| the prognostic value of carcinoembryonic antigen in t1n1m0 and t2n1m0 non-small cell carcinoma of the lung. | to evaluate the significance of preoperative clinicopathological factors, including serum carcinoembryonic antigen (cea), as well as postoperative clinicopathological factors in t1-2n1m0 patients with non-small cell lung cancer who underwent curative pulmonary resection. | 2007 | 17643308 |
| influence of perioperative hemodynamics on spinal cord ischemia in thoracoabdominal aortic repair. | the purpose of this study is to investigate the influence of perioperative circulation on spinal cord during the repair of descending thoracic or thoracoabdominal aortic aneurysms. | 2007 | 17643620 |
| dosimetric consequences of breath-hold respiration in conformal radiotherapy of esophageal cancer. | the objective of this paper is to study the dosimetric impact of respiratory gated radiotherapy in locally advanced esophageal carcinomaand to define the optimal respiratory phase for this treatment. the study included 8 consecutive patients with squamous-cell carcinoma (scc) or histologically proved adenocarcinoma, for both at least t3-t4 nx or tx n1 m0 stage. informed consent was obtained before beginning the study. three spiral scans were performed in breath-hold respiration: one acquisition ... | 2006 | 17643895 |
| the type 1 insulin-like growth factor receptor is over-expressed in bladder cancer. | to analyse bladder cancer biopsies and investigate the pattern of expression of the type 1 insulin-like growth factor receptor (igf1r), a receptor tyrosine kinase that mediates tumour cell proliferation, motility and protection from apoptosis. | 2007 | 17645417 |
| long-term follow up of patients with invasive bladder carcinoma receiving combined cisplatin-based intra-arterial chemotherapy and radiotherapy. | combined cisplatin-based intra-arterial chemotherapy and radiotherapy is an effective treatment for patients with locally invasive bladder carcinoma. we report long-term follow-up data regarding definitive treatment of locally invasive bladder carcinoma, regardless of whether bladder preservation was possible. | 2007 | 17645599 |
| [factors affecting the prognosis and selection of local excision for low rectal cancer]. | to investigate the factors affecting the result and selection of local excision for low rectal cancer. | 2007 | 17645854 |
| results of the 1999 2001 japanese patterns of care study for patients receiving definitive radiation therapy without surgery for esophageal cancer. | the third japanese patterns of care study (jpcs) was conducted for esophageal cancer patients receiving radiotherapy (rt). the aim of this study is to analyse the data of the non-surgery group. | 2007 | 17646277 |
| assessment of alterations in regional cerebral blood flow in patients with hypothyroidism due to hashimoto's thyroiditis. | the aim of this study was to assess regional cerebral blood flow (rcbf) using detailed semiquantitative analysis of technetium-99m hexamethylpropyleneamine (hmpao) brain single-photon emission computerized tomography (spect) in patients with hypothyroidism due to autoimmune thyroiditis. | 2007 | 17646724 |
| definitive conformal radiotherapy for localized high-risk prostate cancer: a long-term follow-up study with psa course. | the present study investigated the long-term outcome of patients with localized high-risk prostate cancer after definitive conformal radiotherapy. | 2007 | 17649783 |
| subclinical thyroid disorders--consequences and implications for treatment. | subclinical hyperthyroidism is characterized by low circulating tsh concentrations, together with normal concentrations of free t4 and free t3. the clinical significance of low but detectable tsh values is likely to be different from undetectable tsh values. the question remains as to whether endogenous and exogenous (iatrogenic) causes of low serum tsh have the same clinical significance. subclinical hypothyroidism is characterized by high serum tsh concentrations, together with normal free t4 ... | 2007 | 17651685 |
| autism: transient in utero hypothyroxinemia related to maternal flavonoid ingestion during pregnancy and to other environmental antithyroid agents. | the incidence and prevalence of autism have increased during the past two decades. despite comprehensive genetic studies the cause of autism remains unknown. this review emphasizes the potential importance of environmental factors in its causation. alterations of cortical neuronal migration and cerebellar purkinje cells have been observed in autism. neuronal migration, via reelin regulation, requires triiodothyronine (t3) produced by deiodination of thyroxine (t4) by fetal brain deiodinases. exp ... | 2007 | 17651757 |
| effects of a 5-day treatment with the uv-filter octyl-methoxycinnamate (omc) on the function of the hypothalamo-pituitary-thyroid function in rats. | octyl-methoxycinnamate (omc) is one of the most frequently used uv-filters in sunscreens to protect the skin against the noxious influence of uv radiation. recently, omc was suspected to act as an "endocrine active chemical" (eac) with estrogenic actions. while eacs have been investigated thoroughly for interference with reproductive function in mammalians, surprisingly little efforts have been made to investigate an interference of eacs with the hypothalamo-pituitary-thyroid (hpt) axis despite ... | 2007 | 17651886 |
| effects of urinary protease inhibitor on inflammatory response during on-pump coronary revascularisation. effect of ulinastatin on inflammatory response. | cardiac surgery in patients undergoing cardiopulmonary bypass (cpb) provokes a vigorous inflammatory response with substantial clinical implications. once the inflammatory response is triggered by cpb, leukocytes and platelets are activated by multiple stimuli. the administration of a urinary trypsin inhibitor (ulinastatin) during cpb is hypothesized to reduce cytokine release and platelet activation and to decrease pulmonary injury. we performed a prospective randomized study to investigate the ... | 2007 | 17653011 |
