| thyroid hormone levels in children with prader-willi syndrome before and during growth hormone treatment. | prader-willi syndrome (pws) is a neurogenetic disorder characterized by muscular hypotonia, psychomotor delay, obesity and short stature. several endocrine abnormalities have been described, including gh deficiency and hypogonadotrophic hypogonadism. published data on thyroid hormone levels in pws children are very limited. | 2007 | 17716335 |
| the prognostic value of hemoglobin concentration in postoperative radiotherapy of 835 patients with laryngeal cancer. | to investigate the prognostic value of hemoglobin (hb) concentration in patients with laryngeal cancer treated with postoperative radiotherapy (prt). | 2007 | 17716825 |
| continuous positive airway pressure breathing increases cranial spread of sensory blockade after cervicothoracic epidural injection of lidocaine. | continuous positive airway pressure (cpap) increases the caudad spread of sensory blockade after low-thoracic epidural injection of lidocaine. we hypothesized that cpap would increase cephalad spread of blockade after cervicothoracic epidural injection. | 2007 | 17717252 |
| hyperthyroidism induces glucose intolerance by lowering both insulin secretion and peripheral insulin sensitivity. | the objectives of this study were to examine the effects of hyperthyroidism on glucose tolerance, insulin secretion, and insulin sensitivity. | 2006 | 17718254 |
| the incidence and risk factors of hypotension and bradycardia associated with spinal anesthesia. | hypotension and bradycardia after conduction of spinal anesthesia are common and may lead to intraoperative cardiac arrest or death. the present study was carried out to investigate the incidence and risk factors of hypotension and/or bradycardia in the patients receiving spinal anesthesia. | 2006 | 17718270 |
| prognostic factors in resected satellite-nodule t4 non-small cell lung cancer. | the 1997 non-small cell lung cancer staging revisions assigned a t4 descriptor to satellite nodules in the primary tumor lobe. we reviewed our experience of satellite-nodule t4 non-small cell lung cancer following these revisions and evaluated prognostic factors for this group. | 2007 | 17720402 |
| [breast cancer in elderly women in tunisia. retrospective study of 106 patients older than 65 years]. | objective: to report the epidemiological profile, anatomo - clinic, prognostic and therapeutic of breast cancers in aged woman from the region of the center of tunisia. our retrospective study concern 106 patients with mammary cancers treated between january 1990 and december 1997 at the farhat hached hospital in sousse (tunisia). the mean age was 71 years (extremes 65-91), 66% of the patients had an age more than 75 years, the mean age at the menopause was of 50 years. the size middle clinic wa ... | 2003 | 17722781 |
| cd4 count, viral load and parasite density of hiv positive individuals undergoing malaria treatment with dihydroartemisinin in benin city, edo state, nigeria. | a prospective study on 72 hiv infected and 33 hiv negative individuals undergoing malaria treatment with dihydroartemisinin (cotecxin) was undertaken to compare cd4 cells count, viral load and parasite density at two time-points, a baseline visit and a 9-day post-treatment visit. | 2007 | 17722864 |
| sarcomatoid lung cancer (spindle/giant cells): an aggressive disease? | we investigated the clinical, surgical, and pathologic features of sarcomatoid lung carcinomas with spindle/giant cells, giving special attention to the prognostic behavior of these rare tumors. | 2007 | 17723808 |
| phage-antibiotic synergy (pas): beta-lactam and quinolone antibiotics stimulate virulent phage growth. | although the multiplication of bacteriophages (phages) has a substantial impact on the biosphere, comparatively little is known about how the external environment affects phage production. here we report that sub-lethal concentrations of certain antibiotics can substantially stimulate the host bacterial cell's production of some virulent phage. for example, a low dosage of cefotaxime, a cephalosporin, increased an uropathogenic escherichia coli strain's production of the phage phimfp by more tha ... | 2007 | 17726529 |
| vertebral body shape variation in the thoracic and lumbar spine: characterization of its asymmetry and wedging. | this study was designed to characterize the vertebral body (vb) shape, focusing on vertebral wedging, along the thoracic and lumbar spine, and to look for shape variations with relation to gender, age, and ethnicity. all thoracic and lumbar (t1-l5) dissected vertebrae of 240 individuals were measured and analyzed by age, gender, and ethnicity. a 3d digitizer was used to measure all vb lengths, heights, and widths, and their ratios were calculated. this study showed that the vb size was independe ... | 2008 | 17729333 |
| iodine-131 radio-guided surgery in differentiated thyroid cancer: outcome on 31 patients and review of the literature. | in the present study we investigated the role of radio-guided surgery with iodine-131 (i-131) in a group of 31 patients with differentiated thyroid cancer (dtc) and loco-regional recurrent disease. the principal inclusion criterion for i-131 radio-guided surgery in our protocol was the presence of an i-131 positive loco-regional disease relapse after previous total thyroidectomy and at least 2 ineffective conventional i-131 treatments. the protocol we used consisted of the following steps. day 0 ... | 2007 | 17761397 |
| 2'-deoxyimmunosine: a thiazolo[4,5-d]pyrimidine nucleoside adopting the syn conformation. | the title compound [systematic name: 5-amino-3-(2-deoxy-beta-d-erythro-pentofuranosyl)thiazolo[4,5-d]pyrimidine-2,7-(3h,6h)-dione], c(10)h(12)n(4)o(5)s, exhibits a syn glycosylic bond conformation, with a torsion angle chi of 61.0 (3) degrees. the furanose moiety adopts the n-type sugar pucker ((3)t4), with p = 33.0 (5) degrees and tau(m) = 15.1 (1) degrees. the conformation at the exocyclic c4'-c5' bond is +ap (trans), with the torsion angle gamma = 176.71 (14) degrees. the extended structure i ... | 2007 | 17762130 |
