| validation of the proposed international association for the study of lung cancer non-small cell lung cancer staging system revisions for advanced bronchioloalveolar carcinoma using data from the california cancer registry. | recently, the international association for the study of lung cancer (iaslc) has proposed significant modifications to the existing tnm and stage grouping classifications affecting the t4 and m descriptors. we set out to validate this staging system for bronchioloalveolar carcinoma (bac) cases using data from the california cancer registry (ccr). | 2007 | 18090578 |
| a retrospective study of definitive chemoradiotherapy for elderly patients with esophageal cancer. | the efficacy and safety of definitive chemoradiotherapy (crt) for elderly patients with esophageal cancer have not been fully elucidated yet. we conducted a retrospective comparison of the outcomes of crt between elderly and nonelderly patients with stage ii-iii (non-t4) esophageal cancer. | 2007 | 18091055 |
| radiotherapy for squamous cell carcinoma of the nasal vestibule. | to evaluate the efficacy of radiotherapy (rt) alone or combined with surgery for the treatment of the nasal vestibule squamous cell carcinomas. | 2007 | 18091056 |
| measuring tissue perfusion during pressure relief maneuvers: insights into preventing pressure ulcers. | to study the effect on tissue perfusion of relieving interface pressure using standard wheelchair pushups compared with a mechanical automated dynamic pressure relief system. | 2007 | 18092567 |
| competitive immunoassays for simultaneous detection of metabolites and proteins using micromosaic patterning. | new high-throughput immunoassay methods for rapid point-of-care diagnostic applications represent an unmet need and current focus of numerous innovative methods. we report a new micromosaic competitive immunoassay developed for the analysis of the thyroid hormone thyroxine (t4), inflammation biomarker c-reactive protein (crp), and the oxidative damage marker 3-nitrotyrosine (bsa-3nt) on a silicon nitride substrate. to demonstrate the versatility of the method, both direct and indirect format com ... | 2008 | 18092765 |
| the duisburg birth cohort study: influence of the prenatal exposure to pcdd/fs and dioxin-like pcbs on thyroid hormone status in newborns and neurodevelopment of infants until the age of 24 months. | prenatal exposure to polychlorinated biphenyls (pcbs) and polychlorinated dibenzo-p-dioxins and dibenzofurans (pcdd/fs) can affect neurobehavioral development of infants and children. this effect may be mediated through disruption of thyroid hormone homeostasis. however, epidemiological studies reveal no consistent influence of pcdd/fs and pcbs on thyroid status and neurodevelopment at environmental background levels. the effects may resolve with time of further decreasing exposure to these comp ... | 2008 | 18093869 |
| accuracy of preoperative t-staging of gallbladder carcinoma using mdct. | the objective of our study was to evaluate the performance of mdct in the preoperative t-staging of gallbladder cancer and to determine whether adding multiplanar reconstruction (mpr) images to axial images can improve the accuracy of mdct for the t-staging of gallbladder cancer. | 2008 | 18094296 |
| prognostic impact of perineural invasion following pancreatoduodenectomy with lymphadenectomy for ampullary carcinoma. | the aim of this study was to identify prognostic factors in patients undergoing pancreatoduodenectomy with lymphadenectomy for ampullary carcinoma. the records of 46 consecutive patients with ampullary carcinoma who underwent pancreatoduodenectomy from 1988 through 2006 were retrospectively reviewed. a 98% rate of potentially curative (r0) resection was achieved. there was no 30-day mortality. overall 5-year survival rate was 64%. univariate analysis revealed that t3 and t4 tumor (i.e., pancreat ... | 2008 | 18095164 |
| structural determinants of nitroxide motion in spin-labeled proteins: solvent-exposed sites in helix b of t4 lysozyme. | site-directed spin labeling provides a means for exploring structure and dynamics in proteins. to interpret the complex epr spectra that often arise, it is necessary to characterize the rotamers of the spin-labeled side chain and the interactions they make with the local environment in proteins of known structure. for this purpose, crystal structures have been determined for t4 lysozyme bearing a nitroxide side chain (r1) at the solvent-exposed helical sites 41 and 44 in the b helix. these sites ... | 2008 | 18096642 |
| tumor pathology and long-term survival in emergency colorectal cancer. | patients who have an emergency operation for colorectal cancer have poorer long-term survival outcomes compared with elective patients. this study was designed to define the role of tumor pathology as a basis for the differences in survival outcomes. | 2008 | 18097722 |
| identification of host range mutants of myxoma virus with altered oncolytic potential in human glioma cells. | the authors have recently demonstrated that wild-type myxoma virus (mv) tagged with gfp (vmyxgfp) can generate a tumor-specific infection that productively infects and clears human tumor-derived xenografts when injected intratumorally into human gliomas transplanted into immunodeficient mice (lun et al, 2005). to expand the understanding of mv tropism in cancer cells from a specific tissue lineage, the authors have screened a series of human glioma cells (u87, u118, u251, u343, u373) for myxoma ... | 2007 | 18097886 |
| resected synchronous primary malignant lung tumors: a population-based study. | synchronous lung tumors with a histology indicating primary lung carcinomas detected preoperatively or at surgery may represent intrapulmonary metastases from a primary tumor or two or more simultaneously occurring primary tumors. the situation is rare. this study was conducted to assess the characteristics and outcome for this patient group. | 2008 | 18154811 |
| is fledging in king penguin chicks related to changes in metabolic or endocrinal status? | this study examines the possibility that metabolic or endocrinal factors initiate fledging in the king penguin, a semi-altricial seabird species breeding a single chick on the ground. chick fledging (departure to sea) occurred 5d after completion of the molt. it was preceded by a 16d fasting period and by a 7-fold increase in locomotor activity. from the measurement of the plasma concentration of metabolites and of glucagon and insulin, pre-fledging king penguin chicks were found to adapt to fas ... | 2008 | 18155218 |
