| effects of diet quality on energy budgets and thermogenesis in brandt's voles. | food quality and availability play an important role in an animal's life history. the aim of this study was to examine the effect of diet quality [high-fiber diet (hf) or low-fiber diet (lf)] on energy budgets and thermogenesis in brandt's voles (lasiopodomys (microtus) brandtii). dry matter intake and gross energy intake increased and digestibility decreased in hf voles compared with lf voles, while the digestible energy intake was similar for both hf and lf voles. nonshivering thermogenesis (n ... | 2007 | 17482858 |
| study of prostate cancer pathologic features in chinese populations. | to report the pathologic features of prostate cancer and its clinical outcome in the chinese population in taiwan. | 2007 | 17482934 |
| detecting ultraviolet damage in single dna molecules by atomic force microscopy. | we report detection and quantification of ultraviolet (uv) damage in dna at a single molecule level by atomic force microscopy (afm). by combining the supercoiled plasmid relaxation assay with afm imaging, we find that high doses of medium wave ultraviolet (uvb) and short wave ultraviolet (uvc) light not only produce cyclobutane pyrimidine dimers (cpds) as reported but also cause significant dna degradation. specifically, 12.5 kj/m(2) of uvc and 165 kj/m(2) of uvb directly relax 95% and 78% of p ... | 2007 | 17483180 |
| glucose-6-phosphate dehydrogenase deficiency and kernicterus of south-east anatolia. | we aimed to investigate the rate of kernicterus, and physical and laboratory examination findings in hyperbilirubinemic infants with glucose-6-phosphate dehydrogenase (g-6-pd) deficiency. | 2007 | 17483701 |
| preoperative radiotherapy in elderly patients with rectal cancer. | we performed a retrospective analysis in order to evaluate the compliance with preoperative radiotherapy in patients aged>or=70 with locally advanced resectable rectal cancer, and to evaluate the influence of comorbidities on treatment tolerance and oncological results. | 2007 | 17483785 |
| [intervention of selenium on neurogranin expression in filial cerebrum of mice with excess iodine]. | to study the effects of excess iodine intake on neurogranin expression in cerebrum of filial mice and the intervention of selenium. | 2007 | 17484205 |
| [renal cell carcinoma: prognostic factors and staging]. | to evaluate the prognostic significance of the 2002 tnm tumor classification for renal cell carcinoma, as well as other factors intervening in its survival. | 2007 | 17484480 |
| glycoprotein i of herpes simplex virus type 1 contains a unique polymorphic tandem-repeated mucin region. | glycoprotein i (gi) of herpes simplex virus type 1 (hsv-1) contains a tandem repeat (tr) region including the amino acids serine and threonine, residues that can be utilized for o-glycosylation. the length of this tr region was determined for 82 clinical hsv-1 isolates and the results revealed a polymorphic distribution of two to six or eight repeated blocks with a majority harbouring between two and four repeats. assessment of the o-glycosylation capacity of an acceptor peptide (stpstttstpsttt) ... | 2007 | 17485527 |
| day case breast augmentation under paravertebral blockade: a prospective study of 100 consecutive patients. | an increasing trend toward day surgery management requires plastic surgeons not only to be cognizant of block techniques, but also to assess their safety and efficacy objectively. paravertebral block offers benefits by enhancing surgical anesthesia and postoperative analgesia. this study aimed to assess the safety and efficacy of paravertebral block for day patients undergoing submuscular breast augmentation. the primary outcome measure was the rate of block failure. the secondary outcome measur ... | 2007 | 17486400 |
| reprogramming the trna-splicing activity of a bacterial rna repair enzyme. | programmed rna breakage is an emerging theme underlying cellular responses to stress, virus infection and defense against foreign species. in many cases, site-specific cleavage of the target rna generates 2',3' cyclic phosphate and 5'-oh ends. for the damage to be repaired, both broken ends must be healed before they can be sealed by a ligase. healing entails hydrolysis of the 2',3' cyclic phosphate to form a 3'-oh and phosphorylation of the 5'-oh to form a 5'-po4. here, we demonstrate that a po ... | 2007 | 17488852 |
| c-reactive protein in obese pcos women and the effect of metformin therapy. | elevated c-reactive protein (crp) in association with hyperinsulinemia is a significant risk factor for cardiovascular diseases and that plays a key role in the development of the pcos. we evaluated serum crp level, before and after metformin therapy in obese women with polycystic ovarian syndrome (pcos). thirty five obese women with pcos [bmi=28,2+/-1,84 kg/m2, aged 20-35 years] were studied. patients received metformin orally the dose of 850 mg per day. the patients were carefully interviewed, ... | 2007 | 17489777 |
| [effect of fluid resuscitation on extravascular lung water in early stage of septic shock]. | to determine the effect of fluid resuscitation on extravascular lung water (evlw) in early stage of septic shock. | 2007 | 17490568 |
| upper mediastinal node dissection for hypopharyngeal and cervical esophageal carcinomas. | hypopharyngeal cancer (hpc) and cervical esophageal cancer (ce) are aggressive tumors with a poor prognosis. multiple lymph node metastases often occur in the upper mediastinum, as well as in the neck, and thus upper mediastinal dissection (md) is crucial to improving the cure rate. however, excessive md can increase postoperative morbidity and mortality, making it important to employ the proper technique and appropriate extent of dissection. in the present retrospective study we aimed to determ ... | 2007 | 17491530 |
| structure-function analysis of the 3' phosphatase component of t4 polynucleotide kinase/phosphatase. | t4 polynucleotide kinase/phosphatase (pnkp) exemplifies a family of bifunctional enzymes with 5'-kinase and 3' phosphatase activities that function in nucleic acid repair. t4 pnkp is a homotetramer of a 301-aa polypeptide, which consists of an n-terminal kinase domain of the p-loop phosphotransferase superfamily and a c-terminal phosphatase domain of the dxd acylphosphatase superfamily. the homotetramer is formed via pairs of phosphatase-phosphatase and kinase-kinase homodimer interfaces. here w ... | 2007 | 17493655 |
