| resection line involvement after gastric cancer surgery: clinical outcome in nonsurgically retreated patients. | resection line infiltration (rli) after surgical treatment represents an unfavorable prognostic factor in advanced gastric cancer. we performed a retrospective analysis of 89 patients with resection line involvement who did not undergo reoperation. | 2008 | 18825453 |
| differential gene expression profiles of normal human parotid and submandibular glands. | parotid and submandibular glands have different properties including characteristics of the secreted saliva and tumor incidences. the differences in properties of parotid and submandibular glands are not clear from a genetic viewpoint. | 2008 | 18826381 |
| serum concentrations of bnp and anp in patients with thyrotoxicosis. | serum bnp (brain naturiuretic peptide) and anp (atrial natriuretic peptide) levels are reportedly elevated in patients with thyrotoxicosis. the increases may not be due to thyrotoxicosis itself but to secondary cardiovascular changes such as chronic heart failure (hf) or atrial fibrillation (af) which frequently accompany thyrotoxicosis. we measured serum anp and bnp levels in 130 patients with thyrotoxicosis and correlated them with hf severity and thyroid function. thirty-seven normal subjects ... | 2009 | 18827406 |
| prevalence of hypothyroidism and importance of cholesterol estimation in patients suffering from major depressive disorder. | the coexistence of hypothroidism and depression is already reported and both of these conditions are known to share some common clinical symptoms. serum cholesterol level is known to be altered in either condition considered separately. but, no report is obtained regarding serum cholesterol level when both the conditions coexist. in this study, 78 patients (61 females and 17 males, age ranged 19 to 67 years) suffering from major depressive disorder were included. serum t3, t4, tsh and cholestero ... | 2008 | 18828343 |
| relationship between the hypothalamic-pituitary-thyroid axis and alcohol craving in alcohol-dependent patients: a longitudinal study. | a relationship between some hypothalamic-pituitary-related hormones and craving for alcohol has been suggested, leading to hypothesize a role of some hormones in the neurobiology of alcohol dependence. investigating this association in alcohol-dependent (ad) patients was the aim of this preliminary and exploratory study. | 2008 | 18828809 |
| thyroglobulin may affect telomerase activity in thyroid follicular cells. | telomerase (ta) activity is known to be present in malignant tumor cells, but not in most somatic differentiated cells. ta shows relatively high activity in thyroid cancer cells, but reports vary. this fact prompted us to elucidate whether cell component inhibitors of ta in the thyroid follicles can modulate its activity. the activity of ta extracted from hela cells was inhibited by mixing with the supernatant fraction of human thyroid tissue extract. to examine the effect of iodine, thyroid hor ... | 2009 | 18830915 |
| head and neck squamous cell carcinoma in 13 patients with fanconi anemia after hematopoietic stem cell transplantation. | fanconi anemia (fa) is a chromosomal instability disorder with a very high risk of developing head and neck squamous cell carcinoma (hnscc), most notably after hematopoietic stem cell transplantation (hsct). | 2008 | 18831513 |
| a novel thermophilic lysozyme from bacteriophage phiin93. | the lysozyme of bacteriophage phiin93 was purified to apparent homogeneity with carboxymethyl sepharose and hydroxyapatie columns from lysates of the phage grown on thermus aquaticus tz2. the enzyme is a single polypeptide chain with a molecular weight of 33,000. from the determined n-terminal amio acids of the enzyme, the locus of the gene was specified on a phiin93 genome. the enzyme was not similar to egg white lysozyme, t4 phage lysozyme, or lambda phage lysozyme. the enzyme, phiin93 lysozym ... | 2008 | 18831965 |
| squamous cell carcinoma of the buccal mucosa: a retrospective analysis of 22 cases. | we examined our institution's experience with 22 cases of previously untreated buccal squamous cell carcinoma via a retrospective chart review. eleven of these patients had been treated with a combination of surgical excision and postoperative radiation therapy, 8 patients with surgical excision alone, and 3 patients with radiation therapy alone. the overall 3-year locoregional recurrence rate was 32% (n = 7). the 3-year survival rates were 82% after surgery plus radiation (9 of 11 patients), 63 ... | 2008 | 18833538 |
| a pilot study on thoracoscopic internal mammary lymphatic chain dissection for breast cancer. | to evaluate the feasibility of internal mammary lymphatic chain dissection by thoracoscopic surgery. | 2008 | 18835167 |
| prognostic value of metabolic imaging in non-small cell lung cancers with neoplasic pleural effusion. | the intensity of the [f]fluorodeoxyglucose (f-fdg) uptake is an independent prognostic indicator in non-small cell lung cancer (nsclc). we evaluate the relationship between the metabolic activity of the primary and the pleurisy in t4 nsclc. | 2008 | 18836376 |
| [neoplasms of paranasal sinuses in material of ent department mss hospital in warsaw between 2006-2007]. | tumors of paranasal sinuses present a small percent of tumors detected in the region of head and neck 3-4% and they present a fraction of a percent of tumors in general /0.16%/. material: in the years 2004 and 2005, the national register of neoplasms recorded 120 and 132 cases of malignant tumors of paranasal sinuses, respectively. between 2006-2007 we treated 15 patients with tumors of paranasal sinuses underwent treatment at the ent department of the miedzyleski szpital specjalistyczny in wars ... | 2008 | 18837222 |
| robot-assisted laparoscopic radical prostatectomy: perioperative outcomes of 1500 cases. | robot-assisted laparoscopic radical prostatectomy (ralp) is an evolving minimally invasive treatment of for localized prostate cancer. we present our experience of 1500 consecutive cases with an analysis of perioperative outcomes. | 2008 | 18837657 |
