| rapid clearance of serum amyloid a from high-density lipoproteins. | the serum amyloid a proteins (saa) occur in plasma in six polymorphic forms that are associated with the high-density lipoproteins (hdl). we studied two of the saa proteins, saa1 and saa4, which have the same amino- and carboxy-terminal residues but different solution properties and electrophoretic mobilities, to determine whether they are interconverted in plasma in vivo. they were radioiodinated in vitro, incorporated into hdl, and administered to cynomolgus monkeys. both remained associated w ... | 1984 | 6696928 |
| pulse wave velocity and morphological changes associated with early atherosclerosis progression in the aortas of cynomolgus monkeys. | to determine the time course of changes in arterial stiffness and corresponding morphology during atherosclerosis progression, we determined pulse wave velocity (pwv) in cynomolgus monkeys fed atherogenic (test) and control diets over an 18-month period. at 6-month intervals, thoracic and abdominal aortic pwvs were determined with a pressure transducer retracted down the aorta in 5 cm increments. iliac artery pwv was determined from the abdominal aortic pressure to a noninvasive femoral pulse. g ... | 1984 | 6697337 |
| age-related decline of lymphoid-tissue components in the oral mucosa of the lip, cheek and soft palate of macaca fascicularis. | in three mature monkeys (macaca fascicularis; 3.5 +/- 0.3 kg in weight), the labial, buccal and soft-palate mucosae were examined morphologically and stereologically. using fixation by perfusion, standardized methods of tissue preparation and morphometric analysis at the light-microscopic level, the gross dimensions (i.e., epithelial thickness, width of combined lamina propria/submucosa) and the volumetric composition of the oral mucosae were estimated and compared with those of young animals ex ... | 1984 | 6697380 |
| nerve fiber layer of the primate retina: morphometric analysis. | the organization of the retinal nerve fiber layer of the cynomolgus monkey was studied by electron microscopy. nerve fiber size spectra were obtained from measurements of every fiber in enlarged montages of selected bundles. variation in spectra among nasal, arcuate, and papillomacular bundles was examined, and variation of spectra of a given bundle as it crossed the retina was determined. among the three types of bundles, the papillomacular contained relatively more small fibers, nasal bundles ... | 1984 | 6698729 |
| greater splanchnic excitation of primate t1-t5 spinothalamic neurons. | effects of electrical stimulation of the left greater splanchnic nerve (spl) on t1-t5 spinothalamic (stt) neurons were determined. eighty-five stt neurons were studied in 36 anesthetized monkeys (macaca fascicularis). all neurons were excited by manipulation of their somatic receptive fields and by electrical stimulation of cardiopulmonary (cp) sympathetic afferent fibers. spl stimulation excited 63 (74%) stt neurons. there was an increasing percentage of cells with spl input at more caudal segm ... | 1984 | 6699679 |
| the relationship of the eye uptake of n-isopropyl-p-[123i]iodoamphetamine to melanin production. | eye uptake has been a potential concern with n-isopropyl-p-[123i]iodoamphetamine (i-123 imp) because it has been observed in certain animal species. we have investigated the cause of the eye uptake and its relationship to melanin synthesis. in a 1-yr-old cynomolgus monkey, high concentration of the tracer was seen in the eyes regardless of the type of anesthesia (pentobarbital or ketamine) or the oral administration of lugol's solution. the eye uptake at 24 hr after injection of i-123 imp was eq ... | 1984 | 6699722 |
| the effects of prenatal ethanol in cynomolgus monkeys. | ethanol was administered to pregnant cynomolgus monkeys (macaca fasicularis) from day 20 to 150 of gestation. the ethanol was delivered by intragastric intubation twice a day at 8 am and 5 pm. dosage was begun at a relatively low level, 2 g/kg/day and increased gradually to attain a final dosage of 4 or 5 g/kg/day. the offspring were allowed to be delivered naturally and remained with their mother until 23 days of age when they were sacrificed. maternal blood ethanol and acetaldehyde levels were ... | 1984 | 6701806 |
| paraquat-induced pulmonary fibrosis. role of the alveolitis in modulating the development of fibrosis. | paraquat, a widely used herbicide, can cause severe and often fatal pulmonary fibrosis in humans and in laboratory animals. although paraquat is known to be directly cytotoxic to lung parenchymal cells, the mechanism by which this leads to pulmonary fibrosis is not completely understood. in a model of paraquat-induced pulmonary fibrosis using the cynomolgus monkey, the administration of paraquat (10 mg/kg/wk subcutaneously for 2 consecutive wk) was followed by an alveolitis comprised of neutroph ... | 1984 | 6703475 |
| repair of the pigment epithelial barrier following photocoagulation. | mild argon laser burns produced in the retina of cynomolgus monkeys underwent differentiated retinal repair with frequent restoration of the pigment epithelial barrier. permeability of the restored barrier was tested by two tracers injected intravenously--horseradish peroxidase followed by electron microscopic evaluation and fluorescein sodium followed by fluorescence microscopic examination of freeze-dried tissue. tightness of the barrier was associated with regularly arranged pigment epithelia ... | 1984 | 6703956 |
| experimental retinal detachment. v. fluid movement through the retinal hole. | unilateral chronic rhegmatogenous retinal detachments were produced in eight cynomolgus monkeys. fellow eyes underwent total vitrectomy. aqueous-plasma and vitreous-plasma ratios of fluorescein isothiocyanate-dextran (70,000 molecular weight) after intravenous administration were less than 0.004 in detached and fellow eyes. intravitreal injection of fluorescein isothiocyanate-dextran in detached eyes passed into the subretinal space at a rate of 1.12 microl/min, where it was visibly sequestered ... | 1984 | 6703957 |
| callosal mechanism for the interhemispheric transfer of hand somatosensory information in the monkey. | the retrograde transport of horseradish peroxidase (hrp) was combined with extracellular microelectrode recording from single and multiple-neurones to study the anatomical and functional organization of the callosal connections of the hand sensory projection field in the parietal operculum of monkeys (macaca irus). in 3 animals anaesthetized with ketamine, a single injection of hrp (0.5 microliter) was delivered into the cortex forming the upper bank of the sylvian sulcus at a site where neurona ... | 1984 | 6704235 |
| an ultrastructural study of the neuronal changes in the cardiac ganglia of the monkey (macaca fascicularis) following unilateral vagotomy. | this study describes at the ultrastructural level the neuronal changes in the intracardiac ganglia of the monkey (macaca fascicularis) following unilateral vagotomy. one day after unilateral vagotomy, some intracardiac neurons showed an overall increase in electron density, with the dendrites darkening first. at three days after operation the dendrites appeared jet black and their intracytoplasmic organelles were hardly distinguishable except for some pale mitochondria. the perikarya of the affe ... | 1984 | 6706840 |
