| basal and evoked levels of bioassayable growth hormone are altered by hindlimb unloading. | bioassayable growth hormone (bgh) in rats is released in large quantities from the pituitary in response to the activation of large, proprioceptive afferent fibers from fast and mixed fiber-type hindlimb musculature. we hypothesized that hindlimb unloading (hu) of adult male rats would 1) reduce the basal levels of plasma bgh, and 2) abolish stimulus-induced bgh release. rats were exposed to hu for 1, 4, or 8 wk. plasma and pituitaries were collected under isoflurane anesthesia for hormone analy ... | 2006 | 16339349 |
| effect of pcb 126 on hepatic metabolism of thyroxine and perturbations in the hypothalamic-pituitary-thyroid axis in the rat. | the objective of this research was to examine the time- and dose- dependent disturbances in the hypothalamic-pituitary-thyroid (hpt) axis of adult male rats administered a potent coplanar (non-ortho) pcb, 3,3',4,4',5-pentachlorobiphenyl (pcb 126). adult male sprague-dawley rats were administered a single oral bolus dose of 0, 7.5, 75, or 275 microg pcb 126/kg bw dissolved in corn oil. the rats were sacrificed periodically over 22 days. the 7.5-microg/kg dose induced hepatic ethoxyresorufin-o-dee ... | 2006 | 16339789 |
| evidence for differential expression of notch receptors and their ligands in melanocytic nevi and cutaneous malignant melanoma. | the notch signaling has been implicated in the regulation of self-renewal of adult stem cells and differentiation of precursors along a specific cell lineage, in normal embryonic development and organogenesis. there is also evidence that signaling through notch receptors regulate cell proliferation and cell survival in several types of cancer, with opposing results depending on tissue context. no data are available in the literature concerning modulation of the expression of notch receptors, and ... | 2006 | 16341148 |
| recombination of the gfp gene to the bfp gene using a man-made site-selective dna cutter. | by using the recently developed man-made dna cutter [a combination of ce(iv)/edta and two dna additives], green fluorescent protein (gfp) was converted to closely related blue fluorescent protein (bfp). the phosphodiester linkages at t196-a200 in the sense strand of gfp were hydrolyzed by the cutter, and the a1-t196 fragment in the product was selectively connected with the downstream fragment (c197-a720) of bfp by t4 dna ligase. this recombination changed three codons in the gfp gene (tgc at 19 ... | 2006 | 16341899 |
| conformational changes of yeast plasma membrane h(+)-atpase during activation by glucose: role of threonine-912 in the carboxy-terminal tail. | yeast pma1 h(+)-atpase, which belongs to the p-type family of cation-transporting atpases, is activated up to 10-fold by growth on glucose, and indirect evidence has linked the activation to ser/thr phosphorylation within the c-terminal tail. we have now used limited trypsinolysis to map glucose-induced conformational changes throughout the 100 kda atpase. in the wild-type enzyme, trypsin cleaves first at lys-28 and arg-73 in the extended n-terminal segment (sites t1 and t2); subsequent cleavage ... | 2005 | 16342953 |
| thyroid dysfunction and serum lipids: a community-based study. | it is uncertain whether subclinical hypothyroidism (sch) is associated with hypercholesterolaemia, particularly in subjects with sch and serum tsh < or = 10 mu/l. design, | 2005 | 16343102 |
| the course of mental health after miscarriage and induced abortion: a longitudinal, five-year follow-up study. | miscarriage and induced abortion are life events that can potentially cause mental distress. the objective of this study was to determine whether there are differences in the patterns of normalization of mental health scores after these two pregnancy termination events. | 2005 | 16343341 |
| treatment outcome of nasal and paranasal sinus carcinoma. | most authors recommend aggressive management for sinonasal carcinoma treatment. in an attempt to determine the optimal treatment, we assessed the treatment results of our patients with nasal cavity and paranasal sinus carcinoma. | 2005 | 16343397 |
| interrenal and thyroid development in red drum (sciaenops ocellatus): effects of nursery environment on larval growth and cortisol concentration during settlement. | red drum settle into shallow seagrass meadows during the larval stage. day-night cycles in these habitats result in marked diel temperature and dissolved oxygen (do) cycles, and it is possible that extreme fluctuations influence endocrine development and growth of larvae. here, we described red drum interrenal and thyroid ontogeny and determine responses to environmental stimuli with special emphasis on settlement to explore possible role of hormones as mediator of directive environmental factor ... | 2006 | 16343495 |
| silicates as nonspecific adsorbents of bacteriophage: a model for purification of water from viruses. | amorphous silicates having small particles with a large surface area were found to have high nonspecific adsorption capacity. investigations with escherichia coli t4 bacteriophage have shown adsorption capacity of up to 99.9% on different tested silicates. optimal conditions for the adsorption of t4 bacteriophage on various commercially available silicates were determined. a continuous-flow adsorption of t4 bacteriophage on silicates appears to be a model system for the removal of viruses from p ... | 1980 | 16345491 |
| interaction of escherichia coli b and b/4 and bacteriophage t4d with berea sandstone rock in relation to enhanced oil recovery. | much research and development is needed to recover oil reserves presently unattainable, and microbially enhanced oil recovery is a technology that may be used for this purpose. to address the problem of bacterial contamination in an oil field injection well region, we connected each end of a teflon-sleeved berea sandstone rock to a flask containing nutrient medium. by inoculating one flask with escherichia coli b, we could observe bacterial growth in the uninoculated flask resulting from the tra ... | 1984 | 16346492 |
| clinical performance and biocompatibility of novel hyaluronan-based heparin-bonded extracorporeal circuits. | we tested documented in vitro and ex vivo advantages of novel hyaluronan based heparin bonded extracorporeal circuits in a prospective randomized study. during the period from june until september 2005, 40 patients undergoing reoperation for coronary artery bypass grafting were allocated into two equal groups (n = 20): group 1 was treated with hyaluronan-based heparin-bonded circuits and group 2 was treated with uncoated control circuits. complete blood count, fibrinogen, albumin, c3a, interleuk ... | 2005 | 16350383 |