| early treatment with low fixed dose (5 mci) radioiodine therapy is effective in indian subjects with graves' disease. | there is little consensus regarding the most appropriate dosage regimen for radioiodine treatment in graves' disease. the authors evaluated the efficacy of low fixed dose (5mci) of radioiodine therapy, in terms of its cure rate and promptness of control, as well possible factors influencing the outcome. one hundred and twenty five consecutive patients with graves' disease with persistent disease activity despite receiving carbimazole were treated with 5 mci fixed dose of i131. patients, who rema ... | 2008 | 18839646 |
| a study on endocrine changes in patients in intensive care unit. | pattern of endocrine changes in moderate to severely ill patients in a medical intensive care unit, correlation with the severity of illness and whether these changes can predict outcome of the critically ill patients were evaluated and studied in 80 patients admitted with acute physiology and chronic health evaluation (apache) ii score >10 and without any pre-existing endocrinopathies or on drugs likely to affect the endocrine axis. adrenal insufficiency was present in 45%, and mortality was hi ... | 2008 | 18839647 |
| a multifactorial approach to the factors influencing determination of paravertebral depth. | predicting the depth of needle insertion for paravertebral nerve blocks is currently based on patients' anthropometric characteristics, and the block level. although preliminary studies report relationships between paravertebral depth and the body mass index (bmi), the number of observations, to date, are inadequate to formulate reliable conclusions. this study was designed to determine which factors may predict the distance between the skin and paravertebral space, for patients undergoing parav ... | 2008 | 18840588 |
| increased thyroid blood flow in the hypoechoic lesions in patients with recurrent, painful hashimoto's thyroiditis at the time of acute exacerbation. | we report two cases with painful hashimoto's thyroiditis, who developed recurrent fever and painful thyroid. glucocorticoid treatment was transiently successful but tenderness in the thyroid gland and fever developed when glucocorticoid was tapered. one patient underwent total thyroidectomy uneventfully. as is well known, it is frequently difficult to make differential diagnosis between painful hashimoto's thyroiditis and subacute thyroiditis particularly at the initial phase. interestingly, col ... | 2009 | 18840927 |
| [crossed pattern of sensory loss with left thoracic level in a right dorsolateral medullary infarction]. | introduction: medullary infarctions as consequence of vertebro-basilar strokes are frequent findings in clinical practice. medulla oblongata, the lowest segment of the brainstem, is a dense anatomic structure with different conglomerate of nuclei, ascending and descending pathways within a very small area and tiny insults can present with expressive clinical manifestations. sensory dysfunction is often a noteworthy element in lateral medullary infarctions and its distribution depends of the site ... | 2008 | 18841547 |
| the confine-and-release method: obtaining correct binding free energies in the presence of protein conformational change. | free energy calculations are increasingly being used to estimate absolute and relative binding free energies of ligands to proteins. however, computed free energies often appear to depend on the initial protein conformation, indicating incomplete sampling. this is especially true when proteins can change conformation on ligand binding, as free energies associated with these conformational changes are either ignored or assumed to be included by virtue of the sampling performed in the calculation. ... | 2007 | 18843379 |
| vegf, tnf-alpha and 8-isoprostane levels in exhaled breath condensate and serum of patients with lung cancer. | the aim of the present study was to evaluate the levels of vegf, 8-isoprostane and tnf-alpha in ebc and serum of patients with primary lung cancer prior to the initiation of any treatment, in order to evaluate their possible diagnostic role. furthermore, associations between vegf, 8-isoprostane and tnf-alpha levels in ebc and serum with clinicopathologic factors were investigated. we enrolled 30 patients with lung cancer (mean age 65.2+/-10.5 years) and 15 age and gender-matched healthy smokers ... | 2009 | 18845357 |
| re-irradiation of head and neck carcinoma. | to determine the efficacy of re-irradiation of patients with head and neck carcinoma we reviewed the pertinent literature. depending on the location and extent of the tumor, re-irradiation may be accomplished with external beam radiotherapy (rt), brachytherapy, intraoperative rt, and/or radiosurgery. the likelihood of cure is impacted by the interval between the initial course of rt and re-irradiation, whether the carcinoma is a recurrence or a second primary tumor, initial t-stage, and recurren ... | 2008 | 18846001 |
| amiodarone-induced thyrotoxicosis. a review. | amiodarone (am), a potent class iii anti-arrhythmic drug, is an iodine-rich compound with a structural resemblance to thyroid hormones triiodothyronine (t3) and thyroxine (t4). at the commonly employed doses, am causes iodine overload up to 50-100 times the optimal daily intake, which may be responsible of a spectrum of effects on thyroid function often counterbalancing its heart benefits. although most patients on chronic am treatment remain euthyroid, a consistent proportion may develop thyrot ... | 2008 | 18846027 |
| treatment and prevention of lymphorrhea after radical gastrectomy of gastric cancer. | lymphorrhea is an uncommon complication of abdominal surgery. here, we retrospectively investigate the treatment and prevention of lymphorrhea after radical gastrectomy. | 2009 | 18846385 |
| a simplified tumor regression grade correlates with survival in locally advanced rectal carcinoma treated with neoadjuvant chemoradiotherapy. | locally advanced rectal cancer is frequently treated with neoadjuvant chemoradiotherapy to reduce local recurrence and possibly improve survival. the tumor response to chemoradiotherapy is variable and may influence the prognosis after surgery. this study assessed tumor regression and its influence on survival in patients with rectal cancer treated with chemoradiotherapy followed by curative surgery. | 2008 | 18846402 |
