| [an observation on long-term results of subtotal laryngectomy with preservation of an arytenoid cartilage]. | to discuss the long-term results of the subtotal laryngectomy with preservation of an arytenoids cartilage. | 2005 | 15906521 |
| association of the risk of development of hypothyroidism after iodine 131 treatment with the pretreatment pattern of sodium pertechnetate tc 99m uptake in the thyroid gland in cats with hyperthyroidism: 165 cases (1990-2002). | to assess whether the risk of development of hypothyroidism after treatment with iodine 131 (131i) was associated with the pattern of sodium pertechnetate tc 99m activity in the thyroid gland detected via scintigraphy before treatment in cats with hyperthyroidism. | 2005 | 15906566 |
| newborn screening in indonesia. | in indonesia, newborn screening is not yet a policy, and the incidence of preventable causes of mental retardation detected by newborn screening is not known. congenital hypothyroidism (ch) is not infrequent. without a screening program, unrecognized ch patients were neglected for years. since may 1999, the international atomic energy agency (iaea) has assisted in starting a ch newborn screening project to estimate the local incidence of ch and to evaluate the problems associated with the screen ... | 2003 | 15906701 |
| national neonatal hypothyroid screening program in mongolia. | this study was motivated by the desire to identify patients with congenital hypothyroidism for early treatment. a pilot project was developed by the department of nuclear medicine and initial screening was began at 2 of the maternity houses in ulaanbaatar. the methodology used for these activities involved collecting samples by heel prick at 3-4 days of age and analysed for tsh by immunoradiometric testing (skybio ltd, united kingdom). from july 2000 to september 2001, 1,529 babies were screened ... | 2003 | 15906704 |
| the utility of ft4 serum in newborns at risk for congenital hypothyroidism (ch). | thyrotropin (tsh) stimulates hormonogenesis using the iodate substrate and tyrosine amino acid. after various enzymatic reactions, thyroxine (t4) and triiodothyronine (t3) are released. part of the hormone freely circulates in serum as free t3 (ft3) and free t4 (ft4). tsh is released after feedback. a study was undertaken to determine cut-off levels of ft4 to verify hypothalamic and pitutitary hypothyroidism. both tsh and t4 were determined on blood spots by chemoluminescence and radioimmunology ... | 2003 | 15906723 |
| screening for congenital hypothyroidism--a new era in bangladesh. | neonatal screening is a new concept in bangladesh. currently a pilot program is ongoing where newborns are screened for congenital hypothyroidism (ch). in a country like bangladesh, where people are still fighting childhood problems like malnutrition, diarrhea and other communicable diseases with a high infant and child mortality rate, instituting a newborn screening program is a challenge. tsh is measured on filter paper using irma methods. both cord and heel prick blood are used. a cut off val ... | 2003 | 15906726 |
| action of human endonucleases iii and viii upon dna-containing tandem dihydrouracil. | we have shown previously that endonuclease iii from escherichia coli, its yeast homolog ntg1p and e. coli endonuclease viii recognize single dihydrouracil (dhu) lesions efficiently. however, these enzymes have limited capacities for completely removing dhu, when the lesion is present on duplex dna as a tandem lesion. a duplex 30-mer (duplex1920) containing tandem dhu lesions at positions 19 and 20 from the 5' terminus was used as a substrate for human endonuclease iii (hnth) and endonuclease vii ... | 2005 | 15907775 |
| parotid gland-sparing 3-dimensional conformal radiotherapy results in less severe dry mouth in nasopharyngeal cancer patients: a dosimetric and clinical comparison with conventional radiotherapy. | this study examined the efficacy of parotid gland sparing of three-dimensional conformal radiotherapy (3dcrt) compared with conventional radiotherapy for npc patients. both the dose given to the parotids and clinical assessment of dry mouth were conducted. | 2005 | 15908027 |
| target search of n sliding proteins on a dna. | at low to moderate ambient salt concentrations, dna-binding proteins bind relatively tightly to dna, and only very rarely detach. intersegmental transfer due to dna-looping can be excluded by applying an external pulling force to the dna molecule. under such conditions, we explore the targeting dynamics of n proteins sliding diffusively along dna in search of their specific target sequence. at lower densities of binding proteins, we find a reduction of the characteristic search time proportional ... | 2005 | 15908574 |
| interaction between the t4 helicase loading protein (gp59) and the dna polymerase (gp43): unlocking of the gp59-gp43-dna complex to initiate assembly of a fully functional replisome. | single-molecule fluorescence resonance energy transfer and functional assays have been used to study the initiation and regulation of the bacteriophage t4 dna replication system. previous work has demonstrated that a complex of the helicase loading protein (gp59) and the dna polymerase (gp43) on forked dna totally inhibits the polymerase and exonuclease activities of gp43 by a molecular locking mechanism (xi, j., zhuang, z., zhang, z., selzer, t., spiering, m. m., hammes, g. g., and benkovic, s. ... | 2005 | 15909989 |
| templated metal catalysis for single nucleotide specific dna sequence detection. | a catalytic dna-templated reaction of hydrolysis of an ester group in an n-modified peptide nucleic acid, which is activated by a cu2+ complex-pna, has been discovered and optimized. both the ester-containing pna and the metal complex pna bind neighboring sites on a template dna. this brings the reacting groups (the ester and the cu2+ complex) in proximity to each other and accelerates the hydrolysis of the ester approximately 500 times in comparison with its hydrolysis in the absence of the tem ... | 2005 | 15913375 |
| dna repair in a protein-dna complex: searching for the key to get in. | an obstacle encountered by nucleotide excision repair (ner) proteins during repair of the genome is the masking of bulky lesions by dna binding proteins. for example, certain transcription factors are known to be impediments, and suppress damage removal at their recognition sequences. we have used well-defined protein-dna complexes to study the molecular mechanism(s) used by repair proteins in gaining access to dna lesions in chromatin. using transcription factor iiia (tfiiia) and the 5s ribosom ... | 2005 | 15913668 |
| combination of his-tagged t4 endonuclease vii with microplate array diagonal gel electrophoresis for high-throughput mutation scanning. | | 2005 | 15914792 |
