| thyroid function differently affects serum cystatin c and creatinine concentrations. | cystatin c (cys c) is a cysteine protease inhibitor produced at a constant rate by nucleated cells, filtered through the glomerular membrane and reabsorbed by kidney tubular cells. aim of this cross-sectional and longitudinal study was to assess serum cys c and creatinine (crea) concentrations in thyroid dysfunction. one hundred and eighty-one patients, 26 with untreated non-toxic nodular goiter, 58 with hyperthyroidism, 31 on l-t4 suppressive therapy for non-toxic nodular goiter, 35 with short- ... | 2005 | 15966508 |
| resistance to thyroid hormone associated with autoimmune thyroid disease in a turkish family. | the syndrome of resistance to thyroid hormone (rth) is characterized by impaired tissue responses to thyroid hormone. hashimoto's thyroiditis is the most common thyroid autoimmune disease. we present a turkish family with both rth and hashimoto's thyroiditis. rth was detected through the presence of point mutation in thyroid hormone receptor (tr), and hashimoto's thyroiditis was diagnosed due to the presence of thyroid autoantibodies. the proposita, her affected mother as well as her unaffected ... | 2005 | 15966514 |
| non-genomic effect of steroids on oxytocin-stimulated intracellular mobilization of calcium and on prostaglandin f2alpha and e2 secretion from bovine endometrial cells. | progesterone (p4) was found to interfere directly with the interaction of oxytocin (ot) with its own receptor in bovine endometrium. the aim of these studies was to investigate whether other steroids have a similar effect. endometrial slices and epithelial endometrial cells from days 14 to 18 of the estrous cycle were used. progesterone (p4), pregnenolone (p5), 17beta-hydroxyprogesterone (17-ohp4), the p4 receptor antagonist (ap4), and testosterone (t4) did not affect (p > 0.01) basal secretion ... | 2005 | 15967166 |
| pancreaticoduodenectomy is curative in the majority of patients with node-negative ampullary cancer. | survival following resection for ampullary carcinoma may be influenced by 1 or more clinical or pathologic variables. | 2005 | 15967899 |
| relationship between factor xiii activity, fibrinogen, haemostasis screening tests and postoperative bleeding in cardiopulmonary bypass surgery. | we investigated the relationship between factor xiii, fibrinogen, blood coagulation screening tests and postoperative bleeding in 98 patients undergoing cardiopulmonary bypass (cpb) surgery. all patients received aprotinin. blood samples were collected preoperatively (t1),after termination of cpb (t2),12 h (t3) and 24 h (t4) after surgery to determine fxiii activity, fibrinogen, platelet count, prothrombin time (pt), activated partial thromboplastin time (aptt) and d-dimers (dd). laboratory resu ... | 2005 | 15968395 |
| assessment of density functionals for the high-spin/low-spin energy difference in the low-spin iron(ii) tris(2,2'-bipyridine) complex. | in the iron(ii) low-spin complex [fe(bpy)3]2+, the zero-point energy difference between the 5t2g(t4(2g)e2g) high-spin and the 1a(1g)(t(6)2g) low-spin states, delta(e)0hl, is estimated to lie in the range of 2500-5000 cm(-1). this estimate is based on the low-temperature dynamics of the high-spin-->low-spin relaxation following the light-induced population of the high-spin state and on the assumption that the bond-length difference between the two states delta(r)hl is equal to the average value o ... | 2005 | 15968698 |
| attentional training in elderly subjects affects voluntarily oriented, but not automatic attention: a neurophysiological study. | our study aimed at investigating the effect of repetitive recordings on somatosensory evoked potentials (seps) related to spatial attention in a population of healthy elderly subjects. | 2005 | 15970344 |
| dopaminergic influence on thyrotropin secretion in primary hypothyroidism. | this study was conducted to assess the influence of dopamine on thyrotropin secretion in patients with primary hypothyroidism before and after optimized l-thyroxin replacement therapy. thyrotropin responses to dopamine infusion (4 microg/kg/min over 3 hours) and iv metoclopramide (10 mg bolus), a dopamine receptor blocker were studied in 25 consecutive patients with primary hypothyroidism before and after achieving stable euthyroid state and compared with 15 normal age-matched controls. thyrotro ... | 2005 | 15971151 |
| local staging of rectal carcinoma and assessment of the circumferential resection margin with high-resolution mri using an integrated parallel acquisition technique. | to assess the diagnostic accuracy of integrated parallel acquisition technique (ipat) in local staging of rectal carcinoma in comparison to conventional high-resolution mri. | 2005 | 15971183 |
| thyroid hormone and prolactin profiles in male and female turkeys following photostimulation. | the turkey hen, a photosensitive bird, will become photorefractory (pr) during the reproductive cycle and will cease laying despite a stimulatory day length. this response is thought to be "programmed" by hormonal events early in the reproductive cycle. the turkey tom, in contrast, produces semen for extended periods and has not been shown to exhibit pr. we compared hormone profiles following photostimulation of hens and toms to assess differences that might program one, but not the other, for p ... | 2005 | 15971534 |
| pyrethroids used indoor-ambient monitoring of pyrethroids following a pest control operation. | house dust and airborne particles (pm) were sampled before (t1) and 1 day (t2), 4-6 months (t3) as well as 10-12 months (t4) after a pest control operation (pco). cyfluthrin was applied in 11, cypermethrin in 1, deltamethrin in three and permethrin in four interiors. the pyrethroid concentrations in house dust and pm were measured by gc/ms with a detection limit for all pyrethroids of 0.5 mg/kg house dust and of 1 ng/m3 pm for deltamethrin and permethrin and 3 ng/m3 pm for cyfluthrin and cyperme ... | 2005 | 15971858 |
| improving the biosafety of cell sorting by adaptation of a cell sorting system to a biosafety cabinet. | the jet-in-air cell sorters currently available are not very suitable for sorting potentially biohazardous material under optimal conditions because they do not protect operators and samples as recommended in the guidelines for safe biotechnology. to solve this problem we have adapted a cell sorting system to a special biosafety cabinet that satisfies the requirements for class ii cabinets. with aid of this unit, sorting can be performed in conformance with the recommendations for biosafety leve ... | 2005 | 15973698 |
