| [changes in plasma concentrations of osteoprotegerin before and after levothyroxine replacement therapy in hypothyroid patients]. | to investigate the alteration of plasma osteoprotegerin (opg) concentration before and after levothyroxine (l-t4) replacement therapy and its association with endothelium-dependent arterial dilation in patients with overt hypothyroidism (oht) and subclinical hypothyroidism (sht). | 2007 | 17988532 |
| pseudomalabsorption of thyroid hormones: case report and review of the literature. | many causes of thyroxine malabsorption are described in the literature, but the most common cause of failure of thyroxine therapy is poor patient compliance, or pseudomalabsorption. we describe the case of a female patient who underwent total thyroidectomy for basedow-graves disease. post-operatively, several treatment regimens were employed to achieve euthyroidism, but only injectable thyroxine was found to be effective. to exclude levothyroxine malabsorption, the patient was hospitalized in a ... | 2007 | 17988645 |
| characterization of thyroid hormones and thyroid hormone receptors during the early development of pacific bluefin tuna (thunnus orientalis). | we studied the profiles of 3,5,3'-l-triiodothyronine (t3), thyroxine (t4), and thyroid hormone receptors (trs) in pacific bluefin tuna (thunnus orientalis) during embryonic and post-embryonic development. both t3 and t4 were detected in embryos just before hatching, and it was found that the levels of both were increased in postflexion fish. the thyroid follicles were increased in both size and number in postflexion fish compared with preflexion fish. a trbeta cdna clone was generated by race. t ... | 2008 | 17988667 |
| modulation of cardiac ischemia-sensitive afferent neuron signaling by preemptive c2 spinal cord stimulation: effect on substance p release from rat spinal cord. | the upper cervical spinal region functions as an intraspinal controller of thoracic spinal reflexes and contributes to neuronal regulation of the ischemic myocardium. our objective was to determine whether stimulation of the c2 cervical spinal cord (scs) of rats modified the input signal at the thoracic spinal cord when cardiac ischemia-sensitive (sympathetic) afferents were activated by transient occlusion of the left anterior descending coronary artery (coao). changes in c-fos expression were ... | 2008 | 17989135 |
| tcrgamma-chain gene rearrangement by pcr-based genescan: diagnostic accuracy improvement and clonal heterogeneity analysis in multiple cutaneous t-cell lymphoma samples. | cutaneous t-cell lymphomas are a heterogeneous group of lymphomas where the tumor population emerges within a multiple subclone pattern ("clonal heterogeneity"). pcr analysis has been shown to be useful in the diagnosis of mycosis fungoides (mf) and sézary syndrome (ss). focusing the attention on clonal heterogeneity, the efficacy of the multiplex/heteroduplex (hd) pcr and the genescan (gs) capillary electrophoresis analysis was compared in the early diagnosis of mf/ss, using a multiple sample a ... | 2008 | 17989737 |
| metformin reduces thyrotropin levels in obese, diabetic women with primary hypothyroidism on thyroxine replacement therapy. | context it has been reported that metformin might modify thyroid hormone economy. in two retrospective studies, initiation of treatment with metformin caused suppression of tsh to subnormal levels. objective to prospectively evaluate if administration of metformin to obese, diabetic patients with primary hypothyroidism on stable thyroxine replacement doses modifies tsh levels. patients and methods eight obese, diabetic postmenopausal women with primary hypothyroidism participated in the study. t ... | 2007 | 17992605 |
| acute effects of leptin on 5'-deiodinases are modulated by thyroid state of fed rats. | leptin has been shown to modulate deiodinase type 1 (d1) and type 2 (d2) enzymes responsible for thyroxine (t4) to triiodothyronine (t3) conversion. previously, it was demonstrated that a single injection of leptin in euthyroid fed rats rapidly increased liver, pituitary, and thyroid d1 activity, and simultaneously decreased brown adipose tissue (bat) and hypothalamic d2 activity. we have now examined d1 and d2 activities, two hours after a single subcutaneous injection of leptin (8 microg/100 g ... | 2007 | 17992637 |
| [operation t4 or the implication of the german dental surgeons in the ideology of eugenics and the euthanasia of mental lunatics]. | many things have been said about the t4 operation and the sad role played by nazi doctors. but one could ask the same question about the dentists? they played an important role as they examined, diagnosed and denounciated patients with congenital diseases. their in-house training serving this purpose was very specialised. their implication is even more unquestionable when it came to removing dental gold from the mouth of the victims. once it was collected this gold contributed on a financial lev ... | 2007 | 17992835 |
| experimental neurotisation of the brachial plexus by means of nerve grafting from the corticospinal tract of the proximal spinal cord at the t3-t4 level. | this paper reports experimental work in rats in which the radial nerve was cut at its origin from the brachial plexus and connected by means of a nerve graft to the corticospinal tract of the spinal cord at the t3-t4 level. after surgery, the triceps and extensor muscles of the forearm were able to extend the elbow and the wrist and gave almost normal responses on emg. this reinnervation was no longer cholinergic, as demonstrated by the vecuronium test. because of the drawbacks associated with i ... | 2007 | 17993421 |
| concerted diffusion, clustering, and magnetic properties of mn dopants on a 2 x 2-t4 gan(0001) substrate. | based on first-principles calculations within density functional theory, we propose a kinetic pathway for mn incorporation on reconstructed 2 x 2-t4 gan(0001), characterized by concerted substitution of a ga atom by a mn adatom via a precursor surface site t4. the mn dopants at low densities are randomly distributed, resulting in intrinsic diluted magnetic semiconductors (dms). at high mn densities, planar ferromagnetic clusters oriented in the (0001) plane can be readily formed at relatively lo ... | 2007 | 17995269 |
