| nongenomic effect of thyroid hormone on free-radical production in human polymorphonuclear leukocytes. | over the past few years increasing evidence has suggested the nongenomic effects of thyroid hormone, such as the activation of the signal transduction pathways and the activation of nuclear factor-kappab by the induction of oxidative stress. the present study was undertaken to investigate the effect of thyroid hormone on human polymorphonuclear leukocytes (pmnls) which are known as important sources of reactive oxygen species in the circulation. the production of superoxide anion (o2-) and the a ... | 2005 | 15817833 |
| endogenous immune response to gangliosides in patients with confined prostate cancer. | our study investigated whether endogenous igm antibodies to gangliosides occur in patients with early stages of prostate cancer (cap) patients, after defining ganglioside profiles of cap cell lines. immune and resorcinol staining detected the presence of gangliosides gm3, gm2, gd3, gd2 and gd1a but not gm1a, gd1b or gt1b in the extracts of normal prostatic epithelial cells (prec) and neoplastic androgen-insensitive (pc-3, du145) and -sensitive (lncap-fgc and lncap-fgc-10) cap cells. using a sens ... | 2005 | 15818621 |
| expression of helicobacter pylori alpa protein and its immunogenicity. | to construct a recombinant strain which expresses adhesin alpa of helicobacter pylori (h pylori) and to study the immunogenicity of adhesin alpa. | 2005 | 15818736 |
| physostigmine for the prevention of postanaesthetic shivering following general anaesthesia - a placebo-controlled comparison with nefopam. | physostigmine was studied for its efficacy in the prevention of postanaesthetic shivering compared to nefopam and placebo. we studied 89 patients undergoing abdominal and urological surgery. the study was randomised and double-blind, the patients received physostigmine 2 mg (n = 31), nefopam 10 mg (n = 30) or saline (n = 28). haemodynamic parameters and temperature were measured at induction of anaesthesia (t0), and 5 min (t1), 15 min (t2), 30 min (t3) and 60 min (t4) after reaching the postanae ... | 2005 | 15819761 |
| dietary yeast rna supplementation reduces mortality by aeromonas hydrophila in rohu (labeo rohita l.) juveniles. | a feeding trial was conducted for 60 days to delineate the effect of dietary ribonucleic acid or chitin on haematological parameters, phagocyte respiratory burst and resistance to aeromonas hydrophila of labeo rohita juveniles. one hundred and twenty-six (avg. wt. 13.40 +/- 0.17 g) juveniles were randomly distributed in six treatment groups, each one in three replicates. six isonitrogenous (crude protein: 34.34-35.37%) and isocaloric (414-425 kcal 100 g(-1)) purified diets were prepared with dif ... | 2005 | 15820128 |
| [male breast cancer: about 123 cases collected at the institute salah-azaiz of tunis from 1979 to 1999]. | male breast cancer is rare compared to its female counterpart representing less than 1% of cancer in men. the objective of our retrospective study is to report the epidemiologic and clinical profile and to analyse the therapeutic results and prognostic factors in a tunisian population collected during a period of 20 years at a single institution. we collected from 1979 to 1999, all the histological confirmed male breast cancers treated at our institution. we analyse the following data: age, clin ... | 2005 | 15820923 |
| [prevalence of minimal thyroid deficiency (subclinical hypothyreosis) and subclinical thireotoxicosis among females of average and elderly ages who hadn't been examined before]. | adjara is a region in georgia with high level at iodine deficiency. the research has been carried out to find subclinical dysfunctions of thyroid gland in women older than 40 years whose thyroid state hadn't been examined before. from 1998 to 2004 583 women aged 40-78 had been examined. primary examination was done by different specialists. all women were tested on thyreotropic hormone (tsh) by means of immunodiagnostic unit "digiscan sd-1000" (austria). examination of thyroid gland on the unit ... | 2005 | 15821322 |
| surgical intervention for t4 lung cancer with infiltration of the thoracic aorta: are we back to the archetype of surgical thinking? | | 2005 | 15821636 |
| ectopic expression of a soybean phytase in developing seeds of glycine max to improve phosphorus availability. | a transgenic approach was used to alter soybean seed phytate content by expressing a soybean phytase gene (gmphy) during seed development to degrade accumulating phytic acid (ip6). an expression vector containing the soybean phytase cdna controlled by the seed-specific beta-conglycinin promoter (alpha'-subunit) was used to transform embryogenic soybean cultures. plants from four independent transgenic lines were analyzed for transgene integration and seed ip6 levels. the reduction in ip6 levels ... | 2004 | 15821988 |
| herbicide-induced changes in charge recombination and redox potential of q(a) in the t4 mutant of blastochloris viridis. | to gain new insights into the function of photosystem ii (psii) herbicides dcmu (a urea herbicide) and bromoxynil (a phenolic herbicide), we have studied their effects in a better understood system, the bacterial photosynthetic reaction center of the terbutryn-resistant mutant t4 of blastochloris (bl.) viridis. this mutant is uniquely sensitive to these herbicides. we have used redox potentiometry and time-resolved absorption spectroscopy in the nanosecond and microsecond time scale. at room tem ... | 2005 | 15823053 |
| specific binding of poly(adp-ribose) polymerase-1 to cruciform hairpins. | poly(adp-ribose) polymerase-1 (parp-1) participates in dna cleavage and rejoining-dependent reactions, such as dna replication, recombination and repair. parp-1 is also important in transcriptional regulation, although the determinants for its binding to undamaged genomic dna have not been defined. previously, we have shown by low-resolution mapping that parp-1 may bind to the cruciform-forming regions of its own promoter. here, using dnase i and nuclease p(1) footprinting and atomic force micro ... | 2005 | 15826658 |
| efficacy and tolerability of radiotherapy as treatment for bicalutamide-induced gynaecomastia and breast pain in prostate cancer. | to assess the efficacy and tolerability of localised radiotherapy for the treatment of bicalutamide ('casodex''casodex' is a trademark of the astrazeneca group of companies.)-induced gynaecomastia and/or breast pain. | 2004 | 15826748 |
