| incidence of iodine deficiency in turkish patients with congenital hypothyroidism. | turkey is located in an area of mild to moderate iodine deficiency. the aim of the present study was to investigate the incidence of iodine deficiency in patients with congenital hypothyroidism. | 2008 | 18533935 |
| foldon-guided self-assembly of ultra-stable protein fibers. | a common objective in protein engineering is the enhancement of the thermodynamic properties of recombinant proteins for possible applications in nanobiotechnology. the performance of proteins can be improved by the rational design of chimeras that contain structural elements with the desired properties, thus resulting in a more effective exploitation of protein folds designed by nature. in this paper, we report the design and characterization of an ultra-stable self-refolding protein fiber, whi ... | 2008 | 18535304 |
| [influence of humic acid fertilizer on biomass accumulation and quality of angelica sinensis]. | to study the influence of humic acid fertilizer on plant growth, assimilation base, dried biomass accumulation, yield, quality and disease infection of angelica sinensis. | 2008 | 18536458 |
| hyperplastic goitre and mortality in captive-reared black stilts ( himantopus novaezelandiae ). | to study the gross, histopathological and clinico-pathological findings in cases of hyperplastic goitre in sub-adult captive- reared black stilts following their release on riverbeds in the south canterbury region of new zealand. | 2008 | 18536773 |
| congenital hypothyroidism. | congenital hypothyroidism (ch) is one of the most common preventable causes of mental retardation with a worldwide incidence of 1:4000 live births. ideally universal screening at 3-4 days of age should be done for detecting ch. abnormal values on screening (t4 < 6.5 ug/dl, tsh > 20 micro/l) should be confirmed by a venous sample (using age appropriate cutoffs) before initiating treatment. term as well as preterm infants with low t4 and elevated tsh should be started on l-thyroxine at a dose of 1 ... | 2008 | 18536892 |
| intraoperative radiotherapy combined with adjuvant chemoradiotherapy for locally advanced gastric adenocarcinoma. | to evaluate the efficacy of intraoperative radiotherapy (iort) followed by concurrent chemotherapy and external beam rt (ebrt) in the treatment of locally advanced gastric adenocarcinoma. | 2008 | 18538489 |
| survival effect of neoadjuvant radiotherapy before esophagectomy for patients with esophageal cancer: a surveillance, epidemiology, and end-results study. | the role of neoadjuvant radiotherapy (neort) before definitive surgery for esophageal cancer remains controversial. this study used a large population-based database to assess the effect of neort on survival for patients treated with definitive surgery. | 2009 | 18538500 |
| amino acid residues in the giy-yig endonuclease ii of phage t4 affecting sequence recognition and binding as well as catalysis. | phage t4 endonuclease ii (endoii), a giy-yig endonuclease lacking a carboxy-terminal dna-binding domain, was subjected to site-directed mutagenesis to investigate roles of individual amino acids in substrate recognition, binding, and catalysis. the structure of endoii was modeled on that of uvrc. we found catalytic roles for residues in the putative catalytic surface (g49, r57, e118, and n130) similar to those described for i-tevi and uvrc; in addition, these residues were found to be important ... | 2008 | 18539732 |
| thyroid function in 76 sick preterm infants 30-36 weeks: results from a longitudinal study. | to assess thyroid function in 76 sick preterm infants 30-36 weeks gestational age. | 2008 | 18540250 |
| persistently raised thyroid stimulating hormone in adequately treated congenital hypothyroidism on long-term follow-up. | to determine the percentage of patients with inappropriate secretion of tsh (istsh) in a large cohort of patients with congenital hypothyroidism (ch), and to examine a probable influence of the pretreatment t4 or tsh levels and the etiology of ch on istsh by describing the clinical features of these patients. | 2008 | 18540252 |
| oral health in the adult population of västerbotten, sweden--a comparison between an epidemiological survey and data obtained from digital dental records. | the objective of this study was to analyse the possibilities and limitations of using data drawn from electronic dental patient records (edprs) in monitoring dental health among adults in a northern swedish county. | 2008 | 18540517 |
| [evaluation of antiretroviral therapy in hiv-infected adults in the department of haematology, university hospital of brazzavllle, congo]. | a retrospective study was conducted during 32 months; from 1 may 2003 to 30 december 2005 in haematology department. the objective of the study was to assess the effectiveness of the anti retroviral therapy 157 patients receiving antiretroviral treatment for at least a twelve month-period and presenting aids symptoms based on revised cdc criteria were included. the average number of initial t4 lymphocytes is 133/mm3 (extremes 1 and 385) and the initial plasmatic average viral load, quantified in ... | 2008 | 18543703 |
| trait anxiety determines depressive symptoms and fatigue in women with an abnormality in the breast. | the aim was to examine the role of trait anxiety and diagnosis on depressive symptoms and fatigue in women with early stage breast cancer or benign breast problems. | 2009 | 18544184 |
| variability in thyroid-stimulating hormone suppression by human chorionic [corrected] gonadotropin during early pregnancy. | the objective of the study was to further explore relationships between human chorionic gonadotropin (hcg), tsh, and free t4 in pregnant women at 11 through 18 wk gestation. | 2008 | 18544616 |
| [effect of pinggan qianyang on hypothalamic proteome in the hyperthyroid rats with hyperactivity of liver-yang]. | to investigate the effect of pinggan-qianyang (pgqy), a chinese medicine, on hypothalamic proteome in the hyperthyroid rats with hyperactivity of liver-yang, and to explore its mechanism. | 2008 | 18544841 |
