| selective mastectomy in the management of locally advanced breast cancer. | to evaluate local control for patients with locally advanced noninflammatory breast cancer (labc) managed by selective mastectomy. | 2007 | 17398030 |
| exploring subdomain cooperativity in t4 lysozyme ii: uncovering the c-terminal subdomain as a hidden intermediate in the kinetic folding pathway. | intermediates along a protein's folding pathway can play an important role in its biology. previous kinetics studies have revealed an early folding intermediate for t4 lysozyme, a small, well-characterized protein composed of an n-terminal and a c-terminal subdomain. pulse-labeling hydrogen exchange studies suggest that residues from both subdomains contribute to the structure of this intermediate. on the other hand, equilibrium native state hydrogen experiments have revealed a high-energy, part ... | 2007 | 17400925 |
| exploring subdomain cooperativity in t4 lysozyme i: structural and energetic studies of a circular permutant and protein fragment. | small proteins are generally observed to fold in an apparent two-state manner. recently, however, more sensitive techniques have demonstrated that even seemingly single-domain proteins are actually made up of smaller subdomains. t4 lysozyme is one such protein. we explored the relative autonomy of its two individual subdomains and their contribution to the overall stability of t4 lysozyme by examining a circular permutation (cp13*) that relocates the n-terminal a-helix, creating subdomains that ... | 2007 | 17400926 |
| influence of injection rate of hyperbaric bupivacaine on spinal block in parturients: a randomized trial. | a prospective, randomized, double-blind clinical trial was undertaken to determine whether a tenfold difference in the rate of intrathecal injection of bupivacaine would affect sensory block level in parturients. secondary outcomes included onset of block and the incidence of hypotension and nausea. | 2007 | 17400981 |
| thyroid hormone responses to endurance exercise. | limited information exists about changes in circulating thyroid hormone concentrations during prolonged endurance exercise in horses. | 2006 | 17402388 |
| weekly docetaxel with concomitant radiotherapy in patients with inoperable oesophageal cancer. | to evaluate the efficacy and tolerability of weekly docetaxel concurrent with radiotherapy in inoperable oesophageal cancer patients. | 2007 | 17403629 |
| preoperative radio-chemotherapy (rt-ct) in rectal cancer. prospective study with postoperative rt-ct control group. | between 1996 and 2000, the colorectal tumour committee of the hospital universitario de bellvitge and the institut català d'oncologia, hospitalet, carried out a non-randomised prospective study of pre-op radio-chemotherapy (rt-ct) in locally advanced rectal tumours. we herein present the results. on the other hand, and at the same time, patients operated on for locally advanced rectal cancer were admitted and treated by rt-ct during the postoperative process, according to our standard protocol. ... | 2007 | 17403630 |
| interaction between cadmium, lead and potassium fertilizer (k2so4) in a soil-plant system. | a pot experiment was conducted to examine the influence of potassium (k) fertilizer (k(2)so(4)) application on the phytoavailability and speciation distribution of cadmium (cd) and lead (pb) in soil. spring wheat (triticum aestivum l.) was selected as the test plant. there were seven treatments including single and combined contamination of cd and pb. cdcl(2).2.5 h(2)o and pb(no(3))(2) were added to the soil at the following dosages: cd + pb = 0.00 + 0.00, 5.00 + 0.00, 25.0 + 0.00, 0.00 + 500, 0 ... | 2007 | 17404694 |
| coping strategies as determinants of quality of life in stroke patients: a longitudinal study. | quality of life (qol) is reduced for stroke patients and coping strategies have been suggested as determinants of qol. thus far the relationship between coping and qol has only been examined in small-scale cross-sectional designs. therefore, the current study set out to examine this relationship in a longitudinal setting. | 2007 | 17406109 |
| assaying rna chaperone activity in vivo in bacteria using a ribozyme folding trap. | here, we report an assay to evaluate the intracellular rna chaperone activity of a protein of interest in vivo in bacterial cells. the method is based on self-splicing of the group i intron, which is located in the thymidylate synthase (td) gene of phage t4. a previously described td mutant (tdsh1) has significantly impaired splicing due to formation of splicing-incompetent alternative structures. in this procedure, overexpression of rna chaperones in the presence of the td mutant sh1 is used to ... | 2006 | 17406411 |
| growth evaluation in infants with neonatal cholestasis. | [corrected] chronic liver diseases in childhood often cause undernutrition and growth failure. to our knowledge, growth parameters in infants with neonatal cholestasis are not available | 2006 | 17406760 |
| [five year survival of patients with primary oral squamous cell carcinoma. comparison of two treatment protocols in a prospective study]. | in recent years, different concepts for the treatment of oral squamous cell carcinomas (oscc) have been developed; these include preoperative simultaneous neoadjuvant radiochemotherapy and one-stage surgery with tumor ablation and reconstruction. when considering long-term survival, there is substantial evidence that multimodality treatment based on a neoadjuvant radiochemotherapy is superior to adjuvant therapy concepts based on a surgical approach with postoperative irradiation. the aim of thi ... | 2007 | 17406799 |
| thyroid function in children with sepsis and septic shock. | a prospective study was conducted to determine thyroid hormone levels and their relationship to survival in children with septic shock and sepsis. | 2007 | 17407466 |
| recognizing and reporting vertebral fractures: reducing the risk of future osteoporotic fractures. | given the increasing evidence that vertebral fractures are underdiagnosed and not acted on, osteoporosis canada and the canadian association of radiologists initiated a project to develop and publish a set of recommendations to promote and facilitate the diagnosis and reporting of vertebral fractures. | 2007 | 17408160 |
