| increased thyroxine sulfate levels in critically ill patients as a result of a decreased hepatic type i deiodinase activity. | marked changes in peripheral thyroid hormone metabolism occur in critical illness, resulting in low serum t3 and high rt3 levels. in this study, we investigated whether t4s levels are increased in patients who died after intensive care and whether t4s levels are correlated with liver type i deiodinase (d1) or sulfotransferase (sult) activity. | 2005 | 16189257 |
| structure and dynamics of the triplet state of oligothiophenes in isotropic and partially oriented matrices. | the photoexcited triplet states of 4,4'-dipentoxy-2,2'-dithiophene (4-t2), 3,3'-dipentoxy-2,2'-dithiophene (3-t2), and 4,4'''-dipentoxy-2,2':5',2'':5'',2'''-tetrathiophene (4-t4) have been investigated by time-resolved electron paramagnetic resonance in glassy toluene and in a frozen oriented liquid crystal, which provides a partially ordered medium. the preferential orientation of the rod-like 4-t2 and 4-t4 is compared to that of the disk-like 3-t2. the use of an oriented matrix coupled to simp ... | 2005 | 16189608 |
| [changes of cell adhesion molecules and proinflammatory cytokines during cardiopulmonary bypass and the effect of intervention]. | to investigate the changes of the cell adhesion molecules and proinflammatory cytokines during cardiopulmonary bypass, and to observe the effect of intervention with ulinastatin. | 2005 | 16190387 |
| elevated thyroid indices in children and adolescents with obsessive-compulsive disorder: effects of clomipramine treatment. | to examine the basal thyroid function in pediatric obsessive compulsive disorder (ocd) versus controls, and to explore the relation between baseline thyroid measures and response to clomipramine treatment, and the effects of treatment on thyroid hormones. | 2005 | 16190790 |
| topographic anatomy of bronchial arteries in the pig: a corrosion cast study. | the anatomy of porcine bronchial circulation has not been fully described. the purpose of this study was to investigate the extrapulmonary topographic anatomy of bronchial arteries in pig. ten pigs weighing 15-25 kg were studied. between one and four bronchial arteries were found in each pig. the bronchoesophageal artery (bea), tracheobronchial artery (tba), inferior bronchial artery (iba) and accessory bronchial artery (aba) were present in 10/10, 8/10, 6/10 and 2/10 animals, respectively. the ... | 2005 | 16191170 |
| hypotensive spinal cord infarction associated with vertebral body infarction after treatment with short-acting antihypertensive agent. | spinal cord infarction is a rare condition with heterogeneous causes. an 80-year-old diabetic woman was brought to the emergency department because of retrosternal pain and high blood pressure. twenty minutes after treatment with sublingual nitroglycerin and short-acting oral antihypertensive agent, blood pressure had dropped from 201/91 mm hg to 158/68 mm hg, followed by abrupt onset of weakness in lower limbs, urinary retention and sensory loss in bilateral t4-l1 levels and the left lower limb ... | 2005 | 16193186 |
| prevalence of thyroid autoimmunity in patients with pemphigus vulgaris. | among bullous diseases, pemphigus vulgaris (pv) is a classical variety of this type of skin disorders. to establish the real prevalence of thyroid abnormalities in such a disease, a prospective study was developed. for this reason, thyroid evaluation was performed in 15 consecutive patients who attended the dermatology clinic for pv and in a group of 15 healthy volunteers (control group) matched by age and gender. thyroid function was evaluated by measuring t3, t4 and tsh. the presence or absenc ... | 2005 | 16193707 |
| long-day suppressed expression of type 2 deiodinase gene in the mediobasal hypothalamus of the saanen goat, a short-day breeder: implication for seasonal window of thyroid hormone action on reproductive neuroendocrine axis. | in most animals that live in temperate regions, reproduction is under photoperiodic control. in long-day breeders such as japanese quail and djungarian hamsters, type 2 deiodinase (dio2) plays an important role in the mediobasal hypothalamus, catalyzing the conversion of prohormone t4 to bioactive t3 to regulate the photoperiodic response of the gonads. however, the molecular basis for seasonal reproduction in short-day breeders remains unclear. because thyroid hormones are also known to be invo ... | 2006 | 16195409 |
| pituitary hyperplasia secondary to primary hypothyroidism: a case report and review of the literature. | pituitary hyperplasia secondary to primary hypothyroidism has been reported in the literature in both adults and children. we report a case of a young woman who was diagnosed with hypothyroidism in her teenage years. despite frequent follow-up, her tsh levels remained greater than 100 miu/ml. a few years later, pituitary enlargement was found on an mri at a time when her tsh was 177 miu/ml and her free t4 was 0.2 ng/dl. observed administration of 600 mcg of l-thyroxine was performed to determine ... | 2005 | 16195776 |
| possible association between phages, hoc protein, and the immune system. | mammals have become "an environment" for enterobacterial phage life cycles. therefore it could be expected that bacteriophages adapt to them. this adaptation must comprise bacteriophage proteins. gp hoc seems to have significance neither for phage particle structure nor for phage antibacterial activity. it is evidently not necessary for the "typical" antibacterial actions of bacteriophages. but the rules of evolution make it improbable that gp hoc really has no function, and non-essential genes ... | 2006 | 16195787 |
| [a rare case of malabsorption of thyroid hormones]. | we describe the case of a 22-year old male undergoing a total thyroidectomy for euthyroid multi-nodular goitre (tsh: 1.6 microui/ml). he was discharged treated with lt4 100 mg id. after discharge, he went into full clinical and laboratorial hypothyroidism (tsh = 396 microui/ml). we were able to rule out failure to take the medication and concomitant use of drugs. in the evaluation of intestinal absorption, only the d-xylose test proved to be abnormal. after unsuccessful administration of oral t4 ... | 2004 | 16197861 |
