| staphylococcus aureus primase has higher initiation specificity, interacts with single-stranded dna stronger, but is less stimulated by its helicase than escherichia coli primase. | the study of primases from model organisms such as escherichia coli, phage t7 and phage t4 has demonstrated the essential nature of primase function, which is to generate de novo rna polymers to prime dna polymerase. however, little is known about the function of primases from other eubacteria. their overall low primary sequence homology may result in functional differences. to help understand which primase functions were conserved, primase and its replication partner helicase from the pathogeni ... | 2008 | 18452509 |
| predictors of positive radial margin status in a population-based cohort of patients with rectal cancer. | surgical margin status is an important predictor of risk of relapse among patients with rectal cancer. | 2008 | 18454185 |
| dissection of the bacteriophage t4 late promoter complex. | activated transcription of the bacteriophage t4 late genes is generated by a mechanism that stands apart from the common modalities of transcriptional regulation: the activator is gp45, the viral replisome's sliding clamp; two sliding-clamp-binding proteins, gp33 and gp55, replace the host rna polymerase (rnap) sigma subunit. we have mutagenized, reconfigured and selectively disrupted individual interactions of the sliding clamp with gp33 and gp55 and have monitored effects on transcription. the ... | 2008 | 18455735 |
| repetitive tms combined with exposure therapy for ptsd: a preliminary study. | treatment for anxiety and post-traumatic stress disorder (ptsd) includes exposure therapy and medications, but some patients are refractory. few studies of repetitive transcranial magnetic stimulation (rtms) for anxiety or ptsd exist. in this preliminary report, rtms was combined with exposure therapy for ptsd. nine subjects with chronic, treatment-refractory ptsd were studied in a placebo-controlled, crossover design of imaginal exposure therapy with rtms (1hz) versus sham. ptsd symptoms, serum ... | 2009 | 18455908 |
| topoisomerase iialpha gene status and prediction of pathological complete remission after anthracycline-based neoadjuvant chemotherapy in endocrine non-responsive her2/neu-positive breast cancer. | topoisomerase iialpha (topo ii) is a potential marker of responsiveness to anthracycline-based therapy. we analyzed the role of topo ii gene status in the prediction of pathological complete remission (pcr) after primary anthracycline-based chemotherapy in non- endocrine responsive breast cancers overexpressing her2/neu. | 2008 | 18456496 |
| effect of high versus low initial doses of l-thyroxine for congenital hypothyroidism on thyroid function and somatic growth. | the optimal dose of thyroxine (t4) in congenital hypothyroidism (ch) during infancy is controversial. higher doses lead to improvement in cognitive scores, but have been linked to later behavioural difficulties. we have examined the effects of initial t4 dosage on somatic growth--a putative surrogate marker of overtreatment. | 2008 | 18456702 |
| regression supports two mechanisms of fork processing in phage t4. | replication forks routinely encounter damaged dna and tightly bound proteins, leading to fork stalling and inactivation. to complete dna synthesis, it is necessary to remove fork-blocking lesions and reactivate stalled fork structures, which can occur by multiple mechanisms. to study the mechanisms of stalled fork reactivation, we used a model fork intermediate, the origin fork, which is formed during replication from the bacteriophage t4 origin, ori(34). the origin fork accumulates within the t ... | 2008 | 18456838 |
| reference intervals for tsh and thyroid hormones are mainly affected by age, body mass index and number of blood leucocytes, but hardly by gender and thyroid autoantibodies during the first decades of life. | the purpose of our study was to establish reference intervals for thyroid function tests in children and adolescents and to identify factors that may influence the limits of these intervals. | 2008 | 18457671 |
| difficult thoracic pedicle screw placement in adolescent idiopathic scoliosis. | retrospective radiographic and clinical consecutive case series. | 2008 | 18458588 |
| usefulness of the nutrient foramen of lamina for insertion of thoracic pedicle screws. | a cadaveric study. | 2008 | 18458591 |
| repairing dna damage in xeroderma pigmentosum: t4n5 lotion and gene therapy. | patients with xeroderma pigmentosum (xp) have defective dna repair and are at a high risk for cutaneous malignancies. standard treatments for xp are limited in scope and effectiveness. understanding the molecular etiology of xp has led to the development of novel therapeutic approaches, including enzyme and gene therapies. one new topical treatment utilizing bacteriophage t4 endonuclease 5 (t4n5) in a liposomal lotion is currently in clinical trials and has received a fast track designation from ... | 2008 | 18459526 |
| uv-induced dna damage initiates release of mmp-1 in human skin. | destruction of collagen is a hallmark of photoaging. the major enzyme responsible for collagen 1 digestion, matrix metalloproteinase-1 (mmp-1), is induced by exposure to sunlight. to study the molecular trigger for this induction, human skin was ultraviolet-b (uvb)-irradiated and treated with liposome-encapsulated dna repair enzymes. the photolyase-mediated dna repair of epidermal uv damage was associated with a reduction of mmp-1 mrna and protein expression in both the epidermal and dermal comp ... | 2008 | 18459971 |
| ingestion without inactivation of bacteriophages by tetrahymena. | tetrahymena has been shown to ingest and inactivate bacteriophages, such as t4, in co-incubation experiments. in this study, tetrahymena thermophila failed to inactivate phages phix174 and ms2 in co-incubations, although phix174 were ingested by t. thermophila, as demonstrated by: (1) recovery at defecation in a pulse-chase experiment, (2) recovery from tetrahymena by detergent lysis, and (3) transmission electron microscopy. we conclude, therefore, that the phages must be digestion-resistant. i ... | 2008 | 18460158 |