| prognosis of resected non-small cell lung cancer patients with intrapulmonary metastases. | in the current tnm staging system revised in 1997 for lung cancer, intrapulmonary metastases (pm) are classified into two categories: pm1 (in the same lobe of the primary tumor), designated as t4; and pm2 (in a different lobe), as m1. there have been no large-scale analyses on pm in non-small cell lung cancer (nsclc) patients. we collected data nationwide in japan for 7408 lung cancer patients undergoing surgical resection during a single year, 1994. we analyzed the long-term survival of nsclc p ... | 2007 | 17409798 |
| a phase ii study of concurrent carboplatin and paclitaxel and thoracic radiotherapy for completely resected stage ii and iiia non-small cell lung cancer. | to determine the feasibility of combining concurrent carboplatin/paclitaxel and thoracic radiotherapy (trt) for completely resected stage ii and iiia non-small cell lung cancer. | 2007 | 17409799 |
| mediastinoscopic ultrasonography. | pretherapeutic t4 staging of centrally located lung cancer is crucial for the treatment strategy, but non-invasive imaging techniques are of low accuracy. we have developed the new imaging technique of intraoperative mediastinoscopic ultrasound (mus) to predict technical resectability in tumors staged ct4 based on computed tomographic scanning. | 2007 | 17409812 |
| phase i study of paclitaxel given by seven-week continuous infusion concurrent with radiation therapy for locally advanced non-small cell lung cancer. | paclitaxel is active in non-small-cell lung cancer (nsclc) and is a radiosensitizer with a dose-response relationship that depends more on duration of exposure than peak concentration. a continuous infusion prolongs exposure and may maximize the drug-radiation interaction. the goal of this national cancer institute-sponsored phase i study was to determine the feasibility and toxicity of a continuous infusion paclitaxel (24 hours/day, 7 days/week, 7 weeks total) concurrent with standard radiation ... | 2006 | 17409825 |
| pet/ct fusion scan in lung cancer: current recommendations and innovations. | combined fluorodeoxyglucose-positron emission tomography (pet)/ computed tomography (ct) imaging has the potential to become the new standard imaging modality for the staging and restaging of patients with lung cancer. pet/ct is superior to pet alone, ct alone, and visual correlation of both techniques separately. in particular, it improves t3 and t4 staging and delineation of tumors associated with atelectasis. ct contrast media enhancement is probably only still needed when a substantial media ... | 2006 | 17409831 |
| the anatomical relationship between the aorta and the thoracic vertebral bodies and its importance in the placement of the screw in thoracoscopic correction of scoliosis. | thoracoscopically-assisted anterior spinal instrumentation is being used widely to treat adolescent idiopathic scoliosis (ais). recent studies have showed that screws placed thoracoscopically could counter the aorta or entrance into the spinal canal. there are a few studies defining the anatomic landmarks to identify the relationship between the aorta and the thoracic vertebral body using quantitative measurement for the sake of safe placement of thoracoscopic vertebral screw in anterior correct ... | 2007 | 17410383 |
| effects of polyethylene glycol and magnesium sulfate administration on clinically relevant neurological outcomes after spinal cord injury in the rat. | the purpose of this study was to determine the long-term effects of polyethylene glycol (peg) and magnesium sulfate (mgso(4)) on clinically relevant motor, sensory, and autonomic outcomes after spinal cord injury (sci). rats were injured by clip compression (50 g; t4) and treated 15 min and 6 hr postinjury intravenously (tail vein) with peg (1 g/kg, 30% w/w in saline; n = 11), mgso(4) (300 mg/kg; n = 5), peg + mgso(4) (n = 6), or saline (n = 10). behavioral testing lasted for 6 weeks, followed b ... | 2007 | 17410603 |
| [penis epidermoid tumors review]. | to study the characteristics and evolution of the epidermoid penis tumours. | 2007 | 17410979 |
| nmr evaluation of ammonium ion movement within a unimolecular g-quadruplex in solution. | d[g4(t4g4)3] has been folded into a unimolecular g-quadruplex in the presence of 15nh4+ ions. nmr spectroscopy confirmed that its topology is the same as the solution state structure determined earlier by wang and patel (j. mol. biol., 1995; 251: 76-94) in the presence of na+ ions. the d[g4(t4g4)3] g-quadruplex exhibits four g-quartets with three 15nh4+-ion-binding sites (o1, i and o2). quantitative analysis utilizing 15nh4+ ions as a nmr probe clearly demonstrates that there is no unidirectiona ... | 2007 | 17412708 |
| t3 and t4 true vocal cord squamous carcinomas treated with external beam irradiation: a single institution's 35-year experience. | the purpose of this study was to report the outcomes after external-beam radiotherapy (rt) for selected t3 and t4 vocal cord squamous cell carcinomas. | 2007 | 17414468 |
| neoadjuvant therapy and prostate cancer: what a urologist should know. | prostate cancer is curable only when treated at an early stage, when the tumor is still localized to the prostate gland. however, even in apparent cases of clinically localized disease, unsuspected extracapsular disease may significantly increase the risk of primary treatment failure. this risk is especially high if the patient has one or more of the following risk factors: a serum prostate-specific antigen level >20 ng/ml, a gleason score >7, locally advanced disease (clinical stage t3/t4), and ... | 2007 | 17414517 |
| effect of lower limb compression devices on thermodilution cardiac output measurement. | the aim of this study was to determine whether lower limb (calf) sequential compression devices (scds) have a significant effect on thermodilution cardiac output measurements using a pulmonary artery catheter. | 2007 | 17414727 |
| a biomechanical assessment of thoracic spine stapling. | an in vitro immature bovine study of thoracic spine fixation using shape memory alloy for minimally invasive adolescent scoliosis treatment. | 2007 | 17414910 |