| localised malignant pleural mesothelioma: a separate clinical entity requiring aggressive local surgery. | localised malignant pleural mesotheliomas are very rare and although there are sporadic reports in the literature showing that they have a different biological behaviour compared to diffuse mpm there is no major series published demonstrating results of surgical treatment. we present our experience in treating these tumours. | 2008 | 18155556 |
| have surgical outcomes of pathologic t4 esophageal squamous cell carcinoma really improved? analysis of 268 cases during 45 years of experience. | because invasion to an adjacent organ (t4) indicates highly advanced disease, and most surgeons avoid esophagectomy, the prognostic impact of clinicopathologic factors for survival of these patients after esophagectomy has rarely been analyzed. | 2008 | 18155568 |
| treatment of patients with unresectable squamous head and neck cancer with induction chemotherapy followed by hyperfractionated radiotherapy. | the contribution of induction chemotherapy (ct) followed by hyperfractionated radiotherapy (hfrt) in unresectable squamous head and neck cancer has been evaluated in a single institution as an assistencial protocol. | 2008 | 18155633 |
| [treatment of rectal cancer by laparoscopie]. | initiated later than for colon cancer, the evaluation of the use of laparoscopy in rectal cancer is still ongoing. data on its feasibility and clinical tolerance are available. evaluation has been based on better vision of total mesorectal excision down to the pelvic floor with laparoscopy. laparoscopy may be recommended as standard practice except in the case of t4 tumours, recurrences and after certain former colorectal procedures. the conversion rate decreases with the acquisition of experien ... | 2007 | 18156113 |
| [bone mineral density of children and adolescents with congenital hypothyroidism]. | a cross sectional study was made on 60 patients (9.9 +/- 1.8 yr-old) with congenital hypothyroidism (ch) (group a): 40 girls (23 prepubertal) and 20 boys (18 prepubertal). control group (group b) was constituted of 28 healthy children (10.4 +/- 2.1 yr-old): 18 girls (8 prepubertal) and 10 boys (9 prepubertal). aims: to evaluate bone mineral density (bmd) and content (bmc) and to correlate them with chronological and bone age (ba), sex, sexual maturation, l-t4 dose, tsh, tt4, ft4, and ch etiology ... | 2007 | 18157383 |
| primary malignant melanoma of the female urethra. | a case of primary urethral malignant melanoma of a 69-year-old japanese woman is presented. a hemorrhagic tumor measuring 1 cm in diameter was diagnosed by the stamp method. clinically, the primary lesion was a t4 tumor infiltrating to the bladder neck, vagina, and vulva. computed tomography did not detect any inguinal lymph node swelling or metastases to other sites. we selected radical extirpation, including cystectomy, ureterostomy, and bilateral inguinal and pelvic lymph node dissection. alt ... | 2007 | 18158055 |
| role of fdg-pet in the assessment of survival prognosis in melanoma. | positron-emission tomography (pet) employing fluorodeoxyglucose (fdg) has proven to be a highly sensitive and specific diagnostic method in the staging and restaging of various neoplasms, including melanoma, complementing morphologic imaging. fdg uptake has been correlated with proliferation rate, and thus, the degree of malignancy of a given tumor (i.e., grading). consecutively, a relationship of survival prognosis and the extent of tumor burden as well as degree of fdg accumulation--determined ... | 2007 | 18158764 |
| new insight into the recognition of branched dna structure by junction-resolving enzymes. | junction-resolving enzymes are nucleases that exhibit structural selectivity for the four-way (holliday) junction in dna. in general, these enzymes both recognize and distort the structure of the junction. new insight into the molecular recognition processes has been provided by two recent co-crystal structures of resolving enzymes bound to four-way dna junctions in highly contrasting ways. t4 endonuclease vii binds the junction in an open conformation to an approximately flat binding surface wh ... | 2008 | 18160275 |
| analysis of actinomycin d treated cattle oocytes and their use for somatic cell nuclear transfer. | the present work aimed to evaluate the transcription and replication inhibitor, actinomycin d, for oocyte chemical enucleation. cattle oocytes matured in vitro were treated with actinomycin d according to the following treatments: t1, control; t2=1.0 microg/ml for 16 h; t3=1.0 microg/ml for 14 h; t4=2.5 microg/ml for 14 h; t5=5.0 microg/ml for 14 h. the oocytes were denuded and activated during 24-26 h of maturation. oocytes were fixed to determine the maturation status and for chromosome morpho ... | 2008 | 18162337 |
| subpial hemangiopericytoma with marked extramedullary growth: case report. | hemangiopericytomas, vascular tumors arising in soft tissue, are relatively rare in the central nervous system; they comprise less than 1% of all hemangiopericytomas. central nervous system hemangiopericytomas occur primarily in the epidural space of the brain and spinal cord. there are no previous reports of subpial, extramedullary growing central nervous system hemangiopericytomas. | 2007 | 18162866 |
| the effects of simvastatin and levothyroxine on intima-media thickness of the carotid artery in female normolipemic patients with subclinical hypothyroidism: a prospective, randomized-controlled study. | patients with subclinical hypothyroidism (sht) have an increased risk of developing atherosclerosis, probably related to dyslipidemia. we compared the effects of levothyroxine (l-t4) versus simvastatin treatment on carotid intima-media thickness (imt) and lipid profiles in patients with sht. | 2007 | 18163011 |
| prognostic significance of depth of invasion, vascular invasion and numbers of lymph node retrievals in combination for patients with stage ii colorectal cancer undergoing radical resection. | to determine which aspects of tumor histology influenced the postoperative relapse and overall survival rates after radical resection of uicc stage ii colorectal cancer (crc). | 2008 | 18163435 |