| bone status in an animal model of chronic sub-optimal nutrition: a morphometric, densitometric and mechanical study. | in children, inappropriate eating habits can induce a disease known as nutritional dwarfing (nd). due to the link between nutritional condition and bone growth, the effects induced by a 20 % reduction of food intake on bone competence were assessed in an animal model of nd. bone status during catch-up growth was also analysed. male wistar rats were divided into control (c) and nd groups. c rats were fed ad libitum. nd received 80 % of the diet consumed by c for 4 weeks (t4); thereafter, they wer ... | 2005 | 15975165 |
| in with the new, out with the old? comparison of two approaches for psoas compartment block. | we compared the approaches of winnie and capdevila for psoas compartment block (pcb) performed by a single operator in terms of contralateral spread, lumbar plexus blockade, and postoperative analgesic efficacy. sixty patients underwent pcb (0.4 ml/kg levobupivacaine 0.5%) and subsequent spinal anesthesia for primary joint arthroplasty (hip or knee) in a prospective, double-blind study. patients were randomly allocated to undergo pcb by using the capdevila (group c; n = 30) or a modified winnie ... | 2005 | 15976242 |
| [the application of extended resection for non-small cell lung cancer]. | lung cancers invading the neighboring anatomic structures such as the chest wall, diaphragm, great vessels, and tracheal carina are categorized as t3 or t4 and regarded as locally advanced lung cancer. these patient populations should be treated with an aggressive, multidisciplinary approach with surgery, chemotherapy, and radiotherapy in a manner that maximizes the chance for long-term cure while minimizing the overall risks of treatment. the surgical indications, mode of resection, and combine ... | 2005 | 15977578 |
| [perioperative management of extended surgery for advanced lung cancer]. | extended surgery for advanced non-small cell lung cancer includes combined resection of t3 or t4 organs and extended lymph node dissection in n2 or n3 cases. it is well known that the incidence of complications with extended surgery is higher in comparison with standard surgery due to the greater extent of invasiveness of the former. the management of extended surgery patients requires an understanding of the characteristic complications and their frequency for each type of surgery. perioperativ ... | 2005 | 15977579 |
| identification of human fetal liver mirnas by a novel method. | micrornas (mirnas) are short 20-25 nucleotides rna molecules that have been shown to regulate gene expressions in a variety of eukaryotic systems. mirnas are widespread in eukaryotes and several hundred of mirnas have been identified, but still a lot of mirnas have not been detected in various eukaryotic organisms. however, it is not an easy work to clone mirnas by traditional methods. here, we describe the identification of 27 mirnas from a human fetal liver cdna library by a novel cloning meth ... | 2005 | 15978578 |
| human volunteers receiving escherichia coli phage t4 orally: a safety test of phage therapy. | fifteen healthy adult volunteers received in their drinking water a lower escherichia coli phage t4 dose (10(3) pfu/ml), a higher phage dose (10(5) pfu/ml), and placebo. fecal coliphage was detected in a dose-dependent way in volunteers orally exposed to phage. all volunteers receiving the higher phage dose showed fecal phage 1 day after exposure; this prevalence was only 50% in subjects receiving the lower phage dose. no fecal phage was detectable a week after a 2-day course of oral phage appli ... | 2005 | 15980363 |
| non-invasive management of fetal goiter during maternal treatment of hyperthyroidism in grave's disease. | there is an increased risk of fetal goiter in patients who have a history of grave's disease and undergo propylthiouracil (ptu) treatment during pregnancy. in this report, we describe a case of a fetal goiter detected by antenatal ultrasound at the 26th week of gestation in a mother treated with ptu for grave's disease. a 32 x 38 x 20 mm fetal goiter was detected, each lobe measured 30 x 18 x 18 mm and estimated volume was 10 cm3. subsequently, fetal thyroid function was assessed by umbilical fe ... | 2005 | 15980635 |
| primary malignant rhabdoid tumor of the central nervous system--a comprehensive review. | this paper presents the case of an eight-year-old girl who presented with headache and vomiting and was found to harbor a right fronto-temporo-parietal, partially cystic and centrally solid tumor that measured 11 x 8 x 7 cm. this vascular tumor was gross totally removed. the initial histopathologic diagnosis was hemangiopericytoma and the patient received a total dose of 5330 cgy of external cranial radiation. twelve months later, the patient presented with left lower quadrant pain and limping a ... | 2005 | 15980975 |
| extrapedicular approach of percutaneous vertebroplasty in the treatment of upper and mid-thoracic vertebral compression fracture. | to evaluate the clinical outcome of the extrapedicular approach of percutaneous vertebroplasty (pvp) for upper and mid-thoracic vertebral compression fractures in patients. | 2005 | 15981725 |
| correlation of her-2/neu gene amplification with other prognostic and predictive factors in female breast carcinoma. | the purpose of this study was to determine if any relationship exists between her-2/neu gene amplification and estrogen receptor (er), progesterone receptor (pr), mib-1, grade, size and age in female breast cancer. five hundred and eighteen female patients with invasive breast carcinoma, 390 ductal and 128 lobular, in which assessment of her-2/neu amplification by fluorescence in-situ hybridization (fish) has been performed, were reviewed retrospectively. each patient was further assessed for er ... | 2005 | 15982396 |
| stable myocardial function and endocrine dysfunction during experimental brain death. | the origin of cardiac impairment during brain death (bd) is controversial. using a pig experimental model we sought to assess hormonal changes during the first stage of brain death and how these changes contribute to hemodynamic alteration and myocardial dysfunction. | 2005 | 15982623 |
| hyperactivity, impaired learning on a vigilance task, and a differential response to methylphenidate in the trbetapv knock-in mouse. | the thyroid hormones (t3 and t4) play a critical role in brain development, and thyroid abnormalities have been linked to a variety of psychiatric and neuropsychological disorders. among patients with the rare genetic syndrome resistance to thyroid hormone (rth), 40-70% meet the diagnostic criteria for attention deficit-hyperactivity disorder (adhd). rth is caused by a mutation in the thyroid receptor beta (thrb) gene that results in reduced binding of t3 to its receptor and elevated concentrati ... | 2005 | 15983791 |
