodeoxyglucose positron-emission tomography/computed tomography for the postoperative surveillance of advanced renal cell carcinoma. | to evaluate the role of (18)f-fluorodeoxyglucose (fdg) positron-emission tomography (pet)/computed tomography (ct) for the surveillance of patients with renal cell carcinoma (rcc) who have a high risk of local recurrence or distant metastasis, by comparing the results with those of conventional imaging methods. | 2009 | 19007371 |
| [a survey of neuromuscular relaxant use from anaesthesiology residents in training]. | there is need to assess our practice of neuromuscular monitoring according to national consensus guidelines. the aim of this study was to evaluate practice adherence to guidelines in teaching hospitals. | 2008 | 19008070 |
| immuno-modulatory effects of relaxation training and guided imagery in women with locally advanced breast cancer undergoing multimodality therapy: a randomised controlled trial. | eighty women undergoing multimodality treatment for large (>4cm) or locally advanced (t3, t4, tx, n2), breast cancers participated in a randomised controlled trial (rct) to evaluate the immuno-modulatory effects of relaxation training and guided imagery. patients underwent chemotherapy followed by surgery, radiotherapy, and hormone therapy. those in the intervention group were taught relaxation and guided imagery. patients kept diaries of the frequency of relaxation practice and imagery vividnes ... | 2009 | 19008099 |
| short- and long-term follow-up of glomerular and tubular renal markers of kidney function in hyperthyroid cats after treatment with radioiodine. | hyperthyroidism can mask co-existing chronic kidney disease (ckd). previous studies showed that post-treatment renal azotemia can be predicted by pre-treatment assessment of glomerular filtration rate (gfr). we hypothesized that treatment of hyperthyroidism may have different effects on glomerular and tubular function and these changes might be predicted by additional pre-treatment variables than gfr. serum total t4 (tt4), creatinine and blood urea nitrogen (bun), blood pressure (bp), body weigh ... | 2009 | 19010632 |
| thoracic pedicle screws: comparison of start points and trajectories. | experimental design using cadaveric computerized tomography (ct) scans and a computer-assisted image guidance system to compare various thoracic pedicle screw start points and trajectories. | 2008 | 19011548 |
| monitoring of vecuronium-induced neuromuscular blockade during one-lung ventilation. | we investigated the monitoring of neuromuscular blockade caused by vecuronium in patients receiving one-lung ventilation (olv) anesthesia for lung surgery. | 2008 | 19011776 |
| the thyroid hormone mediated effects of insulin on serum leptin levels of diabetic rats. | in this study, we aimed to evaluate the possible relations of serum leptin and thyroid hormones on insulin treatment of surgically thyroidectomized and streptozotosin induced diabetic group of rats and whether the thyroid hormones control the leptin levels or leptin levels affect the thyroid hormones in dm. the sprague-dawley rats were assigned to eight groups: group 1, control; group 2, diabetes (injected intraperitoneally (i.p.) with streptozotocin (stz) 55 mg/kg); group 3, diabetes + insulin ... | 2008 | 19011998 |
| distinguishing childhood absence epilepsy patients from controls by the analysis of their background brain electrical activity. | background electroencephalography (eeg), recorded with scalp electrodes, in children with childhood absence epilepsy (cae) and control individuals has been analyzed. we considered 5 cae patients, all right-handed females and aged 6-8 years. the 15 control individuals had the same characteristics of the cae ones, but presented a normal eeg. the eeg was obtained using bipolar connections from a standard 10-20 electrode placement (fp1, fp2, f7, f3, fz, f4, f8, t3, c3, cz, c4, t4, t5, p3, pz, p4, t6 ... | 2009 | 19013193 |
| enzymatic conversion of long dna to small dna fragments for the construction of short hairpin rna expression libraries. | several techniques to enzymatically construct a short hairpin rna (shrna) expression library have been reported as tools for comprehensive genetic analyses by rna interference. our technique constructs an shrna expression library from 25- to 35-bp dna fragments by fragmenting given double-stranded dna (dsdna). we compared the following two procedures to efficiently prepare such small dna fragments: one is the cleavage of dsdna with deoxyribonuclease i (dnase i) in the presence of mn(2+) followed ... | 2009 | 19013422 |
| removal of viruses from surface water and secondary effluents by sand filtration. | the filtration of phi x 174, ms2, and t4 bacteriophages out of tap water and secondary effluents was performed by rapid sand filtration. the viruses were characterized, and the influence of their microscopic characteristics on filterability was examined by comparing retention values, residence times, attachment, and dispersion coefficients calculated from an advection-dispersion model and residence time variation. the only factor observed to influence retention was virus size, such that the larg ... | 2009 | 19013631 |
| unfolding thermodynamics of intramolecular g-quadruplexes: base sequence contributions of the loops. | g-quadruplexes are a highly studied dna motif with a potential role in a variety of cellular processes and more recently are considered novel targets for drug therapy in aging and anticancer research. in this work, we have investigated the thermodynamic contributions of the loops on the stable formation of g-quadruplexes. specifically, we use a combination of uv, circular dichroism (cd) and fluorescence spectroscopies, and differential scanning calorimetry (dsc) to determine thermodynamic profil ... | 2009 | 19014184 |
| association of thyroid function with arterial pressure in normotensive and hypertensive euthyroid individuals: a cross-sectional study. | abstract: | 2008 | 19014646 |