| the iaslc lung cancer staging project: proposals for revision of the m descriptors in the forthcoming (seventh) edition of the tnm classification of lung cancer. | to analyze all nonlymphatic metastatic components (t4 and m1) of the current tnm system of lung cancer, with the objective of providing suggestions for the next edition of the tnm classification for lung cancer. | 2007 | 17762334 |
| the iaslc lung cancer staging project: proposals for the revision of the tnm stage groupings in the forthcoming (seventh) edition of the tnm classification of malignant tumours. | the seventh edition of the tnm classification of malignant tumors is due to be published early in 2009. in preparation for this, the international association for the study of lung cancer established its lung cancer staging project in 1998. the recommendations of this committee for changes to the t, n, and m descriptors have been published. this report contains the proposals for the new stage groupings. | 2007 | 17762336 |
| fdg-pet/ct tumor segmentation-derived indices of metabolic activity to assess response to neoadjuvant therapy and progression-free survival in esophageal cancer: correlation with histopathology results. | to evaluate the diagnostic and prognostic abilities of pet tumor segmentation-derived indices of metabolic activity for the assessment of response to neoadjuvant chemoradiotherapy and progression-free survival in patients with esophageal cancer. | 2007 | 17762438 |
| dose escalation for patients with locally advanced nasopharyngeal carcinoma treated with radiotherapy alone. | the local control of patients with locally advanced nasopharyngeal carcinoma is still unsatisfactory. this prospective study was designed to evaluate the treatment outcomes and treatment-related complications of patients with locally advanced nasopharyngeal carcinoma treated with escalated radiation doses. | 2007 | 17762441 |
| oropharyngectomy without mandibulotomy in advanced stage (t3-t4) oropharyngeal cancer. | the postoperative course was excellent for this type of surgery, and the functional recovery was comparable to that obtained with much more laborious techniques. | 2007 | 17763001 |
| comparison of approaches for oral cavity cancer resection: lip-split versus visor flap. | to compare lip-split and visor flap approaches to the oral cavity in terms of morbidity, margins, and locoregional recurrence. | 2007 | 17765770 |
| transoral laser microsurgery for untreated glottic carcinoma. | to report the oncology and functional outcomes of transoral laser microsurgery (tlm) for untreated glottic carcinoma. | 2007 | 17765780 |
| multiple thyroid ectopics in a single patient: a rare presentation. | a rare case of multiple thyroid ectopics has been presented. a 16 years old girl presented with swelling on the right side of neck and sense of lump in the throat. oral examination confirmed presence of lingual thyroid. examination of neck confirmed a 4 cm rounded soft mass on upper right side of patient's neck. thyroid scan with i131 showed uptake of radio-iodine at the tongue base and also on right side of neck. biopsy of mass from tongue dorsum and fna from neck mass confirmed presence of thy ... | 2007 | 17785132 |
| recurrent herpes zoster in early childhood. | herpes zoster is produced by reactivation of latent varicella zoster virus from the dorsal root ganglion of sensory nerves. it is common in older individuals and rarely described in the pediatric age group. we report a case of recurrent herpes zoster in a 3-year-old hiv positive child involving t4 dermatome on the first occasion and subsequently involving t10 dermatome. the child responded well to oral acyclovir. | 2007 | 17785904 |
| cytokeratin 17 mrna expression has potential for diagnostic marker of oral squamous cell carcinoma. | determination of marker for identification of oral squamous cell carcinoma (oscc) is important for early diagnosis and individual therapy. cytokeratins (cks) like ck 19 and ck 20 are known to be useful diagnostic and prognostic markers for solid tumors. the aim of this study was to evaluate the relevance of further cks for diagnosis of oscc. | 2008 | 17786476 |
| surgical volume influences survival in patients undergoing resections for stage ii colon cancers. | there is current interest in the correlation between surgical volume and outcomes. survival in patients with rectal cancer appears to improve when carried out by surgeons who do high volumes of procedures. a similar correlation for patients with colon cancer has never been clearly established. the aim of this study was to determine whether surgical volume was an independent predictor for survival in patients undergoing surgery for stage ii colon cancer. | 2007 | 17803560 |
| effects of serum tsh and ft4 levels and the tshr-asp727glu polymorphism on bone: the rotterdam study. | tsh and thyroid hormone may have independent effects on bone. in this study we investigated the association of tsh and free t4 (ft4) with different bone parameters in human subjects. tsh and ft4 are known to be associated with body mass index (bmi) and a higher bmi gives a higher bone mineral density (bmd). thus, we aimed to determine whether the effects of tsh and ft4 on bone are mediated by bmi. as tsh exerts its biological effect through the tsh receptor (tshr), the tshr gene might be a candi ... | 2008 | 17803697 |
| feasibility of using interpolated contours of targets and organs at risk in intensity-modulated radiation therapy treatment planning for advanced-stage nasopharyngeal carcinoma. | to assess the dosimetric effect of using interpolated contours in planning intensity-modulated radiation therapy (imrt) for advanced t-stage nasopharyngeal carcinoma. the present study focused on t3-t4 tumours where the proximity of targets to neurological organs poses a stringent test on the feasibility of such an approach. contours of targets and organs were delineated on ct images of 2.5-mm interval and a reference imrt plan was generated. an investigative (inv) imrt plan was then generated w ... | 2007 | 17803802 |
| [the value of cervical lymph node ultrasound examination in patients suffering from laryngeal cancer]. | 51 patients with laryngeal cancer were surgically treated on the ent departament of the st lukas district hospital in tarnow between the years 1997-2000. the local advancement was stated as t3 and t4 according to the tnm system. the high grade of tumour differentiation (g1) was established in 13 patients (25.5%), mediam (g2) in 22 (43.1%), and low grade (g3) in 16 patients (31.4%). according to usg examination lymph nodes were estimated as no in 20 patients (39.2%), as n1 in 21 (41.2%), and as n ... | 2006 | 17806194 |