| [intraspinal air, a rare complication of blunt chest trauma]. | pneumorachis, defined as the presence of air within the spinal canal, has rarely been described, and is exceptionally due to thoracic trauma. we report the case of a 37-year-old patient who sustained a motor vehicle accident. the chest ct-scan showed a bilateral-hemothorax, a small right pneumothorax, rib fractures, and a fracture of the fourth thoracic vertebra associated with air in the spinal canal extending from t6 to l2. the fracture of t4 associated with the pleural lesion is probably resp ... | 2005 | 15826793 |
| three prochlorococcus cyanophage genomes: signature features and ecological interpretations. | the oceanic cyanobacteria prochlorococcus are globally important, ecologically diverse primary producers. it is thought that their viruses (phages) mediate population sizes and affect the evolutionary trajectories of their hosts. here we present an analysis of genomes from three prochlorococcus phages: a podovirus and two myoviruses. the morphology, overall genome features, and gene content of these phages suggest that they are quite similar to t7-like (p-ssp7) and t4-like (p-ssm2 and p-ssm4) ph ... | 2005 | 15828858 |
| pull-out strength of the suprapedicle claw construct: a biomechanical study. | the pull-out of the superior screw is a well recognized problem in anterior instrumentation of the spine for scoliosis. a biomechanical pull-out study of anterior vertebral body screw in cadaveric thoracic spine was therefore designed to investigate and compare the pull-out strength of three different anterior vertebral body fixations using the ao universal spine system: simple bicortical screw, bicortical screw with an opposite washer (sometimes called pull-out resistant nut), and a new constru ... | 2005 | 15830212 |
| impact of colloid response on survival after preoperative radiotherapy in locally advanced rectal carcinoma. | neoadjuvant therapy for rectal carcinoma modifies morphology and natural history of the tumor. colloid response defined by predominant colloid changes with or without residual tumor cells is a form of tumor response whose impact on survival is unknown. this study evaluated influence of tumor histologic response, especially of colloid response, on survival in patients treated by long-course preoperative radiotherapy for rectal cancer. in 200 patients with ut3-t4 or n1 rectal carcinomas, influence ... | 2005 | 15832083 |
| barriers to coliphage infection of commensal intestinal flora of laboratory mice. | growth characteristics of coliphage viruses indicate that they are adapted to live with their eschericia coli hosts in the intestinal tract. however, coliphage experimentally introduced by ingestion persist only transiently if at all in the gut of humans and other animals. this study attempted to identify the barriers to long term establishment of exogenous coliphage in the gastrointestinal (gi) tracts of laboratory mice. intestinal contents were screened for the presence of coliphage and host b ... | 2005 | 15833115 |
| prognostic value of lymphovascular invasion in transitional cell carcinoma of upper urinary tract. | to elucidate the prognostic significance of lymphovascular invasion (lvi) in patients with upper tract transitional cell carcinoma. | 2005 | 15833510 |
| dysprealbuminemic hyperthyroxinemia in a patient with hyperthyroid graves disease. | rare mutant forms of circulating albumin and prealbumin [transthyretin (ttr)] have increased binding affinity for thyroxine (t4). patients with these variant plasma proteins, as a result of inherited mutations or as a paraneoplastic phenomenon, typically present with increased serum total t4 and, by some assay methodologies, an increased free t4 as well. although these individuals are, in fact, euthyroid, nonspecific symptoms may lead to inappropriate treatment for hyperthyroidism. we present a ... | 2005 | 15833783 |
| lateral vertebral assessment: a valuable technique to detect clinically significant vertebral fractures. | although many vertebral fractures are clinically silent, they are associated with increased risk for subsequent osteoporotic fractures. a substantial number of these fractures are demonstrable using instant vertebral assessment with hologic densitometers. whether similar recognition is possible using dual-energy lateral vertebral assessment (lva) with ge lunar densitometers remains uncertain. thus, we evaluated the ability of clinicians using lva to detect prevalent vertebral fractures. dual-ene ... | 2005 | 15834512 |
| the body mass index and level of resection: predictive factors for compensatory sweating after sympathectomy. | compensatory sweating (cs) is the most common adverse event and the main cause of dissatisfaction among patients undergoing a vats sympathectomy for the treatment of primary hyperhidrosis. it has been described that obese individuals experience more sweating than thinner ones. the aim of this study is to identify the body mass index (bmi) and the level of resection as predictive factors for cs and its relation to levels of patient satisfaction following the procedure. | 2005 | 15834768 |
| telomerase activity in urine sediments as a tool for noninvasive detection of bladder cancer. | telomerase is extensively investigated as potential diagnostic and prognostic marker in human tumors. in this study, we determined telomerase activity in histological specimens and voided urine of 52 human bladder cancers. using the pcr-elisa method telomerase activity was found in 21 (88%) of the 24 tumor tissues and in the corresponding sediments from voided urine of patients with superficial bladder carcinoma (ta/t1). in case of muscle-invasive tumors (t2-t4), telomerase activity was found in ... | 2005 | 15837544 |
| the genome of s-pm2, a "photosynthetic" t4-type bacteriophage that infects marine synechococcus strains. | bacteriophage s-pm2 infects several strains of the abundant and ecologically important marine cyanobacterium synechococcus. a large lytic phage with an isometric icosahedral head, s-pm2 has a contractile tail and by this criterion is classified as a myovirus (1). the linear, circularly permuted, 196,280-bp double-stranded dna genome of s-pm2 contains 37.8% g+c residues. it encodes 239 open reading frames (orfs) and 25 trnas. of these orfs, 19 appear to encode proteins associated with the cell en ... | 2005 | 15838046 |
| common viral infection affects pentabrominated diphenyl ether (pbde) distribution and metabolic and hormonal activities in mice. | a murine model infection with the human coxsackievirus b3 (cb3) has been shown to change uptake and tissue distribution of several environmental pollutants, in some cases followed by an aggravated disease. in this study, the model was tested for polybrominated diphenyl ethers (pbdes), which we know are absorbed from the gastro-intestinal tract and further distributed throughout the body. on day 0, female balb/c mice were infected with cb3; on day 1 of the infection, they were dosed orally with a ... | 2005 | 15840429 |
