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multiple olfactory receptor neurons and their axonal projections in the antennal lobe of the honeybee apis mellifera.the poreplate sensilla of honeybees are equipped with multiple olfactory receptor neurons (orns), which innervate glomeruli of the antennal lobe (al). we investigated the axonal projection pattern in glomeruli of the al (glomerular pattern), formed by the multiple orns of individual poreplate sensilla. we used the different glomerular patterns to draw conclusions about the equipment of poreplate sensilla with different orn types. orns of single poreplate sensilla were stained and analyzed by las ...200616566001
peritoneal cytology does not increase the prognostic information provided by tnm in gastric cancer.this study aimed at verifying whether peritoneal cytology could improve the prognostic information provided by tnm staging in gastric cancer patients.200616568221
thyroid hormone and thyrotropin regulate intracellular free calcium concentrations in human polymorphonuclear leukocytes: in vivo and in vitro studies.intracellular free calcium concentrations (ca++i) were studied in polymorphonuclear leukocytes (pmns) from 13 athyreotic patients who had been previously treated by total thyroidectomy and radioiodine therapy for differentiated thyroid carcinoma, and from age- and sex-matched euthyroid healthy controls. patients were studied twice, when hypothyroid (visit 1) and after restoration of euthyroidism by l-t4 tsh-suppressive therapy (visit 2). pmns from patients at visit 1 had significantly lower rest ...200616569353
effects of long-term treatment with resveratrol and subcutaneous and oral estradiol administration on the pituitary-thyroid-axis.the lack of estrogen during menopause is associated with various symptoms including osteoporosis, cardiovascular diseases, and menopausal symptoms. for many years, conventional hormone replacement therapy has been successfully used to treat these conditions. however, in light of recent studies that draw attention to potential hazards of conventional hrt, various attempts were undertaken to search for alternatives of classical hrt. phytoestrogens are supposed to ameliorate various discomforts ass ...200616570238
development of effective quantum mechanical/molecular mechanical (qm/mm) methods for complex biological processes.motivated by the long-term goal of understanding vectorial biological processes such as proton transport (pt) in biomolecular ion pumps, a number of developments were made to establish combined quantum mechanical/molecular mechanical (qm/mm) methods suitable for studying chemical reactions involving significant charge separation in the condensed phase. these developments were summarized and discussed with representative problems. specifically, free energy perturbation and boundary potential meth ...200616570942
the effect of visual biofeedback on the propulsion effectiveness of experienced wheelchair users.to determine the effect of visual feedback on the propulsion effectiveness of experienced manual wheelchair users.200616571390
methods to electrophoretically stretch dna: microcontractions, gels, and hybrid gel-microcontraction devices.the ability to controllably and continuously stretch large dna molecules in a microfluidic format is important for gene mapping technologies such as direct linear analysis (dla). we have recently shown that electric field gradients can be readily generated in a microfluidic device and the resulting field is purely elongational. we present a single molecule fluorescence microscopy analysis of t4 dna (169 kbp) stretching in the electric field gradients in a hyperbolic contraction microchannel. in ...200616572214
arm to leg coordination in elite butterfly swimmers.this study proposed the use of four time gaps to assess arm-to-leg coordination in the butterfly stroke at increasing race paces. fourteen elite male swimmers swam at four velocities corresponding to the appropriate paces for, respectively, the 400-m, 200-m, 100-m, and 50-m events. the different stroke phases of the arm and leg were identified by video analysis and then used to calculate four time gaps (t1: time gap between entry of the hands in the water and the high break-even point of the fir ...200616572376
the impact of hypotension due to the trigeminocardiac reflex on auditory function in vestibular schwannoma surgery.surgical manipulation of the fifth cranial nerve during its intra- or extracranial course may lead to bradycardia or even asystole as well as arterial hypotension, a phenomenon described as the trigeminocardiac reflex (tcr). the authors studied the impact of this reflex on postoperative auditory function in patients undergoing vestibular schwannoma (vs) surgery.200616572648
a role for replication repair in the genesis of templated mutations.replication repair mediates error-free bypass of dna damage in a series of steps that include regression of the replication fork, primer-terminus switching to use the other daughter strand as an undamaged template, primer extension, primer switching back to its cognate template with the primer terminus now having bypassed the damage, and fork rearrangement to a normal configuration. by both genetic and biochemical criteria, bacteriophage t4 catalyzes replication repair with two alternative sets ...200616574154
targeted thoracic epidural blood patch placed under electrical stimulation guidance (tsui test).this case report describes the use of electrical epidural stimulation (tsui test) to confirm accurate placement of a thoracic epidural catheter when administering an epidural blood patch for headache management in a patient suffering from spontaneous intracranial hypotension.200616575036
replicative fragmentation in t4 phage: inhibition by chloramphenicol. 196316578552