| comparative disinfection efficiency of pulsed and continuous-wave uv irradiation technologies. | pulsed uv (puv) is a novel uv irradiation system that is a non-mercury lamp-based alternative to currently used continuous-wave systems for water disinfection. puv polychromatic irradiation disinfection efficiency was compared to that from continuous-wave monochromatic low-pressure (lp) and polychromatic medium-pressure (mp) uv systems, using two types of actinometry (ferrioxalate and iodide-iodate) and an absolute spectral emission method for fluence measurement. all three methods were in good ... | 2008 | 18460414 |
| extramural vascular invasion is an adverse prognostic indicator of survival in patients with colorectal cancer. | extramural vascular invasion (evi) in colorectal cancer is reported to be a stage-independent adverse prognostic factor, and is a core item in the royal college of pathologists minimum data set for colorectal cancer histopathology reporting. the detection of evi is also highly variable amongst pathologists. our aims were to analyse both the frequency of evi in colorectal cancer resections, and the effect of evi on survival, in patients operated on over a 5-year period. | 2009 | 18462242 |
| prediction of cure and risk of hypothyroidism in patients receiving 131i for hyperthyroidism. | there is little consensus regarding the most appropriate dose of radioiodine ((131)i) to be administered to patients with hyperthyroidism. | 2009 | 18462261 |
| the effect of perineural invasion on overall survival in patients with gastric carcinoma. | the availability of different treatment options for gastric carcinoma has reopened the question of correct definition of high-risk categories, which may help in identifying patients with high risk for poor prognosis who would benefit more from adjuvant therapy after operation. perineural invasion (pni) seems to provide useful information for management. therefore, we examined the effect of pni on overall survival (os) in patients with gastric carcinoma and the association between pni and other c ... | 2008 | 18463928 |
| the effect of famotidine, esomeprazole, and ezetimibe on levothyroxine absorption. | recent literature describing the effect of gastric acid suppression on levothyroxine absorption has been inconsistent. also, ezetimibe, a lipid-lowering compound that inhibits intestinal absorption of cholesterol, may interfere with levothyroxine absorption. the objective of this study was to measure changes in levothyroxine absorption before and after famotidine, esomeprazole or single-dose ezetimibe." | 2008 | 18466075 |
| regulation of tissue iodothyronine deiodinase activity in a model of prolonged critical illness. | the low plasma triiodothyronine (t3) observed during prolonged critical illness can be explained in part by suppressed hepatic deiodinase type i (d1) and increased d3 activity. infusion of thyrotropin-releasing hormone (trh) can restore d1 and d3 activity in critically ill rabbits, but it remains unknown whether this is a direct effect of trh or the trh-induced rise in circulating thyroxine (t4) and t3. | 2008 | 18466079 |
| the effects of medetomidine on the action of vecuronium in dogs anaesthetized with halothane and nitrous oxide. | to quantify the effects of medetomidine on the onset and duration of vecuronium-induced neuromuscular blockade in dogs. | 2008 | 18466163 |
| thyroid autoimmunity in children with features of both type 1 and type 2 diabetes. | to assess the prevalence of autoimmune thyroid disease (atd) in insulin-treated youth with clinical features of type 2 diabetes mellitus (t2dm). | 2008 | 18466208 |
| functional organ preservation with definitive chemoradiotherapy for t4 laryngeal squamous cell carcinoma. | randomized trials established chemoradiotherapy as standard treatment for advanced laryngeal cancer. patients with large-volume t4 disease (lvt4) were excluded from these trials. the purpose of this study was to report t4 laryngeal cancer patient outcome, including those with lvt4 disease, treated with chemoradiotherapy. | 2008 | 18467314 |
| maternal thyroid hormone: a strong repressor of neuronal nitric oxide synthase in rat embryonic neocortex. | understanding of how maternal thyroid inadequacy during early gestation poses a risk for developmental outcomes is still a challenge for the neuroendocrine community. early neocortical neurogenesis is accompanied by maternal thyroid hormone (th) transfer to fetal brain, appearance of th receptors, and absence of antineurogenesis signals, followed by optimization of neuronal numbers through apoptosis. however, the effects of th deprivation on neurogenesis and neuronal cell death before the onset ... | 2008 | 18467447 |
| upper urinary tract transitional cell carcinoma. a 10-year experience. | to present our 10-year experience with patients surgically treated for upper urinary tract transitional cell carcinoma. | 2008 | 18468339 |
| iodothyronine deiodinase enzyme activities in bone. | euthyroid status is essential for normal skeletal development and maintenance of the adult skeleton, but the mechanisms which control supply of thyroid hormone to bone cells are poorly understood. thyroid hormones enter target cells via monocarboxylate transporter-8 (mct8), which provides a functional link between thyroid hormone uptake and metabolism in the regulation of t3-action but has not been investigated in bone. most circulating active thyroid hormone (t3) is derived from outer ring deio ... | 2008 | 18468505 |
| serum concentrations of adiponectin in patients with hyperthyroidism before and after control of thyroid function. | thyroid hormone affects adipocyte function, which in turn influences lipid and carbohydrate metabolism. adiponectin is one of the adipocytokines that regulates lipid and carbohydrate metabolism. the aim of our study was to evaluate circulating levels of adiponectin in patients with thyroid dysfunction before and after normalization of thyroid function with appropriate medication. | 2008 | 18469483 |
| a physical map of the thinopyrum-derived lr19 translocation. | twenty-nine lines with deletions in the lr19 ('indis') translocated chromosome segment were used to physically map three thinopyrum rflp loci as well as the sr25 and sd1 loci. from the data, the relative locations of marker loci on the translocation were determined as: sd1, xpsr165, xpsr105, xps129, lr19, wsp-d1, sr25/y. the data confirmed the reported homoeology between the lr19 segment and chromosome arm 7dl of wheat. also, it seems that the lr19 translocation in 'indis' is very similar to the ... | 1996 | 18469950 |