| successful long-term weight maintenance: a 2-year follow-up. | to find factors associated with successful weight maintenance (wm) in overweight and obese subjects after a very low-calorie diet (vlcd). | 2007 | 17495202 |
| locally advanced cheek carcinoma; radical surgery and reconstruction of though and through defects. | squamous cell carcinoma of the cheek is a locoregionally aggressive tumor. radical resection may be curative in cases of large tumor without distant metastases. we reviewed forty eight consecutive cases of sq.c.c. of the oral cavity to evaluate the feasibility and efficacy of the reconstructive method. | 2006 | 17496939 |
| thermoplastic patient fixation: influence on chest wall and target motion during radiotherapy of lung cancer. | several methods have been developed to reduce tumor motions and patient movements during radiotherapy of lung cancer. in this study, a multislice ct-based analysis was performed to examine the effect of a thermoplastic patient immobilization system on the chest wall and tumor motions. | 2007 | 17497099 |
| ct-based classification of long spinal allograft fusion. | anterior column reconstruction of the thoracolumbar spine by structural allograft has an increased potential for biological fusion when compared to synthetic reconstructive options. estimation of cortical union and trabecular in-growth is, however, traditionally based on plain radiography, a technique lacking in sensitivity. a new assessment method of bony union using high-speed spiral ct imaging is proposed which reflects the gradually increasing biological stability of the construct. grade i ( ... | 2007 | 17497188 |
| probing dna polymerase-dna interactions: examining the template strand in exonuclease complexes using 2-aminopurine fluorescence and acrylamide quenching. | the bacteriophage t4 dna polymerase forms fluorescent complexes with dna substrates labeled with 2-aminopurine (2ap) in the template strand; the fluorescence intensity depends on the position of 2ap. when preexonuclease complexes are formed, complexes at the crossroads between polymerase and exonuclease complexes, 2ap in the +1 position in the template strand is fully free of contacts with the adjacent bases as indicated by high fluorescence intensity and a long fluorescence lifetime of about 10 ... | 2007 | 17497891 |
| identification of a single hnh active site in type iis restriction endonuclease eco31i. | type iis restriction endonuclease eco31i is a "short-distance cutter", which cleaves dna strands close to its recognition sequence, 5'-ggtctc(1/5). previously, it has been proposed that related endonucleases recognizing a common sequence core gtctc possess two active sites for cleavage of both strands in the dna substrate. here, we present bioinformatic identification and experimental evidence for a single nuclease active site. we identified a short region of homology between eco31i and hnh nucl ... | 2007 | 17499273 |
| effect of neoadjuvant epirubicin and total androgen blockade on complete pathological response in patients with clinical stage t3/t4 prostate cancer. | most patients with stage t3-t4 prostate cancer experience disease relapse despite radiation and/or hormonal therapy, and their management remains controversial. we investigated the feasibility of, and the pathological response induced by neoadjuvant chemo-hormonal treatment in men with clinical stage t3/t4. | 2008 | 17502132 |
| [propositions of interpretative comments for thyroid function tests]. | in the field of thyroid disease, a number of governmental organisms or professional associations have published practice guidelines containing laboratory-related recommendations, eg the haute autorité de la santé (has), or the american thyroid association (ata). among the physicians who prescribe thyroid function tests, all have not read and memorized all these recommendations. in order to help them to better integrate these recommendations in their practice, we have composed a thesaurus of read ... | 2007 | 17502308 |
| favorable clinical heart and bone effects of anti-thyroid drug therapy in endogenous subclinical hyperthyroidism. | although subclinical hyperthyroidism (sch) has been associated with increased risk of osteoporosis and cardiac arrhythmias, its treatment is still controversial. this study was designed as a prospective, randomized, intervention, control-study with a 1-year follow-up in order to investigate whether normalization of serum tsh in sch using methimazole has favorable bone and heart clinical effects. fourteen patients with endogenous sch (not graves' disease) were enrolled, 7 (5 women/2 men; group t) ... | 2007 | 17505157 |
| reciprocal relation of thyroid-stimulating hormone and thyroid-stimulating immunoglobulin in a patient with endogenous subclinical hyperthyroidism. | a 72-year-old white woman with an abnormal serum thyroid-stimulating hormone (tsh) concentration was referred to our facility for a comprehensive evaluation. circulating thyroxine (t4) and free thyroxine (ft4) concentrations were all in the normal range. tri-iodothyronine (t3) concentrations were in the low end or slightly below the normal range. tsh was detectable but was below the limits of the normal range. the patient was clinically euthyroid and was receiving medication only for treatment o ... | 2007 | 17505173 |
| f-18 fluorodeoxy-d-glucose positron emission tomography scan in the initial evaluation of patients with a primary melanoma thicker than 4 mm. | metabolic imaging with f-18 fluorodeoxy-d-glucose positron emission tomography is one of the most sensitive and non-invasive techniques, and has proved useful in melanoma. we designed, in 2004, at the institute gustave roussy, a prospective study to determine the value of f-18 fluorodeoxy-d-glucose positron emission tomography scanning in the detection of regional and/or distant metastasis in 25 new patients referred for the treatment of a primary melanoma thicker than 4 mm (tumor node metastase ... | 2007 | 17505260 |
| prosthetic replacement and tangential resection of the superior vena cava in chest tumors. | infiltration of the superior vena cava (svc) due to advanced non small cell lung cancer (nsclc) or thymoma can be treated by prosthetic replacement or tangential resection. these two technical procedures and their results are described. | 2007 | 17505442 |