clinical efficacy and safety of transdermal methimazole in the treatment of feline hyperthyroidism.thirteen cats, newly diagnosed with hyperthyroidism, were treated with a transdermal formulation of methimazole at a dose of 5 mg (0.1 ml) (concentration of 50 mg/ml) applied to the internal ear pinna every 12 h for 28 d. baseline hematologic and biochemical values, along with serum thyroxine (t4) levels, were obtained on presentation (day 0). cats were evaluated at 14 d (d14) and 28 d (d28) following transdermal therapy. at each visit, a physical examination, a complete blood cell count, a seru ...200616579038
effects of deracoxib and aspirin on serum concentrations of thyroxine, 3,5,3'-triiodothyronine, free thyroxine, and thyroid-stimulating hormone in healthy dogs.to evaluate the effects of deracoxib and aspirin on serum concentrations of thyroxine (t4), 3,5,3'-triiodothyronine (t3), free thyroxine (ft4), and thyroid-stimulating hormone (tsh) in healthy dogs.200616579752
addison's disease presenting as male infertility.to present a case of primary male infertility with severe oligospermia and hyperpigmented skin as the main presenting clinical signs.200616580396
thyroid hormone receptor alpha1 directly controls transcription of the beta-catenin gene in intestinal epithelial cells.thyroid hormones, t3 and t4, are known regulators of intestine development. the best characterized example is the remodeling of the gastrointestinal tract during amphibian metamorphosis. thyroid hormones act via nuclear receptors, the trs, which are t3-dependent transcription factors. we previously showed that intestinal epithelial cell proliferation is controlled by thyroid hormones and the tralpha gene. to analyze the mechanisms responsible, we studied the expression of genes belonging to and/ ...200616581794
reflex regulation of airway sympathetic nerves in guinea-pigs.sympathetic nerves innervate the airways of most species but their reflex regulation has been essentially unstudied. here we demonstrate sympathetic nerve-mediated reflex relaxation of airway smooth muscle measured in situ in the guinea-pig trachea. retrograde tracing, immunohistochemistry and electrophysiological analysis identified a population of substance p-containing capsaicin-sensitive spinal afferent neurones in the upper thoracic (t1-t4) dorsal root ganglia (drg) that innervate the airwa ...200616581869
distance determination by giy-yig intron endonucleases: discrimination between repression and cleavage functions.giy-yig homing endonucleases are modular proteins, with conserved n-terminal catalytic domains connected by linkers to c-terminal dna-binding domains. i-tevi, the t4 phage giy-yig intron endonuclease, functions both in promoting td intron homing, and in acting as a transcriptional autorepressor. repression is achieved by binding to an operator, which is cleaved at 100-fold reduced efficiency relative to the intronless homing site. the linker includes a zinc finger, which functions in distance de ...200616582101
single-stage thoracolumbar vertebrectomy with circumferential reconstruction and arthrodesis: surgical technique and results in 15 patients.circumferential reconstruction and arthrodesis can be necessary after thoracolumbar vertebrectomy. the authors describe a technique for single-stage thoracolumbar vertebrectomy with circumferential reconstruction and arthrodesis. the surgical results using this technique are reviewed.200616582649
increased transglutaminase activity was associated with il-6 release in cultured human gingival fibroblasts exposed to dental cast alloys.molecular mechanisms underlying gingival and periodontal inflammation caused by dental alloys are still poorly understood. recently, it has been demonstrated that tissue transglutaminase can be involved in inflammatory cell response. the aim of this study was to evaluate effects of exposure to orthodontic materials on transglutaminase in cultured human gingival fibroblasts. the incubation with ni-ti heat-activated (t3) or ni-ti super-elastic (t4), and with ni-cr-co (t2) alloys produced respectiv ...200616583305
[ambivalent bacteriophages of different species active on escherichia coli k12 and salmonella sps. strains].a study was made of several bacteriophages (including phages u2 and lb related to t-even phages of escherichia coli) that grow both on e. coli k12 and on some salmonella strains. such phages were termed ambivalent. t-even ambivalent phages (u2 and lb) are rare and have a limited number of hosts among salmonella strains. u2 and lb are similar to canonical e. coli-specific t-even phages in morphological type and size of the phage particle and in reaction with specific anti-t4 serum. phages u2 and ...200616583699
hyperthyroidism and the kidney.hyperthyroidism and chronic renal failure (crf) are both common diseases of older cats. hyperthyroidism increases gfr by a variety of physiologic effects. chronic renal failure can suppress total t4 concentrations in cats with concurrent hyperthyroidism, and free t4 is not a useful distinguishing test. medical therapy (ie, methimazole) is recommended in cats with pre-existing crf. overt renal failure occurs in approximately 30% of cats treated for hyperthyroidism. it usually occurs within one mo ...200616584026
medical management of hyperthyroidism.radioiodine is considered the treatment of choice for hyperthyroidism, but in some situations, methimazole therapy is preferred, such as in cats with pre-existing renal insufficiency. methimazole blocks thyroid hormone synthesis, and controls hyperthyroidism in more than 90% of cats that tolerate the drug. unfavorable outcomes are usually due to side effects such as gastrointestinal (gi) upset, facial excoriation, thrombocytopenia, neutropenia, or liver enzyme elevations; warfarin-like coagulopa ...200616584027