| genomic diversity and multiple origins of tetraploid (2n = 78, 80) glycine tomentella. | among 15 wild perennial species of the genus glycine willd. subgenus glycine, g. tomentella is exceptional. it is composed of four cytotypes (2n = 38, 40, 78, 80), is diverse in morphological features, and covers a wide geographical area. the objectives of this study were to uncover the genomic diversity in 78- and 80-chromosome cytotypes through a multidisciplinary approach, using cytogenetic, biochemical, and molecular methods, to verify previously identified isozyme groupings and to determine ... | 1994 | 18470090 |
| chronic non-thermal exposure of modulated 2450 mhz microwave radiation alters thyroid hormones and behavior of male rats. | the purpose of this investigation was to analyze the effects of leakage microwave (2450 mhz) irradiation on thyroid hormones and behavior of male rats. | 2008 | 18470749 |
| effects of the synthetic liver x receptor agonist t0901317 on the growth hormone and thyroid hormone axes in male rats. | liver x receptors (lxrs), activated by oxysterols, play an important role in the regulation of lipid and glucose metabolism, which is also markedly dependent on thyroid hormone and growth hormone (gh) status. here, we investigated how a 1-week exposure to the synthetic lxr agonist t0901317 affected gh secretion and thyroid hormone status in male rats. while the pulse frequency of gh secretion was marginally affected there was a highly significant decrease in the triiodo-l-thyronine/thyroxine (t3 ... | 2008 | 18473193 |
| characterization of pseudomonas chlororaphis myovirus 201varphi2-1 via genomic sequencing, mass spectrometry, and electron microscopy. | pseudomonas chlororaphis phage 201varphi2-1 is a relative of pseudomonas aeruginosa myovirus phikz. phage 201 phi2-1 was examined by complete genomic sequencing (316,674 bp), by a comprehensive mass spectrometry survey of its virion proteins and by electron microscopy. seventy-six proteins, of which at least 69 have homologues in phikz, were identified by mass spectrometry. eight proteins, in addition to the major head, tail sheath and tail tube proteins, are abundant in the virion. electron mic ... | 2008 | 18474389 |
| in the italian population sexual dimorphism affects pre-natal thyroid migration but not biochemical severity of gland ectopia and pre-natal bone maturation. | the aim of the present study was to retrospectively re-evaluate a population of selected infants with congenital hypothyroidism (ch), in order to investigate whether sexual dimorphism affects: a) ch etiology; b) its biochemical severity at the time of screening and recall; c) patients' biochemical response to replacement treatment during the 1st yr of life; d) their bone maturation (bm) at birth; e) their psychomotor status at 1 yr. this retrospective study covers 192 infants (116 females) with ... | 2008 | 18475053 |
| effects of a single venous dose of zinc on thyroid status in healthy individuals and patients with graves' disease. | zinc metabolism may regulate thyroid function acting at trh (thyrotropin-releasing hormone) synthesis, peripheral deiodination of t4 (tetraiodothyronine), and binding of thyroid hormones to nuclear receptors. the aim of this study was to investigate the effect of acute zinc administration on tsh (thyroid-stimulating hormone), ft3 (free triiodothyronine), and ft4 (free tetraiodothyronine) in 10 healthy individuals and 12 hyperthyroid patients with graves' disease. all these individuals were studi ... | 2000 | 18475939 |
| [effect of acupuncture--general anesthesia on hemodynamics in perioperative period of patients undergoing cholecystectomy]. | to observe the effect of acupuncture-general anesthesia on hemodynamics in the perioperative period of patients undergoing laparoscopic cholecystectomy. | 2008 | 18476416 |
| [expression and clinical significance of stromelysin-3 in laryngeal cancer]. | to investigate the role of expression of stromelysin-3 in laryngeal carcinoma and the relationship between stromelysin-3 expression and the invasion and metastasis of laryngeal cancer. | 2008 | 18476627 |
| t4 endonuclease v: review and application to dermatology. | t4 endonuclease v was originally isolated from escherichia coli infected with t4 bacteriophage. it has been shown to repair ultraviolet (uv)-induced cyclobutane pyrimidine dimers in dna, which, when unrepaired, contribute to mutations that result in actinic keratoses and non-melanoma skin cancers (nmsc). this is a particular concern in patients with genetic defects in their dna repair systems, especially those with xeroderma pigmentosum (xp). when packaged in liposomes and applied topically, t4 ... | 2008 | 18476794 |
| effects of an oral contraceptive containing 30 mcg ethinyl estradiol and 2 mg dienogest on thyroid hormones and androgen parameters: conventional vs. extended-cycle use. | this study was conducted to investigate the effects of an oral contraceptive containing 30 mcg ethinyl estradiol and 2 mg dienogest on thyroid hormones and androgen parameters. | 2008 | 18477491 |
| filter performance of n99 and n95 facepiece respirators against viruses and ultrafine particles. | the performance of three filtering facepiece respirators (two models of n99 and one n95) challenged with an inert aerosol (nacl) and three virus aerosols (enterobacteriophages ms2 and t4 and bacillus subtilis phage)-all with significant ultrafine components-was examined using a manikin-based protocol with respirators sealed on manikins. three inhalation flow rates, 30, 85, and 150 l min(-1), were tested. the filter penetration and the quality factor were determined. between-respirator and within ... | 2008 | 18477653 |
| [treatment of advanced maxillary sinus squamous carcinoma: an analysis of 92 cases]. | there is no satisfactory treatment for advanced maxillary sinus squamous carcinoma. the treatment strategy is controversial. this study aimed to explore a rational treatment for advanced maxillary sinus squamous carcinoma. | 2008 | 18479606 |
| exercise testing using upper extremity ergometry in pediatric spinal cord injury. | to describe an upper extremity ergometer test for children with spinal cord injury (sci) and examine differences based on injury level for peak heart rate (hr peak), oxygen uptake (vo 2 peak/kg), and peak power output per kilogram (w peak/kg). | 2008 | 18480713 |