| effects of 900 mhz electromagnetic field on tsh and thyroid hormones in rats. | in this study, the effects of exposure to a 900 megahertz (mhz) electromagnetic field (emf) on serum thyroid stimulating hormone (tsh) and triiodothronine-thyroxin (t3-t4) hormones levels of adult male sprague-dawley rats were studied. thirty rats were used in three independent groups, 10 of which were control (without stress and emf), 10 of which were exposed to 900 mhz emf and 10 of which were sham-exposed. the exposures were performed 30 min/day, for 5 days/week for 4 weeks to 900 mhz emf. sh ... | 2005 | 15917150 |
| glucose-6-phosphate dehydrogenase deficiency in neonatal indirect hyperbilirubinemia. | the aim of this article is to investigate the prevalence of glucose-6-phosphate dehydrogenase (g6pd) deficiency in neonatal hyperbilirubinemia and to compare the clinical presentation and course of g6pd-deficient and normal patients. this study included a total of 624 term neonates with indirect hyperbilirubinemia from march 2001 to september 2004. birth weight, sex, weight at admission, serum bilirubin at admission, maximum bilirubin, phototherapy duration, duration of hospitalization and the n ... | 2006 | 15917260 |
| profile of thyroid hormones in breast cancer patients. | estrogen involvement in breast cancer has been established; however, the association between breast cancer and thyroid diseases is controversial. estrogen-like effects of thyroid hormone on breast cancer cell growth in culture have been reported. the objective of the present study was to determine the profile of thyroid hormones in breast cancer patients. serum aliquots from 26 patients with breast cancer ranging in age from 30 to 85 years and age-matched normal controls (n = 22) were analyzed f ... | 2005 | 15917958 |
| [a case of t4 esophageal squamous cell carcinoma in esophagogastric junction effectively treated by neoadjuvant fap therapy]. | a 59-year-old man was admitted to our hospital because of vomiting and body weight loss. upper gi series and upper digestive tract endoscopy revealed type 3 cancer lesion in the area from the lower thoracic esophagus to the middle gastric body. in the biopsy specimen squamous cell cancer was shown. we perfomed neoadjuvant chemotherapy because the computed tomography revealed invasion to the diaphragm and aorta. after chemotherapy a 65% reduction was obtained, and we performed total gastrectomy w ... | 2005 | 15918567 |
| the t4-encoded cochaperonin, gp31, has unique properties that explain its requirement for the folding of the t4 major capsid protein. | the morphogenesis of bacteriophage t4 requires a specialized bacteriophage-encoded molecular chaperone (gp31) that is essential for the folding of the t4 major capsid protein (gp23). gp31 is related to groes, the chaperonin of the escherichia coli host because it displays a similar overall structure and properties. why groes is unable to fold the t4 capsid protein in conjunction with groel is unknown. here we show that gp23 binds to the groel heptameric ring opposite to the ring that is bound by ... | 2005 | 15919824 |
| high prevalence of congenital hypothyroidism in the greek cypriot population: results of the neonatal screening program 1990-2000. | to evaluate the results of the screening program for congenital hypothyroidism (ch) in the greek cypriot population. | 2005 | 15921174 |
| exogenous subclinical hyperthyroidism during adolescence: effect on peak bone mass. | chronic subclinical hyperthyroidism induced by suppressive doses of l-thyroxine (l-t4) therapy, so-called exogenous subclinical hyperthyroidism, may cause diminished bone mass in postmenopausal women. the effect of subclinical hyperthyroidism during childhood and adolescence on peak bone mass, however, has not been evaluated. | 2005 | 15921175 |
| use of growth hormone and gonadotropin releasing hormone agonist in addition to l-thyroxine to attain normal adult height in two patients with severe hashimoto's thyroiditis. | we report two patients with severe acquired juvenile hypothyroidism who presented with compromised predicted adult height (pah), and the successful use of growth hormone (gh) and gonadotropin releasing hormone agonist (gnrha) in addition to l-thyroxine to attain normal adult height. | 2005 | 15921183 |
| inhibition of cell proliferation, cytotoxicity and induction of apoptosis of 1,4-bis(1-naphthyl)-2,3-dinitro-1,3-butadiene in gastrointestinal tumour cell lines and preliminary evaluation of its toxicity in vivo. | our preliminary data suggested that 1,4-bis(1-naphthyl)-2,3-dinitro-1,3-butadiene [viale m, ottone m, chiavarina b, mariggiò ma, prevosto c, dell'erba c, et al. preliminary evaluation in vitro of the inhibition of cell proliferation, cytotoxicity and induction of apoptosis by 1,4-bis(1-naphthyl)-2,3-dinitro-1,3-butadiene. invest new drug 2004;22:359-67] (naph-dnb), possesses good characteristics in terms of inhibition of cell proliferation in two cell lines derived from colon and gastric cancers ... | 2005 | 15921920 |
| inhibition of n-methyl-n-nitrosourea-induced mammary carcinogenesis by molecular iodine (i2) but not by iodide (i-) treatment evidence that i2 prevents cancer promotion. | we analyzed the effect of molecular iodine (i2), potassium iodide (ki) and a subclinical concentration of thyroxine (t4) on the induction and promotion of mammary cancer induced by n-methyl-n-nitrosourea. virgin sprague-dawley rats received short or continuous treatment. continuous i2 treated rats exhibited a strong and persistent reduction in mammary cancer incidence (30%) compared to controls (72.7%). interruption of short or long term treatments resulted in a higher incidence in mammary cance ... | 2005 | 15922087 |
| muc 1 core protein as a marker of gallbladder malignancy. | the significance of muc 1 expression in the gallbladder tissues in relation to cancer and non-cancer disease is not well understood. the aim of this study was to clarify the significance of muc 1 expression. | 2005 | 15922536 |
| prognostic utility of a semiquantitative spinal deformity index. | the semiquantitative spinal deformity index (sdi) is a summary measure of the vertebral fracture status of the spine incorporating both the number and severity of vertebral fractures. for each vertebra, a visual semiquantitative grade of 0, 1, 2, or 3 is assigned for no fracture or mild, moderate, or severe fracture, respectively, and the sdi is calculated by summing the fracture grades of all vertebrae (t4 to l4). we investigated the effect of prevalent vertebral fracture number and severity, a ... | 2005 | 15922683 |
| investigations of pyrimidine dimer glycosylases--a paradigm for dna base excision repair enzymology. | the most prevalent forms of cancer in humans are the non-melanoma skin cancers, with over a million new cases diagnosed in the united states annually. the portions of the body where these cancers arise are almost exclusively on the most heavily sun-exposed tissues. it is now well established that exposure to ultraviolet light (uv) causes not only damage to dna that subsequently generates mutations and a transformed phenotype, but also uv-induced immunosuppression. human cells have only one mecha ... | 2005 | 15923014 |