| [transcriptional repression of the trh gene]. | the synthesis and secretion of thyroid hormones (th: t3, t4) must be strictly regulated. th act on their own production via a negative feedback system. the synthesis of thyrotropin-releasing hormone (trh), produced in the hypothalamus, and thyrotropin (tsh) in the pituitary is inhibited at the transcriptional level by th. trh and tsh stimulate production of th. an outstanding, still open, question is the molecular basis of t3-dependent transcription repression of trh and tsh genes. however, some ... | 2005 | 16197903 |
| effects of pregnancy on eating attitudes and disorders: a prospective study. | the aim of this prospective study was to investigate the effects of pregnancy on eating disorders (ed), dietary habits and body image perception. one hundred and fifty pregnant women were interviewed between the period january 2001 and may 2003. ninety-seven women completed the study and were divided in three subgroups: pregnant women with a positive history of dieting (n=37), pregnant women with a positive history of dieting with a complete diagnosis of a current ed (n=11) and pregnant women wi ... | 2005 | 16198191 |
| a phase i/ii study of neoadjuvant chemotherapy followed by radiation with boost chemotherapy for advanced t-stage nasopharyngeal carcinoma. | local recurrence is the most common site of failure for locally advanced nasopharyngeal carcinoma (npc) treated with neoadjuvant cisplatin/5-fluorouracil (pf) and definitive radiation at our center. based on this, we studied the addition of chemotherapy during the boost phase of radiation after neoadjuvant pf for advanced t-stage (t3-t4) npc. this strategy was based on theoretical radiosensitization with chemotherapy during accelerated repopulation of the tumor with relatively radioresistant clo ... | 2005 | 16199307 |
| can histopathologic assessment of circumferential margin after preoperative pelvic chemoradiotherapy for t3-t4 rectal cancer predict for 3-year disease-free survival? | this study set out to determine the impact of a positive circumferential resection margin (crm) (r1-r2) and pathologic downstaging on local recurrence and survival in patients with borderline resectable or unresectable rectal adenocarcinoma treated with neoadjuvant chemoradiotherapy (crt). | 2005 | 16199310 |
| [result analysis of perioperative radiotherapy and laryngeal preservation in hypopharyngeal and pyriform sinus squamous cell carcinoma]. | to evaluate perioperative radiotherapy and laryngeal preservation clinical result of hypopharyngeal pyriform sinus squamous cell carcinoma. | 2005 | 16200964 |
| [contralateral cervical lymph node metastasis in piriform sinus carcinoma]. | to evaluate relative factors affecting contralateral cervical lymph node metastasis in piriform sinus carcinoma. | 2005 | 16200965 |
| [construction of eukaryotic expression vector expressing hepatitis c virus ns5b and egfp fusion protein and establishment of stable transfected hepg2 cell line]. | to construct a eukaryotic expression vector for expressing hepatitis c virus (hcv) recombinant ns5b-egfp fusion protein and obtain a stable transfected hepg2 cell line. | 2005 | 16201473 |
| hemodynamic, hepatorenal, and postoperative effects of desflurane-fentanyl and midazolam-fentanyl anesthesia in coronary artery bypass surgery. | the purpose of this study was to compare the hemodynamic, hepatorenal, and postoperative effects of desflurane-fentanyl and midazolam-fentanyl anesthesia during coronary artery bypass surgery. | 2005 | 16202892 |
| a prospective, double-blind, randomized, placebo-controlled study of dexmedetomidine as an adjunct to epidural analgesia after thoracic surgery. | the purpose of this study was to test the hypothesis that after thoracic surgery, the supplementation of a low-dose thoracic epidural (ed) bupivacaine (0.125%) infusion by intravenous (iv) dexmedetomidine decreases analgesic requirement without causing respiratory depression. the primary endpoint was the need for additional ed bupivacaine administered through patient-controlled epidural analgesia (pcea). secondary endpoints included the requirement for supplemental opioids and the impact of dexm ... | 2005 | 16202898 |
| decrease of functional coupling between left and right auditory cortices during dichotic listening: an electroencephalography study. | the present study focused on functional coupling between human bilateral auditory cortices and on possible influence of right over left auditory cortex during dichotic listening of complex non-verbal tones having near (competing) compared with distant non-competing fundamental frequencies. it was hypothesized that dichotic stimulation with competing tones would induce a decline of functional coupling between the two auditory cortices, as revealed by a decrease of electroencephalography coherence ... | 2005 | 16203106 |
| circadian and stimulated thyrotropin secretion in cranially irradiated adult cancer survivors. | it has been claimed that with the use of the trh test and knowledge of the nocturnal tsh surge, the diagnosis of so-called hidden central hypothyroidism might be uncovered in a substantial proportion of euthyroid cranially irradiated children. | 2005 | 16204362 |
| ligand binding at the transthyretin dimer-dimer interface: structure of the transthyretin-t4ac complex at 2.2 angstrom resolution. | the crystal structure of the complex of human transthyretin (httr) with 3,3',5,5'-tetraiodothyroacetic acid (t4ac) has been determined to 2.2 angstrom resolution. the complex crystallizes in the orthorhombic space group p2(1)2(1)2, with unit-cell parameters a = 43.46, b = 85.85, c = 65.44 angstrom. the structure was refined to r = 17.3% and r(free) = 21.9% for reflections without any sigma-cutoff. t4ac is bound in both the forward and the reverse mode in the two binding sites of httr. in the for ... | 2005 | 16204882 |
| a genome-wide search for alleles and haplotypes associated with autism and related pervasive developmental disorders on the faroe islands. | the involvement of genetic factors in the etiology of autism has been clearly established. we undertook a genome-wide search for regions containing susceptibility genes for autism in 12 subjects with childhood autism and related pervasive developmental disorders (pdds) and 44 controls from the relatively isolated population of the faroe islands. in total, 601 microsatellite markers distributed throughout the human genome with an average distance of 5.80 cm were genotyped, including 502 markers i ... | 2006 | 16205737 |
| oral and pharyngeal cancer: analysis of patient delay at different tumor stages. | the aim of this study was to examine which factors are related to patient delay in a cohort of consecutive patients with pharyngeal cancer and oral cancer and to determine whether the different stages of patient delay (ie, appraisal, illness, behavioral, and scheduling) were related to different tumor stages. | 2005 | 16206281 |