| systemic uptake of diethyl phthalate, dibutyl phthalate, and butyl paraben following whole-body topical application and reproductive and thyroid hormone levels in humans. | in vitro and animal studies have reported endocrine-disrupting activity of chemicals used commonly as additives in cosmetics and skin care products. we investigated whether diethyl phthalate (dep), dibutyl phthalate (dbp), and butyl paraben (bp) were systemically absorbed and influenced endogenous reproductive and thyroid hormone levels in humans after topical application. in a two-week single-blinded study, 26 healthy young male volunteers were assigned to daily whole-body topical application o ... | 2007 | 17822133 |
| the phage t4 protein uvsw drives holliday junction branch migration. | the phage t4 uvsw protein has been shown to play a crucial role in the switch from origin-dependent to recombination-dependent replication in t4 infections through the unwinding of origin r-loop initiation intermediates. uvsw also functions with uvsx and uvsy to repair damaged dna through homologous recombination, and, based on genetic evidence, has been proposed to act as a holliday junction branch migration enzyme. here we report the purification and characterization of uvsw. using oligonucleo ... | 2007 | 17823128 |
| external beam radiotherapy and high dose rate brachytherapy for medically unfit and elderly patients. | in the treatment of rectal cancer, total mesorectal excision surgery is now the standard of care. in most patients, surgery will be preceeded by radiotherapy, either in a short course (25 gy/five fractions) or in a conventional schedule (45-50 gy/25 fractions) with chemotherapy. for patients unfit for surgery or unwilling to undergo a procedure resulting in a permanent colostomy, radiotherapy without surgery is the alternative. from published studies it is clear that for relatively small tumours ... | 2007 | 17826039 |
| [experiences in treatment and follow up of 50 patients with penile cancer]. | malignant tumour of the penis is a rare disease. although most of the cases are squamous cell carcinoma histologically, operation is managed by the urologist because of its location. | 2007 | 17827084 |
| epidural infusion of levobupivacaine and sufentanil following thoracotomy. | a prospective, randomised, double-blind study was conducted to compare the efficacy of two doses of levobupivacaine combined with sufentanil for continuous epidural infusion following thoractomy. a total of 72 patients undergoing lobectomy or pneumonectomy were enrolled. an epidural catheter was inserted between the levels of t4 and t6 before induction of anaesthesia and a loading dose of levobupivacaine and sufentanil was administered. at the end of surgery an epidural infusion was commenced at ... | 2007 | 17845650 |
| [locally advanced prostate cancer: definition, prognosis and treatment]. | according to d'amico's criteria, high-risk localized prostate cancer are defined either by an extracapsular extension (t3 or t4), either by a high gleason score (> 7) or a psa rate higher than 20 ng/ml. pelvic lymph node involvement also corresponds to locally advanced prostate cancer. statistical models called nomograms have been developed to predict the probability of prostate cancer recurrence and are also used to define locally advanced patients. prostate mri may help to detect an extracapsu ... | 2007 | 17845994 |
| pegfilgrastim +/- ciprofloxacin for primary prophylaxis with tac (docetaxel/doxorubicin/cyclophosphamide) chemotherapy for breast cancer. results from the gepartrio study. | tac (docetaxel/doxorubicin/cyclophosphamide) is associated with high incidences of grade 4 neutropenia and febrile neutropenia (fn). this analysis compared the efficacies of four regimens for primary prophylaxis of fn and related toxic effects in breast cancer patients receiving neoadjuvant tac. | 2008 | 17846019 |
| mucinous rectal adenocarcinoma can be associated to tumor downstaging after preoperative chemoradiotherapy. | the aim of this study was to evaluate downstaging as primary end point, and progression-free survival and overall survival as secondary end points, in rectal adenocarcinoma patients treated with preoperative chemoradiation. | 2007 | 17846841 |
| [radiotherapy after radical prostatectomy: description, outcome and prognostic factors in and emerging practice]. | recently it has been reported in the eortc (european organisation for research and treatment of cancer) trial 22911 and the swog (southwest oncology group) 8794, the evidence that radiotherapy (rt) is an effective treatment after the prostatectomy in patients with high risk of biochemical failure. we analyze predictor factors of biochemical relapse and the potential benefits induced by rescue treatment are the main purposes of our study. | 2007 | 17847737 |
| effect of semen collection frequency on seasonal variation in sexual behaviour, testosterone, testicular size and semen characteristics of tropical hair rams (ovis aries). | the purpose of this study was to examine the effect of day length on seminal characteristics, testicular size, sexual behaviour and testosterone (t4) concentration in pelibuey rams subjected to different semen collection frequencies. eighteen intact males were assigned randomly to one of two semen collection frequencies: in the high rate (hr) treatment, two ejaculations per week were obtained from each ram; one ejaculation every two weeks was collected under the low rate (lr) treatment. all anim ... | 2007 | 17847822 |
| intensity-modulated radiation therapy in the treatment of head and neck cancer involving the base of the skull. | tumors invading the skull base pose a difficult problem for the treating radiation oncologist. when confronting these highly complex tumors where the gross tumor abuts the optic apparatus or brain stem, the physician often has to make a difficult choice regarding coverage of the tumor, i.e., underdosing portions of the tumor to protect the critical normal tissues versus accepting the risk of late complication while ensuring full coverage of the tumor. this situation is often encountered in advan ... | 2007 | 17848292 |