| prognostic factors in maxillary sinus and nasal cavity carcinoma. | the aim of the present study is to define prognostic factors, particularly the impact of treatment on paranasal sinus and nasal cavity malignancies. | 2005 | 15923101 |
| circulating thyroid hormone levels and iodothyronine deiodinase activities in nile tilapia (oreochromis niloticus) following dietary exposure to endosulfan and aroclor 1254. | we evaluated the effects of two organochlorinated environmental contaminants, endosulfan and aroclor 1254 on peripheral thyroid hormone metabolism and thyroid hormone plasma levels in nile tilapia (oreochromis niloticus). tilapia were exposed through diet to 0.1 and 0.5 microg g(-1) of endosulfan and 0.5 microg g(-1) of aroclor 1254 for 21 and 35 days. decreased plasma t4 and rt3 levels were observed in tilapia exposed to the lower dose of endosulfan, while treatment with a higher dose and arocl ... | 2005 | 15923148 |
| structure-function analysis of yeast trna ligase. | trl 1 is an essential 827-amino-acid enzyme that executes the end-healing and end-sealing steps of trna splicing in saccharomyces cerevisiae. trl1 consists of two catalytic domains--an n-terminal adenylyltransferase/ligase component (amino acids 1-388) and a c-terminal 5'-kinase/cyclic phosphodiesterase component (amino acids 389-827)--that can function in trna splicing in vivo when expressed as separate polypeptides. sedimentation analysis indicates that the ligase and kinase/cpd domains are mo ... | 2005 | 15923379 |
| immunohistochemical demonstration of multiple hpv types in laryngeal squamous cell carcinoma. | the aim of this study was to determine the prevalence of human papillomaviruses (hpv) types 6, 11, 16, 18, 31, 33, 42, 51, 52, 56 and 58 in laryngeal squamous cell carcinoma specimens using immunohistochemical reactions and to correlate the presence of hpv with the clinical and pathological characteristics of these patients. tissue samples were collected from 40 patients with primary laryngeal squamous cell carcinoma (lscc) and from 33 subjects with non-neoplastic laryngeal lesions or laryngeal ... | 2005 | 15924277 |
| methionine-deficient diet extends mouse lifespan, slows immune and lens aging, alters glucose, t4, igf-i and insulin levels, and increases hepatocyte mif levels and stress resistance. | a diet deficient in the amino acid methionine has previously been shown to extend lifespan in several stocks of inbred rats. we report here that a methionine-deficient (meth-r) diet also increases maximal lifespan in (balb/cj x c57bl/6 j)f1 mice. compared with controls, meth-r mice have significantly lower levels of serum igf-i, insulin, glucose and thyroid hormone. meth-r mice also have higher levels of liver mrna for mif (macrophage migration inhibition factor), known to be higher in several o ... | 2005 | 15924568 |
| short photoperiod enhances thermogenic capacity in brandt's voles. | environmental cues play important roles in the regulation of an animal's physiology and behavior. in the present study, we examined the effects of short photoperiod (sd) on body weight as well as on several physiological, hormonal, and biochemical measures indicative of thermogenic capacity to test our hypothesis that short photoperiod stimulates increases in thermogenesis without cold stress in brandt's voles. sd voles showed increases in basal metabolic rate (bmr) and nonshivering thermogenesi ... | 2005 | 15924911 |
| simultaneous determination of unbound thyroid hormones in human plasma using high performance frontal analysis with electrochemical detection. | a direct injection hplc method in combination with high-performance frontal analysis (hpfa) and electrochemical detection (ecd) was developed for the simultaneous and sensitive determination of unbound thyroid hormones (thyroxine, triiodothyronine, and reverse triiodothyronine) in human plasma. the present on-line hplc/hpfa system consists of an hpfa column, an extraction column and an analytical hplc column connected through a column-switching device, and the eluent from the analytical column w ... | 2005 | 15925209 |
| impact of intensity-modulated radiation therapy as a boost treatment on the lung-dose distributions for non-small-cell lung cancer. | to investigate the feasibility of intensity-modulated radiotherapy (imrt) as a method of boost radiotherapy after the initial irradiation by the conventional anterior/posterior opposed beams for centrally located non-small-cell lung cancer through the evaluation of dose distributions according to the various boost methods. | 2005 | 15927412 |
| electrokinetic transport of rigid macroions in the thin double layer limit: a boundary element approach. | a boundary element (be) procedure is developed to numerically calculate the electrophoretic mobility of highly charged, rigid model macroions in the thin double layer regime based on the continuum primitive model. the procedure is based on that of o'brien (r.w. o'brien, j. colloid interface sci. 92 (1983) 204). the advantage of the present procedure over existing be methodologies that are applicable to rigid model macroions in general (s. allison, macromolecules 29 (1996) 7391) is that computati ... | 2005 | 15927633 |
| multimodality treatment of esophageal cancer. | stage specific management of non-small cell lung cancer is widely accepted. the use of pretreatment disease stage to guide therapy for esophageal cancer is an intellectually appealing concept. to date, there isa relative lack of data upon which one may base stage specific treatment decisions for esophageal carcinoma. this is because thorough pretreatment tnm staging is not universally practiced. as a result, stage-specific treatment varies widely. based upon the available data, surgery alone may ... | 2005 | 15927656 |
| ovarian iodide uptake and triiodothyronine generation in follicular fluid. the enigma of the thyroid ovary interaction. | since 1928, the iodine concentration in the ovary has been known to be higher than in every other organs except the thyroid. the ovarian iodide uptake varies with sexual activities, is enhanced by estrogens and a hypothyroid state and blocked by goitrogens. the recent discovery of a sodium iodide symporter (nis) in ovaries has offered a possible mechanism for ovarian iodide uptake and other functional similarities to its thyroid counterpart. nevertheless, the physiological significance of ovaria ... | 2005 | 15927769 |