| iiib-t4 non-small cell lung cancer: indications and results of surgical treatment. | t4 non-small cell lung cancer (nsclc) is commonly considered a contraindication to surgery, indeed chemo-radiotherapy achieves a poor survival rate. we have reviewed our experience with t4 nsclc patients who underwent surgery with the aim of debating the indications and results of surgical treatment in this highly selected group of patients. | 2007 | 17505443 |
| haemodynamic changes and heart rate variability during midazolam-propofol co-induction. | in a prospective, blind, randomised study, we examined the effects of midazolam-propofol co-induction on haemodynamic (blood pressure, heart rate and stroke volume) and heart rate variability. the latter was measured by spectral analysis using the maximum-entropy method to calculate the following: the low frequency component (lf), which reflects both the cardiac sympathetic and parasympathetic activity, the high frequency component (hf) and entropy, which reflects the cardiac parasympathetic act ... | 2007 | 17506733 |
| [symptomatic intramedullary arachnoid cyst. report of two cases and literature review]. | the objective of this work is to present and discuss the rare situation of curable medullary compression with favorable prognosis. | 2007 | 17507047 |
| retroperitoneal lymph node dissection (rpld) in conjunction with nephroureterectomy in the treatment of infiltrative transitional cell carcinoma (tcc) of the upper urinary tract: impact on survival. | to evaluate the prognostic impact of retroperitoneal lymph node dissection (rpld) performed during nephroureterectomy on time to recurrence and survival in patients with infiltrative transitional cell carcinoma (tcc) of the upper urinary tract. | 2007 | 17507148 |
| a randomized, open-label, crossover study comparing the effects of oral versus transdermal estrogen therapy on serum androgens, thyroid hormones, and adrenal hormones in naturally menopausal women. | to compare the changes induced by oral versus transdermal estrogen therapy on the total and free serum concentrations of testosterone (t), thyroxine (t4), and cortisol (c) and the concentrations of their serum binding globulins sex hormone-binding globulin, thyroxine-binding globulin, and cortisol-binding globulin in naturally menopausal women. | 2007 | 17507833 |
| a curative resection improves the postoperative survival rate even in patients with advanced gallbladder carcinoma. | the aim of this study was to evaluate the results of our series of 90 operations for gallbladder carcinoma according to the japanese society of biliary surgery (jsbs) classification system and to clarify the appropriate surgical strategy for advanced gallbladder carcinoma based on the depth of primary tumor invasion and lymph node metastasis. generally, only a surgical resection can achieve a prognostic improvement of the advanced gallbladder carcinoma. the survival of patients with this neoplas ... | 2007 | 17508256 |
| rap1 integrates tissue polarity, lumen formation, and tumorigenic potential in human breast epithelial cells. | maintenance of apico-basal polarity in normal breast epithelial acini requires a balance between cell proliferation, cell death, and proper cell-cell and cell-extracellular matrix signaling. aberrations in any of these processes can disrupt tissue architecture and initiate tumor formation. here, we show that the small gtpase rap1 is a crucial element in organizing acinar structure and inducing lumen formation. rap1 activity in malignant hmt-3522 t4-2 cells is appreciably higher than in s1 cells, ... | 2007 | 17510404 |
| sphincter-preserving r0 total mesorectal excision with resection of internal genitalia combined with pre- or postoperative chemoradiation for t4 rectal cancer in females. | to evaluate the impact of chemoradiation admi-nistered pre- or postoperatively on prognosis in females following r0 extended resection with sphincter-preserving total mesorectal excision (tme) for locally advanced rectal cancer and to assess the association between chemoradiation and intra- and postoperative variables. | 2007 | 17511034 |
| elevated circulating level of osteopontin is associated with advanced disease state of non-small cell lung cancer. | osteopontin (opn) plays important roles in tumor progression and metastasis through binding to opn receptors such as alpha(v)beta(beta) integrin and cd44, and its overexpression in tumor is associated poor clinical outcome of nsclc patients. circulating opn levels, measured by elisa in 130 nsclc cases that had not been treated for cancer at the time of sampling, were analyzed according to clinical, pathologic parameters and single nucleotide polymorphisms (snps) in the opn gene promoter. advance ... | 2007 | 17513004 |
| correlation between size of renal cell carcinoma and its grade, stage, and histological subtype. | the aim of this study was to determine the correlation between histological subtype, size, grade, and stage of the kidney tumors and to investigate whether a correlation exists between the size of the kidney tumor and its behavior. | 2007 | 17514604 |
| [two cases of hyperthyroidism induced by interferon-alpha therapy for renal cell carcinoma]. | autoimmune thyroid disease is the result of a common side-effect of interferon-alpha (ifn-alpha) used to treat viral hepatitis c; but there have been few reports on thyroid disorders induced by ifn-a that was used to treat renal cell carcinoma. ifn-alpha therapy was conducted on two male patients, 75 and 44 years old, after radical nephrectomy. six and five months, respectively, after this therapy, they complained of weight loss. laboratory evaluation revealed hyperthyroidism; the thyroid stimul ... | 2007 | 17515071 |
| the position of the aorta relative to the spine in patients with left thoracic scoliosis: a comparison with normal patients. | analysis axial magnetic resonance images (mris) identifying the position of the aorta in left thoracic scoliosis and normal patients. | 2007 | 17515808 |
| the position of the aorta relative to the spine: is it mobile or not? | this study analyzes the mobility of the aorta relative to the spine in patients with a herniated thoracic disc requiring surgical intervention. | 2007 | 17515812 |
