| the prognostic significance of p53, p27 kip1, p21 waf1, her-2/neu, and ki67 proteins expression in gastric cancer: a clinicopathological and immunohistochemical study of 121 arab patients. | the variability of prognosis within a pathological stage of gastric cancer (gc) at presentation, underscores the need for specific biological markers to identify subgroups of patients with aggressive course for intensive treatment. to our knowledge, this is the first study from an arab population reporting on the relationship of p53, p27 kip1, p21 waf1, her-2/neu, and ki67 expression, and clinicopathological features and their prognostic significance. | 2005 | 16121348 |
| [prevalence of latent and manifest hyperthyroidism in an iodine-deficient area: non-selected patient population admitted for ct studies with iodine-containing contrast agents]. | to evaluate the prevalence of latent and manifest hyperthyroidism in a non-selected group of patients admitted for contrast enhanced ct studies blood samples were tested for the levels of thyroid-stimulating hormone (tsh). | 2005 | 16123871 |
| [ultrasound of hypopharyngeal and oesophageal cancer: possibilities and limitations to staging and planning of therapy]. | sonographic examination of the hypopharynx and the extrathoracic oesophagus can be difficult. therefore, most surgeons prefer to utilise ct or mri scanning. surgery is planned on the basis of endoscopic findings combined with radiologic information. the aim of the present prospective study was to demonstrate that the combination of ultrasonography and endoscopy provides a sufficient basis for the planning of surgical interventions in patients suffering from hypopharyngeal cancer or cancer of the ... | 2005 | 16123926 |
| structure of the central hub of bacteriophage mu baseplate determined by x-ray crystallography of gp44. | bacteriophage mu is a double-stranded dna phage that consists of an icosahedral head, a contractile tail with baseplate and six tail fibers, similar to the well-studied t-even phages. the baseplate of bacteriophage mu, which recognizes and attaches to a host cell during infection, consists of at least eight different proteins. the baseplate protein, gp44, is essential for bacteriophage mu assembly and the generation of viable phages. to investigate the role of gp44 in baseplate assembly and infe ... | 2005 | 16125724 |
| usefulness of the 2nd generation assay for anti-tsh receptor antibodies to differentiate relapse of graves' thyrotoxicosis from development of painless thyroiditis after antithyroid drug treatment for graves' disease. | after antithyroid drug (atd) treatment for graves' disease, either a relapse of graves' thyrotoxicosis or painless thyroiditis can develop. it is important to differentiate these two types of thyrotoxicosis because of the difference in required therapy. however, differentiation of thyrotoxicosis is usually difficult without radioactive iodine uptake (raiu) which is not available in general practice. we investigated the clinical usefulness of the 2nd generation assay for anti-tsh receptor antibod ... | 2005 | 16127219 |
| type 2 iodothyronine deiodinase is the major source of plasma t3 in euthyroid humans. | the relative roles of the types 1 and 2 iodothyronine deiodinases (d1 and d2) in extrathyroidal 3,5,3'-triiodothyronine (t3) production in humans are unknown. we calculated the rate of thyroxine (t4) to t3 conversion by intact cells transiently expressing d1 or d2 at low (2 pm), normal (20 pm), and high (200 pm) free t4 concentrations. deiodinase activities were then assayed in cell sonicates. the ratio of t3 production in cell sonicates (catalytic efficiency) was multiplied by the tissue activi ... | 2005 | 16127464 |
| [neoajuvant polychemotherapy at the complex treatment of the patients with laryngeal cancer]. | the treatment of 131 patients with t3.4n0m0 laryngeal cancer was performed by radiation and chemoradiation methods. the efficacy was evaluated of by absence of recurrence, by failure incidence and by survival rate. of 131 patients investigated 90 had radiation therapy and 41 - chemoradiation treatment with induction polychemotherapy with cisplatin and 5-fluorouracil. among the patients with t3n0m0 laryngeal cancer (n=65) and t4n0m0 (n=25) after radiation therapy 25(38.5 per cent) patients with t ... | 2002 | 16127903 |
| risk-group definition by recursive partitioning analysis of patients with squamous cell head and neck carcinoma treated with surgery and postoperative radiotherapy. | the objective of this study was to define different prognostic groups with regard to locoregional control (lrc) derived from recursive partitioning analysis (rpa). | 2005 | 16130134 |
| breast carcinoma with noninflammatory skin involvement (t4b): time to abandon an historic relic from the tnm classification. | in this study, the authors evaluated the clinical presentation of patients with t4b breast carcinoma, analyzed the impact of noninflammatory skin involvement on long-term survival, and addressed the question whether the t4 tumor category still has any justification. | 2005 | 16130140 |
| role of cd97(stalk) and cd55 as molecular markers for prognosis and therapy of gastric carcinoma patients. | to explore the mechanism of development and aggressiveness in gastric carcinomas by investigating the expression and role of cd97 and its cellular ligand cd55 in gastric carcinomas. | 2005 | 16130195 |
| cellular and structural biology of the deiodinases. | the three iodothyronine deiodinases catalyze the initiation (d1, d2) and termination (d3) of thyroid hormone effects in vertebrates. a recently conceived three-dimensional model predicts that these enzymes share a similar structural organization and belong to the thioredoxin (trx) fold superfamily. their active center is a selenocysteine- containing pocket defined by the beta1-alpha1-beta2 motifs of the trx fold and a domain that shares strong similarities with the active site of iduronidase, a ... | 2005 | 16131321 |
| the role of deiodinases in amphibian metamorphosis. | valerie galton's prediction over 40 years ago that deiodinases would be important in amphibian metamorphosis has been confirmed. expression of iodothyronine deiodinase type 2 (d2) and type 3 (d3) occurs in embryogenesis at relevant locations long before the thyroid gland has developed. the expression of d2, an enzyme that synthesizes the active hormone triiodothyronine (t3) from its circulating precursor thyroxine (t4), accurately marks cells at the time that they undergo thyroid hormone-depende ... | 2005 | 16131324 |
