| gemcitabine and cisplatin in a concomitant alternating chemoradiotherapy program for locally advanced head-and-neck cancer: a pharmacology-guided schedule. | administration of gemcitabine together with cisplatin at cytotoxic doses in a chemoradiotherapy regimen is hampered by a high degree of local toxicity. using the pharmacologic properties of the drug we designed a modified schedule aimed at reducing toxicity while preserving activity. | 2006 | 17011449 |
| evaluation of ammonium perchlorate in the endocrine disruptor screening and testing program's male pubertal protocol: ability to detect effects on thyroid endpoints. | the u.s. epa endocrine disruptor screening program (edsp) tier 1 male pubertal protocol was designed as a screen to detect endocrine-disrupting chemicals which may alter reproductive development or thyroid function. one purpose of this in vivo screening protocol is to detect thyrotoxicants via a number of different mechanisms of action, such as thyroid hormone synthesis or clearance. here we evaluate the ability of this edsp male pubertal protocol to detect the known thyrotoxicant ammonium perch ... | 2006 | 17011691 |
| crystallization and preliminary x-ray analysis of bacteriophage t4 uvsy recombination mediator protein. | bacteriophage t4 uvsy protein is considered to be the prototype of recombination mediator proteins, a class of proteins which assist in the loading of recombinases onto dna. wild-type and se-substituted uvsy protein have been expressed and purified and crystallized by hanging-drop vapor diffusion. the crystals diffract to 2.4 a using in-house facilities and to 2.2 a at nsls, brookhaven national laboratory. the crystals belong to space group p422, p4(2)22, p42(1)2 or p4(2)2(1)2, the ambiguity ari ... | 2006 | 17012799 |
| acanthamoeba keratitis due to acanthamoeba genotype t4 in a non-contact-lens wearer in turkey. | an otherwise healthy 22-year-old man presented with acanthamoeba keratitis (ak) in the right eye. he was not a contact lens wearer and had no history of corneal trauma. the acanthamoeba strain isolated from a corneal scraping was identified as morphological group ii and genotype t4. three more acanthamoeba strains isolated from sites of possible human contact with acanthamoebae in the same geographical region, including a lens storage case, tap water and soil, were subjected to morphological and ... | 2007 | 17013653 |
| spontaneous spinal epidural hematoma in a 4-month-old infant. | a case report and a review of literature. | 2007 | 17016493 |
| rna ligase structures reveal the basis for rna specificity and conformational changes that drive ligation forward. | t4 rna ligase 2 (rnl2) and kinetoplastid rna editing ligases exemplify a family of rna repair enzymes that seal 3'oh/5'po(4) nicks in duplex rnas via ligase adenylylation (step 1), amp transfer to the nick 5'po(4) (step 2), and attack by the nick 3'oh on the 5'-adenylylated strand to form a phosphodiester (step 3). crystal structures are reported for rnl2 at discrete steps along this pathway: the covalent rnl2-amp intermediate; rnl2 bound to an adenylylated nicked duplex, captured immediately fo ... | 2006 | 17018278 |
| diagnostic value of multidetector row ct in rectal cancer staging: comparison of multiplanar and axial images with histopathology. | although magnetic resonance (mr) imaging is widely used for rectal cancer staging, many centres in the uk perform computed tomography (ct) for staging rectal cancer at present. furthermore in a small proportion of cases contraindications to mr imaging may lead to staging using ct. the purpose of this study was to evaluate the accuracy of current generation multidetector row ct (mdct) in local staging of rectal cancer. in particular the accuracy of multiplanar (mpr) versus axial images in the sta ... | 2006 | 17018304 |
| pseudohypoparathyroidism type ia and growth hormone deficiency. growth hormone releasing hormone receptor defect? | we report a boy with pseudohypoparathyroidism (php), hypothyroidism and low growth hormone (gh) values with no response to growth hormone releasing hormone (ghrh). he presented at age 17 mo because of developmental delay. he had the typical features (short stature, obesity, round face, brachydactyly) of albright's hereditary osteodystrophy (aho) and the biochemical profile of php; low serum calcium and high phosphate, raised parathormone (pth) values and lack of response of urinary phosphate and ... | 2002 | 17018438 |
| [thyrotoxicosis and coexistent diseases in atrial fibrillation.] | objective: to evaluate the prevalence of thyrotoxicosis and coexistent diseases in patients with atrial fibrillation admitted to a general medicine ward. material and methods: all patients with the discharge diagnosis of atrial fibrillation were studied. the study design was retrospective for the years 1993-1994 and prospective from april 1995 through december 1997. information on thyroid function tests was obtained from medical records in the retrospective part, but tsh, t4 and t3 were measured ... | 2000 | 17018961 |
| disseminated tumor cells in peripheral blood: a novel marker for therapy response in locally advanced rectal cancer patients undergoing preoperative chemoradiation. | this study was designed to examine whether disseminated tumor cells in peripheral blood of locally advanced rectal cancer patients undergoing preoperative chemoradiation have the potential to serve as a marker for therapy response. studies suggest that patients with advanced rectal cancer who respond to preoperative chemoradiation most likely benefit from this treatment. | 2006 | 17019657 |
| paraplegia as the presenting manifestation of extramedullary megakaryoblastic transformation of previously undiagnosed chronic myelogenous leukemia. | extramedullary tumors, also known as granulocytic sarcomas (gs), occur most frequently in acute myelogenous leukemia (aml). they may signal the onset of the accelerated phase of chronic myelogenous leukemia (cml) or the blastic transformation of a myeloproliferative disorder. occasionally, a gs may be the presenting sign of undiagnosed aml, and rarely the presenting sign of undiagnosed cml or aleukemic leukemia. paraplegia due to a spinal cord gs is an extremely rare presentation of undiagnosed ... | 2007 | 17019692 |