| rna chaperone activity of l1 ribosomal proteins: phylogenetic conservation and splicing inhibition. | rna chaperone activity is defined as the ability of proteins to either prevent rna from misfolding or to open up misfolded rna conformations. one-third of all large ribosomal subunit proteins from e. coli display this activity, with l1 exhibiting one of the highest activities. here, we demonstrate via the use of in vitro trans- and cis-splicing assays that the rna chaperone activity of l1 is conserved in all three domains of life. however, thermophilic archaeal l1 proteins do not display rna cha ... | 2007 | 17517772 |
| a facile method for attaching nitroxide spin labels at the 5' terminus of nucleic acids. | in site-directed spin labeling (sdsl), a nitroxide moiety containing a stable, unpaired electron is covalently attached to a specific site within a macromolecule, and structural and dynamic information at the labeling site is obtained via electron paramagnetic resonance (epr) spectroscopy. successful sdsl requires efficient site-specific incorporation of nitroxides. work reported here presents a new method for facile nitroxide labeling at the 5' terminus of nucleic acids of arbitrary sizes. t4-p ... | 2007 | 17517787 |
| a three-dimensional evaluation of postoperative swelling following orthognathic surgery at 6 months. | advances in three-dimensional technology have enabled applications for the clinical setting to be created and used in routine diagnosis, treatment planning, and patient education. the objectives of this prospective clinical trial were to determine the volume changes associated with facial swelling following orthognathic surgery. | 2007 | 17519721 |
| [in situ hybridization study on the expression of kiss-1 and kai-1 metastasis suppressor genes in gastric cancer]. | to investigate the mrna levels of kiss-1 and kai-1 metastasis suppressor genes in gastric cancer, and to explore its clinical value. | 2007 | 17520389 |
| s-100b release during carotid endarterectomy under local anesthesia. | the neuronal protein s-100b has been found to be an indicator of cellular brain damage. the aim of the study was to evaluate whether cross-clamping of the carotid artery for carotid endarterectomy (cea) under local anesthesia is associated with the same s-100b release pattern as during general anesthesia, where an increase in s-100b concentration in the jugular vein blood of 120% has been reported. in 45 consecutive patients undergoing cea under local anesthesia, serum s-100b samples were drawn ... | 2007 | 17521874 |
| staging of hepatocellular carcinoma: assessment of the japanese tnm and ajcc/uicc tnm systems in a cohort of 13,772 patients in japan. | the aims of this study were to present evidence to develop and validate the japanese tumor-node-metastasis (tnm) staging system for primary liver cancer and to compare its discriminatory ability and predictive power with those of vauthey's simplified staging, which was adopted as the tnm staging system of the american joint committee on cancer (ajcc)/international union against cancer (uicc). | 2007 | 17522517 |
| stability following combined orthodontic-surgical treatment for skeletal anterior open bite - a cephalometric 15-year follow-up study. | the aim of the present study was to evaluate the long-term skeletal and dento-alveolar stability 15 years after combined orthodontic and surgical correction of skeletal anterior open bite. | 2007 | 17522808 |
| metastasis in para-aortic lymph nodes in patients with advanced gastric cancer, treated with extended lymphadenectomy. | lymph node dissection is an essential component of curative resection for advanced gastric cancer. to improve the survival of n2 patients, asian surgeons have been performing d2+para-aortic lymph node dissection. the current study presents the results of lymph node status from multicenter trial of d2 and d2 + para-aortic nodal (no.16) dissection (d4 dissection). | 2007 | 17523339 |
| [effect of losartan on the state of kidney function in rats with experimental hyperthyroidism]. | the effect of losartan on the functional state of kidneys was studied in white rats with the experimental hyperthyroidism caused by a 5-day oral administration exogenous t4 thyroxine in a dose of 50 microg/(100 g body weight). then, the test rats were divided into two groups and animals in the first group received water, while animals in the second group were treated with a losartan solution (10 mg/1) during 24 hours. then, the function of kidneys was studied under the condition of 5% water load ... | 2007 | 17523456 |
| triplet excited fluoroquinolones as mediators for thymine cyclobutane dimer formation in dna. | a series of fluoroquinolones (fqs), including enoxacin (enx), pefloxacin (pfx), norfloxacin (nfx), its n(4')-acetyl derivative (anfx), ofloxacin (ofx), and rufloxacin (rfx) have been investigated to determine their potential as dna photosensitizers via thymine cyclobutane dimer (t<>t) formation in dna. at fluoroquinolone concentrations and light doses insufficient to produce direct single strand breaks, enx, pfx, and nfx were able to produce t<>t dimers in dna, revealed by enzymatic treatment wi ... | 2007 | 17523621 |
| altered cardiovascular vagal responses in nonelderly female patients with subclinical hyperthyroidism and no apparent cardiovascular disease. | subclinical hyperthyroidism (sh) has been associated with exercise intolerance, changes in cardiac morphology, atrial arrhythmias and sympathovagal imbalance. the aim of this study was to evaluate the vagal reserve and modulation by a sympathetic stimulus in nonelderly patients with sh without cardiovascular problems. | 2007 | 17524031 |
| the rationale for radical cystectomy as primary therapy for t4 bladder cancer. | treatment of t4 bladder cancer patients remains a clinical challenge. conservative management is often insufficient regarding local control, neoadjuvant chemotherapy delays definite treatment while leading to increased therapy-associated morbidity and mortality during the course of the disease. primary cystectomy has also been reported to be associated with a high complication rate and unsatisfactory clinical efficacy. herein, we report postoperative outcome, including therapy-related complicati ... | 2007 | 17525849 |