a bioluminescence assay for thyrotropin receptor antibodies predicts serum thyroid hormone levels in patients with de novo graves' disease.tsh receptor antibodies (tbii) in graves' disease (gd) may be tsh receptor stimulating (tsab) and blocking (tbab) antibodies. in commercially available assays however, only total tbii titres can be measured, without discriminating between tsab and tbab.200616584516
[endonasal micro-endoscopic resection of sinonasal inverted papilloma].the goal of this study was to assess the potentials and limitations of endonasal micro-endoscopic surgery in the treatment of sinonasal inverted papilloma (ip) and to demonstrate long-term results.200616586283
properties of bacteriophages t2 and t4 with unusual inheritance. 195616589893
the difference between spontaneous and base-analogue induced mutations of phage t4. 195916590424
specific antibodies to thermally denatured deoxyribonucleic acid of phage t4. 196016590710
ambivalent rii mutants of phage t4. 196116590849
a frame-shift mutation involving the addition of two base pairs in the lysozyme gene of phage t4. 196616591406
chromosome structure in phage t4, iii. terminal redundancy and length determination. 196716591467
chloroplast trna gene contains a long intron in the d stem: nucleotide sequences of tobacco chloroplast genes for trna (ucc) and trna (ucu).the nucleotide sequences of tobacco chloroplast genes for trna(gly) (ucc) and trna(arg) (ucu) have been determined. the trna(gly) gene has a 691-base-pair intron located in the d stem while the trna(arg) gene does not have any intron. the trna(gly) and trna(arg) genes are encoded on the same strand and separated by a 169-base-pair spacer. the trna(gly) gene is transcribed as a 900-base precursor rna molecule. the trna(gly) and trna(arg) deduced from the dna sequences show 84% and 55% sequence ho ...198416593407
heat-labile alkaline phosphatase from antarctic bacteria: rapid 5' end-labeling of nucleic acids.a heat-labile alkaline phosphatase has been purified to near homogeneity from hk47, a bacterial strain isolated from antarctic seawater. the active form of the enzyme has a molecular weight of 68,000 and is uniquely monomeric. the optimal temperature for the enzymatic activity is 25 degrees c. complete and irreversible thermal inactivation of the enzyme occurs in 10 min at 55 degrees c. by using this heat-labile enzyme for dephosphorylation followed by a 10-min heat treatment, rapid end-labeling ...198416593525
measurement of free thyroxine concentration in horses by equilibrium dialysis.the purpose of the study reported here was to validate measurement of free thyroxine (ft4) concentration in equine serum by equilibrium dialysis (ft4d), and to compare values with ft4 concentration measured directly and with total t4 (tt4) concentration. the ft4d, ft4, and tt4 concentrations were measured over a range of values in euthyroid horses and horses made hypothyroid by administration of propylthiouracil (ptu). concentrations of ft4d (<1.8-83 pmol/l) were consistently higher than those o ...200616594596
tandem mass spectrometry of intact groel-substrate complexes reveals substrate-specific conformational changes in the trans ring.it has been suggested that the bacterial groel chaperonin accommodates only one substrate at any given time, due to conformational changes to both the cis and trans ring that are induced upon substrate binding. using electrospray ionization mass spectrometry, we show that indeed groel binds only one molecule of the model substrate rubisco. in contrast, the capsid protein of bacteriophage t4, a natural groel substrate, can occupy both rings simultaneously. as these substrates are of similar size, ...200616594706
bacteriophage replication modules.bacteriophages (prokaryotic viruses) are favourite model systems to study dna replication in prokaryotes, and provide examples for every theoretically possible replication mechanism. in addition, the elucidation of the intricate interplay of phage-encoded replication factors with 'host' factors has always advanced the understanding of dna replication in general. here we review bacteriophage replication based on the long-standing observation that in most known phage genomes the replication genes ...200616594962
phase ii study of neoadjuvant docetaxel/ vinorelbine followed by surgery and adjuvant doxorubicin/cyclophosphamide in women with stage ii/iii breast cancer.the purpose of this study was to evaluate the combination of docetaxel plus vinorelbine as neoadjuvant chemotherapy for stage ii/iii locally advanced breast cancer.200616595034
sequential reorganization of beta-sheet topology by insertion of a single strand.insertions, duplications, and deletions of sequence segments are thought to be major evolutionary mechanisms that increase the structural and functional diversity of proteins. alternative splicing, for example, is an intracellular editing mechanism that is thought to generate isoforms for 30%-50% of all human genes. whereas the inserted sequences usually display only minor structural rearrangements at the insertion site, recent observations indicate that they may also cause more dramatic structu ...200616597830
[effect of excessive iodine exposure on the serum tc and tg level in rats].to study effect of excessive iodine exposure on the serum tc and tg level in rate.200616598951
coexistence of peripheral primitive neuroectodermal tumor and tetralogy of fallot.we describe a little girl with tetralogy of fallot (tof) who was found to have a huge peripheral primitive neuroectodermal tumor (ppnet) when she developed progressive difficulty in standing and crawling at the age of 11 months. the tumor was located in the left paraspinal region (t4-t12), with intraspinal extension causing severe compression. nine days after surgical decompression with laminectomy, chemotherapy was initiated with alternative courses of vincristine, doxorubicin, cyclophosphamide ...200616599020