| the influence of human growth hormone (gh) and thyroxine (t4) on the differentiation of adipose tissue in the fetus. | late term fetuses from genetically obese dams have slightly larger fat cells, greater adipose tissue lipoprotein lipase (lpl) activities, elevated levels of thyroid hormones, and depressed growth hormone (gh) levels when compared to fetuses from lean dams. we have investigated the influence of thyroid hormone and gh status per se on these and other adipose tissue traits by chronically treating hypophysectomized (hypox) fetuses (day 70) between day 90 and 105 of gestation with either thyroxine (t ... | 1993 | 16350585 |
| relation of thyroid disfunction, thyroid autoantibodies, and renal function. | fifty-eight patients with thyroid dysfunction were included, comparing 27 healthy subjects to evaluate the relationship between thyroid autoimmunity, thyroid functional status, and renal function. regardless of clinical status, hypothyroidism was defined as t3-t4<normal limits and tsh>upper limit of normal, and hyperthyroidism was defined as t3-t4>normal limits and tsh <0.1 mcu/ml. in all participants, serum antithyroperoxidase level, serum antithyroglobulin level, creatinine clearance (cc), and ... | 2005 | 16350827 |
| sex differences in connexin-43 expression in left ventricles of aging rats. | cardiac gap junctions have been implicated in maintaining intercellular electrical and metabolic couplings. the abnormalities in connexin-43 (cx43) lead to conduction defects and contractile dysfunction. we have evaluated the expression and phoshorylation status of cx43 in the left ventricular myocardium of male and female 16-month-old rats submitted to 14-week l-thyroxine (t4) treatment. western blot analysis revealed the presence of fully or intermediately phosphorylated and unphosphorylated f ... | 2005 | 16351499 |
| clinical presentation of primary congenital hypothyroidism: experience before mass screening. | primary congenital hypothyroidism is a common preventable cause of mental retardation. neonatal thyroid screening is highly successful in early diagnosis and the improvement of developmental prognosis in the hypothyroid neonate. however, rarely cases could be missed, so doctors must be aware of the earl symptoms and signs of hypothyroidism. therefore, the purpose of this study was to emphasize the presenting clinical features of primary congenital hypothyroidism at the age of diagnosis. the stud ... | 2005 | 16351594 |
| the effect of selenium on thyroid status in a population with marginal selenium and iodine status. | the effects of se on thyroid metabolism in a new zealand population are investigated, including (a) the relationship between se and thyroid status, and (b) the effect of se supplementation on thyroid status. the data used come from two cross-sectional studies of se, i, thyroid hormones and thyroid volume (studies 1 and 4), and three se intervention studies in which thyroid hormones, se and glutathione peroxidase (gpx) activities were measured (studies 2, 3 and 5). there were no significant corre ... | 2005 | 16351774 |
| [near-total laryngectomy. experience, complications and acoustic analysis]. | to investigate the oncological efficiency, voice and complications of pearson's near-total laryngectomy for advanced laryngeal cancers (t3, t4). | 2005 | 16353789 |
| bone mineral density changes and bone turnover in thyroid carcinoma patients treated with supraphysiologic doses of thyroxine. | the aim of this one-year prospective study was to determine whether longterm thyroxine treatment is a risk factor for elevated bone turnover, loss of bone mass and subsequent development of osteoporosis. premenopausal women (n = 19), and men (n = 9) suffering from differentiated thyroid gland carcinoma in the mean age of 39.0 +/- 8.0 years and 41.8 +/- 10.0 years were investigated. all of them had undergone a total thyroidectomy and subsequent thyroxine therapy. the duration of the tsh-suppressi ... | 2005 | 16354602 |
| the effect of l-thyroxine supplementation on retinal vascular development in neonatal rats. | thyroxine (t4) plays a role in neuroretinal maturation, but little is known regarding its role in retinal vascularization. the neonatal rat retina is incompletely vascularized at birth, providing a model for the human premature infant retina and for retinopathy of prematurity (rop). we hypothesized that t4 supplementation would accelerate vascular development of normal neonatal rat retina. | 2005 | 16354616 |
| generalized correlation for biomolecular dynamics. | correlated motions in biomolecules are often essential for their function, e.g., allosteric signal transduction or mechanical/thermodynamic energy transport. because correlated motions in biomolecules remain difficult to access experimentally, molecular dynamics (md) simulations are particular useful for their analysis. the established method to quantify correlations from md simulations via calculation of the covariance matrix, however, is restricted to linear correlations and therefore misses p ... | 2006 | 16355416 |
| neurodevelopmental outcomes in congenital hypothyroidism: comparison of initial t4 dose and time to reach target t4 and tsh. | to compare neurodevelopmental outcomes in severe and moderate congenital hypothyroidism (ch) among 3 different initial l-thyroxine doses and to examine the effect of the time to thyroid function normalization on neurodevelopmental outcomes. | 2005 | 16356430 |
| [congenital transient hypothyroidism: characteristics of children identified at newborn screening program of the state of minas gerais, brazil]. | early diagnosis and treatment of congenital hypothyroidism are the main goals of the neonatal screening programs. a retrospective analysis was carried out to assess the characteristics and etiologies of congenital transient hypothyroidism (cth) in the newborn screening program of the state of minas gerais, brazil. to reach a diagnosis of cth, altered screening and serum confirmatory t4 and tsh tests and normal serum free t4 and tsh at 4 and 8 weeks after the withdrawal of levothyroxine were used ... | 2005 | 16358080 |
| [cost-effectiveness of the clinical treatment of grave's disease in a public university hospital: a retrospective analysis and prospective projection for a therapeutic approach]. | the aim of the present study was to evaluate a new proposal for increasing compliance to the clinical management of patients with graves' disease (gd) in a large and public university hospital. the patients were carefully selected (no previous gd treatment, goiter volume less than 6 ml must be living in the metro area of são paulo), received medication at no cost, were contacted frequently by the social worker and alerted for the date of consultation and only referred to a single endocrinologist ... | 2005 | 16358088 |
