| the role of proteases in the differentiation of acanthamoeba castellanii. | proteases are significant determinants of protozoan pathogenicity and cytolysis of host cells. however, there is now growing evidence of their involvement in cellular differentiation. acanthamoeba castellanii of the t4 genotype elaborates a number of proteases, which are inhibited by the serine protease inhibitor phenylmethylsulphonyl fluoride. using this and other selective protease inhibitors, in tandem with sirna primers, specific to the catalytic site of acanthamoeba serine proteases, we dem ... | 2008 | 18616591 |
| rectal cancer in young adults: a series of 102 patients at a tertiary care centre in india. | rectal cancer in young patients is uncommon. there is little information on rectal cancer in young adults in india. the aim of this study was to determine the relative incidence of rectal cancer in young patients in india and identify any differences in histological grade and pathological stage between younger and older cohorts. | 2009 | 18616736 |
| spinal cord compression by a solitary metastasis from a low grade leydig cell tumour: a case report and review of the literature. | leydig tumour is rare and there are only three cases with metastatic disease reported. | 2008 | 18616814 |
| growth, feed efficiency and blood profile of buffalo calves consuming high levels of fluoride: growth and blood metabolites in buffaloes fed high fluoride. | twelve male buffalo calves of 10 to 12 months of age were divided into 3 groups of four each. they were fed wheat straw+concentrate mixture +3 kg greens. the chemical composition of the diet was same in all the three groups except fluoride which was added (as naf) in concentrate mixture of group b and c to make the final fluoride concentration 30 ppm and 60 ppm respectively. the animals were kept on scheduled diet for a period of 90 days. body weights were recorded at the start of the experiment ... | 2009 | 18618286 |
| upstaging benefits and accuracy of sentinel lymph node mapping in colorectal adenocarcinoma nodal staging. | sentinel lymph node (sln) mapping is an additional method for improving colorectal cancer nodal staging. the purpose of the study was to define the method's accuracy in nodal staging, its upstaging benefits and to identify the predictive factors for its failure. | 2008 | 18618578 |
| genetically engineered charge modifications to enhance protein separation in aqueous two-phase systems: electrochemical partitioning. | we have examined the effect of genetically engineered charge modifications on the partitioning behavior of proteins in dextran/polyethylene glycol two-phase systems containing potassium phosphate. by genetically altering a protein's charge, the role of charge on partitioning can be assessed directly without the need to modify the phase system. the charge modifications used are of two types: charged tails of polyaspartic acid fused to beta-galactosidase and charge-change point mutations of t4 lys ... | 1994 | 18618679 |
| hormone affinity and fibril formation of piscine transthyretin: the role of the n-terminal. | transthyretin (ttr) transports thyroid hormones (ths), thyroxine (t4) and triiodothyronine (t3) in the blood of vertebrates. th-binding sites are highly conserved in vertebrate ttr, however, piscine ttr has a longer n-terminus which is thought to influence th-binding affinity and may influence ttr stability. we produced recombinant wild type sea bream ttr (sbttrwt) plus two mutants in which 6 (sbttrm6) and 12 (sbttrm12) n-terminal residues were removed. ligand-binding studies revealed similar af ... | 2008 | 18620020 |
| the association of host and phage dna with the membrane of escherichia coli. | the attachment of dna to membrane in t4-infected cells was investigated by means of the mg2+-sarkosyl crystals technique. both parental and progeny phage dna are associated with cell membrane throughout the eclipse period and are subsequently detached during the synthesis of mature phage. the initial attachment process does not require protein synthesis. detachment appears to be due to a "late function" since it does not occur following infection with a do mutant (amn82) or after treatment with ... | 1970 | 18620699 |
| the immense journey of bacteriophage t4--from d'hérelle to delbrück and then to darwin and beyond. | in spite of their importance, the genomics, diversity and evolution of phages and their impact on the biosphere have remained largely unexplored research domains in microbiology. here, we report on some recent studies with the t4 phage superfamily that shed some new light on these topics. | 2008 | 18621124 |
| structure of herpes simplex virus dna: topography of the molecule. i. absence of circularly permuted sequences. | only linear structures were produced by re-annealing denatured herpes simplex type 1 virus (hsv)-dna molecules, while t4-dna molecules (known to be circularly permuted and therefore used as controls in the parallel tests) formed circles. these results suggested that hsv-dna is a nonpermuted collection of sequences. unfortunately, most of the linear structures observed after re-annealing were not full-length duplexes, thus making this test not quite satisfactory. therefore another permutation tes ... | 1975 | 18621351 |
| a gene of bacteriophage t4 controlling the modification of host valyl-trna synthetase. | two hydroxylamine-induced mutants of bacteriophage t4 defective in modification of host valyl-trna synthetase have been isolated by assay of crude extracts for the activity that is characteristic of the wild-type virus. the mutations define a single gene that is situated between the ri and e genes on the t4 genetic map. this new gene is designated vs for valyl-trna synthetase. one of the mutations may be of the missense type since it results in the production of a valyl-trna synthetase activity ... | 1975 | 18621354 |
| finding blunders in thyroid testing: experience in newborns. | we evaluated thyroxin (t4) and thyroid-stimulating hormone (tsh) data along with clinical information from 600,000 newborns. we looked for certain combinations of tests and clinical data that were questionable and possibly mistaken. our approach suggests that certain combinations of test results, especially the presence of missing results deserved further evaluation for possible blunders. we found that missing tests were frequently the result of oversight. the laboratory used the well-known stan ... | 2008 | 18623119 |
