| [expression of ara55 mrna in prostate carcinoma tissues and its significance]. | to investigate the expression of ara55 mrna in the prostate carcinoma tissues and its clinical significance. | 2007 | 17918707 |
| [effects of cattle encephalon glycoside and ignotin injection on serum level of s100b protein and neuron specific enolase in patients undergoing cardiac valve replacement with cardiopulmonary bypass]. | to investigate the effects of cattle encephalon glycoside and ignotin injection on serum level of s100b protein and neuron specific enolase (nse) during cardiac valve replacement with cardiopulmonary bypass (cpb). | 2007 | 17919378 |
| five year results of a randomized trial comparing hyperfractionated to conventional radiotherapy over four weeks in locally advanced head and neck cancer. | fractionation strategies delivered over 4 weeks are of clinical and radiobiological interest because treatment is completed before radiotherapy (rt) induced clonogen proliferation commences in earnest approximately 3 to 4 weeks into a course of rt. we wished to test the clinical hypothesis that an increased total dose delivered over 4 weeks with smaller than standard doses per fraction in locally advanced squamous cell carcinoma (scc) may result in relative protection of late responding tissues ... | 2007 | 17920715 |
| staging of oesophageal cancer. | diagnosis of oesophageal cancer is usually made at endoscopic biopsy. imaging is used to stage the tumour, assess response to therapy, and detect complications of therapy and recurrence. for therapy planning, differentiation of resectable (t1-t3, n0, localised n1) versus irresectable disease (t4, extensive n1, m1) is important. endoscopic ultrasound (eus) is the method of choice for diagnosing t1-t3 stages, and n0 versus n1, including endoscopic ultrasound (eus)-guided fine-needle aspiration. co ... | 2007 | 17921083 |
| interhemisphere differences during tasks involving attention and selection of lateralized stimuli. | the state of cortical activation in the parietal and temporal areas of the right and left hemispheres was evaluated using evoked potentials (ep) during tasks consisting of selection of visual stimuli lateralized in the right and left visual fields and needing three different types of attention: to stimulus shape, to stimulus position, and simultaneously to stimulus shape and position. ep were recorded in 15 young healthy experimental subjects using six cortical leads: p3, p4, t3, t4, t5, and t6; ... | 2007 | 17922246 |
| prognostic significance of altered p120 ctn expression in bladder cancer. | to identify the frequency of change in the expression and localization of p120(ctn) in bladder tumours and its association with clinical outcomes, and to investigate the potential role of p120(ctn) in the migratory and invasive behaviour of bladder carcinoma cells. | 2008 | 17922855 |
| the use of an expandable cage for corpectomy reconstruction of vertebral body tumors through a posterior extracavitary approach: a multicenter consecutive case series of prospectively followed patients. | posterior decompressions in the form of laminectomies for vertebral body tumors have poor outcomes. surgical management typically requires anterior decompression and reconstruction; however, these procedures can be associated with significant morbidity and mortality. | 2008 | 17923442 |
| subacute thyroiditis: clinical characteristics and treatment outcome in fifty-six consecutive patients diagnosed between 1999 and 2005. | to identify predictive factors of clinical outcome of subacute thyroiditis. | 2007 | 17923793 |
| severe hyponatremia due to hypopituitarism with adrenal insufficiency: a case report. | adrenal insufficiency due to hypopituitarism can lead to severe hyponatremia with potentially fatal consequences. prompt diagnosis and adequate hormonal replacement therapy are essential to block an otherwise unfavorable course and to re-establish a healthy life. unfortunately, this condition is often misdiagnosed. | 2007 | 17923801 |
| experimental antegrade enema. effects on water, electrolyte and acid-base balances with different solutions. | to study the effects on the water, electrolyte, and acid-base balances in rabbits submitted to antegrade enema with different solutions through appendicostomy. | 2007 | 17923958 |
| uterotrophic assay, hershberger assay, and subacute oral toxicity study of 4,4'-butylidenebis(2-tert-butyl-5-methylphenol) and 3-(dibutylamino)phenol, based on the oecd draft protocols. | we performed a uterotrophic assay, the hershberger assay, and a 28-day repeated-dose toxicity study [enhanced organization for economic co-operation and development (oecd) test guideline no. 407] of 4,4'-butylidenebis(2-tert-butyl-5-methylphenol) and 3-(dibutylamino)phenol, based on the oecd draft protocols. in the uterotrophic assay of 4,4'-butylidenebis(2-tert-butyl-5-methylphenol), female sd rats were subcutaneously injected with the chemical at doses of 0, 100, 300, and 1,000 mg/kg on each o ... | 2008 | 17924095 |
| [observation time for drug administration and withdrawal in the treatment of children with congenital hypothyroidism]. | to study the best observation time for drug administration and withdrawal in the treatment of children with transient congenital hypothyroidism,seeking an objective basis for the safe drug withdrawal. | 2007 | 17924470 |
| impaired iodide organification in autonomous thyroid nodules. | the clinical evolution of autonomous thyroid nodules (atn) is unpredictable, and thyrotoxicosis is observed at variable nodule size. in vitro data suggest that hydrogen peroxide production is decreased in atn, indicating intranodular iodide organification impairment. | 2007 | 17925341 |
| preoperative staging and surgical approaches for sinonasal inverted papilloma. | we sought to determine the value of preoperative staging by magnetic resonance imaging (mri) assessment in the surgical management of sinonasal inverted papillomas (ips). | 2007 | 17926590 |
| risk factors for cardiovascular disease in patients with anorexia nervosa. | hypercholesterolemia, hypercortisolemia and low levels of essential fatty acids, oestrogens and antioxidant vitamins are more prevalent in patients with anorexia nervosa (an) than in the general population. | 2007 | 17927021 |
| wt1 as a complementary marker of malignant melanoma: an immunohistochemical study of whole sections. | to test the usefulness of wt1 as a diagnostic aid in melanoma diagnosis and prognostication. | 2007 | 17927581 |