| treatment and follow-up of children with transient congenital hypothyroidism. | to study the clinical therapy and prognosis in children with transient congenital hypothyroidism (ch). | 2005 | 16358380 |
| metabolic differences in response to a high-fat vs. a high-carbohydrate diet. | energy expenditure was measured in a group of 7 subjects who received two isocaloric isonitrogenous diets for a period of 9-21 days with a 4-10-day break between diets. diet 1 was a high-fat diet ( 83.5 +/- 3.6% of total energy). diet 2 was a high carbohydrate diet ( 83.1 +/- 3.7% of total energy). resting and postprandial resting metabolic rate were measured by open circuit indirect calorimetry 2-4 times during each metabolic period. total energy expenditure (tee) was measured by the doubly lab ... | 1994 | 16358395 |
| [progression of larynx and hypopharynx cancer in the last ten years]. | epidemiological analysis of patients with the larynx and hypopharynx cancer, who were treated in the department of otolaryngology in bialystok from 1999 to 2004 was performed. the following aspect were assessed: (1) number of patients, (2) sex, (3) profession and place of living, (4) primary site of the tumour, (5) clinical advancement stage of the disease. the study was of 676 patients. the majority--92.2%--were males but an increase in number of female patients was found. the most common site ... | 2005 | 16358867 |
| [salvage surgery after failure of radiotherapy in laryngeal cancer]. | efficacy of salvage surgery after radiotherapy failure in patients with laryngeal cancer. | 2005 | 16358891 |
| acute phase proteins serum concentrations in children are related to urinary iodine excretion. | the paper presents links between iodine provision and selected acute phase proteins' (app) serum concentrations as well as their glycosylations profiles (investigated with the use of affinity immunoelectrophoresis with concanavalin a as ligand) in children. | 2005 | 16358983 |
| squamous cell carcinoma of the subglottis. | a retrospective study over a 25-year period of patients with laryngeal carcinoma treated by the department of otolaryngology at wake forest university. | 2006 | 16360814 |
| mycobacterium tuberculosis nad+-dependent dna ligase is selectively inhibited by glycosylamines compared with human dna ligase i. | dna ligases are important enzymes which catalyze the joining of nicks between adjacent bases of double-stranded dna. nad+-dependent dna ligases (liga) are essential in bacteria and are absent in humans. they have therefore been identified as novel, validated and attractive drug targets. using virtual screening against an in-house database of compounds and our recently determined crystal structure of the nad+ binding domain of the mycobacterium tuberculosis liga, we have identified n1, n(n)-bis-( ... | 2005 | 16361267 |
| positron emission tomography scanning is not superior to whole body multidetector helical computed tomography in the preoperative staging of colorectal cancer. | the role of positron emission tomography with the glucose analogue [18f] fluoro-2-deoxy-d-glucose (fdg-pet) in the initial staging of disease in patients with primary colorectal cancer (crc) has not been adequately assessed. | 2006 | 16361308 |
| evolution of hepatitis b virus in an acute hepatitis b patient co-infected with genotypes b and c. | the interactions between different genotypes of hepatitis b virus (hbv) in co-infected patients remain largely unknown, especially in acute infection. here, the evolution of hbv strains was studied in an acute, self-limited hepatitis b patient co-infected with genotypes ba (b2) and c. virological analyses were performed at four time points after admission: t1 (5 days), t2 (11 days), t3 (22 days) and t4 (260 days). a dominant-genotype change from genotype c to ba was found after anti-hbv e antige ... | 2006 | 16361416 |
| organ-preserving multimodality management of squamous cell carcinoma of anal canal. | to study the efficacy of an organ-preserving, sequential chemoradiation therapy for squamous cell carcinoma of the anal canal, and of salvage surgery in those in whom this treatment fails. | 2005 | 16361764 |
| sectional neuroanatomy of the middle thoracic spine (t5-t8) and chest. | this is the third in a series of articles on the spine. the first reviewed the anatomy of the neck. the second reviewed the upper thoracic spine and chest (t1-t4). a fourth article is planned for the lower thoracic spine. procedures in the midthoracic spine include chest tube placement, trigger point injections, chemodenervation with botulinum toxin, video-assisted thoroscopic surgery, and spinal injections. complications include pneumothorax, hemothorax, diaphragmatic irritation, sympathetic tr ... | 2006 | 16365594 |
| amiodarone-induced thyroid dysfunction in cardiac patients from areas with iodine deficiency. | amiodarone via iodine excess can determine thyroid dysfunction. | 2004 | 16366133 |
| [reconstruction after tumour's excision in lip's cancer: report of 100 cases]. | cancer of the lips is a frequent pathology, it represents 1/5 of cancers of the upper aerodigestive tract. its objectives are to present the experience of the plastic and reconstructive surgery unit of the universitary hospital of casablanca. | 2005 | 16366379 |
| [the outcome of treatments for carcinoma of the external auditory canal]. | a retrospective analysis of management and survival of patients treated for temporal bone carcinoma. | 2005 | 16366384 |
| charge transfer processes in conjugated triarylamine-oligothiophene-perylenemonoimide dendrimers. | the synthesis and charge transfer properties of triarylamine-oligothiophene-perylenemonoimide dendrimers, tpa(t2-pmi)3 and tpa(t4-pmi)3, are described. the fluorescence quantum yields indicate strong emission quenching by electron transfer [phi(thf) = 0.004 for tpa(t2-pmi)3, phi(thf) = 0.003 for tpa(t4-pmi)3, and phi(thf) = 0.8 for pmi]. moreover, with the increase of the solvent polarity, the quantum yields decrease indicating that the a+* d-* (acceptor/donor) couple is more stabilized. the fem ... | 2005 | 16366618 |