| reversible diastolic dysfunction after long-term exogenous subclinical hyperthyroidism: a randomized, placebo-controlled study. | subclinical hyperthyroidism has been reported to affect systolic and diastolic cardiac function. however, the reversibility of these effects is not well established. | 2005 | 16131580 |
| inhibition of pituitary type 2 deiodinase by reverse triiodothyronine does not alter thyroxine-induced inhibition of thyrotropin secretion in hypothyroid rats. | intrapituitary triiodothyronine (t3) production plays a pivotal role in the control of tsh secretion. its production is increased in the presence of decreased serum thyroxine (t4) concentrations and the enzyme responsible, deiodinase type 2 (d2), is highest in hypothyroidism. in order to document the role of this enzyme in adult rats we developed an experimental model that inhibited this enzyme using the specific inhibitor, reverse t3 (rt3). | 2005 | 16131606 |
| plasma ghrelin in anorexia, bulimia, and binge-eating disorder: relations with eating patterns and circulating concentrations of cortisol and thyroid hormones. | the present study was designed to investigate the relations between plasma ghrelin concentrations, eating patterns, and circulating concentrations of cortisol and thyroid hormones in women with anorexia nervosa, bulimia nervosa, and binge-eating disorder. the patterns of disordered eating behavior were assessed using the eating attitudes test (eat-26) and the bulimia test-revised (bulit-r). in women with eating disorders, but not in healthy control women, plasma ghrelin concentrations were negat ... | 2005 | 16131812 |
| [vertebral body replacement with synex in combined posteroanterior surgery for treatment of thoracolumbar injuries]. | reduction and stabilization of unstable spinal injuries with reconstruction of the anterior column resulting in a permanent restitution of the physiologic spinal alignment, stability and load-bearing capacity. | 2005 | 16132250 |
| optimal ligation level of the primary feeding artery and bowel resection margin in colon cancer surgery: the influence of the site of the primary feeding artery. | in colon cancer surgery, it is recommended that en bloc resection involving extended lymphadenectomy, characterized as a hemicolectomy, be performed by ligating the primary feeding artery at a high position and resecting proximal and distal with 5-cm to 10-cm bowel margins. however, there is little evidence to unequivocally support such extensive lymphovascular resection. | 2005 | 16132477 |
| incidence and clinical impact of sterilized disease and minimal residual disease after preoperative radiochemotherapy for rectal cancer. | in advanced rectal cancer, chemoradiation can induce downstaging until complete disappearance of the tumor or its persistence in minimal form. the complete sterilized and the minimal residual disease often are considered similar. we evaluated the specific incidence of these two conditions and analyzed their impact in terms of local recurrence, distant metastasis, and survival. | 2005 | 16132481 |
| [endosonographic imaging of tumor thickness in oral squamous cell cancer and its effect on the incidence of lymph node metastases]. | the correlation between increasing tumor thickness and lymph node metastases as well as reduced survival in oral cancer has been proven by several studies. in most investigations the tumor thickness was assessed in histological sections. the aim of our prospective study was to assess tumor thickness in oral squamous cell carcinoma (oscc) by intraoral ultrasonography and to evaluate the predictive value of tumor thickness for incidence of cervical lymph node involvement and survival. | 2005 | 16133281 |
| functional characterization of delta9 and omega9 desaturase genes in mortierella alpina 1s-4 and its derivative mutants. | cloning and characterization of the delta9 desaturase (delta9i) gene of a fungus, mortierella alpina 1s-4, was previously reported. in this study, two genes encoding delta9 desaturase homologs were isolated from this fungus. one is a delta9 desaturase (delta9ii) that exhibits 86% amino acid sequence similarity to delta9i. functional analysis involving expression of the encoding gene in aspergillus oryzae revealed that delta9ii exhibits delta9 desaturase activity, 18:0 being converted to 18:1delt ... | 2006 | 16133334 |
| randomized controlled trial of an educational intervention for managing fatigue in women receiving adjuvant chemotherapy for early-stage breast cancer. | to evaluate the efficacy of a psychoeducational intervention in improving cancer-related fatigue. | 2005 | 16135471 |
| ultrastructural changes in rat livers perfused in vitro and in vivo with a high dose of methotrexate. | methotrexate is an antifolate that is widely used in the treatment of malignant tumours and other diseases. the present study was undertaken to examine the short-term effects of high doses of methotrexate (hd-mtx) on the ultrastructure and metabolic activity of isolated rat livers. the authenticity of the drug-induced changes was substantiated by the concomitant use of in vivo experiments. isolated rat livers were infused with hd-mtx via the portal vein for 3 hours (total dose for each liver 200 ... | 2005 | 16136496 |
| a rational approach to pulmonary screening in newly diagnosed head and neck cancer. | the purpose of this study was to determine the detection rate of lung metastasis or a synchronous lung primary tumor in patients with newly diagnosed head and neck mucosal squamous cell carcinoma (scc) and to determine factors that are associated with positive findings. | 2005 | 16136584 |
| clinical investigation: thyroid function test abnormalities in cardiac arrest associated with acute coronary syndrome. | it is known that thyroid homeostasis is altered during the acute phase of cardiac arrest. however, it is not clear under what conditions, how and for how long these alterations occur. in the present study we examined thyroid function tests (tfts) in the acute phase of cardiac arrest caused by acute coronary syndrome (acs) and at the end of the first 2 months after the event. | 2005 | 16137355 |