| thoracic kyphotic deformity reduction with a distractible titanium cage via an entirely posterior approach. | surgical correction of thoracic kyphotic deformity is often associated with significant surgical and neurological morbidity and unsatisfactory reduction of kyphosis, especially in patients who cannot tolerate anterior thoracic procedures because of associated comorbidity. we describe a technique in which kyphotic deformity of the thoracic and thoracolumbar spine is corrected, decompressed, and stabilized with a circumferential fixation construct from a lone posterior approach. | 2007 | 17415157 |
| [establishment of an animal model for thyroid associated ophthalmopathy by treatment of mice with human thyrotropin receptors-activated splenocytes]. | objective: to establish an animal model for thyroid-associated ophthalmopathy (tao) by treatment of homoimmune balb/c mice with human thyrotropin receptors ( htshr )-activated splenocytes. methods twenty three balb/c mice were randomly divided into group a and b, which were immune with recombinant plasmid pcdna3. 1/htshr or blank plasmid pcdna3. 1 for 3 times at 3-week intervals, respectively. mice in these two groups were sacrificed 18 weeks after immunization and the splenocytes were isolated. ... | 2006 | 17415963 |
| [impact of extracapsular lymph node spread in the ipsilateral neck on contralateral neck metastasis and prognosis of laryngeal cancer]. | to evaluate the impact of extracapsular lymph node spread (ecs) in the ipsilateral neck on the contralateral neck metastasis and prognosis of laryngeal cancer. | 2006 | 17416015 |
| breast-conserving surgery for t3/t4 breast cancer: an analysis of 196 patients. | breast conservation therapy (bct) increases quality of life and self-esteem of breast cancer patients. in special cancer centers up to 90% of patients are treated with bct. t3/t4 breast cancer is one of the few contraindications for bct. however, retrospective data suggest that bct may be eligible in selected cases of t3/t4 breast cancer. | 2007 | 17417725 |
| inhibition of tyrosine kinase-mediated cellular signalling by tyrphostins ag126 and ag556 modulates secondary damage in experimental spinal cord trauma. | protein tyrosine kinases help to regulate the expression of many genes, which play an important role in the pathophysiology of a number of diseases. here we investigate the effects of the tyrosine kinase inhibitors, ag126 and ag556 on the degree of experimental spinal cord trauma induced by the application of vascular clips to the dura via a four-level t4-t8 laminectomy. spinal cord injury in mice resulted in severe trauma characterized by oedema, neutrophil infiltration, production of a range o ... | 2007 | 17418876 |
| renal cell carcinoma clinically involving adjacent organs: experience with aggressive surgical management. | historically, patients with nonmetastatic renal cell carcinoma (rcc) involving adjacent organs have been considered inoperable and incurable. the oncologic efficacy of an aggressive surgical approach was evaluated in a selected subpopulation of rcc patients. further, an attempt was made to define the clinical and pathologic characteristics predictive of surgical failure. | 2007 | 17420980 |
| clearing of suspensions of micrococcus lysodeikticus catalysed by lysozymes from hen, goose, and turkey egg whites, human milk, and phage t4. assessment of potential as signal generators for homogeneous enzyme immunoassays for urinary steroids. | lysozymes (3.2.1.17) from goose (anser anser) egg white, turkey (melagris gallopavo) egg white, phage t4 and human milk were compared with hen egg white lysozyme in their ability to clear a suspension of micrococcus lysodeikticus. all of the lysozymes, except hen egg white lysozyme, catalysed the clearing of the micrococcus lysodeikticus suspension in a biphasic fashion. compared to hen egg white lysozyme, the total absorbance or transmission change over 5 and 20 minutes was less in all cases, e ... | 2007 | 17424827 |
| comparison of seven serum thyroglobulin assays in the follow-up of papillary and follicular thyroid cancer patients. | serum thyroglobulin (tg) is the marker of differentiated thyroid cancer after initial treatment and tsh stimulation increases its sensitivity for the diagnosis of recurrent disease. | 2007 | 17426102 |
| hypermutagenesis in muta cells is mediated by mistranslational corruption of polymerase, and is accompanied by replication fork collapse. | elevated mistranslation induces a mutator response termed translational stress-induced mutagenesis (tsm) that is mediated by an unidentified modification of dna polymerase iii. here we address two questions: (i) does tsm result from direct polymerase corruption, or from an indirect pathway triggered by increased protein turnover? (ii) why are homologous recombination functions required for the expression of tsm under certain conditions, but not others? we show that replication of bacteriophage t ... | 2006 | 17427291 |
| [malignant neoplasm of nose and paranasal sinuses in lower silesia in years 1992-2001]. | malignant neoplasms of the nose and paranasal sinuses occur rarely but due to late diagnosis and poor treatment effects still remain a serious problem. the aim of the study was the analysis of all nose and paranasal sinus neoplasms treated at lower silesia in the years 1992-2001. | 2006 | 17427494 |
| an atp hydrolysis sensor in the dna packaging motor from bacteriophage t4 suggests an inchworm-type translocation mechanism. | tailed bacteriophages and large eukaryotic viruses employ powerful molecular motors to translocate dsdna into a preassembled capsid shell. the phage t4 motor is composed of a dodecameric portal and small and large terminase subunits assembled at the special head-tail connector vertex of the prohead. the motor pumps dna through the portal channel, utilizing atp hydrolysis energy provided by an atpase present in the large terminase subunit. we report that the atpase motors of terminases, helicases ... | 2007 | 17428497 |