| detection of transgenic and endogenous plant dna fragments in the blood, tissues, and digesta of broilers. | the aim was to determine the fate of transgenic and endogenous plant dna fragments in the blood, tissues, and digesta of broilers. male broiler chicks (n = 24) were allocated at 1 day old to each of four treatment diets designated t1-t4. t1 and t2 contained the near isogenic nongenetically modified (gm) maize grain, whereas t3 and t4 contained gm maize grain [cry1a(b) gene]; t1 and t3 also contained the near isogenic non-gm soybean meal, whereas t2 and t4 contained gm soybean meal (cp4epsps gene ... | 2005 | 16366726 |
| comparison of effects of estradiol with those of octylmethoxycinnamate and 4-methylbenzylidene camphor on fat tissue, lipids and pituitary hormones. | octylmethoxycinnamate (omc) and 4-methylbenzylidene camphor (4mbc) are commercially used absorbers of ultraviolet (uv) light. in rats, they were shown to exert endocrine disrupting including uterotrophic, i.e. estrogenic effects. estrogens have also metabolic effects, therefore the impact of oral application of the two uv absorbers at 2 doses for 3 months on lipids and hormones were compared with those of estradiol-17beta (e2). e2, omc and 4mbc reduced weight gain, the size of fat depots and ser ... | 2006 | 16368123 |
| prognostic significance of metastasis to the highest mediastinal lymph node in nonsmall cell lung cancer. | we have tried to clarify the prognostic significance of metastasis to the highest mediastinal (hm) lymph node in patients with n2 lung cancer who underwent complete dissection of superior mediastinal (including hm) lymph nodes. | 2006 | 16368383 |
| continuous positive airway pressure breathing increases the spread of sensory blockade after low-thoracic epidural injection of lidocaine. | factors affecting the distribution of sensory blockade after epidural injection of local anesthetics remain incompletely clarified. to evaluate if increasing intrathoracic pressure affects the spread of thoracic epidural anesthesia, we randomized 20 patients who received an epidural catheter at the t7-8 or t8-9 intervertebral space into 2 groups. the control group (n = 10) received an epidural test dose of 4 ml lidocaine 2% during spontaneous breathing at ambient pressure. the continuous positiv ... | 2006 | 16368841 |
| effect of long-distance road transport on thyroid and adrenal function and haematocrit values in limousin cattle: influence of body weight decrease. | the purpose of this study was to evaluate the effect of long-distance road transport as a relevant stressor on total and free iodothyronines, cortisol levels and haematocrit values in 10 male limousin cattle. serum t3,t4,ft3,ft4 and cortisol concentrations were analysed by immunoenzymatic assays. serum cortisol levels and haematocrit modifications were also evaluated on the basis of percentage body weight decrease. the results showed a general increase of total and free iodothyronines and cortis ... | 2005 | 16369885 |
| thyroparathyroidectomy procedures and thyroxine levels in the chinchilla. | thyroid and embedded parathyroid glands were surgically removed (thyroparathyroidectomized) from adult chinchillas (chinchilla laniger) to create an animal model of hypothyroidism. thyroxine (t4) levels were measured at the time of surgery and one or two times after surgery from 10 thyroparathyroidectomized chinchillas and five sham controls to establish baseline serum t4 levels and to assess the degree and duration of hypothyroidism in this animal model. baseline t4 levels ranged from 3.4 to 6. ... | 2005 | 16370577 |
| t4 rectal cancer: analysis of patient outcome after surgical excision. | locally advanced rectal cancer dictates a major surgical undertaking, which includes en bloc resection of the rectum and all involved organs. the aim of this study was to evaluate patient outcome and compare multimodality treatment options after various surgical approaches from one institution for t4 rectal cancer. a retrospective chart review identified 24 patients who were operated on for advanced primary rectal cancer invading adjacent structures (t4) over a 5(1/2)-year period. the types of t ... | 2005 | 16372606 |
| a general two-step strategy to synthesize lariat rnas. | we describe a general and efficient two-step strategy for lariat rna synthesis. in the first step, a deoxyribozyme synthesizes 2',5'-branched rna. in the second step, t4 rna ligase closes the loop that completes the lariat. the loop-closure reaction can form either a natural or unnatural lariat isomer, depending on which of the two 3'-termini of the branched rna reacts with the lone 5'-end. we demonstrate two approaches to control formation of either lariat isomer. in conjunction with other rout ... | 2006 | 16373486 |
| morphologic comparison of cervical, thoracic, lumbar intervertebral discs of cynomolgus monkey (macaca fascicularis). | the aim was to analyze the morphological differences of the intervertebral disc and endplates at different levels. forty-five vertebral motion segments were obtained from the spine of nine 3 to 4-year-old cynomolgus monkeys (macaca fascicularis). from every spine, five discs were sectioned (c5-c6, t3-t4, t9-t10, l2-l3, l4-l5). in all the groups, tissue samples were collected and sections were stained with masson's trichrome, safranine-o and van gieson's connective tissue stain to analyze the int ... | 2006 | 16374650 |
| effects of selenium depletion and selenium repletion by choice feeding on selenium status of young and old laying hens. | we investigated the effect of choice feeding two diets with different selenium (se) content to young and old moderately se-deficient laying hens on serum se (sse), glutathione peroxidase (gpx), vitamin e, creatine kinase (ck), aspartate aminotransferase (asat), thyroxine (t4) and triiodothyronine (t3). each of two consecutive study parts (i and ii) with the same hens and treatments began with a 6-week baseline period (medium-se diet), followed by a 9-week depletion period (low-se or medium-se di ... | 2006 | 16376389 |
| structural analysis of peptides that interact with newcastle disease virus. | a peptide with the sequence ctlttklyc has previously been identified to inhibit the propagation of newcastle disease virus (ndv) in embryonated chicken eggs and tissue culture. ndv has been classified into two main groups: the velogenic group, and mesogenic with lentogenic strains as the other group based on its dissociation constants. in this study the peptide, ctlttklyc, displayed on the piii protein of a filamentous m13 phage was synthesized and mutated in order to identify the amino acid res ... | 2006 | 16377031 |