| [sedation and study of hormone dynamics in patients with severe brain injury during early postoperative period]. | the paper presents the results of an investigation of the effect of sodium oxybutyrate, thiopental sodium, and propofol on the blood levels of cortisol, acth, tth, t4 and t3 in patients with severe brain injury who have received artificial ventilation. the investigations showed that laboratory signs of the low t3-syndrome appeared by postoperative day 3 in all the patients. in patients receiving propofol, the manifestations of this syndrome were less pronounced and the parameters became normal m ... | 2005 | 16206588 |
| radiation-induced spinal cord cavernous malformation. case report. | the authors report a case of a 16-year-old girl who presented with progressive gait difficulty 8 years after undergoing spinal radiation therapy for spinal astrocytoma. magnetic resonance imaging revealed intramedullary multicentric cavity formation in the t4-10 area. extensive subtotal resection was performed and a pathological examination of the excised tissue demonstrated cavernous malformation with radiation-induced degeneration in the surrounding vessels. this is believed to be the third ca ... | 2005 | 16206743 |
| locally advanced differentiated thyroid carcinoma: a 35-year mono-institutional experience in 280 patients. | debate exists in the literature about the optimal treatment to be adopted in patients with locally advanced differentiated thyroid carcinoma. we aimed to better define the most appropriate diagnostic and therapeutic protocol for this type of tumour. | 2005 | 16208173 |
| as fast and selective as enzymatic ligations: unpaired nucleobases increase the selectivity of dna-controlled native chemical pna ligation. | dna-controlled reactions offer interesting opportunities in biological, chemical, and nanosciences. in practical applications, such as in dna sequence analysis, the sequence fidelity of the chemical-ligation reaction is of central importance. we present a ligation reaction that is as fast as and much more selective than enzymatic t4 ligase-mediated oligonucleotide ligations. the selectivity was higher than 3000-fold in discriminating matched from singly mismatched dna templates. it is demonstrat ... | 2005 | 16208732 |
| addendum: site-directed mutagenesis using pfu dna polymerase and t4 dna ligase. | | 2005 | 16208829 |
| [spinal cord and vertebral column injuries in children]. | analysis of main factors of spinal cord and vertebral column injuries in our environment. | 2005 | 16209374 |
| microsatellite instability and proliferating activity in sinonasal carcinoma: molecular genetic and immunohistochemical comparison with oral squamous cell carcinoma. | sinonasal carcinomas arise from the respiratory epithelium that lines the nasal and paranasal cavities, and are histologically composed of either squamous or cylindrical cell carcinoma. however, molecular analysis with the purpose of distinguishing sinonasal carcinomas from other head and neck squamous cell carcinomas (hnsccs), which arise from squamous epithelium, has been limited. moreover, a wide range of frequency of microsatellite instability (msi) in hnscc has been reported. using high-res ... | 2005 | 16211276 |
| chemoradiotherapy for t3 and t4 squamous cell carcinoma of the esophagus using low-dose fp and radiation: a preliminary report. | we conducted this study to evaluate the clinical significance of preoperative concurrent chemoradiotherapy (crt) followed by esophagectomy in the management of t3 and t4 esophageal cancer. thirty patients with squamous cell carcinoma of the esophagus received crt followed by surgery. preoperative crt consisted of 5-fluorouracil (500 mg/m(2) by 24 h infusion for 5 days), cisplatin (15 mg/m(2) on days 1-5), and concurrent radiotherapy (a total dose of 40 gy delivered in daily fractions of 2 gy, 5 ... | 2005 | 16211282 |
| which is responsible for the haemodynamic response due to laryngoscopy and endotracheal intubation? catecholamines, vasopressin or angiotensin? | we have investigated the concentrations of epinephrine, norepinephrine, vasopressin and angiotensin converting enzyme activity to explore the role of these mediators in the neuroendocrine response to laryngoscopy and tracheal intubation. | 2005 | 16211744 |
| anterior cervicothoracic junction corpectomy and plate fixation without sternotomy. | exposure of the lower cervical and upper thoracic spinal regions through a cervical incision without sternotomy has been described in cases of anterior decompression and methylmethacrylate vertebral body reconstruction. the use of anterior instrumentation and structural bone grafts in this procedure has not been well described. | 2002 | 16212334 |
| preliminary results of radiation dose escalation for locally advanced nasopharyngeal carcinoma. | to study the safety and efficacy of dose escalation in tumor for locally advanced nasopharyngeal carcinoma (npc). | 2006 | 16213105 |
| oxygen-modifying treatment with arcon reduces the prognostic significance of hemoglobin in squamous cell carcinoma of the head and neck. | to evaluate the prognostic significance of hemoglobin (hb) levels measured before and during treatment with accelerated radiotherapy with carbogen and nicotinamide (arcon). | 2006 | 16213107 |
| the incidence of sheehan's syndrome after obstetric hemorrhage. | to estimate the incidence of sheehan's syndrome in a well-described cohort of patients with obstetric hemorrhage. | 2005 | 16213852 |
| a cdna for a putative type iii deiodinase in the trout (oncorhynchus mykiss): influence of holding conditions and thyroid hormone treatment on its hepatic expression. | a putative rainbow trout type iii deiodinase (d3) cdna was amplified by pcr, using primers to evolutionarily conserved sequences. the race-derived complete cdna was then identified by sequence comparison to that in tilapia and other vertebrates. the cdna coded for a predicted 31,500 kda protein of 278 amino acids, with a hydrophobic trans-membrane segment and with 80% similarity to tilapia d3 and 39% similarity to rainbow trout type ii deiodinase (d2). it also showed a selenocysteine codon at po ... | 2006 | 16214142 |