| [in vivo study of fidelity of dna double-strand break repair in bacteriophage t4]. | a method for in vivo studying the fidelity of dna double-strand break (dsb) repair in bacteriophage t4 has been developed. the frequency of reversion of rii mutations to the wild phenotype was measured in i segc+ x i ets 1 segcdelta crosses, where ets 1 is an insertion in the initial part of the rii gene carrying a sequence recognized by segc endonuclease; i designates a riib or riia mutation located at some distance from ets 1, and segcdelta is a deletion in the segc gene. in such cross, a dsb ... | 2008 | 18846814 |
| staging esophageal cancer. | accurate staging of disease is necessary in patients with newly diagnosed esophageal cancer in order to prompt appropriate curative or palliative therapy. computed tomography (ct) may be used to evaluate for local spread into adjacent structures (t4 disease) and to diagnose distant metastases (m1). endoscopic ultrasonography (eus) is the modality of choice for distinguishing t1 tumors from higher stage lesions and for detecting and sampling regional lymph nodes (n1 disease). positron emission to ... | 2008 | 18852079 |
| assessment of demographics factors and clinical staging in patients submitted to salvage surgery for oropharyngeal squamous cell carcinoma. | the usual management of upper aero digestive tract squamous cell carcinoma is surgery associated or not to post surgical radiotherapy. loco-regional relapses constitute the main failure of the initial treatment and early diagnosis justifies the indication of salvage surgery. | 2008 | 18852978 |
| assessment of clinical and therapeutic factors in patients with nasopharyngeal undifferentiated carcinoma. | the nasopharyngeal carcinoma (npc) is a rare cancer with a high incidence in southern asia. | 2008 | 18852983 |
| application of unsedated transnasal esophagogastroduodenoscopy in the diagnosis of hypopharyngeal cancer. | this study evaluates the efficacy of unsedated transnasal esophagogastroduodenoscopy (egd) in the diagnosis of hypopharyngeal cancer and screening of esophageal lesions. | 2009 | 18853442 |
| neoadjuvant chemotherapy followed by concurrent hyperfractionated radiation therapy and sensitizing chemotherapy for locally advanced (t3-t4) oropharyngeal squamous cell carcinoma. | radiation therapy (rt) is commonly used in the management of patients with advanced (t3-t4) oropharyngeal squamous cell carcinomas. in recent years, based upon the meta-analyses of randomized trials, chemotherapy administered concurrently with rt (chemoradiotherapy) has become the standard of care. twice-a-day hyperfractionated or accelerated-fractionated rt regimens have been shown in a number of randomized trials to significantly improve the rate of local control compared with conventional onc ... | 2009 | 18853443 |
| comparison of 2% lignocaine with adrenaline and fentanyl, 0.75% ropivacaine and 0.5% levobupivacaine for extension of epidural analgesia for urgent caesarean section after low dose epidural infusion during labour. | low dose local anaesthetic and fentanyl epidural solutions are commonly 'topped-up' for urgent caesarean section. however, the block characteristics associated with newer local anaesthetics such as ropivacaine 0.75% and levobupivacaine 0.5% have not been fully determined. in a randomised double-blinded controlled clinical trial, we compared 2% lignocaine with adrenaline and fentanyl (laf), 0.75% ropivacaine and 0.5% levobupivacaine for extension of low dose epidural analgesia for urgent caesarea ... | 2008 | 18853583 |
| kinetics of olfactory function following endonasal sinus surgery for nasal polyposis. | sinus surgery is known to improve olfactory function in patients with nasal polyposis. however, little is known about the kinetics of this process. | 2008 | 18853868 |
| coarse-graining protein structures with local multivariate features from molecular dynamics. | a multivariate statistical theory, local feature analysis (lfa), extracts functionally relevant domains from molecular dynamics (md) trajectories. the lfa representations, like those of principal component analysis (pca), are low dimensional and provide a reduced basis set for collective motions of simulated proteins, but the local features are sparsely distributed and spatially localized, in contrast to global pca modes. one key problem in the assignment of local features is the coarse-graining ... | 2008 | 18855436 |
| the electron microscopy of developing bacteriophage; growth of t4 in liquid culture. | | 1948 | 18891793 |
| the synthesis of bacterial viruses; the origin of the phosphorus found in the desoxyribonucleic acids of the t2 and t4 bacteriophages. | | 1948 | 18914086 |
| prevalence of hypothyroidism in recurrent pregnancy loss in first trimester. | to determine the frequency of hypothyroidism in women with recurrent pregnancy loss in first trimester in the indian population. | 2008 | 18923214 |
| anaplastic thyroid cancer: prevalence, diagnosis and treatment. | anaplastic thyroid cancer (atc) is a rare aggressive tumor arising from the follicular cells of the thyroid gland (as does well differentiated thyroid cancer, wdtc), but atc cells do not retain any of the biological features of the original follicular cells, such as uptake of iodine and synthesis of thyroglobulin. prognosis is almost invariably fatal. in this article the authors review the pathology, epidemiology, clinical presentation, diagnosis and treatment options of atc. atc incidence typic ... | 2008 | 18923370 |
| the ontogeny of drug metabolizing enzymes and transporters in the rat. | knowledge of the ontogeny of the various systems involved in distribution and elimination of drugs is important for adequate interpretation of the findings during safety studies in juvenile animals. the present study was designed to collect information on plasma concentrations of total protein and albumin, enzyme activity and mrna expression of cytochrome p450 isoenzymes (cyp1a1/2, cyp2b1/2, cyp2e1, cyp3a1/2, and cyp4a1), carboxylesterase and thyroxin glucuronidation (t4-gt) activity in liver mi ... | 2008 | 18926897 |