guanidinium derivatives bind preferentially and trigger long-distance conformational changes in an engineered t4 lysozyme.the binding of guanidinium ion has been shown to promote a large-scale translation of a tandemly duplicated helix in an engineered mutant of t4 lysozyme. the guanidinium ion acts as a surrogate for the guanidino group of an arginine side chain. here we determine whether methyl- and ethylguanidinium provide better mimics. the results show that addition of the hydrophobic moieties to the ligand enhances the binding affinity concomitant with reduction in ligand solubility. crystallographic analysis ...200616600969
a study on staging bone scans in newly diagnosed prostate cancer.this study aimed to evaluate the role of bone scan as a staging investigation in newly diagnosed untreated prostate cancers.200616601380
the role of an upstream promoter interaction in initiation of bacterial transcription.the bacterial rna polymerase (rnap) recognizes promoters through sequence-specific contacts of its promoter-specificity components (sigma) with two dna sequence motifs. contacts with the upstream ('-35') promoter motif are made by sigma domain 4 attached to the flap domain of the rnap beta subunit. bacteriophage t4 late promoters consist solely of an extended downstream ('-10') motif specifically recognized by the t4 gene 55 protein (gp55). low level basal transcription is sustained by gp55-rnap ...200616601684
the clinical impact of histopathologic response assessment by residual tumor cell quantification in esophageal squamous cell carcinomas.the objectives of this study were to investigate histomorphologic features as a response classification after neoadjuvant radiochemotherapy (rtx/ctx) and to correlate the results with clinical outcome parameters (e.g., postoperative morbidity and mortality, recurrence, and survival) in patients with locally advanced esophageal squamous cell carcinoma (escc).200616607651
improved quality of life after sympathetic block for upper limb hyperhidrosis.the aim of the study was to assess two disease-specific quality of life (qol) instruments after limited endoscopic thoracic sympathetic block (ts) at t4 for upper limb hyperhidrosis.200616607680
telomerase subunit immunoreactivity and recurrence in colorectal cancer.telomerase is expressed in human germ tissues and in the majority of primary human tumors. the catalytic subunit of telomerase, htert is one of the most important components of telomerase. in this study we attempted to show by means of immunohistochemistry the association between htert expression and recurrence in 128 colorectal cancer patients surgically treated in the university of tokyo hospital.200616608021
[a comparative study on the resistance of bacteriophage t4, phixm174d, and f2 to glutaraldehyde in laboratory].to identify the best indicative bacteriophage in disinfection tests through comparing the resistance of bacteriophage t4, phix174d, and f2 to glutaraldehyde.200616608092
actual practice vs guidelines in laboratory monitoring of older patients with primary hypothyroidism in primary care.clinical guidelines are produced in order to achieve an acceptable standard of care, especially for patients with common diseases in primary care. the treatment of primary hypothyroidism serves as an example of the content of clinical guidelines and actual practice. the aim of this study was to compare the follow-up of primary hypothyroidism by thyroid function tests, serum tsh and serum-free t4, in older patients managed in primary care, with recommendations in treatment guidelines and textbook ...200616608134
[maxillary sinus cancers: prognosis and quality of life: a retrospective study of 22 cases].maxillary sinus cancer is uncommon. we present a study of 22 cases of patients managed at the nantes university hospital for maxillary sinus cancer during the time period 1989-2002.200616609666
neurobehavioral effects and hormones profile among spray painters.a cross-sectional study was conducted in 25 spray painters and 35 control subjects to evaluate neurobehavioral function, and thyroid and reproductive hormones profile. this study indicated higher prevalence of psychological and neurological symptoms, and clinical findings among spray painters when compared with controls. levels of tsh were significantly (p<0.01) elevated in spray painters over the control group (3.04 +/- 1.53 vs 1.88 +/- 1.07 microiu/ml, mean +/- sd), respectively. two of the 25 ...200616610541
identifying illness parameters in fatiguing syndromes using classical projection methods.to examine the potential of multivariate projection methods in identifying common patterns of change in clinical and gene expression data that capture the illness state of subjects with unexplained fatigue and nonfatigued control participants.200616610951
treatment of head and neck dermatitis with ciclopiroxolamine cream--results of a double-blind, placebo-controlled study.in atopic dermatitis, microbial allergens may be pathogenetically significant. apart from staphylococcus aureus, these are primarily lipophilic malassezia yeasts. they are particularly involved in the pathogenesis of head and neck dermatitis (hnd), a special form of atopic dermatitis, which is often difficult to treat. fifty patients (21 men, 29 women) with moderate to severe hnd of at least 6 months' duration were included in a prospective double-blind study. all of them showed at least 10% inv ...200616612143
[preoperative and palliative embolization of renal cell carcinomas: follow-up of 49 patients].to evaluate the influence of preoperative and palliative embolization of renal cell carcinomas on survival, intra- and post-operative procedures, and symptom control for palliative and preoperative indications.200616612730