| thyroid dysfunction associated with increased low-density lipoprotein cholesterol in epileptic children treated with carbamazepine monotherapy: a causal relationship? | lipid abnormalities and thyroid dysfunction have been reported in patients treated with antiepileptic drugs. the aim of this study was to evaluate prospectively the association between thyroid and lipid profile in children treated with carbamazepine (cbz) monotherapy. | 2007 | 17428707 |
| hypopharyngeal carcinoma: king faisal specialist hospital and research centre experience. | from 1975 to 1985, 202 patients with hypopharyngeal cancer were seen at king faisal specialist hospital and research centre (kfsh&rc). the endoscopic investigation showed that 28.3% of these patients had postcricoid carcinoma; 19.85% had pyriform fossa carcinoma and 52.9% had involvement of both sites. the pathological diagnosis of all cases was squamous cell carcinoma type. the majority of the patients (62.98%) had t4 lesions, which showed a late presentation to kfsh&rc. information related to ... | 1996 | 17429239 |
| an evidence-based review of poorly differentiated thyroid cancer. | poorly differentiated thyroid cancer (pdtc) presents the endocrinologist and surgeon with challenges of recognition and treatment given the lack of consensus on histopathologic definition and limited literature on surgical and nonsurgical treatment. | 2007 | 17431717 |
| [methods and tools for parasite differentiation within the genus trichinella]. | this review summarizes the major biological, biochemical and molecular methods which have been developed during last 20 years to distinguish parasites of the genus trichinella. from the time of the discovery of trichinella in 1835 until the 1970, it was assumed that trichinellosis was caused by a single species of parasite, trichinella spiralis. many biological parameters have been compared to differentiate the parasite, such as host specificity, geographical distribution, reproductive abilities ... | 2006 | 17432239 |
| [effects of shenfu injection on inflammatory cytokines during cardiopulmonarbypass in infants]. | to evaluate the effects of shenfu injection (sf) on cytokines during cardiopulmonary bypass (cpb) in infants. | 2007 | 17432678 |
| removal of particle-associated bacteriophages by dual-media filtration at different filter cycle stages and impacts on subsequent uv disinfection. | this bench-scale study investigated the passage of particle-associated bacteriophage through a dual-media (anthracite-sand) filter over a complete filter cycle and the effect on subsequent ultraviolet (uv) disinfection. two model viruses, bacteriophages ms2 and t4, were considered. the water matrix was de-chlorinated tap water with either kaolin or aldrich humic acid (aha) added and coagulated with alum to form floc before filtration. the turbidity of the influent flocculated water was 6.4+/-1.5 ... | 2007 | 17433406 |
| evaluation of the surgical completeness after total thyroidectomy for differentiated thyroid carcinoma. | to quantify the rate of patients without thyroid remnants, to identify predictive factors for the absence of residual thyroid tissue and to evaluate number, site, size and function of thyroid remnants after total thyroidectomy for differentiated thyroid carcinoma (dtc). | 2007 | 17433606 |
| [hoffmann syndrome presenting to the emergency department]. | we report a case of hypothyroid myopathy, or hoffmann syndrome, in a 31-year-old man who presented to the emergency department with asthenia, muscular pain, cramps, and joint pain. tests revealed increased creatine phosphokinase level (8102 u/l) and severe hypothyroidism (content of t4=3.8 pg/ml, t3=1.3 pg/ml, and thyrotropin stimulating hormone>150 microu/ml). other causes of myopathy were excluded by anamnestic investigation and paraclinical exam. treatment was begun with thyroid hormones (fro ... | 2007 | 17434641 |
| variable responses of acanthamoeba strains to three multipurpose lens cleaning solutions. | a novel method has been developed to compare acanthamoeba strain differences by testing their susceptibility to multipurpose contact lens cleaning solutions (mps). | 2007 | 17435534 |
| management of low-risk patients with thyroid carcinoma and detectable thyroglobulin on t4 after thyroidectomy and ablation with iodine-131. | to evaluate the positive predictive value of detectable tg during t4 therapy (tg on t4) in patients with thyroid cancer after total thyroidectomy and remnant ablation, discussing the work-up in this situation and the empirical indication of 131i. | 2007 | 17435862 |
| radiographic measures of thoracic kyphosis in osteoporosis: cobb and vertebral centroid angles. | several measures can quantify thoracic kyphosis from radiographs, yet their suitability for people with osteoporosis remains uncertain. the aim of this study was to examine the validity and reliability of the vertebral centroid and cobb angles in people with osteoporosis. | 2007 | 17437103 |
| prognostic accuracy of an artificial neural network in patients undergoing radical cystectomy for bladder cancer: a comparison with logistic regression analysis. | to compare the prognostic performance of an artificial neural network (ann) with that of standard logistic regression (lr), in patients undergoing radical cystectomy for bladder cancer. | 2007 | 17437435 |
| robotic radical prostatectomy: outcomes of 500 cases. | to report the outcomes of 500 robotically assisted laparoscopic radical prostatectomies (ralps), a minimally invasive alternative for treating prostate cancer. | 2007 | 17437441 |
| the adaptation and relationship of fgf-23 to changes in mineral metabolism in graves' disease. | the aim of this study was to observe the changes in bone and mineral metabolism and to confirm the regulation of fibroblast growth factor-23 (fgf-23) in untreated graves' disease. | 2007 | 17437520 |
| influence of the endodontic treatment on mechanical properties of root dentin. | this study evaluated the effect of endodontic treatment and storage time on the flexural and ultimate tensile strength of root dentin. eighty bovine teeth were divided into endodontically treated (et) and endodontically untreated (nt) teeth. the et canals were instrumented and irrigated with sodium hypochlorite 1.0%. roots were filled with gutta-percha and zinc-oxide/eugenol cement by the lateral condensation technique. tests were performed as follows: t1, immediately; t2, 7 days; t3, 15 days; a ... | 2007 | 17437882 |
