| transhiatal esophagectomy in a high volume institution. | the optimal operative approach for carcinoma at the lower esophagus and esophagogastric junction remains controversial. the aim of this study was to assess a single unit experience of transhiatal esophagectomy in an era when the use of systemic oncological therapies has increased dramatically. | 2008 | 18715498 |
| radiotherapy timing in 4,820 patients with breast cancer: university of florence experience. | to analyze the relationship between a delay in radiotherapy (rt) after breast-conserving surgery and ipsilateral breast recurrence (br). | 2009 | 18715726 |
| tumor staging of advanced esophageal cancer: combination of double-contrast esophagography and contrast-enhanced ct. | the objective of this study was to compare the diagnostic accuracy of tumor staging in patients with advanced esophageal cancer based on contrast-enhanced ct findings alone with that based on a combination of ct and double-contrast esophagography and to evaluate the relevance of tumor stage to survival rate. | 2008 | 18716105 |
| clinical experience of the importance of daily portal imaging for head and neck imrt treatments. | the purpose of this study was to evaluate patient setup in head and neck imrt using daily portal imaging. at our institution, orthogonal digital portal images are taken daily to check patient positioning prior to head and neck imrt treatment. isocenter misalignments are corrected using a couch shift (3mm action level). therapists also compare the drrs and portal images looking at points more distant from the isocenter, particular in the supraclavicular region, and re-position the patient's shoul ... | 2008 | 18716586 |
| correlation of thyroid and growth hormones to chromosomal instability in egyptian fanconi anemia patients. | fanconi anemia (fa) is a rare inherited genomic instability syndrome and usually associated with endocrine dysfunctions. we aimed to assess the diagnostic standards of chromosomal instability in fa and to correlate the breakage frequency with the severity of endocrinal dysfunctions. | 2008 | 18716735 |
| bodyweight and carcass characteristics of somali goats fed hay supplemented with graded levels of peanut cake and wheat bran mixture. | the experiment was conducted for ninety days of feeding trial at haramaya university, ethiopia using twenty four yearling male somali goats weighing 20.4 +/- 2.02 (mean +/- sd) with the objectives to evaluate the effect of supplementation of peanut cake and wheat bran mixture (3:1) on body weight (bw) gain and carcass characteristics of somali goats. the experiment was arranged with six blocks and four treatments in a randomized complete block design. the treatments were ad libitum feeding of ha ... | 2008 | 18716913 |
| effects of target concentration infusion of propofol and tracheal intubation on qtc interval. | this study was designed to evaluate the effect of target controlled infusion of propofol on qtc interval and tracheal intubation. twenty-five unpremedicated, asa class i or ii patients were selected and target concentration infusion of propofol at 5 microg x ml(-1) was used throughout the study. the qtc interval was measured before anaesthetic induction (baseline, t1), 10 min after propofol infusion (t2), immediately after tracheal intubation (t3), and 1 min after tracheal intubation (t4). the q ... | 2008 | 18717665 |
| immortalized cortical neurons expressing caspase-cleaved tau are sensitized to endoplasmic reticulum stress induced cell death. | it has been previously reported that an asp421 cleaved form of tau is toxic when expressed in cells. the purpose of this study was to understand if, and in what manner, the presence of asp421 cleaved tau in neurons, which is generated by caspase cleavage, might facilitate neuronal death in alzheimer's disease (ad). for these studies we used immortalized cortical neurons that inducibly express either a full-length tau isoform (t4) or an isoform that has been pseudo-truncated at asp421 (t4c3), to ... | 2008 | 18718455 |
| mice lacking the thyroid hormone receptor-alpha gene spend more energy in thermogenesis, burn more fat, and are less sensitive to high-fat diet-induced obesity. | unable to activate brown adipose tissue (bat) thermogenesis, alphat3-receptor-deficient mice (thra-0/0) are cold intolerant. our objective was to investigate the impact on energy economy and mechanisms of the alternate facultative thermogenesis developed. energy expenditure (oxygen and food consumption) is elevated in thra-0/0 mice reared at room temperature. such difference disappears at thermoneutrality (30 c) and expands as ambient temperature becomes colder (p < 0.001). despite eating more, ... | 2008 | 18719022 |
| astigmatism management in cataract surgery with the acrysof toric intraocular lens. | to present clinical data from a single-center prospective clinical trial of the acrysof toric intraocular lens (iol). | 2008 | 18721707 |
| eeg activity in carmelite nuns during a mystical experience. | mystical experiences relate to a fundamental dimension of human existence. these experiences, which are characterized by a sense of union with god, are commonly reported across all cultures. to date, no electroencephalography (eeg) study has been conducted to identify the neuroelectrical correlates of such experiences. the main objective of this study was to measure eeg spectral power and coherence in 14 carmelite nuns during a mystical experience. eeg activity was recorded from 19 scalp locatio ... | 2008 | 18721862 |
| phase i study of preoperative radiation therapy with concurrent infusional 5-fluorouracil and oxaliplatin followed by surgery and postoperative 5-fluorouracil plus leucovorin for t3/t4 rectal adenocarcinoma: ecog e1297. | oxaliplatin is a platinum analog and radiosensitizer active in colorectal cancer. we performed a phase i trial to test the safety and preliminary efficacy of adding oxaliplatin to standard preoperative chemoradiation therapy for rectal cancer. | 2008 | 18722265 |
| protective effects of vitamin e and curcumin on l-thyroxine-induced rat testicular oxidative stress. | present study examines effects of curcumin and vitamin e on oxidative stress parameters, antioxidant defence enzymes and oxidized (gssg) and reduced glutathione (gsh) levels in testis of l-thyroxine (t4)-induced hyperthyroid rats. the oxidative stress in t4-treated rat testis was evident from elevation in oxidative stress parameters such as lipid peroxide and protein carbonyl contents, decrease in superoxide dismutase (sod) and catalase (cat) activities and increase in glutathione peroxidase (gp ... | 2008 | 18723006 |