tsh and thyroid hormones concentrations in patients with hypothyroidism receiving replacement therapy with l-thyroxine alone or in combination with l-triiodothyronine.the aim of this study was to evaluate parameters of thyroid function in patients with primary hypothyroidism receiving either monotherapy with l-t4 or combination l-t4+l-t3. fifty-eight women with primary hypothyroidism receiving l-t4 were enrolled in the study. the patients were randomised into two groups: group 1 (n=42) patients continued monotherapy with l-t4, and group 2 (n=16) patients were switched to combined therapy with l-t4+l-t3 (25 microg l-t4 was replaced with 12.5 microg l-t3). the ...200516613812
[prognostic role of microvascularization in surgically treated lung cancer].the aim of our study was the determination of microvascularization and its prognostic significance in lung cancer patients.200616617384
zinc as an antiperoxidative agent following iodine-131 induced changes on the antioxidant system and on the morphology of red blood cells in rats.iodine-131 ((131)i) irradiation is the first line treatment for graves' disease and thyroid carcinoma. in such cases, (131)i gets accumulated in the thyroid, and is released in the form of radioiodinated triiodothyronine (t3) and tetraiodothronine (t4). various reports describe changes in the blood picture after radioiodine treatment. zinc, on the other hand, has been reported to maintain the integrity of red blood cells (rbc) under certain toxic conditions. the present study was conducted to ev ...200616617389
computational mutagenesis studies of protein structure-function correlations.topological scores, measures of sequence-structure compatibility, are calculated for all 1,881 single point mutants of the human immunodeficiency virus (hiv)-1 protease using a four-body statistical potential function based on delaunay tessellation of protein structure. comparison of the mutant topological score data with experimental data from alanine scan studies specifically on the dimer interface residues supports previous findings that 1) l97 and f99 contribute greatly to the gibbs energy o ...200616617425
horseshoe lung and facio-auriculo-vertebral sequence: a previously unreported association.we describe a case of horseshoe lung in an infant with facio-auriculo-vertebral (fav) sequence that included mild hemifacial microsomia, ear anomalies, a missing left rib, left hemivertebrae (t2-t4), and complex congenital heart disease. of the approximately 40 cases of horseshoe lung described since 1962, most are reported in association with scimitar syndrome, and only four reported cases were associated with left lung hypoplasia. none of these cases included malformations consistent with a di ...200616617456
conserved sequence motif dppy in region iv of the phage t4 dam dna-[n-adenine]-methyltransferase is important for s-adenosyl-l-methionine binding.comparison of the deduced amino acid sequences of dna-[n(6)-adenine]-methyltransferases has revealed several conserved regions. all of these enzymes contain a dppy-motif, or a variant of it. by site-directed mutagenesis of a cloned t4 dam gene, we have altered the first proline residue in this motif (located in conserved region iv of the t4 dam-mtase) to alanine or threonine. the mutant enzymic forms, p172a and p172t, were overproduced and purified. kinetic studies showed that compared to the wi ...199316617501
morphometric analysis of mandibular growth in skeletal class iii malocclusion.the craniofacial growth patterns of untreated individuals with skeletal class iii malocclusion have rarely been systemically investigated. this study used morphometric techniques to investigate the growth characteristics of the mandible in individuals with skeletal class iii malocclusion.200616618612
efficient rna 5'-adenylation by t4 dna ligase to facilitate practical applications.we describe a simple procedure for rna 5'-adenylation using t4 dna ligase. the 5'-monophosphorylated terminus of an rna substrate is annealed to a complementary dna strand that has a 3'-overhang of 10 nucleotides. then, t4 dna ligase and atp are used to synthesize 5'-adenylated rna (5'-apprna), which should find use in a variety of practical applications. in the absence of an acceptor nucleic acid strand, the two-step t4 dna ligase mechanism is successfully interrupted after the adenylation step ...200616618967
[comparison on resistance of bacteriophages to sodium dichloroisocyanurate in laboratory].to scan the most resistable bacteriophage as an indicator in disinfection tests, and to study the resistance of bacteriophage t4, phichi 174d, and f2 to the sodium dichloroisocyanurate (nadcc) in laboratory.200616620594
neoadjuvant chemotherapy for locally advanced carcinoma of the lower oesophagus and oesophago-gastric junction.to evaluate a single unit's experience with neoadjuvant chemotherapy for treating locally advanced non-metastatic initially resectable and unresectable oesophago-gastric cancer.200616621430
advantages and pitfalls of 18f-fluoro-2-deoxy-d-glucose positron emission tomography in detecting locally residual or recurrent nasopharyngeal carcinoma: comparison with magnetic resonance imaging.this prospective study was designed to elucidate the advantages and pitfalls of (18)f-fdg pet in detecting locally residual/recurrent nasopharyngeal carcinoma (npc) in comparison with mri.200616622711
population-based study of prognostic factors in stage ii colonic cancer.adjuvant chemotherapy in stage ii colorectal cancer may be considered for patients whose tumours have poor prognostic features. the aim of this study was to evaluate the prognostic significance of commonly reported clinical and pathological features of stage ii colonic cancer.200616622901