| morphometric studies on the structural development of the lung in macaca fascicularis during fetal and postnatal life. | the structural development of the normal monkey lung (macaca fascicularis) from 61 days of gestation to 14 days postnatal age has been described using quantitative morphometric techniques. the lung of the adult monkey has also been studied. the airway and arterial branching pattern has been traced using serial sections. the alveolar number and size have been estimated and the structure of the arteries after postmortem arterial injection has been assessed. comparison of lung morphology in monkey ... | 1984 | 6706842 |
| is neurotensin in the brain involved in thermoregulation of the monkey? | cannulae for intracerebroventricular (icv) infusion were implanted stereotaxically in monkeys (macaca fascicularis) maintained post-operatively in a primate restraint chair. during each experiment, a series of physiological measures was recorded simultaneously on a polygraph which included colonic temperature, vasomotor tone, heart rate, respiratory rate, and basal metabolism as reflected by o2 uptake. the icv infusion in a volume of 0.5 ml of neurotensin (nt) in doses ranging from 3-150 microgr ... | 1984 | 6709509 |
| long-term consequences of exposure to ozone. i. lung collagen content. | lung collagen content of rats and monkeys (macaca fascicularis) exposed to ozone for 1 to 13 weeks and for 1 year, respectively, was quantified by measurement of 4-hydroxyproline in hydrolysates of whole lungs. in addition, ratios of type i to type iii collagen in the lungs of the same monkeys were also evaluated by cyanogen bromide peptide mapping techniques. we observed elevated levels of collagen in lungs of both species of animals exposed to ozone. we conclude that elevations in collagen syn ... | 1984 | 6710477 |
| apoprotein b quantification in rhesus and cynomolgus monkey atherosclerotic lesions. | the concept that much of the cholesterol deposition in atherosclerotic plaque development is provided by ingress of blood-derived apo b-rich lipoproteins into the arterial intima is given support by the study of arterial apo b accumulation. to compare the arterial wall level of immunoreactive apo b during the progression of diet-induced atherosclerosis in two widely used animal models of atherosclerosis, rhesus and cynomolgus monkeys were fed an atherogenic diet for 4, 8, and 12 months and their ... | 1984 | 6712774 |
| effect of penicillin on the renal tubular secretion of methotrexate in the monkey. | the effect of penicillin on the renal tubular secretion of methotrexate (mtx) in rhesus and cynomolgus monkeys was studied in vivo and in vitro. in stop-flow experiments in ketamine-anesthetized monkeys, the ratios of urine/plasma mtx concentration to urine/plasma inulin concentration of proximal tubular samples were about 2-fold greater than the base-line free-flow values of 3.3 to 4.8, indicating net proximal tubular secretion. mtx secretion was inhibited by penicillin, which lowered the base- ... | 1984 | 6713392 |
| the cynomolgus monkey as a model for orbital research. i. normal anatomy. | significant differences in anatomy preclude the use of the more common small research animals in orbital studies. one must look to the anthropoid apes to find a species comparable to man in both bony skeleton and soft tissue contents. while the orbit of the cynomolgus monkey is remarkably similar to that of man, differences still do exist. in this monkey, the ethmoid, frontal and sphenoid sinuses are absent, and the os planum of the ethmoid is represented in only a minority of younger animals. a ... | 1984 | 6713953 |
| the cynomolgus monkey as a model for orbital research. ii. anatomic effects of lateral orbitotomy. | in order to assess the anatomic consequences of lateral orbitotomy in a disease-free muscle cone, a technique of microsurgical exposure of the ciliary ganglion in the cynomolgus monkey was formulated. animals were sacrificed at 2 and 6 months following surgery, and microscopic sections of the whole orbit prepared and compared to sections taken from the non-operated contralateral orbits. findings at two months were: periorbital thickening and hypercellularity along with osteoneogenesis at sites r ... | 1984 | 6713954 |
| the cynomolgus monkey as a model for orbital research. iii. effects on ocular physiology of lateral orbitotomy and isolation of the ciliary ganglion. | five cynomolgus monkeys underwent unilateral lateral orbitotomy and isolation but not removal of the ciliary ganglion. orbitotomized eyes were compared with untouched contralateral eyes with respect to intraocular pressure, aqueous humor formation rate, pupillary diameter and light reflex, corneal reflex, entry of intravenously administered fluorescein into the anterior chamber, anterior chamber volume, pharmacologically (pilocarpine, carbachol, echothiophate) induced accommodation, electroretin ... | 1984 | 6713955 |
| passive antibody therapy of lassa fever in cynomolgus monkeys: importance of neutralizing antibody and lassa virus strain. | lassa virus-infected cynomolgus monkeys were passively immunized with immune plasma of primate or human origin to gain insight into criteria for plasma selection and administration to human lassa fever patients. protective efficacy was correlated with neutralizing antibody concentrations, expressed as a log10 neutralization index (lni). convalescent lassa-immune monkey plasma was titrated for protective efficacy in monkeys by intravenous inoculation with dilutions of plasma on the day of subcuta ... | 1984 | 6715049 |
| the commissural connections of the monkey hippocampal formation. | the commissural connections of the hippocampal formation have been analyzed in the monkey (macaca fascicularis) using both anterograde and retrograde labeling techniques. we have observed a number of striking differences between the organization of the commissural projections in the monkey and that observed in the rodent brain. in particular, only the rostral (or uncal) part of ammon's horn (or hippocampus proper) and the associated part of the dentate gyrus have been found to be connected by co ... | 1984 | 6715582 |
| enhanced treatment of lassa fever by immune plasma combined with ribavirin in cynomolgus monkeys. | lassa virus-infected cynomolgus monkeys were treated with lassa virus-immune monkey serum containing a high concentration of neutralizing antibody, the antiviral drug ribavirin, or a combination of ribavirin plus immune serum at various times after infection. when treatment was initiated early (day 0 or 4), either ribavirin (30 mg/kg of body weight per day) or immune serum alone protected monkeys. however, when the initial treatment was delayed until day 7, only four of eight ribavirin-treated a ... | 1984 | 6715898 |
| supplementary motor area of the monkey's cerebral cortex: short- and long-term deficits after unilateral ablation and the effects of subsequent callosal section. | the short-term and long-term behavioral effects of unilateral lesions of the supplementary motor area (sma) were studied in five monkeys (macaca fascicularis ssp). a monkey with a unilateral lesion of the premotor area (pm) served as a control. in all animals, general behavior was unaffected by the lesions. for a few weeks postoperatively, all monkeys showed a clumsiness of forelimb movements, bilaterally, which involved both the distal and proximal muscles. two sma-lesioned monkeys (but not the ... | 1984 | 6716131 |