| assessment of serum catecholamine concentrations in patients with pheochromocytoma undergoing videolaparoscopic adrenalectomy. | we analyzed the changes in serum catecholamine concentrations, i.e. adrenaline and noradrenaline, in response to surgical stress in patients with pheochromocytoma who undergone videolaparoscopic adrenalectomy. | 2005 | 16137397 |
| a modified cdna subtraction to identify differentially expressed genes from plants with universal application to other eukaryotes. | we have designed a simple and efficient polymerase chain reaction (pcr)-based cdna subtraction protocol for high-throughput cloning of differentially expressed genes from plants that can be applied to any experimental system and as an alternative to dna chip technology. sequence-independent pcr-amplifiable first-strand cdna population was synthesized by priming oligo-dt primer with a defined 5' heel sequence and ligating another specified single-stranded oligonucleotide primer on the 3' ends of ... | 2005 | 16137632 |
| clinical and epidemiological features of oral cancer in a medical school teaching hospital from 1994 to 2002: increasing incidence in women, predominance of advanced local disease, and low incidence of neck metastases. | description of clinical and epidemiological characteristics of patients who underwent surgery for oral cancer in a medical school teaching hospital, and determination of differences with respect to other institutions and/or periods of time. | 2005 | 16138235 |
| development of metamorphosis assay using silurana tropicalis for the detection of thyroid system-disrupting chemicals. | the west african clawed frog (silurana tropicalis), which resembles the south african clawed frog (xenopus laevis), but is somewhat smaller, has a diploid genome and a shorter generation time. therefore, s. tropicalis has the potential for use as a new model in ecotoxicology. we demonstrated a s. tropicalis metamorphosis assay based on xenopus metamorphosis assay (xema) using 1 microg/l thyroxine (t4) and 75 mg/l propylthiouracil (ptu). tadpoles at developmental stages 48-50 were exposed to chem ... | 2006 | 16139362 |
| bladder cancer with obstructive uremia: oncologic outcome after definitive surgical management. | to report the surgical and oncologic outcomes of patients with bladder cancer who present with obstructive uremia. | 2005 | 16140072 |
| regulation of iodothyronine deiodinase and roles of thyroid hormones in human coronary artery smooth muscle cells. | thyroid hormones have been reported to have significant effects on the peripheral vascular system, including relaxation of vascular smooth muscle cells and prevention of atherosclerosis. to exert its biological activity, thyroxine (t4) needs to be converted to 3,5,3'-triiodothyronine (t3) by type 1 and type 2 iodothyronine deiodinases. we have previously identified type 2 iodothyronine deiodinase (d2) expression in cultured human coronary artery smooth muscle cells (hcasmcs). in the present stud ... | 2006 | 16140305 |
| methylmercury inhibits type ii 5'-deiodinase activity in nb41a3 neuroblastoma cells. | methylmercury (mehg) is a well-known neurotoxicant and prenatal exposure to mehg results in severe brain damage. since mehg has a high affinity for thiol groups, we sought to determine whether mehg inhibited type ii iodothyronine deiodinase (d2) activity, by which prohormone thyroxine (t4) is converted to active thyroid hormone, 3,5,3'-triiodothyronine (t3) in the brain, using nb41a3 mouse neuroblastoma cells. in mehg-treated cells, d2 activity was inhibited in a dose- and time-dependent manner; ... | 2006 | 16140479 |
| adiponectin, leptin and thyroid hormones in patients with chronic renal failure and on renal replacement therapy: are they related? | renal function affects thyroid function and adipocytokines in many ways. we aimed to assess the adipocytokines adiponectin and leptin in relation to thyroid function in patients with chronic renal failure treated conservatively, in haemodialysed patients and in kidney allograft recipients. | 2006 | 16141459 |
| a four-dimensional structure of t4 infection. | | 2005 | 16142226 |
| therapeutic efficacy of zinc sulphate used in clustered model treatment in alleviating zinc deficiency in cattle and its effect on hormones, vitamins and production parameters. | a survey was conducted in 10 districts of northern india. significant deficiency of zinc was observed in soil, fodders and (cattle) serum samples. the animals showed typical signs of zinc deficiency, namely stiff gait, swelling of hocks and knees, subcutaneous fluid accumulation, rough coat, etc. of variable intensity. a clustered model therapeutic trial was conducted and zinc-deficient cattle were divided into three groups. group a was provided with mineral mixture containing zinc sulphate. gro ... | 2005 | 16142608 |
| polyarticular corticosteroid injection versus systemic administration in treatment of rheumatoid arthritis patients: a randomized controlled study. | to study the effectiveness and side effects of polyarticular corticosteroid injection compared to systemic administration in patients with rheumatoid arthritis (ra), and to examine the differential response to injection among joints. | 2005 | 16142862 |
| gene profiling involved in immature cd4+ t lymphocyte responsible for systemic lupus erythematosus. | we attempted to characterize the genes expression of cd4+ t lymphocytes for the pathogenesis of systemic lupus erythematosus (sle). genomewide gene expression profiles of cd4+ t cells, which were isolated from the disease severe activity (t4-1s) and nonactivity (t4-2s) with an sle patient by using long serial analysis of gene expression (longsage). we picked out 289 genes matching to unigene cluster with different expression more than four copies between t4-1s and t4-2s libraries and analyzed th ... | 2006 | 16143398 |
| is dissection of level iv absolutely necessary in elective lateral neck dissection for clinically n0 laryngeal carcinoma? | a prospective study of 73 previous untreated consecutive patients with clinically n0 laryngeal squamous cell carcinoma (scc) from january 1997 to october 2002 was undertaken to determine whether level iv lymph nodes can be saved in elective lateral neck dissection (lnd) performed as a treatment for the n0 neck. the incidence of pathological metastases to level iv lymph nodes was evaluated, as were the incidence of regional recurrence after elective lnd, and postoperative complications such as ch ... | 2006 | 16143563 |