| advanced gallbladder cancer: indian "middle path". | gallbladder cancer (gbc) is common in northern india. the western world has a pessimistic attitude towards gbc resulting in inadequate management of even early gbc. at the other extreme is the japanese aggressivism with high mortality but very few actual long-term survivors. the indian surgeons have adopted a buddhist "middle path"--aggressive surgical approach for "less advanced" gbc and non-surgical palliative approach for "more advanced" gbc. we rely heavily on staging laparoscopy to detect m ... | 2007 | 17653634 |
| temperature dependence of thermodiffusion in aqueous suspensions of charged nanoparticles. | measurements of particle flows driven by temperature gradients are conducted as a function of temperature on aqueous suspensions of polystyrene nanoparticles and proteins of t4 lysozyme and mutant variants of t4 lysozyme. the thermodiffusion coefficients are measured using a microfluidic beam deflection technique on suspensions with particle concentrations on the order of 1 vol %. at t < or ~ 20 degrees c, all of the nanoparticles studied migrate to the hot regions of the fluid; i.e., the thermo ... | 2007 | 17655335 |
| risk factors for para-aortic lymph node metastasis of gastric cancer from a randomized controlled trial of jcog9501. | no risk factor has been confirmed for para-aortic lymph node (pan) metastasis from gastric cancer. to identify the risk factors and the most frequent route of metastasis to pan, we analyzed the prospective data from a phase iii trial. | 2007 | 17656480 |
| [a case of upper gastrointestinal bleeding and paraplegia]. | lymphoma is a systemic disease. it is not uncommon to be found involved in digestive or central nervous system. however, lymphoma involved in these two systems at the same time is rare. the clinical feature of a case of lymphoma with gastrointestinal bleeding and limbs weakness was investigated and the literature was reviewed. the patient came to our hospital with melena and hematemesis. she was diagnosed as gastric ulcer by gastroscopy and biopsy showed lymphoma. two days after she came to hosp ... | 2007 | 17657279 |
| plasmid vectors for testing in vivo promoter activities in corynebacterium glutamicum and rhodococcus erythropolis. | novel shuttle promoter-probe vectors replicating in escherichia coli, corynebacterium glutamicum, and rhodococcus erythropolis were constructed on the basis of the c. glutamicum plasmid pcg1. the vectors carry reporter genes coding for fluorescent proteins, which allow the measurement of promoter activities in vivo. the promoter-probe vector ppre11 contains the rsgfp reporter gene, coding for a variant of green fluorescent protein (gfp) with a red-shifted excitation maximum. to ensure efficient ... | 2007 | 17657537 |
| [erythrocyte carbonic anhydrase i and zinc concentrations in thyrotoxicosis reflect integrated thyroid hormone levels over the previous few months]. | in the present review, the clinical utility of determining red blood cell (rbc) carbonic anhydrase i isozyme (ca1) and zinc(zn) concentrations in patients with various forms of thyroid disease is discussed. rbc cai and zn concentrations were both decreased in patients with hyperthyroid graves' disease. after treatment, the normalization of rbc ca1 and zn lagged two months behind the normalization of plasma thyroxine (t4) and triiodothyronine (t3) levels. furthermore, the highest correlation coef ... | 2007 | 17657991 |
| acute variation in cognitive function in hemodialysis patients: a cohort study with repeated measures. | although cognitive function in hemodialysis patients is believed to be best 24 hours after the dialysis session, the extent of variation during the dialysis cycle is unknown. | 2007 | 17660028 |
| alterations in the two globular domains or in the connecting alpha-helix of bacterial ribosomal protein l9 induces +1 frameshifts. | the ribosomal 50s subunit protein l9, encoded by the gene rpli, is an elongated protein with an alpha-helix connecting the n- and c-terminal globular domains. we isolated rpli mutants that suppress the +1 frameshift mutation hisc3072 in salmonella enterica serovar typhimurium. these mutants have amino acid substitutions in the n-terminal domain (g24d) or in the c-terminal domain (i94s, a102d, g126v, and f132s) of l9. in addition, different one-base deletions in rpli altered either the final port ... | 2007 | 17660285 |
| [the reaction of hormones of hypophysis-thyroid gland's endocrinal axis on vibration pathology and on condition of it's correction with liquid oxygen and anabolic steroids]. | the experiment was held on white male rats. after the tests had been finished, by means of immunofermental method the concentration of thyroid (t3 and t4) and thyrotrophic (tsh) hormones were defined in the blood of animals in condition of vibropathology and it's correction with liquid oxygen and retabolil. the research showed, that the level of tsh, t3 and t4 decreased in condition of vibropathology and it's correction with anabolic steroid compare with control groups. but against of background ... | 2007 | 17660607 |
| pancreatic and duodenal invasion in distal bile duct cancer: paradox in the tumor classification of the american joint committee on cancer. | distal bile duct cancer often invades the pancreas and/or duodenum. invasion of the pancreas is defined as a t3 and that of the duodenum as a t4 tumor in the t classification of the american joint committee on cancer (ajcc). the aim of this study was to assess whether this t classification is rational from the viewpoint of prognostic power. | 2007 | 17661132 |
| quality control of endoscopic ultrasound in preoperative staging of esophageal cancer. | endoscopic ultrasonography (eus) is generally established as the most sensitive diagnostic tool for the assessment of locoregional tumor stage in esophageal carcinoma. it therefore has a crucial impact on the decision whether patients should undergo surgery as primary treatment or should receive neoadjuvant therapy. this study retrospectively evaluates the accuracy of eus in tumor and nodal staging of prospectively evaluated patients with esophageal carcinoma in relation to tumor type, tumor gra ... | 2007 | 17661247 |
| heart failure after aortic valve substitution due to severe hypothyroidism. | we report a case of a 70-year-old female with considerable co-morbidities (type 2 diabetes, leiden factor v mutation, mild to moderate chronic obstructive pulmonary disease) and a recent biological aortic valve substitution, who was admitted due to circulatory collapse caused by severe heart failure with an ejection fraction of 10%. the patient was treated with diuretics and inotropic drugs with only a minor effect on the condition. a thyroid status disclosed a condition of overt hypothyreosis ( ... | 2008 | 17662492 |