| sex differences in the long-term outcome after a severe thermal injury. | we have recently shown that during the acute phase, postburn female pediatric burn patients had significantly increased levels of anabolic hormones with an associated decreased hypermetabolism leading to a significant shorter intensive care unit stay compared with male patients. the aim of the present study was to determine possible differences between girls and boys in body composition, hypermetabolism, and hormone pattern in the long term. sixty-two children (1-16 years old) who sustained a se ... | 2007 | 17438449 |
| inhibitory effect on replicative dna polymerases, human cancer cell proliferation, and in vivo anti-tumor activity by glycolipids from spinach. | we succeeded in purifying a major glycolipids fraction (i.e., fraction-ii) in the class of monogalactosyl diacylglycerol (mgdg), digalactosyl diacylglycerol (dgdg) and sulfoquinovosyl diacylglycerol (sqdg) from spinach using hydrophobic column chromatography. fraction-ii inhibited the activities of replicative dna polymerases (pols) such as alpha, delta and epsilon, and mitochondrial pol gamma with ic(50) values of 43-79 microg/ml, but had no influence on the activity of repair-related pols beta ... | 2007 | 17439396 |
| bexarotene-induced hypothyroidism: bexarotene stimulates the peripheral metabolism of thyroid hormones. | therapy with the retinoid x receptor agonist bexarotene is associated with hypothyroidism caused by decreased pituitary tsh secretion. to evaluate the effects of bexarotene on peripheral thyroid hormone metabolism, we performed a study in athyreotic subjects on a fixed substitution dose with l-t4. | 2007 | 17440015 |
| characterization of a novel t4-type stenotrophomonas maltophilia virulent phage smp14. | stenotrophomonas maltophilia (sm), with most of the isolates being resistant to multidrugs, is an opportunistic bacterium causing nosocomial infections. in this study, a novel virulent sm phage, smp14, was characterized. electron microscopy showed that smp14 resembled members of myoviridae and adsorbed to poles of the host cells during infection. it lysed 37 of 87 clinical sm isolates in spot test, displayed a latent period of ca. 20 min, and had a burst size of ca. 150. its genome (estimated to ... | 2007 | 17440710 |
| treatment of thoracic esophageal carcinoma invading adjacent structures. | t4 esophageal cancer is defined as the tumor invading adjacent structures, using tumor-node-metastasis (tnm) staging. for clinically t4 thoracic esophageal carcinoma, multimodality therapy, that is, neoadjuvant chemoradiotherapy (crt) followed by surgery or definitive crt, has generally been performed. however, the prognosis of patients with these tumors remains poor. another strategy is needed to achieve curative treatment. in the present article, the treatment strategies employed to date are r ... | 2007 | 17441965 |
| serum osteoprotegerin and soluble receptor activator of nuclear factor kappab ligand levels in patients with a history of differentiated thyroid carcinoma: a case-controlled cohort study. | overt hyperthyroidism is associated with changes in bone metabolism, whereas the effect of levothyroxine (l-t4) load in patients with differentiated thyroid carcinoma (dtc) is controversial. the aim of our study was to evaluate osteoprotegerin (opg) and soluble receptor activator of nuclear factor kappab ligand (rank-l) in patients with dtc with suppressed endogenous thyrotropin due to l-t4 regimen. a cohort of 80 subjects with dtc (68 women and 12 men; age range, 27-81 years) was studied. a coh ... | 2007 | 17445547 |
| oncologic control after open or laparoscopic nephroureterectomy for upper urinary tract transitional cell carcinoma: a single center experience. | to determine the surgical and oncologic outcomes in patients who underwent either open nephroureterectomy (onu) or laparoscopic nephroureterectomy (lnu) for upper urinary tract transitional cell carcinoma. | 2007 | 17445646 |
| pleural effusion in patients with non-small cell carcinoma--stage iv and not t4. | | 2007 | 17445946 |
| immunolocalisation of members of the polypeptide n-acetylgalactosaminyl transferase (ppgalnac-t) family is consistent with biologically relevant altered cell surface glycosylation in breast cancer. | an extensive family of udp-n-alpha-d-galactosamine: polypeptide n-acetylgalactosaminyltransferases (polypeptide n-acetylgalactosaminyltransferases, ppgalnac-t's) catalyse the attachment of the first n-acetylgalactosamine (galnac) monosaccharide to the polypeptide at the initiation of o-linked glycosylation of proteins. some members of the family are broadly expressed while others are more restricted in their distribution, their expression and activity being confined to certain cells or tissues, ... | 2007 | 17448526 |
| aqueous two-phase recovery of bio-nanoparticles: a miniaturization study for the recovery of bacteriophage t4. | biotechnology industry has recently been demanding nanoparticulate products (20-200 nm) such as viruses, plasmids, virus-like particles and drug delivery assemblies. these products are mainly used as gene delivery systems in gene therapy protocols. during the process development for the manufacture of these products, it is crucial to optimize the recovery and purification steps. unfortunately, the high value of some bio-nanoparticles complicates the optimization studies. the solvent extraction m ... | 2007 | 17448735 |
| secretory immunoglobulin a (siga) deficiency in serum of patients with galtectomy (appendectomy and tonsillectomy). | in adult human beings, 80-85% of the immune cells are located in the digestive tract mucosa; hence the importance of the gut associated lymphoid tissue (galt) in host defence. we studied the influence of the surgical removal of two important parts of the gut associated with lymphoid tissue (tonsillectomy and appendectomy) on immune parameters. | 2007 | 17449327 |