| effects of cardiopulmonary bypass on thyroid function. | alterations in serum concentration of thyroid hormones occur even in euthyroid patients undergoing cardiopulmonary bypass. the purpose of our prospective study was to define the effects of cardiopulmonary bypass on thyroid hormones. twenty euthyroid patients for mitral valve replacement were included in this study. heparinised arterial sample for thyroid function tests were obtained before cardiopulmonary bypass (cpb), 30 and 60 minutes after initiation of cpb, immediate post-cpb and 24 hours af ... | 2000 | 17848764 |
| distinct molecular phenotype of inflammatory breast cancer compared to non-inflammatory breast cancer using affymetrix-based genome-wide gene-expression analysis. | the present study aims at a platform-independent confirmation of previously obtained cdna microarray results on inflammatory breast cancer (ibc) using affymetrix chips. gene-expression data of 19 ibc and 40 non-ibc specimens were subjected to clustering and principal component analysis. the performance of a previously identified ibc signature was tested using clustering and gene set enrichment analysis. the presence of different cell-of-origin subtypes in ibc was investigated and confirmed using ... | 2007 | 17848951 |
| prevalence of vitamin d insufficiency in obese children and adolescents. | recent studies have shown a broad prevalence of vitamin d deficiency in adults. serum 25-hydroxyvitamin d (25-ohd) levels were reported to be inversely related to body mass index (bmi) and body fat content and correlated directly with hypertension, degree of insulin resistance and progression to diabetes mellitus. we sought to determine the prevalence of vitamin d insufficiency and markers of metabolic syndrome in an obese pediatric population. | 2007 | 17849744 |
| does a highly sensitive thyroglobulin (tg) assay change the clinical management of low-risk patients with thyroid cancer with tg on t4 < 1 ng/ml determined by traditional assays? | to evaluate a highly sensitive thyroglobulin (tg) assay [functional sensitivity (fs): 0.1 ng/ml] (tg-icma) in low-risk patients with known tg on t4 < or = 1 ng/ml measured by a traditional assay (fs: 1 ng/ml) (tg-irma). | 2008 | 17850379 |
| carbamazepine and risk of hypothyroidism: a prospective study. | objectives - while carbamazepine (cbz) decreases thyroid hormone concentrations it rarely causes hypothyroidism. we assessed prospectively the early effect of cbz on thyroid status in thyroxine-supplemented hypothyroid patients, when compared with patients without a thyroid disorder. methods - in 29 patients, thyrotropin (tsh), total thyroxine (tt4) and free thyroxine (ft4) serum levels were assayed before starting cbz, and then weekly for 7 weeks. nineteen patients with no thyroid disorder (gro ... | 2007 | 17850408 |
| periodontopathic microorganisms in peripheric blood after scaling and root planing. | the objective of this study was to evaluate the frequency of periodontopathic and other subgingival anaerobic and facultative bacteria in the bloodstream following scaling and root planing (srp). | 2007 | 17850606 |
| cryo-em study of the pseudomonas bacteriophage phikz. | the phikz virus is one of the largest known bacteriophages. it infects pseudomonas aeruginosa, which is frequently pathogenic in humans, and, therefore, has potential for phage therapy. the phikz virion consists of an approximately 1450 a diameter icosahedral head and an approximately 2000 a long contractile tail. the structure of the phikz tail has been determined using cryo-electron microscopy. the phikz tail is much longer than that of bacteriophage t4. however, the helical parameters of thei ... | 2007 | 17850749 |
| primary tumor volume calculation as a predictive factor of prognosis in nasopharyngeal carcinoma. | primary tumor volume (ptv) has a close relationship with survival rates of patients with nasopharyngeal carcinoma (npc) who were treated with concurrent chemoradiotherapy (ccrt) or radiotherapy. besides the current ajcc staging system, measurement of ptv may be needed to predict prognosis of npc and adjust treatment strategy. | 2008 | 17851945 |
| [c-fos protein expression in the parietal cortex and olfactory tubercle in the hypoxic rat brain]. | we have attempted to identify which parts of the brain react to ischemic attack using the four-vessel occlusion model in rats. | 2007 | 17853723 |
| ["is my brother's life in the institution still safe? or one day he gets "pneumonia" (...) and we get the urn???)" [1]--the relatives of institution patients during national-socialism patient killing action "t4"]. | | 2007 | 17853785 |
| thymidylate synthase and thymidine phosphorylase gene expression as predictive parameters for the efficacy of 5-fluorouracil-based adjuvant chemotherapy for gastric cancer. | to investigate the prognostic role of thymidylate synthase (ts) and thymidine phosphorylase (tp) mrna levels in t3 or t4 gastric cancer treated with 5-fluorouracil-based adjuvant chemotherapy. | 2007 | 17854149 |
| phase i trial of neoadjuvant preoperative chemotherapy with s-1 and irinotecan plus radiation in patients with locally advanced rectal cancer. | to determine the maximum tolerated dose (mtd) and recommended dose (rd) of irinotecan combined with preoperative chemoradiotherapy with s-1 in patients with locally advanced rectal cancer. | 2007 | 17855009 |
| supracricoid laryngectomy with cricohyoidoepiglotto-pexy or cricohyoido-pexy: experience on 32 patients. | supracricoid laryngectomy (scl) with cricohyoidoepiglotto-pexy (chep) or cricohyoido-pexy (chp) is an organ preservation surgery indicated for early and selected advanced laryngeal cancers. to verify the clinical usefulness of supracricoid laryngectomy versus total laryngectomy, a retrospective review was conducted. | 2008 | 17869042 |
| type vi secretion system translocates a phage tail spike-like protein into target cells where it cross-links actin. | genes encoding type vi secretion systems (t6ss) are widely distributed in pathogenic gram-negative bacterial species. in vibrio cholerae, t6ss have been found to secrete three related proteins extracellularly, vgrg-1, vgrg-2, and vgrg-3. vgrg-1 can covalently cross-link actin in vitro, and this activity was used to demonstrate that v. cholerae can translocate vgrg-1 into macrophages by a t6ss-dependent mechanism. protein structure search algorithms predict that vgrg-related proteins likely assem ... | 2007 | 17873062 |