| thyroid autoimmunity in children and adolescents with type 1 diabetes mellitus: prevalence and risk factors. | studies show great variation in prevalence of anti-thyroid antibodies in children with type 1 diabetes mellitus (dm1). there still is no consensus regarding screening of autoimmune thyroiditis in patients with dm1, especially in asymptomatic patients. | 2007 | 17663291 |
| survival of breast cancer patients. our experience. | life expectancy for patients with breast carcinoma has changed in europe over the last two decades. in italy, the overall survival rate is about 77% at 5 years. when considering the situation in sicily, the eurocare 2 study examined survival data from the ragusa cancer registry, showing that the curves are worse than in other regions of italy. starting from these considerations we decide to evaluate whether these data from the ragusa cancer registry corresponded to palermo data. so we analysed d ... | 2007 | 17663369 |
| the burden of stroke scale (boss) provided valid, reliable, and responsive score estimates of functioning and well-being during the first year of recovery from stroke. | to examine the reliability, validity, and responsiveness of the burden of stroke scale (boss). | 2007 | 17665314 |
| prognostic impact of pcr-based identification of isolated tumour cells in the peritoneal lavage fluid of gastric cancer patients who underwent a curative r0 resection. | identification of cancer cells in the peritoneal cavity could influence therapy and outcome of gastric carcinoma patients. the objective of this study was to evaluate the clinical impact of the real-time quantitative polymerase chain reaction-(pcr) based identification of isolated tumour cells in the peritoneal lavage fluid of gastric carcinoma. the peritoneal lavage fluid of 116 patients with gastric cancer was sampled at laparotomy. after rna extraction and reverse transcription, real-time qua ... | 2007 | 17667927 |
| blood-brain barrier genomics and cloning of a novel organic anion transporter. | a novel organic anion transporter selectively expressed at the blood-brain barrier (bbb), originally designated bbb-specific anion transporter type 1 (bsat1), and now classified as slco1c1, has been cloned from a bbb genomics program as a partial cdna; this study describes the cloning and expression of the full-length cdna from a rat brain capillary cdna library. northern analysis revealed the selective expression of the transporter at the bbb, and the transporter was expressed after permanent t ... | 2008 | 17667996 |
| the prevalence of elevated serum thyroid-stimulating hormone in childhood/adolescent obesity and of autoimmune thyroid diseases in a subgroup. | 1) to ascertain the frequency of elevated thyroid-stimulating hormone (tsh) level in obese children and adolescents and 2) to determine the prevalence of positive thyroid antibodies in the subgroup of obese children with elevated serum tsh concentration. | 2007 | 17668643 |
| matrix metalloproteinase-9 activity is associated with poor prognosis in t3-t4 node-negative colorectal cancer. | reversion-inducing cysteine-rich protein with kazal motifs (reck) is a novel membrane-anchored matrix metalloproteinase (mmp) inhibitor. reck, mmp-2, and mmp-9 are believed to play crucial roles in tumor progression. this study was designed to examine the prognostic value of reck, mmp-2, and mmp-9 in conjunction with other clinicopathologic factors in patients of t3-t4 node-negative colorectal cancer. reck and mmp expression was observed using immunohistochemical analysis of the primary tumor fr ... | 2007 | 17669467 |
| prevention of suckling improves postpartum reproductive responses to hormone treatments in pelibuey ewes. | to determine the effects of suckling on postpartum (pp) reproductive efficiency in pelibuey ewes, two experiments were performed. in experiment 1, 112 ewes were randomly assigned to one of two groups at parturition: without restriction of suckling (wrs) 24 h day(-1) for 60 days (n=56), and weaned ewes (we), weaned at 40 days pp (n=56). on day 30 pp, all ewes were given prostaglandin (pgf2alpha) and one of four treatments (n=14): t1, intravaginal progestagen (fga; 40 mg) for 12 days from day 30 p ... | 2008 | 17669607 |
| fast-track approach in abdominal aortic surgery: left subcostal incision with blended anesthesia. | the introduction of fast-tracking multidisciplinary programs allows good results in postoperative outcome in many surgical specialties. we evaluated a multimodal clinical program (based on mininvasive surgery, epidural anesthesia and early mobilization and feeding) in abdominal aortic surgery. | 2007 | 17669770 |
| measurement of troponin t and i to detect cardioprotective effect of aminophylline during coronary artery bypass grafting. | the aim of the present study was to evaluate the possibility that aminophylline could serve as a potential myocardial protectant by measuring cardiac troponin t (tnt) and troponin i (tni) during coronary artery bypass grafting (cabg). twenty patients were randomly divided into two groups. ten patients received aminophylline, 200 mg orally per day for 3 days preoperatively (aminophylline group, ag), and 10 patients received placebo (control group, cg). blood samples were collected before inductio ... | 2003 | 17670055 |
| invasive staging of superior mediastinum in non-small cell lung cancer patients with specific indications. | this prospective study was done between february 2001 and december 2002 on 84 non-small cell lung cancer patients who were apparently operable. we selectively performed mediastinoscopy to 46 patients (54.76%, group 1) with the following indications: clinical t4 tumor, high operative risk, radiologically enlarged mediastinal lymph nodes, clinical t3 tumors with central location, radiologically identified mediastinal lymph nodes of any size with adeno or large cell carcinoma histology. other 38 pa ... | 2003 | 17670098 |