| review: treatment of hypothyroidism with combinations of levothyroxine plus liothyronine. | combined infusion of levothyroxine plus liothyronine, as opposed to levothyroxine alone, is the only way of restoring the concentrations of circulating tsh, t4, and t3 as well as those of both t4 and t3 in all tissues of thyroidectomized rats. considering the substantial differences in thyroid hormone secretion, transport, and metabolism between rats and humans, whether or not combined levothyroxine plus liothyronine replacement therapy has advantages over treatment with levothyroxine alone in h ... | 2005 | 15928247 |
| cervical osteotomy in ankylosing spondylitis: evaluation of new developments. | cervical osteotomy can be performed on patients with cervical kyphosis due to ankylosing spondylitis. this study reviews the role of two new developments in cervical osteotomy surgery: internal fixation and transcranial electrical stimulated motor evoked potential monitoring (tes-mep). | 2006 | 15928952 |
| increased proliferation activity measured by immunoreactive ki67 is associated with survival improvement in rectal/recto sigmoid cancer. | to assess the expression of ki67 as prognosticator in rectal/recto sigmoid cancer. | 2005 | 15929175 |
| is patient's age a prognostic factor for follicular thyroid carcinoma in the tnm classification system? | the knowledge of prognostic factors is essential for an optimal treatment of patients. the aim of our study was to find out if age is an independent prognostic factor for patients with follicular or hürthle cell carcinoma. this retrospective study was carried out in 261 patients (median age, 62 years) with follicular or hürthle cell thyroid carcinoma treated at our institute from 1972-2002. for all patients the follow-up was performed at our institute at least once per year. the data on gender a ... | 2005 | 15929665 |
| cardiovascular support for low birth weight infants and cerebral hemodynamics: a randomized, blinded, clinical trial. | maintaining adequate organ blood flow is the target of vasopressor treatment, but the impact of these measures on cerebral perfusion has not yet been evaluated systematically in a randomized, blinded, clinical trial. | 2005 | 15930210 |
| malnutrition and nonthyroidal illness syndrome after stroke. | in the present study, nonthyroidal illness syndrome (ntis), which is characterized by reduction of serum triiodothyronine (t3) without elevation of thyroid-stimulating hormone (tsh), was induced by protein-energy malnutrition (pcm). protein-energy malnutrition is a common condition and is associated with worse clinical outcome in stroke patients admitted to a rehabilitation service. however, little is known about ntis in stroke patients. therefore, we studied the effects of pcm and ntis on funct ... | 2005 | 15931602 |
| which young physicians are satisfied with their work? a prospective nationwide study in norway. | few studies have investigated personality and medical school variables in regard to job satisfaction after graduation. it is of great importance to investigate these factors because this information may be used in the recruitment/admittance process to medical schools, and possibly to improve medical education. | 2005 | 15932648 |
| adjuvant therapy with edrecolomab versus observation in stage ii colon cancer: a multicenter randomized phase iii study. | in a phase iii study recruiting patients with stage ii colon cancer the effect of adjuvant therapy with edrecolomab, a murine monoclonal antibody to the cell-surface glycoprotein 17-1a, was compared to observation alone. | 2005 | 15933423 |
| planned neck dissection after concomitant radiochemotherapy for advanced head and neck cancer. | since 1998, at our academic, multidisciplinary head and neck cancer treatment center, it has been our policy to treat appropriate patients with locoregionally advanced squamous cell carcinoma of the head and neck (scchn) with concomitant radiochemotherapy followed within 6 weeks by planned neck dissection(s). our objective was to investigate the oncologic efficacy of planned neck dissection, to date, in this patient population with a focus on outcomes in the neck. | 2005 | 15933512 |
| lysis-deficient bacteriophage therapy decreases endotoxin and inflammatory mediator release and improves survival in a murine peritonitis model. | lysis-deficient (lyd) bacteriophages (phages) kill bacteria without endotoxin (et) release. this may minimize systemic cytokine responses and limit inflammation in bacterial sepsis. we determined the effects of t amber a3 t4 lyd and virulent wild-type (wt) phages on mouse bacterial peritonitis. | 2005 | 15933632 |
| plasma sex steroid and thyroid hormones profile in male water frogs of the rana esculenta complex from agricultural and pristine areas. | some chemical compounds used in intensive agriculture have been found to induce estrogenic effects; therefore a histological analysis of the testes and an evaluation of plasma levels of sex steroid, thyroid hormones, and vitellogenin were carried out in adult male water frogs of two coexisting taxa (rana lessonae and the hemiclonal hybrid rana esculenta) sampled in agricultural and pristine areas. differences in seasonal profiles of hormones were found in water frogs living in the agricultural a ... | 2005 | 15935158 |
| effects of thyroid hormone on the development of immune system in zebrafish. | effects of thyroxine (t4) and methimazole (mmi) on the development of the zebrafish immune system were investigated using continuous immersion treatment experiments. the effects of the treatments on thymus development were determined using computer-aided thymus morphometric analyses on in situ hybridization serial sections of the thymus while the effects on immune-related gene expression levels were monitored using quantitative real-time pcr. the findings indicate that thymus development and thy ... | 2005 | 15935159 |
| a comparison of epidural ropivacaine 0.75% and bupivacaine 0.5% with fentanyl for elective caesarean section. | early studies suggested that ropivacaine had clinical advantages over bupivacaine with respect to cardiotoxicity and motor block, and that it was suitable for epidural caesarean section. this study was set up to compare epidural 0.75% ropivacaine with a popular bupivacaine/fentanyl mixture for elective caesarean section. | 2005 | 15935650 |
| the therapeutic value of adrenalectomy in case of solitary metastatic spread originating from primary renal cell cancer. | solitary adrenal metastases occur in about 1.2-10% of renal cell cancer patients. since the vast majority of intraadrenal lesions can be detected preoperatively, we and others have recently recommended to renounce a routine adrenalectomy during surgery of renal cell cancer. however, the impact of adrenalectomy on the patients' clinical prognosis in case of a solitary metastatic lesion within the adrenal gland remains an issue of controversial discussion. whereas some authors suggest adrenalectom ... | 2005 | 15936136 |