| special treatment issues in lung cancer: accp evidence-based clinical practice guidelines (2nd edition). | this chapter of the guidelines addresses patients who have particular forms of non-small cell lung cancer that require special considerations. this includes patients with pancoast tumors, t4n0,1m0 tumors, satellite nodules in the same lobe, synchronous and metachronous multiple primary lung cancers (mplcs), solitary brain and adrenal metastases, and chest wall involvement. | 2007 | 17873175 |
| hypothyroidism and hyperthyroidism modulates ras-mapk intracellular pathway in rat thyroids. | thyrotrophin induces proliferation and function in thyroid cells acting through a seven transmembrane g protein-coupled receptor. the proliferative pathways induced by thyrotropin (tsh) in thyrocytes in vivo are not completely understood yet. the aim of this work is to evaluate if ras can be induced by tsh in rat thyroids, and whether extracellular regulated kinase (erk) may be involved in the subsequent intracellular signalling cascade. we induced hypothyroidism in wistar rats by methimazole (m ... | 2007 | 17873330 |
| effects of selenium and tellurium on the activity of selenoenzymes glutathione peroxidase and type i iodothyronine deiodinase, trace element thyroid level, and thyroid hormone status in rats. | tellurium (te) and selenium (se) belong chemically to the via group of elements. se represents an essential element closely related to thyroid function. te has growing application in industrial processes. little is known about the te biological activity, particularly with respect to potential chemical interactions with se-containing components in the organism. in this study, female wistar rats (body weight: 115-120 g) received sodium selenite pentahydrate (10 mg/l) or sodium tellurite (9.4 mg/l) ... | 2007 | 17873396 |
| oncological results of surgical treatment of malignant tumors of the nasal vestibule. | we evaluated functional results of surgical treatment for squamous cell carcinoma of the nasal vestibule. | 2007 | 17873502 |
| crystal structure of t4 endonuclease vii resolving a holliday junction. | holliday proposed a four-way dna junction as an intermediate in homologous recombination, and such holliday junctions have since been identified as a central component in dna recombination and repair. phage t4 endonuclease vii (endo vii) was the first enzyme shown to resolve holliday junctions into duplex dnas by introducing symmetrical nicks in equivalent strands. several holliday junction resolvases have since been characterized, but an atomic structure of a resolvase complex with a holliday j ... | 2007 | 17873859 |
| in vitro glucuronidation of thyroxine and triiodothyronine by liver microsomes and recombinant human udp-glucuronosyltransferases. | glucuronidation, which may take place on the phenolic hydroxyl and carboxyl groups, is a major pathway of metabolism for thyroxine (t4) and triiodothyronine (t3). in this study, a liquid chromatography/mass spectrometry (lc/ms) method was developed to separate phenolic and acyl glucuronides of t4 and t3. the method was used to collect the phenolic glucuronide of t4 for definitive characterization by nmr and to determine effects of incubation ph, species differences, and human udp-glucuronosyltra ... | 2007 | 17875670 |
| full correlation analysis of conformational protein dynamics. | correlated motions in biomolecules are often essential for their function, for example, allosteric signal transduction or mechanical/thermodynamic energy transport. principal component analysis (pca) is a widely used method to extract functionally relevant collective motions from a molecular dynamics (md) trajectory. being based on the covariance matrix, however, pca detects only linear correlations. here we present a new method, full correlation analysis (fca), which is based on mutual informat ... | 2008 | 17876828 |
| dosimetric comparison between coplanar and non coplanar field radiotherapy for ethmoid sinus cancer. | to compare non coplanar field (ncf) with coplanar field (cf) -intensity-modulated radiotherapy (imrt) planning for ethmoid cancer. | 2007 | 17877793 |
| crystallographic and nmr analyses of uvsw and uvsw.1 from bacteriophage t4. | the uvswxy system is implicated in the replication and repair of the bacteriophage t4 genome. whereas the roles of the recombinase (uvsx) and the recombination mediator protein (uvsy) are known, the precise role of uvsw is unclear. sequence analysis identifies uvsw as a member of the monomeric sf2 helicase superfamily that translocates nucleic acid substrates via the action of two reca-like motor domains. functional homologies to escherichia coli recg and biochemical analyses have shown that uvs ... | 2007 | 17878153 |
| the effect of changes in the bulk dielectric constant on the dna torsional properties. | the effect of changes in the bulk dielectric constant on the dna torsional properties was evaluated from plasmid circularization reactions. in these reactions, puc18 previously linearized by ecori digestion was recircularized with t4 dna ligase. the bulk dielectric constant of the reaction medium was decreased by the addition of different concentrations of neutral solutes: ethylene glycol, glycerol, sorbitol, and sucrose, or increased by the addition of glycine. the topoisomers generated by the ... | 2007 | 17879331 |
| phase i-ii trial of cetuximab, capecitabine, oxaliplatin, and radiotherapy as preoperative treatment in rectal cancer. | to evaluate the safety and activity of preoperative radiotherapy (rt) with concurrent cetuximab, capecitabine, and oxaliplatin in rectal cancer patients. | 2008 | 17881150 |
| rectal cancer: incidence of pulmonary metastases on thoracic ct and correlation with t staging. | the aim of the study was to evaluate the incidence of pulmonary metastases detected on thoracic computed tomography in patients with rectal cancer and assess the association between the incidence of pulmonary metastases and the stage of the rectal tumor. | 2007 | 17882033 |
| [cervical lymph node metastasis of pyriform sinus carcinoma]. | to investigate the characteristic of cervical lymph node metastasis of pyriform sinus carcinoma. | 2007 | 17882971 |