| [expression and clinical significance of survivin and livin in dukesob colorectal cancer]. | survivin and livin, members of the family of inhibitor of apoptosis proteins (iaps), are specially expressed in embryonic cells and tumor cells, but are seldom expressed in normal adult cells. some studies showed that they are correlated to poor prognosis of some tumors. this study was to detect the expression of survivin and livin in dukesob colorectal cancer, and analyze the clinical significance. | 2007 | 17672950 |
| complete genomic sequence and mass spectrometric analysis of highly diverse, atypical bacillus thuringiensis phage 0305phi8-36. | to investigate the apparent genomic complexity of long-genome bacteriophages, we have sequenced the 218,948-bp genome (6479-bp terminal repeat), and identified the virion proteins (55), of bacillus thuringiensis bacteriophage 0305phi8-36. phage 0305phi8-36 is an atypical myovirus with three large curly tail fibers. an accurate mode of dna pyrosequencing was used to sequence the genome and mass spectrometry was used to accomplish the comprehensive virion protein survey. advanced informatic techni ... | 2007 | 17673272 |
| low serum selenium concentration as a possible factor for persistent goiter in iranian school children. | selenium deficiency can have adverse effect on thyroid metabolism and response to iodine supplementation. the aim of this study was to determine relationship between prevalence of goiter, thyroid hormone profile, urinary iodine and serum selenium concentrations in iranian schoolchildren. in a cross- sectional study, 1188 schoolchildren in the age group of 8-13 years were evaluated for goiter prevalence. urine and serum samples were collected from 500 children and assayed for urinary iodine conce ... | 2007 | 17673823 |
| the effect of the mode of delivery on neonatal thyroid function. | we aimed to investigate the effect of the mode of delivery and the type of anesthesia on postnatal thyroxine (t4), free t4 (f-t4) and thyroid-stimulating hormone (tsh) in a large number of healthy full-term neonates. | 2007 | 17674257 |
| [expression and significance of tyrosine kinase receptors b in nasopharyngeal carcinoma patients]. | this study was to explore the expression and clinicopathologic features of tyrosine kinase receptors b (trkb) and its ligand brain-derived neurotrophic factor (bdnf) in nasopharyngeal carcinoma (npc). | 2007 | 17674765 |
| [experimental study on bladder cancer by the small interfering rna targeting survivin]. | to study the influence of small interfering rna (sirna) targeting survivin on the biological behavior of bladder cancer. | 2007 | 17680529 |
| current relevance of cervical ultrasonography in staging cancer of the esophagus and gastroesophageal junction. | to evaluate the value of external ultrasonography (us) of the neck in current dedicated preoperative staging of patients with cancer of the esophagus and gastroesophageal junction (gej). | 2008 | 17681735 |
| haemato-immunological responses to dietary yeast rna, omega-3 fatty acid and beta-carotene in catla catla juveniles. | a preliminary study with 60 days feeding was conducted to study the immunomodulatory role of different immunostimulants like beta-carotene, omega-3 fatty acid and yeast-rna in catla catla fingerlings. two hundred and sixty four fingerlings were randomly distributed into eight treatment groups with each of three replicates. eight isonitrogenous (crude protein 34.12-35.40%) and isocaloric (458.41-461.48 kcal/100g) purified diets were prepared with graded level of beta-carotene, omega-3 fatty acid ... | 2007 | 17681812 |
| effect of supplementation of dietary protected lipids on intake and nutrient utilization in deccani lambs. | four complete isonitrogenous (crude protein 13%) rations with 0 (t1), 5 (t2), 10 (t3) and 15 (t4) per cent calcium soap from red palm oil (protected fat) were formulated and evaluated using four deccani lambs (19.32 +/- 0.82 kg) in a completely randomized design at the end of a growth trial. the average daily dry matter intake (% body weight or g/kg w0.75 per day) in lambs fed ration t4 was significantly (p < 0.05) lower than in those fed rations t1, t2, and t3. there was no significant differen ... | 2006 | 17682600 |
| [vertebral fracture assessed by dxa: a new risk factor for fracture]. | at the age of 50, a woman has a lifetime risk of more than 40% to present a vertebral fracture. more than 60% of vertebral fractures remain undiagnosed. as a consequence it is of major importance to develop screening strategies to detect these fractures. vertebral fracture assessment (vfa) by dxa allows one to detect vertebral fracture from t4 to l4 using dxa devices, while performing also during the same visit the bone mineral density measurement. such an approach should improve the evaluation ... | 2007 | 17682791 |
| does "clinical" r0 have validity in the choice of simple cholecystectomy for gallbladder carcinoma? | this study was designed to evaluate the survival outcomes of patients undergoing simple cholecystectomy and to investigate which patients would benefit from cholecystectomy alone in treating gallbladder carcinoma. | 2007 | 17682825 |
| [efficiency of coenzyme q(10) at experimental spinal cord injury]. | in this study, we aimed to compare the efficacy of methylprednisolone, coenzyme q(10) and combined methylprednisolone and coenzyme q(10) treatments on experimental spinal cord injury. | 2007 | 17682949 |
| [effect of axial loading on bone mineral density in patients with traumatic spinal cord injury]. | osteoporosis occurs in paralyzed extremities secondary to immobilization following spinal cord injury (sci). bone mineral density (bmd) is rapidly lost after sci. loss of bmd may reach fracture threshold although it slows with time. this study was planned to investigate the option of impediment of osteoporosis by early axial loading in immobilized patients. | 2007 | 17682951 |
| quantitative analysis of thyroid-stimulating hormone messenger rna and heterogeneous nuclear rna in hypothyroid rats. | thyroid-stimulating hormone (tsh) stimulates the synthesis and release of thyroid hormones including triiodothyronine (t3) and thyroxine (t4). semiquantitative analyses using northern blot and in situ hybridization suggested that tsh gene transcription is upregulated under conditions of hypothyroidism. however, no quantitative analysis of tsh gene expression using real-time polymerase chain reaction (pcr) has been reported. in this study, we quantitated the tshbeta messenger ribonucleic acid (mr ... | 2007 | 17683800 |