| effects of environmental temperature on thyroid hormones in the barn owl (tyto alba). | the basic patterns of thyroid hormones [thyroxine (t4) and 3,3',5-triiodothyronine (t3)] and the t4 and t3 responses induced by thyrotropin releasing hormone (trh) are reported in captive female barn owls (tyto alba) during the non-breeding period. the main findings of the study, conducted on a total of 10 owls, are as follow: (1) the thyroid gland of barn owl can be stimulated by the classical trh stimulation test. (2) t3 response was much more pronounced both under cold (around 10 degrees c) a ... | 2006 | 17020136 |
| cardio-protective role of terminalia arjuna bark extract is possibly mediated through alterations in thyroid hormones. | terminalia arjuna bark extract is believed to exhibit cardio-protective effects. in the present study we investigated the possible involvement of thyroid hormones in the amelioration of cardiac and hepatic lipid peroxidation (lpo) by a bark extract of the plant in albino rats. while l-thyroxine (l-t4) treatment increased the level of thyroid hormones, heart/body weight ratio as well as cardiac and hepatic lipid peroxidation, simultaneous administration of 21.42 and 42.84 mg/kg of the plant extra ... | 2006 | 17020158 |
| long-term functional outcome of brachytherapy for carcinoma of the mobile tongue: focus on the atrophic change of irradiated tongue. | to assess tongue atrophy and long-term functional outcome of mobile tongue cancer patients after interstitial radiotherapy. | 2006 | 17020894 |
| is time to chemotherapy a determinant of prognosis in advanced-stage ovarian cancer? | clinicians often question when to start chemotherapy after patients undergo surgery for ovarian cancer. a major unproven concern is whether a long postoperative delay reduces the benefits of an extensive procedure and leads to disease progression. our objectives were to evaluate the correlation between clinical and pathologic variables and to evaluate the effect of the "time to chemotherapy" (ttc) interval on survival. | 2007 | 17023033 |
| the role of triiodothyronine-induced substrate cycles in the hepatic response to overnutrition: thyroid hormone as an antioxidant. | overnutrition, by generating reactive oxygen species (ros), produces oxidative stress - an important cause of cellular injury. in the liver, overnutrition begins in the perivenous hepatocytes. to prevent injury, cells must protect themselves against ros accumulation. overnutrition also activates the enzyme deiodinase-1 (d1), which catalyzes the conversion of t4 to t3. d1 is primarily located in the pv region of the liver. thyroid hormone is known to generate substrate cycling. the hypothesis of ... | 2007 | 17023119 |
| assessment of thoracic epidural analgesia during general anesthesia using pupillary reflex dilation: a preliminary study. | pupillary reflex dilation (prd) secondary to noxious stimulation accurately predicts sensory block during combined lumbar epidural/general anesthesia. therefore, the adequacy of prd-guided thoracic epidural infusion during general anesthesia for thoracotomy was studied. | 2006 | 17023285 |
| phase ii trial of preoperative chemoradiation with a hyperfractionated radiation boost in locally advanced rectal cancer. | the purpose of this phase ii study was to prospectively determine the efficacy of preoperative chemoradiation with a hyperfractionated (hfx) rt boost to 61.8 gy in locally advanced rectal cancer. | 2006 | 17023775 |
| adjacent level load transfer following vertebral augmentation in the cadaveric spine. | in vitro biomechanics. | 2006 | 17023840 |
| the importance of classification in sympathetic surgery and a proposed mechanism for compensatory hyperhidrosis: experience with 464 cases. | compensatory hyperhidrosis is the most troublesome side effect and the leading cause of regret with sympathetic surgery. a new classification is proposed to make the procedure more selective and to minimize the side effects and regret rate. also, a proposed mechanism for compensatory hyperhidrosis is discussed. | 2006 | 17024534 |
| intermittent hormone therapy in nonmetastatic prostate cancer. | the object of this study was to evaluate the duration of response to intermittent androgen deprivation (iad) in patients with nonmetastatic recurrent or localized prostate cancer. | 2006 | 17026802 |
| phase ii trial of adjuvant gemcitabine plus cisplatin-based chemotherapy in patients with locally advanced bladder cancer. | despite the general acceptance of gemcitabine/cisplatin in metastatic bladder cancer, its role and tolerability in the adjuvant setting, in which renal insufficiency is common, is unclear. | 2006 | 17026804 |
| comparison of the internal dynamics of globular proteins in the microcrystalline and rehydrated lyophilized states. | natural abundance solid-state 13c-nmr spin-lattice relaxation experiments in the laboratory (t1) and off-resonance rotating (t(1rho)) frames were applied for qualitative comparison of the internal molecular dynamics of barstar, hen egg white lysozyme and bacteriophage t4 lysozyme in both the microcrystalline and the rehydrated (water content is 50% of the protein mass) lyophilized states. the microcrystalline state of proteins provides a better spectral resolution; however, less is known about t ... | 2006 | 17027351 |
| do erythropoietin receptors on cancer cells explain unexpected clinical findings? | recent reports suggest that cancer control may worsen if erythropoietin is administered. we investigated whether erythropoietin receptor expression on cancer cells may correlate with this unexpected finding. | 2006 | 17028293 |
| double-strand break repair in bacteriophage t4: recombination effects of 3'-5' exonuclease mutations. | the role of 3'-5' exonucleases in double-strand break (dsb)-promoted recombination was studied in crosses of bacteriophage t4, in which dsbs were induced site specifically within the riib gene by segc endonuclease in the dna of only one of the parents. frequency of rii+ recombinants was measured in two-factor crosses of the type i x ets1, where ets1 designates an insertion in the riib gene carrying the cleavage site for segc and i's are riib or riia point mutations located at various distances ( ... | 2006 | 17028319 |