| enhanced neurally evoked responses and inhibition of norepinephrine reuptake in rat mesenteric arteries after spinal transection. | in patients with high thoracic spinal lesions that remove most of the central drive to splanchnic preganglionic neurons, visceral or nociceptive stimuli below the lesion can provoke large increases in blood pressure (autonomic dysreflexia). we have examined the effects of t4 spinal transection on isometric contractions of mesenteric arteries isolated from spinalized rats. nerve-evoked contractions involved synergistic roles for norepinephrine and atp. at 7 wk after spinal transection, responses ... | 2006 | 16143650 |
| factors influencing the synonymous codon and amino acid usage bias in at-rich pseudomonas aeruginosa phage phikz. | to reveal how the at-rich genome of bacteriophage phikz has been shaped in order to carry out its growth in the gc-rich host pseudomonas aeruginosa, synonymous codon and amino acid usage bias of phikz was investigated and the data were compared with that of p. aeruginosa. it was found that synonymous codon and amino acid usage of phikz was distinct from that of p. aeruginosa. in contrast to p. aeruginosa, the third codon position of the synonymous codons of phikz carries mostly a or t base; codo ... | 2005 | 16143818 |
| [surgical therapy of subglottic carcinoma]. | to analyze the clinical characteristics, surgical procedures and correlated prognostic factors of the cases with subglottic carcinoma; to seek for the optimal surgical treatment for the patients suffering from subglottic carcinoma. | 2005 | 16144333 |
| [supracricoid partial laryngectomy for the treatment of laryngeal cancer]. | to evaluate the oncological and functional outcomes in patients undergoing supracricoid partial laryngectomy (scpl). | 2005 | 16144335 |
| polymorphisms in type 2 deiodinase are not associated with well-being, neurocognitive functioning, and preference for combined thyroxine/3,5,3'-triiodothyronine therapy. | some patients on levothyroxine replacement display significant impairment in psychological well-being, compared with sex- and age-matched controls. levothyroxine-treated patients can be assumed to derive t3 exclusively from deiodination of t4, which, in the central nervous system, is regulated by type ii deiodinase (dii). | 2005 | 16144953 |
| [effects of ulinastatin on erythrocyte lipid peroxidation in patients undergoing open heart surgery]. | to investigate the effects of ulinastatin on erythrocyte lipid peroxidation in patients undergoing open heart surgery. | 2004 | 16145909 |
| [autopsy case of lewy body dementia associated with abundant argyrophilic grains]. | we report an autopsy case showing neuropathologically abundant lewy bodies and argyrophilic grains. a japanese woman without hereditary burden developed parkinsonian gait at the age of 74, following by insomnia, memory disturbance, delirium, resting tremor, rigidity, and retropulsion. about 8 months later, a visual hallucination, concerning small worms, children, and so on, became obvious. about 16 months later, malignant lymphoma was detected. about 17 months later, she died of pneumonia. the t ... | 2005 | 16146214 |
| thoracic epidural anesthesia (tea) with 0.2% ropivacaine in combination with ipsilateral brachial plexus block (bpb) for modified radical mastectomy (mrm). | breast cancer is the 2nd most common tumors in thai women. until now, oncologic breast surgeries are typically performed by general anesthesia (ga). however, ga cannot provide adequate postoperative pain control and routine use of parenteral opioids aggravate postoperative sedation, nausea, emesis, impaired oxygenation and depressed ventilation. thoracic epidural anesthesia (tea) is one of the regional anesthetic techniques that can be done by using a low dose of local anesthetic in combination ... | 2005 | 16146257 |
| current methodology to assess bioequivalence of levothyroxine sodium products is inadequate. | levothyroxine sodium is a drug with a narrow therapeutic index for which an individual patient must have his or her dose carefully titrated to achieve the necessary therapeutic effect. in addition, exogenous levothyroxine cannot be distinguished from the endogenously produced hormone. since 2004, generic formulations have been approved for the most frequently prescribed brands of levothyroxine sodium. this review examines the methodology and statistical acceptance criteria and summarizes finding ... | 2005 | 16146348 |
| management of contralateral n0 neck in tonsillar squamous cell carcinoma. | it is well established that tonsillar squamous cell carcinomas have a high probability of disseminating to the neck. an ipsilateral neck treatment is mandatory during initial treatment of stages ii to iv tonsillar carcinomas. however, as of yet, no consensus exists whether to perform elective contralateral neck management. | 2005 | 16148715 |
| the reliability of lymph-node staging in rectal cancer after preoperative chemoradiotherapy. | to determine the prognostic significance of the nodal stage and number of nodes recovered in the surgical specimen after preoperative synchronous chemoradiation (scrt) and surgery for locally advanced or unresectable rectal cancer. | 2005 | 16149289 |
| [total thyroxine (t4), free thyroxine (ft4)]. | | 2005 | 16149503 |
| [the effect of a single electroconvulsive shock on pituitary-thyroid-adrenal-gonadal axis function in men with severe depression--preliminary report]. | electroconvulsive therapy (ect) is an effective treatment of severe depression but its mechanism of action is still unknown. the aim of the study was to investigate the effect of first ect on serum hormone concentrations in patients with severe depression. | 2005 | 16149757 |
| extract of lycopus europaeus l. reduces cardiac signs of hyperthyroidism in rats. | extracts from the plant lycopus europaeus l. are traditionally used in mild forms of hyperthyroidism. high doses caused a reduction of tsh or thyroid hormone levels in animal experiments, whereas in hyperthyroid patients treated with low doses of lycopus an improvement of cardiac symptoms was reported without major changes in tsh or thyroid hormone concentrations. lycopus extract was tested in thyroxine treated hyperthyroid rats (0.7 mg/kg bw i.p.). co-treatment with an hydroethanolic extract fr ... | 2006 | 16150466 |