| gamma-irradiated recd overproducers become permanent recb-/c- phenocopies for extrachromosomal dna processing due to prolonged titration of recbcd enzyme on damaged escherichia coli chromosome. | the recbcd enzyme of escherichia coli consists of three subunits recb, recc and recd. recbcd enzyme activities are regulated by its interaction with recombination hotspot chi. biochemical and genetic evidence suggest that interaction with chi affects recd subunit, and that recd polypeptide overproduction antagonizes this interaction, suggesting that intact recd replaces a chi-modified one. we used bacteria with fragmented chromosomes due to double-strand breaks inflicted by uv and gamma-irradiat ... | 2006 | 16377056 |
| [influence of lidocaine on systemic inflammation in perioperative patients undergoing cardiopulmonary bypass]. | to investigate the influence of lidocaine on systemic inflammation in the perioperative ventricular septal defect (vsd). | 2005 | 16378115 |
| clinical and molecular features of a tsh-secreting pituitary microadenoma. | we describe a case of a thyroid stimulating hormone (tsh)-secreting pituitary microadenoma, and report the systematic gene expression profile of the surgically- removed tumor. a 50-year-old woman was referred to our hospital because she had high tsh, free-t4, and free-t3 levels, and a pituitary tumor that was visualized with magnetic resonance imaging. her basal tsh level was high even after a high t3 loading dose, and increased following administration of thyroid releasing hormone (trh) even af ... | 2005 | 16379036 |
| [diagnostic value of tissue polypeptide antigen in serum of larynx cancer patients]. | tissue polypeptide antigen (tpa) is a serological tumour marker used in the diagnosis, management and follow-up of patients with head and neck cancer. the aim of this study was to evaluate the diagnostic and prognostic significance of pretreatment tpa serum levels in patients with larynx cancer. the predicting ability of this tumour marker with respect to histological type, pathological state and lymph node metastasis was also assessed. | 2005 | 16379315 |
| methylprednisolone causes minimal improvement after spinal cord injury in rats, contrasting with benefits of an anti-integrin treatment. | spinal cord injury (sci) leads to complex secondary events that expand and exacerbate the injury. methylprednisolone (mp) has been considered a standard of care for acute sci. the purpose of this study was to test the effects of mp, in severe and more moderate severe clip-compression models of sci, on the measures of neurological function and lesion sparing that we used previously to assess a highly effective anti-inflammatory therapy, a monoclonal antibody (mab) to the cd11d integrin. intraveno ... | 2005 | 16379576 |
| unusual presentation of hypophysitis preceding an empty sella in a 75-year-old woman. | a 75-year-old woman complained about progressing fatigue. she appeared somnolent, but fully oriented and in no acute distress. her face was pale and puffy. she did not show any signs of focal neurological disease, and the remainder of the physical examination was unrevealing. routine laboratory tests were unremarkable except for hyponatremia and mildly decreased levels of free t3 and free t4, with tsh in the normal range. pituitary function tests demonstrated secondary adrenal insufficiency and ... | 2005 | 16380671 |
| effects of different antioxidants on lipid peroxidation in brain homogenates, induced by l-thyroxine administration in rats. | it is known that thyrotoxicosis induces lipid peroxidation (lpo). in contrast, propylthiouracil (ptu), a thyrostatic drug is a well-known antioxidant. also melatonin has been shown to protect against free radical-induced neuronal destruction. at the same time, it is generally accepted that the brain is the most vulnerable tissue to oxidative stress. | 2005 | 16380675 |
| neonatal hypothyroidism-induced changes in rat testis size, dependence on temperature. | effects of transient neonatal hypothyroidism (hpot) on adult testis size and serum hormone profiles were evaluated in the charles foster strain of rats, maintained under the temperature of 21 degrees c (hpotl) or of 34 degrees c (hpoth). | 2005 | 16380692 |
| exercise intensity and its effects on thyroid hormones. | physical activity influences energy metabolism in human subjects by increasing activity-induced energy expenditure and resting metabolic rate for several hours after exercise. effects of exercise on circulating thyroid hormone values remain controversial. we have investigated the effect of acute aerobic exercise on thyroid hormone values. | 2005 | 16380698 |
| accuracy of the funnel technique of thoracic pedicle screws insertion in scoliosis surgery--an evaluation by ct-scans. | pedicle screw system has increasingly been used for correction of thoracic scoliosis. it offers several biomechanical advantages over hook system as it controls all three-column of the spine with enhanced stability. of many techniques of pedicle screw placement in the thoracic spine, the funnel technique has been used in sarawak general hospital since 2002. this prospective study aims to assess the accuracy of the placement of thoracic pedicle screws using the funnel technique in the corrective ... | 2005 | 16381281 |
| interactions in developmental toxicology: concurrent exposure to perfluorooctane sulfonate (pfos) and stress in pregnant mice. | the maternal and developmental toxicity of combined exposure to restraint stress and perfluorooctane sulfonate (pfos) was assessed in mice. on gestation days 6-18, four groups of plug-positive female mice were orally exposed to pfos at 0, 1.5, 3 and 6 mg/kg/day. four additional groups of plug-positive animals received the same pfos doses being restrained during 30 min three times per day. a control group was also included. cesarean sections were performed on day 18 of gestation and fetuses were ... | 2006 | 16384669 |
| functional characterization of sequence motifs in the transit peptide of arabidopsis small subunit of rubisco. | the transit peptides of nuclear-encoded chloroplast proteins are necessary and sufficient for targeting and import of proteins into chloroplasts. however, the sequence information encoded by transit peptides is not fully understood. in this study, we investigated sequence motifs in the transit peptide of the small subunit of the rubisco complex by examining the ability of various mutant transit peptides to target green fluorescent protein reporter proteins to chloroplasts in arabidopsis (arabido ... | 2006 | 16384899 |