| relationship of brain blood flow and oxygen consumption to perfusion flow rate during profoundly hypothermic cardiopulmonary bypass. an experimental study. | a study was made of the relation of brain blood flow and oxygen consumption to changes in perfusion flow rate during cardiopulmonary bypass at 20 degrees c in nine cynomolgus monkeys. four perfusion flow rates varying from 0.25 to 1.75 l x min-1 x m-2 were randomly instituted, each for a 10 minute period. at the end of each period, brain arteriovenous oxygen content difference was measured and 15 mu radioactive microspheres were injected into the arterial perfusion line. the brain was then remov ... | 1984 | 6717045 |
| spectral sensitivity of single cones in the retina of macaca fascicularis. | colour vision depends on the wavelength-dependent absorptions of three different photolabile pigments each located in a particular type of retinal cone. the spectral absorption of primate cones has been examined by microspectrophotometry, but this method gives information only at wavelengths where the absorption is relatively strong. here we have analysed the absorption of two of the cones over a wider range of wavelengths by recording their electrical responses to monochromatic light. the obser ... | 1984 | 6717604 |
| grating visual evoked potentials in the evaluation of laser bioeffects: twenty nanosecond foveal ruby exposures. | a series of experiments was performed to determine the parameters necessary to produce immediate measurable changes in the visual system of nonhuman primates after exposure of the fovea to laser radiation. the parameters investigated were stimulus spatial frequency (1.6 and 2.8 c/deg), size of the visual field stimulated (30 and 3.6 degrees), retinal diameter of the laser exposure (50 and 500 micron), and total intraocular energy. steady-state visual evoked potentials (vep's) were recorded from ... | 1984 | 6720865 |
| experimental retinal detachment. vii. intravenous horseradish peroxidase diffusion across the blood-retinal barrier. | intravenous horseradish peroxidase (hrp) was administered to cynomolgus monkeys to study chorioretinal diffusion in eyes with retinal detachment. in control eyes, hrp was contained within the choriocapillaris and did not penetrate beyond bruch's membrane. in addition, hrp was confined within blood vessels of the sensory retina. in detached eyes, hrp diffused out of the choriocapillaris and through the intercellular spaces of the retinal pigment epithelium (rpe), where it was blocked by zonulae o ... | 1984 | 6721769 |
| changes in the connective tissue proteins, glycosaminoglycans and calcium in the arteries of the cynomolgus monkey during atherosclerotic induction and regression. | the chemical composition of the aorta, carotid, coronary and cerebral arteries of the cynomolgus monkey was determined during the induction and 'regression' of atherosclerosis. the feeding of a 2% cholesterol and 10% butter diet for 6 months resulted in extensive and severe atherosclerosis involving the aorta, carotid and coronary arteries. the involvement of these vessels was reflected by increases in arterial weight and chemical content of cholesterol, collagen, elastin, glycosaminoglycans (ga ... | 1984 | 6721905 |
| testosterone can initiate spermatogenesis in an immature nonhuman primate, macaca fascicularis. | four 1-yr-old, i.e. immature, monkeys (m. fascicularis) were treated with testosterone. for the first 21 weeks, they received testosterone capsules sc; thereafter for the remainder of 1 yr, they received weekly injections of 125 mg testosterone enanthate. four similarly aged monkeys served as untreated controls. the testosterone enanthate injections produced a peak level of 345 +/- 70 nmol/liter (mean +/- sd) after 24 h and the levels were 187 +/- 39 nmol/liter 7 days later. the overall mean lev ... | 1984 | 6723580 |
| prevention of monkey sperm penetration of zona-free hamster ova by sperm antibody obtained from vasectomized cynomolgus monkeys. | incubation of antisperm sera from vasectomized cynomolgus monkeys (macaca fascicularis) with monkey sperm caused a fourfold reduction of sperm attachment to and penetration of zona-free golden hamster ova. the attachment of sperm to hamster ova was reduced from 64% to 11%, and the penetration of ova was reduced from 20% to 5%. sperm antibodies block sperm attachment to the vitelline membrane, thus preventing ovum penetration. this blockage may be one of the reasons for low fertility rates observ ... | 1984 | 6724005 |
| physicochemical and histological changes in the arterial wall of nonhuman primates during progression and regression of atherosclerosis. | to identify the temporal changes occurring during progression and regression of atherosclerosis in nonhuman primates, we have studied the physicochemical and histological characteristics of arterial wall lesions during a 30-mo progression period of diet-induced hypercholesterolemia and during a 12-mo period of regression. three groups of cynomolgous monkeys (macaca fascicularis) were studied. control groups were fed a basal chow diet for 18, 24, and 30 mo and were compared with progression group ... | 1984 | 6725553 |
| sizes, laminar and topographic origins of cortical projections to the major divisions of the red nucleus in the monkey. | the retrograde transport of horseradish peroxidase was used to study the topographic and laminar origins of the cortical projections to the parvocellular and the magnocellular divisions of the red nucleus in macaca mulatta and macaca fascicularis. approximately 90% of the corticorubral projection is directed to the parvocellular division of the nucleus. corticoparvocellular (crp) neurons are pyramidally shaped, are smaller in size than corticospinal neurons, and are more numerous. they are found ... | 1984 | 6725640 |
| relationships between leydig cell morphometry and plasma testosterone during postnatal development of the monkey, macaca fascicularis. | in neonates (0 to 3-4 months), the testis contained a mean number of 4.6 x 10(6) leydig cells representing 4.2 % of its volume; leydig cell cytoplasm contained 10.2 % of ser. in infants (up to 45 months), leydig cells regressed but their number increased; their volume density did not change. leydig cell cytoplasmic volume (454 microns3 ), which was about 2.5-fold less than in neonates (1 119 microns3 ) or adults (1 170 microns3 ), contained only 8.7% of ser. during meiosis stage (38-52 months). ... | 1984 | 6729240 |
| a survey of parasitic lesions in wild-caught, laboratory-maintained primates: (rhesus, cynomolgus, and baboon). | the lesions associated with parasitic infestation in 1156 wild-caught, laboratory-maintained nonhuman primates (macaca fascicularis, macaca mulatta, and papio spp) are described. the two most common parasites seen were lung mites (pneumonyssus spp) and nodular worms (oesophagostomum spp). in addition, in cynomolgus monkeys (macaca fascicularis) only, nochtia nochti was a frequent pathogen. the etiology of mineralized fibrotic nodules in the mesentery of cynomolgus monkeys was thought to be infec ... | 1984 | 6730203 |