| thyroglobulin increment after thyroid hormone withdrawal is a reliable indicator for the detection of significant remnants or metastases in patients with differentiated thyroid carcinoma. | serum thyroglobulin (tg) measurement has a pivotal role in the management of differentiated thyroid carcinoma (dtc). serum tg increment after thyroid hormone discontinuation seems to be a better predictor of tumor recurrence, however, minimal tg increment may not be a specific marker. this study tries to evaluate the importance of different levels of tg increment after thyroid hormone discontinuation. fifty-five patients (46 females and 9 males with mean age of 41.40 yrs) with dtc, treated with ... | 2004 | 15841300 |
| the non-thyroidal illness syndrome after coronary artery bypass grafting: a 6-month follow-up study. | the non-thyroidal illness syndrome (ntis) is considered a transient and completely reversible phenomenon, but it has been shown that it may last for several days postoperatively after coronary artery bypass grafting (cabg) surgery. this study was undertaken to assess thyroid function 6 months after uncomplicated cabg. the thyroid profile was evaluated in 40 consecutive patients undergoing cabg preoperatively, at 0, 12, 48, and 120 h postoperatively, and at 6-month follow-up. triiodothyronine (t3 ... | 2005 | 15843233 |
| extended multiorgan resection for t4 gastric carcinoma: 25-year experience. | in locally advanced gastric carcinoma infiltrating adjacent organs, an extended resection including invaded organs is required to improve the prognosis. we retrospectively analyzed our experience with extended multiorgan resection (emr) in patients with advanced gastric cancer. | 2005 | 15844189 |
| gains and losses of hla class ii (dr) and cd4 in atypical hyperplasia, carcinoma in situ and infiltrating ductal carcinoma of the breast. | breast cancer is a frequent cause of death among women with gynaecologic malignancies despite the introduction of combination chemotherapy. there is therefore a need for new therapeutic strategies for patients with breast cancer, such as cellular immunotherapy. in this immunohistochemical study we analyzed the epithelial expression of major histocompatibility complex (mhc) class ii (hla-dr) on atypical and malignant primary mammary epithelial cells, as well as the magnitude of the stromal t lymp ... | 2004 | 15844251 |
| new thyroxine treatment in older adults beginning lithium therapy: implications for clinical practice. | the authors sought to determine the incidence of lithium-induced hypothyroidism in a population-based cohort of older adults beginning lithium therapy and thereby to inform clinical guidelines on the frequency of monitoring necessary in this group. | 2005 | 15845755 |
| a case of stunning of lung and bone metastases of papillary thyroid cancer after a therapeutic dose (3.7 gbq) of 131i and review of the literature: implications for sequential treatments. | thyroid stunning is usually defined as the inhibition or suppression of iodide trapping by remnant thyroid tissue or by functioning metastases following a diagnostic dose of 131i. the risk of stunning increases progressively with larger doses. because the threshold above which this effect occurs in thyroid remnants seems to be between 37 mbq and 111 mbq of 131i, therapeutic 131i doses of 3.7 gbq may cause stunning. we describe stunning of papillary thyroid cancer lung and bone metastases after a ... | 2005 | 15845937 |
| monitoring macromolecular complexes involved in the chaperonin-assisted protein folding cycle by mass spectrometry. | we have used native mass spectrometry to analyze macromolecular complexes involved in the chaperonin-assisted refolding of gp23, the major capsid protein of bacteriophage t4. adapting the instrumental methods allowed us to monitor all intermediate complexes involved in the chaperonin folding cycle. we found that groel can bind up to two unfolded gp23 substrate molecules. notably, when groel is in complex with the cochaperonin gp31, it binds exclusively one gp23. we also demonstrated that the fol ... | 2005 | 15846365 |
| why to start the concomitant boost in accelerated radiotherapy for advanced laryngeal cancer in week 3. | we analyzed toxicity and the local control rates for advanced laryngeal cancer, treated with two accelerated fractionation schedules. the main difference between the schedules was the onset of the concomitant boost, in week 3 or week 4. overall treatment time and total dose were equivalent. | 2005 | 15850903 |
| dual mechanisms whereby a broken rna end assists the catalysis of its repair by t4 rna ligase 2. | t4 rna ligase 2 (rnl2) efficiently seals 3'-oh/5'-po4 rna nicks via three nucleotidyl transfer steps. here we show that the terminal 3'-oh at the nick accelerates the second step of the ligase pathway (adenylylation of the 5'-po4 strand) by a factor of 1000, even though the 3'-oh is not chemically transformed during the reaction. also, the terminal 2'-oh at the nick accelerates the third step (attack of the 3'-oh on the 5'-adenylated strand to form a phosphodiester) by a factor of 25-35, even th ... | 2005 | 15851476 |
| is the vascular system a main target for thyroid hormones? from molecular and biochemical findings to clinical perspectives. | the cardiovascular system is an important target for thyroid hormones (ths). until recently, our understanding of the biological role of ths has been largely based on a catalog of effects observed in excess or deficiency of ths. in the last decades, however, some important progress has been done in defining the molecular and biochemical basis of thyroid hormone action at the cellular and nuclear level. most of the molecular and cellular mechanisms responsible for the effects of ths on the heart ... | 2005 | 15853633 |
| the effect of combination therapy with propylthiouracil and cholestyramine in the treatment of graves' hyperthyroidism. | the study aims to evaluate the efficacy of combination therapy with propylthiouracil (ptu) and cholestyramine in the treatment of graves' hyperthyroidism. | 2005 | 15853819 |
| resection of locally advanced (t4) non-small cell lung cancer with cardiopulmonary bypass. | resection of t4 non-small cell lung cancer (nsclc) on cardiopulmonary bypass (cpb) has rarely been reported in the literature. hence, we have reviewed our experience in the role of cpb for the surgical treatment of locally advanced nsclc. | 2005 | 15854956 |