| effects of the height of ball-backrest on head and shoulder posture and trunk muscle activity in vdt workers. | this study was designed to elucidate the effects of a ball-backrest at different heights on the head and shoulder posture and neck and trunk muscles of visual display terminal (vdt) workers who adopted a forward head posture when working at a vdt. twenty-three vdt workers with forward head posture performed the keyboard typing work at a vdt without and with a ball-backrest at the l3, t10, and t4 levels. surface electromyograms were recorded from the neck, shoulder, and trunk muscles, and the for ... | 2008 | 18544890 |
| radiotherapy as primary treatment modality. | the proper management of prostate cancer is dependent on appropriate risk categorization, based on pretreatment prostate-specific antigen (psa), clinical stage and gleason score (gs). the use of radiotherapy in low-risk (t1-t2a, psa < 10 ng/ml and gs <or= 6) and intermediate-risk (t1/t2, psa < 20 ng/ml and gs <or= 7) disease is well established, with comparable results to surgery in the era of modern radiation therapy. however, cancer-related outcomes in some radiotherapy patients might still be ... | 2008 | 18544981 |
| [alterations of cell cycle regulating proteins: rb, p21 and p16 in laryngeal cancer]. | in cell cycle, most of the regulatory actions occur at the so-called restriction point (r) in the late g1 phase. tumor suppressor genes; rb, p53 and p21 are among the most important of the agents suppressing transition through r point. changes in the expression of rb (retinoblastoma) gene correlate with the presence of rb protein and they are believed to be an early event in carcinogenesis. this issue seems to be not plainly defined in laryngeal cancer. p21 with p16, cyclin d1 and rb genes that ... | 2007 | 18546941 |
| thyroid storm in a polytrauma patient. | we report the case of a 38 year-old woman who presented initially as the driver in a road traffic accident with a glasgow coma score of 14, agitated, tachycardic, tachypnoeic and hypertensive. the combination of an abdominal ct scan and clinical findings led to the decision to perform an emergency laparotomy. her persisting symptoms and laboratory results revealed her to be manifesting acute thyroid storm; tsh of < 0.10 iu.l(-1), free t4 of 59.8 pmol.l(-1) and free t3 of 20.20 pmol.l(-1). | 2008 | 18547297 |
| maximum acute exercise tolerance in hyperthyroid and hypothyroid rats subjected to forced swimming. | thyroid dysfunction can compromise physical capacity. here, we analyze the effects of hyperthyroidism and hypothyroidism on maximum swim time in rats subjected to acute forced swimming, as an indicator of anaerobic capacity. animals were forced to swim against a load (5% of body weight) attached to the tail and were killed 48 hours after the last test. hyperthyroid rats were treated with thyroxine (50 mug/100 g body weight, i. p. for 7 days). the hypothyroid group received 0.03% methimazole in t ... | 2008 | 18548387 |
| t4 sympathectomy for palmar hyperhidrosis: looking for the right operation. | most surgeons still perform t2 or t2-3 sympathectomy for palmar hyperhidrosis (ph), but both of these treatments can cause severe side effects. some recent articles advocating t4 sympathectomy have obtained satisfactory results. the aim of this study was to compare the outcomes of 3 different levels of sympathectomy. between july 2003 and july 2006, we treated 60 patients (20 men and 40 women, mean age 26 years) who suffer from palmar hyperhidrosis by endoscopic thoracic sympathectomy (ets). pat ... | 2008 | 18549895 |
| atypical clinical presentation of idiophatic thoracic spinal cord herniation. | case report. | 2008 | 18552662 |
| thoracic myelopathy due to idiopathic epidural ossifications in a child: a case report. | a rare case of thoracic myelopathy due to epidural ossification in a child. | 2008 | 18552663 |
| restoration of thoracic kyphosis by posterior instrumentation in adolescent idiopathic scoliosis: comparative radiographic analysis of two methods of reduction. | a retrospective comparison of radiographic results for 2 consecutive series of patients treated for adolescent idiopathic scoliosis (ais) by posterior instrumentations with thoracic screws using 2 methods of reduction: sequential approximation by cantilever reduction (cr) and simultaneous translation technique on 2 rods (st2r). | 2008 | 18552674 |
| effects of electrostatic screening on the conformation of single dna molecules confined in a nanochannel. | single t4-dna molecules were confined in rectangular-shaped channels with a depth of 300 nm and a width in the range of 150-300 nm casted in a poly(dimethylsiloxane) nanofluidic chip. the extensions of the dna molecules were measured with fluorescence microscopy as a function of the ionic strength and composition of the buffer as well as the dna intercalation level by the yoyo-1 dye. the data were interpreted with the scaling theory for a wormlike polymer in good solvent, including the effects o ... | 2008 | 18554066 |
| normal serum bone markers in bisphosphonate-induced osteonecrosis of the jaws. | we obtained serum bone markers and other relevant endocrine assays on 5 patients with osteonecrosis of the jaw (onj). the assays were c-telopeptide, n-telopeptide, bone-specific alkaline phosphatase, osteocalcin, intact parathyroid hormone, t3, t4, tsh, and vitamin d 25 hydroxy. diagnostic criteria for onj were those formulated by the american association of oral and maxillofacial surgeons. four of our patients were women. two had metastatic breast cancer and had been treated with zoledronic aci ... | 2008 | 18554944 |
| surgical approaches and techniques in the management of severe hyperhidrosis. | thoracoscopy has afforded a huge advance for upper thoracic sympathetic procedures compared with prior open procedures. different clinical syndromes of hyperhidrosis exist and require different forms of treatment. the classic severe palmoplantar pattern of hyperhidrosis will not respond effectively in the long term to any nonoperative treatment and requires sympathectomy for cure. thoracoscopic sympathectomy is the first-line treatment in these patients. the author's preference is sympathotomy a ... | 2008 | 18557590 |