| characterization of degqvh, a serine protease and a protective immunogen from a pathogenic vibrio harveyi strain. | vibrio harveyi is an important marine pathogen that can infect a number of aquaculture species. v. harveyi degq (degq(vh)), the gene encoding a degq homologue, was cloned from t4, a pathogenic v. harveyi strain isolated from diseased fish. degq(vh) was closely related to the htra family members identified in other vibrio species and could complement the temperature-sensitive phenotype of an escherichia coli strain defective in degp. expression of degq(vh) in t4 was modulated by temperature, poss ... | 2008 | 18723647 |
| biological function of modified nucleotides t(54) and psi(55) of yeast trna(ala). | the 3' half molecule of yeast trna(ala) (nucleotides 36-75) was hybridized with a dna fragment (5'ggaatcgaacc 3') and the hybrid was then digested with e. coli rnase h (from boehringer). the enzyme can specifically cleave the 3' half molecule at the 3' side of nucleotide psi(55), thus a fragment c(36)-psi(55) was prepared. the 3'-terminal t or tpsi of this fragment was removed by one or two cycles of periodate oxidation and beta-elimination. the products were fragments c(36)-t(54) and c(36)-g(53 ... | 1997 | 18726280 |
| [endoscopic surgery in sinonasal inverted papillomas]. | to evaluate the effect and application value of endoscopic resection in sinonasal inverted papillomas. | 2008 | 18727521 |
| reference limits of serum tsh and free t4 are significantly influenced by race and age in an urban outpatient medical practice. | the suitability of tsh reference limits derived from national databases to outpatient practices has not been established. we aimed to determine whether race and age influence the distribution of tsh and free t4 (ft4). | 2009 | 18727705 |
| thyroid hormones directly alter human hair follicle functions: anagen prolongation and stimulation of both hair matrix keratinocyte proliferation and hair pigmentation. | both insufficient and excess levels of thyroid hormones (t3 and t4) can result in altered hair/skin structure and function (e.g. effluvium). however, it is still unclear whether t3 and t4 exert any direct effects on human hair follicles (hfs), and if so, how exactly human hfs respond to t3/t4 stimulation. | 2008 | 18728176 |
| c2 spinal cord stimulation induces dynorphin release from rat t4 spinal cord: potential modulation of myocardial ischemia-sensitive neurons. | during myocardial ischemia, the cranial cervical spinal cord (c1-c2) modulates the central processing of the cardiac nociceptive signal. this study was done to determine 1) whether c2 scs-induced release of an analgesic neuropeptide in the dorsal horn of the thoracic (t4) spinal cord; 2) if one of the sources of this analgesic peptide was cervical propriospinal neurons, and 3) if chemical inactivation of c2 neurons altered local t4 substance p (sp) release during concurrent c2 scs and cardiac is ... | 2008 | 18753268 |
| gross motor functional abilities in preterm-born children with cerebral palsy due to periventricular leukomalacia. | to describe the impact of periventricular leukomalacia (pvl) on gross motor function, data on 59 children (37 males, 22 females) with a gestational age (ga) of 34 weeks or less with cerebral palsy (cp) due to pvl grade i (n=20), ii (n=13), iii (n=25), and iv (n=1) were studied; (mean ga 29 wk 4d [sd 4 wk 6d]; mean birthweight 1318 g [sd 342]). two independent raters used the gross motor function classification system (gmfcs) at four time points: t1, mean corrected age (ca) 9 months 15 days (sd 2 ... | 2008 | 18754918 |
| up-regulation of alpha-catenin is associated with increased lymph node involvement in colorectal cancer. | to investigate the changing pattern of alpha-catenin expression and its relationship to clinical and pathological features of colorectal cancer (crc) patients. | 2008 | 18756598 |
| endoplasmic reticulum chaperone protein grp-78 mediates endocytosis of dentin matrix protein 1. | dentin matrix protein 1 (dmp1), a phosphorylated protein present in the mineral phase of both vertebrates and invertebrates, is a key regulatory protein during biogenic formation of mineral deposits. previously we showed that dmp1 is localized in the nuclear compartment of preosteoblasts and preodontoblasts. in the nucleus dmp1 might play an important role in the regulation of genes that control osteoblast or odontoblast differentiation. here, we show that cellular uptake of dmp1 occurs through ... | 2008 | 18757373 |
| activation of signal transducers and activators of transcription 3 and overexpression of its target gene cyclind1 in laryngeal carcinomas. | constitutive activation of signal transducers and activators of transcription (stat) 3 has been observed in many solid tumors including head and neck squamous cell carcinoma. expression and activation of stat3 in laryngeal carcinoma have not been fully understood. the study aims to investigate the expression and activation of stat3 in laryngeal carcinoma, the relationship between activated stat3 and its downstream target gene cyclind1 and the related clinicopathological factors of activated stat ... | 2008 | 18758380 |
| effect of supplementing urea-treated barley straw with lucerne or vetch hays on feed intake, digestibility and growth of arsi bale sheep. | the study was conducted at sinana agricultural research center, ethiopia to assess the supplementation of graded levels of vetch (vicia dasycarpa 'lana') and lucerne (medicago sativa,' hunter river') hay on feed intake, digestibility and body weight (bw) change of arsi-bale sheep fed urea treated barley straw (utbs). a 7 day- digestibility and a 90 day- feed intake trials were conducted using 28 and 35 sheep, respectively. the experimental design was a randomized complete block design with seven ... | 2009 | 18759063 |
| nongenomic actions of thyroxine modulate intermediate filament phosphorylation in cerebral cortex of rats. | the developmental effects of thyroid hormones (th) in mammalian brain are mainly mediated by nuclear receptors regulating gene expression. however, there are increasing evidences of nongenomic mechanisms of these hormones associated with kinase- and calcium-activated signaling pathways. in this context, the aim of the present work was to investigate the signaling pathways involved in the mechanism of action of th on cytoskeletal phosphorylation in cerebral cortex of 15-day-old male rats. results ... | 2008 | 18760334 |
| recent advances in the treatment of localized rectal cancer. | randomized clinical trials have recently established preoperative chemoradiotherapy as the new standard treatment for patients with localized ct3-t4 or n+ rectal cancer. although its inclusion in the modern multidisciplinary management of patients with rectal cancer makes total eradication of pelvic failure a near reality, it does not yet translate into improved survival. as a result, clinical research should be primarily directed against the micrometastatic process, focusing on integrating inno ... | 2008 | 18765152 |