| genetically engineered charge modifications to enhance protein separation in aqueous two-phase systems: charge directed partitioning. | this report continues or examination of the effect of genetically engineered charge modifications on the partitioning behavior of proteins in aqueous two-phase extration. the genetic modifications consisted of the fusion of charged peptide tails to beta-galactosidase and charge-change point mutations to t4 lysozyme. our previous article examined the influence of these charge modifications on partitioning as a function of interfacial potential difference. in this study, we examined charge directe ... | 1995 | 18623263 |
| microbiological and clinical periodontal effects of fixed orthodontic appliances in pediatric patients. | the aim of this study was to evaluate changes of microbiota in ten patients undergoing orthodontic treatment. for each patient clinical examination of gingival index (gi) and plaque index (pi) were performed at the first molars at: baseline (t1), 2 (t2), 4 (t3) and 12 weeks (t4). at the same time subgingival plaque and tongue samples were taken for the microbiological study. clinical results showed that at t4, the mean pi score was significantly lower than t1 and the gi was markedly reduced. mic ... | 2008 | 18623999 |
| congenital nephrotic syndrome, an uncommon presentation of cytomegalovirus infection. | cytomegalovirus (cmv) infection is a very rare infection in children as well as in infancy. in cmv infection extra renal manifestations in central nervous system (cns), eyes and hematological are prominent and common than renal manifestation. we are describing two case reports one at the age of 5 months and another at one month with features of both extra renal and renal manifestations of nephritic syndrome. our first case presented with predominant features of cns manifestations like convulsion ... | 2008 | 18626461 |
| laparoscopic resection for endoscopically unresectable colorectal polyps: analysis of 525 patients. | for the management of endoscopically irretrievable polyps, several minimally invasive procedures are currently available as alternatives to conventional laparotomy. however, the high rate of malignant transformation despite initially benign histology continues to be a problem. | 2008 | 18626704 |
| the headful packaging nuclease of bacteriophage t4. | most tailed bacteriophages and herpes viruses replicate genome as a concatemer which is cut by a 'headful' nuclease upon completion of genome packaging. here, the catalytic centre of phage t4 headful nuclease, present in the c-terminal domain of 'large terminase' gp17, has been defined by mutational, biochemical and structural analyses. the crystal structure shows that this nuclease has an rnase-h fold, suggesting that it cuts dna by a two-metal ion mechanism. the active centre has a mg ion co-o ... | 2008 | 18627466 |
| increased serum chitotriosidase activity following restoration of euthyroidism in patients with subclinical hypothyroidism. | whether to treat subclinical hypothyroidism (sh) remains controversial. serum chitotriosidase activity, a marker of activated macrophages, predicts new cardiovascular events. chitotriosidase activity (cht) is a new cardiovascular risk marker and is independent of c-reactive protein. the purpose of this study was to determine cht levels in sh and to examine the effect of levothyroxine replacement on cht. | 2008 | 18628578 |
| stability of soft tissue profile after mandibular setback in sagittal split osteotomies: a longitudinal and long-term follow-up study. | the aim of the study was to conduct a long-term prospective follow-up on the stability of soft tissues after bilateral sagittal split osteotomy (bsso) with rigid internal fixation to set back the mandible. | 2008 | 18634948 |
| finnish multicenter study comparing intermittent to continuous androgen deprivation for advanced prostate cancer: interim analysis of prognostic markers affecting initial response to androgen deprivation. | intermittent androgen deprivation has been proposed to prolong hormone sensitivity and improve quality of life in patients with advanced prostate cancer. the finnprostate study vii has been performed to identify patients who might benefit from intermittent androgen deprivation. in this interim analysis we evaluated which prognostic markers affect the initial response to androgen deprivation therapy. | 2008 | 18635219 |
| outcomes for schizophrenia patients with clozapine treatment: how good does it get? | the objective of this study was to describe the extent/change (2000-2004) of clozapine prescribing in schizophrenia in new zealand and examine the outcomes associated with increasing treatment duration, and vs. those who discontinue clozapine. consecutive chart reviews were conducted for adult outpatients in auckland/northland regions (t1 = 31 march 2000, t2 = 31 october 2001, t3 = 31 march 2003, t4 = 31 october 2004). data collected included: patient characteristics, social/functional indicator ... | 2009 | 18635713 |
| [results of treatment in patients with paranasal sinus carcinoma. analysis of prognostic factors]. | analysis was based on the results of successful and unsuccessful treatment of 137 patients with paranasal sinus cancer at the oncology centre in warsaw between 1987-2002. patients with clinical stages t3 and t4 constituted 87% of cases (110 patients). radical treatment was performed on 84 patients. five-year overall survival in 137 cases amounted to 27%; and survival without recurrence was 24%. five-year overall and recurrence-free survial among patients treated with surgery and radiotherapy wer ... | 2008 | 18637419 |
| the feasibility of spinal anesthesia with sedation for laparoscopic general abdominal procedures in moderate risk patients. | one of the major advantages of laparoscopic surgery is minimizing postoperative morbidity. the previous limitations to the use of spinal anesthesia in laparoscopic surgery were the limited work space, high failure rate, more intra-operative morbidity and significant arterial blood gas alterations. however, the addition of a small-dose ketamine infusion to propofol might provide a suitable sedative combination to be used with high spinal anesthesia, producing titerable sedation, increased hemodyn ... | 2008 | 18637603 |
| anesthetic management of a patient with myotonic dystrophy for laparoscopic cholecystectomy--a case report. | myotonic dystrophy (md) is rare disease that offers challenges to anesthesiologists. we report a case of adult patient with myotonic dystrophy who underwent laparoscopic cholecystectomy. a 48-year-old male patient, known case of md, was presented for laparoscopic cholecystectomy. physical examination revealed, young man, calm, quite, cooperative, not in pain or distress with frontal baldness, temporal bone recession, elongated face, mild degree of ptosis and swan neck. under complete aseptic con ... | 2008 | 18637613 |
