| can selective retroperitoneal lymphadenectomy be better than unilateral retroperitoneal lymphadenectomy? | to propose a new modality of retroperitoneal lymphadenectomy as a complementary treatment for patients with high risk, stage i nonseminomatous testicular tumor. | 2003 | 15745585 |
| development of procedures for direct extraction of cryptosporidium dna from water concentrates and for relief of pcr inhibitors. | extraction of high-quality dna is a key step in pcr detection of cryptosporidium and other pathogens in environmental samples. currently, cryptosporidium oocysts in water samples have to be purified from water concentrates before dna is extracted. this study compared the effectiveness of six dna extraction methods (dna extraction with the qiaamp dna minikit after oocyst purification with immunomagnetic separation and direct dna extraction methods using the fastdna spin kit for soil, qiaamp dna s ... | 2005 | 15746310 |
| recombinant human tsh modulates in vivo c-telopeptides of type-1 collagen and bone alkaline phosphatase, but not osteoprotegerin production in postmenopausal women monitored for differentiated thyroid carcinoma. | in women monitored for thyroid carcinoma, short-term stimulation with rhtsh induced an acute decrease in serum c-telopeptides of type-1 collagen and an increase in serum balp levels without any effect on opg production. the inhibitory effect of tsh on bone resorption occurred only in postmenopausal women who showed low bmd and a high bone turnover rate as an effect of l-thyroxine suppressive therapy. | 2004 | 15746993 |
| how accurate is magnetic resonance imaging in restaging rectal cancer in patients receiving preoperative combined chemoradiotherapy? | preoperative combined chemoradiotherapy is currently the main neoadjuvant therapy used to treat locally advanced middle and low rectal adenocarcinoma. a restaging work-up with magnetic resonance imaging was hoped to provide information about the effects related to combined chemoradiotherapy. the goal was to evaluate the correlation between pathologically verified tumor stages and clinical stages predicted by magnetic resonance imaging after combined chemoradiotherapy. | 2005 | 15747073 |
| [effect of nickel sulfate on the concentrations of t3, t4 and tsh in serum of rat]. | the effect of nickel sulfate on the concentrations of t3, t4 and tsh in sera of rats was studied. forty wistar male rats were divided into four groups. the rats in groups 1, 2 and 3 were injected with 0.005 mol/l niso4, 0.01 mol/l niso4 and 0.02 mol/l niso4 [1 ml/(kg x d)] respectively, while the rats of group 4 were injected with normal saline, serving as control. forty days later, the concentrations of t3 and t4 in sera of 0.01 mol/l niso4 and 0.02 mol/l niso4 groups were obviously decreased ( ... | 1997 | 15747463 |
| physiological stress response to video-game playing: the contribution of built-in music. | recent studies on video game playing have uncovered a wide range of measurable physiological effects on the organism, such as increases in cardiovascular activity and breathing responses. however, the exact source of these effects remains unclear. given the well-known effects of sound on physiological activity, especially those of noise and of music, and on the secretion of the stress hormone cortisol in particular, we hypothesized that music may be a major source of stress during video game pla ... | 2005 | 15748630 |
| production of symmetrical flatfish by controlling the timing of thyroid hormone treatment in spotted halibut verasper variegatus. | the thyroid hormone plays an essential role in the metamorphosis in flatfish, during which external asymmetry (for example, eye relocation and pigmentation) is established. however, no information is available on the expression mechanisms of metamorphic asymmetry. since the presence of malformed juveniles (having either ocular or blind side characteristics on both sides) was known in spotted halibut (verasper variegatus), the effect of the timing of thyroid hormone treatment was investigated. wh ... | 2005 | 15748720 |
| iodothyronine deiodinases and the control of plasma and tissue thyroid hormone levels in hyperthyroid tilapia (oreochromis niloticus). | thyroid status is one of the most potent regulators of peripheral thyroid hormone metabolism in vertebrates. despite this, the few papers that have been published concerning the role of thyroid hormones in the regulation of thyroid function in fish often offer conflicting data. we therefore set out to investigate the effects of tetraiodothyronine (thyroxine) (t4) or tri-iodothyronine (t3) supplementation (48 p.p.m.) via the food on plasma and tissue thyroid hormone levels as well as iodothyronin ... | 2005 | 15749806 |
| iodine overload and severe hypothyroidism in a premature neonate. | use of iodinated skin disinfectants in the perinatal period can result in significant iodine overload of the neonate and transient hypothyroidism. the authors report a case of unusually severe hypothyroidism requiring l-thyroxine (l-t4) replacement therapy in a premature neonate after prolonged use of iodinated skin disinfectants for a complex skin lesion. neonatal iodine overload should be minimized, and in cases with significant iodine exposure, thyroid-stimulating hormone should be monitored, ... | 2005 | 15750908 |
| the intraoperative effect of pentoxifylline on the inflammatory process and leukocytes in cardiac surgery patients undergoing cardiopulmonary bypass. | inflammation plays a pivotal role in the pathogenesis of organ dysfunction after cardiopulmonary bypass (cpb). the aim of this study was to investigate whether pentoxifylline (ptx) has effects on the inflammatory process and leukocytes in cardiac surgery patients undergoing cpb. | 2005 | 15751670 |