| [callosal connections of the somatosensory area in the primate: anatomical and electrophysiological studies]. | in order to study the callosal connections of the hand sensory field of the second somatosensory area of the monkey, experiments were carried out by combining the method of retrograde neuronal tracing with microelectrode recording. in six monkeys, macaca irus, single or multiple (5-8) injections of horseradish peroxidase (hrp) were performed into the cortex of the parietal operculum of one side. neurones retrogradely labelled with hrp (callosal neurones) were found in the post-central gyrus and ... | 1984 | 6732953 |
| augmented responses to vasoconstrictor stimuli in hypercholesterolemic and atherosclerotic monkeys. | we examined effects of hypercholesterolemia and atherosclerosis on vasoconstrictor responses to norepinephrine and serotonin. responses were compared in normal, atherosclerotic, and hypercholesterolemic but non-atherosclerotic cynomolgus monkeys. the hindlimb was perfused at constant flow so that changes in perfusion pressure indicated changes in vascular resistance. we measured the pressure gradient from the iliac to the dorsal pedal artery so that responses of the large artery segment could be ... | 1984 | 6733866 |
| an ultrastructural study of the non-neuronal cells in the cardiac ganglia of the monkey (macaca fascicularis) following unilateral vagotomy. | non-neuronal cells in the intracardiac ganglia of the monkey (macaca fascicularis) showed rapid responses to neuronal damage following unilateral vagotomy. most of the satellite cells appeared normal at one day after operation. however, from three to seven days after operation they were transformed into phagocytic cells, thereby engulfing the transneuronally affected dendrites of the neurons. by seven days after operation, most of the affected dendrites from the neuronal soma were engulfed by th ... | 1984 | 6735904 |
| light and electron microscopic features of the structure and innervation of the gastro-oesophageal junction of the monkey (macaca fascicularis). | this study describes the light and electron microscopical features of the gastrooesophageal junction of the monkey (macaca fascicularis). in longitudinal histological sections, the circular muscle layer at the junction is greatly thickened. this thickening is further demonstrated in a reconstructed model of the whole circular muscle coat and is therefore referred to as a 'sphincter'. quantitative ultrastructural studies on the circular muscle at the gastro-oesophageal junction or 'sphincter' sho ... | 1984 | 6735909 |
| periaqueductal gray neuronal activity associated with laryngeal emg and vocalization in the awake monkey. | extracellular recordings were made from 73 periaqueductal gray (pag) neurons in an awake, vocalizing monkey (macaca fascicularis). about 50% of the neurons were inactive and only began discharging prior to laryngeal emg activity and vocalization; they reached their peak firing rate near the onset of vocalization and then became inactive again. spike-triggered averaging of laryngeal emg from the pag unit discharge revealed in most cases an increase in laryngeal emg immediately following the unit ... | 1984 | 6738919 |
| sporozoite-induced plasmodium cynomolgi infections in captive born macaca fascicularis. | capability of captive born cynomolgus monkeys to substitute for rhesus in the plasmodium cynomolgi radical curative antimalarial drug development model was examined. eighteen monkeys divided into 3 groups were given standard or high doses of sporozoites intravenously. one group of 4 received 0.8 - 1.6 x 10(6) and a second group of 8 received 0.3 - 1.0 x 10(7) sporozoites. the third group of 6 was splenectomized and then received 3.0 - 4.0 x 10(6). the 2 groups of intact monkeys developed a persi ... | 1984 | 6740373 |
| small doses of human chorionic gonadotropin prevent estradiol-induced luteolysis. | the manner in which exogenous 17 beta-estradiol (e2) induces premature luteolysis in primates is unclear. in an effort to determine whether exogenous luteotropic hormone inhibits e2-induced luteolysis, e2 capsules were implanted subcutaneously in 11 cynomolgus macaques during the early luteal phase; six animals received injections of human chorionic gonadotropin (hcg; 7.5, 10, or 15 iu/day) for 10 days, and the remaining monkeys received saline. blood was collected once daily for measurement of ... | 1984 | 6742190 |
| oxytocin in the corpus luteum of the cynomolgus monkey (macaca fascicularis). | to determine if oxytocin (ot) is present in cynomolgus monkey corpus luteum, ot was measured by a specific and sensitive ria in 13 corpora lutea, ovarian venous plasma on the ipsilateral side and peripheral venous plasma at different stages of the luteal phase. serial dilution of acetic acid extract of the corpus luteum showed parallelism with standard ot in the ria. total content of ot in corpus luteum was 1.9 +/- 0.5 ng (mean +/- sem) with a content of 0.4-0.8 ng in early luteal phase, 1.0-6.2 ... | 1984 | 6745170 |
| simian varicella infection in the african green monkey (cercopithecus aethiops). | a severe and highly fatal disease occurred in african green monkeys (cercopithecus aethiops). the disease was marked by an extensive maculo-vesicular rash. in fatal cases, multifocal necrosis and hemorrhage were found characteristically in many organs and tissues. new cases of the disease occurred over a 39-day period. nine of 49 exposed african green monkeys were affected and five of the nine died. four cynomolgus (macaca fascicularis) and 31 stumptailed monkeys (macaca arctoides) which were ex ... | 1984 | 6748606 |
| an animal model of trachoma ii. the importance of repeated reinfection. | an animal model of chronic cicatrizing trachoma has been produced by repeated ocular inoculation with chlamydia trachomatis serotype e, a genitally transmitted strain. we have now produced a chronic follicular conjunctivitis on cynomolgus monkeys by repeated inoculation with c. trachomatis serotype a, which has been isolated from an area of endemic trachoma. this disease was similar in all respects to that which followed infection with the serotype e strain. cynomolgus monkeys inoculated with a ... | 1982 | 6749750 |
| effects of gestation on glucose tolerance and plasma insulin in cynomolgus monkeys (macaca fascicularis). | gestational alterations in carbohydrate metabolism in a group of cynomolgus monkeys were characterized by a decrease in fasting plasma glucose and by an increase in peak plasma insulin response subsequent to a glucose challenge. these changes are prominent as early as the first trimester of pregnancy. glucose clearance rates and fasting plasma insulin did not show significant changes during gestation or post partum. peak plasma insulin remained elevated in lactating animals studied 4 to 10 weeks ... | 1982 | 6753587 |
| scaling and root planing in shallow pockets. | the present study was undertaken to enable histological assessment of attachment level alterations following repeated scaling and root planing in periodontal sites with "normal" sulcus/pocket depth. two monkeys (macaca cynomolgus) were used. during a period of 6 months, scaling was carried out once every 2 weeks at the buccal surfaces of premolars and molars on the right side of the jaws. the contralateral teeth served as untreated controls. six months after the completion of treatment (1 year a ... | 1982 | 6754766 |