| triiodothyronine differentially regulates key metabolic factors in lean and obese cats. | the effect of a 2-week administration of 75microg triiodothyronine (t3) on substrate oxidation, heat production, non-esterified fatty acids, and leptin was evaluated in eight lean (three females and five males) and eight obese (five females and three males) age-matched adult neutered cats. in addition, using real-time rt-pcr, expression of muscle and adipose tissue uncoupling proteins (ucp2 and ucp3), deiodinase 1 and 2 (d1; d2), and peroxisome proliferator-activated receptor (ppar) alpha and ga ... | 2008 | 17683895 |
| ontogenesis of thyroid function and interactions with maternal function. | fetal and neonatal development of thyroid function involves the embryogenesis, differentiation and maturation of the thyroid gland, of the hypothalamic-pituitary-thyroid axis and of the systems controlling thyroid hormone metabolism. we focus here on aspects related to neurodevelopment. throughout gestation, thyroxine (t4) transferred from the mother, present in embryonic fluids by 4 weeks, protects the fetal brain. free t4 (ft4) in fetal fluids increases rapidly, approaching adult levels by mid ... | 2007 | 17684391 |
| thyroid hormone transporter defects. | in in vitro experiments, active transport of thyroid hormones had been repeatedly demonstrated. the membrane transporters for thyroid hormones which have been identified include the organic anion transporting polypeptide, heterodimeric amino acid transporters and the monocarboxylate transporters (mct) which are the focus of this chapter. the gene encoding mct8 which was identified as a specific thyroid hormone transporter is located on chromosome xq13.2. the expression pattern of mct8 indicates ... | 2007 | 17684393 |
| novel biological and clinical aspects of thyroid hormone metabolism. | intracellular metabolism of thyroid hormone (th) and availability of the active hormone t3 is regulated by three selenoprotein iodothyronine deiodinases (ds). d1 and d2 convert the precursor t4 into the active hormone, t3. d3 is the principal inactivator of t4 and t3 to their respective metabolites, rt3 and t2. while acquired changes in d activities are common, inherited defects in humans were not known. recently, two families with abnormal thyroid function tests, high serum t4, high rt3, low t3 ... | 2007 | 17684394 |
| [hyperlipidemias and dietary patterns: transversal study of japanese brazilians]. | this study aimed at evaluating the association between hyperlipidemia and dietary patterns of japanese brazilians with and without hypothyroidism from bauru, city in the state of são paulo. we evaluated 1,330 individuals by means of demographic and dietary measurement, whom were gotten through standardized questionnaires previously tested. clinical examination and laboratory data were anthropometry, blood pressure, fasting and 2-h glucose load, lipid profile and tsh and free t4. the chi-square a ... | 2007 | 17684615 |
| are neuropsychological changes relevant in subclinical hypothyroidism? | neuropsychological changes are still controversial in patients with subclinical hypothyroidism (sh). the objective of this study is to assess these changes. | 2007 | 17684623 |
| supraglottic laryngectomy: analysis of 267 cases. | horizontal supraglottic laryngectomy (hsl) allows the preservation of a functioning larynx and avoids permanent tracheotomy. in this retrospective study we report our experience with hsl and describe the functional and oncological results of the procedure. a total of 267 previously untreated patients with squamous cell carcinoma of the supraglottis underwent a supraglottic laryngectomy at our department from january 1978 to may 2002. the main outcome measures were: local and regional control, di ... | 2008 | 17684753 |
| long-term stability of surgical mandibular setback. | to test the relationship between positional changes of the proximal segments during surgery and the positional rebound of the mandible during the postsurgical period of orthodontic treatment. | 2007 | 17685766 |
| [efficacy of neoadjuvant radiochemotherapy in treatment of locally advanced low rectal cancer]. | to explore efficacy of neoadjuvant radiochemotherapy in locally advanced low rectal cancer. | 2007 | 17686297 |
| t4 dna ligase is more than an effective trap of cyclized dsdna. | t4 dna ligase is used in standard cyclization assays to trap double-stranded dna (dsdna) in low-probability, cyclic or highly bent conformations. the cyclization probability, deduced from the relative yield of cyclized product, can be used in conjunction with statistical mechanical models to extract the bending stiffness of dsdna. by inserting the base analog 2-aminopurine (2-ap) at designated positions in 89 bp and 94 bp dsdna fragments, we find that t4 dna ligase can have a previously unknown ... | 2007 | 17686784 |
| parental consanguinity among parents of neonates with congenital hypothyroidism in isfahan. | we determined the prevalence of congenital hypothyroidism and the rate of consanguin-ity among parents of hypothyroid neonates among 93 381 neonates born in 17 hospitals in isfahan from may 2002 to april 2005. serum thyroxine (t4) and thyroid stimulating hormone (tsh) levels were measured on the 3rd-7th day of birth and neonates with abnormal levels were recalled and the levels reassessed. those with tsh > or = 10 mlu/l and t4 < 6.5 microg/dl on the second assay were considered hypothyroid. in a ... | 2007 | 17687829 |
| twin pregnancy with a coexisting hydatiform mole and liveborn infant: complicated by maternal hyperthyroidism and neonatal hypothyroidism. | a twin pregnancy with a coexisting complete hydatiform mole and a healthy fetus is rare. associated with this condition are potentially serious maternal and fetal complications. we describe a case of a woman, 23/40 pregnant, who was diagnosed with a twin pregnancy complicated by a hydatiform mole, vaginal bleeding, hyperthyroidism and preterm labour at 26/40. her hyperthyroidism was successfully treated with propylthiouracil. the preterm labour resulted in the livebirth of a healthy male infant. ... | 2007 | 17688651 |