| hypothyroidism increases fos immunoreactivity in cholinergic neurons of brain medullary dorsal vagal complex in rats. | hypo- or hyperthyroidism is associated with autonomic disorders. we studied fos expression in the medullary dorsal motor nucleus of the vagus (dmv), nucleus tractus solitarii (nts), and area postrema (ap) in four groups of rats with different thyroid states induced by a combination of drinking water and daily intraperitoneal injection for 1-4 wk: 1) tap water and vehicle; 2) 0.1% propylthiouracil (ptu) and vehicle; 3) ptu and thyroxine (t4; 2 microg/100 g); and 4) tap water and t4 (10 microg/100 ... | 2005 | 15985455 |
| interactions among thyroid function, insulin sensitivity, and serum lipid concentrations: the fremantle diabetes study. | recent observations in healthy subjects showed that insulin resistance modifies the relationship between serum cholesterol and thyroid function. | 2005 | 15985488 |
| functional analysis of the cytochrome p450 monooxygenase gene bcbot1 of botrytis cinerea indicates that botrydial is a strain-specific virulence factor. | the micrographic phytopathogen botrytis cinerea causes gray mold diseases in a large number of dicotyledonous crop plants and ornamentals. colonization of host tissue is accompanied by rapid killing of plant cells ahead of the growing hyphen, probably caused by secretion of nonspecific phytotoxins, e.g., the sesquiterpene botrydial. although all pathogenic strains tested so far had been shown to secrete botrydial and although the toxin causes comparable necrotic lesions as infection by the fungu ... | 2005 | 15986930 |
| an end-healing enzyme from clostridium thermocellum with 5' kinase, 2',3' phosphatase, and adenylyltransferase activities. | we identify and characterize an end-healing enzyme, cthpnkp, from clostridium thermocellum that catalyzes the phosphorylation of 5'-oh termini of dna or rna polynucleotides and the dephosphorylation of 2',3' cyclic phosphate, 2'-phosphate, and 3'-phosphate ribonucleotides. cthpnkp also catalyzes an autoadenylylation reaction via a polynucleotide ligase-type mechanism. these characteristics are consistent with a role in end-healing during rna or dna repair. cthpnkp is a homodimer of an 870-amino- ... | 2005 | 15987807 |
| thyroid disease in pregnancy and childhood. | the subject of thyroid disease in pregnancy is receiving increasing attention from many scientific disciplines. thyroid function in pregnancy is characterised by a t4 surge at 12 weeks declining thereafter. serum thyroid hormone concentrations fall in the second half of pregnancy but there are few data on normal reference ranges. fetal brain development depends on t4 transport into the fetus which in turn depends on sufficient maternal iodine supply. there is current concern that adequate iodisa ... | 2005 | 15988403 |
| [endoscopic operations in invasive cancer of the urinary bladder]. | long-term results of conservative treatment of 153 patients with invasive cancer of the urinary bladder were studied retrospectively. the patients had stage t2 (n=121, 79.1%), t3 (n=26, 17%), t4 (n=6, 3.9%). all the patients had transitional cell cancer. gi, g2 and g3 tumors were registered in 104 (68%), 35 (24%) and 12 (8%) cases, respectively. 88 (57.5%) patients received combined treatment, 65 (42.5%) patients--only surgery. in the patients with a small invasive tumor of the urinary bladder s ... | 2005 | 15989025 |
| salvage surgery after failure of very accelerated radiotherapy in advanced head-and-neck squamous cell carcinoma. | to assess the efficacy and toxicity of salvage surgery for local or cervical nodal recurrence after accelerated radiotherapy for locally advanced head-and-neck squamous cell carcinoma (hnscc). | 2005 | 15990011 |
| tumor site predicts outcome after radiochemotherapy in squamous-cell carcinoma of the anal region: long-term results of 101 patients. | this study was designed to assess the long-term results following radiochemotherapy in patients with anal squamous-cell carcinoma and to evaluate the impact of tumor location on response, survival, and colostomy-free survival. | 2005 | 15991058 |
| circulating ghrelin in thyroid dysfunction is related to insulin resistance and not to hunger, food intake or anthropometric changes. | ghrelin is a gastric peptide that plays a role in appetite stimulation, energy balance and possibly in insulin resistance. hyperthyroidism is a situation where negative energy balance and insulin resistance coexist, while in hypothyroidism a positive energy balance and normal insulin sensitivity predominate. we investigated ghrelin levels and their relationship with hunger, food intake and both anthropometric and insulin resistance parameters in patients with thyroid dysfunction. | 2005 | 15994748 |
| accessibility of nitroxide side chains: absolute heisenberg exchange rates from power saturation epr. | in site-directed spin labeling, the relative solvent accessibility of spin-labeled side chains is taken to be proportional to the heisenberg exchange rate (w(ex)) of the nitroxide with a paramagnetic reagent in solution. in turn, relative values of w(ex) are determined by continuous wave power saturation methods and expressed as a proportional and dimensionless parameter pi. in the experiments presented here, niedda is characterized as a paramagnetic reagent for solvent accessibility studies, an ... | 2005 | 15994891 |
| accessibility and dynamics of nitroxide side chains in t4 lysozyme measured by saturation recovery epr. | long pulse saturation recovery electron paramagnetic resonance spectroscopy is applied to the investigation of spin-labeled side chains placed along a regular helix extending from 128 to 135 in t4 lysozyme. under an argon atmosphere, analysis of the exponential saturation recovery curves gives the spin-lattice relaxation rates of the nitroxides, which depend on the nitroxide side-chain dynamics. in the presence of the fast-relaxing paramagnetic reagents o(2) or niedda, global analysis of the sat ... | 2005 | 15994892 |
| theory of electrostatically regulated binding of t4 gene 32 protein to single- and double-stranded dna. | bacteriophage t4 gene 32 protein (gp32) is a single-stranded dna binding protein, which is essential for dna replication, recombination, and repair. in a recent article, we described a new method using single dna molecule stretching measurements to determine the noncooperative association constants k(ds) to double-stranded dna for gp32 and *i, a truncated form of gp32. in addition, we developed a single molecule method for measuring k(ss), the association constant of these proteins to single-str ... | 2005 | 15994897 |