| intensity-modulated radiation therapy (imrt) for nasopharynx cancer: update of the memorial sloan-kettering experience. | we previously demonstrated that intensity-modulated radiation therapy (imrt) significantly improves radiation dose distribution over three-dimensional planning for nasopharynx cancer and reported positive early clinical results. we now evaluate whether imrt has resulted in improved outcomes for a larger cohort of patients with longer follow-up. | 2006 | 15936155 |
| usefulness of magnetic resonance volumetric evaluation in predicting response to preoperative concurrent chemoradiotherapy in patients with resectable rectal cancer. | we performed magnetic resonance (mr) volumetry before and after neoadjuvant chemoradiation for evaluating response to therapy in t3 and t4 rectal cancer. to investigate the utility of mr volumetry for predicting the response to neoadjuvant chemoradiation, we compared results from mr volumetry before chemoradiation with those after chemoradiation. | 2005 | 15936557 |
| effect of fasting on thyroid hormone levels, and tr(alpha) and tr(beta) mrna accumulation in late-stage embryo and juvenile rainbow trout, oncorhynchus mykiss. | the accumulation of mrna encoding for hepatic and intestinal t3-receptor (tr) and body and liver masses were measured in fed and 3-week fasted juvenile and swim up stage rainbow trout embryos. plasma and total body thyroid hormone (th) levels were measured for juvenile and swim up stages, respectively. fasted juveniles exhibited a lower hepatosomatic index (hsi), liver mass and plasma t4 and t3 concentrations than fed animals, but there were no changes in body mass or the accumulation of mrna en ... | 2005 | 15936705 |
| ileoanal pouch neoplasia in familial adenomatous polyposis: an underestimated threat. | ileal pouch-anal anastomosis is one of the two main options available for the surgical treatment of patients with familial adenomatous polyposis. its main advantage is the minimal risk of rectal cancer but a possible achilles heel is the recurrence of epithelial neoplasia at the ileal pouch-anal anastomosis and within the ileal pouch. the significance of ileoanal anastomotic and ileal pouch adenomas is not yet fully appreciated, and there is a false sense of security about this operation. the co ... | 2005 | 15937627 |
| radiotherapy alone or combined with carbogen breathing for squamous cell carcinoma of the head and neck: a prospective, randomized trial. | the current study was performed to investigate the efficacy of carbogen (95% oxygen [o(2)] and 5% carbon dioxide [co(2)]) breathing during definitive radiotherapy (rt) to enhance local control. | 2005 | 15937906 |
| an error-prone viral dna ligase. | our recent demonstration that dna polymerase x (pol x), the dna repair polymerase encoded by the african swine fever virus (asfv), is extremely error prone during single-nucleotide gap filling led us to hypothesize that it might contribute to genetic variability in asfv. for the infidelity of pol x to be relevant, however, the dna ligase working downstream of it would need to be capable of sealing nicks containing 3'-oh mismatches. we therefore examined the nick ligation capabilities of the asfv ... | 2005 | 15938630 |
| regulation of body temperature by thyrotropin-releasing hormone in neonatal chicks. | to understand thermal regulation of neonatal chicks, the contribution of thyrotropin-releasing hormone (trh), a key regulator of the hypothalamus-pituitary-thyroid axis, was investigated. intracerebroventricular (i.c.v.) injection of trh (5 and 20 microg) increased body temperature, but did not change plasma t3 and t4 concentrations. intraperitoneal (i.p.) injection of triiodothyronine (t3) and thyroxine (t4) did not influence body temperature. thereafter, the relationships between trh and the h ... | 2005 | 15939085 |
| behavioral deficits associated with fetal alcohol exposure are reversed by prenatal thyroid hormone treatment: a role for maternal thyroid hormone deficiency in fae. | children prenatally exposed to alcohol typically exhibit behavioral abnormalities, including hyperactivity, learning deficits, and an increased prevalence of depression. similar impairments are found in children of hypothyroid mothers, and we have shown that alcohol-consuming rat dams have suppressed hypothalamic-pituitary-thyroid (hpt) function. therefore, we hypothesized that suppressed maternal thyroid hormonal milieu may contribute to the deleterious consequences of prenatal alcohol exposure ... | 2005 | 15940294 |
| mechanisms associated with acanthamoeba castellanii (t4) phagocytosis. | using fluorescein isothiocyanate (fitc)-labelled escherichia coli, phagocytosis in acanthamoeba is studied. this assay is based on the quenching effect of trypan blue on fitc-labelled e. coli. only intracellular e. coli retain their fluorescence, which are easily discriminated from non-fluorescent adherent bacteria. acanthamoeba uptake of e. coli is significantly reduced in the presence of genistein, a protein tyrosine kinase inhibitor. in contrast, sodium orthovanadate (protein tyrosine phospha ... | 2005 | 15940518 |
| thyroid autoimmunity in children and adolescents with alopecia areata. | autoimmune thyroiditis (at) is often associated with alopecia areata (aa) in children and adolescents. | 2005 | 15941431 |
| development and evaluation of a gal4-mediated luc/gfp/gus enhancer trap system in arabidopsis. | gal4 enhancer trap systems driving expression of lacz and gfp reporters have been characterized and widely used in drosophila. however, a gal4 enhancer trap system in arabidopsis has not been described in the primary literature. in drosophila, the reporters possess a gal4 upstream activation sequence (uas) as five repeats (5xuas) and lines that express gal4 from tissue specific enhancers have also been used for the ectopic expression of any transgene (driven by a 5xuas). while gal4 transactivati ... | 2005 | 15941484 |
| adenylate kinase of escherichia coli, a component of the phage t4 dntp synthetase complex. | adenylate kinase, which catalyzes the reversible atp-dependent phosphorylation of amp to adp and damp to dadp, can also catalyze the conversion of nucleoside diphosphates to the corresponding triphosphates. lu and inouye (lu, q., and inouye, m. (1996) proc. natl. acad. sci. u. s. a. 93, 5720-5725) showed that an escherichia coli ndk mutant, lacking nucleoside diphosphate kinase, can use adenylate kinase as an alternative source of nucleoside triphosphates. bacteriophage t4 can reproduce in an es ... | 2005 | 15941717 |
| cardiac and renal antioxidant enzymes and effects of tempol in hyperthyroid rats. | this study evaluated the activity of cardiac and renal antioxidant enzymes [superoxide dismutase (sod), catalase (cat), glutathione peroxidase (gpx), and glutathione reductase (gr)] and whether chronic treatment with tempol, a cell membrane-permeable sod mimetic, ameliorates the hypertension of hyperthyroidism. two experiments were performed. in experiment i, the following four groups of male wistar rats were used: control group and three groups that received thyroxine (t4) at 10, 50, or 75 micr ... | 2005 | 15941780 |