| electrophoresis of long dna molecules in linear polyacrylamide solutions. | electrophoresis of long dna (t4 dna; 166 kb, s. pombe chromosomal dna; 3-6 mb) in linear polyacrylamide solutions was investigated by fluorescence microscopy and capillary electrophoresis. in the past studies on electrophoresis of long dna in a polymer solution, it was reported that dna migrates in 'u-shape conformation'. we found that at higher polymer concentrations, the shape of the migrating dna changes from u shape to linear shape ('i-shape conformation'). in the migration mode with the i-s ... | 1998 | 17029695 |
| hormonal effects on the secretion and glycoform profile of corticosteroid-binding globulin. | corticosteroid-binding globulin (cbg) is a plasma glycoprotein that is primarily synthesized in the liver and binds cortisol and progesterone with high affinity. in this study, a cbg secreting hepatocellular carcinoma derived cell line (hepg2) was used to investigate the hormonal regulation of hepatic cbg synthesis. hepg2 cells were grown for 72 h in 30, 300 and 3000 nm concentrations of estradiol (e2), testosterone (t), insulin, thyroxin (t4) and dexamethasone (dmz) and the secreted cbg quantif ... | 2006 | 17029948 |
| rna switches the higher-order structure of dna. | by the direct observation of single duplex dna molecules by fluorescence microscopy, we found that rna molecules have the potential to change discretely the higher-order structure of individual dna molecules between the compact and elongated states. we performed an experiment with a linear giant dna (t4 dna, 166 kbp) and a circular dna (cosmid vector, 42 kbp), and examined the effect of single-strand rna on their conformations under a physiological concentration of spermidine. individual dna cha ... | 1999 | 17030336 |
| [is subclinical hypothyroidism a cardiovascular risk factor?]. | subclinical hypothyroidism defined by the presence of elevated tsh levels but normal free t4 level is a common situation. its consequences on health are yet on debate and the interest of a precocious treatment remains surrounded by controversy. | 2006 | 17030490 |
| atrial angiotensinase activity in hypothyroid, euthyroid, and hyperthyroid rats. | thyroid dysfunction produces marked cardiovascular responses. hypothyroidism and hyperthyroidism cause important changes in the circulating renin-angiotensin system (ras). modifications in cardiac ras have also been involved in cardiovascular alterations. studies have revealed that thyroid hormones activate some components of cardiac ras. angiotensin (ang) peptides are regulated by the activity of several aminopeptidases (ap) called angiotensinases. previous results in our laboratory have demons ... | 2006 | 17031265 |
| effects of chronic angiotensin ii receptor antagonist and angiotensin-converting enzyme inhibitor treatments on neurohormonal levels and haemodynamics during cardiopulmonary bypass. | chronic treatment with renin-angiotensin system (ras) antagonists frequently causes deleterious hypotension during anaesthesia. we compared the effects of angiotensin ii receptor antagonists (ara) and angiotensin-converting enzyme inhibitors (acei) on neurohormonal levels and haemodynamics during cardiopulmonary bypass (cpb). | 2006 | 17032660 |
| detection of thyroid dysfunction in early pregnancy: universal screening or targeted high-risk case finding? | maternal subclinical hypothyroidism during pregnancy is associated with various adverse outcomes. recent consensus guidelines do not advocate universal thyroid function screening during pregnancy but recommend testing high-risk pregnant women with a personal history of thyroid or other autoimmune disorders or with a family history of thyroid disorders. | 2007 | 17032713 |
| prematurity may be a risk factor for thyroid dysfunction in childhood. | children born prematurely and/or small for gestational age (sga) frequently show disturbances in thyroid function. | 2007 | 17032720 |
| long-term outcome of thyroid function after amiodarone-induced thyrotoxicosis, as compared to subacute thyroiditis. | two main forms of amiodarone- induced thyrotoxicosis (ait) exist: type 1 ait is a condition of true hyperthyroidism developing in patients with pre-existing thyroid disorders, and usually requires thyroid ablative treatment. on the other hand, type 2 ait is a form of destructive thyroiditis occurring in normal thyroids, the management of which usually consists in glucocorticoid treatment. | 2006 | 17033257 |
| the role of n-acetylcysteine in lower extremity ischemia/reperfusions. | to evaluate the efficacy of n-acetyl cysteine (nac) in lower extremity ischemia/reperfusion. | 2006 | 17033604 |
| salt wasting, hypotension, polydipsia, and hyponatremia and the level of spinal cord injury. | case control.objective:to test the reported correlation of hypotension, polydipsia, and hyponatremia with higher levels of spinal cord injury (sci). | 2007 | 17033618 |
| adrenocortical response to stress and thyroid hormone status in free-living nestling white storks (ciconia ciconia) exposed to heavy metal and arsenic contamination. | endocrine parameters have proven useful in the detection of early or low-level responses to pollutants. although most of the studies on endocrine modulation have been focused on processes involving gonadal steroids, contaminants may target other parts of the endocrine system as well. in this study we examined the adrenocortical stress response and thyroid hormone status in free-living nestling white storks (ciconia ciconia) in relation to heavy metals (zinc, lead, copper, cadmium) and arsenic le ... | 2006 | 17035132 |