| thyroid epithelial cell hyperplasia in ifn-gamma deficient nod.h-2h4 mice. | the role of inflammatory cells in thyroid epithelial cell (thyrocyte) hyperplasia is unknown. here, we demonstrate that thyrocyte hyperplasia in ifn-gamma-/- nod.h-2h4 mice has an autoimmune basis. after chronic exposure to increased dietary iodine, 60% of ifn-gamma-/- mice had severe thyrocyte hyperplasia with minimal or moderate lymphocyte infiltration, and thyroid dysfunction with reduced serum t4. all mice produced anti-thyroglobulin autoantibody. some wild-type nod.h-2h4 mice had isolated a ... | 2006 | 16150647 |
| thyroid hormone deiodinases revisited: insights from lungfish: a review. | in vertebrates, hormones released from the thyroid gland travel in the circulation to target tissues where they may be processed by deiodinating enzymes into more active or inactive iodothyronines. in mammals, there are three deiodinating enzymes described. type1 (d1), which primarily occurs in the liver, converts reverse t3 into t2 for clearance. it also converts t4 into t3. this production of t3 is believed to contribute to the bulk of circulating t3 in mammals. the type2 (d2) enzyme may be fo ... | 2006 | 16151818 |
| effect of sub-acute oral cyanide administration in rats: protective efficacy of alpha-ketoglutarate and sodium thiosulfate. | chronic toxicity of cyanide in humans and animals has been previously described. alpha-ketoglutarate (alpha-kg) and sodium thiosulfate (sts) are known to confer remarkable protection against acute cyanide poisoning in rodents. their efficacy against sub-acute or chronic cyanide exposure is not known. the objective of the present study was to assess the sub-acute toxicity of potassium cyanide (kcn) in female rats following oral administration of 7.0 mg/kg (0.5 ld50) for 14 d. the effect of alpha- ... | 2005 | 16154552 |
| thyroid hormone regulation of cell migration and oxidative metabolism in polymorphonuclear leukocytes: clinical evidence in thyroidectomized subjects on thyroxine replacement therapy. | migration and superoxide anion (o2-) generation were studied in polymorphonuclear leukocytes (pmns) from 14 athyreotic patients, previously treated by total thyroidectomy and radioiodine therapy for differentiated thyroid carcinoma, and from age- and sex-matched euthyroid healthy controls. patients were studied twice: in hypothyroidism (visit 1) and after tsh-suppressive l-t4 replacement therapy (visit 2). random migration and n-formyl-met-leu-phe (fmlp) 0.1-microm induced chemotaxis were simila ... | 2006 | 16154598 |
| intensity-modulated radiation therapy for the treatment of nonanaplastic thyroid cancer. | intensity-modulated radiation therapy (imrt) enables highly conformal treatment for thyroid cancer (tc). in this study, we review outcomes/toxicity in a series of tc patients treated with imrt. | 2005 | 16154712 |
| [breast cancers associated with pregnancy. about two cases]. | the association between breast cancer and pregnancy is a rare but not exceptional. the authors reports two cases of patients aged 29 and 30 years respectively. both patients had single pregnancis. the first patient, third delivery, had a gestational age of 30 weeks of amenorrhea and a stadify t 3nim0. the second patent was second delivery and had during her first prenatal consultation at 38 weeks of amenorrhea a developing but not extending statify t4. cytology suggest the diagnosis whicle was c ... | 2005 | 16156417 |
| activity-based in vitro selection of t4 dna ligase. | recent in vitro methodologies for selection and directed evolution of proteins have concentrated not only on proteins with affinity such as single-chain antibody but also on enzymes. we developed a display technology for selection of t4 dna ligase on ribosome because an in vitro selection method for dna ligase had never been developed. the 3' end of mrna encoding the gene of active or inactive t4 dna ligase-spacer peptide fusion protein was hybridized to dsdna fragments with cohesive ends, the s ... | 2005 | 16157309 |
| response of ch4 emission of paddy fields to land management practices at a microcosmic cultivation scale in china. | the terrestrial ecosystem may be either a source or a sink of ch4 in rice paddies, depending, to a great extent, on the change of ecosystem types and land use patterns. ch4 emission fluxes from paddy fields under 4 cultivation patterns (conventional plain culture of rice (t1), no-tillage and ridge culture of rice (t2), no-tillage and ridge culture of rice and wheat (t3), and rice-wheat rotation (t4)) were measured with the closed chamber technique in 1996 and 1998 in chongqing, china. the result ... | 2005 | 16158607 |
| [quality of life in patients after radical prostatectomy]. | according to the literature, after radical prostatectomy the patients had normal micturition and erectile function in 50 and 10-30%, respectively. a total of 647 patients with diagnosis prostatic cancer (pc) stage t1a-t4 were examined in two clinics in 1997-2003. of them, 43 patients (pc stage t1a-t3a) have undergone retropubic radical prostatectomy (rrp) by a modified nerve-preserving technique (preservation of the urinary bladder neck, puboprostatic joints in prostate size > 60 cm). preoperati ... | 2005 | 16158742 |
| p53 expression in small cell carcinoma of the urinary bladder: biological and prognostic implications. | small cell carcinoma of the urinary bladder is a rare and highly aggressive tumor. p53 expression has been shown to be associated with poor prognosis in a variety of tumors. this study was undertaken to investigate p53 expression in a large series of small cell carcinomas of the urinary bladder and to correlate the findings with clinicopathologic parameters and clinical outcome. pathologic findings were reviewed and were correlated with clinical findings and follow-up information. immunohistoche ... | 2005 | 16158936 |