| vertebral body growth after craniospinal irradiation. | to estimate the effects of radiotherapy and clinical factors on vertebral growth in patients with medulloblastoma and supratentorial primitive neuroectodermal tumors treated with craniospinal irradiation (csi) and chemotherapy. | 2008 | 18164830 |
| excellent local control with stereotactic radiotherapy boost after external beam radiotherapy in patients with nasopharyngeal carcinoma. | to determine long-term outcomes in patients receiving stereotactic radiotherapy (srt) as a boost after external beam radiotherapy (ebrt) for locally advanced nasopharyngeal carcinoma (npc). | 2008 | 18164839 |
| phase i-ii trial of concurrent capecitabine and oxaliplatin with preoperative intensity-modulated radiotherapy in patients with locally advanced rectal cancer. | to identify the maximal tolerated dose level of preoperative intensity-modulated radiotherapy combined with capecitabine and oxaliplatin and to evaluate the efficacy. | 2008 | 18164861 |
| implementation of a t4 extraction control for molecular assays of cerebrospinal fluid and stool specimens. | the use of appropriate extraction and amplification controls for acellular specimens is not standardized in the clinical laboratory community. extraction controls and checks for inhibitors of amplification in cellular specimens are most often accomplished by amplification of an internal human genomic target. this approach is not feasible for acellular specimens, which may contain little or no amplifiable genomic material. other specimen types, such as stool, frequently contain amplification inhi ... | 2008 | 18165271 |
| the therapeutic potential of intraoperative hypercapnia during video-assisted thoracoscopy in pediatric patients. | although the cardiovascular effect of co2 insufflation has not been reported in pediatric thoracoscopy, several clinical trials have demonstrated significant hemodynamic deterioration in adults. we investigated the concept of therapeutic hypercapnia for counteracting the hemodynamic effect of induced capnothorax. | 2008 | 18165558 |
| bacteriophages support anti-tumor response initiated by dc-based vaccine against murine transplantable colon carcinoma. | bacteriophages in eukaryotic hosts may behave as particulate antigens able to activate the innate immune system and generate adaptive immunity. dendritic cells (dcs) play a key role in the initiation of the immune response, mainly by priming t cell-mediated immunity. for this reason, they are increasingly applied as an adjuvant for effective anti-tumor therapies in animal models as well as in a few clinical trials. the presented study focused on the application of mouse dcs which were activated ... | 2008 | 18166233 |
| post-thyroidectomy thyroxine replacement dose in patients with or without compensated heart failure: the role of cytokines. | to investigate the potential association between serum inflammatory cytokine levels and post-thyroidectomy thyroxine replacement dose in patients with or without compensated heart failure. | 2008 | 18166485 |
| tsh-receptor autoimmunity in graves' disease after therapy with anti-thyroid drugs, surgery, or radioiodine: a 5-year prospective randomized study. | autoimmunity against the tsh receptor is a key pathogenic element in graves' disease. the autoimmune aberration may be modified by therapy of the hyperthyroidism. | 2008 | 18166819 |
| changes in heart rate variability and qt dispersion in patients with overt hypothyroidism. | the aim of the present study was to evaluate the effect of clinical hypothyroidism on cardiovascular autonomic function and ventricular repolarization. | 2008 | 18166821 |
| lymph node metastases of adenocarcinoma of the esophagus and esophagogastric junction. | esophageal adenocarcinoma is becoming an increasingly important problem. it has been the most rapidly increasing malignancy in western countries in the last decades, and its prognosis is poor. the aim of this study was to evaluate the relationship between tumor invasion depth and lymph node metastasis for adenocarcinoma of the esophagus and esophagogastric junction, and to analyze the impact of lymph node metastases on survival of the patients. | 2007 | 18167216 |
| pediatric thyroid testing issues. | thyroid problems are common in children. while serum thyroid function tests lead to an accurate diagnosis in most patients, unique patient situations can produce misleading results. total t4 measurements can incorrectly suggest hypothyroidism in congenital thyroid binding globulin (tbg) deficiency and hyperthyroidism in tbg excess, as seen in high estrogen states. free t4 (ft4) measurement techniques involve either physical separation of unbound thyroxine from serum binding proteins or estimatio ... | 2007 | 18167471 |
| on the origin of the polar order of t4 lysozyme on planar model surfaces. | site directed spin labeling is used to investigate the origin of the macroscopic alignment of t4 lysozyme vectorially tethered to planar biomimetic surfaces. t4 lysozyme was adsorbed to a quartz-supported dioleoylphosphatidylcholine (dopc) bilayer by selective binding of the histidine-tagged protein to functionalized headgroups (1,2-dioleoyl-sn-glycero-3-[[n(5-amino-1-carboxypentyl)iminodiacetic acid]succinyl], dogs nta) of the bilayer. this results in a polar oriented ensemble of proteins on th ... | 2008 | 18171040 |
| thyroxine increases the rate but does not alter the pattern of innervation during embryonic chick corneal development. | embryonic chick corneal nerves reach limbal mesenchyme by embryonic day (e)5, encircle the cornea in several days, then defasciculate into the stroma simultaneously from all sides, while extracellular keratan sulfate proteoglycan (kspg) accumulates from posterior to anterior stroma. precocious thyroxine (t4)-induced increases in corneal thinning/transparency are blocked by 2-thiouracil (2-tu) inhibition of t3 synthesis. the hypothesis for this study was that precocious t4 exposure increases corn ... | 2008 | 18172086 |
| a novel fusion gene, trim5-cyclophilin a in the pig-tailed macaque determines its susceptibility to hiv-1 infection. | in old world monkeys, the tripartite motif 5alpha (trim5alpha) protein confers resistance to hiv-1 infection following virus entry into host cells. however, the pig-tailed macaque (macaca nemestrina) is an exception and is susceptible to hiv-1 infection. this study dissects the molecular mechanism of the pig-tailed macaque's susceptibility to hiv-1 infection. | 2007 | 18172386 |