| predictors of thyroid gland invasion in glottic squamous cell carcinoma. | this study examines preoperative clinical and intraoperative histopathologic characteristics that can be used to predict thyroid gland invasion in the setting of squamous cell carcinoma (scc) of the glottis. | 2005 | 15995515 |
| expression of cardiovascular and behavioural components of conditioned fear to context in t4 spinally transected rats. | a spinal cord transection at the fourth thoracic level (t4) results in paraplegia. it also removes supraspinal control of sympathetic outflow to most viscera and their blood vessels but spares the heart. we studied the effects of such a transection on the expression of the conditioned fear response to context, which includes freezing, 22 khz ultrasonic vocalisations, a marked pressor response and a slowly rising tachycardia. rats implanted with radiotelemetric probes were fear conditioned, teste ... | 2005 | 15996622 |
| regulation of erythrocyte na-k-2cl cotransport by threonine phosphorylation. | a method is described to measure threonine phosphorylation of the na-k-2cl cotransporter in ferret erythrocytes using readily available antibodies. we show that most, if not all, cotransporter in these cells is nkcc1, and this was immunoprecipitated with t4. cotransport rate, measured as 86rb influx, correlates well with threonine phosphorylation of t4-immunoprecipitated protein. the cotransporter effects large fluxes and is significantly phosphorylated in cells under control conditions. transpo ... | 2005 | 15996636 |
| endocrine disruptive effects of polychlorinated biphenyls on the thyroid gland in female rats. | polychlorinated biphenyls (pcbs) are persistent environmental pollutants. aroclor 1221 (a1221) and aroclor 1254 (a1254) are commercial pcb mixtures with low and high number of chlorination, respectively. we have comparatively investigated effects of a1221 and a1254 on serum levels of thyroid hormones and thyroid gland histology in adult female wistar rats. animals were subcutaneously injected with a1221 (10 mg/kg) or a1254 (10 mg/kg) for six weeks. one group of animals served as control. at the ... | 2005 | 15997204 |
| [plasma concentration of endothelin-1 after myocutaneous latissimus dorsi-transplantation -- role in reperfusion injury]. | the success of a free flap transplantation is based on a sufficient microanastomosis which meets the following requirements: a pedicle placed without kinking or twisting, a good drainage, a well defined recipient vessel and integrity of the endothelium. the aim of this study was to determine whether operation-related ischaemia through flap transplantation and tourniquet induces an increase of endothelin-1 plasma levels as one cause of vasospasm during microvascular procedures. we focused our att ... | 2005 | 15997431 |
| trends in inflammatory breast carcinoma incidence and survival: the surveillance, epidemiology, and end results program at the national cancer institute. | inflammatory breast carcinoma (ibc) appears to be a clinicopathologic entity distinct from noninflammatory locally advanced breast cancer (labc). we examined incidence and survival trends for ibc in surveillance, epidemiology, and end results (seer) program data with a case definition designed to capture many of its unique clinical and pathologic characteristics. | 2005 | 15998949 |
| [prostate cancer at high risk of recurrence: results of 12 months of radiotherapy-hormone therapy]. | to evaluate the risk of progression after conformal radiotherapy combined with 12 months of adjuvant hormone therapy in a series of patients with prostate cancer considered to be at high risk of progression. | 2005 | 15999604 |
| factors influencing tumour relapse after total laryngectomy. | to determine the prognostic factors predictive of tumour recurrence after surgical treatment for laryngeal carcinoma with total laryngectomy. | 2005 | 15999669 |
| are dexamethasone suppression test nonsuppression and thyroid dysfunction related to a family history of dementia in patients with major depression? an exploratory study. | recent data suggest that the low thyroid function syndrome in depression is nonspecific. they also suggest that depression may constitute a risk factor for the development of dementia, especially in atypical patients who have high rates of hypothalamo-pituitary-adrenal axis disorders. this study aimed to search for correlations among dexamethasone suppression test (dst) cortisol levels, thyroid indices, and family history of dementia in patients with depression. | 2005 | 15999950 |
| surgical management of t3 and t4 lung cancer. | locally advanced lung cancer (t(3) or t(4)) has a significantly worse prognosis than lower stage disease. however, this diagnosis is usually made radiologically, and experienced thoracic surgeons are familiar with the low radiologic to pathologic correlation in tumors that abut the great vessels, mediastinum, or chest wall. commonly these tumors do not directly invade adjacent structures and are, in fact, t(1) or t(2) tumors that are resectable through standard techniques. where there is no clea ... | 2005 | 16000611 |
| tnm classification for perihilar cholangiocarcinoma: comparison between 5th and 6th editions of the ajcc/uicc staging system. | a few investigators have evaluated the tnm classification for perihilar cholangiocarcinoma. the new sixth edition of the american joint committee on cancer (ajcc)/internal union against cancer (uicc) staging system focuses on vascular invasion and regional lymph node metastasis. | 2005 | 16001285 |
| significance of silver-stained nucleolar organizer regions in early diagnosis and prognosis of oral squamous cell carcinoma: a multivariate analysis. | argyrophilic nucleolar organizer regions (agnors) appear to be of diagnostic and prognostic significance in different types of human tumour. the present study examined the agnor counts in normal, premalignant and malignant oral mucosa to evaluate their potential as a biological marker for tumour progression and a prognostic predictor for treatment outcome in oral carcinomas. the spearmann's rank correlation analysis between agnor counts and various stages of tumour progression in oral mucosa exh ... | 2005 | 16001464 |
| [intraarterial concomitant chemoradiation for tongue cancer: analysis of 20 patients]. | subjects were 20 patients with tongue cancer treated between april 1996 and december 2002 with intraarterial infusion of cisplatin (60-120 mg/m2) (and docetaxel 10-30 mg/m2) and intravenous infusion of sodium thiosulfate followed by 5-fluorouracil (5-fu) (800-1000 mg/m2) for 3 to 5 days. all patients underwent radiation (50-80 gy). ten had stage ii, 4 stage iii, and 6 stage iv a disease. complete response at the primary site was achieved in 50% for t2, 67% for t3, and 0% for t4 lesions in those ... | 2005 | 16001727 |