| evolution of temperate pathogens: the bacteriophage/bacteria paradigm. | taking as a pattern, the t4 and lambda viruses interacting with each other and with their gram-negative host, escherichia coli, a general model is constructed for the evolution of 'gentle' or temperate pathogens. this model is not simply either pure group or kin selection, but probably is common in a variety of host-parasite pairs in various taxonomic groups. the proposed mechanism is that for its own benefit the pathogen evolved ways to protect its host from attack by other pathogens and this h ... | 2007 | 17996103 |
| use of postmastectomy radiotherapy in older women. | clinical trials and guidelines published between 1997 and 2001 concluded that postmastectomy radiotherapy (pmrt) improves overall survival for women with high-risk breast cancer. however, the effect of these findings on current practice is not known. using the surveillance, epidemiology, and end results-medicare cohort, we sought to characterize the adoption of pmrt from 1992 to 2002 and identify risk factors for pmrt omission among high-risk older patients. | 2008 | 17996393 |
| bacteriophage preparation inhibition of reactive oxygen species generation by endotoxin-stimulated polymorphonuclear leukocytes. | it has been known that administration of antibiotics may lead to excessive release of bacterial endotoxins and complicate clinical course of patients with gram-negative infections. this concern may also apply to phages. endotoxin may in turn activate neutrophils to produce reactive oxygen species (ros) that are believed to play an important role in the pathogenesis of multiple organ dysfunction in the course of sepsis. we showed that a purified t4 phage preparation with low-endotoxin content cou ... | 2008 | 17996972 |
| is a positive bladder neck margin truly a t4 lesion in the prostate specific antigen era? results from the search database. | positive bladder neck margins after radical prostatectomy are currently designated as pt4 lesions. however, to our knowledge the prognostic significance of a positive bladder neck margin in the prostate specific antigen era is unknown. we examined the association between positive bladder neck margins and prostate specific antigen recurrence relative to other pathological findings. | 2008 | 17997433 |
| geometry-based sampling of conformational transitions in proteins. | the fast and accurate prediction of protein flexibility is one of the major challenges in protein science. enzyme activity, signal transduction, and ligand binding are dynamic processes involving essential conformational changes ranging from small side chain fluctuations to reorientations of entire domains. in the present work, we describe a reimplementation of the concoord approach, termed tconcoord, which allows a computationally efficient sampling of conformational transitions of a protein ba ... | 2007 | 17997973 |
| multicentric epithelioid angiosarcoma of the spine: a case report of a rare bone tumor. | epithelioid angiosarcoma (ea) is a high-grade sarcoma of vascular origin. ea is a rare variant of angiosarcoma. it is characterized by large cells with an epethelioid morphology. ea has been reported in sites like skin thyroid, adrenal gland, soft tissue, and rarely in bone. | 2007 | 17998131 |
| breast cancer in males: a pgimer experience. | male breast cancer is a rare disease representing 1% of all breast cancers and less than 1% of all cancers in men. because of its rarity, carcinoma breast has not been studied extensively and this prompted us to carry out this retrospective study. the aim of the study was to observe the clinical and pathological features, evaluate the prognostic factors and to co-relate the outcome in patients of male breast cancer. | 2005 | 17998622 |
| patterns of relapse in locally advanced breast cancer treated with neoadjuvant chemotherapy followed by surgery and radiotherapy. | to define the clinical and pathological predictors of locoregional recurrence (lrr) in locally advanced breast cancer (labc) patients treated with neoadjuvant chemotherapy (nact). | 2007 | 17998727 |
| a prospective study evaluating surgery and chemo radiation in muscle invasive bladder cancer. | the aim of our study was to compare the two standard treatment approaches in muscle invasive carcinoma of urinary bladder--radical cystectomy and chemo radiation. | 2007 | 17998728 |
| impact of systemic hypoxemia on cancer aggressiveness and circulating vascular endothelial growth factors a and c in gastroesophageal cancer patients with chronic respiratory insufficiency. | due to the common etiologic factor, a considerable number of esophagogastric cancer patients suffer from respiratory insufficiency in course of chronic obstructive pulmonary disease, primary to cancer. systemic hypoxemia may account for poor oxygenation of tumor tissue-a main driving force of tumor neoangiogenesis. we hypothesized that in cancer patients with respiratory insufficiency, systemic hypoxemia may be related to enhanced aggressiveness of cancer on one side and to the elevation of angi ... | 2007 | 18004252 |
| optimal organ-sparing intensity-modulated radiation therapy (imrt) regimen for the treatment of locally advanced anal canal carcinoma: a comparison of conventional and imrt plans. | to compare the dosimetric advantage of three different intensity-modulated radiation therapy (imrt) plans to a three dimensional (3d) conventional radiation treatment for anal cancer with regards to organs-at-risk (oar) avoidance, including iliac bone marrow. | 2007 | 18005443 |
| endocrine stress response and inflammatory activation during cabg surgery. a randomized trial comparing remifentanil infusion to intermittent fentanyl. | our aim was to compare a continuous infusion of remifentanil with intermittent boluses of fentanyl as regards the perioperative hormonal stress response and inflammatory activation in coronary artery bypass graft patients under sevoflurane-based anaesthesia. | 2008 | 18005471 |
| circumferential margin involvement is the crucial prognostic factor after multimodality treatment in patients with locally advanced rectal carcinoma. | after preoperative (radio)chemotherapy, histologic determinants for prognostication have changed. it is unclear which variables, including assessment of tumor regression, are the best indicators for local recurrence and survival. | 2007 | 18006762 |