| nonlinear analysis of the sleep eeg in children with pervasive developmental disorder. | autism is a severe neurodevelopmental disorder with a high rate of epilepsy and subclinical epileptiform activity. high physical connectivity on a microcolumnar level leading to epileptiform activity and low functional informational connectivity are assumed in autism. the aim of this study was to investigate nonlinear eeg brain dynamics in terms of synchronization in a group of children with autism spectrum disorders compared to a control group. we expected a lower degree of synchronization in a ... | 2008 | 18766147 |
| detecting hypothyroidism after treatment for laryngeal or hypopharyngeal carcinomas: a nationwide survey in the netherlands. | a survey to evaluate the management of thyroid function testing was performed in the major institutions treating head and neck cancer in the netherlands. in july 2006, a questionnaire considering laboratory tests, selection of patients, scheme and treatment of hypothyroidism was sent to physicians who treat head and neck cancer patients in 19 hospitals in the netherlands including all eight head and neck centers of the dutch head and neck oncology cooperative group (nederlandse werkgroep hoofd-h ... | 2009 | 18766358 |
| clinical evaluation of thyroid function in racing pigeons (columba livia domestica). | reference values for basal thyroxine (t4) concentrations in racing pigeons are presented for use in clinical pathology. values for basal plasma t4 concentrations in healthy racing pigeons over the four seasons were 6-35 nmol/litre. significant differences were seen between seasons. to differentiate between primary hypothyroidism and other causes of lowered plasma t4 concentrations the optimum dose and sampling times for a tsh stimulation test in this species were determined. a convenient applica ... | 1988 | 18766667 |
| preoperative assessment of hilar cholangiocarcinoma by dual-modality pet/ct. | the purpose of the current study was to evaluate the accuracy of (18)f-fdg pet/ct in staging hilar cholangiocarcinoma. | 2008 | 18767120 |
| pre-operative chemoradiotherapy with uft and leucovorin in patients with advanced rectal cancer: a phase ii study. | the aim this study was to determine the pathologic complete response (pcr) rate defined as tumor regression grade 1 (trg1) and toxicity profile of the combination of high-dose pre-operative radiotherapy and simultaneous uft/leucovorin (lv) in patients with locally advanced rectal cancer. | 2008 | 18768230 |
| the serum levels of 17beta-estradiol, progesterone and triiodothyronine correlate with brown adipose tissue thermogenic parameters during aging. | sex and thyroid hormones are among the factors modulating energy metabolism through regulation of mitochondrial oxidative capacity. brown adipose tissue (bat) in old female rats has been shown to maintain, better than males, the ability to produce heat when exposed to cold. considering the decline that takes place in gonadal and thyroid function during aging, the aim of this work was to test whether the age-related hormonal status may be a potential mediator of the gender differences in bat decl ... | 2008 | 18769061 |
| modeling the nonthyroidal illness syndrome. | to provide an update on the pathogenesis and significance of the nonthyroidal illness syndrome. | 2008 | 18769221 |
| testing the efficiency of aerosol containment during cell sorting. | production of droplets and microdroplets (aerosols) is part of the normal operation of a cell sorter. these aerosols may contain toxic, carcinogenic, or teratogenic fluorophores or known or unknown pathogens from viable biological specimens. most newer models of commercially available instruments incorporate features designed to reduce the production of aerosols and prevent their release into the room. this unit presents two protocols for assessment of aerosol containment on jet-in-air flow sort ... | 2001 | 18770706 |
| putative functional domains of human cytomegalovirus pul56 involved in dimerization and benzimidazole d-ribonucleoside activity. | benzimidazole d-ribonucleosides inhibit dna packaging during human cytomegalovirus (hcmv) replication. although they have been shown to target pul56 and pul89 (the large and small subunits of the hcmv terminase, respectively) their mechanism of action is not yet fully understood. we aimed here to better understand hcmv dna maturation and the mechanism of action of benzimidazole derivatives. | 2008 | 18771048 |
| adjustment of l-t4 substitutive therapy in pregnant women with subclinical, overt or post-ablative hypothyroidism. | maternal hyperthyrotropinaemia is associated with an increased risk of adverse maternal and neonatal outcomes. physiological changes during pregnancy require an increased production of thyroid hormones (or an increase in daily substitutive doses of l-t4 in hypothyroid patients) to meet the maternal and foetal needs. the aim of the study was to evaluate variations of substitutive l-t4 doses that are able to maintain serum tsh between 0.5 and 2.5 mu/l in pregnant women with subclinical- (sh), over ... | 2009 | 18771569 |
| kinetics and thermodynamics of salt-dependent t7 gene 2.5 protein binding to single- and double-stranded dna. | bacteriophage t7 gene 2.5 protein (gp2.5) is a single-stranded dna (ssdna)-binding protein that has essential roles in dna replication, recombination and repair. however, it differs from other ssdna-binding proteins by its weaker binding to ssdna and lack of cooperative ssdna binding. by studying the rate-dependent dna melting force in the presence of gp2.5 and its deletion mutant lacking 26 c-terminal residues, we probe the kinetics and thermodynamics of gp2.5 binding to ssdna and double-strand ... | 2008 | 18772224 |
| the preparation of site-specifically modified riboswitch domains as an example for enzymatic ligation of chemically synthesized rna fragments. | this protocol describes an efficient method for the preparation of riboswitch domains comprising up to approximately 200 nt containing site-specific nucleoside modifications. the strategy is based on enzymatic ligation of chemically synthesized rna fragments. the design of ligation sites strictly follows the criterion that all fragments comprise less than approximately 50 nt. this allows the researcher to rely on custom synthesis services and to utilize the large pool of commercially available, ... | 2008 | 18772873 |