| reduced tumor vessel density and high expression of glucose transporter 1 suggest tumor hypoxia of squamous cell carcinoma of the esophagus surviving after radiotherapy. | squamous cell carcinoma of the esophagus (escc) is radiosensitive; however, surgeons frequently encounter escc that survives radiotherapy to grow more rapidly and invasively. this alteration of tumor behavior may result from tumor hypoxia induced by radiotherapy. | 2005 | 15855926 |
| multilevel vertebral hemangiomas: two episodes of spinal cord compression at separate levels 10 years apart. | this case report presents a 66-year-old woman with multiple vertebral hemangiomas causing spinal cord compression at different levels with a long symptom-free interval between episodes of compression. she presented with back pain and progressive weakness and numbness in her lower limbs for 3 months. ten years earlier, she had had a symptomatic t4 vertebral hemangioma operated successfully, and had made a full recovery. magnetic resonance imaging (mri) of the thoracic and lumbar spine revealed mu ... | 2005 | 15856339 |
| [investigation of periodic distributions of amino acids in the sequences of fiber proteins of bacteriophage t4]. | sequences of amino acids of some fiber proteins may have a periodic structure. to analyze this periodicity fourier transform of a mathematical image of symbolic sequence of amino acids in a protein is sometimes used. in this work we employed one (out of few possible) particular way of doing fourier transform as the most straightforward and optimal. employing this optimal fourier transform method we analyzed periodicity of fiber proteins in bacteriophage t4. as a result we managed to confirm that ... | 2005 | 15856956 |
| dissociation of clinical and laboratory diagnosis in hypothyroidism. | to assess the significance of clinical versus biochemical diagnosis of hypothyroidism using a clinical scoring index and optimize the therapeutic dose of levothyroxine in indian patients. | 2005 | 15857005 |
| orthodontic treatment in a patient with papillon-lefèvre syndrome. | report of a combined periodontal and orthodontic treatment in a patient with papillon-lefevre syndrome (pls). | 2005 | 15857107 |
| neonatal screening for congenital hypothyroidism in west black sea area, turkey. | the aim of this study was to investigate the incidence of congenital hypothyroidism (ch) in the west black sea area, a mild-to-moderate iodine deficient area in turkey. neonatal screening for ch was performed using blood specimens collected onto filter paper. thyrotropin [thyroid-stimulating hormone (tsh)] was measured by radioimmunoassay, and a value >20 microu/ml was considered as cut-off point for re-examining. venous serum was obtained to measure tsh, thyroxin (t4), free t4 (ft4) and thyrogl ... | 2005 | 15857333 |
| whole plasmid mutagenic pcr for directed protein evolution. | protein function can be engineered through iterated cycles of random mutagenesis and screening (directed evolution). optimization of protein expression is essential for the development of sensitive and precise high throughput assays. here we optimize the performance of a plasmid-borne escherichia coli lacz gene in two rounds of directed evolution. first, its promoter was "randomized" by whole plasmid polymerase chain reaction (pcr) and intra-molecular self-ligation. a genetically stable constitu ... | 2005 | 15857786 |
| screening for thyroid disease in pregnancy. | although gestational hyperthyroidism is uncommon (0.2%), hypothyroidism (autoimmune disease or suboptimal iodine intake) occurs in 2.5% of women and is predictive of reduced neonatal and child neuropsychological development and maternal obstetric complications. postpartum thyroid dysfunction (pptd) occurs in 5-9% of women and is associated with antithyroid peroxidase antibodies (antitpoab) in 10% of women in early pregnancy. therefore, screening for thyroid dysfunction in pregnancy should be con ... | 2005 | 15858112 |
| [molecular-genetic aspects of congenital hypothyroidism]. | congenital hypothyroidism manifests a complex of symptoms caused by a total lack or significant deficiency of thyroxine (t4) and triiodothyronine (t3) in foetal life and in the first years of child's life. the incidence of congenital hypothyroidism is 1 per 3000-4000 newborns in the world and l per 4800 in poland. there are two main causes of congenital hypothyroidism: defects of thyroid development (about 90%), defects of thyroid hormones biosynthesis (~10%), and the more seldom occurring defec ... | 2004 | 15858240 |
| use of dna repair enzymes in electrochemical detection of damage to dna bases in vitro and in cells. | electrochemical measurements at mercury or solid amalgam electrodes offer a highly sensitive detection of dna strand breaks. on the other hand, electrochemical detection of damage to dna bases at any electrode is usually much less sensitive. in this paper, we propose a new voltammetric method for the detection of the dna base damage based on enzymatic conversion of the damaged dna bases to single-strand breaks (ssb), single-stranded (ss) dna regions, or both. supercoiled dna exposed to uv light ... | 2005 | 15859612 |
| phosphorus adsorption on natural sediments: modeling and effects of ph and sediment composition. | the classic langmuir isotherm equation was modified to describe phosphorus (p) adsorption on p-polluted sediments. the p adsorption characteristics of six sediment samples from chinese taihu lake were studied by short-term isotherm batch experiments and related to sediment composition. the maximum p adsorption capacities (pac) and p-binding energy constant (k) were obtained by nonlinearly fitting sorption data using the modified langmuir isotherm model. native adsorbed exchangeable phosphorus (n ... | 2005 | 15862324 |
| ontogeny of the thyroid hormones and cortisol in the gilthead sea bream, sparus aurata. | the aim of the study was to elucidate the pattern of changes in the whole body concentrations of thyroid hormones (th) and cortisol in eggs, pre-larvae, and larvae in the gilthead sea bream, sparus aurata. the ontogeny of these hormones was related to specific morphological characteristics that characterize early development. th and cortisol were detected in substantial amounts in the eggs of sea bream. t3 concentration in eggs was found to be higher than that of t4 (t3, 4.02+/-0.38 ng g-1; t4, ... | 2005 | 15862562 |