| metabolic and cardiovascular risk in patients with a history of differentiated thyroid carcinoma: a case-controlled cohort study. | abstract: hyperthyroidism seems to increase metabolic and cardiovascular risk, while the effects of sub-clinical hyperthyroidism are controversial. we evaluated metabolic and cardiovascular parameters in differentiated thyroid carcinoma (dtc) patients with suppressed thyrotropin (tsh) due to levo-thyroxine (l-t4) therapy. we studied dtc patients and, as a control group, patients with a history of surgery for non-malignant thyroid pathology. significantly higher insulin and lower hdl-cholesterol ... | 2008 | 19014658 |
| management of rectal cancer: short- vs. long-course preoperative radiation. | there is considerable debate on the optimum approach to neoadjuvant therapy in rectal cancer. this review of major published studies of short-course preoperative radiation and the more conventional approach of long-course neoadjuvant chemoradiation was undertaken in an effort to understand the potential advantages and disadvantages of each of these approaches. studies were evaluated with regard to patient selection, clinical outcomes, and toxicities. short-course preoperative radiation has shown ... | 2008 | 19014778 |
| halogenated benzenes bound within a non-polar cavity in t4 lysozyme provide examples of i...s and i...se halogen-bonding. | we showed earlier that the mutation of leu99 to alanine in bacteriophage t4 lysozyme creates an internal cavity of volume approximately 150 a(3) that binds benzene and a variety of other ligands. as such, this cavity provides an excellent target to study protein-ligand interaction. here, we use low-temperature crystallography and related techniques to analyze the binding of halogen-incorporated benzenes typified by c(6)f(5)x, where x=h, f, cl, br or i, and c(6)h(5)x, where x=h or i was also stud ... | 2009 | 19014950 |
| patterns of local recurrence in rectal cancer: a single-center experience. | a cohort of patients operated at the national cancer center hospital in tokyo for rectal carcinoma, at or below the peritoneal reflection, was reviewed retrospectively. the purpose was to study the risk factors for local relapse and the patterns of local recurrence. three hundred fifty-one patients operated between 1993 and 2002 for rectal carcinoma, at or below the peritoneal reflection, were analyzed. one hundred forty-five patients, with preoperatively staged t1 or t2 tumors without suspected ... | 2009 | 19015921 |
| degro practical guidelines for radiotherapy of breast cancer ii. postmastectomy radiotherapy, irradiation of regional lymphatics, and treatment of locally advanced disease. | the aim of the present paper is to update the practical guidelines for radiotherapy of breast cancer published in 2006 by the breast cancer expert panel of the german society for radiooncology (degro). these recommendations were complementing the s3 guidelines of the german cancer society (dkg) elaborated in 2004. the present degro recommendations are based on a revision of the dkg guidelines provided by an interdisciplinary panel and published in february 2008. | 2008 | 19016032 |
| cigarette smoking during pregnancy is associated with alterations in maternal and fetal thyroid function. | studies in the general population have shown lower serum tsh levels in smokers as compared with nonsmokers. | 2009 | 19017761 |
| how good is endoscopic ultrasound in differentiating various t stages of rectal cancer? meta-analysis and systematic review. | published data on accuracy of endoscopic ultrasound (eus) in differentiating t stages of rectal cancers is varied. study selection criteria were to select only eus studies confirmed with results of surgical pathology. articles were searched in medline and pubmed. pooling was conducted by both fixed and random effects models. initial search identified 3,630 reference articles, of which 42 studies (n = 5,039) met the inclusion criteria and were included in this analysis. the pooled sensitivity and ... | 2009 | 19018597 |
| thr92ala polymorphism in the type 2 deiodinase is not associated with t4 dose in athyroid patients or patients with hashimoto thyroiditis. | the type 2 deiodinase (d2)-thr92ala polymorphism has been associated with decreased d2 activity in some in vitro experiments but not in others. so far no association between the d2-thr92ala polymorphism and serum thyroid hormone levels has been observed in humans, but in a recent study in athyroid patients, it was suggested that patients homozygous for the ala(92) allele needed higher t4 doses to achieve tsh suppression. we studied the association between the d2-thr92ala polymorphism with thyroi ... | 2009 | 19018782 |
| post-transcriptional control of crp-camp by rnase ls in escherichia coli. | escherichia coli ribonuclease ls was first characterized as a potential antagonist of bacteriophage t4; the e. coli rnla gene is required for this activity. when rnla mutant cells were grown on luria-bertani agar containing a high concentration of nacl, their growth was substantially impaired, and introduction of a mutation into crp or cyaa alleviated the nacl sensitivity. a mutation in rnla caused fivefold overexpression of crp. at the same time, the expression of sigma(38) was lower by two- to ... | 2008 | 19019153 |
| new onset graves' disease as a cause of an adrenal crisis in an individual with panhypopituitarism: brief report. | abstract: : 46 year old patient was admitted as an emergency with vomiting, hypotension and serum cortisol of 0,940 mug/dl (26 nmol/l) indicative of adrenal failure. despite previous history of panhypopituitarism he was found to be hyperthyroid [free t4 6.32 ng/dl (ref. range: 0.93-1.7), free t3 22.21 pg/ml (ref. range: 1.8-4.6)]. he was fit and well till the age of 45. eight months prior to this hospitalisation he presented with diabetes insipidus and was found to have a large cystic tumour in ... | 2008 | 19019235 |