| evaluation of brain natriuretic peptide levels in hyperthyroidism and hypothyroidism. | brain natriuretic peptide (bnp) is secreted from the ventricular myocardium in response to volume expansion and pressure overload. serum bnp levels are also affected by thyroid function status, which was mostly related to a direct stimulatory effect of thyroid hormones on the secretion of bnp. although the diagnostic value of bnp in heart failure is undisputed, its value in the presence of the thyroid dysfunction has been recently questioned. the aim of this study was to evaluate the influence o ... | 2008 | 18481478 |
| use of 2-aminopurine fluorescence to study the role of the beta hairpin in the proofreading pathway catalyzed by the phage t4 and rb69 dna polymerases. | for dna polymerases to proofread a misincorporated nucleotide, the terminal 3-4 nucleotides of the primer strand must be separated from the template strand before being bound in the exonuclease active center. genetic and biochemical studies of the bacteriophage t4 dna polymerase revealed that a prominent beta-hairpin structure in the exonuclease domain is needed to efficiently form the strand-separated exonuclease complexes. we present here further mutational analysis of the loop region of the t ... | 2008 | 18481871 |
| mechanisms of orthostatic intolerance following very prolonged exercise. | nine men completed a 24-h exercise trial, with physiological testing sessions before (t1, approximately 0630), during (t2, approximately 1640; t3, approximately 0045; t4, approximately 0630), and 48-h afterwards (t5, approximately 0650). participants cycled and ran/trekked continuously between test sessions. a 24-h sedentary control trial was undertaken in crossover order. within testing sessions, participants lay supine and then stood for 6 min, while heart rate variability (spectral analysis o ... | 2008 | 18483169 |
| association between transillumination breast spectroscopy and quantitative mammographic features of the breast. | transillumination breast spectroscopy (tibs) uses nonionizing optical radiation to gain information about tissue properties directly from the breast. tibs measurements were obtained from 225 women with normal mammograms. principal component analysis was used to reduce the spectral data set into four principal components and to generate four tibs scores (t1-t4) for each woman. these components and scores represent light scattering, water, lipid, and hemoglobin content. percent density, dense area ... | 2008 | 18483324 |
| different co2 levels during incubation interact with hatching time and ascites susceptibility in two broiler lines selected for different growth rate. | embryos from ascites sensitive (as) and resistant lines (ar) were subjected during the third week of incubation to a high co2 (0.4%) (hc) or normal co2 level of 0.2% (nc) in the incubators. the effect on embryonic and hatching parameters and growth, ascites sensitivity and related physiological parameters was followed. at nc conditions ar embryos hatch earlier than as ones but this difference completely disappeared under hc condition, since hatching time of the as line was reduced. moreover, as ... | 1998 | 18484049 |
| metabonomics in cancer diagnosis: mass spectrometry-based profiling of urinary nucleosides from breast cancer patients. | modified nucleosides are formed post-transcriptionally in rna. in cancer disease, the cell turnover and thus rna metabolism is increased, yielding higher concentrations of excreted modified nucleosides. in the presented study, urinary ribonucleosides were used to differentiate between breast cancer patients and healthy volunteers. the nucleosides were extracted from urine samples using affinity chromatography and subsequently analyzed via liquid chromatography ion trap mass spectrometry (lc-it-m ... | 2008 | 18484357 |
| effects of field bean (vicia faba l. var. minor) dietary supplementation on plasma thyroid hormones, insulin, insulin-like growth factor-1 concentrations and mohair characteristics in growing angora goat kids. | twenty-two angora kids were used to study the effect of a dietary supplementation with field bean (vicia faba l. var. minor) on hair follicle activity, mohair characteristics and plasma total thyroxine (t4), triiodothyronine (t3), insulin (ins) and insulin-like growth factor-1 (igf-1) concentrations. at birth, their mothers were divided in two groups (s: supplemented, c: control), the s group being supplemented with 300 g/head/day of whole field bean. at weaning, diet of kids from s group was su ... | 2009 | 18484965 |
| a basic/hydrophobic cleft of the t4 activator mota interacts with the c-terminus of e.coli sigma70 to activate middle gene transcription. | transcriptional activation often employs a direct interaction between an activator and rna polymerase. for activation of its middle genes, bacteriophage t4 appropriates escherichia coli rna polymerase through the action of two phage-encoded proteins, mota and asia. alone, asia inhibits transcription from a large class of host promoters by structurally remodelling region 4 of sigma(70), the primary specificity subunit of e. coli rna polymerase. mota interacts both with sigma(70) region 4 and with ... | 2008 | 18485078 |
| tsh-secreting adenoma improved with cabergoline. | tsh-secreting adenomas are rare tumors, representing only 0.5 to 2.5% of pituitary adenomas. their main clinical characteristics include signs of thyrotoxicosis, diffuse goiter and a compressive syndrome. biologically, free t4 and t3 serum levels are elevated, contrasting with inadequate serum tsh levels and increased alpha chains. magnetic resonance (mr) imaging shows a pituitary tumor, the main differential diagnosis being resistance to thyroid hormones. treatment is based on surgery, possibly ... | 2008 | 18486933 |
| definitive chemoirradiation for resectable head and neck cancer: treatment outcome and prognostic significance of mri findings. | the aim of this study was to evaluate the outcome and prognosticators for patients with resectable head and neck cancer (rhnc) undergoing definitive concurrent chemotherapy and radiotherapy (ccrt). in total, 110 rhnc patients receiving definitive ccrt to defer radical surgery were enrolled. radiotherapy was given as either 2 gy once daily with 70 gy, or 1.2 gy twice daily with 74.4 gy. chemotherapy involved the administration of 5-fluorouracil and cisplatin in two concomitant and two post-radiot ... | 2008 | 18487389 |