| acetylation of nuclear hormone receptor superfamily members: thyroid hormone causes acetylation of its own receptor by a mitogen-activated protein kinase-dependent mechanism. | because the androgen and estrogen nuclear hormone receptors are subject to acetylation, we speculated that the nuclear thyroid hormone receptor-beta1 (trbeta1), another superfamily member, was also subject to this posttranslational modification. treatment of 293t cells that contain trbeta1(wt) with l-thyroxine (t4)(10(-7)m, total concentration) resulted in the accumulation of acetylated tr in nuclear fractions at 30-45 min and a decrease in signal by 60 min. a similar time course characterized r ... | 2005 | 15862828 |
| effect of dietary carbohydrate on haematology, respiratory burst activity and histological changes in l. rohita juveniles. | a feeding trial was conducted for 60 days to delineate the effect of dietary carbohydrate on the haematology, respiratory burst activity and histology in labeo rohita juveniles. one hundred and forty four fish (av. wt. 10+/-0.15 g) were randomly distributed into 12 treatment groups with each of two replicates. twelve semi-purified diets with either 35% or 28% of crude protein were prepared with different amylase concentrations (0, 50, 100 and 150 mgkg(-1)) and starch type (gelatinised, g/non-gel ... | 2005 | 15863014 |
| influence of spine morphology on intervertebral disc loads and stresses in asymptomatic adults: implications for the ideal spine. | sagittal profiles of the spine have been hypothesized to influence spinal coupling and loads on spinal tissues. | 2005 | 15863086 |
| can pathological complete response in the primary tumour following pre-operative pelvic chemoradiotherapy for t3-t4 rectal cancer predict for sterilisation of pelvic lymph nodes, a low risk of local recurrence and the appropriateness of local excision? | local excision is considered inappropriate treatment for t3-t4 rectal adenocarcinomas, as it cannot provide prognostic information regarding lymph node involvement and has a high risk of pelvic recurrence. preoperative chemoradiation (crt) studies in rectal cancer suggest that a pathological complete response (pcr) in the primary tumour provides an excellent long-term outcome. if downstaging to stage pt0 predicts a tumour response within the perirectal and pelvic lymph nodes, this may allow loca ... | 2006 | 15864605 |
| total mesorectal excision: the heidelberg results after tme. | the introduction of the total mesorectal excision (tme) has changed the treatment of rectal cancer dramatically by reducing the local recurrence rate. we report the results of 208 patients undergoing a low anterior resection (lar, n = 180) or abdominoperineal resection (apr, n = 28) with tme between 1 october 2001 and 30 september 2003. no adjuvant therapy was administered to any patient; however, 108 patients received neoadjuvant radiotherapy or radiochemotherapy. since february 2002, 51 patien ... | 2005 | 15865026 |
| efficacy of hepatocellular carcinoma locoregional therapies on patients waiting for liver transplantation. | the aim of this study was to evaluate the efficacy of different locoregional therapies in patients with hcc on the waiting list for liver transplantation. from october 2001 to july 2003, 13 patients, all men, with hcc diagnosed by cytology, were transplanted at our center. locoregional therapies were percutaneous ethanol injection (pei), transcatheter hepatic arterial chemoembolization (tace), and radiofrequency microwave ablation (rfa). pei was employed in seven patients, tace in five (one of t ... | 2005 | 15866648 |
| long-term survival of a patient with advanced adenosquamous carcinoma of the gallbladder after radical resection. | patients with adenosquamous carcinoma of the gallbladder tend to present with a bulky tumor that frequently displays involvement with adjacent organs, and diagnosis is usually made at an advanced stage. this may contribute to the poor prognosis of patients with adenosquamous carcinoma of the gallbladder compared to patients with adenocarcinoma. we present herein a patient with advanced adenosquamous carcinoma of the gallbladder who is doing well with no evidence of recurrence more than 5 years a ... | 2005 | 15868080 |
| neoadjuvant therapy for rectal cancer: improved tumor response, local recurrence, and overall survival in nonanemic patients. | preoperative, long-course chemoradiotherapy is recommended for rectal cancers involving or threatening the mesorectal resection margin, but tumor response is variable. some highly radiosensitive cancers completely regress, leading to reduced local recurrence and improved survival. this study was designed to evaluate the influence of anemia during chemoradiotherapy on tumor response, local and distant recurrence, and overall survival. | 2005 | 15868236 |
| good colorectal cancer surgery. | adenocarcinoma of the colon and rectum is currently diagnosed in about 783,000 new cases annually and 437,000 patients will die of the disease each year worldwide. colorectal cancer presents as an emergency situation (obstruction, bleeding or perforation) in approximately 25% of cases and with more or less obvious chronic symptoms in the rest of cases. rectal cancer patients, with a t1 tumour can be offered local excision whereas patients with more advanced cancer must be offered a more radical ... | 2005 | 15868491 |
| [effects of fentanyl on cytokines and mda during cardiopulmonary bypass in patients undergoing valve replacement]. | to investigate the effect of fentanyl on cytokines and mda in valve replacement surgery during cardiopulmonary bypass ( cpb). | 2005 | 15871195 |
| delayed recovery of vecuronium neuromuscular block in diabetic patients during sevoflurane anesthesia. | to study recovery from vecuronium-induced neuromuscular block in diabetic patients during total iv or sevoflurane anesthesia. | 2005 | 15872123 |
| risedronate decreases fracture risk in patients selected solely on the basis of prior vertebral fracture. | the aim of this study was to examine the effects of risedronate (5 mg/daily) in patients identified solely on the basis of a prior fragility fracture, without bmd as an inclusion criterion. a total of 1,802 patients were examined from the vert-na and vert-mn clinical trials. lateral radiographs (t4 to l4) were obtained at baseline and annually; incident fractures were evaluated using quantitative and semiquantitative methods at the central facility. bmd was measured at the lumbar spine and femor ... | 2004 | 15875093 |