| multiple controls regulate the expression of mobe, an hnh homing endonuclease gene embedded within a ribonucleotide reductase gene of phage aeh1. | mobile genetic elements have the potential to influence the expression of genes surrounding their insertion site upon invasion of a genome. here, we examine the transcriptional organization of a ribonucleotide reductase operon (nrd) that has been invaded by an hnh family homing endonuclease, mobe. in aeromonas hydrophila phage aeh1, mobe has inserted into the large-subunit gene (nrda) of aerobic ribonucleotide reductase (rnr), splitting it into two smaller genes, nrda-a and nrda-b. this gene org ... | 2007 | 17449612 |
| ubiquitination-induced conformational change within the deiodinase dimer is a switch regulating enzyme activity. | ubiquitination is a critical posttranslational regulator of protein stability and/or subcellular localization. here we show that ubiquitination can also regulate proteins by transiently inactivating enzymatic function through conformational change in a dimeric enzyme, which can be reversed upon deubiquitination. our model system is the thyroid hormone-activating type 2 deiodinase (d2), an endoplasmic reticulum-resident type 1 integral membrane enzyme. d2 exists as a homodimer maintained by inter ... | 2007 | 17452445 |
| thyroid storm induced by trauma due to spear fishing-gun trident impaction in the neck. | a rare case of thyroid storm induced by thyroid gland injury because of penetrating neck trauma is reported. the injury was because of a spear fishing-gun trident impaction in the neck. the diagnosis of thyroid gland injury was suspected by preoperative clinical examination and established during neck exploration in the theatre. the gland injury led to thyroid storm owing to the rupture of acini and liberation of t4 into the bloodstream. withdrawal of the impacted trident along with subtotal thy ... | 2007 | 17452705 |
| therapeutic outcomes of laryngeal cancer at kyoto university hospital for 10 years. | it is important to prevent regional lymph node recurrence and distant metastasis to achieve better survival of laryngeal cancer. | 2007 | 17453448 |
| subclinical hyperthyroidism as a potential factor for dysfunctional uterine bleeding. | to evaluate the functional status of the thyroid gland in apparently euthyroid women with dysfunctional uterine bleeding. | 2007 | 17454153 |
| the effects of acute stress and pubertal development on metabolic hormones in the rat. | a dramatic change in stress responsiveness occurs during pubertal development such that stress-induced corticosterone secretion in prepubertal animals takes 45-60 min longer to return to baseline compared to adults. though corticosterone is known to influence energy mobilization, it is presently unknown whether stressors affect other hormones important in energy utilization and metabolism differentially in animals before and after pubertal development. therefore, we exposed prepubertal (28 days ... | 2007 | 17454971 |
| [automatic auditory information management in panic disorder patients: an event-related potentials study]. | to investigate the characteristics of automatic auditory information management in sufferers of panic disorder (pd). | 2007 | 17456362 |
| epigenetic reversion of breast carcinoma phenotype is accompanied by changes in dna sequestration as measured by alui restriction enzyme. | the importance of microenvironment and context in regulation of tissue-specific genes is well established. dna exposure to or the sequestration from nucleases detects differences in higher order chromatin structure in intact cells without disturbing cellular or tissue architecture. to investigate the relationship between chromatin organization and tumor phenotype, we used an established three-dimensional assay in which normal and malignant human breast cells can be easily distinguished by the mo ... | 2007 | 17456778 |
| primary hyperparathyroidism. a rare cause of spinal cord compression. | we report a case of a 62-year-old postmenopausal hypertensive lady who was treated for osteoporosis with calcium and vitamin d. she presented with progressive lower limb weakness and paresthesia with sensory level at t4. investigations revealed high parathyroid hormone 1152 ng/dl, calcium 10.9 mg/dl, and low phosphorus of 2.4 mg/dl after stopping calcium supplement. chest x-ray showed an expansile mass lesion of the right 6th rib confirmed by chest ct. thoracic mri showed a mass lesion extending ... | 2007 | 17457452 |
| characteristics of activation in the parietal areas of the cortex in humans in different types of visual attention. | the state of cortical activation in the parietal and temporal areas was assessed using evoked potentials (ep) during the tasks of selection of lateralized visual stimuli requiring three different types of attention: to stimulus shape, to stimulus position, and to both. studies in 15 young, healthy subjects involved recording of ep in six cortical leads: p3, p4, t3, t4, t5, and t6, with analysis of the endogenous ep components cnv, n1, p3, and the ep complex [n1-p3] (according to standard termino ... | 2007 | 17457527 |
| isolation of potentially pathogenic strains of acanthamoeba in wild squirrels from the canary islands and morocco. | in this study, a survey was conducted in order to determine the presence and pathogenic potential of free-living amoebae of acanthamoeba genus in a population of barbary ground squirrels in fuerteventura island (canary islands, spain) and morocco. identification of acanthamoeba was based on the morphology of cyst and trophozoite forms and pcr amplification with a genus specific primer pair. the pathogenic potential of acanthamoeba isolates was characterized using pcrs with two primer pairs relat ... | 2007 | 17459380 |
| a randomized trial of pet scanning to improve diagnostic yield of direct laryngoscopy in patients with suspicion of recurrent laryngeal carcinoma after radiotherapy. | the relaps study (recurrent laryngeal carcinoma pet study) was designed to determine whether fdg-pet is of value in the selection of patients for direct laryngoscopy under general anesthesia in patients with suspicion of recurrent laryngeal carcinoma after radiotherapy. in a randomized controlled clinical trial the current diagnostic practice, i.e. all patients undergo direct laryngoscopy, will be compared to a strategy in which fdg-pet selects the patients for laryngoscopy. all eight head and n ... | 2007 | 17459783 |