| dipolar coupling between nitroxide spin labels: the development and application of a tether-in-a-cone model. | a tether-in-a-cone model is developed for the simulation of electron paramagnetic resonance spectra of dipolar coupled nitroxide spin labels attached to tethers statically disordered within cones of variable halfwidth. in this model, the nitroxides adopt a range of interprobe distances and orientations. the aim is to develop tools for determining both the distance distribution and the relative orientation of the labels from experimental spectra. simulations demonstrate the sensitivity of electro ... | 2006 | 16214868 |
| vaccination against very virulent infectious bursal disease virus using recombinant t4 bacteriophage displaying viral protein vp2. | in order to develop a desirable inexpensive, effective and safe vaccine against the very virulent infectious bursal disease virus (vvibdv), we tried to take advantage of the emerging t4 bacteriophage surface protein display system. the major immunogen protein vp2 from the vvibdv strain hk46 was fused to the nonessential t4 phage surface capsid protein, a small outer capsid (soc) protein, resulting in the 49 kda soc-vp2 fusion protein, which was verified by sodium dodecylsulfate polyacrylamide ge ... | 2005 | 16215632 |
| an investigation of dna mismatch repair capacity under normal culture conditions and under conditions of supra-physiological challenge in human cd4+t cell clones from donors of different ages. | t cells undergo rapid clonal expansion upon antigenic stimulation to produce an effective immune response. any defect in the dna mismatch repair (mmr) system may have a detrimental effect on t cell proliferation. this study employed an in vitro model of human cd4+t cell ageing to investigate mmr capacity at various stages of t cell lifespan. a novel modification of the alkaline comet assay, which utilised t4 endonuclease vii to detect single base dna mismatches, was used to assess dna mismatch f ... | 2005 | 16216462 |
| effect of 10 yr of the iodine supplementation on the hearing threshold of iodine deficient schoolchildren. | auditory disturbances may be present in iodine deficient children. the aim of this study was to determine the effect of long-term iodine supplementation on auditory thresholds in iodine deficient children. | 2005 | 16218041 |
| a case-controlled study on the quality of life in a cohort of patients with history of differentiated thyroid carcinoma. | although quality of life (qol) has become an important aspect of cancer rehabilitation, psychometric studies on thyroid cancer patients are rare. we performed a case-controlled study on qol in patients with differentiated thyroid carcinoma (dtc). qol was evaluated in 61 patients with a history of dtc diagnosed from < 1 to 23 yr earlier. an undetectable thyroglobulin (tg) level after recombinant human tsh (rhtsh) testing was considered the best predictor of cure. qol was evaluated by means of a g ... | 2005 | 16218042 |
| lack of tsh inhibition by exogenous l-t4 in a patient with follicular thyroid carcinoma. | we report a case of a male patient thyroidectomized for follicular thyroid carcinoma and presenting extremely elevated serum thyrotropin levels under l-t4 suppressive therapy. administration of l-t3 in increasing amounts resulted in a significant decrease of serum tsh levels. the nature of the possible molecular defects underlying this unusual condition and pitfalls arising from the failure of l-t4 therapy to inhibit tsh secretion in a patient in post-surgical follow-up for follicular carcinoma ... | 2005 | 16218052 |
| regulation of the pituitary growth hormone-releasing hormone receptor in ageing male and female lou rats: new insights into healthy ageing. | ageing is characterised by a decrease of somatotroph functionality, involving growth hormone-releasing hormone receptor (ghrh-r). the present study was conducted in lou/c/jall (lou) rats, a strain described as a model of healthy ageing, which is characterised by a low adiposity and long life expectancy without developing severe pathologies. effects of age and diet (chow versus self-selection), on levels of anterior pituitary ghrh-r mrna transcripts, were assessed in male and female lou rats. the ... | 2005 | 16218997 |
| [staging 915 cases of nasopharyngeal carcinoma after simple radical radiotherapy--checkout of fuzhou staging system (1992)]. | along with the development of treatments, different tumor staging systems are coexisted and have been modified. this study was to validate the rationality of the fuzhou staging system (1992) of nasopharyngeal carcinoma (npc), and to provide some suggestions. | 2005 | 16219127 |
| [cpg island methylation of e-cadherin gene promoter in gastric carcinoma]. | transcriptional silencing by cpg island methylation is now believed to be an important mechanism of carcinogenesis. e-cadherin can suppress tumor cell invasion and metastasis, and is considered as an invasion/metastasis suppressor gene. inactivation of e-cadherin gene often occurs in poorly differentiated gastric carcinoma. this study was to investigate the cpg island methylation status of e-cadherin gene promoter in primary human gastric carcinomas and adjacent gastric tissues, and to explore t ... | 2005 | 16219136 |
| [impact of dose boost in skull base on recurrence of stage t4 nasopharyngeal carcinoma]. | the recurrence rate in skull base is high for nasopharyngeal carcinoma (npc) patients with cavernous sinus or/and sphenoid sinus involvement. this study was conducted to explore the impact of dose boost in skull base on the recurrence in skull base and survival of npc patients with cavernous sinus or/and sphenoid sinus involvement. | 2005 | 16219141 |
| [graves' disease in preschool children]. | graves' disease, which is the main cause of hyperthyroidism in the pediatric age group, is very rare in pre-school children. we describe the cases of four girls, aged less than 6 years old, out of a total of 30 patients diagnosed with graves' disease between 1985 and 2004. investigations were motivated by tachycardia, chronic diarrhea, language development delay or thyroid nodules detected by cervical ultrasonography. in three of the four patients height and bone age were advanced. in all patien ... | 2005 | 16219281 |
| t-screen to quantify functional potentiating, antagonistic and thyroid hormone-like activities of poly halogenated aromatic hydrocarbons (phahs). | the present study investigates chemical thyroid hormone disruption at the level of thyroid hormone receptor (tr) functioning. to this end the (ant)agonistic action of a series of xenobiotics was tested in the newly developed t-screen. this assay makes use of a gh3 rat pituitary cell line, that specifically proliferates when exposed to 3,3',5-triiodo-l-thyronine (t3). the growth stimulatory effect is mediated via t3-receptors. (ant)agonistic and potentiating action of compounds was studied in abs ... | 2006 | 16219445 |