| inactivation of e. coli, b. subtilis spores, and ms2, t4, and t7 phage using uv/h2o2 advanced oxidation. | the goal of this study was to evaluate the potential of an advanced oxidation process (aop) for microbiocidal and virucidal inactivation. the viruses chosen for this study were bacteriophage ms2, t4, and t7. in addition, bacillus subtilis spores and escherichia coli were studied. by using h(2)o(2) in the presence of filtered ultraviolet (uv) irradiation (uv/h(2)o(2)) to generate wavelengths above 295nm, the direct uv photolysis disinfection mechanism was minimized, while disinfection by h(2)o(2) ... | 2007 | 17532124 |
| evidence-based radiation oncology: definitive, adjuvant and salvage radiotherapy for non-metastatic prostate cancer. | the standard treatment options based on the risk category (stage, gleason score, psa) for localized prostate cancer include surgery, radiotherapy and watchful waiting. the literature does not provide clear-cut evidence for the superiority of surgery over radiotherapy, whereas both approaches differ in their side effects. the definitive external beam irradiation is frequently employed in stage t1b-t1c, t2 and t3 tumors. there is a pretty strong evidence that intermediate- and high-risk patients b ... | 2007 | 17532494 |
| influence of dietary fats on ecstasy-induced hyperthermia. | studies were designed to examine the effects of dietary fats on metabolic effects of 3,4-methylenedioxymethamphetamine (mdma, ecstasy). these effects included hyperthermia, expression of uncoupling protein (ucp1 and 3) in brown adipose tissue or skeletal muscle and plasma free fatty acid (ffa) levels. | 2007 | 17533413 |
| [description of the medical care of younger patients (<65 years) with colorectal cancer in schleswig-holstein--are diagnostics and therapy compliant with the actual s3-guidelines?]. | the guideline colorectal cancer has been existed since 1999. in 2004, a revision was published in form of the s3-guideline (number of the awmf registry: 021/007). in this study we aimed to evaluate whether diagnostics and therapy of colorectal cancer of younger patients (<65 years) in schleswig-holstein (sh) were in accordance with the guideline or not. therefore patients from a molecular genetic research project ("popgen") were asked to complete a questionnaire regarding their medical care. dat ... | 2007 | 17533563 |
| [long-term follow-up of oral language development in children with permanent bilateral hearing loss]. | the aim of this study was to assess the oral language development of children with permanent bilateral hearing loss without additional disabilities longitudinally (5 time points t1-t5). | 2007 | 17533568 |
| differential t4 degradation pathways in young patients with preterminal and terminal renal failure. | the aim of this study is to analyze thyroid hormone parameters in large homogenous patient cohorts with preterminal (stage 4) and terminal (stage 5) renal failure in an area of low iodine intake. | 2007 | 17533577 |
| thyroid hormone resistance without mutations in thyroid hormone receptor beta. | resistance to thyroid hormone (rth) is a rare autosomal dominant disorder that leads to elevated free thyroid hormone levels in the presence of normal or increased serum thyroid-stimulating hormone (tsh) concentrations if it is generalized because both the pituitary and peripheral tissues are then partially resistant. in approximately 85% of patients with rth, mutations in the thyroid hormone receptor beta (tr beta) gene can be identified. | 2007 | 17534237 |
| tsh concentration within the normal range is associated with cognitive function and adhd symptoms in healthy preschoolers. | thyroid hormone concentrations outside the normal range affect brain development, but their specific influence on behaviour and mental abilities within normal values is unknown. the objective of this study was to investigate whether thyroid hormone concentrations are related to neurodevelopment and adhd (attention deficit and hyperactivity disorder) symptoms in healthy preschoolers. design subjects and measurements: children from two general population birth cohorts in menorca (n = 289) and ribe ... | 2007 | 17535399 |
| melatonin and thyroxine response to pollution in white stork nestlings (ciconia ciconia): aspects of rhythmicity and age. | there is growing evidence that ubiquitous environmental contaminants may interfere with vertebrate endocrine systems. the selected endocrine biomarkers are used to indicate the condition of free-ranging populations of wildlife, including avian species. the aim of this study was to determine the impact of environment quality on serum thyroxine (t4) and melatonin (mel) in white stork nestlings (ciconia ciconia) living in different locations: small villages in natural areas surrounded by forests an ... | 2007 | 17535774 |
| cardiac angiotensin ii type i and type ii receptors are increased in rats submitted to experimental hypothyroidism. | this study assessed the behaviour of angiotensin ii (ang ii) receptors in an experimental hypothyroidism model in male wistar rats. animals were subjected to thyroidectomy and resting for 14 days. the alteration of cardiac mass was evaluated by total heart weight (hw), right ventricle weight (rvw), left ventricle weight (lvw), ratio of hw, rvw and lvw to body weight (bw) and atrial natriuretic factor (anf) expression. cardiac and plasma ang ii levels and serum t3 and t4 were determined. the mrna ... | 2007 | 17540701 |
| lymphoepithelioma-like carcinoma of the urinary tract: a clinicopathological study of 30 pure and mixed cases. | we studied 28 cases of lymphoepithelioma-like carcinoma of the bladder, one case in the renal pelvis, and one in the urethra. the mean age of the patients was 67.6 years with 21 (70%) males. seventeen cases (56.7%) were pure with the remaining mixed with other patterns of carcinoma, including invasive urothelial carcinoma (n=10), invasive adenocarcinoma (n=3), and squamous cell carcinoma (n=2). the surface demonstrated carcinoma in situ (cis) in six cases, noninvasive high-grade papillary urothe ... | 2007 | 17541442 |
| micropapillary bladder cancer: a review of the university of texas m. d. anderson cancer center experience with 100 consecutive patients. | micropapillary bladder carcinoma is a rare variant of urothelial carcinoma. to improve understanding of this disease, the authors performed a retrospective review of their experience. | 2007 | 17542024 |