| [clinical staging of nasopharyngeal carcinoma based on mri: suggestions for improving the chinese '92 staging system]. | since the introduction of the chinese '92 staging system of nasopharyngeal carcinoma (npc), the diagnostic technology and therapeutic modality for npc have been advanced obviously over the past 15 years. this study was to evaluate the staging parameters for npc in a large cohort based on modern diagnostic and therapeutic modality to provide suggestions for improving the chinese '92 staging system. | 2007 | 17927881 |
| direct measurements of the stabilization of single-stranded dna under tension by single-stranded binding proteins. | the unzipping and rezipping of a double-stranded dna molecule is carried out in the presence of two single-stranded binding proteins t4 gp32 and e. coli ssb protein to determine the effect of the proteins on the stability of single- and double-stranded dna. the proteins do not have a significant effect on unzipping, indicating that the two proteins do not destabilize the double-stranded dna; however, both proteins inhibit rezipping. at protein concentrations where the rezipping force response is ... | 2007 | 17930074 |
| impaired serum thyrotropin response to hypothyroidism in mice with disruption of neuromedin b receptor. | neuromedin b (nb), a neuropeptide highly concentrated in pituitary, has been proposed to be an inhibitor of thyrotropin (tsh) secretion. previous study showed that mice with disruption of neuromedin b receptor (nbr-ko) have higher tsh release in response to thyrotropin-releasing hormone (trh), although tsh seems to have decreased bioactivity. here we examined in nbr-ko mice the response of tsh to thyroid hormone (th) deprivation, obtained by methimazole treatment, or excess, obtained by acute an ... | 2008 | 17931717 |
| neoadjuvant and adjuvant therapy in patients with oral squamous cell carcinoma long-term survival in a prospective, non-randomized study. | recently new concepts for the treatment of oral squamous cell carcinomas (scc) have been developed, which include preoperative simultaneous neoadjuvant radiochemotherapy (rct) and one stage operation with excision of the tumour and reconstruction. when we consider long-term survival, we find substantial evidence that combined treatment based on neoadjuvant radiochemotherapy is superior to adjuvant treatment including operation and postoperative radiation. | 2008 | 17931758 |
| high serum bile acids cause hyperthyroidism and goiter. | in the duodenal content reflux model of rats, we noted an elevation of serum bile acid and swelling of the thyroid gland. this study was designed to elucidate whether bile acids (bas) also enhance thyroid function. | 2008 | 17932765 |
| water-soluble, electroactive, and photoluminescent quaterthiophene-dinucleotide conjugates. | quaterthiophene-dinucleotide conjugates 5'ta3'-t4-3'at5', 5'aa3'-t4-3'aa5', and 5'tt3'-t4-3'tt5' (ta: thymidine-adenosine, aa: adenosine-adenosine, tt: thymidine-thymidine) were synthesized and analyzed by a combination of spectroscopy and microscopy, electrical characterization, and theoretical calculations. circular dichroism (cd) experiments demonstrated a transfer of chirality from the dinucleotides to quaterthiophene at high ionic strength and in cast films. the films were photoluminescent ... | 2008 | 17933003 |
| effects of pcbs, p,p'-ddt, p,p'-dde, hcb and beta-hch on thyroid function in preschool children. | several studies have shown that some organochlorine compounds (ocs) can interfere with the thyroid system. as thyroid hormones (ths) are essential for normal brain development, it is important to study the association between ths and ocs during pregnancy and childhood. we have evaluated the relationship between thyroid function and ocs in preschool children. | 2008 | 17933884 |
| effect of 30 mci radioiodine on multinodular goiter previously treated with recombinant human thyroid-stimulating hormone. | recombinant human thyroid-stimulating hormone (rhtsh) enhances 131i uptake, permitting a decrease in radiation for the treatment of multinodular goiter (mng). our objective was to evaluate the safety and efficacy of a single 0.1-mg dose of rhtsh, followed by 30 mci 131i, in patients with mng. seventeen patients (15 females, 59.0 +/- 13.1 years), who had never been submitted to 131i therapy, received a single 0.1-mg injection of rhtsh followed by 30 mci 131i on the next day. mean basal thyroid vo ... | 2007 | 17934635 |
| differences in spatial-temporal parameters and arm-leg coordination in butterfly stroke as a function of race pace, skill and gender. | spatial-temporal parameters (velocity, stroke rate, stroke length) and arm-leg coordination in the butterfly stroke were studied as a function of race pace, skill (due to technical level, age, and experience) and gender. forty swimmers (ten elite men, ten elite women, ten less-skilled men, and ten less-skilled women) performed the butterfly stroke at four velocities corresponding to the appropriate paces for the 400-m, 200-m, 100-m, and 50-m, respectively. arm and leg stroke phases were identifi ... | 2008 | 17935810 |
| strand-specific contacts and divalent metal ion regulate double-strand break formation by the giy-yig homing endonuclease i-bmoi. | giy-yig homing endonucleases are modular enzymes consisting of a well-defined n-terminal catalytic domain connected to a variable c-terminal dna-binding domain. previous studies have revealed that the role of the dna-binding domain is to recognize and bind intronless dna substrate, positioning the n-terminal catalytic domain such that it is poised to generate a staggered double-strand break by an unknown mechanism. interactions of the n-terminal catalytic domain with intronless substrate are the ... | 2007 | 17936302 |
| simultaneous quantification of free triiodothyronine and free thyroxine by isotope dilution tandem mass spectrometry. | this study was designed to improve our previously developed tandem mass spectrometry (ms/ms) method for free thyroxine (ft4) by enhancing sensitivity and permitting simultaneous measurements of both free triidothyronine (ft3) and ft4 using a smaller plasma/serum sample. | 2007 | 17936741 |
| serum t3 and t4 concentrations in lambs with nutritional myodegeneration. | selenium (se) deficiency is an important etiological factor in nutritional myodegeneration disease (nmd) of lambs, and se is required for synthesis of thyroid hormones. | 2007 | 17939578 |
| a hexanucleotide sequence (dc1-dc6 tract) restricts the dc-specific cleavage of single-stranded dna by endonuclease iv of bacteriophage t4. | endonuclease (endo) iv encoded by denb of bacteriophage t4 is an enzyme that cleaves single-stranded (ss) dna in a dc-specific manner. previously we have demonstrated that a dtdcda is most preferable for endo iv when an oligonucleotide substrate having a single dc residue is used. here we demonstrate that endo iv cleaves ssdnas exclusively at the 5'-proximal dc where a sequence comprises dc residues both at the 5' proximal and 3' proximal positions (a dcs tract-dependent cleavage). the dcs tract ... | 2007 | 17940096 |