| sympatho-vagal control of heart rate variability in patients treated with suppressive doses of l-thyroxine for thyroid cancer. | this study aimed to analyze the autonomic control of heart rate variability (hrv) in subjects receiving chronic l-thyroxine (l-t4) treatment after total thyroidectomy and (131)i therapy for differentiated thyroid carcinoma. | 2005 | 15941920 |
| transcriptional takeover by sigma appropriation: remodelling of the sigma70 subunit of escherichia coli rna polymerase by the bacteriophage t4 activator mota and co-activator asia. | activation of bacteriophage t4 middle promoters, which occurs about 1 min after infection, uses two phage-encoded factors that change the promoter specificity of the host rna polymerase. these phage factors, the mota activator and the asia co-activator, interact with the sigma(70) specificity subunit of escherichia coli rna polymerase, which normally contacts the -10 and -35 regions of host promoter dna. like host promoters, t4 middle promoters have a good match to the canonical sigma(70) dna el ... | 2005 | 15941982 |
| the accuracy of endoscopic ultrasonography with fine-needle aspiration, integrated positron emission tomography with computed tomography, and computed tomography in restaging patients with esophageal cancer after neoadjuvant chemoradiotherapy. | patients with esophageal cancer who receive neoadjuvant chemoradiotherapy are restaged with computed tomography (ct), endoscopic ultrasound with fine needle aspiration (eus-fna), and integrated positron emission computed tomography (fdg-pet/ct), and the results affect treatment. | 2005 | 15942562 |
| integrated computed tomography-positron emission tomography in patients with potentially resectable malignant pleural mesothelioma: staging implications. | integrated computed tomography-positron emission tomography imaging with coregistration of anatomic and functional imaging data may improve the accuracy of malignant pleural mesothelioma staging. we evaluate the use of integrated computed tomography-positron emission tomography in patients with malignant pleural mesothelioma who are being considered for extrapleural pneumonectomy. | 2005 | 15942579 |
| thyroid function in nestling tree swallows and eastern bluebirds exposed to non-persistent pesticides and p, p'-dde in apple orchards of southern ontario, canada. | this study examined the associated effects of pesticides and persistent residues of p,p'-dde on thyroid function in 16-day-old tree swallows (tachycineta bicolor) and 12-day-old eastern bluebirds (sialia sialis). apple orchards sprayed with pesticides in current use and reference sites were chosen for study in southern ontario, canada, during 2000-2001. we assessed thyroid hormone concentrations (plasma and muscle thyroxine [t4], and triiodothyronine [t3]) and the response to a challenge with th ... | 2005 | 15943111 |
| decreased type 1 iodothyronine deiodinase expression might be an early and discrete event in thyroid cell dedifferentation towards papillary carcinoma. | type i iodothyronine deiodinase (d1) catalyses the 5' monodeiodination of t4 and is highly expressed in normal human thyroid gland. we have investigated d1 expression in a series of benign and malignant differentiated thyroid neoplasias. | 2005 | 15943828 |
| [correlation of clusterin expression to prognosis of bladder carcinoma]. | clinically, molecular prognostic markers for bladder carcinoma are still rare. recently, up-regulation of clusterin protein has been suggested to relate with development and prognosis of several human cancers, but its relation with bladder cancer is unclear. this study was to analyze correlation of expression of clusterin protein to clinicopathologic parameters and prognosis of bladder cancer with tissue chip. | 2005 | 15946493 |
| [hypothyroidism following cervical irradiation in the management of carcinoma of the nasopharynx and of the breast: a prospective study on eighty-four cases]. | 1/ to evaluate the incidence of hypothyroidism following radiotherapy in the management of breast and nasopharyngeal carcinomas, 2/ to define the role of a systematic post therapeutic screening. | 2005 | 15946882 |
| exposure to bisphenol a is associated with recurrent miscarriage. | little is known about the influence of high exposure to bisphenol a on recurrent miscarriage and immunoendocrine abnormalities. | 2005 | 15947000 |
| life expectancy in differentiated thyroid cancer: a novel approach to survival analysis. | in differentiated thyroid carcinoma 10-year survival rates amount to 80-95%. because age at diagnosis varies widely, these survival rates strongly depend on age at presentation. the aim of the present study was to analyse the attributable risk factors, including therapy per se, on survival in thyroid cancer after proper adjustment for the baseline mortality rate in the general population and to elucidate the adverse treatment effects on survival. initial treatment in 504 patients consisted of th ... | 2005 | 15947102 |
| thyroid hormone receptor-beta-selective agonist gc-24 spares skeletal muscle type i to ii fiber shift. | triiodothyronine (t3) is known to play a key role in the function of several tissues/organs via the thyroid hormone receptor isoforms alpha (tralpha) and beta (trbeta). we have investigated the effects of gc-24, a novel synthetic trbeta-selective compound, on skeletal muscle fiber-type determination, cross-sectional area, and gene expression in rat skeletal muscles. for fiber typing, cross sections of soleus and extensor digitorum longus (edl) muscles were stained for myosin atpase activity at v ... | 2005 | 15947969 |
| plasma adiponectin and insulin resistance in women with polycystic ovary syndrome. | to determine plasma adiponectin concentration in women with and without polycystic ovary syndrome (pcos) and to assess possible correlations of adiponectin to the hormonal and metabolic parameters, including measures of insulin resistance (ir). | 2005 | 15950640 |
| effects of bisphenol-a (bpa), dibutylphtalate (dbp), benzophenone-2 (bp2), procymidone (proc), and linurone (lin) on fat tissue, a variety of hormones and metabolic parameters: a 3 months comparison with effects of estradiol (e2) in ovariectomized (ovx) rats. | the endocrine active substances bpa, dbp and bp2 have estrogenic effects in the uterus. proc and lin were shown to be antiandrogenic. whether other estrogen-regulated parameters like lipids, fat metabolism and hormones are also affected by these substances is unknown. we compared the effects of a 3 months lasting administration of these substances with those of e2 on an estrogen-regulated fat depot and on serum tsh, t3, t4, lh, and lipid concentrations. bp2 shared many of the effects of e2 by su ... | 2005 | 15951094 |