| the impact of pre- or postoperative radiochemotherapy on complication following anterior resection with en bloc excision of female genitalia for t4 rectal cancer. | the aim of the study was to assess the mortality and morbidity following extended anterior resection with excision of internal female genitalia combined with pre- or postoperative chemoradiotherapy in women with extensive rectal cancer. | 2009 | 18637920 |
| trends in the operative management and outcomes of t4 lung cancer. | this study describes temporal trends and variables in the operative management and outcomes of patients with t4 lung tumors in the general community. | 2008 | 18640298 |
| thoracic vertebral osteomyelitis secondary to chronic esophageal perforation. | osteomyelitis secondary to perforation of the esophagus is a rare condition. thoracic osteomyelitis after chronic esophageal perforation has never been described in the literature. | 2009 | 18640877 |
| relationship between pulmonary emphysema and osteoporosis assessed by ct in patients with copd. | osteoporosis is one of the important systemic features of copd. although copd itself is regarded as one risk factor for osteoporosis, the relationship between the extent of emphysema and reduced bone density is still unclear. our first aim was therefore to measure vertebral bone density and the percentage of low-attenuation area (laa%) in the lungs using chest ct scans in copd patients. our second aim was to investigate the relationships among ct scan measurements, anthropometric parameters, and ... | 2008 | 18641115 |
| lower life satisfaction in physicians compared with a general population sample : a 10-year longitudinal, nationwide study of course and predictors. | there is a strong need for longitudinal and representative studies that focus on doctors' well-being. | 2009 | 18642123 |
| [quality of life among patients with advanced prostate cancer: a survey using functional assessment of cancer therapy-prostate in china]. | to assess the quality of life of patients with advanced prostate cancer in china and compare the influences of different stage and different forms of therapy. | 2008 | 18642765 |
| combining infrared and low-temperature asymptotes in yang-mills theories. | we demonstrate that the powerlike nonperturbative behavior of gluon and ghost propagators in the infrared limit of yang-mills theories can provide at finite temperatures t a negative t4 contribution to the pressure and energy density. the existence of a mass gap then implies new relations between the infrared critical exponents of gluon and ghost propagators. | 2008 | 18643416 |
| subdomain competition, cooperativity, and topological frustration in the folding of chey. | the folding of multidomain proteins often proceeds in a hierarchical fashion with individual domains folding independent of one another. a large single-domain protein, however, can consist of multiple modules whose folding may be autonomous or interdependent in ways that are unclear. we used coarse-grained simulations to explore the folding landscape of the two-subdomain bacterial response regulator chey. thermodynamic and kinetic characterization shows the landscape to be highly analogous to th ... | 2008 | 18644380 |
| site-specific cleavage and religation of viral rnas. i. infectivity of barley stripe mosaic virus rna religated from functionally active segments and restoration of the internal poly(a) tract in progeny. | the genomic rnas of barley stripe mosaic virus (bsmv) were used in experiments involving site-specific cleavage to yield noninfective but functionally active fragments and subsequent restoration of infectious viral rna by means of religation. the specific fragments were obtained after site-specific cleavage of bsmv rnas with rnase h in the presence of oligo(dt)10 complementary to the internal poly(a) track in bsmv genomic rnas: (i) long (l) 5'-terminal fragments, lacking the tyrosine-accepting a ... | 1987 | 18644570 |
| the use of the papworth cocktail is detrimental to steatotic livers after ischemia-reperfusion injury. | hormonal resuscitation, specifically administration of levothyroxine (t4) and methylprednisolone (steroid, i.e., the "t4 protocol") in organ transplant donors, is becoming increasingly used. previous studies have shown that this maximizes the number of usable organs by reducing metabolic disturbances post-brain death. however, anecdotal evidence has shown that steatotic livers are adversely affected by this protocol. therefore, we sought to investigate the hypothesis that the use of t4 and stero ... | 2008 | 18645492 |
| selection of best candidates for multiorgan resection among patients with t4 gastric carcinoma. | indications for gastrectomy in t4 gastric carcinoma (gc) remain controversial. our aim was to define prognostic factors to select those patients with best chance to benefit from multiorgan resection. | 2008 | 18646043 |
| adjuvant therapy for completely resected stage ii colon cancer. | colon cancer is potentially curable by surgery. although adjuvant chemotherapy benefits patients with stage iii disease, there is uncertainty of such benefit in stage ii colon cancer. a systematic review of the literature was performed to better define the potential benefits of adjuvant therapy for patients with stage ii colon cancer. | 2008 | 18646127 |
| free t4 is negatively correlated with body mass index in euthyroid women. | overt thyroid dysfunction is well known to affect weight. however, the influence of normal-range changes in thyroid status on body mass index (bmi) is unclear. we sought to evaluate thyroid function (free t4, tsh) and its possible relationship with bmi and lipid profiles in euthyroid subjects. | 2008 | 18646506 |
| biosensor discovery of thyroxine transport disrupting chemicals. | ubiquitous chemicals may interfere with the thyroid system that is essential in the development and physiology of vertebrates. we applied a surface plasmon resonance (spr) biosensor-based screening method for the fast screening of chemicals with thyroxine (t4) transport disrupting activity. two inhibition assays using the main thyroid hormone transport proteins, t4 binding globulin (tbg) and transthyretin (ttr), in combination with a t4-coated biosensor chip were optimized and automated for scre ... | 2008 | 18647617 |
| thyroid-stimulating hormone and free thyroxine levels in persons with hfe c282y homozygosity, a common hemochromatosis genotype: the heirs study. | relationships of thyroid and iron measures in large cohorts are unreported. we evaluated thyroid-stimulating hormone (tsh) and free thyroxine (t4) in white participants of the primary care-based hemochromatosis and iron overload screening (heirs) study. | 2008 | 18651828 |