prostate cancer screening and detection in inner-city and underserved men.in the era of serum prostate-specific antigen (psa) screening, the incidence of prostate cancer has increased dramatically. simultaneously however, stage migration has occurred, and treatment outcomes have improved. inner-city men have lower screening rates and, thus, may be diagnosed with more advanced disease that it less likely to be successfully treated.200616623063
evaluation of the longitudinal contraction of the ventricle septum in patients undergoing off-pump coronary artery bypass graft surgery by strain rate imaging.strain rate (sr) imaging is an emerging technique for assessing myocardial systolic and diastolic functions. this technique can provide assessment in real time and color mapping; it also can detect ischemia at its earlier stages in comparison with visual estimation of wall motion with other techniques.200616623402
procalcitonin and conventional markers of inflammation in peritoneal dialysis patients and peritonitis.to determine the significance of a newly described marker of inflammation procalcitonin (pct), and to investigate its relationship to conventional markers of inflammation, such as c-reactive protein (crp), fibrinogen, and erythrocyte sedimentation rate (esr), in patients on peritoneal dialysis (pd) and with peritonitis.200616623432
transcription of a 'photosynthetic' t4-type phage during infection of a marine cyanobacterium.the transcription of s-pm2 phage following infection of synechococcus sp. wh7803, a marine cyanobacterium, was analysed by quantitative real-time pcr. unlike the distantly related coliphage t4, there were only two (early and late) instead of three (early, middle and late) classes of transcripts during the developmental cycle of the phage. this difference is consistent with the absence from the s-pm2 genome of t4-like middle mode promoter sequences and the transcription factors associated with th ...200616623740
subclinical thyroid disorders and cognitive performance among adolescents in the united states.thyroid hormone plays a crucial role in the growth and function of the central nervous system. the purpose of the study was to examine the relationships between the status of subclinical thyroid conditions and cognition among adolescents in the united states.200616623938
relationship between subclinical thyroid dysfunction and femoral neck bone mineral density in women.osteoporosis associated with thyroid dysfunction has been traditionally viewed as a secondary consequence of altered thyroid function, but there was recently a report about the direct effects of thyroid-stimulating hormone (tsh) on bone remodeling, which was mediated via the tsh receptor found on osteoblast and osteoclast precursor cells. endogenous subclinical thyroid dysfunction seems to be an appropriate model to examine the direct effect of tsh on bone metabolism while ruling out the direct ...200616624651
[effect of oral cordarone in reversing persistent atrial fibrillation].to observe the efficacy and safety of oral cordarone dir reversing persistent atrial fibrillation (af). methods; eighty-two symptomatic chronic af out-patients without history of acute diseases or severe hepatic/thyroid dysfunction were given oral cordarone at the loading dose of 200 mg thrice a day for 1-4 weeks followed by a twice-daily administration for another 1-4 weeks, with the maintenance dose of 200 or 100 mg once a day. the incidence of stroke and cardiac events and the mortality rate ...200616624772
synchronous primary carcinomas of the bladder and prostate.to determine the incidence of adenocarcinoma of the prostate for patients undergoing radical cystoprostatectomy for bladder cancer in taiwan.200616625287
a mode of action for induction of thyroid gland tumors by pyrethrins in the rat.prolonged treatment with high doses of pyrethrins results in thyroid gland tumors in the rat. to elucidate the mode of action for tumor formation, the effect of pyrethrins on rat thyroid gland, thyroid hormone levels and hepatic thyroxine udpglucuronosyltransferase activity was investigated. male sprague-dawley cd rats were fed diets containing 0 (control) and 8000 ppm pyrethrins and female rats diets containing 0, 100, 3000 and 8000 ppm pyrethrins for periods of 7, 14 and 42 days and for 42 day ...200616626768
staging of nasopharyngeal carcinoma investigated by magnetic resonance imaging.to investigate the american joint commission on cancer (ajcc) sixth edition staging system of nasopharyngeal carcinoma (npc) by magnetic resonance imaging (mri).200616626827
dose-response relationship of nasopharyngeal carcinoma above conventional tumoricidal level: a study by the hong kong nasopharyngeal carcinoma study group (hknpcsg).to define the dose-response relationship of nasopharyngeal carcinoma (npc) above the conventional tumoricidal dose level of 66 gy when the basic radiotherapy (rt) course was given by the 2d ho's technique.200616626829
placental restriction alters circulating thyroid hormone in the young lamb postnatally.intrauterine growth restriction (iugr) is associated with accelerated growth and increased adiposity in early life due to unknown mechanisms, which could include increased thyroid hormone (th) action. we hypothesized that placental restriction (pr) of fetal growth would increase circulating th concentrations and alter their response to fasting, and that these would relate to growth and body composition in the young lamb. pr reduced size at birth, increased fractional growth rates (fgrs) of soft ...200616627695
ntp toxicology and carcinogenesis studies of 3,3',4,4',5-pentachlorobiphenyl (pcb 126) (cas no. 57465-28-8) in female harlan sprague-dawley rats (gavage studies).dioxin toxic equivalency factor evaluation overview: polyhalogenated aromatic hydrocarbons such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (tcdd) have the ability to bind to and activate the ligand-activated transcription factor, the aryl hydrocarbon receptor (ahr). structurally related compounds that bind to the ahr and exhibit biological actions similar to tcdd are commonly referred to as "dioxin-like compounds" (dlcs). ambient human exposure to dlcs occurs through the ingestion of foods containin ...200616628245