| [the influence of proprioceptive insoles (bourdiol) on the sagittal curvature and inclination of the trunk]. | proprioceptive insoles rely on the concept of réné-jaques bourdiol, a french neurologist. the aim is to modulate plantar surface sensibility and to influence posture and statics of patients: it is hypothesized that the effect of modified afferent sensory input through proprioceptive stimulation of terminal muscle chains will have either a relaxing or stimulating effect on the whole body, which may be realized by affecting the posture. small pads with a thickness of typically 1-3 mm are embedded ... | 2006 | 17036233 |
| [analysis of mono-side sternohyoid myo-osteal flap used in reconstruction after partial laryngectomy]. | to evaluate the reconstruction effect and to investigate applied indication of unilateral sternohyoid muscle flap with hyoid bone in laryngeal carcinoma after partial laryngectomy. | 2006 | 17037012 |
| creatinine, blood urea nitrogen and thyroid hormone levels before and after haemodialysis. | a study was carried out on 57 patients with chronic renal failure in a hospital in kerman city, islamic republic of iran. blood samples were taken before and after haemodialysis to measure blood urea nitrogen and serum creatinine, triiodothyronine (t3) and thyroxine (t4) levels. findings revealed that before dialysis t4 in 11 cases and t3 in 29 cases were lower than the normal range, but after haemodialysis only 3 cases for t4 and 15 cases for t3 were lower than normal levels. the remaining case ... | 2006 | 17037243 |
| is intraoperative touch imprint cytology of sentinel lymph nodes in patients with breast cancer cost effective? | sentinel lymph nodes (slns) are generally evaluated postoperatively, requiring 5-7 days for assessment. slns can also be evaluated intraoperatively by using touch imprint cytology (tic), thus providing the surgeon immediate feedback and allowing for concurrent completion node dissection (cnd) for positive slns. the authors hypothesized that tic, when compared with standard postoperative sln assessment alone, would permit a cost-effective evaluation of slns in patients with clinically node-negati ... | 2006 | 17039501 |
| thyroid hormone resistance: the role of mutational analysis. | the finding of increased thyroxine (t4) and tri-iodothyronine (t3) levels in a patient with normal or increased thyroid-stimulating hormone is unexpected and presents a differential diagnosis between a thyroid-stimulating hormone-secreting pituitary adenoma, generalized resistance to thyroid hormone (rth) and laboratory artefact. without careful clinical and biochemical evaluation, errors may occur in patient diagnosis and treatment. in the case of rth, mutation of the thyroid hormone receptor b ... | 2006 | 17040361 |
| investigation of interleukin 10, 12 and 18 levels in patients with head and neck cancer. | head and neck squamous cell carcinoma (hnscc) is an aggressive epithelial malignancy. it is the most common neoplasm arising in the upper aerodigestive tract. interleukin (il) 12 and il-18 are cytokines which have a major anti-tumour activity via stimulation of a t-helper type 1 (th1) immune response. interleukin 10, a potent antagonist of il-12, is a cytokine which possesses immunosuppressive activity mainly produced via t-helper type 2 (th2) cells. studies of other types of cancer have shown t ... | 2007 | 17040593 |
| effectiveness of a glutaraldehyde formulation in decontamination of dental unit water systems. | dental-medical devices may transmit infections caused by bacteria that are usually found in water distribution systems, and which are difficult to treat and control. high bacterial contamination in the water systems of dental units is due to the presence of biofilm inside the pipes. our study evaluated the efficacy of glutaraldehyde formulated with quarternary ammonium salts (sanicide t4) examined in a previous study, employing a series of assays to confirm or otherwise the results obtained prev ... | 2006 | 17041544 |
| indication and benefit of pelvic sidewall dissection for rectal cancer. | this study was designed to clarify indication and benefit of pelvic sidewall dissection for rectal cancer. | 2006 | 17041749 |
| w4 theory for computational thermochemistry: in pursuit of confident sub-kj/mol predictions. | in an attempt to improve on our earlier w3 theory [a. d. boese et al., j. chem. phys. 120, 4129 (2004)] we consider such refinements as more accurate estimates for the contribution of connected quadruple excitations (t4), inclusion of connected quintuple excitations (t5), diagonal born-oppenheimer corrections (dboc), and improved basis set extrapolation procedures. revised experimental data for validation purposes were obtained from the latest version of the active thermochemical tables thermoch ... | 2006 | 17042580 |
| the lowest singlet-triplet excitation energy of bn: a converged coupled cluster perspective. | the notoriously small x 3pi-a 1sigma+ excitation energy of the bn diatomic has been calculated using high-order coupled cluster methods. convergence has been established in both the one-particle basis set and the coupled cluster expansion. explicit inclusion of connected quadruple excitations t4 is required for even semiquantitative agreement with the limit value, while connected quintuple excitations t5 still have an effect of about 60 cm(-1). still higher excitations only account for about 10 ... | 2006 | 17042596 |
| is subclinical thyroid dysfunction in the elderly associated with depression or cognitive dysfunction? | widespread use of automated sensitive assays for thyroid hormones and thyroid-stimulating hormone (tsh) has increased identification of mild thyroid dysfunction, especially in elderly patients. the clinical significance of this dysfunction, however, remains uncertain, and associations with cognitive impairment, depression, and anxiety are unconfirmed. | 2006 | 17043339 |
| surgical management for upper thoracic spine tumors by a transmanubrium approach and a new space. | the anterior aspect of the upper thoracic spine is a difficult region to approach in spinal surgery. many vital structures including osseus, articular, vascular and nervous ones hinder the exposure. with increasing frequency, spine surgeons are being asked to provide decompression and stabilization in patients with spinal tumors. the traditional exposure is between the esophagus and trachea medially and the left common carotid or the brachiocephalic artery (bca) laterally, and the disadvantages ... | 2007 | 17043896 |