| [effect of danhong injection on cerebral injury in patients undergoing coronary artery bypass graft operation with extracorporeal circulation]. | to investigate the effect and its possible mechanisms of danhong injection (dhi) on cerebral injury during coronary artery bypass graft (cabg) operation with hypothermic cardiopulmonary bypass (cpb). | 2008 | 18928094 |
| phase ii trial of paclitaxel, carboplatin and gemcitabine in patients with locally advanced carcinoma of the bladder. | this 2-arm phase ii multicenter trial was designed to assess the efficacy and toxicity of neoadjuvant paclitaxel, gemcitabine and carboplatin in patients with invasive bladder cancer. | 2008 | 18930256 |
| quality of life in men with locally advanced adenocarcinoma of the prostate: an exploratory analysis using data from the capsure database. | we present longitudinal quality of life outcomes in a national observational cohort of men with locally advanced prostate adenocarcinoma. | 2008 | 18930270 |
| [a case of long survival in stage iv gastric carcinoma responding to combination treatment with paclitaxel and 5- fluorouracil followed by surgical resection]. | a 62-year-old female with epigastric pain was diagnosed with type 4 gastric cancer upon detailed examination. abdominal computed tomography(ct)revealed metastasis to the paraaortic lymph node and ascites at pelvis, and aspiration cytology of the ascites through vagina was positive(cy1). the clinical stage was determined as t4(panc) n1h0p0cy1m1(lym), cstageiv. three courses of neoadjuvant chemotherapy combined with paclitaxel and 5-fluorouracil( ft therapy)were performed. ft therapy showed a subs ... | 2008 | 18931580 |
| [a case of bilateral t4 breast cancer with different responses to chemotherapy]. | it is recognized that hormone receptors and her2 are important as prognostic factors in breast cancer. moreover, it seems likely that hormone receptors and her2 are important predictive factors for response to chemotherapy in breast cancer. we report a case of bilateral t4 breast cancer with different expression for hormone receptors and her2. the patient was a 67-year-old woman. the stage was t4bn2am0, respectively. the right tumor was negative for hormone receptors and positive for her2, while ... | 2008 | 18931591 |
| repetitive lagging strand dna synthesis by the bacteriophage t4 replisome. | our studies on the t4 replisome build on the seminal work from the alberts laboratory. they discovered essentially all the proteins that constitute the t4 replisome, isolated them, and measured their enzymatic activities. ultimately, in brilliant experiments they reconstituted in vitro a functioning replisome and in the absence of structural information created a mosaic as to how such a machine might be assembled. their consideration of the problem of continuous leading strand synthesis opposing ... | 2008 | 18931782 |
| the history of a developmental stage: metamorphosis in chordates. | metamorphosis displays a striking diversity in chordates, a deuterostome phylum that comprises vertebrates, urochordates (tunicates), and cephalochordates (amphioxus). in anuran amphibians, the tadpole loses its tail, develops limbs, and undergoes profound changes at the behavioral, physiological, biochemical, and ecological levels. in ascidian tunicates, the tail is lost and the head tissues are drastically remodeled into the adult animal, whereas in amphioxus, the highly asymmetric larva trans ... | 2008 | 18932261 |
| characteristics associated with swallowing changes after concurrent chemotherapy and radiotherapy in patients with head and neck cancer. | to define factors that acutely influenced swallowing function prior to and during concurrent chemotherapy and radiotherapy. | 2008 | 18936351 |
| factors associated with anastomotic recurrence after total mesorectal excision in rectal cancer patients. | in patients undergoing total mesorectal excision (tme), the clinical variables most relevant to anastomotic recurrence have not been identified. we evaluated factors associated with anastomotic recurrence in patients undergoing tme and the impact of a reduced distal margin on anastomotic recurrence. | 2009 | 18937260 |
| pathologic upstaging after laparoscopic radical nephrectomy. | accurate tumor staging in renal cancer is critical for prognostic projections, follow-up schedules, clinical trials and potential systemic therapies. we studied patients undergoing laparoscopic radical nephrectomy (lrn) to determine the extent of upstaging on histopathology evaluation and correlated the clinical and pathology staging to determine the factors responsible for upstaging. | 2008 | 18937590 |
| volume determination of oral cavity tumors by 3-dimensional ultrasonography. | with the help of 3-dimensional (3d) ultrasound, the ultrasonographic determination of tumor volumes offers a new view of tumors in the oral cavity. these are classified according to their maximal diameter in tnm classification whereby the possibility exists in the high t category of overestimating small tumors that have spread into surrounding structures, and in the low t of underestimating large volume tumors that do not extend into surrounding structures. | 2008 | 18940495 |
| thyroid hormone resistance. | thyroid hormone resistance (thr) is a rare syndrome of reduced end organ sensitivity. patients with thr have elevated serum free thyroxine (ft4), free triiodothyronine (ft3), but normal or slightly elevated serum thyrotropin values. the characteristic clinical feature is goitre without symptoms and metabolic consequences of thyroid hormone excess. thr can be classified on the basis of tissue resistance into pituitary, peripheral or generalised (both pituitary and peripheral) types. mutations in ... | 2008 | 18940949 |
| the effects of triclosan on puberty and thyroid hormones in male wistar rats. | triclosan (5-chloro-2-(2,4-dichlorophenoxy)phenol) is a potent antibacterial and antifungal compound that is widely used in personal care products, plastics, and fabrics. recently triclosan has been shown to alter endocrine function in a variety of species. the purpose of this study was to determine effects of triclosan on pubertal development and thyroid hormone concentrations in the male rat. weanling rats were exposed to 0, 3, 30, 100, 200, or 300 mg/kg of triclosan by oral gavage from postna ... | 2009 | 18940961 |