| natural history of mild subclinical hypothyroidism: prognostic value of ultrasound. | clinical repercussions, progression to overt hypothyroidism, and treatment benefits have been well established in patients with subclinical hypothyroidism (sch) and tsh >10 miu/l. in contrast, these aspects of the disease are poorly understood in patients with even milder sch as defined by tsh < or = 10 miu/l and normal thyroid hormone levels. therefore, we sought to evaluate the natural history of this milder form of sch (tsh < or =10 miu/l with normal thyroid hormone levels) in adult women pat ... | 2009 | 19021461 |
| surgical treatment of squamous cell carcinoma of the maxilla and nasal sinuses. | in the treatment of oral squamous cell carcinoma of the maxilla and paranasal sinuses, radical surgery and reconstruction with free flaps is accepted among many clinics. nevertheless, the treatment protocols vary considerably. this study was performed to present our experience in the treatment of maxillary squamous cell carcinoma with surgical means alone, and to try to identify crucial prognostic factors for the patients' survival. | 2008 | 19022122 |
| orthognathic surgery in the young cleft patient: preliminary study on subsequent facial growth. | this study evaluated the long-term effects of orthognathic surgery on subsequent growth of the maxillomandibular complex in the young cleft patient. | 2008 | 19022133 |
| mechanism of heart rate responses elicited by chemical stimulation of the hypothalamic paraventricular nucleus in the rat. | this study was designed to examine the mechanism of heart rate (hr) responses elicited by the stimulation of hypothalamic paraventricular nucleus (pvn). experiments were done in urethane-anesthetized, barodenervated, adult, male wistar rats. chemical stimulation of the pvn by unilateral microinjections of n-methyl-d-aspartic acid (nmda) elicited increases in hr which were attenuated by bilateral vagotomy. pvn-induced tachycardia was also attenuated by the blockade of the spinal ionotropic glutam ... | 2009 | 19022229 |
| [prognostic factors for oral squamous cell carcinoma]. | the aim of the present study was to analyze different prognostic factors to calculate the overall survival in oral squamous cell carcinoma (oscc). samples retrospectively collected from 99 patients with primary oscc were analyzed with regard to tumor node metastasis stage, grading, and 5-year survival time and summarized at an spss 11.0 databank. treated were 72 men and 27 women (average age 59 years) due to oral squamous cell carcinoma. a general 5-year survival time of 57.3% was found. patient ... | 2009 | 19023552 |
| [advance of researches on thyroid tissues autotransplantation and embryonic stem cell transplantation in therapy of hypothyroidism]. | patients with irreversible hypothyroidism require lifelong levo-thyroxin ( l-t4) replacement therapy, which makes them feel discomfortable. with the development of the thyroid tissues autotransplantation and embryonic stem cell (esc), this would be a more physiological approach to the treatment of irreversible hypothyroidism. the animal experiments and human clinical trials on thyroid tissues autotransplantation have shown that the autograft can survive and function. the advanced researches have ... | 2008 | 19024478 |
| role of allosteric switch residue histidine 195 in maintaining active-site asymmetry in presynaptic filaments of bacteriophage t4 uvsx recombinase. | recombinases of the highly conserved reca/rad51 family play central roles in homologous recombination and dna double-stranded break repair. reca/rad51 enzymes form presynaptic filaments on single-stranded dna (ssdna) that are allosterically activated to catalyze atpase and dna strand-exchange reactions. information is conveyed between dna- and atp-binding sites, in part, by a highly conserved glutamine residue (gln194 in escherichia coli reca) that acts as an allosteric switch. the t4 uvsx prote ... | 2009 | 19027026 |
| pilomatrix carcinoma with visceral metastases: case report and review of the literature. | pilomatrix carcinoma, the malignant equivalent of pilomatrixoma, is rare among skin cancers. in the literature, there have been 80 cases of pilomatrix carcinoma reported, and among them nine were with metastases. the clinical presentation of this case is suggestive for the biology and of the usual history of this neoplasm. the patient was a 53-year-old male who had been treated 2 years earlier for a pilomatrix carcinoma located in the posterior part of the neck. the clinical presentation had bee ... | 2009 | 19027384 |
| assessing the efficacy of duddingtonia flagrans chlamydospores per gram of faeces to control haemonchus contortus larvae. | the aims were (a) to quantify the number of duddingtonia flagrans chlamydospores per gram of faeces (cpg) recovered from sheep administered with different oral doses and, (b) to describe the relationship between cpg and eggs per gram of faeces (epg) on the efficacy to reduce haemonchus contortus infective larvae. three doses of chlamydospores per kg bw were orally administered during seven days: (t1) non treated control group, (t2) 1 x 10(6), (t3) 2.5 x 10(6) and (t4) 5 x 10(6). three lambs, inf ... | 2008 | 19028012 |
| molecular characterization, gene expression and transcriptional regulation of thyroid hormone receptors in senegalese sole. | thyroid hormones (ths) play a key role in larval development, growth and metamorphosis in flatfish. their genomic effects are mediated by thyroid hormone receptors (trs). in this study, cdnas encoding for tralphaa, tralphab, and trbeta have been sequenced in senegalese sole (soleasenegalensis). main domains and conserved motifs were identified. also, a truncated tralphab isoform (referred to as tralphabtr) and a spliced trbeta variant (referred to as trbetav) were detected. a phylogenetic analys ... | 2009 | 19028494 |
| effect of low-dose ketamine on inflammatory response in off-pump coronary artery bypass graft surgery. | off-pump coronary artery bypass graft surgery (opcab) is still associated with a marked systemic inflammatory response. the aim of this study was to investigate whether pre-emptive, low dose of ketamine, which has been reported to have anti-inflammatory activity in on-pump coronary artery bypass surgery, could reduce inflammatory response in low-risk patients undergoing opcab. | 2009 | 19028707 |