| effect of the number of concentrate feeding places per pen on performance, behavior, and welfare indicators of friesian calves during the first month after arrival at the feedlot. | seventy-two friesian calves (bw = 102.0 +/- 1.8 kg) were bought from a commercial calf farm and distributed to a factorial arrangement of treatments in a complete block design with 3 treatments and 3 blocks of similar fasted bw to study the effect of increasing the number of feeding places per pen on performance, behavior, and welfare indicators during the 4 wk after arrival. treatments consisted of 1 (t1), 2 (t2), or 4 (t4) concentrate feeding places/pen (8 calves/pen). concentrate and straw we ... | 2008 | 17940151 |
| [a case of stage iv non-operated advanced breast cancer with local recurrence thirteen years after initial therapy]. | a 73-year-old woman underwent chemotherapy, radiotherapy, and hormonal therapies for right advanced breast cancer (t4, n3, m1, stage iv) in 1993. she obtained a complete response in pathological evaluation (pcr) in 1998. for adjuvant therapies, she had been treated with hormonal therapies for five years until 2003. after the interruption of hormonal therapies, the serum levels of tumor markers had been elevated, and she had a right axillary local recurrence and a right ovarian metastasis detecte ... | 2007 | 17940393 |
| insights from molecular pathways: potential pharmacologic targets of benign thyroid nodules. | to describe molecular pathways that might be of relevance for a potential pharmacologic therapy of benign thyroid nodules. | 2007 | 17940470 |
| thyroid hormones affect the level and activity of nitric oxide synthase in rat cerebral cortex during postnatal development. | the effects of thyroid hormones (th) on the enzyme level and activity of neuronal nitric oxide synthase (nnos) were studied in the rat cerebral cortex during postnatal life. as revealed by arginine/citrulline conversion assay and western blot analysis of the homogenate of the parietal cortex t4 significantly increased nnos activity and nnos protein level to 153 +/- 25% and to 178 +/- 20%, respectively. in contrast, 6-n-propyl-2-thyouracil (ptu) decreased nnos activity and nnos level to 45 +/- 10 ... | 2008 | 17940896 |
| rna involvement in t4 dna synthesis in toluene-treated cells. | in t4-infected cells made permeable with toluene, pulses with [(alpha-32p deoxyribonucleoside triphosphates demonstrated covalent linkage of rna to dna of the okazaki fragments. analysis of the transfer of the 32p label to the 2'(3') ribonucleoside monophosphates indicated that the 3'-end of the rna primer is heterogeneous. the most frequently encountered ribonucleotide was rcmp, but also transfer to rump, ramp and rgmp occurred at different frequencies. in contrast, no heterogeneity was observe ... | 1980 | 17941178 |
| association between serum tsh, free t4 and serum liver enzyme activities in a large cohort of unselected outpatients. | although overt thyroid dysfunction is associated with some liver abnormalities, there is a dearth of information on liver function tests across thyroid function tests. we assessed the relationship between serum liver enzyme activity and thyroid function tests in a cohort of adult individuals. | 2008 | 17941901 |
| single phage t4 dna packaging motors exhibit large force generation, high velocity, and dynamic variability. | terminase enzyme complexes, which facilitate atp-driven dna packaging in phages and in many eukaryotic viruses, constitute a wide and potentially diverse family of molecular motors about which little dynamic or mechanistic information is available. here we report optical tweezers measurements of single dna molecule packaging dynamics in phage t4, a large, tailed escherichia coli virus that is an important model system in molecular biology. we show that a complex is formed between the empty prohe ... | 2007 | 17942694 |
| tilapia larvae aroclor 1254 exposure: effects on gonads and circulating thyroid hormones during adulthood. | aroclor 1254 a polychlorinated biphenyls (pcbs) mixture, when administrated through the diet, was previously found to inhibit adult tilapia (oreochromis niloticus) reproduction. since fish larvae can be more sensitive to contaminants, the objectives of this study were to evaluate in adults the impact in gonad development and in thyroid function of aroclor 1254 administrated at larvae stages. aroclor 1254 exposed tilapia presented both ovary and testicular alterations and a decline in t4 plasma c ... | 2007 | 17943219 |
| intermittent versus continuous androgen suppression for prostatic cancer. | after lung cancer, prostate cancer is the most common cause of death among males. the aim of treatment is to prevent disease-related morbidity and mortality while minimizing intervention-related adverse events. androgen suppression therapy (ast) to reduce circulating serum testosterone and disease progression is considered a mainstay of treatment for men with advanced prostate cancer. it has been increasingly utilized for early stage disease despite a lack of evidence of effectiveness. | 2007 | 17943832 |
| influence of autonomic impairment on blood-pressure and heart-rate scaling structures. | self similarity is a promising tool for quantifying alterations in cardiovascular dynamics, although the effect of the autonomic control on the scaling structure of cardiovascular signals is still unknown. to address this issue, we studied spinal-cord injured subjects as a model of progressively impaired vascular control. we considered 24 able-bodied subjects (ab) and 23 paraplegics with lesion at different levels: between t12 and l4 (n=7); t5 and t11 (n=9); and c6 and t4 (n=7). we recorded bloo ... | 2006 | 17946047 |
| design of mechanism-based inhibitors of transthyretin amyloidosis: studies with biphenyl ethers and new structural templates. | transthyretin (ttr), a tetrameric thyroxine (t4) carrier protein, is associated with a variety of amyloid diseases. in this study, we explore the potential of biphenyl ethers (bpe), which are shown to interact with a high affinity to its t4 binding site thereby preventing its aggregation and fibrillogenesis. they prevent fibrillogenesis by stabilizing the tetrameric ground state of transthyretin. additionally, we identify two new structural templates (2-(5-mercapto-[1,3,4]oxadiazol-2-yl)-phenol ... | 2007 | 17948976 |