| elucidation of degradation mechanism of dioxins during mechanochemical treatment. | model dioxin compounds 4-chlorobiphenyl (4cb), octa-chlorodibenzo-p-dioxin (ocdd), and octachlorodibenzofuran (ocdf) were degraded by a mechanochemical (mc) process that involved milling with calcium oxide by use of a planetary ball mill. the degradation of 4cb produced mainly chloride ions and biphenyl, with the chlorine removal efficiency reaching about 100%. biphenyl was transformed into terphenyls, quaterphenyls, cyclohexylbenzene, and bicyclohexyl through polymerization and hydrogenation re ... | 2005 | 15952388 |
| the effect of cervical x-irradiation on activity index of thyrocytes and plasma tsh: a pre-clinical model for radiation-induced thyroid damage. | because radiotherapy in the head and neck region is necessary in the treatment of childhood cancer, possibilities to prevent damage to the thyroid gland must be explored. we developed a model in which radiation-induced effects can be investigated in a way that these effects can be quantified, using thyroid dysmorphology and plasma tsh. thirty-five wistar rats, 5 weeks old, were x-irradiated on the cervical region, with a single dose varying from 0 to 20 gy. after 6 weeks, tsh, t4 and t3 were det ... | 2005 | 15952412 |
| effect of long term feeding of ammoniated wheat straw treated with or without hcl on blood biochemical parameters in growing male buffalo (bubalus bubalis) calves. | twenty-four growing male buffalo calves (one year of age; 88.54 +/- 3.81 kg average body weight) were divided into three comparable groups (i, ii and iii) on the basis of their body weight (bw) in a completely randomised design to study the effect of long term feeding of ammoniated wheat straw (aws) and hydrochloric acid treated ammoniated wheat straw (hcl-aws) on blood biochemical changes. the animals were offered a concentrate mixture (cm) along with wheat straw (ws), ammoniated wheat straw (a ... | 2005 | 15952422 |
| a case of hypothyroidism and type 2 diabetes associated with type v hyperlipoproteinemia and eruptive xanthomas. | primary hypothyroidism and type 2 diabetes are both typically associated with the increased level of triglycerides. to date, there have been only a few case reports of type 2 diabetes patients with both type v hyperlipoproteinemia and eruptive xanthomas, but there have been no reports of hypothyroidism patients associated with eruptive xanthomas. we report here on a case of a 48-yr old female patient who was diagnosed with type 2 diabetes and primary hypothyroidism associated with both type v hy ... | 2005 | 15953878 |
| long-term follow-up of severely resorbed maxillary incisors after resolution of an etiologically associated impacted canine. | resorption of maxillary incisor roots because of an impacted canine is a well-recognized phenomenon that occurs in a surprisingly high proportion of patients with impacted canines. in this retrospective study, we studied a sample of patients in whom the resorption was particularly severe. | 2005 | 15953888 |
| psychogenic and pharmacologic induction of the let-down reflex can facilitate breastfeeding by tetraplegic women: a report of 3 cases. | although an increasing number of women are becoming pregnant and rearing children after spinal cord injury (sci), scant literature exists on breastfeeding after injury. in particular, it is unclear whether women with sci above t7 can sustain breastfeeding in a manner similar to neurologically intact nursing mothers. a functional let-down reflex is required to provide adequate milk to a nursing infant. infant suckling activates tactile receptors in the breast, and this signal is carried via affer ... | 2005 | 15954070 |
| decreased expression of retinoid nuclear receptor (rar alpha and rar gamma) mrna determined by real-time quantitative rt-pcr in peripheral blood mononuclear cells of hypothyroid patients. | in vivo assessment of the cellular impact of thyroid hormones on target tissues might be of help for physiological studies and to evaluate the consequences of various diseases of the thyroid gland in humans. given the tenuous relationship between retinoid and tri-iodothyronine (t3) status and that retinoids have also intracellular roles, the aim of this study was to determine the effect of hypothyroidism on the expression of t3 nuclear receptors (tr) and retinoic acid nuclear receptors (rar, rxr ... | 2005 | 15956352 |
| expression of recombinant membrane-bound type i iodothyronine deiodinase in yeast. | the bioactivity of thyroid hormone is determined to a large extent by the monodeiodination of the prohormone thyroxine (t4) by the hepatic selenoenzyme type i iodothyronine deiodinase (d1), i.e. by outer ring deiodination (ord) to the active hormone triiodothyronine (t3) or by inner ring deiodination (ird) to the inactive metabolite reverse t3 (rt3). since d1 is a membrane-bound protein with an n-terminal membrane-spanning domain, the enzyme is very difficult to purify in an active state. this s ... | 2005 | 15956354 |
| effect of daidzein on egg-laying performance in shaoxing duck breeders during different stages of the egg production cycle. | the effect of a phyto-oestrogen, daidzein, on the laying performance of shaoxing female ducks was examined in three experiments performed at different stages of the egg production cycle. egg-laying rate, egg weight, egg composition, feed conversion ratio, hatchability characteristics of eggs and body weight, ovary and oviduct weight, as well as changes in serum concentrations of t3, t4 and e2 were recorded as response criteria. in the first experiment, 68 young ducks, 100 d of age, were given a ... | 2005 | 15957437 |
| patterns of allelic loss of synchronous adenocarcinomas of the lung. | distinction of multiple primary lung carcinomas from intrapulmonary metastases using empiric clinical and histopathologic criteria can be difficult. recent advances have provided several molecular markers that can be used for clonal analysis of separate tumor nodules and enhance tumor staging and subsequent treatment and prognosis. to address this issue, we performed a microdissection-based allelotyping of 20 cases of histologically similar, pathologic stage t4 adenocarcinomas (adcs). loss of he ... | 2005 | 15958854 |
| pedicle screw placement in the thoracic spine: a comparison of image-guided and manual techniques in cadavers. | a cadaveric study comparing image guidance technology to fluoroscopic guidance as a means of pedicle screw placement in the thoracic spine, using a unique starting point for screw placement. | 2005 | 15959355 |