| elective bilateral above the knee amputation in t4-complete spinal cord injury: a case report. | | 2009 | 19030011 |
| creation of hybrid nanorods from sequences of natural trimeric fibrous proteins using the fibritin trimerization motif. | stable, artificial fibrous proteins that can be functionalized open new avenues in fields such as bionanomaterials design and fiber engineering. an important source of inspiration for the creation of such proteins are natural fibrous proteins such as collagen, elastin, insect silks, and fibers from phages and viruses. the fibrous parts of this last class of proteins usually adopt trimeric, beta-stranded structural folds and are appended to globular, receptor-binding domains. it has been recently ... | 2008 | 19031058 |
| [construction of eukaryotic expression vector expressing hepatitis b virus hbsag and egfp fusion protein and establishment of stable transfected chang liver cell line]. | to construct a eukaryotic expression vector for expressing hepatitis b virus (hbv) recombinant hbsag-egfp fusion protein and obtain a stable transfected chang liver cell line. | 2008 | 19031712 |
| multicentre phase ii trial of paclitaxel and carboplatin with concurrent radiotherapy in locally advanced non-small cell lung cancer. | to evaluate weekly induction chemotherapy followed by weekly concomitant chemoradiotherapy in a multicentre phase ii study of patients with unresectable stage iii non-small cell lung cancer (nsclc; stage wet iiib excluded). | 2008 | 19031924 |
| thyroid function tests and thyroid autoantibodies in an unselected population of women undergoing first trimester screening for aneuploidy. | thyroid dysfunction in early pregnancy is associated with a number of adverse outcomes. furthermore, the presence of thyroid autoantibodies has been associated with an increased risk of miscarriage. | 2008 | 19032663 |
| neonatal thyroxine, maternal thyroid function, and child cognition. | thyroid hormone is essential for normal brain development. limited data are available regarding whether thyroid function in neonates influences later cognitive development. | 2009 | 19033373 |
| [adjuvant therapy of colon carcinoma]. | in patients with stage iii carcinoma of the colon, adjuvant chemotherapy is indicated after r0 resection. no age limitations exist. combination chemotherapy with folfox4 or (if oxaliplatin is contraindicated) monotherapy with a fluoropyrimidine, preferably capecitabine, can be regarded as the standard treatment. because of its unfavorable toxicity profile, the 5-fu/folic acid bolus scheme (the mayo scheme) should no longer be used, and combinations including irinotecan also do not play a part in ... | 2008 | 19033700 |
| spinal anesthesia for transurethral resection operations: bupivacaine versus levobupivacaine. | this study tested the hypothesis that 0.5% levobupivacaine might be a good alternative to 0.5% plain bupivacaine for local spinal anesthesia during transurethral resection (tur) operations. | 2008 | 19034249 |
| initial results of retrospective study: preoperative transurethral excision plus chemotherapy and radiation therapy and trial of bladder preservation. | for patients with invasive bladder cancer the usual recommended treatment is radical cystectomy, although transurethral resection of the tumor, systemic chemotherapy, and radiotherapy are each effective in some patients. this retrospective study evaluated the experience of the clinical oncology department, tanta university hospital with combined modality treatment and selective bladder preservation in patients with muscle-invading bladder cancer with assessment of its safety, tolerance, and effi ... | 2007 | 19034344 |
| cutaneous melanoma in asian-americans. | there is little information available on melanoma in non-white populations. our objective was to characterize melanoma in asian-americans (asa) and compare patient demographics and tumor characteristics with the non-hispanic white (nhw) population. | 2009 | 19034932 |
| arthritis-related work transitions: a prospective analysis of reported productivity losses, work changes, and leaving the labor force. | to prospectively examine arthritis-related productivity losses, work changes, and leaving employment, the relationships among these work transitions, and the factors associated with them. | 2008 | 19035423 |
| pediatric reference intervals for thyroid hormone levels from birth to adulthood: a retrospective study. | age- and sex-specific reference intervals are an important prerequisite for interpreting thyroid hormone measurements in children. however, only few studies have reported age- and sex-specific pediatric reference values for tshbasal (tsh), free t3 (ft3), and free t4 (ft4) so far. reference intervals are known to be method- and population-dependent. the aim of our study was to establish reference intervals for serum tsh, ft3, and ft4 from birth to 18 years and to assess sex differences. | 2008 | 19036169 |
| results of a phase ii trial of cetuximab plus capecitabine/irinotecan as first-line therapy for patients with advanced and/or metastatic colorectal cancer. | xeliri (capecitabine/irinotecan) is effective and well tolerated in metastatic colorectal cancer (mcrc). cetuximab is active in mcrc alone or with chemotherapy. this study evaluated cetuximab plus xeliri in first-line treatment of mcrc. | 2008 | 19036692 |
| effectiveness of long-term augmentation with citalopram to clomipramine in treatment-resistant ocd patients. | the high percentage (between 40% and 60%) of resistance to first-line drugs, such as clomipramine or selective serotonin reuptake inhibitors, is a major problem in the pharmacologic management of obsessive-compulsive disorder (ocd). in these cases, different strategies have been employed with controversial outcomes. the meager information available on the association of two serotonergic drugs prompted us to explore the possible effectiveness and tolerability of citalopram+clomipramine in resista ... | 2008 | 19037176 |