| proximal junctional kyphosis in adolescent idiopathic scoliosis after 3 different types of posterior segmental spinal instrumentation and fusions: incidence and risk factor analysis of 410 cases. | retrospective study. | 2007 | 18007253 |
| bladder-sparing, combined-modality approach for muscle-invasive bladder cancer: a multi-institutional, long-term experience. | the authors evaluated their long-term experience with combined-modality, conservative treatment in patients with muscle-invasive bladder cancer. | 2008 | 18008364 |
| [outline of general rules for the description of thyroid cancer (6th edition)]. | general rules for the description of thyroid tumors is essential for the medical practice on thyroid tumors. the japanese society of thyroid surgery has published the general rules since 1977, and has revised it 5 times according to the revision of uicc tnm classification or who histological classification by the latest 6th edition of the rules published in 2005. in the present revision of the rules tnm and ex (extra thyroidal invasion) classifications were reconsidered as compared with uicc tnm ... | 2007 | 18018553 |
| [our surgical strategy for thyroid carcinoma]. | according to our previous data on papillary thyroid cancer (ptc), recurrences are related to lymph node ratio (number of metastatic lymph nodes/number of dissected nodes) and lymphatic spread of ptc is more symmetrical than previously thought. therefore, neck dissection should be performed symmetrically. our basic procedure for clinically evident ptc is total thyroidectomy with central neck dissection. for the cases with jugular chain adenopathy and/or t3, t4 tumor, bilateral lateral neck dissec ... | 2007 | 18018566 |
| improvement of dna adenylation using t4 dna ligase with a template strand and a strategically mismatched acceptor strand. | dna with a 5'-adenylpyrophosphoryl cap (5'-adenylated dna; appdna) is an activated form of dna that is the biochemical intermediate of the reactions catalyzed by dna ligase, rna ligase, polynucleotide kinase, and other nucleic acid modifying enzymes. 5'-adenylated dna is also useful for in vitro selection experiments. efficient preparation of 5'-adenylated dna is therefore desirable for several biochemical applications. here we have developed a dna adenylation procedure that uses t4 dna ligase a ... | 2008 | 18022669 |
| an unusual case of galactorrhea in a postmenopausal woman complicating breast reduction. | galactorrhea is a relatively common condition, but has rarely been seen following breast reduction surgery. to date there are only seven cases reported in the literature, all in premenopausal women. postsurgical galactorrhea is a diagnosis of exclusion and differential diagnosis is extensive. common causes should be excluded first. we present the case of a 56-year-old postmenopausal woman who underwent bilateral breast reduction and developed galactorrhea 2 months postoperatively. mri scan of th ... | 2009 | 18023264 |
| cardiovascular assessment of hyperthyroid patients with multinodular goiter before and after radioiodine treatment preceded by stimulation with recombinant human tsh. | treatment of large multinodular goiter (mng) with radioiodine preceded by recombinant human thyrotropin (0.1 mg rhtsh) has been shown to be a safe alternative for patients with comorbidities that preclude surgery. however, the increase in serum thyroid hormones that follows both treatments may be harmful for some patients, particularly those with underlying cardiovascular disease. in this study, we evaluated cardiac parameters (clinical, ecg, 24-h holter, doppler echocardiogram, treadmill stress ... | 2007 | 18026694 |
| post-traumatic syringomyelia producing paraplegia in an infant. | post-traumatic syringomyelia is described in adults after spinal trauma but extremely rarely seen in children, especially in the first year of life. | 2008 | 18026959 |
| optimal endotracheal tube tip position in extremely premature infants. | although right main bronchus intubation is associated with adverse consequences, the optimal endotracheal tube (ett) tip position above the carina in neonates is not known. the aim of this study was to determine the association between ett tip position and adverse pulmonary effects as assessed by chest radiographs (cxrs). lung aeration was examined after masking ett positions in the first two cxrs taken after birth in 74 consecutive ventilated premature infants <or= 28 weeks. all the cxrs of the ... | 2008 | 18027311 |
| outcomes and prognostic variables in adenoid cystic carcinoma of the head and neck: a recent experience. | to analyze the recent experience of patients with adenoid cystic carcinoma treated with radiation therapy at memorial sloan-kettering cancer center. | 2008 | 18029108 |
| comparison of enzymatic recognition of dna-duplexes containing no-induced lesions by dna-relevant enzymes. | nitric oxide (no) produced in inflamed tissues is known to cause dna damage by nitrosation or oxidation of base moieties. for investigating the biophysical and biochemical properties of dna lesions induced by nitric oxide, we prepared synthetic dna oligomers and analyzed melting temperature (t(m)) or enzymatic recognition of dna strands containing oxanine (oxa) and hypoxanthine (hyp), using guanine (gua) or adenine (ade) as control bases, respectively. for enzymatic reaction by dna-relevant enzy ... | 2007 | 18029781 |
| management and outcome of patients with mucoepidermoid carcinoma of major salivary gland origin: a single institution's 30-year experience. | mucoepidermoid carcinoma (mec) is one of the most frequent epithelial malignancies of the salivary glands. prediction of clinical outcome of mec is challenging. | 2008 | 18030166 |
| survival and health outcomes after cytoreductive surgery with intraperitoneal hyperthermic chemotherapy for disseminated peritoneal cancer of appendiceal origin. | cytoreductive surgery with intraperitoneal hyperthermic chemotherapy for peritoneal carcinomatosis of appendiceal origin can alleviate symptoms and prolong survival. this aggressive therapy may impair patient quality of life (qol). the purpose of this study was to monitor health outcomes before and after treatment. | 2008 | 18030535 |