| united arab emirates national newborn screening programme: an evaluation 1998-2000. | to evaluate the united arab emirate national newborn screening programme we compared coverage, timeliness of programme indicators (age at sampling, recall and treatment initiation, timing of specimen delivery and laboratory results) and specimen quality with international standards. recall rate, sensitivity, specificity, positive predictive values and relative incidence rates for phenylketonuria (pku) and congenital hypothyroidism (ch) were calculated. investigations for hypothyroidism included ... | 2003 | 15751925 |
| what pretreatment prostate-specific antigen level warrants long-term androgen deprivation? | several large randomized prospective studies have demonstrated a survival benefit with the addition of long-term androgen deprivation to definitive radiotherapy for patients with gleason score 8-10 or t3-t4 prostate cancer. however, these studies were performed before the routine use of prostate-specific antigen (psa) measurement. the purpose of this study was to determine what pretreatment (initial) psa (ipsa) level, if any, warrants the addition of long-term androgen deprivation in the psa era ... | 2005 | 15752879 |
| pretreatment anemia is correlated with the reduced effectiveness of radiation and concurrent chemotherapy in advanced head and neck cancer. | pretreatment anemia is an adverse prognostic variable in squamous cell head-and-neck cancer (hnc) patients treated with radiotherapy (rt) alone. tumor hypoxia is an adverse parameter for treatment with rt alone or with rt and concurrent chemotherapy (cct). tumor hypoxia is more prevalent in patients who present with pretreatment hemoglobin (hgb) concentrations less than 13 g/dl. rt/cct improves survival over rt alone in advanced hnc, and its use is becoming more widespread. this study was perfor ... | 2005 | 15752888 |
| human recombinant tsh preceding a therapeutic dose of radioiodine for multinodular goiters has no significant effect in the surge of tsh-receptor and tpo antibodies. | radioiodine (rai) treatment has increasingly been used mostly in elderly patients with multinodular goiter (mng) as an alternative for surgery. recombinant human thyrotropin (rhtsh) has been demonstrated to increase the uptake of rai and also to promote a more even distribution of radionuclide among the various nodules. we have compared the surge of autoantibodies to thyroid peroxidase (anti-tpo) and to the tsh receptor (trab) in two groups of patients with mng. group rai (n = 15) received only ... | 2005 | 15753672 |
| expression of cyclooxygenase-2 in colorectal cancer and its clinical significance. | to clarify the clinicopathologic significance of cox-2 expression in human colorectal cancer. | 2005 | 15754389 |
| age as a predictor of recurrent hypothyroidism in patients with post-partum thyroid dysfunction. | the long term effect of post-partum thyroid dysfunction (pptd) is not well established. this study was conducted to evaluate the outcome of permanent hypothyroidism and factors predictive of thyroid dysfunction in a large cohort of women with pptd. in 164 women, treated with levothyroxine for moderate and severe post- partum hypothyroidism, the treatment was discontinued and subjects were followed-up for the recurrence of hypothyroidism. factors such as thyroid function tests, tyroid peroxidase ... | 2004 | 15754729 |
| [prognosis of epidermoid anal carcinoma regression after conservative treatment]. | the prospective study was concerned with definition of the clinical and therapeutic factors behind poor response of anal cancer to radio- (rt) or chemoradiotherapy (crt). out of 64 female and 8 male patients at the mean age of 57 (33-81), thirty six had split-course of 60-65 gy (rt), twenty--60-65 gy, 5-fu and mitomycin c (crt) and eighteen--up to 55-65 gy (1.5 gy--session 1, 1.0 gy--session 2) (hyper-fractionated rt) plus 5-fu, for squamous cell anal carcinoma. there was no endorectal ultrasoun ... | 2004 | 15755059 |
| hypothyroidism in rats decreases peripheral glucose utilisation, a defect partially corrected by central leptin infusion. | the aims of this work were to determine the effect of hypothyroidism on insulin-stimulated glucose turnover and to unravel the potential mechanisms involved in such an effect. | 2005 | 15756538 |
| [radical surgery of the malignant laryngeal tumors]. | modern therapeutical protocols for treatment of t3 and t4 malignomas of the larynx are not adjusted, because there are attempts to treat these diseases with non-operative methods (such as chemo- and radiotherapy) in order to preserve the organ. the aim of the study was to establish today's results of the surgical treatement of patients with t3 and t4 laryngeal malignoma. we studied the group of patients with laryngeal carcinoma, who had undergone total laryngectomy, during the period of eight ye ... | 2004 | 15756784 |
| [clinical analysis of resectable breast cancer: a report of 6 263 cases]. | in europe and america, breast cancer commonly occurs in women of middle and old age, the median age of patients is about 57 years old. modified radical mastectomy has taken the place of traditional radical mastectomy, and is called standard radical mastectomy. patients with breast cancer of early stage commonly receive breast conservative therapy. tnm stage (especially the lymph node status) affects the prognosis, and adjuvant therapy can improve the survival. in china, just a few clinical resea ... | 2005 | 15757535 |