| birth delivery mode modifies the associations between prenatal polychlorinated biphenyl (pcb) and polybrominated diphenyl ether (pbde) and neonatal thyroid hormone levels. | developing infants may be especially sensitive to hormone disruption from chemicals including polychlorinated biphenyls (pcbs) and polybrominated diphenyl ethers (pbdes). | 2008 | 18941581 |
| characteristics of colorectal cancer in young patients at an urban county hospital. | colorectal cancer (crc) is a disease primarily affecting an older population. the incidence of crc in young patients has been rising. the purpose of this study was to evaluate the characteristics of crc in an ethnically diverse, young population. two groups of patients with crc (40 years old or younger and 60 years old or older) treated from 1998 to 2005 were retrospectively evaluated. forty-one young patients with crc were identified. hispanics constituted 51 per cent of the young population. f ... | 2008 | 18942625 |
| biocontrol potential of metchnikowia pulcherrima strains against blue mold of apple. | abstract eight strains of metschnikowia pulcherrima isolated over a 4-year period from an unmanaged orchard and selected for their biocontrol activity against blue mold (caused by penicillium expansum) of apples were characterized phenotypically, genetically, and for their biocontrol potential against blue mold on apples. all strains grew well and only differed slightly in their growth in nutrient yeast dextrose broth medium at 1 degrees c after 216 h, but large differences occurred at 0 degrees ... | 2001 | 18943447 |
| dual activity of a viral lysozyme with high efficiency for growth inhibition of erwinia amylovora. | abstract the lysozyme from erwinia amylovora phage phiea1h was investigated for its ability to inhibit growth of bacteria and compared with the lysozyme from escherichia coli phage t4. the assays to measure lysozyme activity included cell lysis and growth inhibition of bacteria. bacterial strains with kanamycin resistance were not affected by lysates containing the phiea1h-enzyme. the titer of micrococcus luteus but not of erwinia amylovora was diminished by cell extracts containing t4 lysozyme. ... | 2004 | 18943701 |
| rhizobacteria-mediated growth promotion of tomato leads to protection against cucumber mosaic virus. | abstract we evaluated combinations of two strains of plant growth-promoting rhizobacteria (pgpr) formulated with the carrier chitosan for the ability to induce growth promotion of tomato plants and resistance to infection by cucumber mosaic virus (cmv). each pgpr combination included gb03 (bacillus subtilis) and one of the following pgpr strains: se34 (b. pumilus), in937a (b. amyloliquefaciens), in937b (b. subtilis), inr7 (b. pumilus), or t4 (b. pumilus). the pgpr combinations formulated with ch ... | 2003 | 18944330 |
| differential induction of grapevine defenses by two strains of botrytis cinerea. | abstract even though botrytis cinerea, the causal agent of gray mold, is a highly variable fungus with strains displaying very different degrees of virulence toward one given host plant species, no study has yet shown any correlation between the lack of aggressiveness of one given strain and its ability to stimulate a defense response from its host. strains of b. cinerea collected from different host plant species were screened for their pathogenicity on grapevine to select two strains with simi ... | 1999 | 18944759 |
| mainly the younger hypothyroid patients are referred to hospital--evidence for referral bias. | studies of hypothyroidism are often based on patients referred to hospital. it is unknown, to what extent such studies are referral biased. thus, the aim of the present study was to evaluate the magnitude of selection bias in a study of patients newly diagnosed with hypothyroidism. | 2009 | 18945587 |
| cyclobutane pyrimidine dimers do not fully explain the mutagenicity induced by uva in chinese hamster cells. | uva generates low levels of cyclobutane pyrimidine dimers (cpds). here we asked the question whether cpds could fully explain the level of mutations induced by uva. relative mutagenicities of uva and uvc were calculated at equal levels of cpds in cell lines, deficient in different aspects of repair. survival and gene mutations in the hprt locus were analyzed in a set of chinese hamster ovary (cho) cell lines, i.e., wild-type, cockayne syndrome b protein-deficient (csb), xrcc3-deficient and xrcc1 ... | 2008 | 18950648 |
| randomized trial of adjuvant thalidomide versus observation in patients with completely resected high-risk renal cell carcinoma. | to evaluate the effect of adjuvant thalidomide on recurrence-free survival (rfs) after nephrectomy for high-risk metastatic renal cell carcinoma (rcc). | 2009 | 18950837 |
| dynamic conformal arc radiotherapy with rectum hollow-out technique for localized prostate cancer. | to report the feasibility of dynamic conformal arc radiotherapy with rectum hollow-out technique (dcat-ho) for localized prostate cancer. | 2009 | 18950880 |
| elective nodal irradiation (eni) in definitive chemoradiotherapy (crt) for squamous cell carcinoma of the thoracic esophagus. | there are some reports indicating that prophylactic three-field lymph node dissection for esophageal cancer can lead to improved survival. but the benefit of eni in crt for thoracic esophageal cancer remains controversial. the purpose of the present study is to retrospectively evaluate the efficacy of elective nodal irradiation (eni) in definitive chemoradiotherapy (crt) for thoracic esophageal cancer. | 2009 | 18952308 |
| overexpression of tierf1 enhances resistance to sharp eyespot in transgenic wheat. | wheat sharp eyespot, primarily caused by a soil-borne fungus rhizoctonia cerealis, has become one of the most serious diseases of wheat in china. in this study, an ethylene response factor (erf) gene from a wheat relative thinopyrum intermedium, tierf1, was characterized further, transgenic wheat lines expressing tierf1 were developed, and the resistance of the transgenic wheat lines against r. cerealis was investigated. southern blotting analysis indicated that at least two copies of the tierf1 ... | 2008 | 18953072 |