| hypnosis in the management of persistent idiopathic orofacial pain--clinical and psychosocial findings. | this controlled and patient blinded study tested the effect of hypnosis on persistent idiopathic orofacial pain (piop) in terms of clinical and psychosocial findings. forty-one piop were randomized to active hypnotic intervention or simple relaxation as control for five individual 1-h sessions. primary outcome was average pain intensity scored three times daily in a pain diary using visual analogue scale (vas). secondary outcome measures were pain quality assessed by mcgill pain questionnaire (m ... | 2008 | 17689192 |
| l-t4 and l-t3 combined treatment vs l-t4 alone. | | 2007 | 17689474 |
| effects of thyroid hormones on memory and on na(+), k(+)-atpase activity in rat brain. | thyroid hormones (ths), including triiodothyronine (t3) and tetraiodothyronine (t4), are recognized as key metabolic hormones of the body. ths are essential for normal maturation and function of the mammalian central nervous system (cns) and its deficiency, during a critical period of development, profoundly affects cognitive function. sodium-potassium adenosine 5'-triphosphatase (na(+), k(+)-atpase) is a crucial enzyme responsible for the active transport of sodium and potassium ions in the cns ... | 2007 | 17691972 |
| crystal structure of bacteriophage t4 5' nuclease in complex with a branched dna reveals how flap endonuclease-1 family nucleases bind their substrates. | bacteriophage t4 rnase h, a flap endonuclease-1 family nuclease, removes rna primers from lagging strand fragments. it has both 5' nuclease and flap endonuclease activities. our previous structure of native t4 rnase h (pdb code 1tfr) revealed an active site composed of highly conserved asp residues and two bound hydrated magnesium ions. here, we report the crystal structure of t4 rnase h in complex with a fork dna substrate bound in its active site. this is the first structure of a flap endonucl ... | 2007 | 17693399 |
| genome analysis of phage js98 defines a fourth major subgroup of t4-like phages in escherichia coli. | numerous t4-like escherichia coli phages were isolated from human stool and environmental wastewater samples in bangladesh and switzerland. the sequences of the major head gene (g23) revealed that these coliphages could be placed into four subgroups, represented by the phages t4, rb69, rb49, and js98. thus, js98 defines a new major subgroup of e. coli t4-like phages. we conducted an analysis of the 169-kb js98 genome sequence. overall, 198 of the 266 js98 open reading frames (orfs) shared amino ... | 2007 | 17693496 |
| the t4 ri antiholin has an n-terminal signal anchor release domain that targets it for degradation by degp. | lysis inhibition (lin) of t4-infected cells was one of the foundational experimental systems for modern molecular genetics. in lin, secondary infection of t4-infected cells results in a dramatically protracted infection cycle in which intracellular phage and endolysin accumulation can continue for hours. at the molecular level, this is due to the inhibition of the holin, t, by the antiholin, ri. ri is only 97 residues and contains an n-terminal hydrophobic domain and a c-terminal hydrophilic dom ... | 2007 | 17693511 |
| patient selection, cancer control, and complications after salvage local therapy for postradiation prostate-specific antigen failure: a systematic review of the literature. | among men who experience prostate-specific antigen (psa) failure after external beam radiation or brachytherapy (rt), many will harbor occult micrometastases; however, a significant minority will have a true local-only failure and, thus, potentially may benefit from a salvage local therapy. those most likely to have a local-only failure initially have low-risk disease (psa < 10 ng/ml, gleason score < or =6, clinical t1c or t2a tumor status), pretreatment psa velocity < 2.0 ng/ml per year at the ... | 2007 | 17694553 |
| [construction of recombinant adeno-associated virus vector with human bone morphogenetic protein]. | to construct the recombinant adeno-associated virus vector with human bone morphogenetic protein 4 gene (aav-hbmp-4). | 2007 | 17694667 |
| reduced thyrotropin in euthyroid goitrous patients suggesting subclinical hyperthyroidism. | subclinical hyperthyroidism, a biochemical finding of low serum thyrotropin (tsh) with the serum levels of thyroxine (t4) and triiodothyronine (t3) within the reference range, could easily be ignored by clinicians, as it, usually, does not manifest with any thyroid specific symptoms. it is of two types: endogenous and exogenous. however, patients with the findings of low tsh, normal t4 and t3 develop some abnormalities in the cardiovascular system, such as atrial fibrillation, increase in left v ... | 2007 | 17694766 |
| screening procedure to assess the impact of urban stormwater temperature to populations of brown trout in receiving water. | the discharge of urban stormwater may cause a sudden temperature increase in receiving waters that may be harmful to fish and other aquatic organisms. a screening procedure is proposed with temperature thresholds for the runoff from roofs and roads as well as for the receiving water system to protect brown trout from thermal damage. the stormwater temperature is calculated on the basis of a simple thermodynamic estimate for different latitudes. only receiving waters with maximum daily mean tempe ... | 2007 | 17695111 |
| exemestane as neoadjuvant hormonotherapy for locally advanced breast cancer: results of a phase ii trial. | neoadjuvant hormonotherapy has recently been used for downstaging large or locally advanced (la) breast cancer in postmenopausal women. | 2007 | 17695434 |
| survivin expression predicts early recurrence in early-stage breast cancer. | the apoptosis inhibitor survivin is one of the most specific proteins in breast cancer patients. the role of this protein in predicting prognosis is still controversial. | 2007 | 17695451 |
| assessment of t staging and mesorectal fascia status using high-resolution mri in rectal cancer with rectal distention. | to determine the accuracy of high-resolution magnetic resonance imaging (mri) using phased-array coil for preoperative assessment of t staging and mesorectal fascia infiltration in rectal cancer with rectal distention. | 2007 | 17696238 |