| endoscopic thoracic sympathectomy: at what level should you perform surgery? | several interventions are possible on the sympathetic chain and the nomenclature has been confusing. the authors propose a uniform nomenclature for each procedure, mainly, sympathectomy for resection or ablation of the ganglion, sympathicotomy for the transaction of the chain, ramicotomy for the procedure preserving the chain and ganglia and severing the rami, and finally, sympathetic block for clipping above and below the ganglia. they recommend intervention on the t2 ganglia for facial hyperhi ... | 2008 | 18557591 |
| neostigmine but not sugammadex impairs upper airway dilator muscle activity and breathing. | cholinesterase inhibitor-based reversal agents, given in the absence of neuromuscular block, evoke a partial upper airway obstruction by decreasing skeletal upper airway muscle function. sugammadex reverses neuromuscular block by encapsulating rocuronium. however, its effects on upper airway integrity and breathing are unknown. | 2008 | 18559352 |
| thyroid autoantibodies in women with and without thyroid disorders in an iodine-replete area. | to compare the prevalence of positive autoantibodies in patients with thyroid disorders and healthy subjects in an iodine-replete area of the islamic republic of iran, we studied 930 women in a clinic-based study: 698 patients (286 hypothyroid, 140 hyperthyroid, 272 with simple goitre) and 232 healthy women. serum thyroxine (t4), triiodothyronine (t3), thyroid stimulating hormone, and anti-thyroid antibodies were measured. positive autoantibodies were detected in 75.5% of patients with hypothyro ... | 2008 | 18561724 |
| population similarity analysis of indicator bacteria for source prediction of faecal pollution in a coastal lake. | biochemical fingerprinting (bf) databases of 524 enterococci and 571 escherichia coli isolates and an antibiotic resistance analysis (ara) database comprising of 380 e. coli isolates from four suspected sources (i.e. dogs, chickens, waterfowls, and human sewage) were developed to predict the sources of faecal pollution in a recreational coastal lake. twenty water samples representing four sampling episodes were collected from five sites and the enterococci and e. coli population from each site w ... | 2008 | 18561957 |
| the associative nature of adenylyl transfer catalyzed by t4 dna ligase. | dna ligase seals nicks in dsdna using chemical energy of the phosphoanhydride bond in atp or nad(+) and assistance of a divalent metal cofactor mg(2+). molecular details of ligase catalysis are essential for understanding the mechanism of metal-promoted phosphoryl transfer reactions in the living cell responsible for a wide range of processes, e.g., dna replication and transcription, signaling and differentiation, energy coupling and metabolism. here we report a single-turnover (31)p solid-state ... | 2008 | 18562298 |
| inverse correlation between nkg2d expression on cd8+ t cells and the frequency of cd4+cd25+ regulatory t cells in patients with esophageal cancer. | although malignant diseases are known to be associated with immune suppression, detailed mechanisms of this phenomenon are still unknown. nkg2d is an activating cell surface receptor expressed by natural killer (nk) cells and cd8+ t cells, and it has been reported that nkg2d engagement is extremely important for t cell activation. in the current study, nkg2d expression on cd8+ t cells and the frequency of cd4+ cd25+ regulatory t (treg) cells were determined by multicolor flow cytometry to invest ... | 2009 | 18564160 |
| [effect of exogenous thyroxin on renal ion-regulating and acid-secreting functions in white rats]. | experimental hyperthyreosis was stimulated by intraventricular injections of sodium solithyroxin (t4) suspension on 1% starch gel during 10 days at a dose of 10 microg/100 g of body mass (n = 15) or 20 microg/100 g of body mass (n = 15). renal function was tested by 5 % water loading after 24 hrs. since the last t4 injection. urine and blood plasma samples were analyzed for creatinine; in addition, urine was analyzed for sodium and potassium ions of titrated acids, ammonium cations, and ph. thyr ... | 2008 | 18564575 |
| modulation of t4 gene 32 protein dna binding activity by the recombination mediator protein uvsy. | bacteriophage t4 uvsy is a recombination mediator protein that promotes assembly of the uvsx-ssdna presynaptic filament. uvsy helps uvsx to displace t4 gene 32 protein (gp32) from ssdna, a reaction necessary for proper formation of the presynaptic filament. here we use dna stretching to examine uvsy interactions with single dna molecules in the presence and absence of gp32 and a gp32 c-terminal truncation (*i), and show that in both cases uvsy is able to destabilize gp32-ssdna interactions. in t ... | 2008 | 18565541 |
| thyroid hormone transport and metabolism by organic anion transporter 1c1 and consequences of genetic variation. | organic anion transporting polypeptide (oatp) 1c1 has been characterized as a specific thyroid hormone transporter. based on its expression in capillaries in different brain regions, oatp1c1 is thought to play a key role in transporting thyroid hormone across the blood-brain barrier. for this reason, we studied the specificity of iodothyronine transport by oatp1c1 in detail by analysis of thyroid hormone uptake in oatp1c1-transfected cos1 cells. furthermore, we examined whether oatp1c1 is rate l ... | 2008 | 18566113 |
| the success rate of i-131 ablation in differentiated thyroid cancer: comparison of uptake-related and fixed-dose strategies. | the aim of the study was to compare the success rate of an uptake-related ablation protocol in which the dose depends on an i-131 24-h neck uptake measurement and a fixed-dose ablation protocol in which the dose depends on tumour stage. | 2008 | 18567668 |