| sizing of single globular dna molecules by using a circular acceleration technique with laser trapping. | we describe a method for in situ sizing individual huge dna molecules by laser trapping. single dna molecules are reversibly transformed, without mechanical fragmentation of fragile huge-sized dna, from their random coil state into their globular state induced by condensing agents poly(ethylene glycol) and mg(2+). with the use of a globular dna molecule folded by condensation, the critical velocity of the circularly accelerated single globular dna molecule by laser trapping was found to be propo ... | 2008 | 18489123 |
| induction therapy for poor-prognosis anal canal carcinoma: a phase ii study of the cancer and leukemia group b (calgb 9281). | although most patients with anal canal cancer are cured with sphincter-preserving, nonsurgical, combined-modality therapy, those with large tumors and lymph node involvement have a poor prognosis. to establish the safety and efficacy of induction chemotherapy with infusional fluorouracil (fu) plus cisplatin followed by fu plus mitomycin c with concurrent radiation in patients with poor-prognosis squamous cell cancers of the anal canal. | 2008 | 18490648 |
| association of the ultrasonographic findings of subacute thyroiditis with thyroid pain and laboratory findings. | we aimed to determine whether ultrasonography is a useful diagnostic tool by correlating its findings with biological data of patients with subacute thyroiditis (sat). thirty-two sat patients were evaluated in a retrospective study. thirty-one patients (96.9%) had tenderness, 14 (43.8%) had localized pain, and 11 patients (34.4%) had radiating pain during a state of sat. with ultrasonography, we found 51 hypoechoic areas in 32 patients. the hypoechoic volume per unilateral thyroid gland (%) was ... | 2008 | 18490832 |
| [prognostic factors in head and neck mucoepidermoid carcinoma]. | in patients with mucoepidermoid carcinoma (mec) originating in salivary glands, because of the relative rarity of these tumors and the remarkable variability in their biological behavior, opinions differ about appropriate classification, grading, and treatment. | 2008 | 18492431 |
| graves' disease in brazilian children and adults: lack of genetic association with ctla-4 +49a>g polymorphism. | in several populations, major histocompatibility complex and ctla-4 (cytotoxic t lymphocyte antigen-4) gene polymorphisms are related to adult subjects with graves' disease (gd). our aim was to study the association of +49a>g polymorphism of the ctla-4 gene in brazilian children and adults with gd and its correlation with clinical and laboratory markers of disease severity. | 2008 | 18493148 |
| reversible stenosis of large cerebral arteries in a patient with combined sjögren's syndrome and neuromyelitis optica spectrum disorder. | we report a 49-year-old woman with neuromyelitis optica (nmo) spectrum disorder coexisting with sjögren's syndrome (ss). she presented with acute brainstem symptoms and transverse myelitis. brain mri showed focal high signal intensity lesions in the hypothalamus and the pontine tegmentum on t2-weighted and flair images. mra revealed stenotic changes of the bilateral middle cerebral artery (mca), posterior cerebral arteries (pca) and basilar artery (ba). spinal mri revealed hyperintense lesions w ... | 2008 | 18493764 |
| relationship between serum free t4 (ft4) levels and metabolic syndrome (ms) and its components in healthy euthyroid subjects. | the metabolic syndrome (ms) is associated with increased life-time risk for atherosclerotic cardiovascular disease. while some reports suggest that ms and/or insulin resistance is associated with low serum free t4 (ft4) level in euthyroid subjects, this remains a controversial issue. | 2009 | 18494864 |
| thoracic spinal cord injury without radiographic abnormality in an adult patient. | thoracic spinal cord injury (sci) without fractures or discoligamentary injuries in adults is extremely uncommon. this is because of the inherent stability of the thoracic spine provided by the structure of the ribcage, and the increasing stiffness of the overall spine with rising age. till date, the pathogenesis of this disorder in adults is still unclear. | 2009 | 18495542 |
| rosai-dorfman disease causing spinal cord compression: case report. | rosai-dorfman disease is a rare idiopathic, histiocytic, proliferative disease characterized by massive, painless cervical lymphadenopathy. extranodal involvement is rare and central nervous system involvement is unusual. we present a patient with rosai-dorfman disease with spinal cord compression. very few cases have been reported in the literature. | 2008 | 18496169 |
| thyroid disorders and diabetes mellitus. | diabetes mellitus and thyroid diseases are quite frequently associated. this is true especially when they share the same cause: autoimmune etiology. the hormones involved in this disorders are: insulin, glucagon, thyroxine (t4) and triiodothyronine (t3). all of these affect the carbohydrate metabolism, so that the coexistence of thyroid dysfunction and diabetes may render the glycemic control more difficult to be preserved. | 2008 | 18497724 |
| new application of beta-galactosidase complementation to monitor tau self-association. | neurofibrillary tangles composed of hyperphosphorylated and aberrantly cleaved microtubule-associated protein tau are a major neuropathological hallmark of alzheimer's disease. recent studies suggest that the predominant neurotoxic effect of pathologically processed tau is mediated by intermediate tau multimers rather than the mature tau tangles, thus underscoring the importance of studying tau self-association preceding tangle formation. however, experimental approaches for such studies are lim ... | 2008 | 18498442 |
| pneumonectomy after chemotherapy: morbidity, mortality, and long-term outcome. | results of pneumonectomy after chemotherapy are controversial, and the procedure is often considered as potentially dangerous. | 2008 | 18498785 |
| organic anion transporter 1b1: an important factor in hepatic thyroid hormone and estrogen transport and metabolism. | sulfation is an important pathway in the metabolism of thyroid hormone and estrogens. sulfation of estrogens is reversible by estrogen sulfatase, but sulfation of thyroid hormone accelerates its degradation by the type 1 deiodinase in liver. organic anion transporters (oatps) are capable of transporting iodothyronine sulfates such as t4 sulfate (t4s), t3s, and rt3s or estrogen sulfates like estrone sulfate (e1s), but the major hepatic transporter for these conjugates has not been identified. a p ... | 2008 | 18499754 |