| [visual search and event-related potentials in the extrastriate cortical areas in humans]. | parameters of visual search (reaction time, mistakes) were investigated in 11 young healthy volunteers, under changing parameters of target symbol (form, color and location) in surroundings of white distracters (flankers). in 6 cortical leads: p3, p4, t3, t4, t5, t6, monopolar event-related potentials (erps) were registered and analyzed for the late endogenous components: n2, p3, because these very components have changed under verifying of search (so called late selection). in the hard search ( ... | 2007 | 18030798 |
| effects of light to moderate alcohol consumption on thyroid volume and thyroid function. | to examine a possible relationship between alcohol consumption and thyroid volume and function. | 2008 | 18031329 |
| a treatment planning analysis of inverse-planned and forward-planned intensity-modulated radiation therapy in nasopharyngeal carcinoma. | to compare dose-volume histograms of target volumes and organs at risk in 57 patients with nasopharyngeal carcinoma (npc) with inverse- (ip) or forward-planned (fp) intensity-modulated radiation treatment (imrt). | 2007 | 18035216 |
| [adenosine preconditioning reduces myocardial injury in patients undergoing off-pump coronary artery bypass grafting surgery]. | to evaluate the effects of adenosine on reducing myocardial injuries in patients undergoing off-pump coronary artery bypass grafting (opcab). | 2007 | 18036291 |
| restriction endonuclease inhibitor ipi* of bacteriophage t4: a novel structure for a dedicated target. | phage t4 protects its dna from the two-gene-encoded gmrs/gmrd (glucose-modified hydroxymethylcytosine restriction endonuclease) ct of pathogenic escherichia coli, ct596, by injecting several hundred copies of the 76-amino-acid-residue nuclease inhibitor, ipi*, into the infected host. here, the three-dimensional solution structure of mature ipi* is reported as determined by nuclear magnetic resonance techniques using 1290 experimental nuclear overhauser effect and dipolar coupling constraints ( a ... | 2008 | 18037438 |
| semiquantitative rt-pcr measurement of gene expression in rat tissues including a correction for varying cell size and number. | abstract: | 2007 | 18039356 |
| monitoring of the sublingual microcirculation in cardiac surgery using orthogonal polarization spectral imaging: preliminary results. | the recent introduction of orthogonal polarization spectral imaging enables the direct visualization of the microcirculation of man without imaging enhancing dyes. the authors studied the changes in microvascular perfusion of sublingual mucosa during cardiac surgery with the use of cardiopulmonary bypass (cpb) using this optical method. | 2007 | 18043062 |
| prognostic significance of multiple molecular markers for patients with stage ii colorectal cancer undergoing curative resection. | the aim of this study was to determine whether our constructed high-sensitivity colorimetric membrane-array method could detect circulating tumor cells (ctcs) in the peripheral blood of stage ii colorectal cancer (crc) patients and so identify a subgroup of patients who are at high risk for relapse. | 2007 | 18043108 |
| comparison between 3-t magnetic resonance imaging and multi-detector row computed tomography for the preoperative evaluation of rectal cancer. | to compare prospectively between 3-t magnetic resonance imaging (mri) and multidetector row computed tomography (mdct) for the local staging of rectal cancer. | 2007 | 18043346 |
| multiple short-segment laminoplasties in children: a novel technique to avoid postoperative spinal deformity. | spinal deformity is a recognized important complication after laminectomies, especially in children. even with laminoplasties, spinal deformity is a concern, especially when laminoplasties involve multiple levels. the author reports a novel technique to avoid postoperative spinal deformity using multiple short-segment replacement laminoplasties to access pathology over a long segment of the intraspinal space. | 2008 | 18043924 |
| complete clinical response after preoperative chemoradiation in rectal cancer: is a "wait and see" policy justified? | a proportion of patients, who receive preoperative chemoradiation for locally advanced (t3, t4, nx) rectal cancer achieve a complete clinical response and a pathologic complete response in the region of 15 to 30 percent. support is growing in the united kingdom for the concept of "waiting to see" and not proceeding to radical surgery when a complete clinical response is observed. the purpose of this review was to use a literature search to assess how often complete clinical response is achieved ... | 2008 | 18043968 |
| effects of an acute treatment with l-thyroxine on memory, habituation, danger avoidance, and on na+, k+ -atpase activity in rat brain. | thyroid hormones (ths) have a relevant action on brain development and maintenance. by using an acute treatment to induce a hyperthyroid animal model, we aimed at investigating the effect of an altered ths levels on learning and memory and on the activity of na(+), k(+)-atpase in the rat brain. our results have shown that the acute treatment with l-t4 did not alter the retrieval of the inhibitory avoidance task, but had a significant effect on the elevated plus maze and on open-field performance ... | 2007 | 18045151 |
| thyroid function and volume in epileptic children using carbamazepine, oxcarbazepine and valproate. | the aim of the present study was to investigate the effects of carbamazepine (cbz), oxcarbazepine (oxc), and valproic acid (vpa) on thyroid function and volume in epileptic children. | 2007 | 18045279 |
| third degree atrioventricular block and accelerated idioventricular rhythm associated with a heart base chemodectoma in a syncopal rottweiler. | a 7-year-old male intact rottweiler was presented with a 1-week history of lethargy, anorexia, vomiting and multiple syncopal events. the results of the clinical examination and electrocardiography were consistent with a third degree atrioventricular block and an intermittent accelerated idioventricular rhythm. haematology, serum biochemistry, serology for borrelia burgdorferi, blood culture, total t4, thoracic radiography and echocardiography did not reveal the cause of the arrhythmia. response ... | 2007 | 18045349 |