| increased levels of serum osteoprotegerin in hypothyroid patients and its normalization with restoration of normal thyroid function. | hypothyroidism is associated with increased morbidity from cardiovascular disease, and an increase in serum osteoprotegerin (opg) has recently been reported to be associated with the severity of coronary heart disease and cardiovascular mortality. the present study was designed to examine whether hypothyroidism causes an increase in serum opg, and to determine whether levothyroxine (l-t4) replacement therapy might suppress serum opg levels in hypothyroid patients. fifty-three hypothyroid patient ... | 2005 | 15757850 |
| rapid differential diagnosis of graves' disease and painless thyroiditis using total t3/t4 ratio, tsh, and total alkaline phosphatase activity. | when thyrotoxic patients are first seen in an outpatient clinic, it is important to make a differential diagnosis of graves' disease (gd) and painless thyroiditis (pt). using the three parameters of total t3/t4 ratio, tsh and t-alp activity, all of which can be obtained within one hour in our hospital, 173 untreated patients with thyrotoxicosis were evaluated for the ratio of each parameter. for gd vs. pt, total t3/t4 (ng/microg) ratio (>20), tsh (<0.005 microu/ml) and elevated t-alp had a likel ... | 2005 | 15758555 |
| lymph node micrometastasis in stage ii distal rectal cancer following neoadjuvant chemoradiation therapy. | the objective was to determine the presence and frequency of micrometastasis in lymph nodes of patients with rectal cancer treated by preoperative chemoradiation followed by curative resection. | 2005 | 15759124 |
| [thyroid diseases in reproductive-age women living in shoria mountains]. | to analyze prevalence and structure of thyroid pathology in women of reproductive age living in shoria mountains. | 2005 | 15759450 |
| measuring energy expenditure using heart rate to assess the effects of wheelchair tyre pressure. | to investigate the effects of wheelchair tyre pressure on mechanics and energy and explore the use of heart rate as a measurement of energy expenditure. | 2005 | 15759533 |
| [longitudinal study of pituitary-thyroid axis in pregnancy]. | the thyroid undergoes important changes during pregnancy. in order to evaluate changes of the hypophyseal-thyroid axis during this period we studied the thyroid function in 587 pregnants by determining serum tsh, free t4, tpo antibodies and betahcg in the 1st trimester and serum tsh, free t4 and tpoab in to 2nd and 3rd. we observed a progressive rise in average serum tsh in the 2nd (2.14 mu/l) and 3rd (2.96 mu/l) trimesters when compared to the 1st (1.39 mu/l). serum tsh values in the 1st trimes ... | 2004 | 15761512 |
| [effect of the hypothyroidism-castration association on bone and parathyroids from adult female rats]. | the effect of hypothyroidism on bone metabolism and the parathyroids in states of deficiency or sufficiency of sex steroids was studied in 32 two-months-old female wistar rats distributed in 4 groups of 8 animals each: intact euthyroid (ie), castrated euthyroid (ce), intact hypothyroid (ih) and castrated hypothyroid (ch). after 120 days of treatment, animals were sacrificed and plasma taken to assess free t4. hyperplasia or hypertrophy of all parathyroids were evident only in ih and ce groups. o ... | 2004 | 15761517 |
| [bone effects of the association hyperthyroidism-castration of adult female rats]. | the relationship between thyroid, gonads and bone morphology was investigated in 5 month-old wistar rats, castrated and kept in hyperthyroid or euthyroid state for periods of 30, 60 and 90 days. a non-castrated control group was maintained in the same condition. at the end of each period, plasma concentrations of free t4, progesterone and estradiol were measured. the bones from each group were submitted to radiological and histological analysis. hyperthyroidism in intact rats caused variation in ... | 2004 | 15761563 |
| [thyrotoxic hypocalemic periodic paralysis: report of 3 cases]. | thyrotoxic hypokalemic periodic paralysis (thpp) is a rare hyperthyroidism complication much more frequent in asians and caucasians. we present 3 cases of thpp occurring in brazilian male patients with 28 years old (y) (case 1), 29 y (case 2) and 60 y (case 3), respectively. they were admitted following an episode of flacid paralysis of extremities. whereas case 1 reported recurring episodes of paralysis crises, cases 2 and 3 reported only one episode. signs and symptoms of thyrotoxicosis, such ... | 2004 | 15761566 |
| the effect of l-thyroxine replacement therapy on lipid based cardiovascular risk in subclinical hypothyroidism. | the aim of our study was to assess the changes in serum lipid profiles after replacement therapy with l-t4 in patients with subclinical hypothyroidism (sch), and to see whether there is an improvement in dyslipidemia based cardiovascular risk. thirty non-smoker pre-menopausal women with newly diagnosed sch (tsh between 4 and 10 microiu/ml) were involved in our study; twenty-six euthyroid healthy subjects were used as control group. tsh, free t3 (ft3), free t4 (ft4), total cholesterol (tc), trigl ... | 2004 | 15762035 |