| thyroxine affects expression of kspg-related genes, the carbonic anhydrase ii gene, and ks sulfation in the embryonic chicken cornea. | opaque chick corneas become thin and transparent from embryonic day (e)9 to e20 of incubation. thyroxine (t4) injected in ovo on e9 induces precocious transparency by e12. the present study was conducted to determine whether corneal cells differentially express genes for t4 regulation, keratan sulfate proteoglycan (kspg) synthesis, crystallins, and endothelial cell ion transporters during transparency development and whether these expressions are altered when e9 embryos are treated with t4. | 2006 | 16384953 |
| comparison of the usage of intravenous iloprost and nitroglycerin for pulmonary hypertension during valvular heart surgery. | pulmonary hypertension secondary to valvular heart disease is a cause of acute right heart failure during valve replacement operations. this study compares the hemodynamic effects of intravenous use of iloprost and nitroglycerin in patients with pulmonary hypertension undergoing valvular replacement surgery. we sought to determine the acceptable doses of these medications for use in surgery to decrease mean pulmonary artery pressure to <30 mmhg without causing systemic side effects. the plasma n ... | 2006 | 16387672 |
| the effects of experimental hypothyroidism on hemorheology and plasma fibrinogen concentration. | effects of hypothyroid on hemorheology of patients had widely attracted the attention of researchers during last decade. the present study has been planned with the purpose to determine the effects of experimental hypothyroidism on hemorheological parameters and fibrinogen concentration. to induce experimental hypothyroid methimazole (75 mg/100 g) was added to the fodder of an experimental group rats for 20 d. after experimental duration, plasma and blood viscosity, hematocrit (hct), hemoglobin, ... | 2005 | 16388087 |
| a comparison of 25 gauge quincke spinal needle with 26 gauge eldor spinal needle for the elective caesarian sections: insertion characteristics and complications. | the study was designed to compare the insertion characteristics and incidence of pdph between 25 gauge quincke needle and 26 gauge eldor needle for spinal anaesthesia in elective c/s. | 2003 | 16388267 |
| effect of mirtazapine on thyroid hormones in adult patients with major depression. | hypothalamic pituitary thyroid (hpt) axis abnormalities and alterations in major depression are reported in the literature. the aim of our study was to evaluate the effect of mirtazapine on thyroid hormones after 6 months of therapy in a sample of adult outpatients with major depression (md). 17 adult outpatients (7 men, 10 women) with md according to dsm-iv criteria, were included in the study. all participants had to have met criteria for a major depressive episode with a score of at least 15 ... | 2005 | 16388723 |
| protective role of panax ginseng extract standardized with ginsenoside rg3 against acrylamide-induced neurotoxicity in rats. | acrylamide (acr) is an industrial neurotoxic chemical that has been recently found in carbohydrate-rich foods cooked at high temperatures. acr was designated as a probable human carcinogen by iarc (1994) and usepa (1988). panax ginseng extract has efficacies such as anticancer, antihypertension, antidiabetes and antinociception. the objective of the current study is to evaluate the protective effects of panax ginseng extract against acr-induced toxicity in rats. sixty adult sprague dawley female ... | 2006 | 16389659 |
| endocrine profiles and growth patterns of cloned goats. | two groups of goats produced by fetal somatic cell nuclear transfer (nt) were monitored to evaluate the similarities in growth patterns among cloned animals. clone group i consisted of five toggenburg females cloned from the same transgenic cell line and born to different recipient does. clone group ii consisted of two saanen does born as twins to a single recipient female from a second transgenic cell line. each cell line was constructed with a transgene (different for each clone group) that wo ... | 2005 | 16390257 |
| new rfp- and pes213-derived tools for analyzing symbiotic vibrio fischeri reveal patterns of infection and lux expression in situ. | genetically altered or tagged vibrio fischeri strains can be observed in association with their mutualistic host euprymna scolopes, providing powerful experimental approaches for studying this symbiosis. two limitations to such in situ analyses are the lack of suitably stable plasmids and the need for a fluorescent tag that can be used in tandem with green fluorescent protein (gfp). vectors previously used in v. fischeri contain the p15a replication origin; however, we found that this replicon i ... | 2006 | 16391121 |
| findings on 18f-fdg pet scans after neoadjuvant chemoradiation provides prognostic stratification in patients with locally advanced rectal carcinoma subsequently treated by radical surgery. | predicting outcome after aggressive therapy for advanced rectal cancer remains difficult. (18)f-fdg pet has emerged as a valid method for predicting patient outcomes after therapy in an increasing number of cancers. we evaluated the prognostic information obtained from the degree of change in tumor (18)f-fdg pet uptake induced by chemoradiation before radical curative surgery in patients with t3/t4 rectal cancer. | 2006 | 16391182 |
| quantification of ultraviolet-c irradiation induced cyclobutane pyrimidine dimers and their removal in beauveria bassiana conidiospore dna. | ultraviolet (uv) radiation-induced dna damage leading to entomopathogenic fungal inactivation is commonly measured by viability counts. here we report the first quantification of uv-induced cyclobutane pyrimidine dimers (cpd) in dna of the entomopathogenic fungus, beauveria bassiana. changes in the mobility of uv-c irradiated dna were resolved with cpd specific bacteriophage t4 endonuclease v and alkaline agarose gel electrophoresis. the maximum number of cpd formed in b. bassiana dna in vitro b ... | 2005 | 16392251 |
| thyroid morphology and function in adults with untreated isolated growth hormone deficiency. | gh influences thyroid function and anatomy. although goiter is frequent in acromegalic patients, the effects of gh deficiency (ghd) are difficult to assess, because hypopituitaric subjects who lack gh often also have a partial or complete deficit of tsh. | 2006 | 16394080 |
| clinical case seminar: a novel lhx3 mutation presenting as combined pituitary hormonal deficiency. | lhx3 encodes lim homeodomain class transcription factors with important roles in pituitary and nervous system development. the only previous report of lhx3 mutations described patients with two types of recessive mutations displaying combined pituitary hormone deficiency coupled with neck rigidity. | 2006 | 16394081 |