| upregulation of hypoxia inducible factor 1alpha mrna is associated with elevated vascular endothelial growth factor expression and excessive angiogenesis and predicts a poor prognosis in gastric carcinoma. | to investigate the implication of the hypoxia inducible factor hif-1alpha mrna in gastric carcinoma and its relation to the expression of vascular endothelial growth factor (vegf) protein, tumor angiogenesis invasion/metastasis and the patient's survival. | 2007 | 17461470 |
| electrochemistry, spectroscopy, and electrogenerated chemiluminescence of some star-shaped truxene-oligofluorene compounds. | we report electrochemical studies, spectroscopy, and electrogenerated chemiluminescence (ecl) of four monodisperse star-shaped truxene core-oligofluorene compounds (t1-t4). all oligomers produced stable radical anions and radical cations and showed blue ecl by ion annihilation with an intensity that could be seen with the naked eye. ecl spectra showed that all ecl emissions were at the same position as the fluorescence emission, except for t1, the compound with the shortest fluorene arms that pr ... | 2007 | 17461571 |
| thyroid dysfunction in infertile women. | objective: to determine the frequency of thyroid dysfunction in infertile women referred for thyroid evaluation. design: a retrospective case-control study. place and duration of study: this study was carried out at centre for nuclear medicine (cenum), mayo hospital, lahore, from july 2003 to december 2006. patients and methods: age matched infertile (n=140 each) and fertile women (n=152 each) referred to cenum for thyroid evaluation were investigated for incidence of hyperthyroidism (tsh < 0.03 ... | 2007 | 17462173 |
| complete pathological response to bevacizumab and chemoradiation in advanced rectal cancer. | localized rectal cancer responds well to 5-fluorouracil and radiation-based regimens. a phase i-ii trial is currently testing the efficacy of adding bevacizumab, a vegf-specific antibody, to standard chemoradiotherapy. the case presented here is a complete pathological response seen in a patient with extensive and locally invasive carcinoma after receiving this combined treatment. | 2007 | 17464339 |
| staging laparoscopy for advanced gastric cancer: is it also useful for the group which has an aggressive surgical strategy? | staging laparoscopy has been shown to be useful for increasing the accuracy of preoperative staging. however, controversy still exists regarding patient selection and subsequent treatment. the aim of this study was to determine the role of staging laparoscopy for a group that has a policy to perform aggressive surgery for advanced gastric cancer. | 2007 | 17464538 |
| association of serum vascular endothelial growth factor-c and lymphatic vessel density with lymph node metastasis and prognosis of patients with gastric cancer. | to investigate whether serum vascular endothelial growth factor-c (svegf-c), vegf-c, and lymphatic vessel density (lvd) in tumor tissues are related to lymph node metastasis (lnm) and prognosis in gastric cancer. | 2007 | 17465468 |
| ethnic differences in tsh but not in free t4 concentrations or tpo antibodies during pregnancy. | to describe the tsh, free t4 and thyroid peroxidase antibody (tpo-ab) concentrations during pregnancy among four ethnic groups and to determine reference values for these parameters during normal pregnancy. | 2007 | 17466012 |
| thyroid hormone deficiency and postmenopausal status independently increase serum osteoprotegerin concentrations in women. | to study the impact of thyroxine (t4) withdrawal on serum osteoprotegerin concentrations in women, using a healthy euthyroid control group matched for age and postmenopausal status as reference. subjects and design: nineteen women with differentiated thyroid carcinoma were studied the last day on t4 suppressive treatment, 4-7 days after withdrawal and the day before whole body scanning. eighteen women matched for age and postmenopausal status served as controls. serum thyroid hormones, urinary b ... | 2007 | 17468189 |
| functional output improvement in fes cycling by means of forced smooth pedaling. | investigation of the influence of forced smooth and normal (nonsmooth) pedaling on the functional output of outdoor functional neuromuscular electrical stimulation (fes)-propelled cycling of spinal cord-injured subjects. | 2007 | 17468573 |
| an evaluation of densitometric vertebral fracture assessment in men. | the utility of, and potential indications for, densitometric vertebral fracture assessment were evaluated in 1,168 men. a bimodal fracture distribution was observed, identifying fractures in 17% of men with no fracture history. osteopenia or height loss of > or = 2.5'' may be indications for vfa in men. | 2007 | 17468808 |
| diagnosis and surgical management of gallbladder cancer: a review. | gallbladder cancer is one of the most lethal carcinomas and continues to pose many challenges for surgeons. identifiable risk factors for carcinoma of the gallbladder include cholelithiasis, an anomalous pancreaticobiliary junction, and focal mucosal microcalcifications. adenocarcinoma is the primary histologic type in most patients and the tumor is frequently associated with kras and p53 mutations. radiologic and endoscopic advances in endoscopic ultrasonography and magnetic resonance cholangio ... | 2007 | 17468929 |
| measurement of thyroid hormones (thyroxine, t4; triiodothyronine, t3) in captive nondomestic felids. | the aim of this research was to obtain basic values for the evaluation of thyroid function in nondomestic felids. serum thyroid hormone concentrations (thyroxine, t4; triiodothyronine, t3) were measured by radioimmunoassay in 145 cats, representing nine species of captive nondomestic felids: jaguar (panthera onca), n = 49; puma (puma concolor), n = 10; ocelot (leopardus pardalis), n = 22; oncilla (leopardus tigrinus), n = 12; geoffroy (oncifelis geoffroyi), n = 4; jaguarundi (herpailurus yaguaro ... | 2007 | 17469287 |