| molecular characterization of l-413c, a p2-related plague diagnostic bacteriophage. | our analysis of the plague diagnostic phage l-413c genome sequence and structure reveals that l-413c is highly similar and collinear with enterobacteriophage p2, though important differences were found. of special interest was the mosaic nature of the tail fiber protein h in l-413c, given the differentiating specificity of this phage for yersinia pestis vs. yersinia pseudotuberculosis. while the n-terminal 207 and c-terminal 137 amino acids of l-413c display significant homology with the p2 h pr ... | 2008 | 18045639 |
| design and biophysical characterization of novel polycationic epsilon-peptides for dna compaction and delivery. | design and solid-phase synthesis of novel and chemically defined linear and branched -oligo( l-lysines) (denoted -k n, where n is the number of lysine residues) and their alpha-substituted homologues (epsilon-(r)k10, epsilon-(y)k10, epsilon-(l)k10, epsilon-(yr)k10, and epsilon-(lyr)k10) for dna compaction and delivery are reported. the ability to condense viral (t2 and t4) and plasmid dna as well as the size of -peptide dna complexes under different conditions was investigated with static and dy ... | 2008 | 18047291 |
| cardiovascular risk in elderly hypothyroid patients. | overt hypothyroidism (oh) and subclinical hypothyroidism (sh) are frequently found in the elderly. oh is associated with several functional cardiovascular abnormalities and increased risk of atherosclerosis resulting from hypertension associated to atherogenic lipid profile. other potential atherogenic factors involved in oh are increased circulating c-reactive protein and homocysteine, increased arterial stiffness, endothelial dysfunction, and altered coagulation parameters. similar (although m ... | 2007 | 18047429 |
| combined spinal and epidural anaesthesia with chloroprocaine for hysterectomy. | 1. the aim of the present study was to determine the clinical efficacy and safety of chloroprocaine (cp) for gynaecological surgery. 2. one hundred and twenty gynaecological patients scheduled for hysterectomy were divided randomly into four groups: group a (n = 30), 2.5% cp 1.0 ml; group b (n = 30), 2.5% cp 1.2 ml; group c (n = 30), 2.5% cp 1.4 ml; and group d (n = 30), 2.5% cp 1.6 ml. the dose of cp used in each group was mixed with 1 ml vehicle containing 5% glucose and 1.5% ephedrine. spinal ... | 2008 | 18047629 |
| modified cold pressor test by cold application to the foot after spinal cord injury: suggestion of hemodynamic control by the spinal cord. | study hemodynamic responses to cold application to the foot (caf) to explore the autonomic cardiovascular control by the spinal cord. | 2007 | 18049135 |
| adjuvant chemotherapy for stage ii colon cancer: influence of care structures' characteristics on a controversial clinical practice. | adjuvant chemotherapy for stage ii colon cancer is a controversial practice and is not recommended by the french consensus conference outside of therapeutic trial. | 2007 | 18049170 |
| [radiotherapy of rectal cancer]. | of the approximately 1,100 new cases of rectal cancer in norway annually, many can be cured by surgery alone, but a large group of patients need supplemental treatment. we here present the national consensus for radiotherapy of rectal cancer. | 2007 | 18049501 |
| prospective investigation into the influence of various stressors on skin impedance. | the control mechanisms during general anesthesia include circulation parameters and vegetative reactions. a possible way to quantify vegetative reactions is to measure the impedance of the skin. an activation of the eccrine sweat glands via sympathetic sudomotor fibers induces a secretion of sweat, which generates a drop in skin impedance. the aim of the present study was to investigate the influence which different stressors and measurement electrodes have upon skin impedance. | 2008 | 18049905 |
| development of a novel vector system for programmed cell lysis in escherichia coli. | although widely used as a host for recombinant protein production, escherichia coli is unsuitable for massive screening of recombinant clones, owing to its poor secretion of proteins. a vector system containing t4 holin and t7 lysozyme genes under the control of the ptsg promoter derivative that is inducible in the absence of glucose was developed for programmed cell lysis of e. coli. because e. coli harboring the vector grows well in the presence of glucose, but is lysed upon glucose exhaustion ... | 2007 | 18051328 |
| the prevalence of iodine deficiency in women of reproductive age in the united states of america. | to review the iodine status of women as assessed through national health and nutrition examination surveys from 1971 to 2002.design and setting: national normative estimates of iodine status of the civilian, non-institutionalized population in the united states of america. | 2007 | 18053275 |
| evaluating iodine deficiency in pregnant women and young infants-complex physiology with a risk of misinterpretation. | to review methods for evaluating iodine deficiency in pregnant women and young infants and to discuss factors to be considered in the interpretation of their results. | 2007 | 18053278 |
| iodine deficiency and brain development in the first half of pregnancy. | an inadequate supply of iodine during gestation results in damage to the foetal brain that is irreversible by mid-gestation unless timely interventions can correct the accompanying maternal hypothyroxinemia. even mild to moderate maternal hypothyroxinemia may result in suboptimal neurodevelopment. this review mainly focuses on iodine and thyroid hormone economy up to mid-gestation, a period during which the mother is the only source for the developing brain of the foetus. the cerebral cortex of ... | 2007 | 18053280 |
| recombinant human thyroid stimulating hormone does not acutely change serum osteoprotegerin and soluble receptor activator of nuclear factor-kappabeta ligand in patients under evaluation for differentiated thyroid carcinoma. | some extra-thyroid actions of thyroid stimulating hormone (tsh), such as an in vitro action on bone, have been described. our aim was to evaluate in vivo the acute effect of a recombinant human tsh (rhtsh)-induced tsh surge on osteoprotegerin (opg) and receptor activator of the nuclear factor-kappabeta (rank-l) levels in patients under levo-thyroxine (l-t4) therapy. | 2007 | 18055421 |