| public health genomics: translating obesity genomics research into population health benefits. | we examine how a public health genomics framework can be used to move genomic discoveries into clinical and public health practice for obesity prevention and treatment. there are four phases of translational research: t1: discovery to candidate health application; t2: health application to evidence-based practice guidelines; t3: practice guidelines to health practice; and t4: practice to population health impact. types of multidisciplinary research and knowledge synthesis needed for each phase, ... | 2008 | 19037221 |
| association between survivin gene promoter -31 c/g polymorphism and urothelial carcinoma risk in taiwanese population. | to investigate the association between survivin gene promoter -31 c/g polymorphism and urothelial carcinoma (uc) risk in a taiwanese population. | 2009 | 19038421 |
| chemoradiation for unresectable stage iii non-small cell lung cancer. | patients with unresectable stage iii nonsmall cell lung cancer (t4, n3, or bulky n2) live longer if they receive chemotherapy before or concurrent with thoracic irradiation. randomized clinical trials have shown that concurrent chemoradiation is superior to sequential chemotherapy followed by radiation, with a 20% reduction in the risk of death compared with the sequential approach. however, concurrent chemoradiation is more toxic than the sequential approach, with an increased risk of radiation ... | 2008 | 19038729 |
| use of polishing pond effluents to cultivate lettuce (lactuca sativa) in a hydroponic system. | the sanitary quality and productivity of hydroponic lettuce (lactuca sativa l.) plants cultivated under greenhouse conditions and treated with effluent from anaerobic reactor + polishing pond followed by physical-chemical treatment was evaluated. two hydroponic cultivations were performed at summer and winter time at vitoria-es, brazil. the treatments for both cultivations were: t1) conventional nutrient solution, t2) effluent from physical-chemical treatment, t3) effluent from polishing pond, a ... | 2008 | 19039187 |
| [the role of gap-junction in suspended animation for hemorrhagic shock with brain injury: experiment with rats]. | to investigate the role of gap-junction in suspended animation for hemorrhagic shock with brain injury. | 2008 | 19040009 |
| comparison of long-term cidr-based protocols to synchronize estrus in beef heifers. | two experiments evaluated long-term controlled internal drug release (cidr) insert-based protocols to synchronize estrus and compare differences in their potential ability to facilitate fixed-time artificial insemination (ftai) in beef heifers. in experiment 1 estrous cycling heifers (n=85) were assigned to one of two treatments by age and body weight (bw). heifers with t1 received a cidr from days 0 to 14, gonadotropin releasing hormone (gnrh) on day 23, and prostaglandin f(2 alpha) (pg) on day ... | 2009 | 19042099 |
| heterophile antibody interference with thyroid assay. | immunoassays are one of the main methods of measuring thyroid hormones. they are prone to interference. interference of the immunoassays has been increasingly recognized as a problem because it may lead to misinterpretation of results resulting in unnecessary investigation and wrong course of treatment. we describe a patient who had interference in her thyroid function measurements (free t4, free t3 and tsh) during the course of treatment for graves' disease. | 2008 | 19043256 |
| calculation of absolute protein-ligand binding free energy using distributed replica sampling. | distributed replica sampling [t. rodinger et al., j. chem. theory comput. 2, 725 (2006)] is a simple and general scheme for boltzmann sampling of conformational space by computer simulation in which multiple replicas of the system undergo a random walk in reaction coordinate or temperature space. individual replicas are linked through a generalized hamiltonian containing an extra potential energy term or bias which depends on the distribution of all replicas, thus enforcing the desired sampling ... | 2008 | 19045232 |
| effects of perfluorooctane sulfonate on rat thyroid hormone biosynthesis and metabolism. | the potential toxicity of perfluorooctane sulfonate (pfos), an environmentally persistent organic pollutant, is of great concern. the present study examines the ability of pfos to disturb thyroid function and the possible mechanisms involved in pfos-induced thyroid hormone alteration. male sprague-dawley rats were exposed to 1.7, 5.0, and 15.0 mg/l of pfos in drinking water for 91 consecutive days. serum was collected for analysis of total and free thyroxine (t4), total triiodothyronine (t3), an ... | 2009 | 19045937 |
| low-dose combined spinal-epidural anaesthesia for caesarean section in a patient with eisenmenger's syndrome. | a 34-year-old woman (g3,p0) with eisenmenger's syndrome and positive hiv serology presented to hospital at 16 weeks of pregnancy. she was hospitalised at 20 weeks under the care of a multidisciplinary team. at 33 weeks caesarean section was performed under low-dose combined spinal-epidural anaesthesia using a needle-through-needle technique. over a period of 10 min, spinal anaesthesia produced a sensory block to t4 which did not alter oxygenation or blood pressure. epidural supplementation was n ... | 2009 | 19046874 |
| high expression of her3 is associated with a decreased survival in gastric cancer. | the role of human epidermal growth factor receptor (her) 3 and her4 has been elucidated in gastric cancer. her1 and her2 overexpression are regarded as prognostic factors and targets of treatment. the dimerization of the her family receptors activates downstream signal pathways and promotes tumor progression. this study investigated the positive correlation between her1 and her4 expression and the prognosis of patients with gastric cancers. | 2008 | 19047113 |