| translational bypassing without peptidyl-trna anticodon scanning of coding gap mrna. | half the ribosomes translating the mrna for phage t4 gene 60 topoisomerase subunit bypass a 50 nucleotide coding gap between codons 46 and 47. the pairing of codon 46 with its cognate peptidyl-trna anticodon dissociates, and following mrna slippage, peptidyl-trna re-pairs to mrna at a matched triplet 5' adjacent to codon 47, where translation resumes. here, in studies with gene 60 cassettes, it is shown that the peptidyl-trna anticodon does not scan the intervening sequence for potential complem ... | 2008 | 18772887 |
| construction of a photo-switchable gene for turning on and off gene expression with light irradiation. | a photoresponsive gfp gene was constructed by attaching a t7 promoter that involves two azobenzene moieties as the photoswitch. the azobenzene moieties tethered on d-threoninol were inserted precisely into the sequence of t7 promoter at two positions in the nontemplate strand. by using azobenzene-tethered dna as one primer, azobenzene was attached to gfp gene after pcr amplification. however, a single-stranded overhang involving azobenzene was formed because primer extension stopped at the posit ... | 2008 | 18776232 |
| feed intake, digestibility, body weight and carcass parameters of afar rams fed tef (eragrostis tef) straw supplemented with graded levels of concentrate mix. | the experiment was conducted at alamata agricultural research center, ethiopia using 20 afar rams with an initial body weight (bw) of 18.2 +/- 1.76 (mean +/- sd) kg. the objectives were to study the effect of supplementation with concentrate mix consisting of wheat bran (wb), noug seed cake (nsc) and sesame seed cake (ssc) at the ratio of 2:1:1 on dry matter (dm) basis, respectively on feed intake, digestibility, bw gain and carcass parameters of afar rams fed tef (eragrostis tef) straw basal di ... | 2009 | 18777140 |
| intraoperative radioisotope injection for sentinel lymph node biopsy. | preoperative injection of technetium-99 m sulfur colloid (tc-99) in the nuclear medicine department for localizing sentinel lymph nodes (slns) can be extremely painful for the patient. the difficulties in scheduling and the delay in starting surgery can be frustrating for the patient and the surgeon. we hypothesized that intraoperative injection facilitated by the subareolar technique would obviate the problems associated with preoperative injection. | 2008 | 18777194 |
| label-free electrochemical monitoring of dna ligase activity. | this study presents a simple, label-free electrochemical technique for the monitoring of dna ligase activity. dna ligases are enzymes that catalyze joining of breaks in the backbone of dna and are of significant scientific interest due to their essential nature in dna metabolism and their importance to a range of molecular biological methodologies. the electrochemical behavior of dna at mercury and some amalgam electrodes is strongly influenced by its backbone structure, allowing a perfect discr ... | 2008 | 18778033 |
| uterotrophic assay, hershberger assay, and subacute oral toxicity study of 3-amino-1,2,4-triazole based on the organization for economic co-operation and development draft protocols. | we performed a uterotrophic assay, the hershberger assay, and the 28-day repeated-dose toxicity study (enhanced oecd test guideline no. 407) of 3-amino-1,2,4-triazole based on the oecd draft protocols. in the uterotrophic assay, female sd rats were subcutaneously injected with the chemical at doses of 0, 100, 300, and 1,000 mg/kg on each of 3 days from postnatal day 20 to day 22, and no changes were observed. in the hershberger assay, the test chemical was orally administered at doses of 0, 40, ... | 2009 | 18779953 |
| use of experimental crystallographic phases to examine the hydration of polar and nonpolar cavities in t4 lysozyme. | there is conflicting evidence as to whether cavities in proteins that are nonpolar and large enough to accommodate solvent are empty or are occupied by disordered water molecules. here, we use multiple-wavelength x-ray data collected from crystals of the selenomethionine-substituted l99a/m102l mutant of t4 lysozyme to obtain a high-resolution electron density map free of bias that is unavoidably associated with conventional model-based structure determination and refinement. the mutant, l99a/m10 ... | 2008 | 18780783 |
| refolding of proteins from inclusion bodies is favored by a diminished hydrophobic effect at elevated pressures. | the application of high hydrostatic pressure is an effective tool to promote dissolution and refolding of protein from aggregates and inclusion bodies while minimizing reaggregation. in this study we explored the mechanism of high-pressure protein refolding by quantitatively assessing the magnitude of the protein-protein interactions both at atmospheric and elevated pressures for t4 lysozyme, in solutions containing various amounts of guanidinium hydrochloride. at atmospheric pressure, the prote ... | 2009 | 18781701 |
| chemotherapy in addition to preoperative radiotherapy in locally advanced rectal cancer - a systematic overview. | the value of chemotherapy with radiotherapy has been explored in recent randomised clinical trials in locally advanced rectal cancer (larc). an overview of these trials was made together with a discussion of what constitutes larc. although imaging is required for adequate staging of primary rectal cancer, the term 'locally' advanced has no consistent definition and has been used differently in the trials. three large randomised trials, however, in different subsets, show that radiochemotherapy ( ... | 2008 | 18782078 |
| advanced-stage renal cell carcinoma treated by radical nephrectomy and adjacent organ or structure resection. | to examine the effect of radical nephrectomy (rn) with adjacent organ and structure resection on survival, as invasion of adjacent organs in patients with renal cell carcinoma (rcc) is rare. | 2009 | 18782305 |
| revised phylogenetic relationships among herpesviruses isolated from sturgeons. | initial phylogenetic comparisons based on a region of the dna polymerase of seven herpes-like viruses found in sturgeons in north america and europe indicated the presence of three distinct clades. a revised phylogenetic analysis of the same viruses, based on corrected dna polymerase sequences and newly obtained sequence data from the putative atp subunit of the terminase gene, indicate only two clades. these two clades correspond to the historical designations given to these herpes-like viruses ... | 2008 | 18783130 |