| mapping electron paramagnetic resonance spin label conformations by the simulated scaling method. | in order to efficiently simulate spin label behavior when attached to the protein backbone we developed a novel approach that enhances local conformational sampling. the simulated scaling (ss) approach (li, h., et al. j. chem. phys. 2007, 126, 24106) couples the random walk of a potential scaling parameter and molecular dynamics in the framework of hybrid monte carlo. this approach allows efficient barrier crossings between conformations. the method retains the thermodynamic detailed balance all ... | 2007 | 17948993 |
| theoretical study of the structure and properties of na-mor and h-mor zeolite models. | this work presents calculated structural parameters and energetic properties of na- and h-mordenites (mors) using cluster models with more than 400 atoms. these state of the art calculations were performed within the framework of density functional theory, using both the local density approximation and the generalized gradient approximation, employing all-electron basis sets. the most populated t3, t4, and t1 al sites have been investigated using two different mor models, each containing two iso ... | 2007 | 17949194 |
| the involvement of thyroid hormones and cortisol in the osmotic acclimation of solea senegalensis. | the peripheral conversion of the prohormone 3,5,3',5'-tetraiodothyronine (t4) to the biologically active 3,5,3'-triiodothyronine (t3), via enzymatic deiodination by deiodinases, is an important pathway in thyroid hormone metabolism. the aim of this study was to test if thyroid hormones and cortisol, as well as the outer ring deiodination (ord) metabolic pathway, are involved in the osmoregulatory response of senegalese sole (solea senegalensis, kaup 1858). we measured osmoregulatory and endocrin ... | 2008 | 17950731 |
| polychlorinated biphenyl effects on avian hepatic enzyme induction and thyroid function. | polychlorinated biphenyls (pcbs) decrease thyroid function in laboratory rodents by inducing activity of a liver enzyme, uridine diphosphate-glucuronosyltransferase (udp-gt), thereby increasing thyroxine (t4) clearance. this loss of t4 can lead to hypothyroidism. in this study, an assay was validated for measuring udp-gt activity toward t4 in japanese quail. udp-gt induction by aroclor 1254 was evaluated in quail, and responses of quail and mice were compared. in experiment 1, japanese quail and ... | 2008 | 17950733 |
| cdna cloning and expression analysis of thyroid hormone receptor in the coho salmon oncorhynchus kisutch during smoltification. | two types of cdna clones encoding thyroid hormone receptor (tr) genes, tralpha and trbeta, were isolated from the coho salmon oncorhynchus kisutch. the two genes each consists of multiple isoforms, derived from different loci or by an alternative splicing. rt-pcr revealed a broad localization of the tralpha and trbeta transcripts that both expressed in brain, gill, liver, muscle, kidney, ovary, skin and eyeball. during the early stages of the smoltification period, the mrna level of the tr trans ... | 2008 | 17950735 |
| a possible method using baseline hormonal levels to prescribe the appropriate oral therapeutic radioiodine dosage for graves' disease. | the purpose of this study was to retrospectively examine the correlations of hormonal ratios with radioiodine i-131 therapeutic parameters and the potentiality of prescribing the therapeutic i-131 target dosage for an individual patient with graves' disease using baseline serum levels of thyroid hormones. | 2007 | 17952556 |
| [high-dose cef (cyclophosphamide, epirubicin, fluorouracil) as primary chemotherapy in locally advanced breast cancer: long-term results]. | to determine wether primary cef is effective in locally advanced breast cancer, as measured by response, local recurrences, disease free survival (dfs) and overall survival (os). | 2007 | 17953285 |
| [expressions of hypoxia inducible factor-1alpha and insulin-like growth factor-ii in gastric carcinoma: correlation with angiogenesis and prognosis]. | to investigate relationship between expressions of hypoxia inducible factor-1alpha (hif-1alpha) and insulin-like growth factor-ii (igf-ii) as well as their correlation with angiogenesis and prognosis in gastric carcinoma. | 2007 | 17953839 |
| outcomes after extrapleural pneumonectomy and intensity-modulated radiation therapy for malignant pleural mesothelioma. | malignant pleural mesothelioma is a locally aggressive tumor that is usually fatal. extrapleural pneumonectomy (epp) followed by hemithoracic irradiation has shown promise, but local failure remains a significant problem. to improve local control, we have used intensity-modulated radiation therapy (imrt) as it allows better dose distribution to regions at risk of recurrence as well as reduced radiation to surrounding organs. | 2007 | 17954086 |
| serum thyrotropin in graves' disease: a more reliable index of circulating thyroid-stimulating immunoglobulin level than thyroid function? | to assess the relationship between serum thyrotropin (thyroid-stimulating hormone or tsh) on one hand and thyroid-stimulating immunoglobulin (tsi), free thyroxine (t4), and triiodothyronine (t3) levels on the other in graves' disease, inasmuch as tsh may be suppressed in the presence of tsi because tsi may bind to the tsh receptor on the thyroid gland membrane and thus eliminate the need for circulating tsh for stimulating the thyroid gland. | 2007 | 17954417 |
| evolution of the epidemiology and clinical characteristics of larynx and hypopharynx carcinoma in poland from 1991 to 2001. | a retrospective analysis was performed of 12,888 cases of larynx and hypopharynx carcinoma diagnosed in 19 ent departments in poland during an 11-year period from 1991 to 2001. an assessment of basic epidemiological data, including also tumor site and disease stage at the time of diagnosis, was conducted. epidemiological trends over the 11-year period of the analysis were examined. the average m:f proportion was 8:1, with a significant increase in the number of female patients during the analyze ... | 2008 | 17955255 |
| activity of glycosidases (beta-n-acetyloglucosaminidase, alpha-mannosidase, and beta-galactosidase) in the uterine luminal fluid of cows after multiple ovulation. | this study investigated the activity of beta-n-acetyloglucosaminidase (beta-nagase), alpha-mannosidase, and beta-galactosidase in the uterine luminal fluid of cows after superovulation treatment, along with the possible associations between the activity of these 3 glycosidases and the superovulatory response. embryos and a sample of fluid flushed from each uterine horn were collected on day 7 after artificial insemination (on estrus day 0) from 32 cows in which superovulation was induced with po ... | 2007 | 17955905 |