| scoliosis correction with pedicle screws in duchenne muscular dystrophy. | this report describes the spinal fixation with pedicle-screw-alone constructs for the posterior correction of scoliosis in patients suffering from duchenne muscular dystrophy (dmd). twenty consecutive patients were prospectively followed up for an average of 5.2 years (min 2 years). all patients were instrumented from t3/t4 to the pelvis. pelvic fixation was done with iliac screws similar to galveston technique. the combination of l5 pedicle screws and iliac screws provided a stable caudal found ... | 2008 | 18057966 |
| concurrent chemoradiotherapy or endoscopic stenting for advanced squamous cell carcinoma of esophagus: a case-control study. | we evaluated the role of chemoradiotherapy (crt) for patients with inoperable squamous esophageal cancer. | 2008 | 18057993 |
| survival benefits of pancreatoduodenectomy for gastric cancer: relationship to the number of lymph node metastases. | pancreatoduodenectomy (pd) for advanced gastric cancer is rarely performed because of the high frequency of associated morbidity and mortality. the aim of this study was to determine the limited indication of pd for advanced gastric cancer. | 2008 | 18060424 |
| poor nutrient intakes during 1-year follow-up with community-dwelling older adults with early-stage alzheimer dementia compared to cognitively intact matched controls. | decreased food intakes, eating behavior disturbances, and loss of body weight are particularly significant problems among those with alzheimer dementia. to follow the natural evolution of dietary and nutrition status among elderly community-dwelling adults with alzheimer dementia. | 2007 | 18060894 |
| [cloning and analysis of the vibrio harveyi dam gene]. | the dna adenine methylase (dam) gene was cloned by degenerate pcr from vibrio harveyi strain t4. the gene was 840bp in length and encoded a putative protein of 279 amino acids that shared relatively high homology with the dam of other vibrios, especially with that of v. parahaemolyticus (96% in identity). the v. harveyi dam gene was subcloned into plasmid pbr322 and the resulting plasmid pbd was introduced into the e. coli strain er2925 in which the dam gene had been knocked out. dpn i, dpn ii, ... | 2007 | 18062262 |
| structure and orientation of t4 lysozyme bound to the small heat shock protein alpha-crystallin. | we have determined the structural changes that accompany the formation of a stable complex between a destabilized mutant of t4 lysozyme (t4l) and the small heat shock protein alpha-crystallin. using pairs of fluorescence or spin label probes to fingerprint the t4l tertiary fold, we demonstrate that binding disrupts tertiary packing in the two domains as well as across the active-site cleft. furthermore, increased distances between i and i+4 residues of helices support a model in which the bound ... | 2008 | 18062989 |
| thyroid hormone status and pituitary function in adult rats given oral doses of perfluorooctanesulfonate (pfos). | perfluorooctanesulfonate (pfos) is widely distributed and persistent in humans and wildlife. prior toxicological studies have reported decreased total and free thyroid hormones in serum without a major compensatory rise in thyrotropin (tsh) or altered thyroid gland histology. although these animals (rats, mice and monkeys) might have maintained an euthyroid state, the basis for hypothyroxinemia remained unclear. we undertook this study to investigate the causes for the pfos-induced reduction of ... | 2008 | 18063289 |
| is thyroid autoimmunity a risk factor for developing primary myelodysplastic syndrome? | thyroid disease has been associated with leukemia and lymphoma. no previous study using clinical and laboratory data has explored whether thyroid disease and especially autoimmune thyroid disease (atd) is associated with myelodysplastic syndrome (mds) risk. in this case-control study, we investigated the association of atd with mds. | 2008 | 18064534 |
| nongenomic regulation of glutamatergic neurotransmission in hippocampus by thyroid hormones. | thyroid hormones (ths) are well known for their genomic effects but recently attention has focused also on their nongenomic actions as rapid modulators of membrane receptors. here we show that thyroxine (t4) and 3,3',5'-l-triiodothyronine (t3) rapidly decrease n-methyl-d-aspartate (nmda)-evoked currents in rat hippocampal cultures with potency in the micromolar range. the effect is not mediated by glutamate or glycine binding sites as an increase in agonist or glycine concentration does not alte ... | 2008 | 18065155 |
| eeg of chronic marijuana users during abstinence: relationship to years of marijuana use, cerebral blood flow and thyroid function. | marijuana abuse is associated with neurological changes including increases in frontal eeg alpha during abstinence. research is needed to assess to what extent these eeg patterns are indicative of cerebral perfusion deficits. | 2008 | 18065267 |
| a simple ligation-based method to increase the information density in sequencing reactions used to deconvolute nucleic acid selections. | herein, a method is described to increase the information density of sequencing experiments used to deconvolute nucleic acid selections. the method is facile and should be applicable to any selection experiment. a critical feature of this method is the use of biotinylated primers to amplify and encode a bamhi restriction site on both ends of a pcr product. after amplification, the pcr reaction is captured onto streptavidin resin, washed, and digested directly on the resin. resin-based digestion ... | 2008 | 18065718 |
| [traumatic lumbosacral fracture dislocation: a case report and review of the literature]. | lumbosacral dislocation is uncommon. we report a case of traumatic lumbosacral dislocation which occurred in a 33-year-old pedestrian traffic accident victim. the posterior impact produced lumbar injury with diffuse pain exacerbated at the lumbosacral junction. ecchymotic diffusion involving the entire lumbar region fluctuated due to the presence of a subcutaneous hematoma. the neurological examination revealed incomplete l5 paraplegia. standard x-rays revealed l5-s1 spondylolisthesis and fractu ... | 2007 | 18065885 |