| current status and future prospects in prosthetic voice rehabilitation following laryngectomy. | total laryngectomy or laryngopharyngectomy remains the procedure of choice for advanced-stage (uicc t3 and t4) laryngeal carcinoma around the world despite advances in conservative laryngeal surgery and radiotherapy. however, it has profound effects on respiration and deglutition, in addition to the most disabling effect-the loss of verbal communication. successful voice restoration can be attained with any of three speech options, namely esophageal speech, electrolarynx, and tracheoesophageal ( ... | 2008 | 19052392 |
| supplementations of hyparrhenia rufa -dominated hay with groundnut cake- wheat bran mix: effects on feed intake, digestibility and nitrogen balance of somali goats. | a digestibility and nitrogen (n) balance experiment was conducted using twenty yearling male somali goats weighing 23.4 +/- 2.02 (mean+/-sd). the objectives of the study were to evaluate the effects of supplementation with graded levels of mixture of groundnut cake and wheat bran at a ratio of 3:1 on dm basis on feed intake, apparent digestibility and n balance in somali goats. the experimental design was a completely randomized design consisting of five animals in each treatment. the dietary tr ... | 2009 | 19052893 |
| effectiveness of strategic anthelmintic treatments in the control of gastrointestinal nematodes and fasciola gigantica in cattle in iringa region, tanzania. | a longitudinal field trial was conducted to determine the effectiveness of strategic anthelmintic treatments in the control of gastrointestinal (gi) nematodes and fasciola gigantica in cattle. a total of 167 cattle (6-18 months) from three large-scale dairy farms, four traditional farms and nine small-scale dairy farms were randomly selected. the selected animals on each farm were ear tagged and allocated into three groups based on live weight and treated as follows: group t4 was treated with al ... | 2009 | 19052899 |
| prevalence of palpable thyroid nodule in isfahan, iran, 2006: a population based study. | this cross-sectional study enrolled 2 523 of adult general population (age > 20 years) of isfahan city. history taking and thyroid exam was performed by seven trained general practitioners. the concentration of tsh was measured in all, tgab and tpoab in approximately one in six and urinary iodine concentration in one fourth of them, randomly. we recalled people with any suspicious abnormality in thyroid exam or whose tsh levels were not normal at present or past. they were re-visited by an endoc ... | 2009 | 19053026 |
| ku70 or ku80 deficiencies in the fungus botrytis cinerea facilitate targeting of genes that are hard to knock out in a wild-type context. | the filamentous ascomycete botrytis cinerea is one of the most studied models for understanding the necrotrophic behaviour of phytopathogenic fungi. the genomes of two strains of b. cinerea have been sequenced (b05.10 and t4), which may contribute to elucidating the virulence polymorphism in this fungus. in this study, both strains were genetically modified in order to construct recipient strains designed to target genes that are hard to knock out. deletions of bcku70 gene in b05.10 strain and b ... | 2008 | 19054110 |
| [neoadjuvant systemic therapy in patients with operable primary breast cancer: more benefits than breast-conserving therapy]. | to analyse the extent to which primary systemic therapy (pst) achieves the main goals in patients with operable primary breast cancer, these goals being breast-conserving therapy and pathological complete remission (pcr), and to evaluate the response. | 2008 | 19055260 |
| progress in ab initio qm/mm free-energy simulations of electrostatic energies in proteins: accelerated qm/mm studies of pka, redox reactions and solvation free energies. | hybrid quantum mechanical/molecular mechanical (qm/mm) approaches have been used to provide a general scheme for chemical reactions in proteins. however, such approaches still present a major challenge to computational chemists, not only because of the need for very large computer time in order to evaluate the qm energy but also because of the need for proper computational sampling. this review focuses on the sampling issue in qm/mm evaluations of electrostatic energies in proteins. we chose thi ... | 2009 | 19055405 |
| metabolic profiles in goat does in late pregnancy with and without subclinical pregnancy toxemia. | pregnant goat does can develop various metabolic diseases during late pregnancy that may have profound effects on their health and productivity, including subclinical pregnancy toxemia. | 2008 | 19055580 |
| spinal gnathostomiasis resembling an intrinsic cord tumor/myelitis in a 4-year-old boy. | a 4-year-old boy presented with fever, myalgia followed by progressive quadriparesis and urinary retention. spinal fluid from a lumbar puncture showed 42 wbc/microl with 100% lymphocytes, no rbc, a glucose of 54 mg/dl (blood glucose 107 mg/dl), and a protein of 39 mg/dl. the cerebrospinal fluid culture was negative. his white blood cell count was 10,860 cells/microl with a normal differential count. an mri of the brain was negative. an mri of the whole spine showed fusiform dilatation of the cer ... | 2008 | 19058570 |
| genotyping of acanthamoeba isolates from clinical and environmental specimens in iran. | in this study, 15 acanthamoeba isolates from ak patients and 10 environmental samples (water, soil and animal-origin samples) were classified at the genotype level based on the sequence analysis of the diagnostic fragment 3 (df3) of acanthamoeba small subunit rrna gene. the obtained results revealed that most of these acanthamoeba strains belonged to genotype t4 both in clinical and environmental samples. the presence t11 genotype in clinical samples was also revealed after the genotyping analys ... | 2009 | 19059239 |
| sustained benefit lasting one year from t4 instead of t3-t4 sympathectomy for isolated axillary hyperhidrosis. | level t4 video-assisted thoracoscopic sympathectomy proved superior to t3-t4 treatment for controlling axillary hyperhidrosis at the initial and six-month follow-ups of these patients. | 2008 | 19060999 |