| isotretinoin as a diagnostic tool for localization of thyroid tissue in a thyroid cancer patient: a case report. | the ability of thyroid cancer to incorporate radioiodine and to produce thyroglobulin (tg) is an important tool for the diagnosis of tumor relapse. however, some patients show high serum tg and negative whole body scan (wbs) since some specific thyroid properties may be lost during tumor progression. in these cases, a more careful diagnostic approach is necessary. here, we report the case of a patient with undetectable serum tg under levothyroxine (l-t4)-suppressive therapy and with a negative w ... | 2007 | 17956163 |
| molecular characterization, gene expression and dependence on thyroid hormones of two type i keratin genes (sseker1 and sseker2) in the flatfish senegalese sole (solea senegalensis kaup). | keratins make up the largest subgroup of intermediate filaments, and, in chordates, represent the most abundant proteins in epithelial cells. they have been associated with a wide range of functions in the cell, but little information is still available about their expression profile and regulation during flatfish metamorphosis. senegalese sole (solea senegalensis) is a commercially important flatfish in which no keratin gene has been described yet. | 2007 | 17956602 |
| treatment outcome of graves' disease in thai children. | graves' disease is the most common cause of thyrotoxicosis in children. treatment of graves' disease consists of anti-thyroid drugs, radioactive iodide and thyroidectomy but the optimal treatment of gd in children is still controversial. | 2007 | 17957924 |
| naturally occurring bacteriophages lyse a large proportion of canine and feline uropathogenic escherichia coli isolates in vitro. | we investigated the feasibility of bacteriophage therapy to combat canine and feline escherichia coli urinary tract infections (utis) by testing the in vitro lytic ability of 40 naturally occurring bacteriophages on 53 uropathogenic e. coli (upec). the mean number of upec strains lysed by an individual bacteriophage was 21/53 (40%, range 17-72%). in total, 50/53 (94%) of the upec strains were killed by one or more of the bacteriophages. ten bacteriophages lysed 51% of upec strains individually a ... | 2008 | 17959211 |
| relation between serum thyroid hormone and 'nondipper' circadian blood pressure variability. | currently, the pathogenesis of nondipper hypertension remains largely unclear in patients without any renal or endocrine pathology. it is well known that overt hypothyroidism is strongly associated with diastolic hypertension. however, no study has addressed the pathogenic role of tsh, free t3 (ft3), and free t4 (ft4) in nondipper hypertension. the aim of the present investigation is to evaluate if higher tsh, low ft3 and ft4 would be associated with a nondipper hypertension profile, in patients ... | 2007 | 17960070 |
| sinonasal adenoid cystic carcinoma: the m. d. anderson cancer center experience. | adenoid cystic carcinoma of the sinonasal tract is a rare cancer that accounts for 10% of all malignancies at this site. the objective of the current study was to evaluate prognostic factors, treatment outcomes, recurrence patterns, and survival rates for sinonasal adenoid cystic carcinoma. | 2007 | 17960615 |
| survival improvements for advanced stage nonbronchioloalveolar carcinoma-type nonsmall cell lung cancer cases with ipsilateral intrapulmonary nodules. | survival improvements have been demonstrated for patients with bronchioloalveolar (bac) nonsmall cell lung cancer (nsclc) with intrapulmonary satellite t4 nodules compared with other patients with stage iiib disease, and for ipsilateral intrapulmonary m1 tumors versus contralateral or distant metastasis. however, it is not known whether these differences are observed in patients with non-bac nsclc. | 2008 | 17960795 |
| iodine supplementation during pregnancy: a public health challenge. | iodine deficiency remains the most frequent cause worldwide, after starvation, of preventable mental retardation in children. it causes maternal hypothyroxinemia, which affects pregnant women even in apparently iodine-sufficient areas, and often goes unnoticed because l-thyroxine (t4) levels remain within the normal range, and thyroid-stimulating hormone (tsh) is not increased. even a mild hypothyroxinemia during pregnancy increases the risk of neurodevelopmental abnormalities, and experimental ... | 2007 | 17962037 |
| structural rearrangements near the chromophore influence the maturation speed and brightness of dsred variants. | the red fluorescent protein dsred has been extensively engineered for use as an in vivo research tool. in fast maturing dsred variants, the chromophore maturation half-time is approximately 40 min, compared to approximately 12 h for wild-type dsred. further, dsred has been converted from a tetramer into a monomer, a task that entailed mutating approximately 20% of the amino acids. these engineered variants of dsred have proven extremely valuable for biomedical research, but the structural basis ... | 2007 | 17962222 |
| stability of the hard and soft tissue profile after mandibular advancement in sagittal split osteotomies: a longitudinal and long-term follow-up study. | the aim of the study was to conduct a long-term follow-up investigation of the stability of hard and soft tissues after bilateral sagittal split osteotomy (bsso) with rigid internal (rif) fixation to advance the mandible. sixteen consecutive patients (12 females and 4 males, mean age 21.4 years) were available for re-examination 12.7 years (t5) after surgery. the preceding follow-ups were before (t1), and 5 days (t2), 7.3 months (t3), and 13.9 months (t4) after surgery. lateral cephalograms were ... | 2008 | 17962316 |
| gpcr engineering yields high-resolution structural insights into beta2-adrenergic receptor function. | the beta2-adrenergic receptor (beta2ar) is a well-studied prototype for heterotrimeric guanine nucleotide-binding protein (g protein)-coupled receptors (gpcrs) that respond to diffusible hormones and neurotransmitters. to overcome the structural flexibility of the beta2ar and to facilitate its crystallization, we engineered a beta2ar fusion protein in which t4 lysozyme (t4l) replaces most of the third intracellular loop of the gpcr ("beta2ar-t4l") and showed that this protein retains near-native ... | 2007 | 17962519 |
| high-resolution crystal structure of an engineered human beta2-adrenergic g protein-coupled receptor. | heterotrimeric guanine nucleotide-binding protein (g protein)-coupled receptors constitute the largest family of eukaryotic signal transduction proteins that communicate across the membrane. we report the crystal structure of a human beta2-adrenergic receptor-t4 lysozyme fusion protein bound to the partial inverse agonist carazolol at 2.4 angstrom resolution. the structure provides a high-resolution view of a human g protein-coupled receptor bound to a diffusible ligand. ligand-binding site acce ... | 2007 | 17962520 |