| endovascular exclusion of mycotic aortic aneurysm. | the presence of prohibitive risk may preclude usual surgical management. such was the case for a critically ill, 60-year-old woman who presented with concomitant, life-threatening conditions. the patient presented with acute central cord syndrome and lower-extremity paraplegia after completing a 6-week course of intravenous antibiotics for methicillin-sensitive staphylococcus aureus bacteremia and osteomyelitis of the thoracic spine. radiologic examination revealed bony destruction of thoracic v ... | 2007 | 18172531 |
| changes in oral health-related quality of life during fixed orthodontic appliance therapy. | our objective was to determine changes in oral health-related quality of life (ohrqol) during fixed orthodontic appliance therapy. | 2008 | 18174067 |
| tsh alone is not sufficient to exclude all patients with a functioning thyroid nodule from undergoing testing to exclude thyroid cancer. | the purpose of the study was to analyze whether the thyroid-stimulating hormone (tsh) alone avoids tests to exclude malignancy in all patients with functional thyroid nodules (ftn). | 2008 | 18175114 |
| the diagnostic value of 124i-pet in patients with differentiated thyroid cancer. | the purpose of this prospective study was to evaluate the clinical diagnostic value of iodine-124 (124i)-positron emission tomography (pet) in patients with advanced differentiated thyroid carcinoma (dtc) and to compare the 124i-pet imaging results with the 131i whole-body scan (wbs). | 2008 | 18175115 |
| a family with a novel tsh receptor activating germline mutation (p.ala485val). | autosomal dominant nonautoimmune hyperthyroidism (adnah) is caused by gain of function mutations in the tsh receptor (tshr) gene and characterized by toxic thyroid hyperplasia with a variable age of onset in the absence of thyroid antibodies and clinical symptoms of autoimmune thyroid disease in at least two generations. we report here a turkish family with a novel tshr gene mutation with distinct features all consistent with adnah. thyroid function tests of the proband were as follows: free t3: ... | 2008 | 18175146 |
| adenocarcinoma of ethmoid: a gettec retrospective multicenter study of 418 cases. | to determine risk factors and evaluate the treatment of ethmoid adenocarcinoma. epidemiologic data were recorded and compared with the literature. | 2008 | 18176354 |
| comparison of the clinical and pathological features between patients with recurrent metastatic breast carcinoma and patients with initially metastatic breast carcinoma. | to compare initial metastatic breast carcinoma (mbc) with recurrent mbc and assess their biologic phenotypes and clinical behaviors. | 2008 | 18176678 |
| serum tsh and total t4 in the united states population and their association with participant characteristics: national health and nutrition examination survey (nhanes 1999-2002). | describe thyrotropin (tsh) and thyroxine (t4) levels in the u.s. population and their association with selected participant characteristics. | 2007 | 18177256 |
| measurement of cd4+ t cells in point-of-care settings with the sysmex poch-100i haematological analyser. | the decision to provide antiretroviral therapy to hiv-positive patients mainly depends on the cd4(+) t-cell count, with therapy indicated at a cut-off value of <350-200 cd4(+) t cells/microl blood. monitoring patients is still a major problem in countries with limited resources where blood samples often have to be transported over long distances to regional referral centres in which the count can be performed on flow cytometers. we have evaluated a newly developed simple and inexpensive method f ... | 2009 | 18177434 |
| effectiveness of x-ray and computed tomography screening for assessing pulmonary involvement in patients with head and neck squamous cell carcinoma. | to evaluate the benefits of chest computed tomography and x-ray as screening tools in patients with newly diagnosed head and neck squamous cell carcinoma, to determine the incidence of lung metastases or synchronous pulmonary lesions, and to evaluate factors associated with positive radiological findings. | 2008 | 18177532 |
| squamous cell carcinoma of the temporal bone. | the aim of this study was to present the management and survival data of patients with squamous cell carcinoma of the temporal bone, and to discuss whether extensive surgery improves survival. | 2008 | 18177533 |
| 1-deoxyrubralactone, a novel specific inhibitor of families x and y of eukaryotic dna polymerases from a fungal strain derived from sea algae. | talaroflavone (1) and 1-deoxyrubralactone (2) are natural compounds isolated from cultures of a fungal strain derived from sea algae, and their structures were determined by spectroscopic analyses. compound 2 is a novel rubralactone derivative, 6-hydroxy-8-methoxy-1-methyl-1,2,3a,9b-tetrahydrocyclopenta[c]isochromene-3,5-dione. these compounds selectively inhibited the activities of families x and y of eukaryotic dna polymerases (pols), and compound 2 was a stronger inhibitor than compound 1. th ... | 2008 | 18178092 |
| serotypes a1 and a2 of mannheimia haemolytica are susceptible to genotypic, capsular and phenotypic variations in contrast to t3 and t4 serotypes of bibersteinia (pasteurella) trehalosi. | mannheimia haemolytica and bibersteinia (pasteurella) trehalosi are the most common bacterial isolates that cause pulmonary diseases in ruminants worldwide. the disease is determined by specific serotypes found in cattle and small ruminants. the molecular epidemiology of strains involved in disease is important in the control of outbreaks as well as in the preparation of vaccines. this study aimed to detect the instability and variations of bacterial strains that may affect the analysis of epide ... | 2008 | 18179587 |
| clinical effects of leukofiltration and surface modification on post-cardiopulmonary bypass atrial fibrillation in different risk cohorts. | a manifestation of inflammatory injury to the heart, atrial fibrillation (af), ranks among the most frequent and potentially life-threatening post-operative complications. | 2007 | 18181517 |