| phase ii study of preoperative oxaliplatin, capecitabine and external beam radiotherapy in patients with rectal cancer: the radioxcape study. | preoperative radiotherapy has been shown to decrease the local recurrence rate of patients with locally advanced rectal cancer. capecitabine and oxaliplatin are both active anticancer agents in the treatment of patients with advanced colorectal cancer and have radiosensitizing properties. therefore, these drugs would be expected to improve effectiveness of preoperative radiotherapy in terms of local control and prevention of distant metastases. | 2005 | 16219623 |
| thyrotropin suppression by metformin. | drug-drug interactions are common but often are discovered only long after initial drug release. metformin has been available in the united states for 9 yr and elsewhere for many years, but as of yet there are no reports that the drug modifies thyroid hormone economy. | 2006 | 16219720 |
| endoscopic ultrasound-guided fine-needle aspiration in the diagnosis and staging of lung cancer and its impact on surgical staging. | the diagnosis and staging of lung cancer critically depends on surgical procedures. endoscopic ultrasound (eus) -guided fine-needle aspiration (fna) is an accurate, safe, and minimally invasive technique for the analysis of mediastinal lymph nodes (lns) and can additionally detect tumor invasion (t4) in patients with centrally located tumors. the goal of this study was to assess to what extent eus-fna could prevent surgical interventions. | 2005 | 16219935 |
| organ-sparing treatment in muscle-invasive bladder cancer. | organ-sparing treatment of bladder cancer by a trimodality approach is feasible and effective. in this study, the results of a series of patients are reported, who were, in the majority, not suitable for major surgery. | 2005 | 16220401 |
| targeted disruption of the type 1 selenodeiodinase gene (dio1) results in marked changes in thyroid hormone economy in mice. | the type 1 deiodinase (d1) is thought to be an important source of t3 in the euthyroid state. to explore the role of the d1 in thyroid hormone economy, a d1-deficient mouse (d1ko) was made by targeted disruption of the dio1 gene. the general health and reproductive capacity of the d1ko mouse were seemingly unimpaired. in serum, levels of t4 and rt3 were elevated, whereas those of tsh and t3 were unchanged, as were several indices of peripheral thyroid status. it thus appears that the d1 is not e ... | 2006 | 16223863 |
| thyroid function during pregnancy in women with past graves' disease. | graves' disease and thyroid dysfunction during pregnancy can lead to maternal and fetal complications. no information is available on thyroid function in women with a past history of graves' disease. we compared free t3, free t4 and tsh in a group of pregnant women with a history of resolved graves' disease requiring no current treatment (n= 34) and in a group of pregnant controls (n= 102). we found no significant differences in the levels of these hormones between the two groups. women with a p ... | 2005 | 16225580 |
| transcription and rna processing during expression of genes preceding dna ligase gene 30 in t4-related bacteriophages. | early gene expression in bacteriophage t4 is controlled primarily by the unique early promoters, while t4-encoded regb endoribonuclease promotes degradation of many early messages contributing to the rapid shift of gene expression from the early to middle stages. the regulatory region for the genes clustered upstream of dna ligase gene 30 of t4 was known to carry two strong early promoters and two putative regb sites. here, we present the comparative analysis of the regulatory events in this reg ... | 2006 | 16225899 |
| [indications of the association of radiotherapy and hormonal treatment in prostate cancer]. | rtog and eortc randomised phase iii trials investigated combination of radiation therapy and hormonal treatment in locally advanced prostate cancer t2c-t4 n0-1 m0 (uicc 2002). complete androgen blockade initiated 2 months prior to starting radiotherapy and stopped at the completion of radiotherapy vs radiation therapy alone, increased overall survival in patients with gleason score 2-6. adjuvant androgen suppression started at the end of the radiotherapy and continued indefinitely improved signi ... | 2005 | 16226044 |
| a novel mutation in the monocarboxylate transporter 8 gene in a boy with putamen lesions and low free t4 levels in cerebrospinal fluid. | we describe brain lesions in a patient with a monocarboxylate transporter 8 mutation. imaging showed a high t2 lesion in the left putamen at age 3 and a right putamen lesion at age 6. cerebrospinal fluid free thyroxine concentrations were low, with normal 3,3',5-triiodothyronine concentrations. | 2005 | 16227048 |
| densitometric evaluation of skull and jaw bones after administration of thyroid hormones in rats. | an investigation was performed by use of optical densitometry to observe the effects of different doses of thyroid hormone on bone density of skull and jaw bones and to evaluate the relationship between t3, t4, thyroid stimulating hormone (tsh) serum levels and bone density. | 2005 | 16227474 |
| upper thoracic myelopathy caused by vertebral collapse and subluxation in rheumatoid arthritis: report of two cases. | we report two cases of rheumatoid arthritis (ra) with upper thoracic myelopathy and a review of the literature. clinical data of a 47-year-old woman (case 1) and a 54-year-old woman (case 2) are described. case 1 showed a transverse-type myelopathy at the t2 segment level of the spinal cord and case 2 had the same type of myelopathy at the t4 segment level. case 1 had anterior vertebral subluxation of c7 due to marked vertebral collapse and case 2 had subluxation of t2 with vertebral destruction ... | 2004 | 16228683 |
| follow up of patients with postpartum thyroiditis: a population-based study. | in this survey we studied the prevalence of permanent hypothyroidism and prognostic factors for its occurrence 3-5 yr after postpartum thyroiditis (ppt); 54 of 120 women with ppt and 50 of 920 healthy women from among 1,040 women followed 4-5 yr earlier for ppt were recalled. demographic information, signs, and symptoms of thyroid disorders and results of physical exams were documented. serum t3, t4, rt3u, tsh, and anti-thyroperoxidase (anti-tpo ab) and anti-thyro-gluboline (anti-tg ab) antibodi ... | 2005 | 16230784 |