| i-131 therapy for thyroglobulin positive patients without anatomical evidence of persistent disease. | the aim of this retrospective study was to evaluate the diagnostic relevance of i-131 whole body scan (wbs) performed after second empirical therapeutic doses of iodine-131 (i-131) in thyroglobulin (tg)-positive thyroid cancer patients without evidence of local and distant metastasis. we also evaluated the efficacy of second empirical therapeutic doses of i-131 in these patients. | 2004 | 15762043 |
| subclinical hyperthyroidism: clinical features and treatment options. | subclinical hyperthyroidism appears to be a common disorder. it may be caused by exogenous or endogenous factors: excessive tsh suppressive therapy with l-thyroxine (l-t4) for benign thyroid nodular disease, differentiated thyroid cancer, or hormone over-replacement in patients with hypothyroidism are the most frequent causes. consistent evidence indicates that 'subclinical' hyperthyroidism reduces the quality of life, affecting both the psycho and somatic components of well-being, and produces ... | 2005 | 15762182 |
| which role for radiation therapy in ethmoid cancer? a retrospective analysis of 84 cases from a single institution. | to define the results of radiotherapy for the treatment of ethmoid carcinoma in a large, retrospective, substantially unselected series from a single institution. | 2004 | 15762359 |
| 5'-nucleotidase activity is altered by hypo- and hyperthyroidism in platelets from adult rats. | thyroid disorders are associated to a number of vascular diseases that involve processes such as platelet aggregation and vascular tone control. since, these processes can be also affected by atp, adp and adenosine levels, we investigate the hydrolysis of these nucleotides in platelets from hyperthyroid, hypothyroid, and hypothyroid with hormonal replacement rats. hyperthyroidism was induced by daily injections of l-thyroxine (t4) 25 microg/100 g body weight for 14 days. hypothyroidism was induc ... | 2005 | 15763893 |
| follow-up of differentiated thyroid carcinoma. | thyroid cancer is the most common endocrine malignancy. more than 90% of primary thyroid cancers are differentiated papillary or follicular types. the treatment of differentiated thyroid carcinoma (dtc) consists of total thyroidectomy and radioactive iodine ablation therapy, followed by l-thyroxine therapy. the extent of initial surgery, the indication for radioiodine ablation therapy and the degree of tsh-suppression are all issues that are still being debated cancers are in relation to the ris ... | 2004 | 15765026 |
| [clinical review of mucoepidermoid carcinomas]. | mucoepidermoid carcinoma is a rare head and neck cancer tumor, composed of both mucous and epidermoid cells. we retrospectively reviewed the case of 36 such patients hospitalized in the last 24 years (between 1978 and 2002) at kurume university hospital, focusing on origin, treatment, and treatment outcome. in this study, 33 patients undergoing currative treatment were studied in detail. tumors originated in major salivary glands in 24 and in the oral cavity, paranasal cavity, and oropharynx in ... | 2005 | 15765727 |
| [efficacy of treatment of benign thyroid nodules by percutaneous ethanol injection]. | the aim of the study was to evaluate the long-term efficacy and safety of percutaneous ethanol injection (pei) to solitary benign thyroid nodules in 232 patients (213 women and 19 men) in whom other treatments were refused or contraindicated. patients were divided into two groups. group i was comprised of 155 women and 17 men in state of euthyreosis, with cystic or solid nodules. group ii was comprised of 58 women and 2 men with pretoxic adenoma (tsh < 0.1 microiu/ml, t3 and t4 within normal lim ... | 2004 | 15765752 |
| physiological and morphological correlates of among-individual variation in standard metabolic rate in the leopard frog rana pipiens. | rates of standard metabolism (smr) are highly variable among individuals within vertebrate populations. because smr contributes a substantial proportion of an individual's energy budget, among-individual variation in this trait may affect other energetic processes, and potentially fitness. here, we examine three potential proximate correlates of variation in smr: organ mass, serum t4 thyroxine and relative mitochondrial content, using flow cytometry. body-mass-adjusted kidney mass correlated wit ... | 2005 | 15767318 |
| ethmoid sinus cancer: results of treatment with surgery and combined therapy. | ethmoid sinus cancer is a rare paranasal sinus malignancy. its characteristics include a low incidence rate, a great variety of histopathological types and multiple treatment modalities. currently, there remains no definite consensus regarding its optimal management. the aim of this study was to examine the outcome of a population of asian patients with advanced ethmoid sinus cancers that had been treated with surgery plus combined therapy. | 2004 | 15768822 |
| [t4 tracheo-bronchial carcinoma: clinical evaluation of 48 sleeve pneumonectomies]. | the aim of the study was to verify the indications for surgery in t4 tracheo-bronchial carcinomas. forty-eight tracheal-sleeve pneumonectomies for t4 bronchogenic carcinoma were performed in our unit from 1986 to 2003. the patients were 42 males and 6 females. a postero-lateral thoracotomy was preferred (46 right, 2 left). bronchial reimplantation was performed additionally (tracheal-sleeve lobectomy) in 2 patients on the right side. the morbidity was 25% and the mortality 6.2% (1 acute respirat ... | 2004 | 15771031 |