| assessment of thyroid function: towards an integrated laboratory--clinical approach. | laboratory assessment of thyroid function is now often initiated with a low pre-test probability, by clinicians who may not have a detailed knowledge of current methodology or testing strategies. skilled laboratory staff can significantly enhance the choice of appropriate tests and the accuracy of clinical response; such involvement requires both appropriate training and relevant information from the clinician. measurement of the serum thyroid stimulating hormone (tsh) concentration with an assa ... | 2003 | 18568049 |
| a rapid and sensitive chemiluminescent immunoassay of total thyroxin with dmae x nhs-labeled. | a novel chemiluminescence immunoassay (clia) of total thyroxin (tt4) with the acridinium ester of dmae x nhs [2',6'-dimethyl-4'-(n-succinimidyloxycarbonyl) phenyl-10-methyl-acridinium-9-carboxylate methosulfate] labeled has been developed. in our method, microwells were coated with anti-t4 monoclonal antibody (mcab) and dmae x nhs synthesized by our laboratory was conjugated with streptavidin (sa). t4-bsa was conjugated with biotin-n-hydroxysuccinimide (b x nhs), t4-bsa- b x nhs and the t4 in th ... | 2008 | 18569374 |
| evaluation of prostate cancer characteristics in four populations worldwide. | prostate cancer is common around the world, but rates of advanced disease differ substantially by race and geography. although a major health issue, little is known about prostate cancer presentation in west africa and india compared to the united states (us). | 2008 | 18570709 |
| ultrasound appearance of thyroid tissue in hypothyroid infants. | to identify those infants who need a higher starting dose of levothyroxine (l-t4) for early normalization of thyroid-stimulating hormone (tsh) level. | 2008 | 18571545 |
| [adjuvant chemotherapy followed by conformal chemoradiotherapy in gastric carcinoma]. | analysis of the feasibility and results of adjuvant chemotherapy followed by conformal chemoradiotherapy after surgery for gastric carcinoma. | 2008 | 18571967 |
| convergent mechanisms of genome evolution of large and giant dna viruses. | we have taken advantage of the availability of the genome sequences of a collection of large and giant viruses infecting bacteria (t4 family) and eukaryotes (ncldv group) to assess some of the evolutionary forces which might have shaped their genomes. despite having apparently different ancestors, these two groups of viruses are affected by convergent evolutionary forces. both types of virus probably originated from a simple and ancient viral ancestor with a small subset of 30-35 genes encoding ... | 2008 | 18572389 |
| the prognostic value of lymph node metastases and tumour regression grade in rectal cancer patients treated with long-course preoperative chemoradiotherapy. | the purpose of the present study was to investigate the impact of tumour regression and the post-treatment lymph node status on the prognosis of rectal cancer treated by preoperative neoadjuvant chemoradiotherapy. | 2009 | 18573119 |
| treatment of patients with clinically lymph node-negative squamous cell carcinoma of the oral cavity. | to evaluate treatment outcome and to determine optimal treatment strategy for patients with clinically lymph node-negative (n0) oral cavity squamous cell carcinoma (scc). | 2008 | 18573849 |
| sentinel node concept in clinically n0 laryngeal and hypopharyngeal cancer. | sentinel nodes (sns) are the lymph nodes that directly receive lymphatic flow from a primary cancer lesion. the sn concept implies that lymphatic metastasis initially occurs at sns. sn navigation surgery can be introduced for cancers in which the sn concept is established. in sn navigation surgery, lymph node dissection beyond sns can be omitted if sns are metastasis free. although the sn concept has been investigated frequently for oral and oropharyngeal cancer, it has so far been investigated ... | 2008 | 18574637 |
| analysis of the k-ras/b-raf/erk signal cascade, p53 and cmap as markers for tumor progression in colorectal cancer patients. | colorectal cancer patients may succumb to their disease because of local recurrence or formation of metastasis. to develop a prognostic tool for these fatal types of progression, 23 patients with colorectal carcinoma were included in this study for the detection at the time of surgery of the incidence of k-ras, b-raf and p53 mutations, the phosphorylation status of erk and the expression of cystatin-like metastasis-associated protein (cmap) in tumor, mucosa and liver samples. polymerase chain re ... | 2008 | 18575712 |
| potential energy surfaces for all-trans p5h6(+) and p5me6(+) may be less complicated than anticipated. | burford and co-workers recently (2007) investigated the synthesis, structure, and pseudorotation of a family of cyclotetraphosphinophosphonium ions comprehensively. we now report theoretical computations through the ccsd(t) level to study the conformations of the parent model rings, p5h6(+) and p5me6(+). the all-trans conformations on the full pseudorotational cycle for the cyclotetraphosphinophosphonium cation (p5h6(+)) and for its methyl-substituted derivative (p5me6(+)) were located systemati ... | 2008 | 18576644 |
| the odyssey of nontoxic nodular goiter (ntng) in greece under suppression therapy, and after improvement of iodine deficiency. | nontoxic nodular goiter (ntng) is common in endemic goiter regions. thyroxine (t4) is often used to treat ntng. there is little information regarding t4 treatment in regions that have recently become iodine sufficient. we studied the effect of t4 treatment on thyroid function tests in southwestern greece (swg), a recently iodine-sufficient area. | 2008 | 18578614 |