| thyrotropin serum concentrations in healthy volunteers are associated with depression-related personality traits. | alterations of the hypothalamic-pituitary-thyroid system at the hypophyseal level have been described in affective disorders. the neo five-factor inventory is a widely used instrument, which assesses neuroticism, a strong marker for vulnerability to depression. | 2008 | 18182832 |
| controlling the reactivity of adsorbed dna on template surfaces. | the ability to place dna on surfaces with increased and controllable reactivity is of fundamental importance in the development of next-generation dna and protein biochips. the present work demonstrates the ability to control both the localization of the dna on a surface and its reactivity by a self-assembly approach that is dependent on two variables: dna structure and surface environment. here we utilize a two-step adsorption scheme to control the adsorption and reactivity of dna embedded with ... | 2008 | 18184019 |
| conversion rate in 300 laparoscopic rectal resections and its influence on morbidity and oncological outcome. | the negative influence of conversion from laparoscopic to open colorectal resection on early postoperative morbidity and outcome has been demonstrated several times. in this study, we analyzed the conversion rate and its influence on early postoperative morbidity and short-term oncological outcome following laparoscopic rectal resections. | 2008 | 18185938 |
| effect of selenium and copper supplementation on blood metabolic profile in male buffalo (bubalus bubalis) calves. | twenty male buffalo calves (8-9 months, 112.1 +/- 7.69 kg) were divided into four groups of five animals in each and fed diets without (t1) or supplemented with 0.3 ppm selenium (se) (t2), 0.3 ppm se + 10 ppm copper (cu) (t3), and 10 ppm cu (t4) for 120 days during which blood samples were collected on day 0, 40, 80, and 120. concentrations of glucose, total protein, urea, uric acid, and creatinine were similar in all the four groups, but the level of globulin was significantly (p < 0.01) increa ... | 2008 | 18185997 |
| the use of konjac glucomannan to lower serum thyroid hormones in hyperthyroidism. | patients with hyperthyroidism occasionally need rapid restoration to the euthyroid state. in view of the increased enterohepatic circulation of thyroxine (t4) and triiodothyronine (t3) in thyrotoxicosis, and metabolic effects of konjac glucomannan in gastrointestinal system, we aimed to determine the activity of glucomannan in treatment of hyperthyroidism. | 2007 | 18187431 |
| t-even-related bacteriophages as candidates for treatment of escherichia coli urinary tract infections. | multidrug-resistant uropathogenic escherichia coli (upec) is increasing gradually on a worldwide scale. we therefore examined the possibility of bacteriophage (phage) therapy for urinary tract infections (utis) caused by the upec strains as an alternative to chemotherapy. in addition to the well-known t4 phage, kep10, which was newly isolated, was used as a therapeutic phage candidate. kep10 showed a broader bacteriolytic spectrum (67%) for upec strains than t4 (14%). morphological and genetic a ... | 2008 | 18188500 |
| esophageal cancer. a prospective phase ii study of concomitant-boost external-beam chemoradiation with a top-up endoluminal boost. | to present the results of a prospective phase ii study in esophageal carcinoma. | 2008 | 18188518 |
| assessment of stroke volume index with three different bioimpedance algorithms: lack of agreement compared to thermodilution. | the accuracy of bioimpedance stroke volume index (svi) is questionable as studies report inconsistent results. it remains unclear whether the algorithms alone are responsible for these findings. we analyzed the raw impedance data with three algorithms and compared bioimpedance svi to transpulmonary thermodilution (svi(td)). | 2008 | 18188539 |
| clinical significance of nuclear factor (nf)-kappab levels in urothelial carcinoma of the urinary bladder. | nuclear factor (nf)-kappab has been reported to be constitutively activated in various human neoplasms. however, its clinical significance in bladder urothelial carcinoma (uc) remains an unresolved issue. we conducted this study trying to elucidate the role of nfkappab in bladder uc and its potential prognostic significance, by quantifying immunohistochemically the levels of p65/rela expression in paraffin-embedded tissue from 116 patients. some of the cases had previously been stained for cellu ... | 2008 | 18188593 |
| crystal structure of a novel bacterial cell-surface flagellin binding to a polysaccharide. | bacterial flagellins are generally self-assembled into extracellular flagella for cell motility. however, the flagellin homologue p5 is found on the cell surface of sphingomonas sp. a1 (strain a1) and binds tightly to the alginate polysaccharide. to assimilate alginate, strain a1 forms a mouthlike pit on the cell surface and concentrates the polymer in the pit. p5 is a candidate receptor that recognizes extracellular alginate and controls pit formation. to improve our understanding of the struct ... | 2008 | 18189419 |
| thyroid function testing in elephant seals in health and disease. | northern elephant seal skin disease (nessd) is a severe, ulcerative, skin condition of unknown cause affecting primarily yearling northern elephant seals (mirounga angustirostris); it has been associated with decreased levels of circulating thyroxine (t4) and triiodothyronine (t3). abnormalities of the thyroid gland that result in decreased hormone levels (hypothyroidism) can result in hair loss, scaling and secondary skin infections. however, concurrent illness (including skin ailments) can sup ... | 2008 | 18190914 |
| effects of adult dysthyroidism on the morphology of hippocampal neurons. | this study investigates the effect of thyroid hormones on the morphology of hippocampal neurons in adult rats. hypo- and hyperthyroidism were induced by adding 0.02% methimazole and 1% l-thyroxine, in drinking water from 40 days of age, respectively. when the rats were 89 days old their brains were removed and stained by a modified golgi method and blood samples were collected in order to measure t4 serum levels. neurons were selected and drawn using a camera lucida. our results show that methim ... | 2008 | 18190975 |