| [expression and clinical significance of cd1a+ dendritic cells in glottic squamous cell carcinoma]. | dendritic cells (dcs) are the most important antigen-presenting cells. cd1a, a marker of immature dcs, plays a role in tumorigenesis. this study was designed to explore the correlation of cd1a(+) dcs to pathologic degree, t stage, local recurrence, and prognosis of glottic squamous cell carcinoma. | 2005 | 16159438 |
| pcdds, pcdfs, and coplanar pcbs in wild terrestrial mammals from japan: congener specific accumulation and hepatic sequestration. | the present study determined the contamination levels and congener-specific accumulation features of dioxins and related compounds (drcs) in wild terrestrial mammals such as large japanese field mice (ljfm), lesser japanese moles (ljms), and raccoon dogs (rds) collected from kanto region in japan during 2001. the toxic equivalent quantity (teq) levels in the carcasses or adipose tissues were in the order of rds > or = ljms > ljfm. comparison of drc congener profiles in the three species and prin ... | 2006 | 16159690 |
| synthesis of thyroid hormone binding proteins transthyretin and albumin by human trophoblast. | mechanisms regulating materno-fetal transfer of thyroid hormone are not well understood. modulation of trophoblast type 3 iodothyronine deiodinase (d3) may play an important role. | 2005 | 16159939 |
| a new concurrent chemotherapy with vinorelbine and mitomycin c in combination with radiotherapy in patients with locally advanced squamous cell carcinoma of the head and neck. | the purpose of this pilot study was to evaluate the feasibility and toxicity of concurrent chemotherapy with vinorelbine and mitomycin c in combination with accelerated radiotherapy (rt) in patients with locally advanced cancer of the head and neck. | 2005 | 16160398 |
| effects of fentin hydroxide on reproduction of the japanese quail (coturnix coturnix japonica). | in a one-generation reproductive study, the fungicidal compound triphenyltin hydroxide (fentin) was administered to adult japanese quail for 6 weeks at dietary levels of 3 and 30 ppm. reproduction was significantly impaired in the high-dose group. the principal adverse finding was a marked increase in embryonic mortality, resulting in a lower hatch rate. furthermore, a reduction in egg production was observed with ongoing duration of treatment. most of the other reproduction-related parameters w ... | 2006 | 16162336 |
| [a spinal cord injury caused by a migrating kirschner wire following osteosynthesis of the clavicle: a case review]. | a case of penetrating spinal cord injury in 47 year old man, caused by migration of kirschner wire is presented. the patient underwent the operation for acromioclavicular luxation 2 years ago--osteosynthesis with the use of 2 kirschner wires. admission with clinical symptoms of severe paraparesis of lower limbs. ct proved penetration of the first k-wire transversally through spinal cord in the level c7/t1, the second one stopped in the right transversal foramen t4. emergent operation--extraction ... | 2005 | 16164089 |
| correlation of magnetic resonance imaging and pathologic size of infiltrating lobular carcinoma of the breast. | determining the extent of infiltrating lobular carcinoma (ilca) in the breast is difficult. this study was designed to determine if the size of ilca on magnetic resonance imaging (mri) correlated with final pathology. | 2005 | 16164936 |
| effects of supplementation of beta-glucan on the growth performance and immunity in broilers. | two experiments were conducted to evaluate the efficacy of beta-glucan on commercial broilers. in experiment 1, one hundred and forty-four broiler chicks were employed in a 2x3 factorial design with cage and open floor housing with three levels of beta-glucan viz. 0%, 0.02% and 0.04%. in experiment 2, ninety-six broilers were used with 4 treatments: no beta-glucan and antibiotic (t1), beta-glucan 0.03% (t2), antibiotic (t3), and beta-glucan 0.03% + antibiotic (t4) for 34 d with 3 replicates of 8 ... | 2006 | 16165172 |
| the multidisciplinary rectal cancer treatment: main convergences, controversial aspects and investigational areas which support the need for an european consensus. | during the past decades staging and treatment of rectal cancer are used different in europe and in north america. to promote a process to integrate the daily practice with the best evidence of the literature an international conference was organized in italy. agreement between experts, centres, and specialists who participated in the conference are reported. | 2005 | 16165238 |
| medullary thyroid carcinoma arises in the absence of prolactin signaling. | prolactin, a pituitary hormone, exerts pleiotropic effects in various cells. these effects are mediated by a membrane receptor highly expressed in many tissues. to analyze prolactin effects on the thyroid gland, we first identified prolactin receptor (prlr) mrnas by in situ hybridization. to further evaluate the physiologic relevance of prlr actions in the thyroid in vivo, we used prlr knockout mice. whereas the histologic structure of thyroid of prlr-null mice was not disturbed, we show that t4 ... | 2005 | 16166330 |
| periplasmic domains define holin-antiholin interactions in t4 lysis inhibition. | bacteriophage t4 effects host lysis with a holin, t, and an endolysin, e. t and e accumulate in the membrane and cytoplasm, respectively, throughout the period of late gene expression. at an allele-specific time, t triggers to disrupt the membrane, allowing e to enter the periplasm and attack the peptidoglycan. t triggering can be blocked by secondary infections, leading to the state of lysis inhibition (lin). lin requires the t4 antiholin, ri, and is sensitive to the addition of energy poisons. ... | 2005 | 16166524 |
| the role of the sternum, costosternal articulations, intervertebral disc, and facets in thoracic sagittal plane biomechanics: a comparison of three different sequences of surgical release. | eighteen human torsos were used in three experiments (a, b, and c) to determine the changes in sagittal motion due to three different sequences of three surgical releases. | 2005 | 16166888 |
| changes in intraocular pressure and corneal and retinal nerve fiber layer thicknesses in hypothyroidism. | to evaluate the changes in intraocular pressure (iop), corneal thickness (ct), and retinal nerve fiber layer thickness (rnflt) in patients with hypothyroidism before and after treatment. | 2005 | 16167286 |