| squamous cell carcinoma of the nasal columella: a retrospective study of 66 cases from the gettec. | squamous cell carcinoma of the nasal columella (sccnc) is a rare disease. we aimed to define a strategy for the diagnosis and management of nasal columella squamous cell carcinoma. medical records of 66 patients presenting with columella squamous cell carcinoma in nine french hospitals, from 1980 to 2003, were evaluated to determine the clinical characteristics and current treatment of the disease. mean age was 69 years. the sex ratio was one female for three males. majority of the lesions were ... | 2008 | 17962969 |
| parallel fabrication of rna microarrays by mechanical transfer from a dna master. | a new method for fabrication of rna microarrays is described. the approach involves cohybridization of a short, biotinylated dna oligonucleotide and an rna probe sequence to dna templates spotted onto a master array. next, the short dna sequence and the rna probe are linked using a t4 dna ligase. finally, a poly(dimethylsiloxane) (pdms) monolith modified on the surface with streptavidin is brought into conformal contact with the master array. this results in binding of the biotinylated dna/rna o ... | 2007 | 17963362 |
| developmental exposure to low-dose pbde-99: tissue distribution and thyroid hormone levels. | thyroid hormone concentrations, hepatic enzyme activities and tissue concentrations of 2,2',4,4',5-pentabromodiphenyl ether (pbde-99) were evaluated in wistar rats (dams and offspring) after treatment by gavage on gestation day (gd) 6 with a single low dose of either 60 or 300 microg pbde-99/kg body weight (bw), respectively. tissue concentration analysis confirmed that pbde-99 is persistent in rodents as significant amounts of the parent compound were detected in adipose tissue 37 days after ex ... | 2007 | 17964054 |
| quantifying dna-protein interactions by single molecule stretching. | in this chapter, we discuss a new method for quantifying dna-protein interactions. a single double-stranded dna (dsdna) molecule is stretched beyond its contour length, causing the base pairs to break while increasing the length from that of dsdna to that of ssdna. when applied in a solution containing dna binding ligands, this method of force-induced dna melting can be used to quantify the free energy of ligand binding, including the free energy of protein binding. the dependence of melting for ... | 2008 | 17964942 |
| effect of methimazole-induced hypothyroidism on adrenal and gonadal functions in male japanese quail (coturnix japonica). | to investigate the effect of hypothyroidism on gonadal and adrenal functions in male japanese quail (coturnix japonica), hypothyroidism was induced in male adult japanese quail by daily administration of 2-mercapto-1-methylimidazole (methimazole) in their drinking water. four weeks after methimazole treatment, the japanese quail were sacrificed, and the plasma concentrations of free triiodothyronine (ft3), free thyroxine (ft4), total t3 (tt3), total t4 (tt4), corticosterone, testosterone, lh and ... | 2007 | 17965543 |
| [concurrent chemoradiotherapy for squamous cell carcinoma of the oropharynx]. | subjects were 34 patients, 32 men and 2 women, with squamous cell carcinoma of the oropharynx, with a median age of 63 years (range, 47 to 72 year). subsites were the lateral wall in 18, anterior wall in 10, posterior wall in 5 and superior wall in 1. nine had stage iii disease and 25 had stage iv disease. nineteen cases were resectable and 15 cases were unresectable. the patients were treated with concurrent chemoradiotherapy. the treatment regimen consisted of 5-fluorouracil (5-fu) and cisplat ... | 2007 | 17966498 |
| [clinical and histological latero-cervical nodal metastases in squamous oropharyngeal carcinoma]. | the goal of our study was to estimate the presence (or absence) of latero-cervical nodal metastases (pn+), in patients with squamous oropharyngeal cancer, correlating this finding with t stage. we examined 255 patients out of 329 affected by squamous oropharyngeal cancer, from 1976 to 2005. the 255 patients examined were treated surgically (both t and n). as far as clinical latero-cervical nodal metastases were concerned, 215 patients (84%) were cn+, while 40% (16%) were cn-. the result of the h ... | 2007 | 17966770 |
| evaluation of breast sentinel lymph node coverage by standard radiation therapy fields. | biopsy of the breast sentinel lymph node (sln) is now a standard staging procedure for early-stage invasive breast cancer. the anatomic location of the breast sln and its relationship to standard radiation fields has not been described. | 2008 | 17967511 |
| comparative outcome between chemoradiotherapy and lateral pelvic lymph node dissection following total mesorectal excision in rectal cancer. | to evaluate comparative outcome between adjuvant postoperative chemoradiotherapy (postoperative crt) and lateral pelvic lymph node dissection (lpld) following total mesorectal excision (tme) in rectal cancer patients. | 2007 | 17968166 |
| heritability of serum tsh, free t4 and free t3 concentrations: a study of a large uk twin cohort. | thyroid hormone action influences many metabolic and synthetic processes, but the degree of regulation attributed to genes and environmental factors affecting normal variation remains controversial. | 2008 | 17970774 |
| enzymatic manipulations of dna oligonucleotides on microgel: towards development of dna-microgel bioassays. | we demonstrate that dna oligonucleotides covalently coupled to colloidal microgel can be manipulated by t4 dna ligase for dna ligation and by phi29 dna polymerase for rolling circle amplification (rca). we also show that the long single-stranded rca product can generate intensive fluorescence upon hybridization with complementary fluorescent dna probe. we believe dna-microgel conjugates can be explored for the development of dna based bioassays and biosensors. | 2007 | 17971955 |
| optimization of non-natural nucleotides for selective incorporation opposite damaged dna. | the promutagenic process known as translesion dna synthesis reflects the ability of a dna polymerase to misinsert a nucleotide opposite a damaged dna template. to study the underlying mechanism of nucleotide selection during this process, we quantified the incorporation of various non-natural nucleotide analogs opposite an abasic site, a non-templating dna lesion. our kinetic studies using the bacteriophage t4 dna polymerase reveal that the pi-electron surface area of the incoming nucleotide sub ... | 2007 | 17971991 |