| parallel biomolecular computation on surfaces with advanced finite automata. | a biomolecular, programmable 3-symbol-3-state finite automaton is reported. this automaton computes autonomously with all of its components, including hardware, software, input, and output being biomolecules mixed together in solution. the hardware consisted of two enzymes: an endonuclease, bbvi, and t4 dna ligase. the software (transition rules represented by transition molecules) and the input were double-stranded (ds) dna oligomers. computation was carried out by autonomous processing of the ... | 2005 | 15771530 |
| a novel 1297-1304delgcctgcca mutation in the exon 10 of the thyroid hormone receptor beta gene causes resistance to thyroid hormone. | resistance to the thyroid hormone (rth) is an inherited syndrome of reduced tissue responsiveness to hormonal action caused by mutations located in the ligand-binding domain and adjacent hinge region of the thyroid hormone receptor beta (trbeta) gene. | 2004 | 15771554 |
| [long-term results of different treatment modalities in 464 hypopharyngeal squamous-cell carcinoma patients]. | to present the treatment results and to identify the most effective therapeutic plan of different therapeutic modalities in patients with squamous-cell carcinoma of hypopharynnx. | 2005 | 15771800 |
| prediction of poor survival by cyclooxygenase-2 in patients with t4 nasopharyngeal cancer treated by radiation therapy: clinical and in vitro studies. | this study was undertaken to determine the status of cyclooxygenase-2 (cox-2) in nasopharyngeal cancer (npc) in taiwanese patients and its relationship to survival after radiotherapy (rt). in addition, the effect of ns-398, a potent selective cox-2 inhibitor, was tested in vitro alone and in combination with radiation on npc-bm1 human npc cells as a prelude to using this drug along with rt in the treatment of patients with npc. | 2005 | 15772955 |
| [dysthyroidism after 60 years of age]. | this work has been conducted on 162 subjects, aged over 60 years, living in senegal, investigated in the departement of biophysics and nuclear medecine of dakar for suspicion of dysthyroidism. the levels of t3, t4 and tsh us hormones were determined by a radio-immunological method. this technique, exhibiting good functionnal sensitivity and its high specificity, is likely to be beneficial to the diagnosis of dysthyroidisms. besides, this experiment leads us to consider that the dosage of tsh rem ... | 2001 | 15773172 |
| [endothelin et-1 in patients with non-toxic nodular goiter]. | endothelin et-1 plays an important, however not entirely identified role in physiology and pathology of thyroid gland. the aim of the study was to determine if in patients with non-toxic nodular goiter there is relationship between size of goiter and et-1 concentration in plasma of peripheral venous blood and plasma of venous blood taken from thyroid vein in patients undergoing strumectomy. the study included 30 patients with non-toxic nodular goiter (29 women and 1 man, mean age 48 year) and 15 ... | 2004 | 15773428 |
| endoscopic ultrasound for esophageal and gastroesophageal junction cancer: impact of increased use of primary neoadjuvant therapy on preoperative locoregional staging accuracy. | initial treatment of locally advanced esophageal and gastroesophageal junction (gej) malignancies for selected patients at some institutions has recently changed from surgical resection to neoadjuvant therapy. the aim of this study is to evaluate the impact of this change in treatment strategy on both the overall disease profile and locoregional endoscopic ultrasound (eus) staging accuracy for a cohort of patients managed with primary surgical resection over a 10-year period at our institution. ... | 2005 | 15773837 |
| [correlation between prevalent and incident osteoporotic vertebral fractures in beijing male elderly]. | to investigate the correlation between prevalent and incident osteoporotic vertebral fractures in beijing male elderly. | 2005 | 15774211 |
| [spinal anaesthesia for cesarean section: rate and management of complications in 110 senegalese parturients]. | the goal of this prospective work is to study the per- and post-operative complications of spinal anaesthesia for cesarean and to evaluate their management. we included in the study all parturients undergoing cesarean section to the maternity of hospital aristide le dantec since december 1998 to march 1999. patients presented contra-indications of spinal anaesthesia, arterial hypertension and/or acute fetal distress were excluded. after a vascular preload of 1000 ml of ringer lactate, a spinal a ... | 2002 | 15776685 |
| epidural ropivacaine 1% with and without sufentanil addition for caesarean section. | so far only ropivacaine concentrations of 0.5 and 0.75% have been used for caesarean section. this prospective double-blind trial evaluated the anaesthetic quality of ropivacaine 1% with and without sufentanil addition. | 2005 | 15777301 |
| efficacy of sufentanil addition to ropivacaine epidural anaesthesia for caesarean section. | this prospective double-blind trial evaluated the effect of sufentanil addition to epidural ropivacaine for elective caesarean section. | 2005 | 15777302 |
| [mrna expression of igf-iiand hgf in relation to microvascular density, tumor progression and prognosis of gastric carcinoma]. | to investigate whether correlation exists between mrna expression of igf-ii and hepatocyte growth factor (hgf) and tumor progression and prognosis in gastric cancer. | 2004 | 15777506 |