| [extended supraomohyoid neck nodes dissection in early nodal stages of oral cavity and oropharynx squamous cell cancer]. | extended supraomohyoid neck nodes dissection (esohnd) involves surgical resection of nodal levels from i to iv. the incidence of occult metastases in level v is rare and mainly depends of the location and size of the primary tumour in oral cavity and oropharynx squamous cell cancer. | 2008 | 18652157 |
| mechanism and dynamics of translesion dna synthesis catalyzed by the escherichia coli klenow fragment. | translesion dna synthesis represents the ability of a dna polymerase to incorporate and extend beyond damaged dna. in this report, the mechanism and dynamics by which the escherichia coli klenow fragment performs translesion dna synthesis during the misreplication of an abasic site were investigated using a series of natural and non-natural nucleotides. like most other high-fidelity dna polymerases, the klenow fragment follows the "a-rule" of translesion dna synthesis by preferentially incorpora ... | 2008 | 18652487 |
| relationship between serum erythropoietin levels and rt3, t4 concentrations in elderly patients with non-thyroidal illnesses. | thyroid function, plasma erythropoietin and tumor necrosis factor (tnf-alpha) concentrations were measured in 28 elderly patients with chronic non-thyroidal illnesses (nti) and in 8 healthy subjects as a control group. in the nti group, the existence of an impairment of thyroid function has been demonstrated in about 85% of the subjects, with a lower t(3) concentration; a low t(3) syndrome with low t(3) levels and high reverse-t(3) (rt(3)) plasma concentrations could be found in 25% of the subje ... | 1996 | 18653076 |
| onset of hypothyroidism with polymyositis-like clinical features in elderly patients. | impaired muscle function may be a predominant aspect of hypothyroidism and is virtually present in all patients with overt thyroid failure. less common is the onset of hypothyroidism with clinical features mimicking a polymyositis. we have observed 3 patients, whose age ranged 63-68 years, presenting with muscle aches, cramps, proximal weakness and stiffness. two patients had dysphagia. serum creatine kinase (ck) and electromyography (emc) were altered in two patients. muscle biopsy showed type ... | 1996 | 18653096 |
| thyroid function in healthy centenarians. | seven thyroid function parameters (total t3, tt3; total t4, tt4; free t3, ft3; free t4, ft4; tsh; anti-thyroglobulin antibodies, tgab; and anti-microsomal antibodies, tmab) were studied in a series of 20 healthy centenarians in order to evaluate their thyroid function status. our results showed that all the parameters were within normal range, with the exception of tt4 values which were reduced in 60% of centenarians examined. therefore, the authors believe that the production of thyroid hormone ... | 1997 | 18653108 |
| use of disphosphonates in the treatment of osteoporosis in thyroidectomized patients on levothyroxin replacement therapy. | bone mineral density at medio distal (md-bmd) and ultra distal (ud-bmd) sites of non dominant radius were studied, using a dexa mineralometer (turboscan-nim) on a series of 20 patients, over 60 years old, all thyroidectomized for thyroid carcinoma and treated with levothyroxin replacement therapy. t3 and t4 (ria method), tsh (irma method) and two cardiac parameters as tper (time peak ejection rate) and tpfr (time peak filling rate) by angiocardioscintigraphy were also determined. results showed ... | 1997 | 18653109 |
| the effect of fasting and refeeding on thyroid follicule structure and thyroid hormone levels in young and old rats. | in order to assess morphological and functional plasticity of the thyroid gland in aging the effects of fasting and refeeding on the thyroid morphology and thyroid hormone serum levels were compared with morphometry and ria in young and old rats. young (4 months) and old (24 months) male wistar rats were fasted for 40 h and sampled, or fasted and fed thereafter for 4 or 24 h. in control (fed) old animals the thyroid follicules were larger, the follicular epithelium was smaller and colloid resorp ... | 1998 | 18653134 |
| early free active versus dynamic extension splinting after extensor indicis proprius tendon transfer to restore thumb extension: a prospective randomized study. | transfer of the extensor indicis proprius tendon to the distal extensor pollicis longus (epl) tendon is a standard operation to restore thumb extension. however, several postoperative hand therapy regimens exist. the previously described early dynamic extension splinting protocol has become our standard, and we now compare it with an early active protocol in a prospective randomized study. | 2008 | 18656756 |
| the c-terminal domain of hu-related histone-like protein hlp from mycobacterium smegmatis mediates dna end-joining. | histone-like proteins (such as hu, h-ns, and fis) participate in nucleoid organization and in dna replication, recombination, and transcription. cold shock and anoxia upregulates a homologue of hu (hlp) in mycobacterium smegmatis, the nonpathogenic model of mycobacterium tuberculosis. we show using electrophoretic mobility shift assays that hlp, which in addition to the hu fold has a basic c-terminal tail containing multiple pakk and paak repeats, has very high affinity for dna. the affinity of ... | 2008 | 18656956 |
| igrt in rectal cancer. | to date, no great interest has been shown in the clinical implementation of recent image-guided radiation therapy (igrt) modalities in rectal cancer since only a few studies have been published on this issue. this may be explained by the fact that with current treatment modalities locoregional recurrences are already very low (around 10%). however, there is still room for improvement in treatment of high risk patients (ct3 crm+, ct4, n+). in these patients better results may be obtained improvin ... | 2008 | 18661433 |
| [the province of east prussia and "euthanasia" during national socialism: the ss-"aktion lange" and "aktion t4"]. | during world war ii, psychiatric patients hospitalized in asylums in eastern prussia became victims of two separate killing programmes: first, by the ss-special command lange, second by the centrally (in berlin) organized "euthanasia"-"aktion t4". by an analysis of the patient files of the victims, the present paper shows that the historical actors responsible for the killings were communicating with each other. it is now also possible to reconstruct the exact dynamic in time and space of the ki ... | 2008 | 18664012 |