| translocation of nicked but not gapped dna by the packaging motor of bacteriophage phi29. | the biomolecular mechanism that the double-stranded dna viruses employ to insert and package their genomic dna into a preformed procapsid is still elusive. to better characterize this process, we investigated packaging of bacteriophage phi29 dna with structural alterations. phi29 dna was modified in vitro by nicking at random sites with dnase i, or at specific sites with nicking enzyme n.bbvc ia. single-strand gaps were created by expanding site-specific nicks with t4 dna polymerase. packaging o ... | 2005 | 16002084 |
| progress towards development of an amphibian-based thyroid screening assay using xenopus laevis. organismal and thyroidal responses to the model compounds 6-propylthiouracil, methimazole, and thyroxine. | in response to the initial endocrine disruptor screening and testing advisory committee (edstac) recommendations, research was conducted on the development of a xenopus laevis based tail resorption assay for evaluating thyroid axis disruption. this research highlighted key limitations associated with relying on tail resorption as a measure of anti/thyroid activity. the most critical limitation being that tail tissues of tadpoles at metamorphic climax are insensitive to perturbation by thyroid ax ... | 2005 | 16002479 |
| oropharyngeal carcinoma and its treatment in finland between 1995-1999: a nationwide study. | the survival figures for advanced stage oropharyngeal carcinoma (opc) have remained moderate in spite of radical combined modality treatments. the purpose of this study was to investigate the used treatment approach and the outcome of opc in a nationwide study. retrospective clinicopathological data of all patients diagnosed with opc between 1995 and 1999 at the five university hospitals in finland were reviewed. all patients had a minimum 4-year follow-up. a total of 168 patients (145 men and 2 ... | 2006 | 16003551 |
| the use of the occupational disruptiveness scale of the neuropsychiatric inventory-nursing home version to measure the impact of rivastigmine on the disruptive behavior of nursing home residents with alzheimer's disease. | the neuropsychiatric inventory-nursing home version (npi-nh) was used to study the impact of rivastigmine (exelon; novartis pharmaceuticals corporation, east hanover, nj), on occupational disruptiveness (od), a proxy measure for professional caregiver burden. | 2005 | 16005409 |
| influence of thyroid hormone treatment on the respiratory activity of cerebral mitochondria from hypothyroid rats. a critical re-assessment. | effects of treatment with thyroid hormones l-3,5,3'-tri-iodothyronine (t3) and l-thyroxine (t4) on oxidative energy metabolism in cerebral mitochondria from hypothyroid adult rats were examined. it was observed that t3 and t4 stimulated respiratory activity in a substrate-specific and dose-dependent manner. the results also suggest that the synthesis of cytochrome aa3 and of cytochrome c may be dependent on both t3 as well as t4 whereas higher concentrations than normal of t3 and t4 may have a c ... | 2005 | 16005873 |
| effects of prophylactic thyroid hormone replacement in euthyroid hashimoto's thyroiditis. | hashimoto's thyroiditis is the most frequent autoimmune thyroid disease. l-thyroxine therapy can reduce the incidence and alleviate the symptoms of this disease. the aim of this study was to evaluate the effects of prophylactic l-thyroxine treatment on clinical and laboratory findings of patients who were euthyroid at the time of diagnosis. thirty-three patients who had diagnosis of euthyroid hashimoto's thyroiditis were randomized to two groups, one group received prophylactic l-thyroxine treat ... | 2005 | 16006728 |
| interleukin-6 polymorphism is associated with more aggressive prostate cancer. | : interleukin-6 (il-6) has an important role during prostate cancer progression and il-6 levels in the serum of patients with hormone refractory and metastatic prostate cancer are significantly increased compared with those in patients with hormone sensitive and localized prostate cancer. the g>c polymorphism at position -174 in the promoter of the il-6 gene has been associated with differences in il-6 transcription in vitro and il-6 protein levels in vivo. we determined the association of il-6 ... | 2005 | 16006970 |
| gingival bleeding on repeat probing after different time intervals in plaque-induced gingivitis. | the aim of this study was to assess agreement and association of gingival bleeding after repeated probing at different time intervals in subjects with gingivitis. twenty adults participated. periodontal probing (p approximately 1.27 mpa) was conducted at six sites of every tooth present. probing was repeated in different quadrants immediately after the first probing (t0), after 1 h (t1), 4 h (t4), and 24 h (t24). a total of 3,459 sites were probed twice. the mean proportion of sites bleeding on ... | 2005 | 16007473 |
| effects of oral administration of levothyroxine sodium on serum concentrations of thyroid gland hormones and responses to injections of thyrotropin-releasing hormone in healthy adult mares. | to determine the effects of levothyroxine sodium (l-t4) on serum concentrations of thyroid gland hormones and responses to injections of thyrotropin-releasing hormone (trh) in euthyroid horses. | 2005 | 16008227 |
| effects of oral administration of levothyroxine sodium on concentrations of plasma lipids, concentration and composition of very-low-density lipoproteins, and glucose dynamics in healthy adult mares. | to evaluate glucose and lipid metabolism in healthy adult horses administered levothyroxine sodium (l-t4). | 2005 | 16008228 |
| neuromuscular blocking properties of atracurium during sevoflurane or propofol anaesthesia in dogs. | to quantify the neuromuscular blockade (nmb) produced by atracurium in either sevoflurane or propofol-anaesthetized dogs. | 2005 | 16008719 |
| [significance of serum vascular endothelial growth factor test before radiotherapy in patients with nasopharyngeal carcinoma]. | to study the changes of serum vascular endothelial growth factor (vegf) and beta 2-microglobulin levels before and after radiotherapy in 58 patients with nasopharyngeal carcinoma (npc), and to elucidate the clinical significance of vegf and beta 2-microglobulin test before radiotherapy. | 2005 | 16009104 |
| the incidence of primary thyroid lymphoma in thyroid malignancies. | we investigated the incidence of primary thyroid lymphoma in thyroid malignancies. | 2004 | 16010091 |