| influence of low protein diet on nonthyroidal illness syndrome in chronic renal failure. | renal failure causes alterations in thyroid hormone metabolism known as nonthyroidal illness syndrome. in the present study we have examined the effect of a low protein diet (lpd) on circulating levels of hormones of the pituitary-thyroid axis, and tumor necrosis factor alpha (tnf-alpha) in patients with chronic renal failure. seventeen subjects with conservatively treated chronic renal failure (estimated creatinine clearance 39.5+/-11.1 ml/min) were studied before and after 8 wk of dietary inte ... | 2005 | 16230785 |
| design of ligand binding to an engineered protein cavity using virtual screening and thermal up-shift evaluation. | proteins could be used to carry and deliver small compounds. as a tool for designing ligand binding sites in protein cores, a three-step virtual screening method is presented that has been optimised using existing data on t4 lysozyme complexes and tested in a newly engineered cavity in flavodoxin. the method can pinpoint, in large databases, ligands of specific protein cavities. in the first step, physico-chemical filters are used to screen the library and discard a majority of compounds. in the ... | 2005 | 16231201 |
| characterization of oxygen-dependent lysis of escherichia coli cells infected by bacteriophage t4. | infection of escherichia coli cells by t4 phage at a multiplicity of infection (moi) of 0.01 caused inhibition of cell lysis for up to 4 h. such cells grown under aerobic condition were lysed by external stimuli such as cold shock, osmotic shock or addition of toxic substances, e.g., carbonyl cyanide m-chlorophenylhydrazone (cccp). however, the effects of these external stimuli were reduced by transferring the cells to static incubation, by which dissolved oxygen was consumed by the cells within ... | 2000 | 16232751 |
| ten-year follow-up of children born at <30 weeks' gestational age supplemented with thyroxine in the neonatal period in a randomized, controlled trial. | thyroid hormones are essential for brain development. we conducted a randomized, controlled trial with thyroxine (t4) supplementation in infants <30 weeks' gestation and with the last neurodevelopmental follow-up moment at the age of 5.5 years. t4 supplementation was associated with improved outcome of infants <28 weeks' gestation and worse outcome of infants of 29 weeks' gestation. we studied gestational age-dependent effects of t4 supplementation at the mean age of 10.5 years in children parti ... | 2005 | 16234230 |
| increased pulse wave velocity in subclinical hypothyroidism. | subclinical hypothyroidism affects 5-15% of the general population and is associated with increased morbidity from cardiovascular disease. brachial-ankle pulse wave velocity (bapwv) is a parameter of arterial stiffening and a good independent predictor for the presence of coronary artery disease. this study was performed to assess whether subclinical hypothyroidism might cause enhanced bapwv. | 2006 | 16234303 |
| excimer laser trabeculotomy: a new, minimally invasive procedure for patients with glaucoma. | excimer laser trabeculotomy (elt) ab interno is a new surgical technique to reduce intraocular pressure (iop) in patients with glaucoma or ocular hypertension. our purpose was to examine iop reduction and the use of antiglaucoma drugs (agd) in patients treated with elt and to evaluate the safety of this laser treatment. | 2006 | 16235060 |
| [surgical resection of t3 and t4 lung cancer]. | lung cancer invading neighboring anatomical structures such as the chest wall, pericardium, diaphragm, and left atrium are categorized as t3 or t4, which is regarded as locally advanced lung cancer. the purpose of this study was to evaluate results of surgical treatment of t3-4n0-2m0 non-small cell lung cancer according to involved organs. from 1981 to april 2005, 148 patients with lung cancer invading neighboring organs were surgically treated in our hospital. the 5-year survival was 41.4% in a ... | 2005 | 16235842 |
| [surgical resection for t4 lung cancer invading thoracic aorta]. | the prognosis of the lung cancer patients with aortic invasion is thought to be very poor in general. thoracic aorta resection and reconstruction was performed in 6 patients, aortic arch in 2, descending aorta in 4. an intraoperative and a postoperative major complication occurred in each 1 patient. five patients survived more than 1 year after operation, and 1 of them has been living without relapse for more than 5 years. pulmonary resection with the involved aorta can be done safely using card ... | 2005 | 16235844 |
| [the effect of multimodality induction therapy for locally advanced non-small cell lung cancer]. | in this study we analyzed induction therapy for locally advanced non-small cell lung cancer. eligible patients had mediastinoscopic proven n2 disease and t4 with mediastinal involvement. from january 1997 to may 2005, 56 patients entered the study. they received 2 cycle chemotherapy (platinums based 2 or 3 drugs), in 32 patients with concurrent radiotherapy followed by surgery. response rates were 57.1%. fifty-one patients underwent surgery. a radical resection was possible in 39 patients. compl ... | 2005 | 16235845 |
| [surgical treatment for locally advanced lung cancer; therapeutic response of induction chemotherapy and postoperative chemotherapy]. | the current chemotherapy has been able to give us many options to treat for lung cancer and recent studies have showed that perioperative chemotherapy may improve survival. in this study, we compared 2 groups with locally advanced lung cancers (stage iii, t3n0m0, inclusive of ipsilateral pm2, d1 and d2) ; group a, which had been treated by chemotherapy for downstaging prior to surgery (n = 23), and group b, which had been treated by surgery alone (n = 48). the postoperative 3- and 5-year overall ... | 2005 | 16235846 |
| [successful removal of t4 lung cancer with left atrial invasion after induction chemotherapy]. | a 53-year-old man presented with cough, sputa and chest pain. the chest x-ray revealed a large mass shadow in the right lower lobe. massive tumor extending into the left atrium was diagnosed by computed tomography (ct). the brushing cytology by broncoscopy was squamous cell carcinoma and its stage was iiib. chemothrapy using cisplatin, paclitaxel and gemcitabine hydrochloride was performed 8 courses during 6 months. the effect of the chemotherapy was complete response, enabling the surgical trea ... | 2005 | 16235848 |