| gene expression profiles associated with advanced pancreatic cancer. | few studies have addressed the expression profiles associated with progression of pancreatic cancer to advanced disease. towards this end, we performed expression profiling of a series of normal pancreas, pancreatitis and cancer tissues representing early stage resected pancreatic cancers (stages pt2/t3), late stage unresectable cancers (stage pt4) and matched metastases to a variety of organ sites. microarray data was analyzed using linear modeling of microarray data (limma), and differentially ... | 2008 | 18784821 |
| thyroxine treatment stimulated ovarian follicular angiogenesis in immature hypothyroid rats. | the development of mature ovarian follicles is greatly dependent on healthy thecal angiogenesis. recent experimental evidence showed that thyroxine (t4) treatment promoted ovarian follicle development in immature hypothyroid (rdw) rats. however, an involvement of thyroid hormone in ovarian follicular angiogenesis has not yet been demonstrated. by morphological and molecular approaches, the present studies demonstrated that antral follicles in untreated, t4- or equine chorionic gonadotropin (ecg) ... | 2008 | 18785121 |
| microbial levan in the diet of labeo rohita hamilton juveniles: effect on non-specific immunity and histopathological changes after challenge with aeromonas hydrophila. | a 60-day feeding trial was conducted to study the immuno-protective effect of microbial levan on labeo rohita juveniles challenged with aeromonas hydrophila. six purified diets were prepared with different levels of microbial levan: control (no levan), t1 (basal + 0.25%), t2 (basal + 0.50%), t3 (basal + 0.75%), t4 (basal + 1%) and t5 (basal + 1.25%), fed to six groups of fish in triplicate. among the treatment groups the haemoglobin content and total leucocyte count were increased with a dietary ... | 2008 | 18786027 |
| melanoma in organ transplant recipients: clinicopathological features and outcome in 100 cases. | organ transplant recipients have a higher incidence of melanoma compared to the general population but the prognosis of this potentially fatal skin cancer in this group of patients has not yet been established. to address this, we undertook a multicenter retrospective analysis to assess outcome for 100 melanomas (91 posttransplant and 9 pretransplant) in 95 individuals. data were collected in 14 specialist transplant dermatology clinics across europe belonging to the skin care in organ transplan ... | 2008 | 18786232 |
| clinical inquiries: which lab tests are best when you suspect hypothyroidism? | thyroid-stimulating hormone (tsh) level is the preferred test for initial evaluation of suspected primary hypothyroidism (strength of recommendation [sor]: expert opinion). if tsh is abnormal, a free thyroxine (t4) level will further narrow the diagnosis. obtain a triiodothyronine (t3) level if tsh is undetectable and free t4 is normal. when assessing the adequacy of replacement therapy in primary hypothyroidism, the tsh is the most important parameter to monitor (sor: expert opinion). because t ... | 2008 | 18786337 |
| large induction of type iii deiodinase expression after partial hepatectomy in the regenerating mouse and rat liver. | the deiodinase types 1 (d1) and 2 (d2) catalyze the activation of t4 to t3, whereas type 3 deiodinase (d3) catalyzes the inactivation of t3 and t4. d3 plays a key role in controlling thyroid hormone bioavailability. it is highly expressed during fetal development, but also in other processes with increased cell proliferation, e.g. in vascular tumors. because tissue regeneration is dependent on cellular proliferation and is associated with activation of fetal genes, we evaluated deiodinase activi ... | 2009 | 18787028 |
| thyroid volume is associated with family history of thyroid disease in pregnant women with adequate iodine intake: a cross-sectional study in southern brazil. | maternal euthyroidism is important for fetal neural development. for this reason, adequate iodine nutrition during pregnancy is an important public health objective and should be periodically revised. the objective of this study was to measure urinary iodine (ui) excretion and the factors associated with thyroid volume (tv), in a group of healthy pregnant women in southern brazil, to evaluate iodine nutrition. the median ui of the 147 women was 224 microg/l (p25=164 microg/l and p75=286 microg/l ... | 2008 | 18787379 |
| children with congenital hypothyroidism: long-term intellectual outcome after early high-dose treatment. | we aim to determine long-term intellectual outcome of adolescents with early high-dose treated congenital hypothyroidism (ch). sixty-three prospectively followed children with ch were assessed at age of 14 y with the wechsler intelligence scale for children-revised and compared with 175 healthy controls. median age at onset of treatment was 9 d (range 5-18 d) and median starting dose of levothyroxine (l-t4) was 14.7 microg/kg/d (range 9.9-23.6 microg/kg/d). full-scale intelligence quotient (iq) ... | 2009 | 18787501 |
| reduction of blood coagulation and monocyte-platelet interaction following the use of a minimal extracorporeal circulation system (synergy) in coronary artery bypass grafting (cabg). | cardiovascular surgery with cardiopulmonary bypass (cpb) induces activation of blood coagulation and systemic inflammation involved in post-operative complications. our study evaluated the impact of the minimal extracorporeal circulation (mini-cpb) system (synergy, sorin group) on these functional aspects. twenty patients were randomly assigned to standard cpb (n = 10) or to synergy (n = 10). platelet expression of pac-1, and monocyte/granulocyte-platelet conjugates were evaluated by flow cytome ... | 2008 | 18788218 |
| axillary recurrences after negative sentinel lymph node biopsy under local anaesthesia for breast cancer: a follow-up study after 5 years. | sentinel lymph node biopsy (slnb) is accepted as a standard surgical staging procedure for determining the tumour status of the regional lymph nodes. until september 2000 we performed slnb in general anaesthesia. since 1999, after validation of the slnb concept, axillary dissection was omitted in sln-negative patients. this study presents our data after slnb under local anaesthesia after a follow-up of at least 5 years. | 2009 | 18789841 |
| the effect of genetic variation in the type 1 deiodinase gene on the interindividual variation in serum thyroid hormone levels: an investigation in healthy danish twins. | genetic factors have a considerable influence on serum thyroid hormone levels. the c785t and a1814g polymorphisms, located in the 3' untranslated region of the type 1 deiodinase (d1) gene have been associated with serum ft4 and rt3 levels. | 2009 | 18793344 |