| prognostic value of tumor regression evaluated after first course of radiotherapy for anal canal cancer. | to evaluate whether the tumor response after an initial course of irradiation predicts for colostomy-free survival and overall survival in patients with anal canal cancer. | 2005 | 16169674 |
| thyroid hormones and fetal brain development. | thyroid hormones are intricately involved in the developing fetal brain. the fetal central nervous system is sensitive to the maternal thyroid status. critical amounts of maternal t3 and t4 must be transported across the placenta to the fetus to ensure the correct development of the brain throughout ontogeny. severe mental retardation of the child can occur due to compromised iodine intake or thyroid disease. this has been reported in areas of the world with iodine insufficiency, new guinea, and ... | 2005 | 16170282 |
| [comparison of the osteogenic activity of bone morphogenetic protein (bmp) mutants]. | modification of the heparin binding site by alteration of the amino acid sequence of bone morphogenetic protein-2 (bmp-2) results in a change in the local retention time. the purpose of this study was to compare the osteogenic activity of t3 and t4, two mutants with increased binding capacity to heparin, and b2gdf-5 a mutant resulting from the fusion of the n-terminal amino acid sequence of bmp-2 and the c-terminal sequence of gdf-5 with wild-type bmp-2 in vivo. | 2005 | 16170576 |
| efficacy and toxicity of fluorouracil, doxorubicin, and cisplatin/nedaplatin treatment as neoadjuvant chemotherapy for advanced esophageal carcinoma. | patients with advanced esophageal carcinoma including clinical t4 tumor, extensive lymph node metastasis, or intramural metastasis have a dismal prognosis, despite recent multimodality treatments. the aim of this study was to evaluate the efficacy and toxicity of neoadjuvant chemotherapy using fluorouracil, doxorubicin, and cisplatin or nedaplatin (fap/n) in these patients. | 2005 | 16170897 |
| assessing the quality of colorectal cancer staging: documenting the process in improving the staging of node-negative colorectal cancer. | examination of 14 or more nodes is the optimal criterion to accurately stage node-negative colorectal cancer and predict outcome. | 2005 | 16172297 |
| analysis of t-cell receptor gene rearrangement for predicting clinical outcome in patients with cutaneous t-cell lymphoma: a comparison of southern blot and polymerase chain reaction methods. | to extend previous observations regarding the prognostic value of analyzing lymph node dna from patients with cutaneous t-cell lymphoma for the presence of a monoclonal t-cell population by southern blot vs polymerase chain reaction (pcr) methods. | 2005 | 16172307 |
| thyroid hormone concentrations, disease, physical function, and mortality in elderly men. | physiological changes in thyroid hormone concentrations might be related to changes in the overall physical function in the elderly. | 2005 | 16174720 |
| cd10 expression in colorectal carcinoma correlates with liver metastasis. | if it were possible to identify the features of primary colorectal carcinoma that were associated with liver metastasis, these features could be used as predictors of liver metastasis. | 2005 | 16175325 |
| cold adaptation and thyroid hormone metabolism. | resting oxygen consumption and energy expenditure is sensitive to slight alterations in thyroid function. this means that timing and magnitude of cold adaptation would to some extent depend on thyroid function. local thyroid hormone metabolism is important for energy expenditure and dissipation of heat in special tissues. recruitment of brown adipocytes and upregulation of uncoupling protein 1 in mitochondria depends on high tissue t3 concentrations. most of this t3 is derived from local 5' deio ... | 2005 | 16175491 |
| effects of recombinant human thyrotropin on heart rate variability and blood pressure in patients on l-thyroxine-suppressive therapy for differentiated thyroid carcinoma. | recombinant human thyrotropin (rhtsh) is now currently used for the follow-up of patients with differentiated thyroid carcinoma (dtc) after total thyroid ablation. side effects after rhtsh could involve the autonomic system and tsh receptors are possibly expressed in the heart and coronary arteries. | 2005 | 16179790 |
| region-specific effects of hypothyroidism on the relative expression of thyroid hormone receptors in adult rat brain. | the aim of this study was to determine whether changes in the circulating thyroid hormone (th) and brain synaptosomal th content affected the relative levels of mrna encoding different thyroid hormone receptor (tr) isoforms in adult rat brain. northern analysis of polya+rna from cerebral cortex, hippocampus and cerebellum of control and hypothyroid adult rats was performed in order to determine the relative expression of all tr isoforms. circulating and synaptosomal th concentrations were determ ... | 2005 | 16180094 |
| clinical evaluation of low-dose cisplatin and 5-fluorouracil as adjuvant chemoradiotherapy for advanced squamous cell carcinoma of the esophagus. | the aim of this retrospective study was to evaluate the effectiveness of low-dose cisplatin and 5-fluorouracil (low-dose fp) as an adjuvant chemoradiotherapy for resected advanced squamous cell carcinoma of the esophagus. from 1994 to 1999, 57 patients who showed an invasion of the tumor over the muscularis propria (t2-t4), regional lymph node metastasis (n1), and no distant metastasis (m0) were enrolled in this analysis. postoperative chemoradiotherapy (crt group) was performed on 14 of the pat ... | 2005 | 16180698 |
| thyroid function and morphology in patients affected by williams syndrome. | to evaluate the prevalence of abnormalities of thyroid function and morphology in a cohort of patients with williams syndrome (ws). | 2005 | 16181239 |
| high-dose-rate endorectal brachytherapy in the treatment of locally advanced rectal carcinoma: technical aspects. | in this era of new radiation technologies and tumor imaging, a high-dose-rate endorectal brachytherapy has been developed and tested in a phase i/ii study of advanced rectal tumors. in this article, we report technical aspects of the treatment modality. | 2005 | 16182224 |