| partial resection of persistent left superior vena cava for a t4 lung cancer. | | 2008 | 18954654 |
| anxiety and post-traumatic stress symptoms following wisdom tooth removal. | the purpose of the present study was to determine the psychological impact of wisdom teeth removal and to identify the psychological risk factors for the development of dental anxiety and post-traumatic stress symptoms. participants were 34 consecutive elective patients referred for surgical removal of a wisdom tooth under local anesthesia. frequency of previous distressing dental events and general traumatic life events were assessed at baseline (t1), and emotional distress (pain, state anxiety ... | 2008 | 18954863 |
| spinal epidural lipomatosis--a brief review. | spinal epidural lipomatosis (sel) is a rare disorder characterized by overgrowth of fat in the extradural space, causing compression of the neural elements. it is frequently associated with the administration of exogenous steroids or elevation of endogenous steroids. we present two patients, both with epidural lipamotosis of idiopathic origin. one was 53-year-old man with progressive mid-thoracic and lower limb pain with associated weakness and neurogenic claudication due to thoracic epidural li ... | 2008 | 18954986 |
| effect of pre-operative physiotherapy in patients with end-stage osteoarthritis undergoing hip arthroplasty. | to examine the effect of pre-operative physiotherapy before hip arthroplasty in patients with end-stage hip osteoarthritis. | 2008 | 18955429 |
| computed tomographic morphometry of thoracic pedicles: safety pedicle parameter measurement of the chinese immature thoracic spine. | our objective was to quantify the morphometric characteristics of the pedicles of the chinese immature thoracic spine. a total of 120 patients aged 5-14 years underwent standard thoracic computed tomography (ct). the patients were grouped according to age: group 1 (5-8 years of age), group 2 (9-11 years of age) and group 3 (12-14 years of age). images were reformatted, and multiplanar reconstructions were used to attain images of thoracic pedicles on sagittal, coronal and transverse planes. the ... | 2009 | 18956181 |
| impact of vegf and vegf receptor 1 (flt1) expression on the prognosis of stage iii esophageal cancer patients after radiochemotherapy. | high expression of vascular endothelial growth factor (vegf) is negatively associated with clinical outcome. the prognostic value of vegf receptor 1 (flt1) is unclear. this retrospective study investigated the impact of tumor expression of vegf and flt1 on outcome in 68 stage iii esophageal cancer patients. | 2008 | 18956519 |
| malignant tumors of the nasal cavity and paranasal sinuses: long-term outcome and morbidity with emphasis on hypothalamic-pituitary deficiency. | to evaluate the long-term outcome after surgery and radiotherapy for patients with sinonasal cancer and assess late toxicity, with special emphasis on hypothalamic-pituitary dysfunction. | 2009 | 18963535 |
| outcome prediction after surgery and chemoradiation of squamous cell carcinoma in the oral cavity, oropharynx, and hypopharynx: use of baseline perfusion ct microcirculatory parameters vs. tumor volume. | to assess whether pretreatment perfusion computed tomography (pct) may predict outcome in chemoradiated patients with oral cavity, oropharynx, and hypopharynx squamous cell carcinoma (scca) after surgical excision. | 2009 | 18963541 |
| the prediction for gas chromatographic retention index of disulfides on stationary phases of different polarity. | quantitative structure-retention relationship (qsrr) models for the gas chromatographic (gc) kaváts indices of disulfides on four different polarity stationary phase have been developed. semi-empirical quantum chemical method (am1) implemented in hyperchem 4.0 was employed to calculate a set of molecular descriptors of 50 disulfides. the four stationary phases in the research were: apiezon m, ov-17, triton x-305 and peg-1000. by using multiple linear regression (mlr), we obtained four empirical ... | 2003 | 18968903 |
| [analysis of standard uptake values of 18f-fdg pet/ct in relation to pathological classification and clinical staging of nasopharyngeal carcinoma]. | to explore the relation of the standard uptake values (suv) of 18f-fluorodexygl-gucose (18f-fdg) pet/ct and the pathological classification and clinical staging of nasopharyngeal carcinoma (npc). | 2008 | 18971200 |
| [diagnostic. the new tnm classification for lung cancer]. | the last edition of the tnm-based staging classification of lung cancer is based on the mountain proposal published in 1997. however, due to the multiple methodological problems in the series and in the analysis, an international multidisciplinary panel of experts performed under the auspices of the international association for the study of lung cancer (iaslc) a huge retrospective study, called the iaslc international staging project. the objective was to propose to the uicc and to the ajcc cha ... | 2008 | 18971825 |
| thyroid peroxidase antibodies in pregnant women with type 1 diabetes: impact on thyroid function, metabolic control and pregnancy outcome. | in pregnant women with type 1 diabetes, we evaluated whether the presence of thyroid peroxidase autoantibodies (anti-tpo) was associated with changes in thyroid function, metabolic control and pregnancy outcome. | 2008 | 18972269 |
| rna ligases. | t4 rna ligase 1 catalyzes the atp-dependent covalent joining of single-stranded 5'-phosphoryl termini of dna or rna to single-stranded 3'-hydroxyl termini of dna or rna. t4 rna ligase 2 also catalyzes the joining of a 3'-hydroxyl terminus of rna to a 5'-phosphorylated rna or dna; unlike t4 rna ligase 1, this enzyme prefers double-stranded substrates. a truncated form of t4 rna ligase 2 requires a pre-adenylated substrate for ligation. this unit describes specific reaction conditions, as well as ... | 2008 | 18972386 |
| dna-dependent dna polymerases. | this unit presents characteristics and reaction conditions of the dna-dependent dna polymerases, including e. coli dna polymerase i and its klenow fragment, t4 dna polymerase, native and modified t7 dna polymerase, phi29 dna polymerase, bst dna polymerase, and taq dna polymerase. the unit also provides overviews of other classes of thermophilic dna polymerases used in pcr applications (described fully in unit 15.1), and the rapidly expanding class of lesion-bypass dna polymerases that play a rol ... | 2008 | 18972387 |