| assessment of the factors involving in the development of hypothyroidism in hiv-infected patients: a case-control study. | increased prevalence of thyroid dysfunction has been reported in hiv-infected patients, and recent studies have shown hypothyroidism as the most common thyroid function abnormality in this population, especially after treatment with antiretroviral drugs (haart). the aim of this study is to assess risk factors of hypothyroidism in hiv-infected patients in iran. | 2007 | 17885731 |
| integration of signaling pathways regulating chondrocyte differentiation during endochondral bone formation. | during endochondral bone formation, chondrocytes undergo a process of terminal differentiation or maturation, during which the rate of proliferation decreases, cells become hypertrophic, and the extracellular matrix is altered by production of a unique protein, collagen x, as well as proteins that promote mineralization. the matrix surrounding the hypertrophic chondrocytes eventually becomes mineralized, and the mineralized matrix serves as a template for bone deposition. this process is respons ... | 2007 | 17886256 |
| the influence of epidural volume extension on spinal block with hyperbaric or plain bupivacaine for caesarean delivery. | epidural volume extension via a combined spinal-epidural is the enhancement of a small-dose intrathecal block by an epidural injection of physiological saline solution. we evaluated the effect of epidural volume extension on the combined spinal-epidural technique of providing spinal anaesthesia for caesarean section with hyperbaric or plain 0.5% bupivacaine. | 2008 | 17888192 |
| thyroid hormones down-regulate thyrotropin beta subunit and thyroglobulin during metamorphosis in the flatfish senegalese sole (solea senegalensis kaup). | thyroid hormones (th) play a critical role in flatfish metamorphosis. their levels are regulated by the pituitary-thyroid axis. the expression profile of thyroid stimulating hormone (tsh) beta subunit and thyroglobulin (tg) was investigated using a real-time pcr approach. both genes exhibited different expression patterns during larval development in senegalese sole. tsh beta mrnas reduced progressively at the commencement of metamorphosis. on the contrary, tg transcripts increased sharply at th ... | 2008 | 17888916 |
| direct equilibrium dialysis compared with two non-dialysis free t4 methods in premature infants. | to compare the incidence of low free t4 values reported by a direct equilibrium dialysis method to their incidence reported by 2 non-dialysis methods. | 2007 | 17889078 |
| detrended fluctuation analysis of resting eeg in depressed outpatients and healthy controls. | recent findings have demonstrated that the eeg possesses long-range temporal (auto-) correlations (lrtc) in the dynamics of broad band oscillations. the analysis of lrtc provides a quantitative index of statistical dependencies in oscillations on different time scales. we analyzed lrtc in resting eeg signals in depressed outpatients and healthy controls. | 2007 | 17890151 |
| the nuclear pp1 interacting protein zap3 (zap) is a putative nucleoside kinase that complexes with sam68, cia, nf110/45, and hnrnp-g. | the targeting of protein kinases and phosphatases is fundamental to their roles as cellular regulators. the type one serine/threonine protein phosphatase (pp1) is enriched in the nucleus, yet few nuclear pp1 targeting subunits have been described and characterized. here we show that the human protein, zap3 (also known as zap), is localized to the nucleus, that it is expressed in all mammalian tissues examined, and docks to pp1 through an rvrw motif located in its highly conserved carboxy-terminu ... | 2007 | 17890166 |
| [recombinant human tsh use in differentiated thyroid cancer]. | traditionally, the immediate treatment of patients with differentiated thyroid carcinoma (dtc) after total thyroidectomy (tt) is thyroid remnant ablation (tra) with 131i, during hypothyroidism. late follow-up of dct includes suppressive doses of t4, serial measurements of thyroglobulin (tg), whole body scan (wbs) with 131i and cervical ultrasound (us). in the last years, tra with the aid of recombinant human tsh (rhtsh) has shown not only to avoid symptoms of hypothyroidism and a lower quality o ... | 2007 | 17891244 |
| [clinical repercussion of the 6th edition tnm staging system classification on differentiated thyroid carcinoma]. | the tnm classification of uicc is used for predicting the outcome of thyroid cancer. the 6th edition changed the description of primary tumor (t), regional lymph node (n) and the staging group. the aim of this study was to compare the ability of the 5th and the 6th editions to predict outcome. the two classifications were applied in a retrospective analysis of 90 patients from hucff. sixty-nine patients had papillary carcinoma, 14 follicular, 4 hürthle cell, and 3 mixed. patients were followed f ... | 2007 | 17891247 |
| [will the thyroglobulin assay with lower functional sensitivity whilst the patients are on l-t4 treatment replace the tsh-stimulated thyroglobulin assay in the follow-up of patients with differentiated thyroid cancer?]. | the author reviews the literature on the new assays for serum thyroglobulin (stg) presenting lower functional sensitivity and demonstrates that its use, whilst the patients are taking l-t4, presents better results than stg following tsh stimulation in the follow-up of patients with differentiated thyroid carcinoma. therefore, he suggests a revision on the guidelines for the follow-up of these patients (developed when the available assays present a sensitivity of 1 ng/ml), proposing the use of st ... | 2007 | 17891252 |
| a role of rnla in the rnase ls activity from escherichia coli. | escherichia coli ribonuclease ls is a potential antagonist of bacteriophage t4. when the t4 dmd gene is defective, rnase ls cleaves t4 mrnas and antagonizes t4 reproduction. our previous work demonstrated that e. coli rnla is essential for rnase ls activity. here we show that his-tagged rnla cleaves t4 soc rna at one of the sites also cleaved by rnase ls in a cell extract. the cleavage activities of his-tagged rnla and the rnase ls activity in a cell extract were inhibited by dmd encoded by t4 p ... | 2007 | 17895580 |