| neuroarthropathy of the wrist in paraplegia: a case report. | neuroarthropathy, also known as charcot joint, is most commonly seen in the spine and other weight-bearing joints in individuals with spinal cord injury (sci). it is rarely seen in the joints of the upper extremities because the pathophysiology of the neuroarthropathy is thought to be significant repetitive trauma such as with weight bearing in an insensate joint. | 2006 | 17044396 |
| effect of selenium supplementation on activity and mrna expression of type 1 deiodinase in mice with excessive iodine intake. | to investigate the effect of selenium supplementation on the selenium status and selenoenzyme, especially the activity and mrna expression of type 1 deiodinase (d1) in mice with excessive iodine (ei) intake and to explore the mechanism of selenium intervention on iodine-induced abnormities. | 2006 | 17044649 |
| endobronchial intratumoral chemotherapy (eitc) followed by surgery in early non-small cell lung cancer with polypoid growth causing erroneous impression of advanced disease. | seventeen patients with (m0) non-small cell lung cancer (nsclc) without distant metastasis were treated by preoperative endobronchial intratumoral chemotherapy (eitc) followed by surgery. preoperative intratumoral chemotherapy was performed for the purpose of either reducing the extent of resection or increasing operability. clinically, in the preliminary diagnostic bronchoscopic examination, the tumor was located in the main stem bronchus closer than 2 cm to the carina [t3] in 12 patients, or a ... | 2006 | 17045361 |
| predictive poor prognostic factors in colonic carcinoma. | five-year survival in rectal cancer has been steadily improving since the introduction of neoadjuvant chemoradiation and total mesorectal excision surgery. in contrast, 5-year survival rates and management of colonic carcinoma remain relatively unchanged. this study aims to identify poor prognostic factors in colonic cancer patients that could potentially be predicted pre-operatively to identify a subset of patients amenable to neoadjuvant treatment strategies. | 2006 | 17045800 |
| structural and functional studies of regb, a new member of a family of sequence-specific ribonucleases involved in mrna inactivation on the ribosome. | the regb endoribonuclease participates in the bacteriophage t4 life cycle by favoring early messenger rna breakdown. regb specifically cleaves ggag sequences found in intergenic regions, mainly in translation initiation sites. its activity is very low but can be enhanced up to 100-fold by the ribosomal 30 s subunit or by ribosomal protein s1. regb has no significant sequence homology to any known protein. here we used nmr to solve the structure of regb and map its interactions with two rna subst ... | 2007 | 17046813 |
| early assessment of hypothalamic-pituitary-gonadal function in patients with congenital hypothyroidism of central origin. | early recognition of gonadotropic dysfunction could enable well-timed growth and maturation and prevent damage to gonads and external genitalia. the adaptation of the dutch neonatal screening program for congenital hypothyroidism in the mid 1990s resulted in enhanced detection of congenital hypothyroidism of central origin (ch-c), with high likelihood of multiple pituitary hormone deficiency, including gonadotropin (gn) deficiency. | 2007 | 17047014 |
| thyroid hormone synthesis and secretion in humans after 80 milligrams of iodine for 15 days and subsequent withdrawal. | in animals, acute iodine administration results in acute intrathyroidal inhibition of iodinations followed by escape of the inhibition if the excessive iodine intake continues. in humans, the intrathyroidal nonhormonal and hormonal iodine concentration after exposure to large doses of iodine for a relatively long period of time is not known. | 2007 | 17047024 |
| mri and endoscopic ultrasonography in the staging of gastric cancer. | to determine the diagnostic precision of endoscopic ultrasounds (eus) and magnetic resonance imaging (mri) in the preoperative staging of gastric cancer. | 2006 | 17048994 |
| a segmental radiological study of the spine and rib--cage in children with progressive infantile idiopathic scoliosis. | the role of rib cage in the development of progressive infantile idiopathic scoliosis (iis) has not been studied previously. no report was found for rib growth in children with iis. these findings caused us to undertake a segmental radiological study of the spine and rib-cage in children with progressive iis. the aim of the present study is to present a new method for assessing the thoracic shape in scoliotics and in control subjects and to compare the findings between the two groups. | 2006 | 17049098 |
| the role of postoperative radiation therapy in carcinoma ex pleomorphic adenoma of the parotid gland. | to evaluate the impact of postoperative radiation therapy on the clinical course of patients with carcinoma ex pleomorphic adenoma of the parotid gland. | 2007 | 17049183 |
| dietary thyroid hormone improves growth and muscle protein accumulation of black-boned chickens. | 1. the objective of the study was to examine the effect of dietary thyroid hormone on performance and muscle protein accumulation of black-boned chickens. 2. a total of 720 1-d-old birds was housed in 24 pens and assigned to 4 diets containing triiodothyronine (t3) at 0, 0.1, 0.3 or 0.5 mg/kg. 3. the trial was split into starter (0 to 4 weeks) and grower (5 to 8 weeks) phases. at the beginning of the grower phase, each pen was split into two; one subgroup was fed basal diet (t3-) and the other c ... | 2006 | 17050100 |
| an approach to crystallizing proteins by synthetic symmetrization. | previous studies of symmetry preferences in protein crystals suggest that symmetric proteins, such as homodimers, might crystallize more readily on average than asymmetric, monomeric proteins. proteins that are naturally monomeric can be made homodimeric artificially by forming disulfide bonds between individual cysteine residues introduced by mutagenesis. furthermore, by creating a variety of single-cysteine mutants, a series of distinct synthetic dimers can be generated for a given protein of ... | 2006 | 17050682 |