| mechanism of dna binding and localized strand separation by pur alpha and comparison with pur family member, pur beta. | pur alpha is a single-stranded (ss) dna- and rna-binding protein with three conserved signature repeats that have a specific affinity for guanosine-rich motifs. pur alpha unwinds a double-stranded oligonucleotide containing purine-rich repeats by maintaining contact with the purine-rich strand and displacing the pyrimidine-rich strand. mutational analysis indicates that arginine and aromatic residues in the repeat region of pur alpha are essential for both ss- and duplex dna binding. pur alpha b ... | 2005 | 15777841 |
| determination of the orientation of t4 lysozyme vectorially bound to a planar-supported lipid bilayer using site-directed spin labeling. | site-directed spin labeling is used to investigate the structure of adsorbed t4 lysozyme (t4l). a monolayer of t4l is prepared by tethering the protein selectively via a his-tag to the chelating headgroups (nta ni) of a planar quartz-supported lipid bilayer. this results in a vectorially oriented ensemble of proteins on the surface, which gives rise to angular-dependent electron paramagnetic resonance spectra. similar measurements of spin-labeled lipid bilayers were used to characterize the stru ... | 2005 | 15778448 |
| effects of selective visual attention in the parietal and temporal areas of the human cortex using evoked potential data. | studies of 11 young subjects addressed the analysis of evoked potentials in the parietal and temporal areas to sequential presentation of visual symbols on the left and right sides; symbols were squares and circles and were observed passively and in conditions of selective attention to target stimuli presented to the subjects in random order and requiring rapid and precise motor responses. comparison of monopolar evoked potentials in leads p3, p4, t3, t4, t5, and t6 with bipolar potentials in le ... | 2005 | 15779328 |
| thyroid hormone status in gray seal (halichoerus grypus) pups from the baltic sea and the atlantic ocean in relation to organochlorine pollutants. | marine apex predators, such as the gray seal (halichoerus grypus), are exposed to high concentrations of organochlorine (oc) compounds via biomagnification in the food web. these lipophilic pollutants are transferred from the female to her offspring during lactation, and there is particular concern for endocrine disruption in the offspring. herein we examined associations between the blubber concentrations of polychlorinated biphenyls (pcbs), dichlorodiphenyltrichloroethane (ddt) and metabolites ... | 2005 | 15779761 |
| description and initial evaluation of a xenopus metamorphosis assay for detection of thyroid system-disrupting activities of environmental compounds. | a need is recognized for the development and evaluation of bioassays for detection of thyroid system-disrupting compounds. the issue of testing for thyroid disruption can be addressed by exploiting amphibian metamorphosis as a biological model. in the present study, a test protocol for a xenopus metamorphosis assay (xema) was developed and its interlaboratory transferability was evaluated in an informal ring test with six laboratories participating. in the xema test, exposure of xenopus laevis t ... | 2005 | 15779766 |
| effects of perchlorate exposure on resting metabolism, peak metabolism, and thyroid function in the prairie vole (microtus ochrogaster). | perchlorate, the oxidizer component in most solid rocket propellant formulations, is known to inhibit the uptake of iodide into the thyroid gland, thereby reducing production of the thyroid hormones, triiodothyronine and thyroxine (t4). thyroid hormones regulate metabolism in endothermic organisms and are responsible for maintenance of homeothermic body temperatures. little is known about the effects of perchlorate on metabolic capacity. the objectives of the present study were to determine if s ... | 2005 | 15779769 |
| variables associated with recurrence in breast cancer patients-the shaukat khanum memorial experience. | from a cohort of female breast cancer patients registered at the shaukat khanum memorial cancer hospital and research center, in lahore, pakistan, during the time period extending from december 1994 to december 2002, 700 subjects who were followed up in time, were selected. those who presented with benign tumors, carcinoma in situ, or metastases were excluded from the analyses. age, tumor size, nodal status, menopause, estrogen receptor (er), and progesterone receptor (pr) status, at the time of ... | 2005 | 15780033 |
| bacteriophage t4 helicase loader protein gp59 functions as gatekeeper in origin-dependent replication in vivo. | bacteriophage t4 initiates origin-dependent replication via an r-loop mechanism in vivo. during in vitro reactions, the phage-encoded gp59 stimulates loading of the replicative helicase, gp41, onto branched intermediates, including origin r-loops. however, although gp59 is essential for recombination-dependent replication from d-loops, it does not appear to be required for origin-dependent replication in vivo. in this study, we have analyzed the origin-replicative intermediates formed during inf ... | 2005 | 15781450 |
| case of prolonged alcohol withdrawal syndrome accompanied with hyperthyroidsim. | hyperthyroidism is associated with increased psychiatric morbidity. it may alter the clinical course of alcohol withdrawal syndrome. we report a 69 year old man who presented prolonged alcohol withdrawal syndrome associated with hyperthyroidism. initially, he developed typical alcohol withdrawal syndrome including tremor, disorientation, delirium and visual hallucination of small animals. thyroid function tests revealed a free triiodothyronine (t3) of 6.1 pg/dl (range, 3.0 to 5.8), a free thyrox ... | 2005 | 15782582 |