| european eel (anguilla anguilla l.) metallothionein, endocrine, metabolic and genotoxic responses to copper exposure. | this study investigated anguilla anguilla (european eel) physiological and genotoxic responses to copper (cu) and their relation with metallothionein (mt) protection. eels were exposed during 7 days to cu 0.2 micromol/l. mt induction was assessed in gill and liver, revealing significant response only in liver. endocrine responses displayed a plasma free triiodothyronine (t3) and cortisol significant decrease, though the thyroid-stimulating hormone (tsh) and free thyroxine (t4) concentrations wer ... | 2008 | 18192012 |
| diffusion-weighted mri in cervical cancer. | the purpose was to investigate the potential value of apparent diffusion coefficient (adc) measurement with mri in the assessment of cervix cancer. diffusion-weighted mri was performed in 47 patients with cervical carcinoma undergoing chemoradiation therapy and 26 normal controls on a 1.5-t system with a b-value of 600 s/mm(2). figo stage, tumor volume, nodal status, interstitial fluid pressure (ifp) and oxygen measurements were recorded. response was defined as no visible tumor 3-6 months follo ... | 2008 | 18193428 |
| intra-arterial chemoradiation for t3-4 oral cavity cancer: treatment outcomes in comparison to oropharyngeal and hypopharyngeal carcinoma. | surgery followed by radiotherapy is the standard of care for resectable locally advanced oral cavity squamous cell carcinoma (scc). we report the treatment outcomes of patients with t3-t4 scc of the oral cavity treated with chemoradiation, an alternative approach. | 2008 | 18194553 |
| morphological and functional changes in the thyroid gland of methyl thiophanate-injected lizards, podarcis sicula. | the thyroid has been shown to be a target organ for environmental chemicals, specifically endocrine-disrupting contaminants. reptiles are particularly suitable as contaminant biomonitors due to their persistence in a variety of habitats, wide geographic distribution, longevity, and, in many cases, site fidelity. methyl thiophanate is a systemic broad-spectrum fungicide used to prevent and control plant diseases caused by various fungi. the aim of this study was to develop an integrated biologica ... | 2008 | 18196192 |
| [clinical and immunobiochemical study of efficacy and stress-protective properties of thyroliberin at the acute stage of carotid ischemic stroke]. | stress-promoting system is known to be involved in course and outcome of acute stage of ischemic stroke. an important predictor of an unfavorable course of stroke is so-called "low t3-syndrome". therapy with drugs increasing t3 level on the background of reduced reaction of oxidative stress is one of a perspective direction of neuroprotection. the study aimed at investigating thyroliberin influence on a clinical course and an outcome of ischemic atherothrombotic stroke as well as on thyroid horm ... | 2006 | 18196636 |
| thyroid function and body weight programming by neonatal hyperthyroidism in rats - the role of leptin and deiodinase activities. | several authors have shown that secondary hypothyroidism was programed by neonatal thyroxine (t4) treatment. however, the associated changes of body weight (bw) were less studied, especially those related to the body fat proportion. here, we have evaluated the effect of neonatal thyroxine treatment on bw, fat proportion, serum leptin, and thyroid function of 60-day-old rats. wistar rats were treated with thyroxine (50 microg/100 g bw, ip) (t) or saline (s), during the first 10 days of life. bw, ... | 2008 | 18197581 |
| dose estimation and surveillance of mechanical loading interventions for bone loss after spinal cord injury. | the interpretation of the results of previous anti-osteoporosis interventions after spinal cord injury (sci) is undermined by incomplete information about the intervention dose or patient adherence to dose requirements. rehabilitation research as a whole traditionally has struggled with these same issues. the purpose of this case report is to offer proof of the concepts that careful dose selection and surveillance of patient adherence should be integral components in rehabilitation interventions ... | 2008 | 18202080 |
| patterns of failure after combined-modality approaches incorporating radiotherapy for sinonasal undifferentiated carcinoma of the head and neck. | to report the clinical outcome of patients treated with combined-modality approaches for sinonasal undifferentiated carcinoma (snuc) of the head and neck. | 2008 | 18207030 |
| fabrication of ordered metallic and magnetic heterostructured dna-nanoparticle hybrids. | here we provide a method based on enzymatically catalyzed reactions to cleave and ligate dna molecules coated with nanoparticles to fabricate multi-component structures. this is done by simultaneously digesting two solutions of nanoparticle coated dna, one with iron oxide particles the other gold particles, which yields short dna fragments with complementary single stranded overhangs. when added together and re-attached using ligase enzymes multi-component nanoparticle coated structures are form ... | 2008 | 18207375 |
| cervicothoracic postarachnoiditic hydrosyringomyelia secondary to pedicular hook dislocation: case report. | pedicular hook dislocation is a rare complication of spinal instrumentation. we report on the first case of hydrosyringomyelia secondary to intracanalar hook displacement after scoliosis surgery. | 2009 | 18207536 |
| a prospective, open-label study of low-dose total skin electron beam therapy in mycosis fungoides. | to determine the effect of low-dose (4 gy) total skin electron beam therapy as a second-line treatment of stage ib-ii mycosis fungoides in a prospective, open-label study. | 2008 | 18207669 |
| frequency and characteristics of tbii-seronegative patients in a population with untreated graves' hyperthyroidism: a prospective study. | it is claimed that second generation thyrotropin-binding inhibitory immunoglobulin (tbii) assays have a very high sensitivity for the diagnosis of graves' hyperthyroidism (gh). however, studies evaluating the accuracy of tbii have been retrospective in nature and/or gh had not been diagnosed independently of tbii. the aim of the present study, therefore, was to prospectively evaluate the frequency and characteristics of tbii-seronegative patients in a population of untreated gh diagnosed indepen ... | 2008 | 18208575 |