| cardiovascular effects of mild hypothyroidism. | the cardiovascular risk is increased in patients with overt hypothyroidism, and several potential cardiovascular risk factors were similarly reported in patients with subclinical hypothyroidism. only recently have more data become available about the effects of mild hypothyroidism on the cardiovascular system. an impaired left ventricular diastolic function, which is characterized by slowed myocardial relaxation and impaired ventricular filling, is the most consistent cardiac abnormality in pati ... | 2007 | 17696831 |
| emmprin and fascin overexpression associated with clinicopathologic parameters of pancreatobiliary adenocarcinoma in chinese people. | the aim of this study was to test whether expression of emmprin and fascin correlates with clinicopathologic parameters of pancreatobiliary adenocarcinoma. immunohistochemical analysis of emmprin and fascin was performed in 100 surgical specimens obtained from chinese patients, including 18 well-differentiated, 62 moderately differentiated, and 20 poorly differentiated pancreatic and biliary adenocarcinomas. neither emmprin nor fascin was detectable in normal pancreatic and biliary glandular epi ... | 2007 | 17696949 |
| [primary non-hodgkin's lymphoma of the paranasal sinuses: a report of 14 cases]. | primary paranasal sinus lymphoma (ppsl) is a rare presentation of extranodal non-hodgkin's lymphoma with a natural history distinct from other lymphomas. this study was to evaluate the clinical and pathologic characteristics, treatment outcomes and prognosis of ppsl. | 2007 | 17697560 |
| oxidative stress biomarkers responses to physical overtraining: implications for diagnosis. | overtraining syndrome is characterized by declining performance and transient inflammation following periods of severe training with major health implications for the athletes. currently, there is no single diagnostic marker for overtraining. the present investigation examined the responses of oxidative stress biomarkers to a resistance training protocol of progressively increased and decreased volume/intensity. twelve males (21.3+/-2.3 years) participated in a 12-week resistance training consis ... | 2007 | 17697935 |
| developmental exposure to decabromodiphenyl ether (pbde 209): effects on thyroid hormone and hepatic enzyme activity in male mouse offspring. | decabrominated diphenyl ether (pbde 209) is the second most used brominated flame retardant (bfrs). many studies have shown that some of the bfrs act as endocrine disruptors via alterations in thyroid hormone homeostasis and affect development. little is known about the effect of prenatal exposure to pbde 209 on the development in male offspring. using a cd-1 mouse model, we attempt to estimate the possible effect of in utero exposure to pbde 209 on thyroid hormone and hepatic enzymes activities ... | 2008 | 17698168 |
| in vivo stabilization of mutant human transthyretin in transgenic mice. | transthyretin (ttr) is a 55 kd homotetrameric serum protein transporter of retinol binding protein charged with retinol and thyroxine (t4). the highly amyloidogenic human ttr variant in which leucine at position 55 is replaced by proline (l55p ttr) is responsible for aggressive fatal amyloidosis with peripheral and autonomic neuropathy, cardiomyopathy and nephropathy. mice bearing one or two copies of a 19.2 kb human genomic fragment containing the entire coding sequence and the known control re ... | 2007 | 17701470 |
| can thyroid dysfunction explicate severe menopausal symptoms? | many of the menopausal manifestations look like those accredited to thyroid hyperfunction or hypofunction. can thyroid dysfunction explicate severe menopausal symptoms? the study comprised 350 women with different menopausal symptoms. all women had serum tsh, t3 and free t4 estimated. women with thyroid dysfunction were appropriately treated and other women were treated with ert. the study showed that 21 women (6%) had hypothyroidism and 18 (5.1%) had hyperthyroidism. marked improvement in the m ... | 2007 | 17701801 |
| urinary tract infection in term neonates with prolonged jaundice. | the aim of this study was to evaluate the frequency of urinary tract infection (uti) in neonates with prolonged jaundice. | 2007 | 17701928 |
| dna polymerase proofreading: active site switching catalyzed by the bacteriophage t4 dna polymerase. | dna polymerases achieve high-fidelity dna replication in part by checking the accuracy of each nucleotide that is incorporated and, if a mistake is made, the incorrect nucleotide is removed before further primer extension takes place. in order to proofread, the primer-end must be separated from the template strand and transferred from the polymerase to the exonuclease active center where the excision reaction takes place; then the trimmed primer-end is returned to the polymerase active center. t ... | 2007 | 17702757 |
| the influence of endoscopic biliary stents on the accuracy of endoscopic ultrasound for pancreatic head cancer staging. | biliary stents have been found to interfere with endoscopic ultrasound (eus) tumor (t) and nodal (n) staging in patients with periampullary cancer. our aim was to determine whether this also occurs in patients with pancreatic head cancer. | 2007 | 17703391 |
| long-term efficacy of preoperative radiotherapy for locally advanced low rectal cancer. | the purpose of this study was to assess the long-term efficacy of preoperative radiotherapy for locally advanced low rectal cancer. | 2008 | 17704925 |
| in vitro evaluation of the disinfection efficacy on eimeria tenella unsporulated oocysts isolated from broilers. | the objective of this study was to evaluate in vitro the action of eight chemical principles by disinfection efficacy (de) of eimeria tenella oocysts. disinfection efficacy was evaluated by either destruction or sporulation inhibition of the oocysts. eight treatments were performed: t1 (glutaraldehyde 42.5 g + benzalkonium chloride 7.5 g); t2 (benzalkonium chloride + quaternary ammonium salt); t3 (formol 37% + sodium dodecylbenzene sulfonate 12%); t4 (sodium hypochlorite 2%); t5 (orthodichlorobe ... | 2007 | 17706006 |
| [construction of bicistronic lentiviral vectors carrying hsv-tk and egfp gene]. | to construct cmv-mediated lentiviral vectors coexpressing egfp and hsv-tk gene in order to establish a novel lentiviral vector platform for the suicide gene therapy of eye disease. | 2007 | 17706084 |