| [characteristics of echo-19 virus strain rad/40 causing an experimental lesion of the vascular coat of the eye (uveitis) in cynomolgus monkeys]. | four strains of echo-19 virus were isolated from a child with respiratory disease complicated with uveitis. a freshly isolated rad/40 strain of echo-19 virus was found to produce a severe disease of the vascular coat of the eye (uveitis) in javan cercopithecus monkeys inoculated directly into the anterior chamber of the eye. experimental uveitis is characterized by marked changes in the shape of the pupil, the lack of the pupil reaction to light, development of synechias, changes in the color of ... | 1982 | 6760552 |
| effects of pyridoxine, phytate and invert sugar on plaque composition and caries activity in the monkey (macaca fascicularis). | | 1980 | 6765919 |
| long-term vasectomy: effects on the occurrence and extent of atherosclerosis in rhesus monkeys. | we demonstrated previously that atherosclerosis develops more extensively in vasectomized cynomolgus macaques fed an atherogenic diet and speculated that the immunologic response to sperm antigens may have exacerbated the atherosclerosis. we report here that rhesus monkeys vasectomized for 9-14 yr and fed monkey chow (devoid of cholesterol and low in fat) rather than an atherogenic diet also had more extensive and severe atherosclerosis than did control animals of the same age. the extent of at ... | 1980 | 6765957 |
| neurons with complex visual properties in the superior colliculus of the macaque monkey. | single neurons were recorded from the superficial layers of the superior colliculus of immobilized monkeys (macaca mulatta and macaca irus). two main functional types of neurons were found. the neurons of the first type (type i neurons) responded well to simple stationary and moving stimuli such as spots, bars or slits of light. the latency of their response was 41 +/- 6 ms. they were not directionally selective and responded to a large range of velocities. the neurons of the second type (type i ... | 1980 | 6766110 |
| aggregate anaphylaxis in the monkey: haematological and histological findings. | haematological and histological studies were made following challenge in 8 monkeys (macaca irus) sensitized with ovalbumin. haemagglutinating, but no reaginic antibodies to ovalbumin were demonstrated before challenge. both platelet and leucocyte counts decreased markedly (-80 and -89%, respectively) within 5 min after challenge. no evidence of haemoconcentration was found. plasma fibrinogen decreased (-74%), indicating activation of the coagulation system. histological examination revealed plat ... | 1980 | 6766121 |
| failure of acute intravascular volume expansion to alter plasma vasopressin in the nonhuman primate, macaca fascicularis. | experiments were carried out in the anesthetized monkey to determine the influence of acute hypervolemia on plasma vasopressin (adh) concentration. the administration of an isotonic-isooncotic high molecular weight dextran infusion in two steps, each in an amount equal to 15% of the estimated blood volume, produced substantial elevations of left ventricular end diastolic pressure (17.1 cm h2o); however, no consistent change in mean plasma adh concentration or mean arterial pressure occurred. the ... | 1980 | 6766388 |
| experimental subarachnoid hemorrhage in the cynomolgus monkey: evaluation of treatment with hypertension, volume expansion, and ventilation. | we evaluated the treatment regime of dopamine-induced hypertension in association with volume expansion and ventilatory support in an experimental subarachnoid hemorrhage (sah) model using the cynomolgus monkey. regional cerebral blood flow, vessel caliber, intracranial pressure, and other pertinent physiological parameters were monitored throughout each study. we report the results for nine animals receiving treatment after an induced sah and compare them with results obtained in a group of fiv ... | 1980 | 6766538 |
| preparation of a defined immune complex for use in c1q binding assays. | soluble immune complexes of human beta 2 microglobulin with its igg antibodies from macaca irus antisera have been tested for suitability as a reference preparation for immune complex assays in human disease. the defined complex described is stable on storage, behaves reproducibly in a c1q solid phase binding assay and fulfills the criteria required for an international reference standard. | 1980 | 6766976 |
| responses to experimental subarachnoid hemorrhage in the spontaneously breathing primate. | the pathophysiological responses to experimental subarachnoid hemorrhage (sah) were investigated in 20 spontaneously breathing cynomolgus monkeys. four different volumes of fresh autogenous blood were used: 1.0, 1.33, 1.67, and 2.0 cc/kg. five other animals had injection of 1.67 cc/kg of mock cerebrospinal fluid. cerebral blood flow (cbf) was measured using the xenon-133 clearance technique. respiratory rate and tidal volume were monitored by way of a vertek pneumotach. the reduction of cbf afte ... | 1980 | 6767001 |
| nonlinear elimination and cholerteic effect of valproic acid in the monkey. | five adult cynomolgus monkeys (macaca fascicularis) were each given doses of 15 and 150 mg/kg of sodium valproate on separate occasions through indwelling arterial or venous catheters. timed samples of blood (0-1440 min) and urine were collected for measurement of free and conjugated valproic acid (vpa). in all animals a brief distribution (alpha) phase, complete by 10 to 15 min, was followed by a biphasic decline in concentration of the drug. the times required for the concentration of vpa in b ... | 1980 | 6767022 |
| microspectrophotometric demonstration of four classes of photoreceptor in an old world primate, macaca fascicularis. | 1. microspectrophotometric measurements reveal four classes of photoreceptor in the retina of the cynomolgus monkey, macaca fascicularis, which is known to possess colour vision similar to that of a normal human trichromat. 2. although the eyes were removed in bright illumination, the densities of pigment were comparable to those we have measured in dark-adapted rhesus retinae. 3. the mean wave-lengths of peak sensitivity (lambda max) for the four classes of photoreceptor were 415, 500, 535 and ... | 1980 | 6767023 |
| chorioretinal vascular anastomoses resulting from photocoagulation in cynomolgus monkeys. | we studied the effects of intense argon laser photocoagulation in cynomolgus monkeys to determine whether or not anastomosis between the choroidal circulation and the major retinal arterioles could be produced. chorioretinal vascular anastomosis occurred in nine of 19 sites in which photocoagulation was intense enough to occlude a major retinal arteriole and create disruption between the choroidal and retinal vasculatures. anastomosis was seen by fluorescein angiography during the healing phase ... | 1980 | 6767212 |
| immunologic responses of cynomolgus monkeys after repeated inhalation exposures to enzymes and enzyme--detergent mixtures. | | 1980 | 6767298 |
| "minified" goldmann applanating prism for tonometry in monkeys and humans. | the tip diameter of the standard goldmann applanating prism was reduced from 7.0 mm to 4.0 or 4.5 mm, but the endpoint of intraocular pressure measurement-applanation of a circle of cornea having a diameter of 3.06 mm-was not changed. the "minified" tonometers exhibited standard mechanical calibration characteristics in three standard configurations. the 4.5-mm tonometer was calibrated for cynomolgus monkey eyes in vivo by open and closed stopcock manometry. by open stopcock manometry, between p ... | 1980 | 6767468 |