| evaluation of photolyase (photosome) repair activity in human keratinocytes after a single dose of ultraviolet b irradiation using the comet assay. | photosome is constituted of photolyases included in liposomes. photolyase is a bacterial enzyme that can repair ultraviolet b (uvb)-induced cyclobutane pyrimidine dimers (cpd) in eukaryotic cells. a modified version of the alkaline comet assay has been set up to evaluate the repair activity of this enzyme after a single dose of uvb (312 nm, 0.06 j/cm2) in human keratinocytes. the formation of single strand breaks (ssb) induced by the uva photoactivation of the enzyme (1.2 j/cm2) was inhibited by ... | 2005 | 15878115 |
| structural and functional similarities between the capsid proteins of bacteriophages t4 and hk97 point to a common ancestry. | gene product (gp) 24 of bacteriophage t4 forms the pentameric vertices of the capsid. using x-ray crystallography, we found the principal domain of gp24 to have a polypeptide fold similar to that of the hk97 phage capsid protein plus an additional insertion domain. fitting gp24 monomers into a cryo-em density map of the mature t4 capsid suggests that the insertion domain interacts with a neighboring subunit, effecting a stabilization analogous to the covalent crosslinking in the hk97 capsid. seq ... | 2005 | 15878991 |
| renal cell carcinoma with renal vein and inferior vena caval involvement: clinicopathological features, surgical techniques and outcomes. | we present a contemporary review of patients with renal cell carcinoma (rcc) in whom renal vein/inferior vena caval thrombus was treated with radical nephrectomy and thrombectomy. | 2005 | 15879771 |
| treatment results of 1070 patients with nasopharyngeal carcinoma: an analysis of survival and failure patterns. | the aim of this analysis was to evaluate the outcomes of patients with nasopharyngeal carcinoma (npc) treated primarily by external beam irradiation (ert) and to explore for possible ways to improve the treatment results. | 2005 | 15880410 |
| psychological adjustment of parents of pediatric cancer patients revisited: five years later. | we investigated the psychological functioning of parents of children suffering from pediatric cancer using a prospective design over a five-year time period. parents of children diagnosed with cancer participated at diagnosis (t1), six months (t2), twelve months (t3), and five years later (t4, n = 115). repeated measures anovas were calculated for the three measures of psychological distress (ghq, scl-90 and stai-s) to examine changes over time and gender differences. independent t-tests were co ... | 2006 | 15880477 |
| an altered-specificity dna-binding mutant of escherichia coli sigma70 facilitates the analysis of sigma70 function in vivo. | the sigma subunit of bacterial rna polymerase is strictly required for promoter recognition. the primary (housekeeping) sigma factor of escherichia coli, sigma(70), is responsible for most of the gene expression in exponentially growing cells. the fact that sigma(70) is an essential protein has complicated efforts to genetically dissect the functions of sigma(70). to facilitate the analysis of sigma(70) function in vivo, we isolated an altered-specificity dna-binding mutant of sigma(70), sigma(7 ... | 2005 | 15882415 |
| transition from nonspecific to specific dna interactions along the substrate-recognition pathway of dam methyltransferase. | dna methyltransferases methylate target bases within specific nucleotide sequences. three structures are described for bacteriophage t4 dna-adenine methyltransferase (t4dam) in ternary complexes with partially and fully specific dna and a methyl-donor analog. we also report the effects of substitutions in the related escherichia coli dna methyltransferase (ecodam), altering residues corresponding to those involved in specific interaction with the canonical gatc target sequence in t4dam. we have ... | 2005 | 15882618 |
| correlation between histologic findings and cytogenetic abnormalities in bladder carcinoma: a fish study. | to investigate the chromosomal abnormalities present in bladder carcinoma using a fluorescence in situ hybridization assay and to correlate the genetic findings with the pathologic grade and stage. | 2005 | 15882723 |
| endocrine response of the freshwater teleost, sarotherodon mossambicus (peters) to dimecron exposure. | the endocrine response in a freshwater teleost, sarotherodon mossambicus (peters) under dimecron (an organophosphate pesticide) toxicity was investigated by estimating the serum levels of t3 (triiodothyronine), t4 (thyroxine), cortisol, prolactin and insulin in control and sub-lethal (0.001 ml l(-1)) dimecron-exposed fish for 1, 6, 12, 24h and 5 days. in control s. mossambicus, the serum levels of t3 ranged from 0.80+/-0.01 to 0.82+/-0.01 ng ml(-1); t4 from 2.20+/-0.01 to 2.25+/-0.01 microg dl(- ... | 2005 | 15882891 |
| [malignant paranasal sinus tumors. diagnosis, therapy and results]. | malignant neoplasmas of the paranasal sinuses are rare and present usually in advanced tumor stage due to the lack of early clinical symptoms. | 2005 | 15883842 |
| bacterial sensitivity to bacteriophage in the aquatic environment. | there are several unusual features about phage when you first encounter them as a biologist. they are small, but conform to one of a few morphological types. next their genomes can be composed of dna or rna and be single or double stranded. finally they are numerically more abundant than prokaryotes and a significant proportion of them form an association in their microbial host populations termed lysogeny. the latter findings indicate that they are numerically significant in microbial populatio ... | 2004 | 15884658 |
| phosphorylated extracellular signal-regulated kinase 1/2 immunoreactivity identifies a novel subpopulation of sympathetic preganglionic neurons. | distinct chemical codes are thought to reflect functional specificity in sympathetic preganglionic neurons (spn). although a number of chemical candidates have been identified including neurotransmitter-related, calcium-binding and other proteins, signal transduction proteins have been largely neglected. not only might these chemicals allow discrimination of functionally unique chemical signatures, but they may also identify activated neurons. immunoreactivity (ir) to phosphorylated extracellula ... | 2005 | 15885917 |
| serum 3,3',5'-triiodothyronine (rt3) and 3,5,3'-triiodothyronine/rt3 are prognostic markers in critically ill patients and are associated with postmortem tissue deiodinase activities. | critical illness is associated with reduced tsh and thyroid hormone secretion, and with changes in peripheral thyroid hormone metabolism, resulting in low serum t3 and high rt3. in 451 critically ill patients who received intensive care for more than 5 d, serum thyroid parameters were determined on d 1, 5, 15, and last day (ld). all patients had been randomized for intensive or conventional insulin treatment. seventy-one patients died, and postmortem liver and skeletal muscle biopsies were obtai ... | 2005 | 15886232 |