| psoriasiform lesions and abscesses as initial manifestations of severe hypothyroidism in a previously healthy 15-year-old girl. | hypothyroidism is associated with many characteristic cutaneous manifestations; however, to the best of our knowledge, it has not previously been linked to psoriasiform lesions or multiple abscesses. we describe a previously healthy 15-year-old girl with psoriasiform lesions, abscesses, and extremely severe hypothyroidism, all presenting simultaneously. the pathophysiology of the connection is unclear, but several hypotheses are discussed. the temporal relationship of these conditions and the si ... | 2007 | 17542892 |
| thyroid hormones, learning and memory. | thyroid hormones (ths), t3 and t4, have many physiological actions and are essential for normal behavioral, intellectual and neurological development. ths have a broad spectrum of effects on the developing brain and mediate important effects within the cns throughout life. insufficient maternal iodine intake during gestation and th deficiency during human development are associated to pathological alterations such as cretinism and mental retardation. in adulthood, thyroid dysfunction is related ... | 2007 | 17543038 |
| assembly of the small outer capsid protein, soc, on bacteriophage t4: a novel system for high density display of multiple large anthrax toxins and foreign proteins on phage capsid. | bacteriophage t4 capsid is a prolate icosahedron composed of the major capsid protein gp23*, the vertex protein gp24*, and the portal protein gp20. assembled on its surface are 810 molecules of the non-essential small outer capsid protein, soc (10 kda), and 155 molecules of the highly antigenic outer capsid protein, hoc (39 kda). in this study soc, a "triplex" protein that stabilizes t4 capsid, is targeted for molecular engineering of t4 particle surface. using a defined in vitro assembly system ... | 2007 | 17544446 |
| local progression among men with conservatively treated localized prostate cancer: results from the transatlantic prostate group. | men with clinically detected localized prostate cancer treated without curative intent are at risk of complications from local tumor growth. we investigated rates of local progression and need for local therapy among such men. | 2008 | 17544572 |
| salvage surgery with free flap reconstruction: factors affecting outcome after treatment of recurrent head and neck squamous carcinoma. | to determine factors predicting the outcome after salvage surgery with microvascular flap reconstruction for recurrent squamous cell cancer (scc) of the head and neck. | 2007 | 17545864 |
| [evidences for subclinic chronic autoimmune thyroid disease in girls with turner syndrome]. | patients with turner syndrome (ts) frequently exhibit transient, recurrent and asymptomatic variations of tsh and/or thyroid hormones (th). this work was carried out to evaluate thyroid function and structure in patients with ts who had had such variations in hormone concentrations. our sample comprised 24 patients, 17 less than 20-years old. evaluation included serum levels of tsh, free t4, total t3, tpo and tg autoantibodies, thyroid ultrasound (us) and scintigraphy with 99mtc-pertechnetate. t ... | 2007 | 17546238 |
| transoral laser microsurgery for carcinoma of the supraglottic larynx. | the study goal was to report the oncologic outcomes of transoral laser microsurgery (tlm) in the treatment of squamous cell carcinoma of the supraglottic larynx. | 2007 | 17547977 |
| combined therapy after superselective arterial cisplatin infusion to treat maxillary squamous cell carcinoma. | we sought to assess the efficacy of combined therapy after superselective arterial cisplatin infusion (saci) therapy to treat the maxillary squamous cell carcinoma. | 2007 | 17547996 |
| evaluation of nad(+) -dependent dna ligase of mycobacteria as a potential target for antibiotics. | mycobacteria contain genes for several dna ligases, including liga, which encodes a nad(+)-dependent enzyme that has been postulated to be a target for novel antibacterial compounds. using a homologous recombination system, direct evidence is presented that wild-type liga cannot be deleted from the chromosome of mycobacterium smegmatis. deletions of native liga in m. smegmatis could be obtained only after the integration of an extra copy of m. smegmatis or mycobacterium tuberculosis liga into th ... | 2007 | 17548501 |
| administration of additional inactive iodide during radioiodine therapy for graves' disease: who might benefit? | graves' hyperthyroidism and antithyroid drugs empty the intrathyroid stores of hormones and iodine. the consequence is rapid 131i turnover and impending failure of radioiodine therapy. can administration of additional inactive iodide improve 131i kinetics? | 2007 | 17549318 |
| the role of the endothelin axis and microvessel density in bladder cancer - correlation with tumor angiogenesis and clinical prognosis. | endothelin-1 (et-1) and its receptors, entothelin-a (etar) and endothelin-b (etbr), commonly referred to as the endothelin (et)-axis, are involved in tumor biology and growth. we investigated the effects of the et-axis on microvessel density (mvd) and the clinicopathological parameters of patients with invasive bladder cancer. paraffin tumor sections of 120 patients who had undergone radical cystectomy were assessed immunohistochemically using mono- and polyclonal antibodies for et-1, etar, etbr ... | 2007 | 17549358 |
| surgical management and outcome in primary adenocarcinoma of the small bowel. | primary adenocarcinoma of the small bowel is a rare malignancy and is associated with poor survival outcome. patient, tumor and treatment-related factors were analyzed for their association with recurrence and survival. | 2007 | 17549572 |
| phase ii study of preoperative irradiation and chemotherapy with capecitabine in patients with locally advanced rectal carcinoma. | preoperative chemoradiotherapy has demonstrated to improve resectability and local control in locally advanced rectal cancer (larc). 5-fluorouracil (5fu) has traditionally been the drug of choice in combination with radiation therapy. early studies of capecitabine (cap) have shown its potential to replace 5fu. between march 2002 and april 2005, 31 patients with newly diagnosed larc (t2 n+ 2 cases, t3 n0-n+ 25 cases, t4 n0-n+ 4 cases) received the combined treatment. surgery was planned 6-8 weeks ... | 2007 | 17550133 |