| early clinical results from chemoradiation with 5-fluorouracil and oxaliplatin for locally advanced rectal cancer. | preoperative chemoradiation with 5-fluorouracil (5-fu) has improved local control and resectability in patients with locally advanced rectal adenocarcinoma. the possible benefit of adding oxaliplatin is being investigated. we present background on the use of oxaliplatin as well as institutional experience assessing treatment tolerability and early outcome data. | 2008 | 18794065 |
| in vitro disc pressure profiles below scoliosis fusion constructs. | biomechanical human cadaveric study comparing straight and scoliotic spines with healthy and degenerated l4/5 discs. | 2008 | 18794754 |
| iodine in early pregnancy--is there enough? | to evaluate the iodine status of patients in early pregnancy and its dependence on level of thyroid-stimulating hormone (tsh). | 2008 | 18795082 |
| extradural giant multiloculated arachnoid cyst causing spinal cord compression in a child. | spinal extradural arachnoid cysts are rare expanding lesions in the spinal canal. enlargement may cause progressive signs and symptoms caused by spinal cord compression. they are associated with trauma, surgery, arachnoiditis, and neural tube defects. most nontraumatic spinal extradural arachnoid cysts are thought to be congenital. | 2008 | 18795482 |
| prognostic value of the detection of lymph node micrometastases in colon cancer. | a study is made of the clinical repercussions of occult metastases-micrometastases (mms+)-or isolated tumour cells (itcs+) in the lymph nodes of patients with stage iia and iib colon adenocarcinoma initially considered as corresponding to n0. | 2008 | 18796374 |
| [hgh treatment impact on adrenal and thyroid functions]. | somatotrophic status is a major determinant of both thyrotrophic and corticotrophic axis. in growth hormone deficient patients, somatotrophic replacement increases the conversion rate of the inactive form of the thyroid hormone (t4) to its active form (t3), whereas the same replacement induces the conversion of cortisol, which is hormonally active, in cortisone, its inactive form. this review details the effects of gh on these two hormonal axis, possible mechanisms and clinical implications for ... | 2008 | 18797597 |
| the correlation between the method of sympathetic ablation for palmar hyperhidrosis and the occurrence of compensatory hyperhidrosis: a review. | upper dorsal sympathectomy achieves excellent long-term results in the treatment of primary palmar hyperhidrosis. compensatory hyperhidrosis (chh) remains an unexplained sequel of this treatment, attaining in a small percentage of cases disastrous proportions. it has been claimed that lowering the level of sympathectomy (from t2 to t3 and even t4), substituting resection by other means of ablation, and limiting its extend reduce the occurrence of this sequel. this review was designed to evaluate ... | 2008 | 18797962 |
| serum antithyroid antibodies in female patients with chronic urticaria. | to determine the frequencies of serum antithyroglobulin and antimicrosomal autoantibodies in female patients with chronic urticaria, and the association between thyroid autoantibodies and chronic urticaria, if any. | 2008 | 18798586 |
| preoperative staging of mesothelioma by 18f-fluoro-2-deoxy-d-glucose positron emission tomography/computed tomography fused imaging and mediastinoscopy compared to pathological findings after extrapleural pneumonectomy. | extrapleural pneumonectomy (epp) in mpm may be confined with both morbidity and mortality and careful preoperative staging identifying resectable patients is important. staging is difficult and the accuracy of preoperative ct scan, 18f-fdg pet/ct scan (pet/ct), and mediastinoscopy is unclear. the objectives were to compare these staging techniques to each other and to surgical-pathological findings. | 2008 | 18799318 |
| sensory neuron sodium current requires nongenomic actions of thyroid hormone during development. | development of the embryonic nervous system requires thyroid hormone. however, the underlying mechanisms and targets of thyroid hormone action are not well defined. to identify embryonic roles for thyroid hormone we tested for effects on a key neuronal trait, voltage-gated sodium current (i(na)), in the zebrafish model system. we recorded from rohon-beard sensory neurons (rbs) using whole cell voltage-clamp methods. here, we provide in vivo evidence for thyroid hormone regulation of i(na). chron ... | 2008 | 18799597 |
| type 2 iodothyronine deiodinase is essential for thyroid hormone-dependent embryonic development and pigmentation in zebrafish. | despite the known importance of thyroid hormones (ths) in vertebrate growth and development, the role of tissue-specific th activation in early embryogenesis remains unclear. we therefore examined the function of type 2 iodothyronine deiodinase (d2), one of the two tissue-specific enzymes catalyzing the conversion of t4 to t3, in developing zebrafish embryos (danio rerio). microinjection of early embryos with antisense oligonucleotides targeting either the d2 translation start site or the splice ... | 2009 | 18801906 |
| recombinant human tsh increases the efficacy of a fixed activity of radioiodine for treatment of multinodular goitre. | high doses of (131)i are usually needed in the treatment of multinodular goitre (mng) for effective thyroid volume (tv) reduction. recombinant human thyroid-stimulating hormone (rhtsh) is an adjuvant to enhance (131)i uptake, allowing a decrease in radiation activity and enhancing (131)i efficacy. | 2009 | 18803554 |
| quality of life changes and clinical outcomes in thyroid cancer patients undergoing radioiodine remnant ablation (rra) with recombinant human tsh (rhtsh): a randomized controlled study. | recombinant human tsh (rhtsh) has become the modality of choice for radioiodine remnant ablation (rra) in low-risk thyroid cancer patients. | 2009 | 18803678 |
| results of primary surgery with t4 non-small cell lung cancer during a 25-year period in a single center: the benefit is worth the risk. | the purpose of this study was to assess operative mortality, morbidity, and long-term results of patients with surgically resected t4 non-small cell lung carcinoma. | 2008 | 18805134 |
| the impact of lymph node station on survival in 348 patients with surgically resected malignant pleural mesothelioma: implications for revision of the american joint committee on cancer staging system. | the propensity of malignant pleural mesothelioma to metastasize to n1 or n2 nodes and their corresponding prognostic value is unclear. the american joint committee on cancer staging system groups n1 and n2 disease together as stage iii. the goal of this study was to define the prognostic value of specific nodal stations. | 2008 | 18805259 |