| long-term results after dissection of positive thoracic lymph nodes in patients with esophageal squamous cell carcinoma. | although thoracic lymph node metastasis in patients with thoracic esophageal squamous cell carcinoma (scc) has been reported to be a negative risk factor for long-term survival, only a few studies have evaluated the clinicopathologic difference between the impact of metastasis to the paraesophageal lymph nodes and to the nonparaesophageal lymph nodes. the purpose of this study was to evaluate surgical outcome after the clearance of metastatic thoracic lymph nodes. | 2008 | 18066616 |
| [therapeutic effects of transsphincteric surgery in treating rectal tumors: a report of 97 cases]. | to evaluate the role of transsphincteric surgery in local excision of mid and lower rectal tumors. | 2007 | 18067707 |
| [construction of a recombinant pim3-expressing plasmid and expression and activity thereof: experiment with rats]. | to construct a plasmid expressing green fluorescent protein (gfp) and gene of pim-3, a member of the serine/threonine kinase family, and to investigate the in vivo expression of the construct and its effect on cell apoptosis. | 2007 | 18067836 |
| stereochemical criteria for prediction of the effects of proline mutations on protein stability. | when incorporated into a polypeptide chain, proline (pro) differs from all other naturally occurring amino acid residues in two important respects. the phi dihedral angle of pro is constrained to values close to -65 degrees and pro lacks an amide hydrogen. consequently, mutations which result in introduction of pro can significantly affect protein stability. in the present work, we describe a procedure to accurately predict the effect of pro introduction on protein thermodynamic stability. seven ... | 2007 | 18069886 |
| [treatment effects of magnetic twin-block appliance for class ii cases]. | to evaluate the effects of magnetic twin-block appliance in the treatment of skeletal class ii cases. | 2007 | 18070424 |
| one-base excess adaptor ligation method for walking uncloned genomic dna. | this report describes a novel and efficient method for walking the sequence of a genomic deoxyribonucleic acid (dna) from a known region to an unknown region based on an oligodeoxynucleotide (oligo) cassette-mediated polymerase chain reaction technique. in this method, genomic dna is digested by a restriction enzyme that generates a sticky 5'-end, followed by ligation of a one-base excess oligo-adaptor using t4 dna ligase. the adaptor consists of two complementary oligos that form the same stick ... | 2008 | 18071644 |
| type 2 deiodinase polymorphism (threonine 92 alanine) predicts l-thyroxine dose to achieve target thyrotropin levels in thyroidectomized patients. | type 2 deiodinase (d2) converts t4 in t3 in several human tissues, including hypothalamus and pituitary, and, therefore, plays a pivotal role in the negative feedback regulation of tsh secretion. a common variant of the gene, threonine (thr) 92 alanine (ala), has been identified and associated with decreased d2 enzymatic activity. | 2008 | 18073314 |
| impaired immune responses in tuberculosis patients are related to weight loss that coexists with an immunoendocrine imbalance. | the study's objective was to examine whether factors related to the host status may bear some relation with the profile of the immune response displayed by tuberculosis (tb) patients. the in vitro immune response (antigen-driven lymphoproliferation and cytokine production) and the presence of alcoholism or disease-related factors, like heart and respiratory rates, and weight loss (body mass index, bmi) were investigated in 31 males with active, untreated tb. compared to 16 age-matched healthy ma ... | 2007 | 18073514 |
| the continuum of translation research in genomic medicine: how can we accelerate the appropriate integration of human genome discoveries into health care and disease prevention? | advances in genomics have led to mounting expectations in regard to their impact on health care and disease prevention. in light of this fact, a comprehensive research agenda is needed to move human genome discoveries into health practice in a way that maximizes health benefits and minimizes harm to individuals and populations. we present a framework for the continuum of multidisciplinary translation research that builds on previous characterization efforts in genomics and other areas in health ... | 2007 | 18073579 |
| maternal hyperthyroidism in rats impairs stress coping of adult offspring. | given the evidence that maternal hyperthyroidism (mh) compromises expression of neuronal cytoskeletal proteins in the late fetal brain by accelerated neuronal differentiation, we investigated possible consequences of mh for the emotional and cognitive functions of adult offspring during acute and subchronic stress coping. experimental groups consisted of male rat offspring from mothers implanted with osmotic minipumps infusing either thyroxine (mh) or vehicle (ctrl) during pregnancy. body weight ... | 2008 | 18074386 |
| sleeve pneumonectomy for lung cancer--survival and complications (single-center experience with 42 patients). | sleeve pneumonectomy is challenging both from the technical and oncological standpoint. the benefit of induction treatment is still under investigation. | 2007 | 18074910 |
| haemodynamic changes after spinal cord transection are anaesthetic agent dependent. | 1 to evaluate the effect of high spinal cord transection (sct), between t4 and t5, on the mean arterial pressure (map) and heart rate in animals anaesthetized with different anaesthetic agents: ether (n = 12), 20% urethane, 1.2 g kg(-1) (n = 12), 2% tri-bromide-ethanol, 200 mg kg(-1) (n = 12); chloral hydrate and urethane, 75 and 525 mg kg(-1) respectively (n = 12). 2 in the animals anaesthetized with ether or urethane, sct caused an immediate major drop in map, with hypotension and bradycardia ... | 2007 | 18076477 |
| sentinel lymph node biopsy in squamous cell carcinoma of the head and neck: where we stand now, and where we are going. | this review was performed to evaluate the existing literature on sentinel lymph node biopsy (slnb) for early-stage oral and oropharyngeal head and neck squamous cell carcinoma (hnscc) in clinically negative (n0) necks. | 2007 | 18076844 |