| a systematic approach to understand the mechanism of action of the bisthiazolium compound t4 on the human malaria parasite, plasmodium falciparum. | in recent years, a major increase in the occurrence of drug resistant falciparum malaria has been reported. choline analogs, such as the bisthiazolium t4, represent a novel class of compounds with strong potency against drug sensitive and resistant p. falciparum clones. although t4 and its analogs are presumed to target the parasite's lipid metabolism, their exact mechanism of action remains unknown. here we have employed transcriptome and proteome profiling analyses to characterize the global r ... | 2008 | 18973684 |
| effects of supplementation of farta sheep fed hay with sole or mixtures of noug seed meal and wheat bran on feed intake, digestibility and body weight change. | digestibility and feeding trials for 10 and 90 days were conducted using 25 yearling farta rams with a mean body weight (bw) of 16.8 +/- 0.17 kg (mean +/- sd) to study the effects of supplementation with sole or mixtures of noug seed meal (nsm) and wheat bran (wb) on feed intake, digestibility and bw change in farta sheep fed hay. the experimental design was a randomized complete block design. the sheep were arranged in five blocks based on initial bw, and the five treatments were assigned rando ... | 2008 | 18975124 |
| pattern of thyroid function during early pregnancy in women diagnosed with subclinical hypothyroidism and treated with l-thyroxine is similar to that in euthyroid controls. | subclinical hypothyroidism (sch) is associated with a higher miscarriage rate. it is unclear how the thyroid function in sch differs from that in euthyroidism during early pregnancy. we intended to determine the regulation of thyroid function in women with sch receiving constant l-thyroxine (t4) replacement during early pregnancy as compared to euthyroid controls. | 2009 | 18976152 |
| clinical and molecular analysis of thyroid hypoplasia: a population-based approach in southern brazil. | congenital hypothyroidism (ch) is mainly due to developmental abnormalities leading to thyroid dysgenesis (td). td encompasses very distinct morphologic subtypes of disease. this study examined and compared the phenotype in td variants and searched for genetic alterations in sporadic thyroid hypoplasia (th), the most misdiagnosed form of ch. this was a longitudinal study over a 14-year period (1990-2004). | 2009 | 18976153 |
| role of the c-terminus in folding and oligomerization of bacteriophage t4 gene product 9. | bacteriophage t4 gene product 9 (gp9) is a structural protein of baseplate that plays a key role at the beginning of the infection process. biologically active gp9 is a trimer that consists of three domains. it is a convenient model to study folding and oligomerization mechanisms of complex multidomain proteins. the influence of deletions and mutations of several amino acid residues in the c-terminal part of molecule on protein folding, oligomerization, and functional activity has been studied. ... | 2008 | 18976216 |
| fipronil-induced disruption of thyroid function in rats is mediated by increased total and free thyroxine clearances concomitantly to increased activity of hepatic enzymes. | fipronil is a widely used phytosanitary product and insecticide for pets. in the rat, fipronil can disrupt thyroid function by decreasing plasma concentrations of total thyroxine (t4) likely through increased t4 clearance. however, the mechanism of fipronil action on thyroid function remains unclear. the goals of the present study were to evaluate the effects of fipronil on thyroid hormone (th) concentrations and elimination in the rat under well characterized plasma exposure to fipronil and its ... | 2009 | 18977275 |
| squamous cell carcinoma of the hypopharynx: single-institution outcome analysis of a large cohort of patients treated with primary non-surgical approaches. | hypopharyngeal cancers have extensive submucosal spread, high risk of nodal involvement and relatively high propensity of distant metastases. contemporary paradigms for hypopharyngeal cancers aim to maximize loco-regional control while attempting to preserve laryngo-pharyngeal form and function. | 2009 | 18979267 |
| discovery of drug-like inhibitors of an essential rna-editing ligase in trypanosoma brucei. | trypanosomatid rna editing is a unique process and essential for these organisms. it therefore represents a drug target for a group of protozoa that includes the causative agents for african sleeping sickness and other devastating tropical and subtropical diseases. here, we present drug-like inhibitors of a key enzyme in the editing machinery, rna-editing ligase 1 (rel1). these inhibitors were identified through a strategy employing molecular dynamics to account for protein flexibility. a virtua ... | 2008 | 18981420 |
| the anatomic location of pancreatic cancer is a prognostic factor for survival. | pancreatic cancers of the body and tail (bt) appear to have poorer survival compared with head (hd) lesions. we hypothesized that potential disparities in outcome may be related to tumor location. our objective was to examine the relationship between tumor location and survival. | 2008 | 18982154 |
| assembly and glycerol gradient isolation of yeast spliceosomes containing transcribed or synthetic u6 snrna. | studies of rna-protein interactions often require assembly of the rna-protein complex using in vitro synthesized rna or recombinant protein. here, we describe a protocol to assemble a functional spliceosome in yeast extracts using transcribed or synthetic rnas. the in vitro assembled spliceosome is stable and can be isolated by sedimentation through glycerol gradients for subsequent analysis. the protocols describe two procedures to prepare rna: using bacteriophage rna polymerases or ligation of ... | 2008 | 18982283 |