| monoacetylcurcumin: a new inhibitor of eukaryotic dna polymerase lambda and a new ligand for inhibitor-affinity chromatography. | we previously reported that a phenolic compound, curcumin (diferuloylmethane), was a selective inhibitor of dna polymerase lambda (pol lambda) in vitro [y. mizushina, m. hirota, c. murakami, t. ishidoh, s. kamisuki, n. shimazaki, m. takemura, m. perpelescu, m. suzuki, h. yoshida, f. sugawara, o. koiwai, k. sakaguchi, some anti-chronic inflammatory compounds are dna polymerase lambda-specific inhibitors, biochem. pharmacol. 66 (2003) 1935-1944.]. we also found that monoacetylcurcumin ([1e,4z,6e]- ... | 2005 | 16236265 |
| the binding of xanthone derivatives to transthyretin. | a series of xanthone derivatives, isolated from calophyllum teysmannii var. inophylloide, have been evaluated for their binding affinity to transthyretin. transthyretin is a plasma protein involved in the transport of thyroxine (t4) and also implicated in amyloid diseases. using competition-binding studies with the protein natural ligand t4, we have identified one prenylated xanthone with a very strong affinity to transthyretin. molecular docking simulations show that the flexible tail of the pr ... | 2005 | 16236271 |
| the human cd94 gene encodes multiple, expressible transcripts including a new partner of nkg2a/b. | cd94/nkg2a is an inhibitory receptor expressed by natural killer (nk) cells and a subset of cd8+ t cells. ligation of cd94/nkg2a by its ligand hla-e results in tyrosine phosphorylation of the nkg2a immunoreceptor tyrosine-based inhibitory motifs, and recruitment and activation of the sh2 domain-bearing tyrosine phosphatase-1, which in turn suppresses activation signals. the nkg2a gene encodes two isoforms, nkg2a and nkg2b, with the latter lacking the stem region. we identified three new alternat ... | 2006 | 16237464 |
| neoadjuvant chemotherapy in transitional-cell carcinoma of the bladder. | neoadjuvant chemotherapy in transitional-cell carcinoma of the bladder (tcc) improves survival. this is one of the most important developments in the management of muscle-invasive bladder cancer in recent times. there is an improved absolute 5-year survival of at least 5% for t2-t4 disease. to achieve this benefit, a cisplatin-containing combination is required. there is no difference in survival whether radical radiotherapy or radical cystectomy is given as subsequent definitive treatment. | 2005 | 16238137 |
| symmetry of the nose after presurgical nasoalveolar molding in infants with unilateral cleft lip and palate: a preliminary study. | to assess nostril symmetry and alveolar cleft width in infants with unilateral cleft lip and palate following presurgical nasoalveolar molding (nam). | 2005 | 16241178 |
| specific heat of a fermionic atomic cloud in the unitary regime. | in the unitary regime, when the scattering amplitude greatly exceeds in magnitude the average interparticle separation, and below the critical temperature thermal properties of an atomic fermionic cloud are governed by the collective modes, specifically the bogoliubov-anderson sound modes. the specific heat of an atomic cloud in an elongated trap, in particular, has a rather complex temperature dependence, which changes from an exponential behavior at very low temperatures (t << h omega(parallel ... | 2005 | 16241633 |
| preoperative radiation with concurrent chemotherapy for resectable rectal cancer: effect of dose escalation on pathologic complete response, local recurrence-free survival, disease-free survival, and overall survival. | three phase ii studies of preoperative radiotherapy and concurrent 5fu chemotherapy were undertaken. the primary endpoints were acute toxicity and pathologic complete response rate (pcr). secondary endpoints were local recurrence-free survival (lrfs), disease-free survival (dfs), and overall survival (os). | 2006 | 16242252 |
| treatment with rhenium-188-perrhenate and iodine-131 of nis-expressing mammary cancer in a mouse model remarkably inhibited tumor growth. | novel therapeutic modalities are needed for breast cancer patients in whom standard treatments are not effective. mammary gland sodium/iodide symporter has been identified as a molecular target in breast cancers in humans and in some transgenic mouse models. we report the results of a therapy study with (131)i(-) and (188)reo(4)(-) of breast cancer in polyoma middle t oncoprotein (pymt) transgenic mice endogenously expressing the na(+)/i(-) symporter (nis). | 2005 | 16243644 |
| clinical features of hepatocellular carcinoma with extrahepatic metastases. | there are few detailed clinical reports about extrahepatic metastases of hepatocellular carcinoma (hcc). the purpose of the present study was to elucidate the clinical features of extrahepatic metastases of hcc. | 2005 | 16246200 |
| surgical approaches to the cervico-thoracic junction. | the cervico-thoracic junction (ctj) extends between the 7th cervical and the 4th thoracic vertebrae and comprehends the inferior portion of the brachial plexus and the parenchymatous, vascular and nervous structures of the upper mediastinum. the posterior surgical approaches, as the laminectomy or the arthro-pediclectomy, fail to expose the anterior spinal elements. thus, further surgical approaches have been proposed: postero-lateral, antero-lateral (thoracotomies) and purely anterior. the aim ... | 2005 | 16247344 |
| antiviral activity of steric-block oligonucleotides targeting the hiv-1 trans-activation response and packaging signal stem-loop rnas. | mixmer oligonucleotides consisting of residues of both 2'-o-methylnucleosides (ome) and locked nucleic acids (lna) were designed targeting two stem-loops in the 5'-utr of hiv-1 rna, the transactivation response region (tar), which is the site of binding of the tat protein, and the sl3 loop, which is the primary packaging element that binds the gag polyprotein. these oligonucleotides were found to inhibit syncitia formation dose- and sequence-dependently when delivered to hela t4 ltr beta-gal cel ... | 2005 | 16247957 |
| synthesis and characterization of dna duplexes containing an n3t-ethyl-n3t interstrand crosslink in opposite orientations. | dna duplexes containing an ethyl interstrand crosslink that bridges the n3 atoms of thymidines on the opposite strands have been synthesized using an approach that combines conventional solid phase oligonucleotide synthesis and the selective removal of protecting groups of a crosslinked thymidine dimer. this approach allows for the assembly of a crosslinked duplex directly on the solid support. duplexes that contain a n3t-ethyl-n3t interstrand crosslink in a staggered orientation at either a -ta ... | 2005 | 16248073 |