| video-assisted thoracoscopic anterior surgery for tuberculous spondylitis. | in the absence of major deformity, the major goal of surgery in tuberculous spondylitis is to achieve adequate cord decompression and débridement of diseased tissue. we asked whether video-assisted thoracoscopic surgery (vats) could be undertaken in active tuberculosis of the spine with instrumentation and achieve good healing of the disease with fusion and with adequate decompression of the cord to achieve neural recovery. we retrospectively reviewed 23 patients (13 men and 10 women with an ave ... | 2007 | 17471105 |
| regional recurrences of n0 primary laryngeal cancer: a retrospective study of fiveyear period. | to analyse the stage of nodal neck recurrences when first encountered and to determine the relevance of selective lateral neck dissection by retrospective review of patients with regional recurrence. | 2003 | 17472259 |
| structural determinants of nitroxide motion in spin-labeled proteins: tertiary contact and solvent-inaccessible sites in helix g of t4 lysozyme. | a nitroxide side chain (r1) has been substituted at single sites along a helix-turn-helix motif in t4 lysozyme (residues 114-135). together with previously published data, the new sites reported complete a continuous scan through the motif. mutants with r1 at sites 115 and 118 were selected for crystallographic analysis to identify the structural origins of the corresponding two-component epr spectra. at 115, r1 is shown to occupy two rotamers in the room temperature crystal structure, one of wh ... | 2007 | 17473014 |
| health status, mood, and cognition in experimentally induced subclinical hypothyroidism. | the objective of the study was to determine whether subclinical hypothyroidism causes decrements in health status, mood, and/or cognitive function. | 2007 | 17473069 |
| overexpression of fascin-1 in advanced colorectal adenocarcinoma: tissue microarray analysis of immunostaining scores with clinicopathological parameters. | fascin-1 is an actin-binding protein that promotes cell proliferation, adhesion and motility. we tested the hypothesis that fascin-1 expression correlates with clinicopathological parameters of colorectal adenocarcinomas. | 2007 | 17473384 |
| morphological and physiological development of anterior thoracic stretch receptors in two isopods, armadillidium vulgare and ligia exotica. | abdominal muscle receptor organs (mros) monitor the position and movement of abdomen in crustaceans. thoracic segments of decapods are fused and immovable. it is speculated that mros had retrograded simple shape, n-cells that lost receptor muscles, a receptor cell and accessory nerves. we focused on the effect of segmental movement in respect to thoracic n-cells and mros in isopods that have movable thoracic segments. armadillidium vulgare rolled up its body segments. ligia exotica swam by quick ... | 2007 | 17473927 |
| laparoscopic colectomy in colon cancer. a single-center clinical experience. | aim of our study was to compare the results of the laparoscopic technique to those obtained by traditional open approach in patients with colon cancer. the advantages, disadvantages, and the contraindications (real and presumptive) of this mini-invasive approach are described, by comparing the data obtained from the international literature with our clinical experience. | 2007 | 17475112 |
| [confocal microscopic evaluation of epithelia of the larynx]. | to evaluate mucosal changes of the true vocal cord, e. g. leukoplakia, microlaryngoscopy is needed to obtain tissue for histopathologic investigation. but there is a discrepancy between the amount of representative tissue necessary for pathology and the postoperative voice function. thus, a diagnostic procedure that enables the surgeon to differentiate inflammation from dysplasia and carcinoma in situ intra-operatively is urgently needed. we are now reporting on our results using laser scanning ... | 2007 | 17476630 |
| [regulation of promoter activity through electrostatic interactions with rna-polymerase]. | electrostatic profiles for sigma70-specific promoters of t4 bacteriophage and four consensus-like synthetic promoters have been calculated. it was shown that the promoters can be classified according to the presence of some specific electrostatic elements located in the far upstream region of their dnas. a correlation between the electrostatic elements specific for promoters and their functional behaviour was established. a general scheme of promotor activity regulation through electrostatic int ... | 2007 | 17477049 |
| clinical presentation, management, and outcome of high-grade mucoepidermoid carcinoma of the parotid gland. | to describe clinical features of high-grade (hg) mucoepidermoid carcinoma (mec) of the parotid gland and assess clinical outcomes of one surgical management approach. design/setting/methods: retrospective case series in a tertiary care academic institution. pathology records were reviewed from 1977 to 1997, identifying patients with parotid hg mec. available medical records were reviewed for data on clinical features, treatment, and outcome. | 2007 | 17478216 |
| prognostic significance of surgical margins in transoral co2 laser microsurgery for t1-t4 pharyngo-laryngeal cancers. | histological affected or close margin is an adverse factor in conventional surgery of larynx-hypopharynx cancer. our objective was to analyze the relevance of the margins in transoral laser microsurgery (tlm). a retrospective study of 357 consecutive patients with cancer of the larynx and hypopharynx (t1-t4) treated with tlm. three possible margins were considered: tumor free, affected, and uncertain. an affected margin showed marked tumor infiltration. an uncertain margin was defined when the s ... | 2007 | 17479274 |
| twenty-four hour hormone profiles of tsh, free t3 and free t4 in hypothyroid patients on combined t3/t4 therapy. | the benefits of using thyroxine (t4) plus triiodothyronine (t3) in combination in thyroid hormone replacement are unproven but many individuals continue to be treated with this regime. when t3 is used alone for hypothyroidism, it results in wide fluctuations of thyroid hormone levels. however, only limited data exists on combined t3/t4 therapy. in this study, we have compared 24-hour profiles of thyroid stimulating hormone (tsh), free t4 (ft4) and free t3 (ft3) and cardiovascular parameters in 1 ... | 2007 | 17479444 |