| efficacy of contact lens systems against recent clinical and tap water acanthamoeba isolates. | a recent increase in acanthamoeba keratitis (ak) cases has been associated with complete moistureplus, although many cases used other solutions. complete moistureplus contains taurine and hydroxypropyl methylcellulose, unlike other multipurpose solutions (mpss). the purpose of this study is to (1) determine contact lens solution efficacy against recent clinical and tap water acanthamoeba isolates and (2) determine whether taurine inclusion increases acanthamoeba survival against contact lens sol ... | 2008 | 18580265 |
| [surgical results of t4 lung cancer invading left atrium and great vessels]. | to analyzed the indication and prognostic factors of surgical treatment of lung cancer invading left atrium and great vessels (t4). | 2008 | 18581890 |
| mechanism of trifluralin-induced thyroid tumors in rats. | trifluralin, an herbicide, has been reported to cause a significant increase in thyroid follicular cell tumors in male fischer 344 rats. this study was designed to determine the mechanism of thyroid hyperactivity after trifluralin exposure. a group of 15 male fischer 344 rats were exposed to trifluralin-fortified (6500 ppm) diet for 2 weeks. the time weighted average daily intake of trifluralin was 441+/-77 mg/kg/day. ten rats of the group were sacrificed and the sera analyzed for t3, t4, and ts ... | 2008 | 18582544 |
| multiple segmental and selective isotope labeling of large rna for nmr structural studies. | multiple segmental and selective isotope labeling of rna with three segments has been demonstrated by introducing an rna segment, selectively labeled with (13)c(9)/(15)n(2)/(2)h((1', 3', 4', 5', 5''))-labeled uridine residues, into the central position of the 20 kda epsilon-rna of duck hepatitis b virus. the rna molecules were produced via two efficient protocols: a two-step protocol, which uses t4 dna ligase and t4 rna ligase 1, and a one-pot protocol, which uses t4 rna ligase 1 alone. with t4 ... | 2008 | 18583361 |
| carbaryl, 1-naphthol and 2-naphthol inhibit the beta-1 thyroid hormone receptor-mediated transcription in vitro. | effects of pesticides on the function of thyroid have attracted lots of attention because thyroid hormones (ths) play a major role in mammalian brain development. in order to screen for compounds that acted on the thyroid hormone receptor (tr) signaling pathway, we transiently transfected the vector pgal4-l-trbeta1 (gal4 dbd fused to htrbeta1 lbd) and gal4-responsive luciferase reporter puas-tk-luc into hepg2 cell, developing a reporter gene assay which showed good response to triiodothyronine ( ... | 2008 | 18584933 |
| rna-templated single-base mutation detection based on t4 dna ligase and reverse molecular beacon. | a novel rna-templated single-base mutation detection method based on t4 dna ligase and reverse molecular beacon (rmb) has been developed and successfully applied to identification of single-base mutation in codon 273 of the p53 gene. the discrimination was carried out using allele-specific primers, which flanked the variable position in the target rna and was ligated using t4 dna ligase only when the primers perfectly matched the rna template. the allele-specific primers also carried complementa ... | 2008 | 18585229 |
| first- and second-trimester thyroid hormone reference data in pregnant women: a faster (first- and second-trimester evaluation of risk for aneuploidy) research consortium study. | the purpose of this study was to calculate first and second trimester reference ranges and within-woman correlations for tsh, free t4, and thyroid antibodies. | 2008 | 18585522 |
| vertebral fracture assessment in healthy men: prevalence and risk factors. | vertebral fracture assessment (vfa) is a technology that can reliably and accurately diagnose vertebral fractures with greater patient convenience, less radiation exposure, and lower cost than standard spine radiography. | 2008 | 18585994 |
| modulation of the packaging reaction of bacteriophage t4 terminase by dna structure. | bacteriophage terminases package dna through the portal ring of a procapsid during phage maturation. we have probed the mechanism of the phage t4 large terminase subunit gp17 by analyzing linear dnas that are translocated in vitro. duplex dnas of random sequence from 20 to 500 bp were efficiently packaged. dye and short, single-stranded end extensions were tolerated, whereas 20-base extensions, hairpin ends, 20-bp dna-rna hybrid, and 4-kb dsrna substrates were not packaged. molecules 60 bp long ... | 2008 | 18586272 |
| an examination of the flexion-relaxation phenomenon in the cervical spine in lumbo-pelvic sitting. | the flexion-relaxation phenomenon (frp) is well documented at end-range lumbar spine flexion in both standing and sitting however, the frp has been insufficiently investigated in cervico-thoracic musculature. the aim of this study was to determine whether the frp occurs during forward flexion of the neck, in lumbo-pelvic sitting, amongst a pain-free population. surface electromyography (emg) was used to measure muscle activation in 20 (10 men, 10 women) asymptomatic subjects in selected cervico- ... | 2009 | 18586519 |
| the genotypic characterisation of acanthamoeba isolates from human ocular samples. | we characterised 37 amoebae cultured from corneal scrapings, contact lenses or lens case solutions of patients with suspected acanthamoeba keratitis. | 2008 | 18586902 |
| induction of t4 dna ligase in a recombinant strain of escherichia coli. | the kinetics of cell growth and foreign protein production, as well as factors affecting protein stability, were studied and optimized in batch and fed-batch fermentations of a recombinant strain of escherichia coli. the pl promoter from bacteriophage lambda under the control of a temperature-sensitive cl represser, with the entire construct integrated into the e. coli chromosome through the use of a defective bacteriophage lambda lysogen, was used to direct the synthesis of t4 dna ligase. the b ... | 1989 | 18588013 |
| allan-herndon-dudley syndrome. | allan-herndon-dudley syndrome (ahds) is a rare x-linked disorder caused by mutation in the gene encoding the monocarboxylate transporter-8. abnormal transport function is reflected by elevated free t3 and decreased free t4 levels along with clinical features characterized by neurological abnormalities including global developmental delay, central hypotonia, rotatory nystagmus, impaired hearing, spasticity and contractures of joints. we report a child with classical clinical features along with c ... | 2008 | 18589880 |