| comparison of three different epidural solutions in off-pump cardiac surgery: pilot study. | immediate extubation using thoracic epidural analgesia (tea) has become more popular after off-pump coronary artery bypass grafting (opcab). in this randomized prospective double-blind study, we present the first comparison of preoperative and postoperative haemodynamics during different regimens of tea for immediate extubation after cardiac surgery. | 2005 | 16183682 |
| [thyroid disorders in diabetic patients]. | to evaluate thyroid function and morphology in all diabetic outpatients from our institution. | 2005 | 16184251 |
| [dopaminergic and somatostatinergic pathways decrease serum thyrotropin in rats bearing the 256-walker mammary carcinoma]. | the hypothalamus-pituitary-thyroid axis was studied in rats with the "low t(3) syndrome" caused by the implantation of the walker-256 mammary carcinoma. male adult rats were injected s.c. with 1 x 106 viable tumoral cells and killed 10 days later. the tumor development was associated with decreased thyroid activity characterized by a approximately 15% reduction in the nuclear area of the thyrocytes and 131i-thyroid uptake (down by approximately 50%), as well as about 70% lower serum levels of t4 ... | 2005 | 16184254 |
| hyperthyroidism due to secretion of human chorionic gonadotropin in a patient with metastatic choriocarcinoma. | a 26-year-old pregnant woman presenting with repeated episodes of vaginal bleeding, weight loss, and shortness of breath was diagnosed with choriocarcinoma with metastases to both lungs. chorionic gonadotropin levels (hcg) were >2.5 x 10(6)mu/ml. consistent with hcg-induced subclinical hyperthyroidism, she had a suppressed tsh of 0.037 mu/l (0.49 - 4.67), a t4 of 18.1 microg/dl (4.9 - 10.7), and t3 of 136 ng/dl (45 - 137). chemotherapy with a combined regimen with etoposide, methotrexate, and da ... | 2005 | 16184264 |
| increasing the length of the single-stranded overhang enhances unwinding of duplex dna by bacteriophage t4 dda helicase. | dda has been shown previously to be active as a monomer for dna unwinding [nanduri et al. (2002) proc. natl. acad. sci. u.s.a. 99, 14722] and streptavidin displacement [byrd and raney (2004) nat. struct. mol. biol. 11, 531]. however, its activity for streptavidin displacement increased as a function of the length of single-stranded dna. we investigated whether dda exhibited enhanced dna unwinding of partially duplex dna substrates as a function of increasing the length of the single-stranded ove ... | 2005 | 16185067 |
| the use of nonnatural nucleotides to probe the contributions of shape complementarity and pi-electron surface area during dna polymerization. | it is widely accepted that the dynamic behavior of dna polymerases during translesion dna synthesis is dependent upon the nature of the dna lesion and the incoming dntp destined to be the complementary partner. we previously demonstrated that 5-nitro-1-indolyl-2'-deoxyribose-5'-triphosphate, a nonnatural nucleobase possessing enhanced base-stacking abilities, can be selectively incorporated opposite an abasic site (reineks, e. z., and berdis, a. j. (2004) biochemistry 43, 393-404.). while the en ... | 2005 | 16185078 |
| a potential chemotherapeutic strategy for the selective inhibition of promutagenic dna synthesis by nonnatural nucleotides. | this manuscript reports the development of nonnatural nucleotide analogues that are preferentially incorporated opposite an abasic site, a common form of dna damage. competition experiments confirm that all of the nonnatural nucleotides tested are poorly incorporated into unmodified dna. however, two analogues that contain extensive pi-electron density (5-nitro-indolyl-2'deoxyriboside triphosphate (5-nitp) and 5-phenyl-indolyl-2'deoxyriboside triphosphate (5-phitp)) are selectively inserted oppo ... | 2005 | 16185079 |
| an artificial activator that contacts a normally occluded surface of the rna polymerase holoenzyme. | many activators of transcription are sequence-specific dna-binding proteins that stimulate transcription initiation through interaction with rna polymerase (rnap). such activators can be constructed artificially by fusing a dna-binding protein to a protein domain that can interact with an accessible surface of rnap. in these cases, the artificial activator is directed to a target promoter bearing a recognition site for the dna-binding protein. here we describe an artificial activator that functi ... | 2005 | 16185714 |
| [effects of endoscopic sympathicotomy in carotid and vertebral arteries in the surgical treatment of primary hyperhidrosis]. | analyze, in patients with primary hyperhidrosis (ph) who was undergone to videothoracoscopic sympathicotomy, the degree of vascular denervation after surgical transection of the thoracic sympathetic chain by measuring ultrasonografic parameters in carotid and vertebral arteries. | 2005 | 16186983 |
| naturally occurring mutations in the thyroglobulin gene. | thyroglobulin (tg) is a large glycoprotein dimer secreted into the follicular lumen. it serves as the matrix for the synthesis of thyroxine (t4) and triiodothyronine (t3), and the storage of thyroid hormone and iodide. in response to demand for thyroid hormone secretion, tg is internalized into the follicular cell and digested in lysosomes. subsequently, the thyronines t4 (approximately 80%) and t3 (approximately 20%) are released into the blood stream. biallelic mutations in the tg gene have be ... | 2005 | 16187910 |
| intrathecal clonidine reduces the incidence of ischemia-provoked ventricular arrhythmias in a canine postinfarction heart failure model. | intrathecal clonidine (itc) is used clinically to manage neuropathic pain but frequently causes hypotension and bradycardia due to centrally mediated sympatholytic effects. | 2005 | 16188594 |
| patient characteristics rather than the type of dialyser predict the variability of endothelial derived surface molecules in chronic haemodialysis patients. | cardiovascular disease (cvd) is a frequent complication in chronic haemodialysis (hd) patients. endothelial dysfunction, as measured by soluble cellular adhesion molecules (scam) and von willebrand factor (vwf) in plasma, is an early manifestation of cvd. today, it is unknown if, and to what extent, their levels are influenced by the type of dialyser. | 2005 | 16188898 |