| phytase activity and its regulation in a rhizospheric strain of serratia plymuthica. | serratia plymuthica strain ic1270 isolated from the rhizosphere, possessing antagonistic activity towards a wide range of plant-pathogenic fungi, is able to hydrolyze phytate. phytase activity was found intracellularly, while no activity was detected in the culture liquid. optimum activity was found at ph 4-5; it completely disappeared at ph > 7.0 and 2.5. phytase production was practically absent in the exponential phase and reached a maximum in the late stationary phase. mutations of genes grr ... | 2008 | 18500629 |
| t-dna activation tagging as a tool to isolate salvia miltiorrhiza transgenic lines for higher yields of tanshinones. | the study of functional genomics has paved the way for directed approaches to the generation of genetically modified plants that produce novel and/or improved yields of pharmaceuticals. in the present study, an activation tagging mutagenesis (atm) population of salvia miltiorrhiza bunge, a medicinal plant, was established by agrobacterium-mediated transformation. the optimum conditions for agrobacterium transformation were determined by the expression of green fluorescent protein. under these op ... | 2008 | 18500684 |
| effects of coleus forskohlii supplementation on body composition and hematological profiles in mildly overweight women. | abstract : purpose : this study investigated the effects of coleus forskohlii (cf) on body composition, and determined the safety and efficacy of supplementation. methods : in a double blind and randomized manner, 23 females supplemented their diet with forsleantrade mark (250 mg of 10% cf extract, (n = 7) or a placebo [p] (n = 12) two times per day for 12-wks. body composition (dexa), body weight, and psychometric instruments were obtained at 0, 4, 8 & 12 weeks of supplementation. fasting blood ... | 2005 | 18500958 |
| hypotensive anesthesia with propofol and remifentanil: protective effect of alpha-tocopherol on renal function. | to determine the effect of alpha-tocopherol in patients receiving hypotensive anesthesia with propofol-remifentanil. | 2008 | 18502357 |
| the significance of intrapulmonary metastasis in non-small cell lung cancer: upstaging or downstaging? a re-appraisal for the next tnm staging system. | the management of patients with non-small cell lung cancer (nsclc) with intrapulmonary metastases (pm) is controversial. in tnm classification, pm are designed as t4 when in the same lobe of the primary tumour (pm1) and m1 when in a different lobe(s) (pm2). some authors have questioned the negative prognostic impact of pm. the present study assessed prevalence, correlation with clinico-pathologic variables and impact on survival of pm, along with a review of the literature. | 2008 | 18502660 |
| robot-assisted laparoscopic radical cystoprostatectomy with ileal conduit urinary diversion: initial experience in korea. | in this paper, we report our initial experience of robot-assisted laparoscopic radical cystoprostatectomy (rlrc) with an ileal conduit urinary diversion (icud). our patient was a 59-year-old man presenting with a clinical t4 invasive transitional cell carcinoma of the bladder and prostate. a rlrc was performed with the da vinci() robot system (intuitive surgical, mountain view, ca), which has a total of seven degrees of motion (six degrees of freedom and grip), and endowrist (intuitive surgical) ... | 2008 | 18503374 |
| factors that predict early treatment failure for patients with locally advanced (t4) breast cancer. | locally advanced breast cancer (labc) is associated with dire prognosis despite progress in multimodal treatments. we evaluated several clinical and pathological features of patients with either noninflammatory (nibc, ct4a-c) or inflammatory (ibc, ct4d) breast cancer to identify subset groups of patients with high risk of early treatment failure. clinical and pathological features of 248 patients with labc, who were treated with multimodality treatments including neoadjuvant chemotherapy followe ... | 2008 | 18506176 |
| [prevalence of thyroid autoimmune disease in patients with systemic lupus erythematosus]. | thyroid autoimmune diseases have been associated with a variety of rheumatologic diseases, including systemic lupus erythematosus (sle). | 2008 | 18506279 |
| when does skin excision allow the achievement of an adequate local control rate in patients with squamous cell carcinoma involving the buccal mucosa? | the role of cheek skin excision in patients with squamous cell carcinoma of the buccal mucosa (bscc) remains controversial. we sought to investigate when skin excision is needed to achieve an adequate local control. | 2008 | 18506533 |
| gene therapy for esophageal squamous cell carcinoma. | despite improvement of surgical treatment and application of multi-modality therapies to advanced esophageal cancer, the prognosis is extremely poor in patients with t4 tumors. based on the genetic background of esophageal cancer, we have developed various gene therapy strategies against human esophageal cancer cells. in this article, we reviewed molecular events of esophageal cancer and gene therapy approaches for its treatment. first, we analyzed p53 genetic alterations and angiogenesis in eso ... | 2008 | 18508438 |
| analysis of the factors influencing dysphagia severity upon diagnosis of head and neck cancer. | our aim was to assess the influence of age, co-morbidity factors and tumour characteristics on dysphagia severity in the diagnosis of head and neck cancer. modified barium swallow (mbs) examinations were performed in patients at diagnosis of head and neck cancer. dysphagia was graded on a scale of 1 to 7 of increasing severity. between 2000 and 2006, 236 patients with dysphagia underwent mbs at diagnosis of their head and neck cancer. 82 patients were scored as grade 1, 88 as grade 2, 29 as grad ... | 2008 | 18508871 |
| prognostic value of expression of p53, proliferating cell nuclear antigen, and c-erbb-2 in laryngeal carcinoma. | the molecular mechanisms in malignant transformation of laryngeal mucosa are unknown; many clinical and pathological factors affect prognosis. we investigated a possible correlation between overexpression of p53, proliferating cell nuclear antigen (pcna), and c-erbb-2, and the clinicopathologic features of laryngeal squamous cell carcinoma (scc) and clarify their prognostic value. | 2008 | 18509272 |