managing thyroid cancer without thyroxine withdrawal.thyroxine (t4) withdrawal or recombinant tsh is used for the stimulation of thyroglobulin (tg), whole-body scanning (wbs) and iodine-131 treatment in patients with thyroid carcinoma. this study evaluated the t4 dose reduction protocol as an alternative for patients' preparation. fifty-one patients were submitted to total t4 withdrawal for wbs and tg measurement. t4 treatment was then resumed and maintained until tsh reached levels < 0.3 miu/l. the t4 dose was then decreased to 0.8 microg/kg/day ...200616628280
rhizosphere bacteria affected by transgenic potatoes with antibacterial activities compared with the effects of soil, wild-type potatoes, vegetation stage and pathogen exposure.a greenhouse experiment was performed to analyze a potential effect of genetically modified potatoes expressing antibacterial compounds (attacin/cecropin, t4 lysozyme) and their nearly isogenic, nontransformed parental wild types on rhizosphere bacterial communities. to compare plant transformation-related variations with commonly accepted impacts caused by altered environmental conditions, potatoes were cultivated under different environmental conditions, for example using contrasting soil type ...200616629752
recognition of pore-forming colicin y by its cognate immunity protein.construction of hybrid immunity genes between colicin u (cui) and y (cyi) immunity genes and site-directed mutagenesis of cyi were used to identify amino-acid residues of the colicin y immunity protein (cyi) involved in recognition of colicin y. these amino-acid residues were localized close to the cytoplasmic site of the cyi transmembrane helices t3 (s104, s107, f110, a112) and t4 (a159). mutations in cui, which converted cui sequence to cyi sequence in positions 104, 107, 110, 112 and 159, res ...200616630264
treatment of squamous cell anal canal carcinoma (scacc) with pulsed dose rate brachytherapy: a retrospective study.to evaluate the results of pulsed dose rate brachytherapy (pdr) in scacc.200616631268
interrelationship of hepatic function, thyroid activity and mood status in alcohol-dependent individuals.alcohol-induced changes in thyroid function may contribute to the development of mood disorders such as depression and anxiety that almost invariably coexist in alcohol-dependent individuals. the aim of the present study was to investigate the severity of liver dysfunction and thyroid activity in correlation with anxiety and depressive-like symptomatology before and after a detoxification period.200616634533
mechanism of presynaptic filament stabilization by the bacteriophage t4 uvsy recombination mediator protein.uvsy is the recombination mediator protein (rmp) of bacteriophage t4, which promotes homologous recombination by facilitating presynaptic filament assembly. the results of previous studies suggest that uvsy promotes the assembly of presynaptic filaments in part by stabilizing interactions between t4 uvsx recombinase and single-stranded dna (ssdna). to test this hypothesis, we studied the interactions of uvsx and uvsy with a fluorescein-derivatized oligonucleotide. this assay distinguishes betwee ...200616634631
phase i/ii study of preoperative oxaliplatin, fluorouracil, and external-beam radiation therapy in patients with locally advanced rectal cancer: cancer and leukemia group b 89901.the addition of oxaliplatin to fluorouracil in patients with advanced colorectal cancer improves survival. this phase i/ii study evaluated the addition of weekly oxaliplatin to preoperative continuous infusion fluorouracil (fu) and external-beam radiation therapy (rt) in patients with locally advanced rectal adenocarcinoma.200616636336
repeated pulmonary rehabilitation in severe and disabled copd patients.the optimal frequency of delivering a pulmonary rehabilitation program (pr) is not yet a well established issue. it is still unclear whether repeated pr at established intervals will result in effective maintenance or further improvement in the patient's health status.200616636528
[establishment of murine cell line transfected with human cd14 gene].this study was aimed to construct the cd14 eukaryotic expression vector, establish the transgeneic cd14 positive cell line in order to facilitate the establishment of a mouse model of antibody targeting therapy for human acute monocytic leukemia (aml-m(5)). total rna extracted from peripheral blood mononuclear cells was treated with rnaase-free dnaase, the human cd14 gene was cloned and sequenced through the rt-pcr and t-a clone techniques. eukaryotic expressional vector pcdna3.1(+)/cd14 was con ...200616638222
evaluation of ionized and total serum magnesium concentrations in hyperthyroid cats.hyperthyroidism can increase the renal excretion of magnesium and thus cause hypomagnesemia in various species. anaerobically collected blood samples from 15 hyperthyroid and 40 normal, healthy cats were analyzed with an ion-selective electrode analyzer and a serum biochemical analyzer. there was no significant difference in ionized or total serum magnesium concentration between the 2 groups, but there was a significant difference (p = 0.004) in the ratio of ionized to total serum magnesium conc ...200616639946
nasopharyngeal carcinoma in children: a single institution's experience.nasopharyngeal carcinoma is a very rare disease of children. between 1992 and 2005, 8 male and 2 female patients [ages ranging from 12 to 17 years,] were treated in our institution. the histopathologies were all undifferentiated type (who type iii). of the ten patients, one was t2, five were t3, and four were t4, respectively (tnm system of the american joint committee for cancer staging). eight patients had node metastases, 6/8 had bilateral and 4/8 had nodes larger than 6 cm. the main symptoms ...200516639999