| total syntheses of amphidinolides t1 and t4 via catalytic, stereoselective, reductive macrocyclizations. | described in this work are total syntheses of amphidinolides t1 and t4 using two nickel-catalyzed reductive coupling reactions of alkynes, with an epoxide in one case (intermolecular) and with an aldehyde in another (intramolecular). the latter was used to effect a macrocyclization, form a c-c bond, and install a stereogenic center with >10:1 selectivity in both natural product syntheses. alternative approaches in which intermolecular alkyne-aldehyde reductive coupling reactions would serve to j ... | 2005 | 15783211 |
| different mitogen-mediated beta-adrenergic receptor modulation in murine t lymphocytes depending on the thyroid status. | the aim of this work was to analyze beta-adrenergic receptor (betaar) regulation of t-lymphocyte proliferation in mice according to different thyroid hormone statuses. | 2005 | 15785111 |
| intensified concurrent chemoradiotherapy with 5-fluorouracil and irinotecan as neoadjuvant treatment in patients with locally advanced rectal cancer. | this study aimed to evaluate the feasibility and efficacy of neoadjuvant chemoradiotherapy intensified with irinotecan in patients with locally advanced rectal cancer. eligible patients had nonmetastatic disease at a locally advanced stage that made r0 resection and sphincter preservation uncertain. they received preoperative radiation over 6 weeks to 45 gy and boost of 5.4 gy and concurrent continuous infusion 5-fluorouracil 250 mg m(-2) day(-1) and weekly irinotecan 40 mg m(-2). in all, 37 pat ... | 2005 | 15785742 |
| [non iatrogenic primary hypothyrodism in adults at le dantec hospital : clinical features, diagnosis and treatment. review of 19 cases]. | the authors report 19 cases of non iatrogenic primary hypothyroidism in adults at le dantec hospital of dakar. those cases had been found during a period of 6 years and half in the internal medicine service. the aim was to study clinical features, diagnosis and outcome of patients after treatment. the mean age of patients was 42.2 years with a sex-ratio of 0.33 m/f. the diagnosis delay was around 6,1 years. all patients presented clinical signs of hypometabolism: physical asthenia (63.15%), fril ... | 2004 | 15786618 |
| thyroid disorders in hemodialysis patients in an iodine-deficient community. | there are various changes in the thyroid gland and its function in chronic renal failure (crf). these changes include lower levels of circulating thyroid hormone, altered peripheral hormone metabolism, decreased binding to carrier proteins, possible reduction in tissue hormone content, and increased iodine storage in the thyroid gland. the decrease of excretion of urinary iodine in crf increases serum inorganic iodine level and iodine content of the thyroid, which consequently enlarges the gland ... | 2005 | 15787628 |
| is the relationship between adherence behaviours and glycaemic control bi-directional at adolescence? a longitudinal cohort study. | to analyse the change in adherence to diabetes treatment and its association with metabolic control from childhood to adolescence. the tanner pubertal staging model was selected as a marker of developmental maturity. | 2005 | 15787668 |
| [determination of amylose content in transgenic progenies containing an antisense waxy gene and identifying of pure lines in indica rice]. | through genetic transformation mediated by agrobacterium tumefaciens, an antisense waxy gene was introduced into longtefu b line, a male sterile maintainer line in indica (oryza sativa l.). thirty transgenic plants showed integration of antisense waxy gene into the genome as determined by pcr assay, and twenty eight were confirmed by southern blotting. t1 seeds from twenty one transgenic plants showed a marked decrease of amylose content, ranging from 3%-13% less than control, and seeds from som ... | 2004 | 15789760 |
| a comparison of the pathology of transitional cell carcinoma of the bladder and upper urinary tract. | to clarify the histopathological patterns of upper and lower urinary tract transitional cell carcinomas (tccs), as previous reports suggest that upper urinary tract tccs have a greater tendency towards high-grade disease than bladder tccs, of which most are low-grade and low-stage tumours. | 2005 | 15794784 |
| [effects of various iodin-nutritional on activity of t4 5'-and 5-deiodinase in rat brain]. | to investigate the changing of t4 5'-and 5-deiodinase within rat brain under various iodin-nutritional states. | 2005 | 15794888 |
| height, weight, igf-i, igfbp-3 and thyroid functions in prepubertal children with attention deficit hyperactivity disorder: effect of methylphenidate treatment. | to investigate if there are any disease-related or methylphenidate-induced aberrations in growth parameters, growth hormone insulin-like growth factor (igf)-i, igfbp-3 axis and the thyroid function tests in children with attention deficit hyperactivity disorder (adhd). | 2005 | 15795512 |
| do thyroxine and thyroid-stimulating hormone levels reflect urinary iodine concentrations? | the toxicity of environmental chemicals such as nitrates, thiocynates, and perchlorates, some therapeutics, and dietary goitrogens can lower thyroidal iodine uptake and result in hypothyroidism and goiter. iodine sufficiency, essential for normal thyroid hormone synthesis, is critical during gestation to assure that sufficient thyroxine (t4) and iodine reach the developing fetus. spot urinary iodide (ui) measurements are used globally to indicate and monitor iodine sufficiency of populations. in ... | 2005 | 15795649 |