| [multivisceral resection in locally advanced colorectal cancer: analysis of associated humoral and clinical factors]. | colorectal cancer is locally advanced in 10-20% of cases. in these cases the surgical procedure of multivisceral resection is used in an attempt to obtain a curative result. the aim of the present study was to assess survival and biological humoral and clinical factors in patients subjected to multivisceral resection in our surgical unit. fifteen patients affected by advanced colorectal cancer (t4) subjected to multivisceral resection are compared with a population of 19 patients subjected to st ... | 2008 | 19062487 |
| [prognostic and therapeutic value of d2 lymphadenectomy in the treatment of gastric cancer: experience of an italian team]. | recently, the incidence of gastric cancer and the related percentage of mortality have been decreasing world-wide, especially in the industrialised countries. surgery has commonly been opted for as primary treatment of this disease. however, the optimal extent of surgical intervention is still debated. japanese surgeons have been the pioneers of perigastric and celiac tripod lymphadenectomies in an attempt to improve long-term survival and the postoperative disease-free period. in recent years, ... | 2008 | 19062490 |
| preliminary evidence that a functional polymorphism in type 1 deiodinase is associated with enhanced potentiation of the antidepressant effect of sertraline by triiodothyronine. | triiodothyronine (t3) is used to potentiate the clinical effect of antidepressant drugs. inter-individual differences in efficacy may be related to genetically-based variability in thyroid function. | 2009 | 19064291 |
| enhanced proatherogenic inflammation after recombinant human tsh administration in patients monitored for thyroid cancer remnant. | to evaluate the effect of recombinant human tsh (rhtsh) on biomarkers of vascular endothelial cell and platelet activation in patients monitored for thyroid carcinoma remnant. | 2009 | 19067724 |
| chronic postnatal de-71 exposure: effects on learning, attention and thyroxine levels. | polybrominated diphenyl ethers (pbdes) are ubiquitous, bioaccumulative flame retardants. much remains to be learned about their developmental toxicological properties, particularly with regards to chronic exposure. in two experiments, male long-evans rats ingested the commercial pentabde mixture de-71 from birth onward, first through the milk of lactating dams (who ingested 5 or 7.5 mg de-71/day in a custom-mixed chow), then directly via chow consumption (at a dose of 3 or 4.5 mg/day). control r ... | 2009 | 19068229 |
| effect of chemical paclobutrazol on growth, yield and quality of okra (abelmoschus esculentus l.) har lium cultivar in northeast thailand. | this investigation was carried out at mahasarakham university experimental farm, mahasarakham university, northeast thailand in the late rainy season of the 2003 to 2004 with the use of roi-et soil series (oxic paleustults). the experiment aims to search for more information on the effect of different rates of chemical paclobutrazol (pbz) application on growth, yield and quality of edible okra pods. a randomised complete block design (rcdb) with four replications was used for the experiment. the ... | 2007 | 19069514 |
| body mass index and thyroid function in adolescent girls. | the present research was conduted to examine the relationship between thyroid function and body mass index. a cross-sectional study was carried out in lar province and its' vicinity in south of iran. by stepwise random sampling from all public girls' high schools, 227 high school participants (aged 12-21) were selected. serum samples were collected and assayed for triiodothyronine (t3), thyroxine (t4), thyroid stimulating hormone (tsh), reverse triiodothyronine (rt3), free thyroxine (ft4), free ... | 2007 | 19069886 |
| serum proteins and some biochemical parameters in broiler chickens fed with raw and treated bitter vetch (vicia ervilia) seeds. | this study carried out to evaluate the effect of bitter vetch seeds on serum proteins and biochemical parameters in broiler chickens. a total of 1320 one-day-old broiler chicks of a commercial breed were placed in 64 pens. treatments were included raw and four different processed bitter vetch seeds in three levels (150, 300 and 450 g kg(-1)) and a corn-soybean based diet as control. each treatment group consisted of four replicates. processing methods were included soaked in water for 12 h, auto ... | 2007 | 19069902 |
| effects of green manures on growth, yield and quality of green okra (abelmoschus esculentus l.) har lium cultivar. | this green manure experiment with the use of okra crop as indicator plant was carried out at mahasarakham university experimental farm, mahasarakham province, northeast thailand during may to september 2005 to investigate four types of green manure legume crops on growth, yield and quality of edible fresh pods of okra crop when grown on roi-et soil series (oxic paleustults). the four types of green manure plants include jack bean, cowpea, green gram, and giant sensitive plant. the experiment con ... | 2007 | 19070046 |
| bisphosphonate-induced osteonecrosis of the jaws, bone markers, and a hypothesized candidate gene. | to determine whether any abnormality in serum bone markers is related to bisphosphonate-induced osteonecrosis of the jaw. | 2009 | 19070762 |
| acanthamoeba castellanii: high antibody prevalence in racially and ethnically diverse populations. | acanthamoeba is an opportunistic protozoan pathogen that can produce keratitis and rare but fatal encephalitis. in the present study, we examined secretory iga antibody to acanthamoeba castellanii of the t4 genotype in mucosal secretions from 114 individuals of 37 countries, inhabitants and/or visitors, aged 16-65 years in london, uk. acanthamoeba antibody prevalence rate was more than 85%, without any significant differences between males (86.2%) and females (89.2%). some epidemiological factor ... | 2009 | 19071116 |