| preoperative radiochemotherapy is successful also in patients with locally advanced rectal cancer who have intrinsically high apoptotic tumours. | not all patients with locally advanced rectal cancer (larc) respond equally to neo-adjuvant radiochemotherapy (rct). patients with highly apoptotic less advanced rectal cancers do not benefit from short-term radiotherapy. this study investigates whether this is also the case in the setting of rct for larc. | 2008 | 18664561 |
| demonstration of a novel hiv-1 restriction phenotype from a human t cell line. | although retroviruses may invade host cells, a productive infection can be established only after the virus counteracts inhibition from different types of host restriction factors. fv1, apobec3g/f, trim5alpha, zap, and cd317 inhibit the replication of different retroviruses by interfering with viral uncoating, reverse transcription, nuclear import, rna stability, and release. in humans, although apobec3g/3f and cd317 block hiv-1 replication, their antiviral activities are neutralized by viral pr ... | 2008 | 18665212 |
| concentration of heavy metals in various children's herbal tea types and their correlations. | this investigation was undertaken to determine the concentrations of cadmium, lead, mercury, zinc, copper and magnesium in six tea types used as children's tea. six types of tea of different herbal composition used for children's consumption (t1, t2, t3, t4, t5 and t6) were analyzed in three subsequent collections. the analysis of cadmium showed that the concentration was very similar in all types of children's tea, ranging from 0.233 to 0.369 mg/kg. lead concentrations were in the range of 0.34 ... | 2008 | 18665991 |
| [triiodothyroacetic acid in euthyroid goiter. new data on its mechanisms of action. comparison with l-thyroxin]. | euthyroid goiter is usually treated with ths-inhibiting doses of l-thyroxin (l-t4), which can have troublesome adverse effects. it has been suggested that triiodothyroacetic acid (triac), a tsh suppressor, might have fewer peripheral effects and better tolerability than t4. we therefore compared the risk-benefit ratios of the two drugs. thirty-six women with euthyroid goiter (no thyroid cancer) were randomized to receive either triac (19.6 ug/kg) (n=19) or l-t4 (1.7 ug/kg) (n=17) for 11 months. ... | 2007 | 18666468 |
| [the effect of long-term external ionizing radiation on the functional activity of rat thyroid under enhanced potassium iodide consumption]. | the study was devoted to the effect of long-term (20 days) external ionizing radiation at a dose of 0.5 gy on the iodide metabolism in the rat thyroid under supplementation of high iodine doses (10 daily ki doses). it was found that the potassium iodide administration partially prevented the effects of a post radiation decrease of serum thyroid hormone levels (the level of t4 was normal and that of t3 was 77.4% of the controls). after the supplementation of 10 daily iodide doses, the rat thyroid ... | 2008 | 18666583 |
| neonatal screening for congenital hypothyroidism in the federation of bosnia and herzegovina: eight years' experience. | this report demonstrates the prevalence of primary congenital hypothyroidism (ch) in the federation of bosnia and herzegovina and summarizes the laboratory data. neonatal thyroid-stimulating hormone (tsh) was measured in whole blood drawn between the 3rd and 5th days of life and spotted on filter paper using the fluorometric assay. among the 87,061 neonates, 22 had ch, 13 dysgenetic forms, and nine with thyroids in situ. no differences were found between the two types in terms of tsh and total t ... | 2009 | 18668261 |
| d2 lymphadenectomy alone or with para-aortic nodal dissection for gastric cancer. | gastrectomy with d2 lymphadenectomy is the standard treatment for curable gastric cancer in eastern asia. whether the addition of para-aortic nodal dissection (pand) to d2 lymphadenectomy for stage t2, t3, or t4 tumors improves survival is controversial. we conducted a randomized, controlled trial at 24 hospitals in japan to compare d2 lymphadenectomy alone with d2 lymphadenectomy plus pand in patients undergoing gastrectomy for curable gastric cancer. | 2008 | 18669424 |
| randomized phase iii study comparing preoperative radiotherapy with chemoradiotherapy in nonresectable rectal cancer. | preoperative chemoradiotherapy is considered standard treatment for locally advanced rectal cancer, although the scientific evidence for the chemotherapy addition is limited. this trial investigated whether chemotherapy as part of a multidisciplinary treatment approach would improve downstaging, survival, and relapse rate. | 2008 | 18669453 |
| hypothyroidism protects di(n-butyl) phthalate-induced reproductive organs damage in sprague-dawley male rats. | this study examined the deleterious effects of di(n-butyl) phthalate (dbp) on the male reproductive organs in hypothyroid rats. hypothyroidism was induced in prepubertal male rats (28 days of age) by an intraperitonial (i.p.) injection of 10 mg/kg/day propylthiouracil (ptu) for 30 days. dbp (100 and 500 mg/kg/day) was administered by oral gavages to the intact or hypothyroid rats for 30 days. the body weight of the ptu-treated rats was significantly lower than the control group. the total triiod ... | 2008 | 18670161 |
| pancreatitis caused by reovirus in guinea-fowl. | pancreatitis caused by a reovirus was observed among 8- to 22-day-old guinea-fowls held under extensive conditions in groups of 10,000 birds. with the virus isolated from the affected birds the disease entity could be reproduced experimentally. both the naturally affected and the experimentally infected birds showed depression, lack of appetite and weakness, followed by recumbency, opisthotonus and, occasionally, convulsions. a proportion of the survivors were retarded in growth and stunted. at ... | 1994 | 18671072 |
| serum levels of adenosine deaminase and pregnancy-related hormones in hyperemesis gravidarum. | we investigated the correlation between pregnancy-related hormones and serum adenosine deaminase (indicator of cellular immunity) level in women with hyperemesis gravidarum. | 2009 | 18673094 |
| portal protein diversity and phage ecology. | oceanic phages are critical components of the global ecosystem, where they play a role in microbial mortality and evolution. our understanding of phage diversity is greatly limited by the lack of useful genetic diversity measures. previous studies, focusing on myophages that infect the marine cyanobacterium synechococcus, have used the coliphage t4 portal-protein-encoding homologue, gene 20 (g20), as a diversity marker. these studies revealed 10 sequence clusters, 9 oceanic and 1 freshwater, whe ... | 2008 | 18673386 |