| effects of orlistat therapy on plasma concentrations of oxygenated and hydrocarbon carotenoids. | orlistat is a lipase inhibitor that is applied for treating obesity. lipases are required for digestion and absorption of dietary lipids and fat-soluble vitamins and carotenoids. the aim of this study was to compare the effects of orlistat therapy on plasma concentrations of oxygenated (beta-cryptoxanthin, lutein/zeaxanthin) and hydrocarbon (alpha-, beta-carotene, lycopene) carotenoids. six patients with a body mass index (bmi) > or = 30 kg/m2 received 360 mg/d orlistat over 4.5 mon. plasma caro ... | 2006 | 17707976 |
| correlation of her-2/neu protein overexpression with other prognostic and predictive factors in invasive ductal breast cancer. | the objective of our study was to investigate the association between her-2/neu status and other clinicopathological characteristics of ductal breast carcinoma. | 2007 | 17708365 |
| translational constraint influences dynamic spinal canal occlusion of the thoracic spine: an in vitro experimental study. | mechanical constraints to spine motion can arise in a variety of real-world situations such as when shoulder belts prevent anterior translation of the thorax during automotive collisions. the effect of such constraint on spinal column-spinal cord interaction during injury remains unknown. the purpose of the present study was to compare maximal dynamic spinal canal occlusion, measured via a specialized transducer, in cadaveric upper thoracic spine specimens under a variety of anterior-posterior c ... | 2008 | 17709110 |
| health insurance and stage at diagnosis of laryngeal cancer: does insurance type predict stage at diagnosis? | to examine whether patients with no insurance or medicaid are more likely to present with advanced-stage laryngeal cancer. | 2007 | 17709617 |
| sentinel node biopsy in n0 squamous cell carcinoma of the oral cavity and oropharynx in patients previously treated with surgery or radiation therapy: a pilot study. | to assess the feasibility of sentinel lymph node (sln) localization and to determine the predictive value of sln biopsy for occult neck metastases in patients previously treated with surgery or radiation therapy and with n0 squamous cell carcinoma of the oral cavity or oropharynx. | 2007 | 17709621 |
| potential therapeutic applications of thyroid hormone analogs. | thyroid hormone (t3 and t4) has many beneficial effects including enhancing cardiac function, promoting weight loss and reducing serum cholesterol. excess thyroid hormone is, however, associated with unwanted effects on the heart, bone and skeletal muscle. we therefore need analogs that harness the beneficial effects of thyroid hormone without the untoward effects. such work is largely based on understanding the cellular mechanisms of thyroid hormone action, specifically the crystal structure of ... | 2007 | 17710084 |
| treatment of amiodarone-associated thyrotoxicosis. | a 75-year-old man had a myocardial infarction complicated by poor left ventricular function and non-sustained ventricular tachycardia. he began treatment with amiodarone and 12 months later developed symptoms of thyrotoxicosis. | 2007 | 17710087 |
| thyroid hormone replacement for central hypothyroidism: a randomized controlled trial comparing two doses of thyroxine (t4) with a combination of t4 and triiodothyronine. | dosage of t(4) in central hypothyroidism is primarily guided by the free serum t(4) level (ft4). however, the optimum ft4 range is ill defined, and subtle hypothyroidism might be missed using this approach. | 2007 | 17711927 |
| antitumour and biological effects of letrozole and gnrh analogue as primary therapy in premenopausal women with er and pgr positive locally advanced operable breast cancer. | preoperative endocrine therapy is effective in postmenopausal patients with breast cancers expressing oestrogen receptor. we investigated the activity of primary therapy with letrozole in combination with gnrh analogue in premenopausal women with t2-t4 n0-n2 breast cancer, whose tumours expressed oestrogen and progesterone receptors. we measured the expression of molecular factors involved in responsiveness to endocrine agents including eralpha, egfr, her2, map kinases (and phosphorylated forms) ... | 2007 | 17712311 |
| flexible non-fusion scoliosis correction systems reduce intervertebral rotation less than rigid implants and allow growth of the spine: a finite element analysis of different features of orthobiom. | the orthobiom non-fusion scoliosis correction system consists of two longitudinal rods, polyaxial pedicle screws, mobile and fixed connectors and a cross-connector. the mobile connectors can move along and around the rod, thus allowing length adaptation during growth. the aim of this study was to determine the effects of different features of this novel implant on intervertebral rotations, to calculate the movement of the mobile connectors along the rods for different loading cases and to compar ... | 2008 | 17712575 |
| the effect of high cervical spinal cord stimulation on the expression of sp, nk-1 and trpv1 mrnas during cardiac ischemia in rat. | spinal cord stimulation (scs) is used to reduce angina that accompanies cardiac ischemia, but little is known about the molecular mechanisms mediating this effect. we studied the expression of sp, neurokinin-1 (nk-1) receptor, and transient receptor potential vanilloid type 1 (trpv1) mrna in the rat spinal cord at thoracic 4 (t4), cervical 2 (c2) and caudal brain stem by rt-pcr during intermittent occlusion of the left anterior descending coronary artery (coao), during sustained scs by itself at ... | 2007 | 17714867 |
| high dose rate endorectal brachytherapy as a neoadjuvant treatment for patients with resectable rectal cancer. | in the era of total mesorectal surgery, the issue of radiation toxicity is raised. a novel endocavitary brachytherapy technique was tested as a neoadjuvant treatment for patients with resectable rectal cancer. the objectives of the study were to evaluate the treatment-related toxicity and effects on local recurrence. a dose of 26 gy was prescribed to the gross tumour volume and intramesorectal deposits seen on magnetic resonance imaging and given over four daily treatments, using the high dose r ... | 2007 | 17714925 |