| upper thoracic disc herniation followed by acutely progressing paraplegia. | case report. | 2005 | 16010280 |
| [histological criteria and metastasis of squamous cell carcinoma of the pinna]. | according to the guidelines for cancer of the skin in the head and neck region of the german association of otolaryngology, head and neck surgery squamous cell carcinoma (scc) of the pinna are classified by using the current tnm system of skin cancer. as soon as cartilage is infiltrated, irrespective of other criteria like tumour size, scc of the thin skin of the pinna are classified as t4 category. as therapy considerably depends on the tnm stage a review of the prognostic value of cartilage in ... | 2005 | 16010628 |
| the pd-(d/e)xk superfamily revisited: identification of new members among proteins involved in dna metabolism and functional predictions for domains of (hitherto) unknown function. | the pd-(d/e)xk nuclease superfamily, initially identified in type ii restriction endonucleases and later in many enzymes involved in dna recombination and repair, is one of the most challenging targets for protein sequence analysis and structure prediction. typically, the sequence similarity between these proteins is so low, that most of the relationships between known members of the pd-(d/e)xk superfamily were identified only after the corresponding structures were determined experimentally. th ... | 2005 | 16011798 |
| rapid antidepressant response after nocturnal trh administration in patients with bipolar type i and bipolar type ii major depression. | thyrotropin-releasing hormone (trh) is a tripeptide that produces endocrine and behavioral effects in animals and humans. some studies have shown transient antidepressant activity after morning administration of trh. we hypothesized that nocturnal administration of trh, when the circadian sensitivity of the trh receptor is at its peak, may result in a more robust antidepressant effect. | 2005 | 16012274 |
| procalcitonin as a marker of micro-inflammation in hemodialysis. | in searching for a rapid and sensitive test to detect micro-inflammation in patients on hemodialysis (hd), we measured serum procalcitonin (pct) levels and made a comparison with other traditional markers such as c-reactive protein (crp), serum amyloid (saa) and homocysteine, considered related to vascular damage. we investigated 51 hd patients, without signs of infection, in basal conditions (during standard bicarbonate dialysis and unselected filters: x) and after 4 months of possibly more bio ... | 2005 | 16013016 |
| localization and role of leptin in the thyroid gland of the lizard podarcis sicula (reptilia, lacertidae). | leptin, the product of the ob gene, is a hormone secreted by adipocytes that regulates food intake and energy expenditure. the hypothalamus-pituitary-thyroid axis is markedly influenced by the metabolism status, being suppressed during food deprivation. the present study was designed to ascertain whether (1) lizard thyroid gland expresses the long form of leptin receptor (ob-rb) and (2) the leptin administration affects the thyroid gland activity in this species (and to verify whether leptin pla ... | 2005 | 16013046 |
| acanthamoeba genotype t4 from the uk and iran and isolation of the t2 genotype from clinical isolates. | the majority of the keratitis-causing acanthamoeba isolates are genotype t4. in an attempt to determine whether predominance of t4 isolates in acanthamoeba keratitis is due to greater virulence or greater prevalence of this genotype, acanthamoeba genotypes were determined for 13 keratitis isolates and 12 environmental isolates from iran. among 13 clinical isolates, eight (61.5%) belonged to t4, two (15.3%) belonged to t3 and three (23%) belonged to the t2 genotype. in contrast, the majority of 1 ... | 2005 | 16014429 |
| biochemical and hormonal responses during an intercollegiate football season. | changes in biochemical indices of muscle damage and hormonal markers of stress were examined during a competitive intercollegiate football season. | 2005 | 16015144 |
| [autotransplantation of cryopreserved thyroid tissue in dogs]. | according to literature data autotransplantation of thyroid tissue for postoperative hypothyroidism remain controversial in the clinical praxis. the aim of this study was to examine the possibility of autotransplantation of cryopreserved (196 degrees c) thyroid tissue pieces in the sternocleidomastoid muscles and in the "apron" formed by the flaps of the greater omentum, and to evaluate their function postoperatively in dogs. twelve adult mongrel dogs were used in the study. total thyroidectomy ... | 2005 | 16018275 |
| [comparison of the influence of general and regional anesthesia on basic haemodynamic parameters during carotid endarterectomy]. | carotid endarterectomy (cea) is a preventive operation to reduce the incidence of embolic and thrombotic cerebral stroke. cea carries a significant perioeperartive mortality rate from stroke and myocardial infarction, which may even approach 5%. thus, anesthetic and surgical techniques are constantly under scrutiny to try to reduce this relatively high incidence of morbidity and mortality. anesthetic technique for cea is divided to general (ga) and regional (ra) anesthesia, performed by cervical ... | 2004 | 16018364 |
| site-directed mutagenesis using pfu dna polymerase and t4 dna ligase. | | 2005 | 16018545 |
| radiation therapy for high-risk prostate cancer--a review. | the term high-risk prostate cancer has been coined to encompass a group of patients with a poor prognosis (clinical stage t3/t4, or t1/t2 with psa > 20 ng/ml or gs > 8). it is estimated that 20% of patients in canada present with high-risk disease, which translates into approximately 4000 new cases each year. the optimal management approach is unclear but the standard of care in north america for this group of patients is radiation therapy (rt) with prolonged adjuvant hormonal therapy. current c ... | 2005 | 16018830 |
| the measurement of free thyroxine by isotope dilution tandem mass spectrometry. | most clinical chemistry laboratories measure free thyroxine (ft4) by an analogue (direct) method. nevertheless, the validity of analogue ft4 immunoassays has been questioned and patient's results using this approach frequently do not fit in with the clinical presentation. because of these problems we routinely send out all direct free t4's that are < 2.5th percentile and many that are > 97.5th percentile for measurement by equilibrium dialysis, the gold standard method. in approximately half of ... | 2005 | 16018881 |