| chronic leptin treatment inhibits liver mitochondrial alpha-glycerol-beta-phosphate dehydrogenase in euthyroid rats. | leptin modulates the hypothalamus-pituitary-thyroid axis and peripheral metabolism of thyroid hormones (ths). we have studied the effect of acute and chronic leptin treatment upon liver mitochondrial glycerol phosphate dehydrogenase activity (mgpd), whose expression and activity are th dependent. we performed 2 experiments: 1) acute leptin treatment - lepa: adult rats received a single leptin injection (8 microg/100 g bw); 2) chronic leptin treatment - lepc: adult rats received leptin (8 microg/ ... | 2007 | 17973206 |
| [correlation of cytology and scintigraphic findings in thyroid gland diseases pathohistologically diagnosed]. | we compared cytologic and scintigraphic findings with pathohistologic diagnosis in 60 patients (11 males and 49 females) with nodular goiter. in the preoperative period, apart from clinical examination, all patients underwet thyroid gland scyntigraphy, puncture, t3, t4, tsh hormon test, and if clinically relevant, thyroglobulin. on the basis of pathohistologic diagnosis, two groups were formed: nontumour and tumour lesions. the nontumour lesion gruop consisted of 24 colloid and 8 cystic noduli. ... | 1994 | 17974411 |
| [combined radio-chemotherapy in solid tumour treatment of advanced bladder cancer (preliminary report)]. | radiotherapy combined with platinum compounds in widely used despite unclear biological basis and mechanism of their potentiation. we started a prospective nonrandom study on january 1, 1991 with the aim to ameliorate local tumour control and possibility of curative treatment, and treatment of toxicyty. patients characteristics: 82 patients with locally advanced bladder cancer (stage t3 and localizet t4) were treated with radiochemotherapy. median age was 62 years, and male female radio was 3.5: ... | 1994 | 17974413 |
| sebaceous carcinoma of the eyelids: a review of 21 cases. | sebaceous carcinoma is a malignant neoplasm that arises from the sebaceous glands and occurs most often in the eyelids. a tumour diameter exceeding 10mm indicates a grave prognosis. however, thus far, no study has used the t classification of the tumour, node, metastasis (tnm) staging system to determine the prognosis. in this article, we studied the management and outcomes of sebaceous carcinoma using the t classification. | 2008 | 17974515 |
| a finite element framework for computation of protein normal modes and mechanical response. | a computational framework based on the finite element method is presented to calculate the normal modes and mechanical response of proteins and their supramolecular assemblies. motivated by elastic network models, proteins are treated as continuum elastic solids with molecular volume defined by their solvent-excluded surface. the discretized finite element representation is obtained using a surface simplification algorithm that facilitates the generation of models of arbitrary prescribed spatial ... | 2008 | 17975833 |
| differential methylation kinetics of individual target site strands by t4dam dna methyltransferase. | prokaryote dna methyltransferases (mtases) of the dam family (including those of bacteriophages t2 and t4) catalyze methyl group transfer from s-adenosyl-l-methionine (adomet), producing s-adenosyl-l-homocysteine (adohcy) and methylated adenine residues in palindromic gatc sequences. dam dna mtases, as all site-specific enzymes interacting with polymeric dna, require a mechanism of action that ensures a rapid search for specific targets for catalytic action, during both the initial and subsequen ... | 2007 | 17976013 |
| [effects of amiodarone on the thyroid gland: appearance of microlesions in follicles of hyperplastic rat thyroid after chronic amiodarone treatment]. | using the rat and guinea-pig as an experimental animal model, the effect of amiodarone (cordarone) on normal of hyperplastic thyroid was investigated in eu- or hypothyroid animals. following short- or long-term treatments with different doses of amiodarone (5-50 mg/day) and amiodarone-equivalent amounts of stable iodine, serum thyroid hormones were assayed, followed by determination of thyroid uptake of radioiodine, the weight of the thyroid gland and its histological structure. having received ... | 1994 | 17977412 |
| the thyroid gland and thyroid hormones in senegalese sole (solea senegalensis) during early development and metamorphosis. | we here describe the ontogeny and morphology of the thyroid gland in senegalese sole (solea senegalensis), and correlate these with whole body concentrations of thyroid hormones during early development and metamorphosis. under our rearing conditions at 19.5 degrees c, most larvae entered metamorphosis in stage 1 at 15 days post-hatching (dph), and completed metamorphosis in stage 4 at 25dph. the onset of metamorphosis coincided with surges in whole body t4 and t3 concentrations. crossmon's tric ... | 2008 | 17977536 |
| accurate prediction of enzyme mutant activity based on a multibody statistical potential. | an important area of research in biochemistry and molecular biology focuses on characterization of enzyme mutants. however, synthesis and analysis of experimental mutants is time consuming and expensive. we describe a machine-learning approach for inferring the activity levels of all unexplored single point mutants of an enzyme, based on a training set of such mutants with experimentally measured activity. | 2007 | 17977887 |
| detection of four adenovirus serotypes within water-isolated strains of acanthamoeba in the canary islands, spain. | we surveyed 236 potentially pathogenic acanthamoeba strains, isolated from water sources in the canary islands, for the presence of human adenoviruses (hadv) using a polymerase chain reaction (pcr)-based typing assay. a total of 34 of these strains were found to be positive for adenovirus belonging to four different hadv serotypes (hadv-1, 2, 8, and 37). we found that hadv-2 was the most frequently encountered serotype amongst the acanthamoeba strains, and their identification was confirmed by a ... | 2007 | 17978083 |
| traction versus supine side-bending radiographs in determining flexibility: what factors influence these techniques? | prospective clinical, radiologic study of adolescent idiopathic scoliosis (ais). | 2007 | 17978661 |