| transient hypothyroxinemia in preterm infants: the role of cord sera thyroid hormone levels adjusted for prenatal and intrapartum factors. | transient hypothyroxinemia is common in infants less than 30 wk gestation and is associated with neurodevelopmental deficits; it has no consensus definition. we previously suggested that appropriate ranges for postnatal serum t4 values are at least cord levels corrected to an equivalent gestational age if the fetuses had remained in utero. | 2005 | 15886240 |
| toxicity of a phytosterol mixture to grayling (thymallus thymallus) during early developmental stages. | the study concerns the toxicity of a phytosterol mixture, ultrasitosterol, consisting mainly of beta-sitosterol 75.7% and beta-sitostanol 13.0%, to grayling (thymallus thymallus) embryos. eyed eggs were exposed to three concentrations (1 microg/l, 10 microg/l, and 50 microg/l) of ultrasitosterol for 4 weeks. embryos and later on hatched fry were taken for triiodothyronine (t3), thyroxine (t4), and histopathological analyses after 7, 14, 21, and 28 days of exposure. most of the eggs (>95%) hatche ... | 2005 | 15886854 |
| [thyroidectomy associated with laryngectomy in laryngeal cancer treatment. is it routinely necessary?]. | in patients with laryngeal invasive epidermoid carcinoma who are candidates for total laryngectomy, it is recommended to resect en bloc at least half of the thyroid gland on the same side as the laryngeal tumor with the objective of decreasing local recurrence associated with thyroid infiltration. nevertheless, in the histopathologic analysis of the specimen, a minority of thyroid glands show tumor infiltration. the fact that in these patients even partial thyroid resection is associated with hy ... | 2005 | 15888262 |
| tumour angiogenesis and mast cell density in the prognostic assessment of colorectal carcinomas. | tumour angiogenesis is essential for the growth, invasion and metastasis of solid tumours. there are several lines of evidence that the mast cells play an important role in tumour angiogenesis. | 2004 | 15888280 |
| salt dependent binding of t4 gene 32 protein to single and double-stranded dna: single molecule force spectroscopy measurements. | bacteriophage t4 gene 32 protein (gp32) is a well-studied representative of the large family of single-stranded dna (ssdna) binding proteins, which are essential for dna replication, recombination and repair. surprisingly, gp32 has not previously been observed to melt natural dsdna. at the same time, *i, a truncated version of gp32 lacking its c-terminal domain (ctd), was shown to decrease the melting temperature of natural dna by about 50 deg. c. this profound difference in the duplex destabili ... | 2005 | 15890198 |
| comparison of effects of methylprednisolone and anti-cd11d antibody treatments on autonomic dysreflexia after spinal cord injury. | autonomic dysreflexia is a condition of episodic hypertension that develops after spinal cord injury (sci). we previously showed that a two-day anti-inflammatory treatment with an anti-cd11d integrin monoclonal antibody (mab), soon after sci in rats, reduced the magnitude of dysreflexia for at least 6 weeks. effects of methylprednisolone (mp), a commonly used neuroprotective treatment for sci, on dysreflexia have never been examined. we compared the effects of a 2-day mp treatment and/or the ant ... | 2005 | 15890340 |
| l-thyroxine activates akt signaling in the heart. | hyperthyroidism causes physiological cardiac hypertrophy and enhanced function. many of these effects have been traditionally attributed to changes in gene expression. however, the role of signal transduction pathways in the effects mediated by thyroid hormone (th) have recently gained a significant amount of attention in non-cardiovascular cells and tissue. whether signal transduction pathways are involved in the cardiac effects of th is unknown. in this study, we treated sprague dawley rats wi ... | 2005 | 15890358 |
| thyroid hormone availability and activity in avian species: a review. | the intracellular thyroid hormone (th) availability is influenced by different metabolic pathways. some of the changes in intracellular th availability can be linked to changes in local deiodination and sulfation capacities. the secretion of the chicken thyroid consists predominantly of thyroxine (t4). th receptors (trs) preferentially bind 3,5,3'-triiodothyronine (t3). therefore, the metabolism of t4 secreted by the thyroid gland in peripheral tissues, resulting in the production and degradatio ... | 2005 | 15890488 |
| the activities of antioxidant enzymes and monoamine oxidase and uncoupling protein 1 content in brown fat of hypo- and hyperthyroid rats. | we have studied the activities of antioxidant enzymes (aoe), namely, copper-zinc superoxide dismutase (cuznsod), manganese superoxide dismutase (mnsod), and catalase (cat), and the activity of catecholamine-degrading enzyme monoamine oxidase (mao) and uncoupling protein 1 (ucp1) content in brown fat (bf) of hypo- and hyperthyroid rats. we found that hypothyroidism decreased bf ucp1 content and increased mao, mnsod, and cat activities. t3 increased ucp1 content and mnsod activity and decreased cu ... | 2005 | 15891081 |
| evolution of the thyroid hormone distributor protein transthyretin in microbes, c. elegans, and vertebrates. | transthyretin (ttr) is an extracellular thyroid hormone distributor protein in vertebrates, whose structure has been highly conserved between fish and humans. however, the ligand preferentially bound by ttr has changed during evolution from 3',3,5-l-triiodothyronine (t3) to 3',5',3,5-l-tetraiodothyronine (t4). we identified genes in the genomes of >50 species of nonvertebrates, which could code for ttr-like proteins. molecular modeling suggested most would have similar 3d structures and electros ... | 2005 | 15891085 |
| effects of acute organophosphate poisoning on thyroid hormones in rats. | the aim of this study was to investigate the effects of organophosphate poisoning on thyroid hormones. in this study, male wistar albino rats weighing 200-225 g were used. the rats were divided into 4 groups. group 1 (n = 10) was administered 30 mg/kg lethal dose of methamidophos, whereas group 2 (n = 7) was treated with physiologic nacl (sp). group 3 (n = 10) was treated with 30 mg/kg of methamidophos. when cholinergic symptoms developed among the rats in group 3, they were treated with 40 mg/k ... | 2005 | 15891268 |