| role of external beam radiotherapy in patients with advanced or recurrent nonanaplastic thyroid cancer: memorial sloan-kettering cancer center experience. | external beam radiotherapy (ebrt) plays a controversial role in the management of nonanaplastic thyroid cancer. we reviewed our institution's outcomes in patients treated with ebrt for advanced or recurrent nonanaplastic thyroid cancer. | 2009 | 18676097 |
| multiple atp binding is required to stabilize the "activated" (clamp open) clamp loader of the t4 dna replication complex. | most dna replication systems include a sliding clamp that encircles the genomic dna and links the polymerase to the template to control polymerase processivity. a loading complex is required to open the clamp and place it onto the dna. in phage t4 this complex consists of a trimeric clamp of gp45 subunits and a pentameric loader assembly of four gp44 and one gp62 subunit(s), with clamp loading driven by atp binding. we measure this binding as a function of input ligand concentration and show tha ... | 2008 | 18676368 |
| outcomes of adjuvant chemoradiotherapy after a radical gastrectomy and a d2 node dissection for gastric adenocarcinoma. | intergroup 0116 (int-0116) established adjuvant chemoradiation as the standard of care for resected high-risk adenocarcinoma of the stomach in the united states. however, adjuvant chemoradiation remains controversial in many parts of asia and europe, where patients tend to undergo a more thorough d2 dissection. in int-0116, 90% of patients had a limited or inadequate node dissection (d0 or d1). also, 17% of patients in the chemoradiation arm had to discontinue treatment because of toxicities. th ... | 2008 | 18677137 |
| stability of hard tissue profile after mandibular setback in sagittal split osteotomies: a longitudinal and long-term follow-up study. | the aim of the study was to conduct a long-term follow-up on the stability of the hard tissues after bilateral sagittal split osteotomy (bsso) with rigid internal fixation (rif)to set back the mandible and to compare it with that of mandibular advancement performed by the same team of surgeons and with the same examination protocol. seventeen consecutive patients (6 females and 11 males) could be re-examined 12.7 years (t5) after surgery. the previous examinations were before surgery (t1), 5 day ... | 2008 | 18678756 |
| stapled closed technique for laryngectomy and pharyngeal repair. | total laryngectomy is a recognised treatment for advanced laryngeal carcinoma. traditionally, pharyngeal repair is performed with layered sutures. we describe our experience with a technique of closed pharyngoplasty using a linear stapler device. | 2008 | 18680636 |
| thyroid testing in sloughis. | thyroid hormone concentrations were found to be different in greyhounds and whippets compared with nonsight hound dogs. | 2008 | 18681922 |
| [usefulness of bilateral sympathectomy using video-assisted thorascopic surgery in the treatment of essential hyperhidrosis]. | essential, idiopathic, or primary hyperhidrosis is defined as excessive sweating in certain areas of the body due to factors unrelated to other disease. clinical presentation can be categorized as palmar, plantar, axillary, or craniofacial. medical treatment (aluminium salts, iontophoresis, anticholinergic drugs, and alpha2-agonists) is of questionable effectiveness. intradermal injections of botulinum toxin are very effective for the treatment of axillary hyperhidrosis. surgical treatment invol ... | 2008 | 18682164 |
| deiodinase-mediated thyroid hormone inactivation minimizes thyroid hormone signaling in the early development of fetal skeleton. | thyroid hormone (th) plays a key role on post-natal bone development and metabolism, while its relevance during fetal bone development is uncertain. to study this, pregnant mice were made hypothyroid and fetuses harvested at embryonic days (e) 12.5, 14.5, 16.5 and 18.5. despite a marked reduction in fetal tissue concentration of both t4 and t3, bone development, as assessed at the distal epiphyseal growth plate of the femur and vertebra, was largely preserved up to e16.5. only at e18.5, the hypo ... | 2008 | 18682303 |
| reversal of cadmium-induced thyroid dysfunction by selenium, zinc, or their combination in rat. | the aim of this study was to evaluate the potential benefit of combined treatment with zinc (zn) and selenium (se) in reversing cadmium (cd)-induced thyroid dysfunction compared to se or zn treatment alone in rats exposed to cd. for this purpose, 30 adult male wistar albino rats were equally divided into control and four treated groups receiving either 200 ppm cd (as cdcl2), 200 ppm cd + 500 ppm zn (as zncl2), 200 ppm cd + 0.1 ppm se (as na2seo3), or 200 ppm cd + 500 ppm zn + 0.1 ppm se in their ... | 2008 | 18685812 |
| on the importance of selenium and iodine metabolism for thyroid hormone biosynthesis and human health. | the trace elements iodine and selenium (se) are essential for thyroid gland functioning and thyroid hormone biosynthesis and metabolism. while iodine is needed as the eponymous constituent of the two major thyroid hormones triiodo-l-thyronine (t3), and tetraiodo-l-thyronine (t4), se is essential for the biosynthesis and function of a small number of selenocysteine (sec)-containing selenoproteins implicated in thyroid hormone metabolism and gland function. the se-dependent iodothyronine deiodinas ... | 2008 | 18686295 |
| event related oscillations in euthymic patients with bipolar disorder. | bipolar disorder involves dysfunction in gamma amino butyric acid (gaba)/glutamatergic systems and neural circuits that regulate cognitive processing. valproate, a mood stabilizing anticonvulsant, modulates gaba/glutamate and shows neuroprotective effect. electroencephalographic oscillatory activity assessment is an alternative brain imaging technique with high time resolution. it presents integrative brain functioning. we aimed to assess the oscillatory responses of patients with bipolar disord ... | 2008 | 18687385 |
| double-strand dna cleavage by copper complexes of 2,2'-dipyridyl with guanidinium/ammonium pendants. | two ligands with guanidinium/ammonium groups were synthesized and their copper complexes, [cu(l1)cl2](clo4)2.h2o (1) and [cu(l2)cl2](clo4)2 (2) (l1 = 5,5'-di[1-(guanidyl)methyl]-2,2'-bipyridyl cation and l2 = 5,5'-di[1-(amino)methyl]-2,2'-bipyridyl cation), were prepared to serve as nuclease mimics. x-ray analysis revealed that cu(ii) ion in 1 has a planar square cun2cl2-configuration. the shortest distance between the nitrogen of guanidinium and copper atoms is 6.5408(5) a, which is coincident ... | 2008 | 18688419 |