| reference range of thyroid hormones in normal indian school-age children. | there is an ongoing debate on narrowing the tsh reference range in adults. in view of the scarce data on normal values of thyroid function tests in children from india, we planned to establish a reference range for thyroid hormones in school-age children. | 2008 | 17897329 |
| [preoperative treatments of rectal cancers]. | surgery alone is no longer appropriate to the treatment of t3-t4 resecable rectal cancer. preoperative chemoradiotherapy has recently been approved as the new standard treatment. this approach improves local control with local failure rate raranging now around 6-8%. however, it does not impact on overall survival. it becomes urgent to develop new concepts and a basic research in the understanding of the biological mechanisms that may explain the resistance of the micrometastatic process. | 2007 | 17897858 |
| gestation-specific thyroxine and thyroid stimulating hormone levels in the united states and worldwide. | euthyroid women experience dramatic changes in the demand for thyroid hormone production as early as the first trimester of pregnancy. these changes are important for fetal neurodevelopment and organ development as well as maternal health and succesful full term pregnancy. therefore, gestation-specific reference intervals assist in appropriate clinical management of thyroid disease in pregnancy to ensure maternal and fetal health. | 2007 | 17898643 |
| clinical benefit of palliative radiation therapy in advanced gastric cancer. | local progression of advanced gastric cancer often manifests as bleeding, dysphagia/obstruction, or pain. we evaluated the magnitude and durability of palliation with radiotherapy (rt). | 2008 | 17899453 |
| [mosaic expression pattern of the nptii gene in transgenic tobacco plants nu 21]. | mosaic expression pattern of the nptii gene in transgenic tobacco nu 21 leaf somatic cells was demonstrated. inheritance of this phenotype (in t1-t4 and f1 backcrosses) was revealed. three plant groups were distinguished, with low frequency of variegation manifestation (0-21.8%), with the high frequency of mosaic progeny (63.1 to 100%), and the intermediate type, where the frequency of the appearance of mosaic plants varied in a wide range, from 0 to 100%. the data obtained suggested the existen ... | 2007 | 17899813 |
| rz/rz1 lysis gene equivalents in phages of gram-negative hosts. | under usual laboratory conditions, lysis by bacteriophage lambda requires only the holin and endolysin genes, but not the rz and rz1 genes, of the lysis cassette. defects in rz or rz1 block lysis only in the presence of high concentrations of divalent cations. the lambda rz and rz1 lysis genes are remarkable in that rz1, encoding an outer membrane lipoprotein, is completely embedded in the +1 register within rz, which itself encodes an integral inner membrane protein. while rz and rz1 equivalent ... | 2007 | 17900620 |
| electrophysiological analysis of a sensorimotor integration task. | the present experiment aimed at investigating electrophysiologic changes observed as beta band asymmetry, by quantitative electroencephalography (qeeg), when individuals performed a reaching motor task (catching a ball in free fall). the sample was composed of 23 healthy individuals, of both sexes, with ages varying between 25 and 40 years old. all the subjects were right handed. a two-way anova was applied for the statistical analysis, to verify the interaction between task moment (i.e., 2s bef ... | 2007 | 17900806 |
| stress fracture of the tibia following a vascularised free fibular flap. | a 49-year-old female presented with a t4 n2 mo moderately differentiated squamous cell carcinoma of the right cheek mucosa and involving the mandible. patient treatment included resection of the tumour with partial mandibulectomy, maxillectomy and a free osteocutaneous fibular flap to reconstruct the bony mandibular and soft tissue intraoral defects. six weeks postoperatively the patient developed a stress fracture of the right tibia, a complication which has not been reported in the literature ... | 2008 | 17901006 |
| prevention of atrial fibrillation after coronary artery bypass graft surgery using a potassium-magnesium-aspartate solution (inzolen). | atrial fibrillation (afib) following cardiac surgery is a frequent complication. the purpose of this study was to evaluate the efficacy of a potassium-magnesium-aspartate solution (inzolen) for the prevention of afib. | 2007 | 17902062 |
| gastric carcinoma: typing, staging, lymph node and resection margin status on gastrectomy specimens. | objective: to determine the extent and stage of gastric carcinoma on gastrectomy specimens in terms of type, grade, location, depth of invasion, resection margins and lymph node status. study design: descriptive study. place and duration of study: section of histopathology, department of pathology, aga khan university, karachi during 2005 and 2006. materials and methods: a 100 consecutive gastrectomy specimens received during the study period, in which resection was done for gastric carcinoma we ... | 2007 | 17903401 |
| phase ii study of preoperative helical tomotherapy for rectal cancer. | to explore the efficacy and toxicity profile of helical tomotherapy in the preoperative treatment of patients with rectal cancer. | 2008 | 17904302 |
| extraosseous epidural multiple myeloma presenting with thoracic spine compression. | multiple myeloma is a hematopoetic disorder and multicentric disease, with the most common localisation being the spine. a 47-year-old male presented with progressive paraplegia, superficial and deep sensory disturbance below the level of t4. spinal magnetic resonance image showed an epidural mass compressing the spinal cord at the level of t4-t6 with intact bone structure. the patient underwent surgical t4-t6 posterior spinal decompression. microscopic examination and immunohistochemical studie ... | 2008 | 17905632 |
| video-assisted thoracic sympathectomy in the treatment of primary hyperhidrosis: a retrospective study of 521 cases comparing different levels of ablation. | to compare different levels of ablation in terms of the degree of patient satisfaction and extent of postoperative reflex sweating in sympathectomized patients. | 2007 | 17906784 |