| thyroid activity in patients with major depression. | hypothalamus-pituitary-thyroid (hpt) axis dysfunction has been associated with pathophysiology of major depression. the aim of the study was to determine serum levels of total 3,5,3'-triiodothyronine (t3), total thyroxine (t4) and thyroid-stimulating-hormone (tsh) in patients with major depression and healthy controls. the study included 53 medication-free patients with depression and 49 healthy controls. exclusion criteria for patients was: other axis-i and axis-ii diagnoses, intensive psychoth ... | 2008 | 18982776 |
| two-marker protein profile predicts poor prognosis in patients with early rectal cancer. | the aim of this study was to establish an immunohistochemical protein profile to complement preoperative staging and identify rectal cancer patients at high-risk of adverse outcome. immunohistochemistry was performed on a tissue microarray including 482 rectal cancers for apaf-1, ephb2, mst1, ki67, p53, rhamm, rkip and cd8(+) tumour infiltrating lymphocytes (tils). after resampling of the data and multivariable analysis, the most reproducible markers were combined and prognosis evaluated as stra ... | 2008 | 18985041 |
| immunogenicity and immunoprotection of recombinant peb1 in campylobacter-jejuni-infected mice. | to construct a prokaryotic expression vector carrying campylobacter jejuni peb1a gene and express it in escherichia coli. immunoreactivity and antigenicity of rpeb1 were evaluated. the ability of rpeb1 to induce antibody responses and protective efficacy was identified. | 2008 | 18985818 |
| epidemiologic study on penile cancer in brazil. | to assess epidemiologic characteristics of penile cancer in brazil. | 2008 | 18986562 |
| [application of serum tumor markers and support vector machine in the diagnosis of oral squamous cell carcinoma]. | to investigate the clinical application value of serum tumor markers detection combined with support vector machine (svm) model in the diagnosis of oral squamous cell carcinoma. | 2008 | 18989582 |
| a comparative ph-dissolution profile study of selected commercial levothyroxine products using inductively coupled plasma mass spectrometry. | levothyroxine (t4) is a narrow therapeutic index drug with classic bioequivalence problem between various available products. dissolution of a drug is a crucial step in its oral absorption and bioavailability. the dissolution of t4 from three commercial solid oral dosage forms: synthroid (syn), generic levothyroxine sodium by sandoz inc. (gen) and tirosint (tir) was studied using a sensitive icp-ms assay. all the three products showed variable and ph-dependent dissolution behaviors. the absence ... | 2009 | 18996189 |
| ct staging of colon cancer. | computer tomography (ct) has been the principal investigation in the staging of colon cancers. the information obtained with routine ct has been limited to identifying the site of the tumour, size of the tumour, infiltration into surrounding structures and metastatic spread. the foxtrot trial national cancer research institute (ncri) has been specifically designed to evaluate the efficacy of neoadjuvant treatment in colon cancers by using preoperative chemotherapy with or without an anti-epiderm ... | 2008 | 18996269 |
| chemoradioimmunotherapy with 5-fluorouracil, cisplatin and interferon-alpha in pancreatic and periampullary cancer: results of a feasibility study. | recent studies give rise to the hypothesis, that adjuvant chemoradioimmunotherapy with 5-fluorouracil (5-fu), cisplatin and interferon-alpha (ifn-alpha) might be a possible new treatment of pancreatic cancer in resected patients. we report the up-to-now experience at our institution. | 2008 | 18996727 |
| diagnostic confusion attributable to spurious elevation of both total thyroid hormone and thyroid hormone uptake measurements in the setting of autoantibodies: case report and review of related literature. | to review the effect of thyroid autoantibodies on thyroid function assays and to present a case in which thyroid autoantibodies resulted in spurious assay readings for both total thyroid hormone levels and thyroid hormone uptake measurements. | 2008 | 18996795 |
| serum concentrations of adiponectin and resistin in hyperthyroid graves' disease patients. | this study was undertaken to determine whether serum adiponectin and resistin levels are influenced by hyperthyroidism and autoimmune factors and to find out whether their levels are dependent on the presence of ophthalmopathy. we measured serum concentrations of adiponectin and resistin in 76 patients (63 women, 13 men) with graves' disease (gd) and compared them with levels of the control group which consisted of 30 healthy subjects. patients were separated into two groups according to the pre ... | 2008 | 18997483 |
| hypothyroidism is associated with increased myostatin expression in rats. | besides its key role in the regulation of muscle growth during development, myostatin also appears to be involved in muscle homeostasis in adults, and its expression is upregulated during muscle atrophy. since muscle physiology is greatly influenced by thyroid status, and the myostatin promoter region contains several putative thyroid hormone response elements, in the present study we examined the possible role of thyroid hormones in the regulation of myostatin gene expression. adult male rats w ... | 2008 | 18997488 |
| spinal curvature: comparison of frontal measurements with the spinal mouse and radiographic assessment. | the spinal mouse is an external non-invasive device which measures the spinal shape and mobility of the spine in several planes. the aim of the present study was to evaluate the reliability and the validity of the spinal mouse to assess frontal standing measurements of the spine in a sample of young healthy volunteers. | 2008 | 18997653 |
| critical slowing down in polymer dynamics near the coil-stretch transition in elongation flow. | we present experimental results on relaxation dynamics of lambda-dna and t4 polymer molecules toward a steady state in elongation flow. strong critical slowing down (similar to the well-known effect in continuous phase transitions) in polymer relaxation near the coil-stretch transition (cst) is quantitatively investigated and found to be in good accord with predictions. for polymers with a small number of kuhn segments the maximum of the relaxation time vs the strain rate provides precise inform ... | 2008 | 18999371 |