| overexpression of a secretory leukocyte protease inhibitor in human gastric cancer. | complementary dna microarrays have identified aberrantly expressed genes in patients with gastric cancer. one that encodes secretory leukocyte protease inhibitor (slpi) is among the aberrantly expressed genes and is associated with metastasis in gastric cancers. we evaluated the potential of slpi expression as a helpful biomarker for detection of gastric cancer. tumor tissue and matching noncancerous mucosa were obtained from 60 patients immediately after gastric resection. slpi expression level ... | 2008 | 18688858 |
| primary hypothyroidism in a child simulating a prolactin-secreting adenoma. | to report a case of primary hypothyroidism associated to hyperprolactinemia mimicking a prolactin secreting adenoma. | 2008 | 18690463 |
| [continuous subarachnoid analgesia and anesthesia for labor and cesarean section in a patient who had previously undergone surgery for ependymoma]. | we report the case of a 38-year-old primipara who had undergone surgery 2 years earlier for an intradural ependymoma at l2-l3 and who was currently asymptomatic. a combined epidural-subarachnoid block was performed for analgesia during labor but this technique was only effective for the first 2 hours. when analgesia via epidural cannula was no longer adequate, it was decided to perform a continuous subarachnoid block. later, the fetus's head was seen to be too large to fit through the pelvis; fo ... | 2008 | 18693664 |
| refractory headaches due to multilevel thoracic cerebrospinal fluid leaks. | spontaneous cerebrospinal fluid leak is a well-documented cause of postural headache. we report a medically refractory headache due to multilevel thoracic cerebrospinal fluid leaks. | 2008 | 18694451 |
| lc3, an autophagosome marker, is highly expressed in gastrointestinal cancers. | autophagy is a bulk protein and organelle degradation process essential for cell maintenance and viability. microtubule-associated protein 1 light chain 3 (lc3), the mammalian homologue of yeast atg8, is involved in autophagosome formation during autophagy. the aim of this study was to investigate lc3 expression in gastrointestinal cancers to elucidate the role of autophagy in human cancer development. we evaluated lc3 expression by immunohistochemistry in 163 gastrointestinal cancers including ... | 2008 | 18695874 |
| lactotransferrin: a candidate tumor suppressor-deficient expression in human nasopharyngeal carcinoma and inhibition of npc cell proliferation by modulating the mitogen-activated protein kinase pathway. | lactotransferrin (ltf) has been shown to regulate tumorogenesis. however, little is known about the role of ltf in regulating the development of human nasopharyngeal carcinoma (npc). the aim of our study was to investigate whether ltf could regulate the development of npc by characterizing the pattern of ltf expression in human npc tissues using cdna and tissue microarrays. loss of ltf expression was observed in a significantly higher frequency of npc tissues compared to that in nontumor nasopha ... | 2008 | 18697201 |
| [streptococcus pneumoniae growth based on drug resistance genotype]. | marked streptococcus pneumoniae tolerance is attributed to a penicillin and macrolide resistance genotypes, yet no report has, to our knowledge, compared the ability of these two genotypes to grow. deviations in the number of clinical appearances of streptococcus pneumoniae depend on the combination of these genotypes, thought primarily due to the individual strain growth. to test this, we compared atcc6303 and a strain of each genotype with an absorption spectrophotometer. time points-t0, t2, t ... | 2008 | 18697479 |
| relationship between anti-thyroid peroxidase antibody and thyroid function test. | anti-thyroid peroxidase antibody (anti-tpo antibody) is a member of thyroid autoantibodies which are important in inducing and also diagnosing autoimmune thyroid diseases. thyroid autoimmunity can cause several forms of thyroiditis and abnormal thyroid functions, ranging from hypothyroidism to hyperthyroidism. | 2006 | 18698125 |
| prognostic relevance of centromere protein h expression in esophageal carcinoma. | many kinetochore proteins have been shown to be associated with human cancers. the aim of the present study was to clarify the expression of centromere protein h (cenp-h), one of the fundamental components of the human active kinetochore, in esophageal carcinoma and its correlation with clinicopathological features. | 2008 | 18700042 |
| [a case of advanced gastric cancer successfully treated with s-1 and paclitaxel followed by curative resection]. | a 59-year-old man diagnosed with stage iv advanced gastric cancer due to pancreatic invasion(t4)and splenic hilum lymph node metastasis(n3)was initially treated with neoadjuvant chemotherapy using s-1 and cddp. however, it was discontinued because the tumor marker increased after 1 course. instead of s-1 and cddp, s-1 and paclitaxel were then administered. after 4 courses, ct scan revealed reduced tumor size and the disappearance of splenic hilum lymph node swelling that indicated pr of the chem ... | 2008 | 18701853 |
| redor nmr characterization of dna packaging in bacteriophage t4. | bacteriophage t4 is a large-tailed escherichia coli virus whose capsid is 120x86 nm. atp-driven dna packaging of the t4 capsid results in the loading of a 171-kb genome in less than 5 min during viral infection. we have isolated 50-mg quantities of uniform (15)n- and [epsilon-(15)n]lysine-labeled bacteriophage t4. we have also introduced (15)nh(4)(+) into filled, unlabeled capsids from synthetic medium by exchange. we have examined lyo- and cryoprotected lyophilized t4 using (15)n{(31)p} and (31 ... | 2008 | 18703073 |
| nmo-igg positive neuromyelitis optica in a patient with myasthenia gravis but no thymectomy. | here we report on a 44-year old woman presenting with both myasthenia gravis (mg) and neuromyelitis optica (nmo). mri showed transverse myelitis extending from c2 to t4, multifocal demyelinating lesions in the supratentorial white matter, and left optic neuritis. serological analysis demonstrated antibodies to acetylcholine receptors as well as nmo-igg. to our knowledge, this is the first case of nmo-igg positive nmo in a patient with mg but no history of thymectomy or immunosuppression. | 2008 | 18703206 |