| is final tnm staging a predictor for survival in locally advanced rectal cancer after preoperative chemoradiation therapy? | neoadjuvant chemoradiation therapy has improved the local control rate and overall survival in locally advanced rectal cancers. the purpose of this retrospective study is to evaluate the correlation between the final pathologic stage and survival in these patients. | 2007 | 17551794 |
| [the assessment of body composition using dexa in patients with thyroid dysfunction]. | disturbed thyroid function is accompanied with weight changes in most of patients. less is known how the therapy of hyperthyroidism and hypothyroidism influences their body composition. | 2007 | 17554975 |
| [effects of iodine excess and selenium supplement on the levels of thyroid hormone and its receptor expression in filial cerebrum of mice]. | to study effects of iodine excess on the levels of serum t4 and t3 and tralpha1 and trbeta1 expression in the cerebrum of filial mice and the supplement of selenium. | 2007 | 17555094 |
| the association of time of day and serum testosterone concentration in a large screening population. | to assess testosterone patterns during clinical hours in a large population of men participating in a national screening programme for prostate cancer, as the effect of time of day on serum testosterone concentration is unclear and largely reported in small studies. | 2007 | 17555474 |
| clinical relevance of highly sensitive tg assay in monitoring patients treated for differentiated thyroid cancer. | serum thyroglobulin (tg) represents a highly specific biomarker for detecting residual thyroid tissue/recurrence/metastases after treatment for differentiated thyroid cancer (dtc). we evaluated the clinical impact of a highly sensitive tg assay during routine follow-up of dtc patients. | 2007 | 17555505 |
| neurosensory and functional impairment in sagittal split osteotomies: a longitudinal and long-term follow-up study. | the aim was to conduct a long-term follow-up study on the function and sensitivity of the mandible in advancement and setback patients after bilateral sagittal split osteotomy (bsso) with rigid internal fixation. the advancement and setback groups consisted of 16 (12 females and 4 males, mean age: 21.4 and 21.3 years, respectively) and 17 (11 females and 6 males, mean age: 27.1 and 27.7 years, respectively). the final follow-up was a mean of 12.7 years (t4) post-operatively. the other follow-up ... | 2007 | 17556728 |
| proposal of a diagnostic test for the detection of preterm premature rupture of membranes based on the determination of thyroid hormones in vaginal washing fluid. | to determine whether measurement of total t3 (triiodothyronine) , total t4 (thyroxine), free t3 (free triiodothyronine) and free t4 (free thyroxine) levels in vaginal fluid is useful for the diagnosis of preterm premature rupture of membranes (pprom). | 2007 | 17556818 |
| ultrasonography thyroid volume estimation in hyperthyroid patients treated with individual radioiodine dose. | radioiodine (rai) therapy is a safe and effective treatment for hyperthyroidism and individual doses are frequently administered. initial thyroid volume (tv) is an important parameter for rai therapy. ultrasonography (us) is considered the most reliable method of determining tv. the aim of this study was to evaluate tv by means of us in a cohort of 75 hyperthyroid patients before and after rai therapy. according to clinical examination, thyroid us and technetium-99m (99mtc)-pernechnetate scintis ... | 2007 | 17556869 |
| viral dna packaging studied by fluorescence correlation spectroscopy. | the dna packaging machinery of bacteriophage t4 was studied in vitro using fluorescence correlation spectroscopy. the atp-dependent translocation kinetics of labeled dna from the bulk solution, to the phage interior, was measured by monitoring the accompanied decrease in dna diffusibility. it was found that multiple short dna fragments (100 basepairs) can be sequentially packaged by an individual phage prohead. fluorescence resonance energy transfer between green fluorescent protein donors withi ... | 2007 | 17557791 |
| microsatellite instability in poorly differentiated adenocarcinomas of the colon and rectum: relationship to clinicopathological features. | poorly differentiated adenocarcinomas of the colon and rectum (por) feature the worst prognosis among the various types of colorectal carcinomas. por is highly associated with microsatellite instability (msi), although msi is associated with an improved prognosis in colorectal cancers. | 2007 | 17557871 |
| inverse relationship between vertebral fractures and spine osteoarthritis in postmenopausal women with osteoporosis. | although the coexistence of osteoarthritis and osteoporosis is considered as uncommon, it has been suggested that, in postmenopausal women, disc space narrowing increases the risk of vertebral fracture. the aim of this study was to check this hypothesis in postmenopausal women with osteoporosis. | 2008 | 17557888 |
| preoperative undetectable serum thyroglobulin in differentiated thyroid carcinoma: incidence, causes and management strategy. | in recent years serum thyroglobulin (tg) measurement during thyroxine (t4) treatment and/or after stimulation by endogenous tsh or recombinant human tsh (rhtsh) has eclipsed other diagnostic procedures in managing patients with differentiated thyroid cancer (dtc). however, preoperative undetectable tg was reported in up to 12% of patients affected by dtc and recurrences of dtc with no increase in serum tg have also been described. clearly, a negative tg measurement may falsely reassure both the ... | 2007 | 17561976 |
| [cloning and identification of microrna from human osteosarcoma cell line sosp-9607]. | microrna (mirna), a group of non-coding small rna (20-25 nt) involved in post-transcriptional regulation, regulate gene expression and closely relate to cancer pathogenesis. this study was to clone mirna from osteosarcoma cell line sosp-9607, and identify the expression of some functional genes. | 2007 | 17562257 |
| the impact of health insurance status on stage at diagnosis of oropharyngeal cancer. | although patients who have early-stage oropharyngeal cancer can be treated with little impairment of function, the treatment of advanced disease can result in decreased quality of life and mortality. patients without insurance and with other barriers to access to care may delay seeking medical attention for early symptoms, resulting in more advanced disease at presentation. in this study, the authors examined whether patients who had no insurance or who were covered by medicaid insurance were mo ... | 2007 | 17562558 |