| trigenomic chromosomes by recombination of thinopyrum intermedium and th. ponticum translocations in wheat. | rusts and barley yellow dwarf virus (bydv) are among the main diseases affecting wheat production world wide for which wild relatives have been the source of a number of translocations carrying resistance genes. nevertheless, along with desirable traits, alien translocations often carry deleterious genes. we have generated recombinants in a bread wheat background between two alien translocations: tc5, ex-thinopyrum (th) intermedium, carrying bydv resistance gene bdv2; and t4m, ex-th. ponticum, c ... | 2007 | 17906848 |
| influence of preoperative mri on the surgical management of patients with operable breast cancer. | evaluation of the impact of preoperative magnetic resonance imaging (mri) of the breast on the clinical management of patients with operable breast cancer (bc). | 2008 | 17906928 |
| [the male breast carcinoma: a center experience]. | male breast carcinoma represents a rare tumor entity and is not the focus of major research activities although an increasing incidence has to be noticed. registry data on 67 males diagnosed and treated for breast carcinoma during the period 1985-2005 in the metropolitan area of leipzig were retrospectively analyzed. the median age at diagnosis was 65 years (39-92 years) with an incidence peak in the age group 60-70 years. according to the tnm classification a carcinoma in situ was diagnosed in ... | 2007 | 17907079 |
| split gfp complementation assay: a novel approach to quantitatively measure aggregation of tau in situ: effects of gsk3beta activation and caspase 3 cleavage. | to quantitatively measure tau aggregation in situ, we established a cell model system using a split green fluorescence protein (gfp) complementation assay. in this assay the more aggregated the protein of interest the lower the gfp fluorescence. tau microtubule-binding domain constructs, whose aggregation characteristics have been described previously (khlistunova et al. 2006), were used to validate the assay. the aggregation-prone construct exhibited the lowest gfp intensity whereas the aggrega ... | 2007 | 17908237 |
| t3/t4 thoracic sympathictomy and compensatory sweating in treatment of palmar hyperhidrosis. | compensatory sweating (cs) is one of the most common postoperative complications after thoracic sympathectomy, sympathicotomy or endoscopic sympathetic block (esb) for palmar hyperhidrosis. this study was conducted to examine the relevance between cs and the sympathetic segment being transected in the surgical treatment of palmar hyperhidrosis, and thus to detect the potential mechanism of the occurrence of cs. | 2007 | 17908472 |
| experimental hyperthyroidism increases expression of parathyroid hormone-related peptide and type-1 parathyroid hormone receptor in rat ventricular myocardium of the langendorff ischaemia-reperfusion model. | parathyroid hormone-related peptide (pthrp) is released under ischaemic conditions and it improves contractile function of stunned myocardium. the actions of pthrp are mediated primarily by the type 1 parathyroid hormone receptor (pth.1r), while pthrp and pth.1r expression levels are increased in ventricular hypertrophy associated with experimental hyperthyroidism. since chronic administration of thyroxine (t4) improves postischaemic recovery in isolated heart models subjected to ischaemia-reper ... | 2008 | 17911357 |
| is there any prognostically different subgroup among patients with stage iiic (any tn3m0) breast carcinoma? | we investigated whether there are prognostically different subgroups among patients with stage iiic (any tn3m0) breast carcinoma. | 2008 | 17912589 |
| physiological versatility of the genus rhodocista. | a new purple bacterium (strain t4), capable of heterotrophic aerobic and phototrophic anaerobic growth, was isolated from waste water of a noodle factory near hanoi, vietnam. a comparison of 16s rdna sequences revealed its association with the genus rhodocista. the isolate, tentatively named "rhodocista hanoiensis", forms cysts after growth on butyrate-containing plates at 42 degrees c. the vegetative cells form short (under aerobic conditions) or long curve-shaped rods. in contrast to other spe ... | 2007 | 17913074 |
| the ser176 of t4 endonuclease iv is crucial for the restricted and polarized dc-specific cleavage of single-stranded dna implicated in restriction of dc-containing dna in host escherichia coli. | endonuclease (endo) iv encoded by denb of bacteriophage t4 is an enzyme that cleaves single-stranded (ss) dna in a dc-specific manner. also the growth of dc-substituted t4 phage and host escherichia coli cells is inhibited by denb expression presumably because of the inhibitory effect on replication of dc-containing dna. recently, we have demonstrated that an efficient cleavage by endo iv occurs exclusively at the 5'-proximal dc (dc1) within a hexameric or an extended sequence consisting of dc r ... | 2007 | 17913749 |
| thyroxine (t4) transfer from csf to choroid plexus and ventricular brain regions in rabbit: contributory role of p-glycoprotein and organic anion transporting polypeptides. | this study investigated the transfer of t4 from cerebrospinal fluid (csf) into the choroid plexuses (cp) and ventricular brain regions, and the role of p-glycoprotein (p-gp), multidrug resistance protein 1 (mrp1) and organic anion transporting polypeptides (oatps). during in vivo ventriculo-cisternal (v-c) perfusion in the anesthetized rabbit (meditomidine hydrochloride 0.5 mg kg(-1), pentobarbitone 10 mg kg(-1) i.v.), 125i-t4 was perfused continuously into ventricular csf with reference molecul ... | 2007 | 17915195 |
| interleukin-4 induces specific pp-galnac-t expression and alterations in mucin o-glycosylation in colonic epithelial cells. | mucus hypersecretion occurs as a consequence of the th2 immune response in epithelia, yet it was not previously known whether the degree of o-glycosylation was modulated under such conditions. a colonic carcinoma cell line ls174t was used to assess the effect of interleukin (il)-4 on the mrna levels of eight pp-galnac-ts. a three- to four-fold increase in pp-galnac-t1, t4, and t7 levels was observed. lysates of untreated or il-4-treated cells were examined for their ability to transfer galnac re ... | 2008 | 17916404 |