| variable region of betanodavirus rna2 is sufficient to determine host specificity. | betanodaviruses, the causative agents of viral nervous necrosis in marine fish, have bipartite positive-sense rna genomes. the viruses have been classified into 4 distinct types based on nucleotide sequence similarities in the variable region (the so-called t4 region) of the smaller genomic segment rna2 (1.4 kb). betanodaviruses have marked host specificity, although the primary structures of the viral rnas and encoded proteins are similar among the viruses. we have previously demonstrated, usin ... | 2008 | 18589996 |
| [determining the thyroid hormones t3 and t4 in the urine: an unreliable test for hypothyroidism]. | | 2008 | 18590068 |
| posterior midline approach for single-stage en bloc resection and circumferential spinal stabilization for locally advanced pancoast tumors. technical note. | the treatment of pancoast (superior sulcus) tumors that extensively invade the vertebral column remains controversial. different surgical approaches involving multistage resection techniques have been previously described for superior sulcus tumors that invade the chest wall and spinal column. typically a posterior approach to stabilize the spine is followed by a second-stage thoracotomy (posterolateral or trap door) for definitive en bloc resection of stage t4 pancoast tumors. the authors repor ... | 2008 | 18590415 |
| maternal thyroid hypofunction and pregnancy outcome. | to estimate whether maternal thyroid hypofunction is associated with complications. | 2008 | 18591312 |
| potassium perchlorate only temporarily restores euthyroidism in patients with amiodarone-induced hypothyroidism who continue amiodarone therapy. | amiodarone-induced hypothyroidism (aih) may occur in patients with or without underlying thyroid disorders. in the latter, restoration of euthyroidism, after amiodarone discontinuation, can be facilitated and accelerated by a short course of potassium perchlorate (kclo4). however, it is unknown whether kclo4 may exert similar effects on thyroid function of aih patients if amiodarone treatment is continued. | 2008 | 18591883 |
| commentary: discordant measurements of serum triiodothyronine (t4), thyroxine (t3) and thyroid-stimulating hormone (tsh). | | 2008 | 18593966 |
| tissue factor expression in non-small cell lung cancer: relationship with vascular endothelial growth factor expression, microvascular density, and k-ras mutation. | tissue factor (tf) is the physiological trigger of blood coagulation, but it could also have an important role in cancer by regulating vegf expression and angiogenesis. | 2008 | 18594312 |
| biomechanical contribution of transverse connectors to segmental stability following long segment instrumentation with thoracic pedicle screws. | an in vitro biomechanical cadaver study of long segment thoracic pedicle screw constructs with transverse connectors (tc). | 2008 | 18594445 |
| evaluation of the bard bta-test in the diagnosis of upper urinary tract tumours. | the bta-test is an agglutination assay that qualitatively detects the presence of complexes of basement membrane within the urine of patients with bladder cancer. however, the significance of bta test in other urotelial tumours has not been extensively studied. therefore, in the present research, we examined the validity of bta-test in patients suffering from ureteral or renal pelvis cancer, and compare results with urincitology. 35 patients were included in this study (13 with ureteral and 22 w ... | 2007 | 18595223 |
| chemotherapy by m-vac protocol in progressive bladder carcinoma treatment. | treatment of invasive bladder carcinoma is complex therapy procedure which means surgical and non-surgical treatment appliance. in spite of radical surgical treatment conduction, the gold standard in invasive bladder tumor therapy, about 30-40% patients spread metastasis in further disease course. the system chemotherapy in invasive bladder tumors treatments is marked with accent. its fundamental aim is to correct results of surgical treatment. this therapy option very often means the only modal ... | 2007 | 18595238 |
| quality of life after sentinel lymph node biopsy or axillary lymph node dissection in stage i/ii breast cancer patients: a prospective longitudinal study. | breast cancer patients' quality of life (qol) after surgery has been reported to improve significantly over time. little is known about qol recovery after sentinel lymph node biopsy (slnb) in comparison to axillary lymph node dissection (alnd). | 2008 | 18597146 |
| a novel therapeutic paradigm to treat congenital hypothyroidism. | to determine the effectiveness of a novel therapeutic paradigm to treat congenital hypothyroidism (ch) incorporating variable initial doses of l-t4 based on the underlying aetiology and frequent monitoring, up to 2 years of age. | 2008 | 18598275 |
| decrease of evoked delta, theta and alpha coherences in alzheimer patients during a visual oddball paradigm. | in this study event related coherence of patients with alzheimer type of dementia (ad) was analyzed by using a visual oddball paradigm as stimuli. a total of 21 mild probable ad subjects (10 untreated, 11 treated) were compared with a group of 19 healthy controls. the members of the groups had their eeg recorded from 12 electrodes by means of a visual oddball paradigm. the evoked coherence was analyzed for delta (1-3.5 hz), theta (4-7 hz) and alpha (8-13 hz) frequency ranges for inter-hemispheri ... | 2008 | 18598686 |