| bacteriophage-modified microarrays for the direct impedimetric detection of bacteria. | a novel method is presented for the specific and direct detection of bacteria using bacteriophages as recognition receptors immobilized covalently onto functionalized screen-printed carbon electrode (spe) microarrays. the spe networks were functionalized through electrochemical oxidation in acidic media of 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (edc) by applying a potential of +2.2 v to the working electrode. immobilization of t4 bacteriophage onto the spes was achieved via edc by formati ... | 2008 | 19072262 |
| characterization of ligands for thyroid receptor subtypes and their interactions with co-regulators. | thyroid hormone receptors (trs) are nuclear receptors that are activated by thyroid hormone ligands and co-regulator proteins. two receptor subtypes, tralpha and trbeta, have been suggested to play a role in numerous physiological functions. however, specificity of receptor subtype function and co-regulator interaction is unclear due to the lack of tr subtype-specific ligands. five tr ligands were evaluated for their selectivity and interaction with the tr subtypes. a multiplex assay was used to ... | 2009 | 19073200 |
| [effects of 22 microsatellite dna markers on stress traits in f2 population of pigs]. | in the present study, we analyzed the effects of 22 microsatellite dna loci on behavior responses and plasma concentration of hormones related to stress and metabolism following transport trial in pigs. these subjects were selected from the segregating f2 generation of a pietrain (pie) x erhualian (ehl) cross, and the two swine strains differ in stress tolerance. a so-called backtest score (bs) at 3, 10 and 17 days after birth (bs3, bs10 and bs17) was implemented to assess the behavior responses ... | 2008 | 19073553 |
| thyroid hormone action: nongenomic modulation of neuronal excitability in the hippocampus. | years of effort have failed to establish a generally-accepted mechanism of thyroid hormone (th) action in the mature brain. recently, both morphological and pharmacological evidence have supported a direct neuroactive role for the hormone and its triiodinated metabolites. however, no direct physiological validation has been available. we now describe electrophysiological studies in vivo in which we observed that local thyroxine (t4) administration promptly inhibited field excitatory postsynaptic ... | 2009 | 19076268 |
| adult onset idiopathic phosphate diabetes. | this report describes the clinical and biologic data and bone density measurements in 19 adults seen in a rheumatology department, with phosphate diabetes defined by low serum phosphate levels and decreased tubular reabsorption of phosphate in the absence of known etiology. there were 14 males and 5 females with a mean age at disease onset of 36.7 years (20-68 years) and at diagnosis of 43.9 years (24-70 years). axial pain was present in 17 patients (90%), radicular pain in 13 patients (68%), pa ... | 1996 | 19078033 |
| postoperative pituitary hormonal disturbances and hormone replacement therapy time and dosage in children with craniopharyngiomas. | the proliferative activity and penetration into the hypothalamic structures in children craniopharyngiomas (cp) often make radical resection difficult. therefore, complete resection of cp often results in permanent multiple pituitary hormone deficiency (mphd). this study aimed to elucidate the postoperative pituitary hormonal disturbances, and hormone replacement therapy (hrt) time and dosage in children with cp. | 2008 | 19080279 |
| [mrna expression of basic fibroblast growth factor and hepatocyte growth factor in gastric carcinoma and significance thereof]. | to investigate the mrna expression of basic fibroblast growth factor (bfgf) and hepatocyte growth factor (hgf) in gastric carcinoma and correlation thereof with intratumoral microvascular density (imd), proliferating cell nuclear antigen labeling index (pcna li), tumor invasion and metastasis, and patients' survival. | 2008 | 19080429 |
| [changes of granulocyte distribution induced by thyroxin and epinephrine: experiment with rabbits]. | to investigate the distribution of granulocyte during thyrotoxicosis and the relation of granulopenia and the gathering of circulating granulocytes into the marginal pool. | 2008 | 19080490 |
| molecular phylogenetics: testing evolutionary hypotheses. | a common approach for investigating evolutionary relationships between genes and organisms is to compare extant dna or protein sequences and infer an evolutionary tree. this methodology is known as molecular phylogenetics and may be the most informative means for exploring phage evolution, since there are few morphological features that can be used to differentiate between these tiny biological entities. in addition, phage genomes can be mosaic, meaning different genes or genomic regions can exh ... | 2009 | 19082555 |
| an investigation on the germination of seeds of kwao kreu kao (pueraria candollei grah. ex benth) as affected by both water soakings and hot air oven treatments. | this experiment was carried out at the faculty of technology, mahasarakham university, mahasarakham 4400, thailand to investigate effects of different water-soaking durations and hot air oven treatments on the germination of seeds of kwao kreu kao (pueraria candollei grah. ex benth) plants. the experiment was laid in a randomised complete block design with four replications. the results showed that after tested for electrical conductivity (ec) values for cracking of seeds, all seeds being used w ... | 2007 | 19086573 |
| efficacy of a new rehabilitative device for individuals with spinal cord injury. | regular exercise is required in persons with spinal cord injury (sci) to reduce the deleterious effects of chronic paralysis. the primary aims of the study were to examine responses to passive and active exercise on a new rehabilitative device for persons with sci and to examine reliability of these responses over 2 days of testing. | 2008 | 19086717 |