| real-time observation of bacteriophage t4 gp41 helicase reveals an unwinding mechanism. | helicases are enzymes that couple atp hydrolysis to the unwinding of double-stranded (ds) nucleic acids. the bacteriophage t4 helicase (gp41) is a hexameric helicase that promotes dna replication within a highly coordinated protein complex termed the replisome. despite recent progress, the gp41 unwinding mechanism and regulatory interactions within the replisome remain unclear. here we use a single tethered dna hairpin as a real-time reporter of gp41-mediated dsdna unwinding and single-stranded ... | 2007 | 18077411 |
| [a case of thoracic esophageal cancer with invasion of the main bronchus in which long-term survival with high quality of life was achieved through chemoradiotherapy, esophageal bypass and then additional chemotherapy]. | we administered chemoradiotherapy consisting of 5-fluorouracil and cisplatin combined with radiation (59.8 gy) to a patient with locally advanced esophageal cancer (t4 (left main bronchus) n2m0, stage iva). the cancer disappeared completely after the chemoradiotherapy. however, because an esophagobronchial fistula occurred, an esophageal bypass was performed according to the method of postlethwait. thereafter, multiple lung metastases appeared, which we treated with paclitaxel 120-210 mg/body du ... | 2007 | 18079631 |
| macrophage migration inhibitory factor in pediatric patients undergoing surgery for congenital heart repair. | macrophage migration inhibitory factor (mif), a proinflammatory mediator, has been shown to be elevated following heart surgery in adults and may be associated with several postoperative complications, including cardiac and pulmonary dysfunction. in this study, we aimed to measure perioperative plasma mif, interleukin (il)-8, and free t4 in 20 children age <4 years undergoing surgical repair of congenital heart lesions with left ventricular volume overload, and to determine whether the response ... | 2008 | 18079996 |
| aging and drinking problems among mature adults: the moderating effects of positive alcohol expectancies and workforce disengagement. | this article examines the relationship between aging and drinking problems among mature workers and the moderating effects of positive alcohol expectancies (paes) and workforce disengagement. | 2008 | 18080075 |
| brown adipose tissue sympathetic nerve activity is potentiated by activation of 5-hydroxytryptamine (5-ht)1a/5-ht7 receptors in the rat spinal cord. | in urethane-chloralose anesthetized, neuromuscularly blocked, ventilated rats, microinjection of nmda (12 pmol) into the right fourth thoracic segment (t4) spinal intermediolateral nucleus (iml) immediately increased ipsilateral brown adipose tissue (bat) sympathetic nerve activity (sna; peak +492% of control), expired co2 (+0.1%) heart rate (+48 beats min(-1)) and arterial pressure (+8 mmhg). the increase in bat sna evoked by t4 iml microinjection of nmda was potentiated when it was administere ... | 2008 | 18082230 |
| lycopus europaeus (gypsywort): effects on the thyroidal parameters and symptoms associated with thyroid function. | the aim of the prospective two-armed open study was to examine the effect of lycopi europaei herba on thyroid function and on associated symptoms during a 3-month follow-up phase. the study population consisted of patients with a basal tsh<1.0 mu/l and hyperthyroidism-associated symptoms. for the first time, the t3/t4 excretion in 24h urine was measured as a primary objective parameter. as secondary parameters, further hormones, the general condition and the symptoms associated with hyperthyroid ... | 2008 | 18083505 |
| repair of an infrarenal abdominal aortic aneurysm is associated with persistent left ventricular diastolic dysfunction. | left ventricular (lv) diastolic function has received much attention recently. however, few studies have evaluated lv diastolic function in the perioperative period. the aim of this study was to elucidate perioperative changes in diastolic function using tissue doppler imaging (tdi) in patients undergoing repair of an infrarenal abdominal aortic aneurysm (aaa). | 2007 | 18084132 |
| effects of concanavalin a on intestinal brush border enzyme activity in broiler chickens. | 1. the effects of concanavalin a (con a) on enzymes from the intestinal brush border were studied using membrane vesicles (bbmv) prepared from 3- and 6-week-old broiler chickens. 2. maltase, sucrase, phytase, alkaline phosphatase and leucine aminopeptidase activities were assayed in bbmv in the absence (t0) or presence (t1) of con a, or in the presence of casein (t2). disaccharidase specific activities were assayed in the presence of con a that had been pre-incubated with the enzyme (t3) or with ... | 2007 | 18085452 |
| topical treatment with ogg1 enzyme affects uvb-induced skin carcinogenesis. | nonmelanoma skin cancer resulting from uvb exposure is a large and growing problem in the united states. production of reactive oxygen species (ros) during the uvb-induced inflammatory response results in the formation of oxidative dna adducts such as 8-hydroxy-2-deoxyguanine (8-oxo-dg), which have been shown to contribute to the development of this cancer. the 8-oxoguanine dna glycosylase (ogg1) enzyme repairs 8-oxo-dg adducts, suggesting that enhancing its activity in the skin might increase 8 ... | 2008 | 18086242 |
| use of stable nitrogen isotope fractionation to estimate denitrification in small constructed wetlands treating agricultural runoff. | constructed wetlands (cws) in the agricultural landscape reduce non-point source pollution through removal of nutrients and particles. the objective of this study was to evaluate if measurements of natural abundance of (15)no(3)(-) can be used to determine the fate of no(3)(-) in different types of small cws treating agricultural runoff. nitrogen removal was studied in wetland trenches filled with different filter materials (t1--sand and gravel; t3--mixture of peat, shell sand and light-weight a ... | 2008 | 18086487 |
| transoral laser microsurgery for advanced laryngeal cancer. | to report the oncologic and functional outcomes of transoral laser microsurgery (tlm) in the treatment of advanced laryngeal cancer. | 2007 | 18086960 |
| cohabitation status and onset of disability among older danes: is social participation a possible mediator? | to investigate the effect of cohabitation status in older men and women on (a) onset of disability at 3- and 4.5-year follow-up and (b) changes in functional ability between 3- and 4.5-year follow-up, and to analyze whether this effect was mediated by social participation. | 2008 | 18089766 |