| dimethoate effects on thyroid function in suckling rats. | the aim of our work is to study dimethoate effects on thyroid function given in drinking water (40 mg/kg body weight, equivalent to 0.2 g/l) to mothers from day zero until the 10th day after delivery. pups and their mothers were sacrificed on day ten after parturition. compared to a control group, dimethoate-treated pups showed a 48% decrease in body weight which could be attributed to a defect in thyroid hormones. indeed, after treatment by dimethoate, plasma rates of free t4 and t3 decreased b ... | 2005 | 15959409 |
| analysis of extrahepatic bile duct carcinomas according to the new american joint committee on cancer staging system focused on tumor classification problems in 222 patients. | although the sixth edition of the american joint committee on cancer (ajcc) staging system for extrahepatic bile duct carcinoma was updated, the system has a problem on t classification due to its ambiguous definition of t1 as "tumor confined to bile duct histologically" and t2 as "tumor invading beyond the bile duct." | 2005 | 15959914 |
| carcinoma of the external auditory canal. | carcinoma of the external auditory canal is one of the most inaccessible areas of the body. it is a rare malignant neoplasm with an aggressive nature and an overall poor prognosis. in a ten year period, 16 patients were treated in king chulalongkorn memorial hospital. from tnm staging proposed by the university of pittsburgh, the authors found t1 = 1, t2 = 6, t3 = 5, t4 = 4 cases. in 14 patients who were operated on (radical mastoidectomy in 8, lateral temporal bone resection in 5, sleeve resect ... | 2005 | 15960229 |
| endocrine function in abetalipoproteinemia: a study of a female patient of greek origin. | to investigate the pituary, genitalia, adrenal, thyroid, parathyroid and pancreatic endocrine function of a female patient aged 37 with abetalipoproteinemia at the time of diagnosis and 5 years thereafter (after application of a modified diet). subject-methods: serum concentrations of cortisol, a4, acth, aldosteron, renin, dehydroepiandrosterone sulfate (dhea-5), progesterone, 17-oh progesterone, testosterone, sh13g, estradiol, luteinizing hormone, follicle stimulating hormone, t3, t4, tsh, ft3, ... | 2004 | 15960365 |
| distance between the skin and the thoracic paravertebral space. | a fundamental requirement for the safe and effective performance of paravertebral blockade is reliable estimates of the depth from skin to paravertebral space at different thoracic levels. this distance was assessed using a nerve stimulator guided paravertebral blockade technique in 527 separate blocks in 186 patients scheduled for various surgical procedures on the trunk. the median skin-paravertebral depth was 55.0 mm. the skin-paravertebral distance at upper (t1-3) and lower (t9-12) thoracic ... | 2005 | 15960719 |
| reduction in vertebral fracture risk in teriparatide-treated postmenopausal women as assessed by spinal deformity index. | teriparatide is the first bone-building drug available for the treatment of osteoporosis. we investigated the efficacy of this compound as assessed by spinal deformity index (sdi) using data from the fracture prevention trial (fpt). the fpt was a randomized, double blind trial of placebo versus teriparatide 20 microg (tptd20) versus teriparatide 40 microg (tptd40) administered by daily self-injection. patients included in the current analyses were those patients from the placebo (n = 398) and tp ... | 2005 | 15961357 |
| clinical impact of criteria for complete response (cr) of primary site to treatment of esophageal cancer. | with the development of chemoradiotherapy for esophageal cancer, the complete response (cr) rate would become an important surrogate end-point. however, the response evaluation criteria in solid tumors (recist) do not provide criteria for a response at the primary site of esophageal cancer. the objective of this study was to assess the validity of the endoscopic cr criteria for the primary site of esophageal cancer treated with chemoradiotherapy. | 2005 | 15961436 |
| real-time investigation of nucleic acids phosphorylation process using molecular beacons. | phosphorylation of nucleic acids is an indispensable process to repair strand interruption of nucleic acids. we have studied the process of phosphorylation using molecular beacon (mb) dna probes in real-time and with high selectivity. the mb employed in this method is devised to sense the product of a 'phosphorylation-ligation' coupled enzyme reaction. compared with the current assays, this novel method is convenient, fast, selective, highly sensitive and capable of real-time monitoring in a hom ... | 2005 | 15961728 |
| [transitional cell carcinoma of the upper urinary tract new concepts in management]. | transitional cell carcinomas of the upper urinary tract (uut-tccs) are rare: they account for approximately 5% of all urothelial carcinomas. 30% of patients with uut-tcc have a history of bladder tcc, but fewer than 2% of patients with bladder tcc have uut-tcc. tumor microsatellite instability (msi) is an indicator of the clonal expansion of neoplasms; it was first identified in tumors from patients with hereditary non-polyposis colorectal carcinoma (hnpcc). uut-tcc occurs in 5% of patients with ... | 2005 | 15962502 |
| evaluation of analytical methods and workflow performance of the architect ci8200 integrated serum/plasma analyzer system. | the architect ci8200 is an integrated serum analyzer for photometric, electrochemical and immunological assays. several assays of each category and the workflow performance of the system were compared with established laboratory procedures in two laboratories. | 2005 | 15963793 |
| acanthamoeba isolates belonging to t1, t2, t3, t4 but not t7 encyst in response to increased osmolarity and cysts do not bind to human corneal epithelial cells. | acanthamoeba is an opportunistic protozoan that is widely distributed in the environment and can cause human infections. the life cycle of acanthamoeba consists of an infective trophozoite form. however under harsh environmental conditions trophozoites differentiate into a double-walled, metabolically inactive and resistant cyst form. research in acanthamoeba has mostly focussed on the infective trophozoite form and its pathogenic mechanisms. in this study, we used acanthamoeba isolates belongin ... | 2005 | 15963936 |
| a new index of flat breaststroke propulsion: a comparison of elite men and women. | this study examined arm and leg coordination and propulsion during the flat breaststroke in nine elite male and eight elite female swimmers over three race paces (200 m, 100 m and 50 m). coordination was expressed using four temporal gaps (t1, t2, t3, t4), which described the continuity between the propulsive phases of the limbs, as recorded on a video device (50 hz). glide duration was denoted t1, the time between the beginning of arm and leg recovery was denoted t2, the time between the end of ... | 2005 | 15966349 |