| a comparison of short-term changes in health-related quality of life in thyroid carcinoma patients undergoing diagnostic evaluation with recombinant human thyrotropin compared with thyroid hormone withdrawal. | thyroid carcinoma requires lifelong monitoring with serum thyroglobulin, radioactive iodine whole body scanning, and other imaging modalities. levothyroxine (l-t4) withdrawal for thyroglobulin measurement and whole body scanning increases these tests' sensitivities but causes hypothyroidism. recombinant human tsh (rhtsh) enables testing without l-t4 withdrawal. | 2006 | 16394083 |
| efficacy of cyto-chex blood preservative for delayed manual cd4 testing using dynal t4 quant cd4 test among hiv-infected persons in zambia. | manual cd4 tests such as dynal t4 quant (dynabeads, dynal biotech, oslo, norway) are less expensive alternatives to flow cytometry in resource-limited countries. whereas blood preservatives have proven useful for stabilizing blood samples to allow delayed cd4 testing by flow cytometry, they have not been verified for manual tests. a method for preservation of blood prior to manual cd4 testing is needed for long-distance transport or sample batching. | 2006 | 16394848 |
| assembly and infection process of bacteriophage t4. | bacterophage t4 consists of three parts, namely, a head, a tail, and six tail fibers, each of which is assembled along an independent pathway and then joined. in contrast to simple plant viruses such as tobacco mosaic virus, disassembly and reassembly of the virion is not possible. this is due mainly to the fact that the assembly involves not only irreversible steps such as cleavage of covalent bonds of some constituent proteins, but also that it requires a scaffold and involves the inner membra ... | 2005 | 16396595 |
| evaluation for surrogacy of end points by using data from observational studies: tumor downstaging for evaluating neoadjuvant chemotherapy in invasive bladder cancer. | in clinical cancer trials for evaluating neoadjuvant chemotherapy, tumor downstaging is frequently used as a surrogate end point for overall survival. we evaluated the surrogacy of tumor downstaging using data from a follow-up observational study in bladder cancer. | 2006 | 16397035 |
| [oral squamous cell carcinoma retrospective analysis of therapy results and prognosis by neoadjuvant, preoperative radio-chemotherapy]. | we investigated the charts of 129 patients treated for oral squamous cell carcinoma (scc) in the department of oral and maxillofacial surgery, university of cologne, between 1995 and 2004. only patients treated preoperatively with combined radio-chemotherapy (carboplatin/39.6 gy) were included. the purpose of the present study was to show the therapeutic outcome and the survival rates for this regimen. the mean age of the patients was 56.6 years. male patients outnumbered female patients by 3:1. ... | 2006 | 16397802 |
| effects of pressure support ventilation plus volume guarantee vs. high-frequency oscillatory ventilation on lung inflammation in preterm infants. | the aim of the present study was to evaluate if high-frequency oscillatory ventilation (hfov) might reduce lung inflammation in preterm infants with infant respiratory distress syndrome (rds) in comparison with the early application of another potentially lung-protective ventilation strategy, such as pressure support ventilation plus volume guarantee (psv + vg). infants at less than 30 weeks of gestation with rds were enrolled consecutively in the study if they required mechanical ventilation, a ... | 2006 | 16397875 |
| neonatal iodine deficiency: clinical aspects. | iodine is a trace element which is essential for the synthesis of thyroid hormones. the thyroid hormones, thyroxine (t4) and 3,5,3'-triiodothyronine (t3), are necessary for adequate growth and development throughout fetal and extrauterine life. the iodine intake of newborns is entirely dependent on the iodine content of breast milk and the formula preparations used to feed them. an inadequate iodine supply might be especially dangerous in the case of premature babies. the minimum recommended die ... | 2005 | 16398457 |
| serum leptin level in hypothyroid males. | to determine the correlation of serum leptin with thyroid hormones in primary hypothyroid male patients and euthyroid lean and obese control subjects. | 2005 | 16398964 |
| non-thyroidal illness syndrome is a manifestation of hypothalamic-pituitary dysfunction, and in view of current evidence, should be treated with appropriate replacement therapies. | this article documents the role of hypothalamic hypothyroidism and decreased t4-->t3 conversion as the cause of low t4 and t3 in non-thyroidal illness syndrome (ntis). this article also presents the arguments for administration of replacement triiodothyronine (t3) and thyroxine (t4) hormone in patients who have ntis. it is impossible to be certain at this time that it is beneficial to replace hormone, or whether this could be harmful. only a prospective study will be adequate to prove this point ... | 2006 | 16399020 |
| selection of patients with gastric adenocarcinoma for laparoscopic staging. | to refine selection criteria for laparoscopic staging of gastric adenocarcinoma, preoperatively available clinical and radiologic factors that may predict the risk of m1 disease were investigated. | 2006 | 16399124 |
| t3 and t4: are we missing half the picture? | | 2005 | 16399245 |
| potential uses of t3 in the treatment of human disease. | treatments for hypothyroidism have been available since the late 19th century, and have been continually improved by advancing our understanding of thyroid hormone pharmacology. thyroxine (t4) monotherapy is currently the standard of care, but may leave some hypothyroid symptoms unaddressed. triiodothyronine (t3), formed by the monodeiodination of t4, is the biologically active form of thyroid hormone based upon its ability to regulate gene expression at the nuclear level. a variety of human and ... | 2005 | 16399246 |
| can molecular imaging predict response to preoperative chemoradiation in patients with rectal cancer? a fox chase cancer center prospective experience. | this study was undertaken to correlate change in fluorine-18 fluorodeoxyglucose positron emission tomography ((18)fdg-pet) uptake with response to combined-modality neoadjuvant therapy in patients with locally advanced rectal cancer. twenty patients (13 male; 7 female) underwent (18)fdg-pet scans before and 3 to 4 weeks after completion of chemoradiation before surgery. staging by endoscopic ultrasound was t3/t4 (17/1); two patients were unable to undergo endorectal ultrasound. fifteen patients ... | 2005 | 16399435 |