| [pure colloid carcinoma of the breast: anatomoclinical study of seven cases]. | breast mucinous carcinoma is a particular histological form characterized by the extracellular production of mucus. the pure form is rarely reported and its prognostic is better than the other types of the breast cancer. the aim of the present study was to discuss the various anatomoclinical, therapeutic aspects and the prognostic factors of the pure mucinous carcinoma of the breast. | 2009 | 18703371 |
| cancer of the external auditory canal and middle ear in denmark from 1992 to 2001. | in the context of the danish head and neck cancer group, nationwide material from 1992-2001 was analyzed to study the extent and nature of the disease, evaluate treatment, compare staging systems, and examine prognosis and survival. | 2008 | 18704969 |
| diagnostic and prognostic value of peritoneal cytology in biliary tract cancer. | evaluation of peritoneal cytology provides valuable prognostic information in abdominal cancers. the aim of this study is to assess the incidence and the prognostic value of conventional peritoneal cytology in biliary tract cancers. | 2008 | 18705279 |
| assessment of surgical treatment in elderly patients with breast cancer. | the incidence of breast cancer increases with advancing age and in clinical practice approximately 50% of new cases occur in women over the age of 65 years. although breast cancer in elderly patients presents more favorable biological characteristics than similar-stage cancer in younger women, disease control still remains uncertain and is becoming a major health problem. | 2008 | 18705397 |
| assessment of right ventricular function by pressure-volume loops in off-pump coronary artery bypass surgery. | right ventricular function plays an important role in the hemodynamic derangement during off-pump coronary artery bypass (opcab) surgery. pressure-volume loops have been shown to provide load-independent information of cardiac function. therefore, the aim of this study was to investigate the feasibility of construction of right ventricular pressure-volume loops with pressure and volume data measured by a volumetric pulmonary artery catheter (pac) and to evaluate right ventricular systolic and di ... | 2008 | 18706209 |
| does the direction of pedicle screw rotation affect the biomechanics of direct transverse plane vertebral derotation? | in vitro biomechanical investigation using human cadaveric vertebrae. | 2008 | 18708929 |
| characteristics of visual seeking and evoked potentials in the extrastriate areas of the cortex in humans. | studies in 11 young, healthy subjects addressed the characteristics of visual seeking (time taken, errors) on changes in the parameters of the target element to be sought (shape, color, and location) in an environment containing heterogeneous white distractors. evoked potentials (ep) were recorded in six cortical leads (p3, p4, t3, t4, t5, t6) and the late endogenous components of ep were studied, i.e., the n2 and p3 components (standard terminology), as these components are known to change when ... | 2008 | 18709466 |
| prevalence and functional analysis of the s107p polymorphism (rs6647476) of the monocarboxylate transporter 8 (slc16a2) gene in the male population of north-west spain (galicia). | mutations in slc16a2, the gene encoding the thyroid hormone (th)-specific transporter monocarboxylate transporter 8 (mct8), result in a thyroid phenotype and severe mental retardation caused by neuronal th deficiency. these mutational effects raise the question of whether polymorphic variation in slc16a2 may also be associated with differences in serum levels of th and/or tsh. | 2009 | 18710470 |
| patterns of recurrence following liver resection for colorectal metastases: effect of primary rectal tumor site. | patients with rectal adenocarcinoma are at increased risk of locoregional recurrence compared with patients with colon cancer. this may affect the pattern of recurrence and survival rates following hepatic resection of liver metastases from rectal adenocarcinoma. | 2008 | 18711033 |
| prognostic values of serum cystatin c and beta2 microglobulin, urinary beta2 microglobulin and n-acetyl-beta-d-glucosaminidase in early acute renal failure after liver transplantation. | acute renal failure (arf) after liver transplantation is associated with high mortality and morbidity. early therapeutic or preventive intervention is hampered by the lack of early effective prognostic factors. recent studies indicated that serum levels of cystatin c and beta2-microglobulin (beta2 mg) as well as urinary beta2 mg and n-acetyl-beta-d-glucosaminidase (nag) would increase in patients with early and mild renal impairment. in this study, these factors were detected during the differen ... | 2008 | 18713542 |
| [determining the thyroid hormones t3 and t4 in the urine: an unreliable test for hypothyroidism]. | | 2008 | 18714524 |
| the effect of timing of application of positive end-expiratory pressure on oxygenation during one-lung ventilation. | many studies have confirmed that applying positive end-expiratory pressure (peep) to the dependent lung during one-lung ventilation (olv) improves oxygenation. our purpose was to investigate the best time and level of peep application. thirty patients undergoing thoracic surgery were randomised into three groups. after 20 minutes of two-lung ventilation (tlv) in the lateral position, all patients received olv for one hour during olv, 0, 5, 10 cmh2o peep were applied in order in group a, with eac ... | 2008 | 18714623 |
| [renal function in white rats after tiroxin injection preceded by blockade of ace and nitrogen oxide]. | purpose of this work was to study renal function in white rats following a single dose of exogenous tiroxin (t4) on a background of non-selective no-synthase blocker or inhibition of angiotensin-1 converting enzyme. the experiment was performed with males of outbred white rats (body mass = 140-180 g). three days prior to t4 injection, the animals drank water solution of captopril (20 mg/l) or were injected intra-gastrically with water solution of non-selective no-synthase blocker n(omega)-nla (1 ... | 2008 | 18714730 |
| folding transition of a single semiflexible polyelectrolyte chain through toroidal bundling of loop structures. | we consider how the dna coil-globule transition progresses via the formation of a toroidal ring structure. we formulate a theoretical model of this transition as a phenomenon in which an unstable single loop generated as a result of thermal fluctuation is stabilized through association with other loops along a polyelectrolyte chain. an essential property of the chain under consideration is that it follows a wormlike chain model. a toroidal bundle of loop structures is characterized by a radius a ... | 2008 | 18715107 |