| rna silencing-mediated resistance is related to biotic / abiotic stresses and cellular rdrp expression in transgenic tobacco plants. | the discovery of rna silencing inhibition by virus encoded suppressors or low temperature leads to concerns about the stability of transgenic resistance. rna-dependent rna polymerase (rdrp) has been previously characterized to be essential for transgene-mediated rna silencing. here we showed that low temperature led to the inhibition of rna silencing, the loss of viral resistance and the reduced expression of host rdrp homolog (ntrdrp1) in transgenic t4 progeny with untranslatable potato virus y ... | 2008 | 18510868 |
| rna primer handoff in bacteriophage t4 dna replication: the role of single-stranded dna-binding protein and polymerase accessory proteins. | in t4 phage, coordinated leading and lagging strand dna synthesis is carried out by an eight-protein complex termed the replisome. the control of lagging strand dna synthesis depends on a highly dynamic replisome with several proteins entering and leaving during dna replication. here we examine the role of single-stranded binding protein (gp32) in the repetitive cycles of lagging strand synthesis. removal of the protein-interacting domain of gp32 results in a reduction in the number of primers s ... | 2008 | 18511422 |
| the structure of an archaeal homodimeric ligase which has rna circularization activity. | the genome of pyrococcus abyssi contains two open reading frames encoding proteins which had been previously predicted to be dna ligases, pab2002 and pab1020. we show that while the former is indeed a dna ligase, pab1020 had no effect on the substrate deoxyoligo-ribonucleotides tested. instead, pab1020 catalyzes the nucleotidylation of oligo-ribonucleotides in an atp-dependent reaction, suggesting that it is an rna ligase. we have solved the structure of pab1020 in complex with the atp analog am ... | 2008 | 18511537 |
| plasticity of lumbosacral propriospinal neurons is associated with the development of autonomic dysreflexia after thoracic spinal cord transection. | complete thoracic (t) spinal cord injury (sci) above the t6 level typically results in autonomic dysreflexia, an abnormal hypertensive condition commonly triggered by nociceptive stimuli below the level of sci. overexpression of nerve growth factor in the lumbosacral spinal cord induces profuse sprouting of nociceptive pelvic visceral afferent fibers that correlates with increased hypertension in response to noxious colorectal distension. after complete t4 sci, we evaluated the plasticity of pro ... | 2008 | 18512692 |
| a new combination of rna-mediated dna ligation and on-chip elongation for detecting viral rna. | we describe a novel method that combines rna-mediated dna ligation and on-chip elongation for detecting viral rna. these virus species-specific detection probes (dps) were designed to match sequences of the "target" virus and then chemically synthesized into 2 parts. if the target virus exists, 2 parts of the dp can be ligated by t4 dna ligase. the ligated dp was hybridized to its corresponding capture probe (cp) on a dna array. then, an on-chip dna polymerization (including cy3-dutp) was perfor ... | 2008 | 18513911 |
| comparison of an equal-dose spinal anesthetic for cesarean section and for post partum tubal ligation. | we postulated that a spinal dose of hyperbaric bupivacaine 12 mg and morphine 100 microg administered for cesarean section would yield an equivalent sensory block height and provide sufficient analgesia if administered within 48 h of delivery for postpartum tubal ligation. | 2008 | 18513944 |
| phosphodiesterase 8b gene variants are associated with serum tsh levels and thyroid function. | thyroid-stimulating hormone (tsh) controls thyroid growth and hormone secretion through binding to its g protein-coupled receptor (tshr) and production of cyclic amp (camp). serum tsh is a sensitive indicator of thyroid function, and overt abnormalities in thyroid function lead to common endocrine disorders affecting approximately 10% of individuals over a life span. by genotyping 362,129 snps in 4,300 sardinians, we identified a strong association (p = 1.3 x 10(-11)) between alleles of rs470439 ... | 2008 | 18514160 |
| [conjunctival bacterial flora after topical use of ciprofloxacin and gatifloxacin in cataract surgery]. | to evaluate alterations of the conjunctival flora after the use of 0.3% ciprofloxacin and gatifloxacin in the prophylaxis of patients undergoing cataract surgery. | 2008 | 18516418 |
| laminin expression in advanced laryngeal squamous cell carcinoma does not correlate to neck metastases. | laminins are a family of glycoproteins that consist of one heavy alpha chain and two light beta and gamma chains. the laminin molecule is a major component of the basement membrane and plays an important roles in cell differentiation, adhesion, and migration. it has been reported that laminin is strongly expressed at the invasive front of the tumor and plays an important role in forming the metastases. the aim of the study was to assess the importance of laminin expression in a group of patients ... | 2008 | 18516614 |
| the new generation of family physicians--career motivation, life goals and work-life balance. | the present study aimed to investigate the differences between future family physicians, and physicians aspiring to other medical specialities, in terms of sociodemographic factors and variables concerning personality factors, career motivation, career success, importance of life goals and work-life balance; further, the stability in career choice of family physicians from medical school through to residency was evaluated. | 2008 | 18516751 |
| [cesarean section in a morbidly obese parturient with borderline personality disorder under combined spinal and epidural anesthesia]. | a 21-year-old morbidly obese parturient with a body mass index of 45.5 kg x m(-2) underwent an emergent cesarean section for obstructed labor under combined spinal and epidural anesthesia. at age 15, she was diagnosed as borderline personality disorder. in spite of the drug therapy, her mental status was unstable. during anesthesia and surgery, her psychiatrist attended beside her to ease her anxiety and mental stress. an experienced anesthesiologist encouraged her and maintained her in the sitt ... | 2008 | 18516893 |