| [subacute meningoradiculomyeloencephalitis due to cryptococcosis infection]. | if meningoencephalitis with or without mass lesion (granuloma or abscess) is the most common pattern of cns cryptococcal infection, intramedullary involvement is very uncommon. | 2005 | 15893031 |
| comparison of neoadjuvant cisplatin-based chemotherapy versus radiochemotherapy followed by resection for stage iii (n2) nsclc. | comparison of prospectively treated patients with neoadjuvant cisplatin-based chemotherapy vs radiochemotherapy followed by resection for mediastinoscopically proven stage iii n2 non-small cell lung cancer with respect to postoperative morbidity, pathological nodal downstaging, overall and disease-free survival, and site of recurrence. | 2005 | 15896624 |
| prognostic significance of microvascularization in cases of operated lung cancer. | measurement of microvascularization and determination of its prognostic significance in cases of lung cancer. | 2005 | 15896626 |
| the oligomeric t4 primase is the functional form during replication. | replisome dna primases are responsible for the synthesis of short rna primers required for the initiation of repetitive okazaki fragment synthesis on the lagging strand during dna replication. in bacteriophage t4, the primase (gp61) interacts with the helicase (gp41) to form the primosome complex, an interaction that greatly stimulates the priming activity of gp61. because gp41 is hexameric, a question arises as to whether gp61 also forms a hexameric structure during replication. several results ... | 2005 | 15897200 |
| critical appraisal of the clinical and pathologic predictors of survival after resection of large hepatocellular carcinoma. | a subset of patients with hepatocellular carcinoma (hcc) with a diameter of 10 cm or larger may benefit from hepatic resection. | 2005 | 15897440 |
| the effect of low-flow sevoflurane and desflurane on pulmonary mechanics during laparoscopic surgery. | this study was designed to investigate the effects of inhaled anesthetic agents on respiratory mechanics with low flow anesthesia in laparoscopic abdominal surgery. two inhaled anesthetics, desflurane and sevoflurane, have a lower solubility in blood and tissues than all previous volatile anesthetics, and have become the preferred volatile anesthetics for routine surgical procedures. | 2005 | 15898901 |
| diagnosis of the depth of invasion of esophageal carcinoma using digital radiography. | the purpose of our investigation was to determine the usefulness of digital radiography (dr) for diagnosing the depth of invasion of esophageal carcinoma. | 2005 | 15899339 |
| clinical and immunohistologic typing of salivary duct carcinoma: a report of 50 cases. | due to the low incidence of salivary duct carcinoma (sdc), only limited data in regard to the biologic behavior of this tumor and its immunohistochemical characteristics are available. the authors analyzed the clinical, molecular, and genetic profile of sdc and identified prognostic factors. | 2005 | 15900577 |
| tumour staging using magnetic resonance imaging in clinically localised prostate cancer: relationship to biochemical outcome after neo-adjuvant androgen deprivation and radical radiotherapy. | to evaluate the prognostic significance of magnetic resonance imaging (mri) tumour stage in clinically localised prostate cancer. | 2005 | 15901000 |
| nad+-dependent dna ligase (rv3014c) from mycobacterium tuberculosis. crystal structure of the adenylation domain and identification of novel inhibitors. | dna ligases utilize either atp or nad+ as cofactors to catalyze the formation of phosphodiester bonds in nicked dna. those utilizing nad+ are attractive drug targets because of the unique cofactor requirement for ligase activity. we report here the crystal structure of the adenylation domain of the mycobacterium tuberculosis nad+-dependent ligase with bound amp. the adenosine nucleoside moiety of amp adopts a syn-conformation. the structure also captures a new spatial disposition between the two ... | 2005 | 15901723 |
| altered thyroxin and retinoid metabolic response to 2,3,7,8-tetrachlorodibenzo-p-dioxin in aryl hydrocarbon receptor-null mice. | to determine whether the disruption of thyroid hormone and retinoid homeostasis that occurs after exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (tcdd) can be mediated by the arylhydrocarbon receptor (ahr), pregnant ahr-heterozygous (ahr+/-) mice were administered a single oral dose of 10 microg kg(-1) tcdd at gestation day 12.5. serum and liver were collected on postnatal day 21 from vehicle-treated control or tcdd-treated ahr+/- and ahr-null (ahr-/-) mouse pups. whereas tcdd exposure resulted ... | 2004 | 15902423 |
| primary tumour volume: important predictor of outcome for t3- and t4-staged nasopharyngeal carcinoma. | to investigate the relationship between primary tumour volumes and treatment outcomes within t3- and t4-staged nasopharyngeal carcinoma. | 2004 | 15903207 |
| cluster formation by allelomimesis in real-world complex adaptive systems. | animal and human clusters are complex adaptive systems and many organize in cluster sizes s that obey the frequency distribution d (s) proportional to s(-tau). the exponent tau describes the relative abundance of the cluster sizes in a given system. data analyses reveal that real-world clusters exhibit a broad spectrum of tau values, 0.7 (tuna fish schools) <or=tau<or=4.61 (t4 bacteriophage gene family sizes). allelomimesis is proposed as an underlying mechanism for adaptation that explains the ... | 2005 | 15903699 |
| promising results of a cooperative group phase ii trial of preoperative chemoradiation for locally advanced rectal cancer (trog 9801). | this article reports the overall survival, failure-free survival, local failure, and late radiation toxicity of a phase ii trial of preoperative radiotherapy with continuous infusion 5-fluorouracil for rectal cancer after a minimum 3.5 years of follow-up. | 2005 | 15906126 |
| prospective non-randomized trial comparing esophagectomy-followed-by-chemoradiotherapy versus chemoradiotherapy-followed-by-esophagectomy for t4 esophageal cancers. | multimodal treatment is commonly adopted for patients with a t4 esophageal cancer. this trial evaluated which therapy offered a better survival: preoperative chemoradiotherapy (crt) or postoperative crt. | 2005 | 15906363 |
| an event-related potentials study on selective attention modulated by vestibular stimulation. | to explore the dynamic change of the late attentional selection process under linearly varied vestibular stimuli using event-related potentials (erps) technique. | 2004 | 15906485 |