| rna cleavage linked with ribosomal action. | ribonuclease ls in escherichia coli is a potential antagonist of bacteriophage t4. when t4 dmd is mutated, this rnase efficiently cleaves t4 mrnas and leads to the silencing of late genes, thus blocking t4 growth. we previously found that, when two consecutive ochre codons were placed in the open reading frame of t4 soc, rnase ls cleaved soc mrna at a specific site downstream of the ochre codons. here, we demonstrate that rnase ls cleaves soc rna at the same site even when only a single ochre co ... | 2005 | 16020788 |
| relation between the hypothalamic-pituitary-thyroid (hpt) axis and the hypothalamic-pituitary-adrenal (hpa) axis during repeated stress. | previous work has indicated that acute and repeated stress can alter thyroid hormone secretion. corticosterone, the end product of hypothalamic-pituitary-adrenal (hpa) axis activation and strongly regulated by stress, has been suggested to play a role in hypothalamic-pituitary-thyroid (hpt) axis regulation. in the current study, we sought to further characterize hpt axis activity after repeated exposure to inescapable foot-shock stress (fs), and to examine changes in proposed regulators of the h ... | 2005 | 16020927 |
| a biomechanical study of posterior spinal instrumentation using pedicle screws with and without cross-links. | it is not clear from the studies reported in the literature whether the addition of cross-links to bilateral pedicle screws increases the stiffness of the construct significantly to fix multilevel vertebral bodies. the current study addresses the question of how cross-links change the rotational stiffness of constructs with 6, 12, and 20 pedicle screws. | 2005 | 16021019 |
| expression of protease-activated receptors 1 and 2 in melanocytic nevi and malignant melanoma. | protease-activated receptors (pars) are members of the g protein-coupled receptor superfamily that are activated by the proteolytic cleavage of their amino terminal domain. par-1 activation by thrombin results in several biologic effects, including platelet adhesion to other cells or extracellular matrix, fibroblast, and endothelial cell growth, whereas par-2, activated by trypsin, has mainly a proinflammmatory and angiogenetic role. par-1 and par-2 modulate cell proliferation in physiopathologi ... | 2005 | 16021575 |
| tandem mass spectrometry of deprotonated iodothyronines. | in order to assist with the development of more selective and sensitive methods for thyroid hormone analysis the [m-h]- anions of the iodothyronines t4, t3, rt3, (3,5)-t2 and the non-iodinated thyronine (t0) have been generated by negative ion electrospray mass spectrometry. tandem mass spectra of these ions were recorded on a triple-quadrupole mass spectrometer and show a strong analogy with the fragmentation pathways of the parent compound, tyrosine. all iodothyronines also show significant ab ... | 2005 | 16021613 |
| [hypothyroid myopathy caused by interferon-alpha therapy for chronic hepatitis c]. | we reported a rare case with hypothyroid myopathy after interferon-alpha (ifn-alpha) therapy. a 59-year-old man complained of his weakness in proximal part of upper and lower extremities which started at 1 month and progressed during 6 months after ifn-alpha therapy for chronic hepatitis c, but he did not complain of any other symptoms. blood chemistry showed an elevated level of ck (1,843 iu/l; normal range 43-170 iu/l) and increased myoglobin (250 ng/ml; normal range < 60 ng/ml). thyroid funct ... | 2005 | 16022470 |
| phylogenetic analysis of canine parvovirus vp2 gene in taiwan. | canine parvovirus (cpv) is a non-enveloped virus with a single-stranded dna genome and causes infectious enteritis in dog. in this study, 36 isolates of cpv infection were obtained in taichung, taiwan from 2003 to 2004. using primers that can distinguish subtypes of cpv, we amplified part of viral vp2 gene by polymerase chain reaction (pcr) and the pcr product was sequenced; results demonstrated that two isolates could be classified as type 2a of cpv and the others were type 2b. the complete cod ... | 2005 | 16025242 |
| effect of corn silage from an herbicide-tolerant genetically modified variety on milk production and absence of transgenic dna in milk. | data from 60 multiparous holstein cows were used in a 12-wk continuous design feeding trial. cows were allocated to 1 of 4 experimental treatments (t1 to t4). in t1 and t2, the total mixed ration (tmr) contained either corn silage from the genetically modified (gm) variety chardon liberty link, which is tolerant to the herbicide glufosinate ammonium, or its near isogenic nongm counterpart, whereas the tmr used in t3 and t4 contained corn silage from the commercially available nongm varieties fab ... | 2005 | 16027202 |
| retromolar trigone carcinoma treated by primary radiation therapy: an alternative to the primary surgical approach. | to review our experience in the treatment of retromolar trigone carcinoma with radiotherapy as the primary modality and to evaluate the different factors affecting locoregional control and survival. | 2005 | 16027279 |
| effect of endoscopic thoracic sympathetic block on plantar hyperhidrosis. | endoscopic thoracic sympathetic block at t4 (esb4) provides excellent results in patients with primary hyperhidrosis (hh) of the upper limb. most patients have combined palmo-plantar or palmo-axillary-plantar hh. this study evaluates the clinical outcome of patients with upper limb hh with special emphasis on plantar sweating and patients' quality of life. | 2005 | 16027333 |
| [effects of lobectomy on the auditory mid-latency response in temporal lobe epileptic patients]. | auditory mid-latency response (mlr) has been studied in temporal lobe epileptic patients in order to evaluate the relationship between the different components of this evoked response and their probable generators in the most rostral part of auditory pathway. | 2005 | 16028185 |
| post-resection mucosal margin shrinkage in oral cancer: quantification and significance. | the importance of tumor free margins in outcome of cancer surgery is well known. often the pathological margins are reported to be significantly smaller than the in situ margins. this discrepancy is due to margin shrinkage the quantum of which has not been studied in patients with oral cancers. | 2005 | 16028286 |
| prognostic factors for persistent or recurrent disease of papillary thyroid carcinoma with neck lymph node metastases and/or tumor extension beyond the thyroid capsule at initial diagnosis. | reliable prognostic factors are needed in papillary thyroid cancer patients to adapt initial therapy and follow-up schemes to the risks of persistent and recurrent disease. objective and settings: to evaluate the respective prognostic impact of the extent of lymph node (ln) involvement and tumor extension beyond the thyroid capsule, we studied a group of 148 consecutive papillary thyroid cancer patients with ln metastases and/or extrathyroidal tumor extension. initial treatment, performed at the ... | 2005 | 16030160 |