| driving and dementia in older adults: implementation and evaluation of a continuing education project. | we aimed to develop and evaluate a multimedia workshop curriculum to educate physicians and other health professionals about (a) driving-related assessment in older adults with dementia, and (b) strategies to encourage driving retirement for impaired individuals. | 2006 | 17050760 |
| melanoma chemoprevention. | despite efforts to promote sun protection behaviors, melanoma incidence continues to increase. the prognosis of advanced melanoma remains extremely poor in spite of treatment advances, emphasizing the importance of exploring additional preventive measures. | 2006 | 17052492 |
| the stability of maxillary osteotomies fixated with biodegradable mesh in orthognathic surgery. | this study measures the stability of maxillary osteotomies fixated with 1-mm biodegradable mesh and screws. | 2006 | 17052589 |
| what influences early hypothyroidism after radioiodine treatment for graves' hyperthyroidism? | the objective of this study was to evaluate the factors influencing the occurrence of early hypothyroidism after radioiodine treatment of graves' hyperthyroidism. | 2006 | 17053385 |
| neo-adjuvant and adjuvant hormone therapy for localised and locally advanced prostate cancer. | hormone therapy for early prostate cancer has demonstrated an improvement in clinical and pathological variables, but not always an improvement in overall survival. we performed a systematic review of both adjuvant and neo-adjuvant hormone therapy combined with surgery or radiotherapy in localised or locally advanced prostate cancer. | 2006 | 17054269 |
| cancer of the gastric stump following distal gastrectomy for cancer. | cancer of the gastric stump (cgs) after distal gastrectomy for cancer has not been characterized in a large study. the aim of this study was to investigate the clinicopathological features and outcome of cgs following distal gastrectomy for cancer. | 2007 | 17054314 |
| accuracy of endoscopic ultrasound staging of gastric cancer in routine clinical practice in singapore. | endoscopic ultrasound has emerged as the leading modality to assess the t and n stage in gastric cancer. this study aimed to assess the accuracy of tn staging by endoscopic ultrasound in routine clinical practice in singapore. | 2006 | 17054580 |
| post-prandial endothelial dysfunction in hypertriglyceridemic subjects: molecular mechanisms and gene expression studies. | triglyceride-rich lipoproteins (tgrls) are a cardiovascular risk factor and induce endothelial dysfunction. in the present study, we investigated the effects of post-prandial tgrls from type iv hyperlipidemic subjects on endothelial activation addressing the effects of the lipoproteins on intracellular pathways and gene expression. | 2007 | 17055512 |
| transient recycling of resected bone to facilitate mandibular reconstruction--a technical note. | mandibular reconstruction requires considerable sculptural skills. the intriguingly complex configuration of the structure is difficult to reproduce. it is thus imperative for surgeons to seek a technique that improves the precision of the reconstruction. | 2006 | 17055734 |
| [survival analysis for localized renal cell carcinoma. prognostic value of 1997 tnm classification]. | the 5th edition of tnm classification for renal cell carcinoma changed the cut-off point of the tumor size for localized tumors, achieving a better distribution of patients with similar survival. nevertheless, because of the variable evolution of renal cell carcinoma, the prognostic significance of tumor size is questioned as a staging criterion in organ-confined renal cell carcinoma. we analyse renal cell carcinoma specific survival and the prognostic significance of tumor size in i and ii stag ... | 2006 | 17058609 |
| number of lymph nodes examined and its impact on colorectal cancer staging. | the status of lymph nodes is the most important prognosticator in colorectal cancer patients. patients with lymph node involvement have a lower survival rate and are candidates for adjuvant therapy. the purpose of our study was to determine the number of lymph nodes that needs to be examined to accurately detect nodal metastasis. we conducted a retrospective study of 151 patients who underwent colorectal cancer operation at harbor-ucla medical center. data from the operative report and pathology ... | 2006 | 17058731 |
| [brain protective effects of ginkgo biloba leaf extract (ginaton) in patients undergoing hypothermic cardiopulmonary bypass]. | to investigate the brain protective effects of ginkgo biloba leaf extract (ginaton) in patients who underwent hypothermic cardiopulmonary bypass (cpb). | 2006 | 17058828 |
| [clinical manifestations and endoscopic characteristics of kaposi's sarcoma in patients with acquired immunodeficiency syndrome]. | kaposi sarcoma may be the initial manifestation of immunodeficiency acquired syndrome (aids )in 30% of patients. the digestive tract is the thirth most affected site after the skin and lymph nodes. | 2005 | 17058981 |
| [correlation of cervical lymphatic metastasis to prognosis of t3-t4 glottic cancer]. | the cervical lymphatic metastasis rate of glottic cancer is low, and has seldom been reported. this study was to explore the factors related to cervical lymphatic metastasis of t3-t4 glottic cancer, and analyze its correlation to prognosis. | 2006 | 17059774 |
| [continuous epidural anesthesia in patients after surgical treatment for scoliosis]. | analgesia after major spinal orthopedic surgery is a problem to be solved. the authors' original procedure for using continuous epidural anesthesia following scoliosis surgery is an effective mode of upgrading the quality of analgesia within the first 24 hours and diminishing postoperative stress. a visual analogue scale was used to evaluate the efficiency of the procedure. the levels of stress hormones (cortisol, t3, and t4) were measured. | 2006 | 17061592 |