evaluation of a two-generation reproduction toxicity study adding endpoints to detect endocrine disrupting activity using lindane.a two-generation reproduction toxicity study in rats adding extra endpoints to detect endocrine disrupting activity was conducted using lindane by dietary administration at 0, 10, 60, and 300 ppm, for investigation of its utility. the extra endpoints included anogenital distance (agd), nipple development, sexual maturation (vaginal opening and preputial separation), estrous cycle, spermatogenesis, sex organ weights, and blood hormone concentrations (thyroid and sex hormones). f1 offspring were e ...200516641539
evaluation of a two-generation reproduction toxicity study adding endpoints to detect endocrine disrupting activity using vinclozolin.a two-generation reproduction toxicity study in rats adding extra endpoints to detect endocrine disrupting activity was conducted using vinclozolin by dietary administration at 0, 40, 200, and 1000 ppm, for investigation of its utility. the extra endpoints included anogenital distance (agd), nipple development, sexual maturation (vaginal opening and preputial separation), estrous cycle, spermatogenesis, sex organ weights, and blood hormone concentrations (thyroid and sex hormones). hepatic drug- ...200516641540
stage-associated overexpression of the ubiquitin-like protein, isg15, in bladder cancer.bladder cancer is among the most prevalent malignancies, and is characterised by frequent tumour recurrences and localised inflammation, which may promote tissue invasion and metastasis. microarray analysis was used to compare gene expression in normal bladder urothelium with that in tumours at different stages of progression. the innate immune response gene, interferon-stimulated gene 15 kda (isg15, gip2), was highly expressed at all stages of bladder cancer as compared to normal urothelium. we ...200616641915
renal cell carcinoma local recurrences: impact of surgical treatment and concomitant metastasis on survival.to analyse the survival benefit of resecting local recurrence (lr) of renal cell carcinoma (rcc) in the presence and absence of concomitant metastasis.200616643473
cloning the genes and dna binding properties of high mobility group b1 (hmgb1) proteins from the human blood flukes schistosoma mansoni and schistosoma japonicum.the parasitic helminth schistosoma mansoni contains three hmgb proteins, hmgb1, hmgb2 and hmgb3, of primary amino acid sequences highly similar to vertebrate proteins. in this report we describe the characterization of the hmgb1 proteins and their genes from s. mansoni and schistosoma japonicum. the deduced amino acid sequences of hmgb1 proteins from both schistosome species are identical, and comprise 176 residues. the proteins contain the two evolutionarily highly conserved hmg-box domains, a ...200616644144
increased serum cxcl10 in graves' disease or autoimmune thyroiditis is not associated with hyper- or hypothyroidism per se, but is specifically sustained by the autoimmune, inflammatory process.serum cxcl10 (an interferon-gamma-inducible chemokine) levels (scxcl10) are increased in several autoimmune conditions, including graves' disease (gd) and autoimmune thyroiditis (at). longitudinal assessment of scxcl10 in autoimmune hypo- or hyperthyroidism has not yet been performed.200616645011
intraoperative coagulation evaluation of ischemia-reperfusion injury in small bowel transplantation: a way to explore.the success of intestinal transplantation is affected by the extreme susceptibility of the small bowel to ischemia-reperfusion (i/r) injury. platelet aggregation decreases after reperfusion in small intestinal ischemia and liver transplantation. thromboelastography (teg) is a coagulation test performed whole on blood. the aims of this study were to assess coagulation derangements during bowel transplantation to define appropriate modalities of intraoperative coagulation monitoring. a secondary e ...200616647482
intraoperative coagulation monitoring and small bowel transplantation: a way to explore.the existence of coagulation disorders during intestinal transplantation is getting more important for a correct anesthetic management. both a condition of hypocoagulation and hypercoagulation can happen during the intraoperative course. thromboelastography (teg), a test on whole blood coagulation, allows measurement of different phases of coagulation function. the aims of our study were to evaluate coagulation derangements during bowel transplantation using teg.200616647483
surgical treatment of scoliosis in larsen syndrome with bilateral hip dislocation.this is a report of a 12-year-old girl treated surgically for scoliosis associated with bilateral hip dislocation in larsen syndrome.200616648737
prevalence and persistence of certain serologic types of streptococcus pyogenes in metropolitan tokyo.m-typing was conducted for streptococcus pyogenes strains isolated within 1 week of admission from patients admitted to the tokyo metropolitan toshima hospital for scarlet fever in the 23-year period between 1956 and 1978. m12 was detected in the largest number of patients, followed by m6, m4, m3, and m1. t-typing was also conducted for streptococcus pyogenes strains isolated from healthy schoolchildren in three different parts of the 20-year period between 1977 and 1998. t12 was detected in the ...200616648943
[determination of p53 in infiltrative primary bladder tumors as a prognostic factor for understaging].to determine if p53 expression in patients with infiltrative bladder cancer is a prognostic factor on clinical staging and cancer specific survival.200616649517
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