| effect of dena induced hepatocarcinogenesis on neuroendocrine levels in male rats. | hepatocarcinogenesis was induced in sprague dawley rats by injecting diethylnitrosamine (dena); 150 mg/kg body weight, ip, a well known liver carcinogen and a mutagenic agent. concurrent with the induction of hepatocarcinoma, psychological stress was also elicited from the changes in brain neurotransmitters. noradrenaline and dopamine, the neurotransmitters of sympathetic system were estimated from the whole brain and corresponding hormones t3, t4 and prolactin were estimated from the blood of s ... | 2008 | 18807752 |
| influence of correction objectives on the optimal scoliosis instrumentation strategy: a preliminary study. | in three recent studies we have shown how different correction objectives from a group of experienced spine surgeons add to the variability in ais instrumentation strategies. this study examined the effect of correction objectives of three surgeons on the optimal instrumentation strategy. an optimization method using six instrumentation design parameters (e.g. limits of the instrumented segment, number, type and location of implants and rod shape) that were manipulated in a uniform experimental ... | 2008 | 18810011 |
| comparison of the kyphosis angle evaluated by video rasterstereography (vrs) with x-ray measurements. | surface topography evaluations are prone to technical errors due to postural sway of the patients measured. the technical error of lateral deviation (rms) and surface rotation (rms) may vary between 15 and 20%, while the kyphosis angle (ip-itl) has a technical error of only 5% (2,5 degrees), which is comparable to the x-ray measurement. purpose of this study was to investigate the hypothesis that video rasterstereography can be used for prognostication of a kyphosis patient. | 2008 | 18810015 |
| basal cell carcinoma of the nose: an australian and new zealand radiation oncology patterns-of-practice study. | patients with a basal cell carcinoma (bcc) of the nose may be recommended radiotherapy (rt) with a wide variation in techniques and prescribed dose fractionation schedules between clinicians. the aim of this study was to ascertain variability in the patterns of practice among australian and new zealand radiation oncologists (ros) when treating bcc arising on the nose. a postal survey was sent to 222 practising anz ros detailing 12 different clinical scenarios of a bcc arising on the nose. the tr ... | 2008 | 18811764 |
| thyroid autoimmunity in patients with alopecia areata. | alopecia areata (aa) is a common form of localized, non-scarring hair loss. it is characterized by the loss of hair in patches, total loss of scalp hair (alopecia totalis), or total loss of body hair (alopecia universalis). the etiopathogenesis of the disease is still unclear, but there is evidence that autoimmunity and endocrine dysfunction may be involved. the aim of this study was to determine whether aa is statistically associated with thyroid autoimmunity. in this retrospective epidemiologi ... | 2008 | 18812059 |
| role of loops in the guanine quadruplex formation by dna/rna hybrid analogs of g4t4g4. | cd spectroscopy, gel electrophoresis and absorption-based thermal stability were used to analyze quadruplex formation of rna and rna/dna hybrid analogs of the deoxyoligonucleotide g4t4g4, which forms a well-characterized basket-type quadruplex. all rna-containing dodecamers, g4u4g4, g4u4g4 and g4t4g4 (rna lower-case, dna capital letters), formed parallel, namely tetramolecular quadruplexes in na+-containing solutions. the u4 loop forced dna tetrads into the same conformation as adopted by g4u4g4 ... | 2008 | 18812187 |
| role of three-dimensional anorectal ultrasonography in the assessment of rectal cancer after neoadjuvant radiochemotherapy: preliminary results. | three-dimensional anorectal ultrasound (3-daus) scanning provides accurate information on tumor size and its relation to the anal muscles. the purpose of this study was to evaluate the ability of 3-daus to assess response to radiochemotherapy (rct) for rectal cancer by comparing 3-daus images to pathological findings. | 2009 | 18813985 |
| accuracy of endoanal ultrasound in the follow-up assessment for squamous cell carcinoma of the anal canal treated with radiochemotherapy. | radiochemotherapy has largely replaced surgery in the treatment for squamous cell cancer of the anal canal. transanal ultrasonography is well documented as an important investigation method in the management of anal carcinoma. this study aimed to evaluate the accuracy of endoanal ultrasound in the study of the postradiation findings and to distinguish between postradiation fibrosis, residual tumor, and local recurrence. | 2009 | 18813993 |
| effects of prenatal exposure to organochlorines on thyroid hormone status in newborns from two remote coastal regions in québec, canada. | several prospective studies have revealed that prenatal exposure to polychlorinated biphenyls (pcbs) and other organochlorine compounds (ocs) affect neurodevelopment during infancy. one of the mechanisms by which pcbs might interfere with neurodevelopment is a deficit in thyroid hormone (th) concentrations. | 2008 | 18814871 |
| the epidemiology of bladder cancer in russia. | this study assessed the epidemiology of bladder cancer in russia. the available publications in russian were analysed, as well as information from the database of n. n. blokhin cancer research center, accumulating non-uniform data from different cities and regions of russia. in 2006 there were 68 129 patients with bladder cancer in russia, accounting for 2.8% of all cancer cases, with unknown proportions of males and females. in the same year 11 973 new bladder cancer cases were diagnosed, with ... | 2008 | 18815913 |
| molecular alterations associated with bladder cancer initiation and progression. | bladder cancer is the fifth most commonly diagnosed non-cutaneous solid malignancy, and the second most commonly diagnosed genitourinary malignancy amongst people living in the united states, where it is estimated that more than 61,000 new cases of bladder cancer will be diagnosed in the year 2008. approximately 90% of malignant tumors arising in the urinary bladder are of epithelial origin, the majority being transitional cell carcinomas. early stage bladder tumors have been classified into two ... | 2008 | 18815930 |
| structural and thermodynamic characterization of t4 lysozyme mutants and the contribution of internal cavities to pressure denaturation. | using small-angle x-ray scattering (saxs) and tryptophan fluorescence spectroscopy, we have identified multiple compact denatured states of a series of t4 lysozyme mutants that are stabilized by high pressures. recent studies imply that the mechanism of pressure denaturation is the penetration of water into the protein rather than the transfer of hydrophobic residues into water. to investigate water penetration and the volume change associated with pressure denaturation, we studied the solution ... | 2008 | 18816066 |