| an echocardiographic study of cardiac changes in hypothyroidism and the response to treatment. | thyroid hormones exert a direct cellular effect on almost all the tissues of the body including heart. limited studies are available in the country to assess the various cvs parameters in hypothyroid patients and none have defined the impact of treatment on these parameters. | 2004 | 16400211 |
| differences in clinical characteristics and disease-free survival for latino, african american, and non-latino white men with localized prostate cancer: data from capsure. | few studies of ethnicity and prostate cancer have included latino men in analyses of baseline clinical characteristics, treatment selection, and disease-free survival (dfs). the present study examines the impact of latino ethnicity on these parameters in a large, multiinstitutional database of men with prostate cancer. | 2006 | 16400651 |
| comprehensive study of urinary cortisol metabolites in hyperthyroid and hypothyroid patients. | to further analyse the significance and mutual relationship of thyroid function-linked alterations in cortisol metabolism that have been separately and variously reported. | 2006 | 16402926 |
| investigations of thyroid hormones and antibodies based on a community health survey: the busselton thyroid study. | overt or subclinical thyroid dysfunction is common within the community, yet the significance of subtle anomalies in thyroid function tests remains contentious. the aims of this study were to: (a) establish reference intervals for serum-free thyroxine (ft4), thyroid-stimulating hormone (tsh) and thyroid antibodies (antithyroperoxidase, tpoab and antithyroglobulin, tgab) in the busselton community of south-western western australia; and (b) determine the prevalence of thyroid hormone anomalies in ... | 2006 | 16402936 |
| crystal structure of a dna polymerase sliding clamp from a gram-positive bacterium. | sliding dna clamps are processivity factors that are required for efficient dna replication. dna polymerases maintain proximity to nucleic acid templates by interacting with sliding clamps that encircle dna and thereby link the polymerase enzyme to the dna substrate. although the structures of sliding clamps from gram-negative bacteria (e. coli), eukaryotes, archaea, and t4-like bacteriophages are well-known, the structure of a sliding clamp from gram-positive bacteria has not been reported prev ... | 2006 | 16403212 |
| neoadjuvant interstitial high-dose-rate (hdr) brachytherapy combined with systemic chemotherapy in patients with breast cancer. | this is the first study investigating neoadjuvant interstitial high-dose-rate (hdr) brachytherapy combined with chemotherapy in patients with breast cancer. the goal was to evaluate the type of surgical treatment, histopathologic response, side effects, local control, and survival. | 2006 | 16404517 |
| [subclinical and manifested hypothyroidism as a consequence of thyroid autoimmune disease]. | chronic thyroiditis (hashimoto's disease) is a slowly developing persistent inflamation of the thyroid gland, which frequently leads to hypothyroidism. some of the up-to-date knowledge about hypothyroidism, both subclinical and manifested, caused by autoimmune disease, was presented. autoimmune thyroid gland disease can occur at any age, but predominantly affects women after periods of high emotional and physical stress or accidents, as well as during periods of hormonal changes. it can also dev ... | 2005 | 16405254 |
| [dilated cardiomyopathy associated with autoimmune disease of thyroid gland]. | congestive heart failure is the main cause of cardiovascular morbidity and mortality with more than one million hospitalizations per year. dilated cardiomyopathy is one of the main causes of congestive heart failure characterized by diminished function of the left, right or both ventricles and ejection fraction less than 40%. numerous studies reported that the diseases of thyroid gland among the patients with dilated cardiomiopathy were very frequent: with prevalence from 18% to 49%. the impaire ... | 2005 | 16405256 |
| [surgical treatment for 217 patients with bladder transitional carcinoma]. | bladder transitional cell carcinoma (tcc) is the most common cancer among urogenital neoplasms. surgical operation is the most effective therapy for tcc. this study was to explore surgical treatment for tcc and its clinical significance. | 2006 | 16405754 |
| dose-dependent reductions in spatial learning and synaptic function in the dentate gyrus of adult rats following developmental thyroid hormone insufficiency. | thyroid hormones are critical for the development and maturation of the central nervous system. although somatic and neurological effects are well documented following severe thyroid hormone deprivation, much less is known of the functional consequences of moderate levels of hormone insufficiency. we have previously demonstrated that severe thyroid hormone reductions in the postnatal period are associated with impairments in synaptic transmission in the dentate gyrus. the present study was perfo ... | 2006 | 16406011 |
| studies on cleavage of dna by n-phosphoryl branched peptides. | it was found that nalpha,nepsilon-di[n-(o,o-diisopropyl)phosphoryl-l-leucy]-l-lysyl-methyl ester (1) and nalpha,nepsilon-di[n-(o,o-diisopropyl)phosphoryl-l-phenylalanyl]-l-lysyl-methyl ester (2) could cleave supercoiled dna such as puc19 efficiently in 40 mm britton-robinson buffer. the cleavage activities for both were investigated by agarose gel electrophoresis. the t4 ligase experiments implied that the cleavage of dna occurs via a hydrolytic path. the results showed that the cleavage reactio ... | 2006 | 16406614 |
| cyclical changes of vertebral body heights and bone loss in healthy women after menopause. | annual changes in vertebral body heights (vhs) and lumbar bone mineral density (lbmd) were evaluated in 120 healthy pre- and post-menopausal women aged 45-74 years. subjects were divided into groups according to menstrual status and years since menopause (ysm). vertebral heights were evaluated, using radiological morphometry as the sum of anterior vertebral body heights (avhs) from t4 to l5 at baseline and exactly 12 months later. results indicate that the sum of vhs is inversely correlated with ... | 2006 | 16406764 |
| outcome of penile cancer in circumcised men. | we previously reported on a group of patients with post-circumcision carcinoma of the penis. we now study the long-term outcome of these patients. | 2006 | 16406995 |