| preventive wrapping of the fragile tracheobronchial wall using a flap of latissimus dorsi muscle during esophagectomy after chemoradiotherapy. | thanks to significant recent progress in the application of chemoradiotherapy (crt) in the treatment of esophageal cancer, the numbers of operations on patients who have undergone preoperative crt are increasing. in these patients, preoperative crt often leads to formation of an unstable, scleroid layer comprised of what appears to be scar tissue around the tracheobronchial wall. this scleroid layer must be removed with the tumor, thereby weakening the wall. | 2008 | 18600026 |
| neurodevelopmental and neurophysiological actions of thyroid hormone. | for over 100 years, thyroid hormones have been known to be essential for neonatal neurodevelopment but whether they are required by the foetal brain remains a matter of controversy. for decades, the prevailing view was that thyroid hormones are not necessary until after birth because circulating levels in the foetus are very low and the placenta forms an efficient barrier to their transfer from the mother. clinical observations of good neurological outcome following early treatment of congenital ... | 2008 | 18601701 |
| prognostic factors for lymph node metastasis from advanced squamous cell carcinoma of the skin of the trunk and extremities. | squamous cell carcinoma (scc) of the skin of the trunk and extremities may present lymph node metastasis with difficult disease control and poor survival. the purpose of this study was to identify risk factors for lymph node metastasis and outcome. | 2008 | 18601735 |
| infertility in the cycling queen: seven cases. | in this study we examined seven queens with normal oestrous cycles and a history of infertility after normal matings. we performed clinical examination, vaginal cytology, evaluation of oestradiol, progesterone and total t4 levels, vaginal bacterial culture, ultrasonography, and serum analyses for detection of antibodies against chlamydia and feline leukaemia virus (felv) antigenemia. ovariohysterectomy (ohe) was recommended for 1/7 queens because of pathological uterine changes detected at ultra ... | 2008 | 18602323 |
| thyroid dysfunction in down syndrome. | down syndrome is associated with various forms of thyroid dysfunction, hypothyroidism being the most common. the additive effects of both co-morbid conditions lead to further amplification of the clinical problems in these children with down syndrome. | 2006 | 18603895 |
| a study of therapeutic effect of the growth of children with hypothyroidism. | this study was done to see the therapeutic effect of the growth of children who was diagnosed as hypothyroidism. | 2006 | 18603928 |
| altered serum levels of thyroxine, triiodothyroinine and thyroid stimulating hormone in patients with depression. | to assess serum level of thyroxine (t4), triiodothyronine(t3) and thyroid stimulating hormone(tsh) in patient with depression. | 2007 | 18604049 |
| acupuncture treatment of dysmenorrhea resistant to conventional medical treatment. | we evaluated the effect of acupuncture on nsaid resistant dysmenorrhea related pain [measured according to visual analogue scale (vas)] in 15 consecutive patients. pain was measured at baseline (t1), mid treatment (t2), end of treatment (t3) and 3 (t4) and 6 months (t5) after the end of treatment. substantial reduction of pain and nsaid assumption was observed in 13 of 15 patients (87%). pain intensity was significantly reduced with respect to baseline (average vas = 8.5), by 64, 72, 60 or 53% a ... | 2008 | 18604253 |
| apobec3g and apobec3f require an endogenous cofactor to block hiv-1 replication. | apobec3g (a3g)/apobec3f (a3f) are two members of apobec3 cytidine deaminase subfamily. although they potently inhibit the replication of vif-deficient hiv-1, this mechanism is still poorly understood. initially, a3g/a3f were thought to catalyze c-to-u transitions on the minus-strand viral cdnas during reverse transcription to disrupt the viral life cycle. recently, it was found more likely that a3g/a3f directly interrupts viral reverse transcription or integration. in addition, a3g/a3f are both ... | 2008 | 18604271 |
| [neonatal screening program for congenital hypothyroidism in northeast of brazil: criteria, diagnosis and results]. | it was evaluated the concentration of tsh in blood spot (tshneo) of 48,039 children included in the neonatal screening program (nsp) for congenital hypothyroidism (ch) of sergipe (se), a state in the northeast of brazil. it was also evaluated the concentration of serum tsh, total t4 and free t4 in the recalled children suspicious of having ch, their age in several phases of the program, the covering and frequency of the nsp in the cases from january 2005 to august 2006, comparing them with liter ... | 2008 | 18604374 |
| electronic properties of star-shaped oligofluorenes containing an isotruxene core: interplay of para and ortho conjugation effects in phenylene-based pi systems. | the synthesis, photophysics, cyclic voltammetry, spectroelectrochemistry, and electrogenerated chemiluminescence (ecl) properties of a series of unsymmetrical star-shaped oligophenylenes it1-it4 are reported. the electronic couplings among the three oligofluorene arms in it1-it4 are strong due to the para-ortho branched isotruxene core. the ortho conjugation effect results in band splitting in the absorption spectra for both the neutral and the radical ionic form with a stronger effect for the l ... | 2008 | 18605684 |
| lateral pharyngotomy extended by resection of the mandibular angle-an alternative approach to the surgical treatment of oropharyngeal (tonsillar) cancers. | the authors found the procedure, when used with the proper indications, to be an uncomplicated and expeditious method that presents little risk to surrounding structures, has no residual cosmetic or functional consequences for the patient, presents a low risk of complications, and has a good oncological outcome. the main indications for this procedure are related to the extent of the tumour and the surgeon's experience with the method. | 2009 | 18607919 |
| surgery alone for squamous cell carcinoma of the oral cavity: survival rates, recurrence patterns, and salvage treatment. | surgery alone may be a reliable and feasible treatment of choice in selected patients with squamous cell carcinoma (scc) of the oral cavity, given the proper indications. | 2008 | 18607922 |