| initial renal responses of nonhuman primate to immersion and intravascular volume expansion. | experiments were performed in anesthetized macaca fascicularis monkeys to determine if the initial renal responses of these animals to head-out vertical water immersion and isoncotic, isotonic volume expansion are similar, especially with regard to the onset of any changes in solute or water excretion. significant increases in urine flow, sodium excretion, and osmolar clearance occurred after 10 min of immersion but not until 30 min after volume expansion. potassium excretion increased during im ... | 1980 | 6767667 |
| experimental degeneration of motor and sensory cortical terminals in the cuneate nucleus of the monkey (macaca fascicularis). | a total of nine monkeys (macaca fascicularis) of both sexes was used for the present study. eight monkeys were used for either motor or sensory cortical lesions, and were allowed to survive for 1--7 days post-operatively. no degenerating nerve terminals were observed 1 day following either motor or sensory cortical lesions. after a motor cortical lesion, most degenerating terminals were seen on the third and only a few on the fifth day. following a sensory cortical lesion, most degenerating term ... | 1980 | 6767675 |
| blood-brain barrier transport and cerebral utilization of dopa in living monkeys. | [18f]fluoro-dopa, dl-3,4-dihydroxy-5-[18f]fluorophenylalanine, a tracer for dopa, was injected intravenously into cynomolgus monkeys anesthetized with enflurane, and the appearance of 18f in the head and the disappearance of 18f from the blood were each measured continuously for 10 min with simple gamma-ray detectors. a three-compartment explanatory model was used to derive fractional rate constants for the forward flux of l-dopa into the endothelium of the brain capillaries from the blood (1.54 ... | 1980 | 6769344 |
| metabolism by cells in culture of low-density lipoproteins of abnormal composition from non-human primates with diet-induced hypercholesterolemia. | diet-induced hypercholesterolemia in non-human primates results in the production of a low-density lipoprotein (ldl) of abnormal size and composition. this ldl from hypercholesterolemic monkeys has been shown to be more atherogenic than the same amount of ldl from normocholesterolemic animals. previous studies have demonstrated that hypercholesterolemic ldl is approximately twice as effective as normal ldl in stimulating cholesterol accumulation and esterification in arterial smooth muscle cells ... | 1980 | 6769492 |
| bruxism and trauma from occlusion. an experimental model in macaca monkeys. | the present study describes an experimental approach for inducing bruxism and trauma from occlusion in animals. gold occlusal cap splints overlaying the maxillary premolar and molar teeth were inserted in eight macaca irus monkeys. the cap splints were designed to raise the vertical dimension of occlusion by 3--4 mm and were adjusted to a balanced occlusion with the mandible in an unstrained retruded position. the splint on the right side (test side) was given a tight occlusion with the opposing ... | 1980 | 6769975 |
| influence of ascorbic acid and erythorbic acid on drug metabolism in the cynomolgus monkey. | | 1980 | 6769978 |
| subcortical afferents to the hippocampal formation in the monkey. | the distribution of neurons in the basal telencephalon, the diencephalon, and the brainstem that project to the hippocampal formation has been analyzed in mature cynomolgus monkeys (macaca fascicularis) by the injection of horseradish peroxidase into different rostro-caudal levels of the hippocampal formation. after injections which involve ammon's horn, the dentate gyrus, and the subicular complex, retrogradely labeled neurons are found in the following regions: in the amygdala (specifically in ... | 1980 | 6769979 |
| artery stenosis inhibits regression of diet-induced atherosclerosis. | reduction of blood pressure and serum cholesterol levels is associated with reduced risk for the development of arteriosclerotic disease. experimental studies indicate that reduced cholesterol levels result in arrest or regression of established diet-induced arterial lesions, but the effects of blood pressure reduction on such lesions are not clear. in order to investigate the effects of blood pressure on the regression of established lesions, we induced aortic intimal disease in cynomolgus monk ... | 1980 | 6770479 |
| carbon monoxide absorption through the oral and nasal mucosae of cynomolgus monkeys. | previous studies have shown that blood levels of carbon monoxide increase during cigarette smoking. it has generally been assumed that increases in blood levels of carbon monoxide could be interpreted as evidence that deep lung penetration of cigarette smoke had occurred. this study was designed to examine whether increased blood levels of carbon monoxide could result from absorption in the nasal and oral cavities. the nasal and oral cavities of cynomolgus monkeys were exposed, independently of ... | 1980 | 6770764 |
| arterial platelet accumulation in experimental hypercholesterolemia. | accumulation of arterial platelets was calculated from 51cr radioactivity in the intima-inner media of flushed, perfuse-fixed aortas and branch vessels of cynomolgus monkeys 48 hours after labeling of the blood platelets. in normo-cholesterolemic controls the radioactivity per square centimeter of tissue was consistently higher in aortic branching sites (circumostial aorta) than in the remainder of the aorta. in monkeys given 10 and 100 days of hypercholesterolemic diet radioactivity rose in cir ... | 1980 | 6770878 |
| distribution and changes in strength of hand preference of cynomolgus monkeys. | monkeys were observed for hand preference during simple reaching for food. the position of the animal relative to the food had only a slight influence upon the strength of hand preference. with repeated reaching, the strength of preference for the preferred hand tended to increase. the hand preferred on the first reach was predictive of that preferred over the entire series of 600 reaches in a significant proportion of individuals. this was not true of the animals presumed to be youngest and sug ... | 1980 | 6770961 |
| progesterone production by luteal cells isolated from cynomolgus monkeys: effects of gonadotropin and prolactin during acute incubation and cell culture. | corpus luteum function in cynomolgus monkeys (macaca fascicularis) during the menstrual cycle and immediately following parturition was evaluated through in vitro studies on progesterone production by dispersed luteal cells in the presence and absence of human chorionic gonadotropin (hcg) or human prolactin (hprl). luteal cells isolated between days 17-20 of the menstrual cycle secreted progesterone (p) during short-term incubation (21.6 +/- 1.2 ngp/ml/5 x 10(4) cells/3 hr, x +/- s.e., n = 7) an ... | 1980 | 6771895 |
| pharmacologic induction of luteolysis in cynomolgus monkeys (macaca fascicularis). | earlier studies reported from this laboratory demonstrated the luteolytic effect of a 5-day sequential regimen of 3 days of estrogen overlapped with 3 days of pgf2 alpha administered during the midluteal phase to cynomolgus monkeys. in this study, a different regimen, containing estrogen, lower doses of pgf2 alpha, and methylergonovine maleate (mem), was used. individual components of this modified sequential regimen were not effective as luteolytic agents. when 3 days of estrogen (40 micrograms ... | 1980 | 6772031 |