| [abuse of anabolic steroids and its impact on thyroid function]. | the use of anabolic steroids to increase physical performance and for aesthetic ends has reached alarming indices in the last three decades. besides the desired actions, several collateral effects have been described in the literature, such as the development of some types of cancer, ginecomasty, peliosis hepatis, renal insufficiency, virilization, amongst others. the most proeminent effect on human thyroid function is the reduction of thyroxine binding globulin (tbg), with consequent reductions ... | 2007 | 18209883 |
| muscle study in experimental scoliosis in rabbits with costotransversectomy: evidence of ischemic process. | scoliosis involves the central nervous system diseases, ligaments, articulations and skeletal muscles, but there is no consensus on its pathogeny and progression of muscle abnormalities. in this study, we investigate the morphologic changes in the muscle of rabbit submitted to experimental scoliosis, with special emphasis on abnormalities related to blood supply. we studied 26 rabbits subjected to costotransversectomy by pulling out six transverse processes at thoracic level and six rabbits were ... | 2008 | 18210168 |
| effect of different hormonal therapies on thyroid function in surgical menopause: short-term results. | to determine the effects of different hormone replacement therapy (hrt) regimens on thyroid function in surgical menopause. | 2007 | 18210897 |
| relating circulating thyroid hormone concentrations to serum interleukins-6 and -10 in association with non-thyroidal illnesses including chronic renal insufficiency. | because of the possible role of cytokines including interleukins (il) in systemic non-thyroidal illnesses' (nti) pathogenesis and consequently the frequently associated alterations in thyroid hormone (th) concentrations constituting the euthyroid sick syndrome (ess), we aimed in this research to elucidate the possible relation between il-6 & il-10 and any documented ess in a cohort of patients with nti. | 2008 | 18211669 |
| s1 ribosomal protein functions in translation initiation and ribonuclease regb activation are mediated by similar rna-protein interactions: an nmr and saxs analysis. | the ribosomal protein s1, in escherichia coli, is necessary for the recognition by the ribosome of the translation initiation codon of most messenger rnas. it also participates in other functions. in particular, it stimulates the t4 endoribonuclease regb, which inactivates some of the phage mrnas, when their translation is no longer required, by cleaving them in the middle of their shine-dalgarno sequence. in each function, s1 seems to target very different rnas, which led to the hypothesis that ... | 2008 | 18211890 |
| tempol improves renal hemodynamics and pressure natriuresis in hyperthyroid rats. | hyperthyroidism in rats is associated with increased oxidative stress. these animals also show abnormal renal hemodynamics and an attenuated pressure-diuresis-natriuresis (pdn) response. we analyzed the role of oxidative stress as a mediator of these alterations by examining acute effects of tempol, a superoxide dismutase mimetic. the effects of increasing bolus doses of tempol (25-150 micromol/kg) on mean arterial pressure (map), renal vascular resistance (rvr), and cortical (cbf) and medullary ... | 2008 | 18216138 |
| thyroid disrupting chemicals: mechanisms and mixtures. | environmental contaminants are known to act as thyroid disrupting chemicals (tdcs). broadly defined, tdcs are xenobiotics that alter the structure or function of the thyroid gland, alter regulatory enzymes associated with thyroid hormone (th) homeostasis or change circulating or tissue concentrations of ths. for ths, homeostasis is defined as the normal range of ths and tsh in circulation and tissues. tdcs include a wide range chemical structures that act through a variety of mechanisms. concern ... | 2008 | 18217984 |
| structure of escherichia coli exonuclease i in complex with thymidine 5'-monophosphate. | in escherichia coli, exonuclease i (exoi) is a monomeric processive 3'-5' exonuclease that degrades single-stranded dna. the enzyme has been implicated as primarily being involved in repairing frameshift mutations. the structure of the enzyme has previously been determined in a hexagonal space group at 2.4 a resolution. here, the structure of exoi in complex with a nucleotide product, thymidine 5'-monophosphate, is described in an orthorhombic space group at 1.5 a resolution. this new high-resol ... | 2008 | 18219121 |
| [a case of resection of esophageal cancer infiltrating the left main bronchus following preoperative chemo-radiotherapy and resection of metachronous lung metastasis]. | we herein report a case of t4 esophageal carcinoma, which was resected after chemo-radiation therapy. in addition, the metachronous lung metastasis was also resected. a 59-year-old female with esophageal carcinoma, which invaded the left main bronchus, underwent chemo-radiation therapy (the combination of systemic chemotherapy of 5-fu/cddp and external radiation therapy) from january 2004. after the therapy, although the imaging showed a downstaging of esophageal carcinoma, a severe esophageal s ... | 2007 | 18219866 |
| [a clinical study of esophagectomy after chemo-radiation therapy for advanced esophageal carcinoma]. | the aim of this study was to evaluate the efficacy of preoperative neoadjuvant therapy (nat) including chemo-radiation or radiation in patients with t3/t4 advanced esophageal squamous cell carcinoma. we reviewed 115 patients with t3/t4 tumors from january 1994 through august 2006. forty-seven patients received nat, and the remaining 68 patients had surgery alone. of these 47 patients, 14 patients underwent esophagectomy following nat, and 33 patients underwent consecutive chemoradiation. patient ... | 2007 | 18219872 |
| [three cases of unresectable advanced gastric cancer treated with s-1 based chemotherapy after surgical bypass]. | case 1: the patient underwent gastrojejunostomy [t4 (pancreas), n2, p0, cy0] in april 2004, and then 23 courses of chemotherapy with s-1 + doc (40 mg/m2/day 1:3 w). then, the regimen was switched to cpt-11 because of a decreased efficacy of the treatment, and cpt-11 was continued for 10 courses. (the patient was alive for 36 months). case 2: the patient was treated with s-1 [t4 (pancreas), n3, p0, cy0] after surgical bypass in november 2004. after two courses of chemotherapy with s-1, 9 courses ... | 2007 | 18219928 |
| stratified analysis of clinical outcomes in thoracoscopic sympathicotomy for hyperhidrosis. | the primary goal of this study is to identify clinical variables associated with successful surgical treatment for hyperhidrosis and facial blushing. | 2008 | 18222231 |