| how good is endoscopic ultrasound for tnm staging of gastric cancers? a meta-analysis and systematic review. | to evaluate the accuracy of endoscopic ultrasound (eus) for staging of gastric cancers. | 2008 | 18609685 |
| studies on phage development. ii. the maturation of t4 phage in the presence of puromycin. | maturation of t4 can proceed in the presence of 5-methyltryptophan or puromycin. puromycin inhibits phage protein synthesis within a few seconds, thus limiting the amount of phage precursor material available for maturation. after the arrest of protein synthesis, maturation continues unabated until the limiting protein precursor is depleted. at least one protein, the tail fiber protein, is depleted. phage protein maturable in the presence of puromycin appears about 5 minutes before maturation be ... | 1966 | 18611470 |
| studies on phage development. iii. the fate of t4 dna and protein synthesized in the presence of 9-aminoacridine. | 9-aminoacridine (9aa) inhibits maturation of phage t4. upon diluting infected bacteria from the dye into a medium containing an inhibitor of protein synthesis, one obtains a crop of mature phage made out of the material accumulated before the removal of 9aa. dna is synthesized in the presence of 9aa and continues to replicate after the removal of 9aa and addition of puromycin. by marking the dna with 5-bromodeoxyuridine (budr) and studying the light sensitivity of the phage produced by cells exp ... | 1966 | 18611471 |
| genetic loci linked to pituitary-thyroid axis set points: a genome-wide scan of a large twin cohort. | previous studies have shown that circulating concentrations of tsh, free t4, and free t3 are genetically regulated, but the genes responsible remain largely unknown. the aim of this study was to identify genetic loci associated with these parameters. | 2008 | 18611976 |
| identifying and genotyping transgene integration loci. | the random germline integration of genetically engineered transgenes has been a powerful technique to study the role of particular genes in variety of biological processes. although the identification of the transgene insertion site is often not essential for functional analysis of the transgene, identifying the site can have practical benefit. enabling one to distinguish between animals that are homozygous or hemizygous for the transgene locus could facilitate breeding strategies to produce ani ... | 2008 | 18612840 |
| peripartal feeding strategy with different n-6: n-3 ratios in sows: effects on sows' performance, inflammatory and periparturient metabolic parameters. | the present study aimed to investigate the effects of two lactation sow feeds, differing in n-6:n-3 ratio, given to sows before parturition on body condition and feed intake, periparturient metabolism (leptin, insulin, triiodothyronine (t3) and thyroxine (t4)), inflammatory parameters (tnfalpha, il-6, serum amyloid a (saa)) and on piglet performance (birth weight, survivability). the feed contained either a low (supplemented with fish oil; f groups) or high (supplemented with sunflower-seed oil; ... | 2009 | 18613985 |
| streptomycin suppression of ambivalent phage mutations. | phenotypic repair by streptomycin has been studied in amber mutants of phage t4 on su- strains, as has the interference of smr mutations with amber suppressors. the repair seems not to be specific; however a temporal specificity of streptomycin action has been demonstrated by means of pulse experiments. the dependence of the efficiency of suppression upon experimental condition is also reported. | 1967 | 18614055 |
| effect of phage on amino acid activation. | infection of escherichia coli np2 with t-even phage strains is known to cause the appearance of a new valyl trna synthetase activity. in the present work mutant hosts possessing altered activating enzymes for phenylalanine, glycine, or histidine were employed to detect possible phage-induced modifications in the translating systems for these amino acids. the results establish that t4 has an absolute requirement for the phenylalanyl trna synthetase of its host, probably in an unmodified form, and ... | 1967 | 18614089 |
| the luria-latarjet effect studied by t4-lysozyme production. | the replication of bacteriophage t4 in escherichia coli is sensitive to ultraviolet light (uv). the classical plaque assay shows a considerable increase in uv resistance starting at about 5 minutes after the bacteria are infected. production of phage lysozyme starts about 10 minutes after infection and is sensitive to irradiation. its uv resistance increases at about 4 minutes. the appearance of resistance, measured by both the plaque assay and lysozyme production, is inhibited by p-fluorophenyl ... | 1968 | 18614109 |
| an animal model to study health effects during continuous low-dose exposure to the nerve agent vx. | in the present study, we have developed an animal model to study long-term health effects of continuous exposure of toxic chemical agents, in awake, freely moving rats. the aim was to evaluate the effect of low-dose exposure of the nerve agent vx, and to find specific biomarkers for intoxication. to exclude the influence of stress, we used an implanted radio-telemetric device for online registration of physiological parameters, and an osmotic pump, implanted subcutaneously, for continuous exposu ... | 2008 | 18614271 |
| a modern regimen of pre-operative concurrent chemo-radiation therapy in locally advanced rectal cancer. | to evaluate the efficacy and toxicity of preoperative concurrent capecitabine and radiotherapy in the treatment of resectable locally advanced rectal cancer (larc). | 2008 | 18615536 |
| definitive radiation therapy for squamous cell carcinoma of the soft palate. | we report the university of florida experience with soft-palate carcinoma treated with radiotherapy alone or combined with adjuvant chemotherapy and/or neck dissection for residual disease in the neck. | 2008 | 18615732 |