| changes in blood levels of zinc, copper, selenium, glutathione peroxidase, vitamin b12 and total and free thyroxine in sheep removed from pasture and held without food for 50 hours. | blood was collected from a group of ten sheep immediately after removal from pasture and thereafter at regular intervals for 50 hours whilst maintaining them without food but with adequate water. the samples were analysed for parameters normally examined as an aid to the diagnosis of zinc, copper, selenium, cobalt and iodine status. serum vitamin b12 levels increased with time. mean plasma zinc concentrations and mean serum concentrations of both t4 and ft4 followed significant parabolic trends. ... | 1986 | 16031208 |
| feline hyperthyroidism--a review. | feline hyperthyroidism is the name given to the multisystemic manifestation of excessive concentrations of circulating thyroid hormones, thyroxine (t4) and tri-iodothyronine (t3). the most common cause is a functional thyroid adenoma involving one or both thyroid lobes. both multinodular adenomatous hyperplasia and multinodular adenomatous goitre are acceptable descriptions for the histopathological findings. thyroid adenocarcinoma rarely causes hyperthyroidism in the cat, and when present, seld ... | 1988 | 16031447 |
| an investigation of the possible effects of subclinical iodine deficiency on ewe fertility and perinatal lamb mortality. | a controlled supplementation trial was performed in an assumed iodine-deficient romney ewe flock in the manawatu. significantly more twin litters were born to iodine-supplemented ewes than to control ewes. furthermore, the perinatal mortality rate in lambs born to iodine-supplemented dams was significantly lower than in lambs born to control dams. ewe age and the use of different lambing paddocks for iodine-supplemented and control ewes may have been confounding factors. in both iodine-supplemen ... | 1997 | 16031990 |
| recent information on iodine deficiency in new zealand sheep flocks. | to determine the value of pasture iodine, serum thyroxine (t4) and tri-iodothyronine (t3) concentrations and thyroid (g) to body weight (kg) ratios in lambs as criteria to predict and diagnose increased litter size and decreased perinatal mortality in response to iodine supplementation. | 1998 | 16032052 |
| reporting of vertebral fractures on spine x-rays. | vertebral fractures are the hallmark of osteoporosis, responsible for increased morbidity and mortality in post-menopausal women. however, two-thirds of vertebral fractures do not come to clinical attention. the aim of this study was to compare the identification of vertebral fractures on spine x-rays among rheumatologists. study subjects were women aged 60-80 years having potential signs of vertebral fracture and visiting a rheumatologist. x-rays were performed according to standardized procedu ... | 2005 | 16032373 |
| iatrogenic fractures in ankylosing spondylitis--a report of two cases. | two cases of intraoperative, iatrogenic cervical spine fractures in patients with ankylosing spondylitis are reported. | 2006 | 16032433 |
| endoscopic ultrasound miniprobe staging of colorectal cancer: can management be modified? | miniprobe ultrasound technology allows in-vivo luminal staging of colorectal cancer with a probe that passes directly through the colonoscope's instrument port. conventional rigid radial echoscopes are limited by the need for a second examination, an inability to image stenotic lesions, and the inaccessibility of proximal tumours. since minimally invasive resection techniques are now possible, a sensitive preoperative staging tool is needed to optimize patient selection. the aim of this study wa ... | 2005 | 16032488 |
| hyperfractionated externally irradiated primary oral squamous cell carcinomas: vital tumor cells in resection specimens. | oral squamous cell carcinoma (oscc) is among the most frequent malignancies worldwide. ablative surgery for oscc is the therapy of choice, however, severe disfigurement and loss of function is a consequence of therapy. on the other hand, r0-resection margins following ablative surgery do not guarantee disease-free survival, in particular due to the widespread, interconnecting lymphatic vessels. therefore, irradiation of the primary and efferent lymphatics is a valuable therapeutic alternative to ... | 2005 | 16033087 |
| heterogeneity in prostate cancer: prostate specific antigen (psa) and dna cytophotometry. | the heterogeneity in prostate cancer is the reason for the difficult diagnosis and prognosis of this tumor. in this study, we looked for a correlation between prostate specific antigen (psa), tumor staging and dna cytophotometry. | 2005 | 16033100 |
| anterior resection of rectal cancer without bowel preparation and diverting stoma. | since the introduction of total mesorectal excision (tme) as the standard operation technique for rectal cancer, anastomotic leakage percentages of up to 18% have been reported. to prevent such leakage, the use of mechanical bowel preparation and also the construction of a diverting ileostoma or colostomy have been standard procedures for years. in our institute, however, all patients undergoing colorectal surgery are operated upon without these measures. the present study was undertaken to inve ... | 2005 | 16034541 |
| treatment of the n0 neck during salvage surgery after radiotherapy of head and neck squamous cell carcinoma. | the morbidity and mortality rates of salvage surgery in patients with local recurrence of head and neck squamous cell carcinoma (hnscc) after radiotherapy are high. the aim of this study was to determine the rate of occult neck node metastasis and the surgical morbidity of patients after salvage surgery for local relapse after definitive radiotherapy. | 2005 | 16035097 |
| the possible role of radiofrequency as complementary treatment of locally advanced gastric cancer. | the prognosis of locally advanced gastric cancer (t3-t4) is bad. the presence of lymph nodes (n3-n4) or haematogenous metastases (liver, lung) gets worse the evolution; principally the hepatic malignancies are cause of scarce survival. the possible use of a palliative treatment as radiofrequency ablation (the good results are note about the treatment of hepatic malignancies by colo-rectal cancer) is reported in recent series. therefore we decide to use radiofrequency ablation for the treatment o ... | 2005 | 16035670 |