| single-stranded dna-binding protein recruits dna polymerase v to primer termini on reca-coated dna. | translesion dna synthesis (tls) by dna polymerase v (polv) in escherichia coli involves accessory proteins, including reca and single-stranded dna-binding protein (ssb). to elucidate the role of ssb in tls we used an in vitro exonuclease protection assay and found that ssb increases the accessibility of 3' primer termini located at abasic sites in reca-coated gapped dna. the mutant ssb-113 protein, which is defective in protein-protein interactions, but not in dna binding, was as effective as wi ... | 2008 | 18223256 |
| can impairments of thyroid function test affect prognosis in patients with respiratory failure? | thyroid function test (tft) impairments can be detected in extrathyroidal dysfunction, primarily in chronic obstructive pulmonary disease (copd) with acute respiratory failure (rf). the aims of this study were to: (i) evaluate tft impairments in patients with rf, (ii) compare tft results to a control group without rf and (iii) assess the effects of thyroid dysfunction on clinical outcome and prognosis of rf. the tft parameters were assessed in 65 patients (65.0 +/- 10.0 years, 49 males) with rf ... | 2007 | 18224499 |
| [surgical treatment in non-small cell lung cancer invading to the chest wall (t3) and vertebra (t4)]. | the involvement of the chest wall (t3) or the vertebra (t4) in non-small cell lung cancer (nsclc) is seen at a ratio between 3-8% in patient's undergone surgery. the most important factors affecting the survival in both t3 and t4 tumors are the absence of lymph node invasion and a complete resection application. amount of 162 cases were subjected to operation due to nsclc between january 2004-july 2006. examined retrospectively, these cases were determined to be chest wall invasion in 12 (7.4%) ... | 2007 | 18224507 |
| detection of escherichia coli with fluorescent labeled phages that have a broad host range to e. coli in sewage water. | escherichia coli is used as an indicator microorganism in public health. the conventional way to detect e. coli requires several days to produce a result, because it requires incubation of cells. therefore a rapid and sensitive detection method is needed. t4e-/gfp phage, characterized by suppression of lysozyme and fusion of gfp (green fluorescent protein) to its soc (small outer capsid) protein, was constructed, and it was shown to be able to detect e. coli k12 sensitively within several hours. ... | 2008 | 18225914 |
| fasting-induced changes in the hypothalamus-pituitary-thyroid axis. | fasting induces profound changes in the hypothalamus-pituitary-thyroid (hpt) axis. the alterations observed in humans and rodents are similar in many ways, although they may be more pronounced and more acute in rodents. the molecular mechanisms underlying the resetting of hpt axis regulation in the framework of caloric deprivation are still incompletely understood. fascinating studies in rats and mice have shown a dramatic downregulation of thyrotropin-releasing hormone (trh) gene expression in ... | 2008 | 18225975 |
| changing patterns of vibrio cholerae in sevagram between 1990 and 2005. | a retrospective analysis was done to note changes in prevalence, distribution of biotypes, serotypes, antibiotic susceptibility patterns and phage types of vibrio cholerae isolated in mahatma gandhi institute of medical sciences, sevagram over a period of 16 years. | 2008 | 18227596 |
| polyunsaturated fatty acid metabolizing 15-lipoxygenase-1 (15-lo-1) expression in normal and tumorigenic human bladder tissues. | diets high in fat seem to correspond with an increased risk of certain forms of cancer, including bladder blca. this preliminary study examined the expression and enzyme activity profile of the polyunsaturated fatty acid metabolizing enzyme 15-lipoxygenase-1 (15-lo-1) in human tissues from normal bladder and bladder tumors (stages cis-t3/t4). human tissue samples from normal (donor) bladder and bladder tumors (stages cis-t3/t4; non-bacillus calmette-guerin-treated) were grossly microdissected an ... | 2008 | 18227726 |
| sudden onset of paraplegia caused by hemorrhagic spinal epidural angiolipoma. a case report. | spinal epidural angiolipoma is a rare benign tumor containing vascular and mature adipose elements. a slow progressive clinical course was mostly presented and rarely a fluctuating course during pregnancy. the authors report the original case of spontaneous spinal epidural bleeding resulting from thoracic epidural angiolipoma who presented with hyperacute onset of paraplegia, simulating an extradural hematoma. the patient was admitted with sudden non-traumatic hyperacute paraplegia during a prol ... | 2008 | 18228054 |
| measurement of the acute inflammatory response to walking exercise in copd: effects of pulmonary rehabilitation. | this pilot study concerns the evaluation of the acute cytokine response to exercise and changes in this throughout a 7 week pulmonary rehabilitation programme. | 2007 | 18229573 |
| quantifying protein microstructure and electrostatic effects on the change in gibbs free energy of binding in immobilized metal affinity chromatography. | electrostatic forces play a major role in maintaining both structural and functional properties of proteins. a major component of protein electrostatics is the interactions between the charged or titratable amino acid residues (e.g., glu, lys, and his), whose pk(a) (or the change of the pk(a)) value could be used to study protein electrostatics. here, we report the study of electrostatic forces through experiments using a well-controlled model protein (t4 lysozyme) and its variants. we generated ... | 2008 | 18229947 |
| spinal cord transection modifies ileal fluid and electrolyte transport in rats. | spinal cord injury (sci) is associated with severe autonomic changes, including inhibition of gastrointestinal (gi) motility. gi motility changes are known to affect electrolytes transport and these changes have not been adequately studied after sci. we studied the ileal permeability to fluid and electrolytes in rats submitted to experimental spinal cord transection (sct), between t4 and t5, throughout the first week after sct. sct increased ileal secretion of na+ (p<0.05) and decreased the cl(- ... | 2008 | 18230418 |