| hepatocyte growth factor (hgf) and the satellite cell response following muscle lengthening contractions in humans. | the time-courses of satellite cell (sc) activation and protein expression of hepatocyte growth factor (hgf), hgf activator (hgfa), hgfa inhibitor-1 (hai-1), and hgfa inhibitor-2 (hai-2) in human skeletal muscle, as well as serum hgf following a single bout of muscle lengthening contractions, were determined. eight recreationally active participants were recruited for the study. subjects performed 300 lengthening contractions involving the quadriceps femoris muscles of a single leg at a fixed vel ... | 2008 | 18816607 |
| effect of silymarin on metabolic factors of food-restricted over conditioned wistar rats. | this study was conducted to evaluate the changes in serum metabolic factors of over conditioned pregnant rats treated with silymarin in food restriction condition. sixty pregnant wistar rats were divided into five equal groups. all rats received high energy diet before treatments. control group were fed ad libitum (non-fr). rats in other groups received 50% of the food intake of non-fr group and served as food-restricted (fr) groups. three of five fr groups received 150, 200 and 400 mg kg(-1) si ... | 2008 | 18817226 |
| an analysis on quality, colour, tissue texture, total soluble solid content, titratable acidity and ph of santol fruits (sandoricum koetjape burm. f.) merr. pui fai cultivar, grown in northern thailand. | this laboratory experiment was carried out at the department of agricultural technology, mahasarakham university, northeast thailand during june to october 2007. the experiment aimed to search for the most appropriate harvesting age of fruits of santol orchard plants with respect to colour, tissue texture, total soluble solid content, titratable acidity and ph of santol fruits. a randomised complete block design (rcbd) with four replications was used. each replication consisted of 10 fruits, thu ... | 2008 | 18817267 |
| total synthesis of (+)-cassaine via transannular diels-alder reaction. | a full account of the total synthesis of (+)-cassaine ( 1) using the transannular diels-alder (tada) reaction as the pivotal construction is described. the strategy began from evans' oxazolidine 8, the only chiral source used for the total stereochemical outcome of the target molecule. the key intermediate 3 was obtained from 8 in 10 steps in 40% overall yield. following extensive optimization, the coupling of 3 on both ends with another densely functional partner 2 followed by tada reaction on ... | 2008 | 18817389 |
| [extradural spinal meningioma: case report]. | we report a case of purely extradural spinal meningioma and discuss the potential pitfalls in differential diagnosis. | 2009 | 18817937 |
| co-expression of igf-1 family members with myogenic regulatory factors following acute damaging muscle-lengthening contractions in humans. | muscle regeneration following injury is dependent on the ability of muscle satellite cells to activate, proliferate and fuse with damaged fibres. this process is controlled by the myogenic regulatory factors (mrf). little is known about the temporal relation of the mrf with the expression of known myogenic growth factors (i.e. igf-1) in humans following muscle damage. eight subjects (20.6 +/- 2.1 years; 81.4 +/- 9.8 kg) performed 300 lengthening contractions (180 deg s(-1)) of their knee extenso ... | 2008 | 18818249 |
| [apoptosis, proliferation and spleen histomorphometry of adult female rats with thyroid and ovarian hypofunction]. | apoptosis, proliferation and histomorphometry of spleen were investigated in ovariectomized and non-ovariectomized adult wistar rats maintained in hypothyroidism induced by daily administration of propylthiouracil (ptu) during 120 days. two groups ovariectomized euthyroid and non-ovariectomized euthyroid were used as controls. plasma was collected for free t4 dosage and the spleen for histomorphometry analysis, apoptosis index and the immunohistochemistry expression of caspase 3 and cdc47. value ... | 2008 | 18820815 |
| regulation of the spovm gene of bacillus subtilis. | the spovm gene of bacillus subtilis codes for a 26 amino-acid peptide that is essential for sporulation. analysis of the expression of the spovm gene revealed that wild-type cells started to synthesize a spovm-specific transcript at t2, whereas the spovm peptide accumulated at t4. both the transcript and the peptide were absent from an spovm knockout strain. the 5' untranslated region of the spovm transcript increased expression of spovm. possible regulation mechanisms are discussed. | 2008 | 18820968 |
| determination of (+)-3,3',5,5'-tetraiodo-l-thyronine (l-t4) in serum and pharmaceutical formulations using a sequential injection analysis/immunosensor system. | a sequential injection analysis/immunosensor system is proposed for the analysis of thyroxine (l-t4) in serum and in pharmaceutical formulations with a rate of 75 samples/hour. the immunosensor design is based on the physical immobilization of anti-l-t4 in carbon paste. the working concentration range of the immunosensor in the sequential injection analysis system is between 36 and 1080 ng/ml with a limit of detection of 24.6 ng/ml. the system is very reliable and very easy to design and operate ... | 2008 | 18821409 |
| correlation between magnetic resonance imaging and histopathological tumor response after neoadjuvant chemotherapy in breast cancer. | to evaluate the accuracy of magnetic resonance imaging in assessing tumor response following neoadjuvant chemotherapy in patients with locally advanced breast cancer. | 2008 | 18822682 |
| [intervening and therapeutic effect of cordyceps mycelia extract on liver cirrhosis induced by dimethylnitrosamine in rats]. | to explore the intervening and therapeutic effect of cordyceps mycelia extract (cme) on liver cirrhosis induced by dimethylnitrosamine (dmn) in rats. | 2008 | 18822912 |
| surgical outcomes and survival after multiorgan resection for locally advanced gastric cancer. | multiple organ resection for locally advanced (assumed t4) gastric cancer is associated with high morbidity and mortality. our aim was to evaluate the efficacy of these surgeries with regard to surgical morbidity, mortality, and survival. | 2009 | 18823618 |
| thoracic spinal cord compression by intramedullary hamartomatous tissue in a young boy: case report. | spinal cord hamartomas are a rare occurrence characterized by well- differentiated mature elements located in an irregular position in the spinal cord. | 2008 | 18824961 |