| [clinical study of adenoid cystic carcinoma of the parotid gland]. | we report results of a retrospective study of 12 cases of adenoid cystic carcinoma (acc) in the parotid gland. local pain was often observed in acc among other malignant parotid tumors. although fine-needle aspiration cytology (fna) was not effective for preoperative diagnosis, frozen section diagnosis (fs) during surgery showed excellent results. cases with t3 or t4 underwent total or enlarged parotidectomy, but, often showed positive surgical margins. postoperative radiation therapy seemed use ... | 2007 | 17564131 |
| the usefulness of transesophageal echocardiography in the staging of locally advanced lung cancer. | the pre-operative staging of locally advanced non-small cell lung cancer (nsclc) is an important clinical and radiological issue. computed tomography (ct) scan cannot always provide sufficient information about resectability and some patients may undergo unnecessary thoracotomy. the purpose of this study was to evaluate the utility of transesophageal echocardiography (tee) in distinguishing t3 from t4 lesions in patients with lung cancer possibly involving cardiovascular structures and to compar ... | 2007 | 17564283 |
| genomic and structural analysis of syn9, a cyanophage infecting marine prochlorococcus and synechococcus. | cyanobacteriophage syn9 is a large, contractile-tailed bacteriophage infecting the widespread, numerically dominant marine cyanobacteria of the genera prochlorococcus and synechococcus. its 177,300 bp genome sequence encodes 226 putative proteins and six trnas. experimental and computational analyses identified genes likely involved in virion formation, nucleotide synthesis, and dna replication and repair. syn9 shows significant mosaicism when compared with related cyanophages s-pm2, p-ssm2 and ... | 2007 | 17564603 |
| sevoflurane increases fade of neuromuscular response to tof stimulation following rocuronium administration in children. a pk/pd analysis. | sevoflurane enhances neuromuscular block produced by rocuronium, affecting not only single twitch response but also the response to high-frequency stimulation, increasing tetanic [or train-of-four (tof)] fade. | 2007 | 17564645 |
| [surgical strategy for stage iii non-small cell lung cancer; a review based on our experience and the literature]. | we reviewed our experience and the literature to clarify the resection indication and pre-/postoperative treatment for stage iii non-small cell lung cancer. surgery alone should not be applied to patients with stage iiia non-small cell lung cancer except for clinical t3n1m0 cases. an indication of pulmonary resection for clinical t1-3n2m0 cases should be added to preoperative induction therapy, such as chemo-or chemoradiation therapy. postoperative n2 cases, which were diagnosed as n0-1 disease ... | 2007 | 17565243 |
| evaluation of plantar hyperhidrosis in patients undergoing video-assisted thoracoscopic sympathectomy. | sympathectomy is the treatment of choice for primary hyperhidrosis. one curious occurrence that is difficult to explain from an anatomophysiological point of view in cases of video-assisted thoracoscopic sympathectomy (vats) for the treatment of palmar hyperhidrosis (ph) is the observed improvement in plantar hyperhidrosis (plh). nevertheless, current reports on vats rarely describe the effect on plh or just give superficial data. the aim of this study was to prospectively investigate, how surge ... | 2007 | 17565429 |
| activation of glycogen synthase kinase 3beta promotes the intermolecular association of tau. the use of fluorescence resonance energy transfer microscopy. | tau is hyperphosphorylated and undergoes proteolysis in alzheimer disease brain. caspase-cleaved tau efficiently forms fibrillary structures in vitro and in situ. glycogen synthase kinase 3beta (gsk3beta) phosphorylates tau and induces the aggregation of caspase-cleaved tau in situ. given the hypothesis that increased association of tau precedes the formation of fibrillar structures, we generated a cell model to quantitate the extent of tau association in situ using fluorescence resonance energy ... | 2007 | 17565981 |
| the feasibility of using delta15n and delta13c values for discriminating between conventionally and organically fertilized pepper (capsicum annuum l.). | a greenhouse experiment was conducted to determine the feasibility of using leaf and fruit delta15n and delta13c values to discriminate between conventionally and organically fertilized peppers, when conventional management involves the application of organic amendment for soil preparation. all of the treatments involved adding horse manure to the soil before applying different rates of synthetic n fertilizers: 0 (t1 and t2), 150 (t3), and 300 kg ha(-1) (t4). the difference between t1 and t2 was ... | 2007 | 17567025 |
| extending low-dose epidural analgesia in labour for emergency caesarean section - a comparison of levobupivacaine with or without fentanyl. | women in labour receiving epidural analgesia with 15 ml bupivacaine 0.1% and 2 microg.ml(-1) fentanyl followed by 10-15-ml top-ups as required, who needed caesarean section, were randomly allocated to receive 20 ml levobupivacaine 0.5% over 3 min with either 75 microg fentanyl (1.5 ml) or 1.5 ml saline. further top-ups or inhaled or intravenous supplementation were given for breakthrough pain. time to onset (loss of cold sensation to t4 and touch sensation to t5 bilaterally), quality of analgesi ... | 2007 | 17567341 |
| thyroid hormone replacement normalizes renal renin and angiotensin receptor expression in thyroidectomized fetal sheep. | previous studies have suggested that thyroid hormone influences maturation of the renin-angiotensin system (ras) and cardiovascular function in the late-gestation fetal sheep. to further examine the importance of thyroid hormone in this regard, we used the technique of thyroidectomy (tx) to remove endogenous thyroid hormone from the circulation and then replaced it with physiological amounts of exogenous thyroxine. we hypothesized that the previously observed changes in ras activity and cardiova ... | 2007 | 17567715 |