| satellite pulmonary nodule in the same lobe (t4n0) should not be staged as iiib non-small cell lung cancer. | treatment of non-small cell lung cancer depends on stage. patients with t4 lesions represent a heterogeneous group. | 2006 | 17062253 |
| single-dose rexinoid rapidly and specifically suppresses serum thyrotropin in normal subjects. | retinoid x receptor agonists (rexinoids) have demonstrated benefit in patients with certain malignancies but appear to cause central hypothyroidism in some patients with advanced cancer. the influence of rexinoids on thyroid function in healthy subjects is not clear. | 2007 | 17062760 |
| hydranencephaly with cholestasis and giant hepatitis. | we present a rare case of hydranencephaly with cholestasis and giant hepatitis. studies for infectious agents were all negative including for the detection of virus in liver tissue by using polymerase chain reaction. although the anterior pituitary functions (cortisol, thyroid stimulating hormone, free t4, human growth hormone) were normal, the patient revealed massive cholestasis and giant hepatitis. | 2006 | 17063118 |
| [neoadjuvant treatment of rectal cancer: towards an individualised therapy]. | neoadjuvant radiation or chemoradiation followed by oncological resection is the current treatment of choice for locally advanced rectal cancer. profound diagnostics are mandatory to stratify patients for neoadjuvant treatment or primary surgery. here, magnetic resonance tomography most probably will become the standard modality due to its ability to predict involvement of the circumferential resection margin during surgery. while the initiation of chemoradiation in t4 rectal cancer and patients ... | 2006 | 17063435 |
| accessory proteins assist exonuclease-deficient bacteriophage t4 dna polymerase in replicating past an abasic site. | replicative dna polymerases, such as t4 polymerase, possess both elongation and 3'-5' exonuclease proofreading catalytic activities. they arrest at the base preceding dna damage on the coding dna strand and specialized dna polymerases have evolved to replicate across the lesion by a process known as tls (translesion dna synthesis). tls is considered to take place in two steps that often require different enzymes, insertion of a nucleotide opposite the damaged template base followed by extension ... | 2007 | 17064253 |
| intratumoral lymphatic vessels and vegf-c expression are predictive factors of lymph node relapse in t1-t4 n0 laryngopharyngeal squamous cell carcinoma. | the presence of intratumoral lymphatic vessels (ilvs) and the expression of vascular endothelial growth factor-c (vegf-c) in tumour cells have been studied as markers of lymphangiogenesis in order to evaluate their role in metastatic dissemination in laryngopharyngeal squamous cell carcinoma. | 2007 | 17066224 |
| levothyroxine replacement therapy after thyroid surgery. | new entities, such as 'subclinical' over- and undersubstitution, are easily diagnosed after thyroid surgery due to improved testing methods, and the incidence of thyroidectomy with lifelong hormone substitution is increasing. thus, there is a need to review conventional replacement therapy after thyroid surgery. we investigated the adequacy of our thyroid hormone replacement therapy for three months after total-, subtotal-, and hemithyroidectomy using an upper reference limit of thyrotropin (tsh ... | 2006 | 17067083 |
| transrectal ultrasound in the staging of clinical t3a prostate cancer. | the clinical staging of t3a prostate cancer is usually based on digital rectal examination (dre). overstaging of clinical t3a prostate cancer is present in 13-27% of the cases presented and understaging is in the range of 30%. the value of transrectal ultrasound (trus) as a staging tool is not generally accepted. the purpose of this study is to determine whether trus can refine the local staging in unilateral clinical t3a (ct3a) prostate cancer. | 2007 | 17067773 |
| structure-guided mutational analysis of t4 rna ligase 1. | t4 rna ligase 1 (rnl1) is a trna repair enzyme that circumvents an rna-damaging host antiviral response. whereas the three-step reaction scheme of rnl1 is well established, the structural basis for catalysis has only recently been appreciated as mutational and crystallographic approaches have converged. here we performed a structure-guided alanine scan of nine conserved residues, including side chains that either contact the atp substrate via adenine (leu179, val230), the 2'-oh (glu159), or the ... | 2006 | 17068206 |
| dose-dependant hypothyroidism in mice induced by commercial trimethoprim-sulfamethoxazole rodent feed. | trimethoprim-sulfamethoxazole (tmp-smx) medication in the feed or water is commonly administered to immunocompro mised mice to prevent the occurrence of pneumocystis murina (formerly p. carinii) pneumonia. therapeutic doses of smx can cause decreased total and free thyroxine (t4) levels in dogs and thyroid hypertrophy and hyperplasia in mice, rats, and dogs. our primary objective was to determine whether smx at doses present in commercially available rodent tmp-smx feed would pro duce hypothyroi ... | 2006 | 17069024 |
| lessons to learn from eortc study 08981: a feasibility study of induction chemoradiotherapy followed by surgical resection for stage iiib non-small cell lung cancer. | the present eortc phase ii feasibility study in stage iiib (t4-n3) nsclc was conducted to investigate whether an induction regimen with concurrent chemoradiotherapy followed by surgery after restaging by re-mediastinoscopy and/or fluorodeoxyglucose-positron emission tomography (fdg-pet) was feasible in a multicenter setting. unfortunately, the study closed prematurely because of poor accrual. the combination of more stringent selection criteria, the incorrect prevailing view of ethical boards th ... | 2007 | 17069931 |