| [the role of neoadjuvant therapy in the treatment of locally advanced, stage iii non-small-cell lung cancer]. | to review the progress achieved in the neoadjuvant treatment of patients with locally advanced nsclc by evaluating the articles published during the last 10 years. | 2005 | 16249813 |
| optimizing splinted ligation of highly structured small rnas. | the synthesis of highly structured small rnas containing nonstandard nucleotides is of high interest for structural and functional investigations. a general approach is the joining, by t4 dna ligase-mediated splinted ligation, of two or more rna fragments, each of which may contain its own set of modified nucleotides. the rna fragments hybridize with a complementary dna splint to form a ternary ligation-competent-complex (lcc), which is then turned over by the dna ligase. we studied the formatio ... | 2005 | 16251384 |
| psychological distress and the impact of social support on fathers and mothers of pediatric cancer patients: long-term prospective results. | to explore the effects of social support on psychological distress of parents of pediatric cancer patients using a prospective design over a 5-year period. | 2006 | 16251479 |
| hypobaric spinal anesthesia with 0.2% tetracaine for total joint hip arthroplasy. | hypobaric local anesthetics for total hip replacement (thr) have potential advantages related to body position and differential block. however, the dose requirements of hypobaric local anesthetics for thr have not been clearly established. therefore, we undertook a dose-response study of hypobaric tetracaine for thr. | 2005 | 16251562 |
| thyroid autoimmunity, depression and anxiety; are there any connections? an epidemiological study of a large population. | the aim of the study was to examine the relationship between antithyroid antibodies, depression, and anxiety in a large population. | 2005 | 16253615 |
| elevation of serum adiponectin levels in basedow disease. | the present study was undertaken to determine whether thyroid hormone affects serum adiponectin levels in the patients with basedow disease. sixty-four patients with basedow disease were examined; 32 patients had hyperthyroid state and 32 patients had euthyroid state who had been treated with antithyroid drugs. in addition, 30 age- and sex-matched subjects served as a control. serum adiponectin, free t4, free t3, thyroid-stimulating hormone, and thyroid-stimulating hormone receptor antibody (tra ... | 2005 | 16253634 |
| the t4 syndrome. | | 2005 | 16253863 |
| basal metabolic rate and thyroid hormones of late-middle-aged and older human subjects: the zenith study. | this paper describes baseline data on basal metabolic rate (bmr), thyroid hormone levels and body composition of middle-aged and older people participating in the zenith project and the correlation of thyroid hormone levels with zinc status. | 2005 | 16254583 |
| activation of adenosine a(1) receptors alters behavioral and biochemical parameters in hyperthyroid rats. | adenosine acting on a(1) receptors has been related with neuroprotective and neuromodulatory actions, protection against oxidative stress and decrease of anxiety and nociceptive signaling. previous studies demonstrated an inhibition of the enzymes that hydrolyze atp to adenosine in the rat central nervous system after hyperthyroidism induction. manifestations of hyperthyroidism include increased anxiety, nervousness, high o(2) consumption and physical hyperactivity. here, we investigated the eff ... | 2006 | 16257062 |
| effects of megestrol acetate on pituitary function and end-organ hormone secretion: a post hoc analysis of serum samples from a 12-week study in healthy older men. | megestrol acetate (ma) is a synthetic progestin commonly used to promote weight gain in malnourished older individuals. in small studies, ma administration has been associated with reduced serum cortisol concentrations in patients with cancer or aids. the impact of ma on the pituitary secretion of adrenocorticotropic hormone (acth) and other hormones is unclear, and the prevalence and extent of hypocortisolemia in older individuals after ma treatment is unknown. a randomized, placebo-controlled ... | 2005 | 16257818 |
| segh and hef: two novel homing endonucleases whose genes replace the mobc and mobe genes in several t4-related phages. | t4 contains two groups of genes with similarity to homing endonucleases, the seg-genes (similarity to endonucleases encoded by group i introns) containing giy-yig motifs and the mob-genes (similarity to mobile endonucleases) containing h-n-h motifs. the four seg-genes characterized to date encode homing endonucleases with cleavage sites close to their respective gene loci while none of the mob-genes have been shown to cleave dna. of 18 phages screened, only t4 was found to have mobc while mobe g ... | 2005 | 16257983 |
| functional analysis of the bacteriophage t4 dna-packaging atpase motor. | packaging of double-stranded dna into bacteriophage capsids is driven by one of the most powerful force-generating motors reported to date. the phage t4 motor is constituted by gene product 16 (gp16) (18 kda; small terminase), gp17 (70 kda; large terminase), and gp20 (61 kda; dodecameric portal). extensive sequence alignments revealed that numerous phage and viral large terminases encode a common walker-b motif in the n-terminal atpase domain. the gp17 motif consists of a highly conserved aspart ... | 2006 | 16258174 |
| pathological distribution of positive lymph nodes in patients with clinically and radiologically n0 oropharyngeal carcinoma: implications for imrt treatment planning. | we identified involved lymph node groups in patients with oropharyngeal carcinoma and radiologically n0 disease, aiming to define the clinical target volume, and to assess the negative predictive value of ct neck and correlate it to the tumor site, stage, and grade. | 2005 | 16259872 |
| [changes in hemodynamics and nitric oxide/endothelin-1 during liver transplantation in patients with cirrhosis]. | to study the systemic and pulmonary hemodynamic changes of patients with cirrhosis during liver transplantation and evaluate the role of nitric oxide (no) and endothelin-1(et-1). | 2005 | 16259914 |