| glutathione s-transferase activity towards benz[a]anthracene 5,6-oxide in the liver, kidney and lung of cynomolgus monkeys. | | 1980 | 6772192 |
| use of captive-bred monkeys for vaccine production. | cynomolgus monkeys (macaca fasicularis) were bred in captivity for the production and control of inactivated poliomyelitis vaccine. compared to imported wild-caught animals the captive-bred monkeys contracted fewer virus infections, as evidenced by results of serological examination, and yielded remarkably clean cell cultures. these cultures could be grown in series and appear very suitable for the production of viral vaccines. | 1980 | 6772513 |
| the fine structure of the intermediolateral nucleus of the spinal cord of the monkey (macaca fascicularis). | an electron microscopical study of the intermediolateral nucleus of the monkey has shown that the neurons could be classified into at least three main types. the perikarya and proximal dendrite of types i and ii neurons were almost completely covered with astrocytic processes. both these types of neurons were characterized by prominent profiles of rough endoplasmic reticulum arranged in parallel stacks in type i and in small aggregates in type ii. the golgi apparatus was well developed in both t ... | 1980 | 6772621 |
| immunochemical identification and determination of proline-rich proteins in salivary secretions, enamel pellicle, and glandular tissue specimens. | acidic proline-rich proteins were localized histologically by means of the indirect immunoperoxidase technique in the acinar cells of parotid and submandibular gland sections of both man and macaca fascicularis. these proteins were also identified as constituents of the long term in vivo-formed acquired pellicle on human tooth surfaces employing the same immunoperoxidase technique. immunological quantitation of proline-rich proteins in whole and parotid saliva of 42 subjects indicates the presen ... | 1980 | 6772700 |
| squamous cell carcinoma with metastasis in a cynomolgus monkey (macaca fascicularis). | a squamous cell carcinoma of the vulva with metastases to the inguinal lymph nodes and lung occurred in a female cynomolgus monkey (maccaca fascicularis). the primary tumor was a pedunculated mass at the mucocutaneous junction of the left labium anterior to the clitoris. | 1980 | 6772874 |
| the effect on approximal drift of altering the horizontal component of biting force in adult monkeys (macaca irus). | | 1980 | 6773512 |
| heart and lung transplantation: autotransplantation and allotransplantation in primates with extended survival. | combined heart and lung transplantation was performed in rhesus or cynomolgus monkeys in order to confirm the ability of primates to withstand complete cardiopulmonary denervation, to develop a satisfactory operative method, and to obtain survival of allotransplant recipients using cyclosporin-a immune suppression. twenty-seven monkeys weighing 2.6 to 10.1 kg received either autotransplants or allotransplants by two different operative techniques. seventeen animals were operated upon with hypoth ... | 1980 | 6774178 |
| monkey pepsinogens and pepsins. monkey pepsinogens and pepsins. v. purification, characterization, and amino-terminal sequence determination of crab-eating monkey pepsinogens and pepsins. | pepsinogens were purified from the gastric mucosa of the crab-eating monkey, macaca fascicularis. eight pepsinogens were shown to be present disc-electrophoretically and they were termed pepsinogens i-a, i-b, iii-1-a, iii-1-b, iii-2-a, iii-2-b, iii-3, and c, based on the nomenclature used for japanese monkey pepsinogens. the molecular weights were 43,000 for pepsinogens i-a and i-b, 40,000 for pepsinogens iii-1-a, iii-1-b, iii-2-a, iii-2-b, and iii-3, and 38,000 for pepsinogen c, as determined b ... | 1980 | 6774974 |
| [immunohistochemical individualization of adenohypophyseal thyrotropic cells in the monkey macaca irus, using a human anti-beta-tsh antibody]. | using the indirect immunofluorescence technique and an antiserum against the specific beta subunit of human tsh, selective immunocytochemical staining was localized in a cell population of the pars distalis of the monkey macaca irus. these thyrotropic cells, which were positive to aldehyde fuchsin, alcian blue, and pas, were localized on the one hand in the ventro-medial zone of the pars distalis, especially alongside the large vessels of this region, and on the other in the zona tuberalis, i. e ... | 1980 | 6775838 |
| inhibition of progesterone secretion during the luteal phase by two luteinizing hormone-releasing hormone agonists in macaca fascicularis. | the administration of 200 microgram of the potent luteinizing hormone-releasing hormone (lhrh) agonist [d-leu6,des-gly-nh2(10)]lhrh ethylamide on day 6 following the plasma estradiol peak to 11 female monkeys (macaca fascicularis) during two consecutive menstrual cycles decreased plasma progesterone levels by 40.0% +/- 3.9% as compared with previous control cycles. the plasma estradiol profile and the cycle length were not affected significantly by the treatment. similar results were obtained wi ... | 1980 | 6778718 |
| vasospasm and cerebral blood flow after subarachnoid hemorrhage. | in a cynomolgus monkey model, the effect of subarachnoid hemorrhage on vessel calibre and cerebral blood flow was studied. arterial calibres were measured angiographically and cerebral blood flow was measured with 133xenon intra-arterial clearance techniques. only a poor correlation between large artery calibre and cerebral blood flow was found, indicating that cerebrovascular resistance changes at the microvascular level play a major role in the acute reduction of cerebral blood flow after suba ... | 1980 | 6778882 |
| a fatal case of hepatocystosis in an imported monkey (macaca fascicularis). | | 1980 | 6783777 |
| virologic control of monkeys used for the production of poliomyelitis virus vaccine. | wild-caught or captive-bred cynomolgus monkeys (macaca fascicularis) used at the national institute of public health for the production of inactivated poliomyelitis virus vaccine are extensively controlled for the presence of antiviral antibodies in their sera. with relatively simple methods of segregation and hygienic measures it seems possible to keep the animals free of infections with certain viruses including herpesvirus simiae and foamy viruses, which is of obvious importance for public he ... | 1981 | 6785124 |
| scrub typhus antibody in cynomolgus monkeys (macaca fascicularis) in malaysia. | using an indirect immunofluorescence technique, sera from 113 cynomolgus monkeys (macaca fascicularis), trapped in peninsular malaysia, were screened for the presence of antibody to six prototype strains of rickettsia tsutsugamushi combined into three polyvalent groupings: i--karp, ta716, and ta763; ii--gilliam; and iii--ta678 and th1817. fifteen percent (17/113) of the monkeys had antibody titers greater than or equal to 1:50 to one or more of the antigenic groups. although a titer greater than ... | 1981 | 6790836 |