| beta1 integrin inhibition dramatically enhances radiotherapy efficacy in human breast cancer xenografts. | beta(1) integrin signaling has been shown to mediate cellular resistance to apoptosis after exposure to ionizing radiation (ir). other signaling molecules that increase resistance include akt, which promotes cell survival downstream of beta(1) integrin signaling. we previously showed that beta(1) integrin inhibitory antibodies (e.g., aiib2) enhance apoptosis and decrease growth in human breast cancer cells in three-dimensional laminin-rich extracellular matrix (lrecm) cultures and in vivo. here, ... | 2008 | 18519702 |
| squamous cell carcinoma of the temporal bone: results and management. | evaluation of the management and survival of patients treated for temporal bone squamous cell carcinoma. | 2008 | 18520589 |
| nasopharyngeal carcinoma with orbital involvement. | to describe the clinical presentation of patients with nasopharyngeal carcinoma and orbital involvement. | 2008 | 18520832 |
| elective bilateral above the knee amputation in t4-complete spinal cord injury: a case report. | this case study outlines an individual with a t4 complete level injury with ashworth scale grade 4 spasticity of the lower extremities. | 2008 | 18521093 |
| effect of thyroid hormones on the stage-specific pigmentation of the japanese flounder paralichthys olivaceus. | three experiments were carried out to clarify the effect of thyroid hormones on the pigmentation of larval japanese flounder paralichthys olivaceus. the first two experiments were conducted to investigate the critical concentration of thyroxine (t4) which causes abnormal pigmentation, and the third was to determine the sensitive stage of larval development at which albinism is induced by exogenous t4. the larvae treated with over 10 nm t4 showed a significant increase of albinism in experiments ... | 2000 | 18522465 |
| [treatment of palmar and axillary hyperhidrosis: thoracoscopic resection of the sympathetic chain]. | thoracic sympathectomy is a valuable treatment option for patients with primary hyperhidrosis. however, controversies exist about the optimal technique of sympathectomy and the association between localisation of the focal hyperhidrosis and postoperative results. | 2008 | 18523743 |
| the effects of low thyroid hormone levels on the formation of stress gastritis: an experimental study on the rats. | the aim of this study was to investigate the effect of low circulating thyroid hormone levels on the development of acute stress gastritis in rats. | 2008 | 18523899 |
| stability indicating validated hplc method for quantification of levothyroxine with eight degradation peaks in the presence of excipients. | a simple, sensitive, accurate, and robust stability indicating analytical method is presented for identification, separation, and quantitation of l-thyroxine and eight degradation impurities with an internal standard. the method was used in the presence of commonly used formulation excipients such as butylated hydroxyanisole, povidone, crospovidone, croscarmellose sodium, mannitol, sucrose, acacia, lactose monohydrate, confectionary sugar, microcrystalline cellulose, sodium laurel sulfate, magne ... | 2008 | 18524511 |
| a proteomic approach to the identification of the major virion structural proteins of the marine cyanomyovirus s-pm2. | in this study, an ms-based proteomics approach to characterizing the virion structural proteins of the novel marine 'photosynthetic' phage s-pm2 is presented. the virus infects ecologically important cyanobacteria of the genus synechococcus that make a substantial contribution to primary production in the oceans. the s-pm2 genome encodes 236 orfs, some of which exhibit similarity to known phage virion structural proteins, but the majority (54%) show no detectable homology to known proteins from ... | 2008 | 18524932 |
| attenuation of lower-thoracic, lumbar, and sacral spinal cord motion: implications for imaging human spinal cord structure and function. | recent literature indicates that cervical and upper-thoracic spinal cord motion adversely affect both structural and functional mr imaging (fmri; particularly diffusion tensor imaging [dti] and spinal fmri), ultimately reducing the reliability of these methods for both research and clinical applications. in the present study, we investigated motion of the lower-thoracic, lumbar, and sacral cord segments to evaluate the incidence of similar motion-related confounds in these regions. | 2008 | 18524976 |
| thyroid function, alzheimer's disease and postoperative cognitive dysfunction: a tale of dangerous liaisons? | hypothyroidism and hyperthyroidism are commonly present conditions in adults, leading to neurological symptoms, affecting the central and peripheral nervous system, and to neurocognitive impairment. several studies investigated a possible association between alzheimer's disease (ad) and thyroid dysfunctions. increasing evidence supports an extensive interrelationship between thyroid hormones and the cholinergic system, which is selectively and early affected in ad. moreover, thyroid hormones neg ... | 2008 | 18525131 |
| treatment of base of tongue cancer with paclitaxel, ifosfamide, and cisplatinum induction chemotherapy followed by chemoradiotherapy. | to assess the efficacy of paclitaxel, ifosfamide, and cisplatinum induction chemotherapy plus concurrent chemoradiation in the treatment of stage iii and iv base of tongue cancer. | 2008 | 18528311 |
| value of bronchoscopy after eus in the preoperative assessment of patients with esophageal cancer at or above the carina. | esophageal cancer is an aggressive disease with a strong tendency to infiltrate into surrounding structures. the aim of the present study is to determine the additional value of bronchoscopy for detecting invasion of the tracheobronchial tree after endoscopic ultrasonography (eus) in the preoperative assessment of patients with esophageal cancer at or above the carina. | 2008 | 18528732 |
| plasma thyroxine and cortisol profiles and gill and kidney na+/k+-atpase and sdh activities during acclimation of the catfish heteropneustes fossilis (bloch) to higher salinity, with special reference to the effects of exogenous cortisol on hypo-osmoregulatory ability of the catfish. | when the stenohaline catfish heteropneustes fossilis was transferred from fresh water (fw) to 30% seawater (sw), the na(+)/k(+)-atpase activity significantly increased in the kidney, while in gills it remained more or less constant. a reverse pattern was observed for succinic dehydrogenase (sdh) activity inasmuch as it significantly increased in gills and remained unchanged in the kidney. plasma osmolality significantly increased within 3 days of transfer to 30% sw and remained significantly hig ... | 2008 | 18533747 |