| multicomponent anthrax toxin display and delivery using bacteriophage t4. | we describe a multicomponent antigen display and delivery system using bacteriophage t4. two dispensable outer capsid proteins, hoc (highly antigenic outer capsid protein, 155 copies) and soc (small outer capsid protein, 810 copies), decorate phage t4 capsid. these proteins bind to the symmetrically localized capsid sites, which appear following prohead assembly and expansion. we hypothesized that multiple antigens fused to hoc can be displayed on the same capsid and such particles can elicit br ... | 2007 | 17069938 |
| total intravenous anesthesia with propofol and remifentanil is associated with a nearly twofold higher incidence in postanesthetic shivering than desflurane-fentanyl anesthesia. | postanesthetic shivering (pas) is a frequent side effect of general anesthesia. previous reports on the incidence of pas of propofol for the induction or maintenance of anesthesia have been controversial, but have not been studied in detail. the aim of the present study was to evaluate the incidence and severity of pas in total intravenous anesthesia (tiva) with propofol and remifentanil compared with an inhalative anesthesia. | 2006 | 17072268 |
| dual olfactory pathway in the honeybee, apis mellifera. | the antennal lobes (als) are the primary olfactory centers in the insect brain. in the al of the honeybee, olfactory glomeruli receive input via four antennal sensory tracts (t1-4). axons of projection neurons (pns) leave the al via several antenno-cerebral tracts (acts). to assign the input-output connectivity of all glomeruli, we investigated the spatial relationship of the antennal tracts and two prominent al output tracts (medial and lateral act) mainly formed by uniglomerular (u) pns using ... | 2006 | 17072827 |
| rational attempts to optimize non-natural nucleotides for selective incorporation opposite an abasic site. | translesion dna synthesis represents the ability of a dna polymerase to misinsert a nucleotide opposite a dna lesion. previous kinetic studies of the bacteriophage t4 dna polymerase using a series of non-natural nucleotides suggest that pi-electron density of the incoming nucleotide substantially contributes to the efficiency of incorporation opposite an abasic site, a nontemplating dna lesion. however, it is surprising that these nonhydrogen-bonding analogues can also be incorporated opposite n ... | 2006 | 17073450 |
| health-related quality-of-life study in patients with carcinoma of the thyroid after thyroxine withdrawal for whole body scanning. | the authors studied the change of health-related quality of life (hr-qol) in patients with differentiated thyroid carcinoma (dtc) with thyroxine (t4) withdrawal in preparation for whole body radioactive iodine scanning. | 2006 | 17075410 |
| value of computed tomography-based tumor volume as a predictor of outcomes in hypopharyngeal cancer after treatment with definitive radiotherapy. | to investigate the value of pretreatment computed tomography (ct) volumetric analysis for the prediction of treatment outcome in patients with hypopharyngeal cancer (hpc) treated by definitive radiotherapy (rt). | 2006 | 17075415 |
| [central congenital hypothyroidism due to graves' disease in the mother]. | two male twins were born at a gestational age of 30 weeks. five days after delivery, the mother was diagnosed with graves' disease. the thyroid function in the neonates was therefore evaluated, which led to the detection of central congenital hypothyroidism (central cht), even though the neonatal cht-screening had been reported to be normal. both boys were treated with thyroxine up to the age of nine months. it was then established that their development had been uneventful. maternal graves' dis ... | 2006 | 17076354 |
| the effect of oral consumption of perchlorate, alone and in combination with ethanol, on plasma thyroid hormone and brain catecholamine concentrations in the rat. | literature has reported a controversy concerning the effects of the environmental pollutant perchlorate on pertinent physiological systems. however, no research to date has evaluated the effect of concomitant consumption of perchlorate and an additional environmental contaminant on physiological systems. the present preliminary investigation served to assess the effects of oral consumption of perchlorate, alone and in combination with ethanol, on thyroid hormone and brain catecholamine concentra ... | 2006 | 17076684 |
| sodium/iodide symporter (nis) gene expression is the limiting step for the onset of thyroid function in the human fetus. | terminal differentiation of the human thyroid is characterized by the onset of follicle formation and thyroid hormone synthesis at 11 gestational weeks (gw). | 2007 | 17077129 |
| prognostic value of the sixth edition ajcc/uicc tnm classification for differentiated thyroid carcinoma with extrathyroid extension. | the prognostic value of the sixth edition ajcc/uicc tnm classification is currently unclear. | 2007 | 17077130 |
| monitoring thyroglobulin in a sensitive immunoassay has comparable sensitivity to recombinant human tsh-stimulated thyroglobulin in follow-up of thyroid cancer patients. | most thyroglobulin (tg) assays have a sensitivity of 0.5-1 ng/ml. a minority of patients with undetectable t4-suppressed tg levels have a recombinant human tsh (rhtsh)-stimulated tg above 2 ng/ml and identifiable residual disease. | 2007 | 17077133 |
| a brief exposure to moderate passive smoke increases metabolism and thyroid hormone secretion. | active smoking influences normal metabolic status and thyroid function. | 2007 | 17077134 |
| acanthamoeba isolates belonging to t1, t2, t3, t4 and t7 genotypes from environmental freshwater samples in the nile delta region, egypt. | the free-living amoebae of the genus acanthamoeba include non-pathogenic and pathogenic species and has been recently classified into 15 different genotypes, t1-t15. in this study, a survey was conducted in order to determine the presence and pathogenic potential of free-living amoebae of acanthamoeba genus in freshwater sources associated with human activities in the nile delta region, egypt. identification of acanthamoeba was based on the morphology of cyst and trophozoite forms and pcr amplif ... | 2006 | 17078918 |