| possible synthesis of pregnancy-'specific' beta-1-glycoprotein (sp1) and placenta-'specific' tissue proteins (pp10,pp12) by human and cynomolgus monkey leukocytes. | using an enzyme-bridge immunoperoxidase (pap) technique, it was revealed that pregnancy- and/or placenta-specific proteins, sp1, pp10 and pp12 were localized in human and cynomolgus monkey (macaca fascicularis) polymorphonuclear neutrophils, and pp10, in mononuclear phagocytes. there was no difference in staining results, irrespective of whether the specimens were from human or monkey males, or pregnant or nonpregnant females. the results suggest that sp1, pp10 and pp12 may be synthesized by pol ... | 1981 | 6794297 |
| ultrastructural changes after intracisternal injection of 6-hydroxydopamine in the intermediolateral nucleus of the monkey (macaca fascicularis). | the ultrastructural changes following a single intracisternal injection of 6-ohda were studied in the intermediolateral nucleus of the monkey spinal cord. post-operative survival periods ranged from 20 hours to 14 days. at all stages, only boutons containing clear, round vesicles (r-boutons) and those containing dense-cored vesicles (dcv-boutons) underwent degeneration. boutons containing flattened vesicles (f-boutons) appeared to be unaffected. changes were seen even at 20 hours after injection ... | 1981 | 6799475 |
| complement components c3, c4, and bf in six nonhuman primate species. | the extent of cross reactivity between antisera to human complement proteins [the third (c3) and fourth (c4) components and factor b (bf)] and these proteins in the sera of six species of nonhuman primates was examined. strong cross reactivity was found with these antisera and the specific complement proteins from rhesus monkeys, stumptailed macaques, cynomolgus macaques, patas monkeys, african green monkeys, and squirrel monkeys. although molecular differences were apparent as indicated by diff ... | 1982 | 6804713 |
| transplantation of enzyme-treated teeth in the monkey macaca fascicularis. | homologous tooth transplants evoke immunogenic rejection against antigens within donor periodontal ligaments cells and ground substance. eight maxillary incisors of 6 juvenile animals were extracted, crowns and pulps removed by gutta percha; the roots were incubated serially in enzyme solutions and glutaraldehyde at 37 degrees c for 5 h to destroy cells, glycoproteins and proteoglycans. seven control teeth from the same 6 animals were incubated in saline at 37 degrees c for 15 min. all teeth wer ... | 1982 | 6805450 |
| hemodynamic and metabolic effects of chronic carbon monoxide exposure in cynomolgus monkeys (macaca fascicularis). | cardio-respiratory data were obtained on four adult female cynomolgus monkeys, intermittently exposed to co for eight months and compared with data obtained from the same animals after five weeks of recovery. due to co exposure, the arteriovenous oxygen concentration difference and oxygen consumption decreased and blood oxygen affinity increased. however, there was no significant change in cardiac output and mixed venous po2. the cynomolgus monkeys adapted to chronic co exposure by reducing thei ... | 1981 | 6806477 |
| pituitary and thyroid function in male cynomolgus monkeys. | in four male cynomolgus monkeys, serum thyroxine was 6.2 +/- 0.9 micrograms/dl, and triiodothyronine was 207 +/- 12 ng/dl (mean +/- se). kinetic studies using 131i-thyroxine and 125i-triiodothyronine showed that the disappearance of both hormones was non-linear and best fit a biexponential equation. the metabolic clearance rates and production rates for thyroxine were 21.5 +/- 0.6 ml/kg/day and 1.34 +/- 0.23 micrograms/kg/day, respectively, and t1/2(beta) = 29.6 +/- 2.0 hours. for triiodothyroni ... | 1981 | 6806535 |
| the morphology and connections of the posterior hypothalamus in the cynomolgus monkey (macaca fascicularis). i. cytoarchitectonic organization. | the cytoarchitectonic organization of the posterior hypothalamus of the cynomolgus monkey (macaca fascicularis) was analyzed in nissl, golgi, acetylcholinesterase, and reduced silver preparations. the region consists of a number of cell masses that differ considerably in their discreteness and in the homogeneity of their neuronal populations. the nuclei identified include: the medial mamillary nucleus (in which at least three distinct subdivisions can be recognized--a pars medialis, a pars later ... | 1982 | 6808030 |
| the morphology and connections of the posterior hypothalamus in the cynomolgus monkey (macaca fascicularis). ii. efferent connections. | the efferent connections of the posterior hypothalamus have been analyzed autoradiographically in a series of eight cynomolgus monkey (macaca fascicularis) brains with injections of 3h-amino acids in different regions of the mamillary complex and the surrounding areas. the medial mamillary nucleus was found to project through the mamillothalamic tract to the ipsilateral anteroventral, anteromedial, and interanteromedial nuclei, and by way of the mamillotegmental tract principally to the deep teg ... | 1982 | 6808031 |
| hepatic microsomal enzyme induction by aroclors 1248 and 1254 in cynomolgus monkeys. | aroclors 1248 (2 mg/kg body weight) and 1254 (5 mg/kg body weight) produced a 3-methylcholanthrene type of mixed-function oxidase induction, in the livers of adult female cynomolgus monkeys after 69-122 days of dosing, when the animals were moribund. both aroclor 1248 and 1254 produced a mixed pattern of induction in mouse liver 66 hr after ip treatment with 1000 mg/kg body weight including changes characteristic of 3-methylcholanthrene-type induction. however the same dose of aroclor 1016 did n ... | 1982 | 6809545 |
| follicle dominance and ovarian asymmetry after luteectomy in rhesus monkeys. | previous work demonstrated that asymmetrical ovarian activity accompanies morphological asymmetry during the ovarian cycle in rhesus and cynomolgus macaques. this study was designed to determine whether functional ovarian asymmetry could be used to detect the upcoming dominant follicle (df) even before it was grossly visible. revealing a latent df in this manner would permit a better estimate of the time when dominance of the follicle selected to ovulate is attained. to accomplish this, rhesus m ... | 1982 | 6812434 |
| effect of polychlorinated biphenyls and polychlorinated quaterphenyls in cynomolgus monkey (macaca fascicularis). | female cynomolgus monkeys (macaca fascicularis) with p-kc-400, y-pcb, py-pcb or polychlorinated quaterphenyls (pcq) received a daily dose of 5 mg for 20 weeks, and some monkeys received a daily dose of 10 mg of y-pcb or 0.5 mg of pcq. the chemical compositions of the polychlorobiphenyls (pcb) used for the oral administration were as follows: p-kc-400, pcb from which polychlorodibenzofurans (pcdf) have been removed from kanecklor 400, largely contains tri- and tetrachlorobiphenyls and no pcdf. wh ... | 1982 | 6814017 |
| [menstrual cycle lengths and the estimated time of ovulation in the cynomolgus monkey (macaca fascicularis)]. | establishing of an efficient system for the judgement of an optimal mating time is an important prerequisite for the successful development of a large scale breeding of macaques as laboratory animals. in general, an optimal mating time has been judged on the basis of individual records of menstruation. the length of the previous menstrual cycle has usually been used for the prediction of the next cycle length. in the present study, the lengths of 240 menstrual cycles of 60 cynomolgus monkeys of ... | 1982 | 6814931 |