| factors related to survival from oral cancer in an andalusian population sample (spain). | approximately 3% of malignant tumors originate in the oral cavity. the majority are squamous cell carcinomas, and a small percentage, malignant tumors of the salivary glands, lymphoreticular diseases, bone tumors, melanomas, sarcomas, malignant odontogenic tumors and metastases of tumors from other locations. the prognosis of these pathologies depends on the size, infiltration, and site of the lesion, the presence or absence of metastatic spread, and to a certain degree the differentiation of th ... | 2007 | 17978776 |
| prediction of hypothyroidism after hemithyroidectomy: a biochemical and pathological analysis. | the possibility of postsurgical hypothyroidism after hemithyroidectomy is no longer a new subject. although many previous studies have mentioned posthemithyroidectomy hypothyroidism, the incidence and contributing factors for hypothyroidism remain uncertain. we intended to evaluate the incidence and the time of development of hypothyroidism after hemithyroidectomy and to analyze the relationship of posthemithyroidectomy hypothyroidism with preoperative biochemical parameters and postoperative hi ... | 2008 | 17978827 |
| survival prognostic factors for lateral bucco-pharyngeal junction squamous cell carcinoma. | squamous cell carcinomas (scc) localized at the lateral buccopharyngeal junction are frequent occurrences in our experience. this anatomical site gives the tumor ample space to spread in different directions, making tumor management all the more difficult. we focused our study on this localization to underline their specificities and evaluate our practices. in the department of head and neck oncology at the centre oscar lambret, 57 patients with lateral bucco-pharyngeal junction scc were treated ... | 2008 | 17978830 |
| enantiorecognition of triiodothyronine and thyroxine enantiomers using different chiral selectors by hplc and micro-hplc. | this paper deals with the chiral separation of triiodothyronine (t3) and thyroxine (t4) by hplc and micro-hplc. the separation of t3 and t4 is of great pharmaceutical and clinical interest, since the enantiomers exhibit different pharmacological activities. the hplc measurements were performed on a chiral stationary ligand-exchange phase using l-4-hydroxyproline bonded via 3-glycidoxypropyltrimethoxysilane to silica gel as a selector. also a chiral teicoplanin (chirobiotic) phase was used. in mi ... | 2008 | 17980436 |
| role of adjuvant chemoradiation therapy in adenocarcinomas of the ampulla of vater. | the role of adjuvant chemoradiation therapy (crt) in the treatment of ampullary cancers remains undefined. we retrospectively compared treatment outcomes in patients treated with pancreaticoduodenectomy alone versus those who received additional adjuvant crt. | 2008 | 17980502 |
| effects of sub-chronic nitrate exposure on the thyroidal function in humans. | no experimental data exist on the thyroid toxicity of nitrate among humans. we aimed to show that no significant antithyroid effect could be observed after exposure to a three times the acceptable daily intake of nitrate in humans. in a randomized controlled non-inferiority trial, 10 volunteers received 15 mg/kg sodium nitrate during 28 days whereas 10 control participants received distilled water. we performed 5- and 24-h measurements of thyroidal (131)i uptake (raiu) before and at the end of t ... | 2007 | 17980977 |
| thyroid disease in patients with mccune-albright syndrome. | involvement of the thyroid gland in the mccune-albright syndrome (mas) is a common and sometimes overlooked feature of this disorder. the characteristics of the thyroid in mas include isolated or combinations of generalized inhomogeneity, cystic and/or nodular features coupled with functional abnormalities. while most often the pathology is diffuse, it is rarely associated with compressive symptoms and signs. the functional abnormalities, which are seldom observed in the absence of underlying ec ... | 2007 | 17982391 |
| 18f-fdg dual-headed gamma camera pet in detection of axillary nodal disease in patients with large or locally advanced breast cancer: possible alternative staging of axilla. | positron emission tomography (pet) has been used in staging the axilla. gamma camera pet (gcpet) is a cost effective alternative, but poorly studied. the aim of this study was to assess gcpet in demonstrating metastatic deposits in axillary nodes in patients with a high likelihood of nodal disease. twenty-seven women with large (t2, t3 or t4) or advanced breast cancer (n1, n2 or m1) were recruited. all patients underwent axillary lymph node removal or biopsy (fine needle aspiration cytology (fna ... | 2007 | 17982642 |
| enhancing the "a-rule" of translesion dna synthesis: promutagenic dna synthesis using modified nucleoside triphosphates. | abasic sites are mutagenic dna lesions formed as a consequence of inappropriate modifications to the functional groups present on purines and pyrimidines. in this paper we quantify the ability of the high-fidelity bacteriophage t4 dna polymerase to incorporate various promutagenic alkylated nucleotides opposite and beyond this class of non-instructional dna lesions. kinetic analyses reveal that modified nucleotides such as n6-methyl-datp and o6-methyl-dgtp are incorporated opposite an abasic sit ... | 2007 | 17983244 |
| multifocal t4 non-small cell lung cancer: a subset with improved prognosis. | t4-disease for non-small cell lung cancer (nsclc) includes different conditions: mediastinal invasion, neoplastic pleural cytology, and multifocal disease in the same lobe; regarding the last category, no strict criteria allow to differentiate satellite nodules from synchronous multiple primary tumours. | 2008 | 17983760 |
| expression of er, pgr, her1, her2, and response: a study of preoperative chemotherapy. | to identify the role of estrogen (er), progesterone (pgr), epidermal growth factor 1 (her1), and her2 receptors in predicting response to preoperative chemotherapy. | 2008 | 17986623 |
| technique and clinical results of minimally invasive reconstruction and stabilization of the thoracic and thoracolumbar spine with expandable cages and ventrolateral plate fixation. | to evaluate the techniques of minimally invasive single- and multilevel corpectomy and reconstruction of the thoracic and thoracolumbar spine using expandable vertebral body replacement (vbr) cages and ventrolateral plate fixation (vpf) via anterolateral retropleural (alra) and combined thoracoabdominal approaches. | 2007 | 17986942 |
| thyroxine therapy in euthyroid patients does not affect body composition or muscular function. | the main objective of the study was to evaluate the effects of small increments in thyroxine (t4) levels following levothyroxine (l-t4) administration on the body composition of women patients. the secondary objective was to assess the effect of the therapy on energy expenditure and muscular function. | 2008 | 17988199 |