| the surgical management of superior sulcus tumors: a retrospective review with long-term follow-up. | we reviewed our experience with multimodality therapy for superior sulcus tumors to identify aspects of treatment that impact survival. | 2005 | 15797046 |
| spinal cord compression due to vertebral osteochondroma: report of two cases. | osteochondroma, or exostosis, is the most common of all benign bone tumors. spinal osteochondromas are uncommon but may cause neurological compromise. we report two cases of spinal cord compression by osteochondromas. one patient was a 17-year-old man with hereditary multiple exostoses who was presented with spastic paraparesis, a sensory level at t3-t4, and a pyramidal syndrome. vertebral exostosis was suspected by magnetic resonance imaging and confirmed by histological examination. surgical d ... | 2005 | 15797501 |
| removal of mismatched bases from synthetic genes by enzymatic mismatch cleavage. | the success of long polynucleotide de novo synthesis is largely dependent on the quality and purity of the oligonucleotides used. generally, the primary product of any synthesis reaction is directly cloned, and clones with correct products have to be identified. in this study, a novel strategy has been established for removing undesired sequence variants from primary gene synthesis products. single base-pair mismatches, insertions and deletions were cleaved with specific endonucleases. three dif ... | 2005 | 15800209 |
| analysis of single nucleotide incorporation reactions by capillary electrophoresis. | single nucleotide incorporation assays have been used to probe the kinetic parameters of many dna and rna polymerases. traditionally, oligonucleotide primers are 5'-(32)p labeled using t4 kinase and annealed to a complementary template with a 5' overhang. to quantify the reaction kinetics, the products of the primer extension reactions are usually separated using denaturing polyacrylamide gel electrophoresis and quantified using a phosphorimager or other method to measure radioactivity. we have ... | 2005 | 15802127 |
| transcription regulation by bacteriophage t4 asia. | bacteriophage t4 asia, a strong inhibitor of bacterial rna polymerase, was the first antisigma protein to be discovered. recent advances that made it possible to purify large amounts of this highly toxic protein led to an increased understanding of asia function and structure. in this review, we discuss how the small 10-kda asia protein plays a key role in t4 development through its ability to both inhibit and activate bacterial rna polymerase transcription. | 2005 | 15802215 |
| the p5 protein from bacteriophage phi-6 is a distant homolog of lytic transglycosylases. | peptidases are classical objects of enzymology and structural studies. however, a few protein families with experimentally characterized proteolytic activity, but unknown catalytic mechanism and three-dimensional structures, still exist. using comparative sequence analysis, we deduce spatial structure for one of such families, namely, u40, which contains just one p5 protein from bacteriophage phi-6. we show that this singleton sequence possesses conserved sequence motifs characteristic of lysozy ... | 2005 | 15802648 |
| histological evaluation of biopsies obtained from vertebral compression fractures: unsuspected myeloma and osteomalacia. | a histological evaluation of biopsies obtained from presumed osteoporotic vertebral compression fractures (vcf) to confirm possible osteomalacia after tetracycline labeling. | 2005 | 15803081 |
| the treatment of advanced sinonasal malignancies with pre-operative intra-arterial cisplatin and concurrent radiation. | malignancies of the nasal and paranasal sinuses are uncommon tumors, accounting for only 3% of all aerodigestive tract neoplasms. despite advances in surgical techniques and continued evolution of adjuvant therapies, the 5-year mortality remains unusually high at greater than 50%. in 1996, we begin utilizing a novel strategy in the treatment of advanced sinonasal carcinomas. this consisted of neoadjuvant selective intra-arterial cisplatin with concurrent radiation therapy (acronym radplat) follo ... | 2005 | 15803378 |
| identification of a novel pulmonary oedema producing toxin from indian red scorpion (mesobuthus tamulus) venom. | the experiments were conducted to identify the toxin that produces pulmonary oedema in mesobuthus tamulus (bt) envenomed animals. crude bt venom was subjected to sephadex gel filtration (g-75) and the fractions were screened for optical density (od), neurotoxicity (prolongation of compound action potential in frog sciatic nerve) and lethality. all these parameters exhibited a peak between 54-94 ml eluates. fractions of this peak were pooled (sp) and loaded on to carboxymethyl cellulose column. t ... | 2005 | 15804522 |
| anterior vocal commissure invasion in laryngeal carcinoma diagnosis. | laryngeal carcinoma involving anterior vocal commissure (avc) represents a great challenge for staging and treatment. | 2005 | 15805888 |
| force field impact and spin-probe modeling in molecular dynamics simulations of spin-labeled t4 lysozyme. | several attempts have been made to compute electron paramagnetic resonance (epr) spectra of biomolecules, using motional models or simulated trajectories to describe dynamics. ideally, the simulated trajectories should capture "fast" (picosecond) snapshots of spin-probe rotations accurately, while being lengthy enough to ensure a proper fourier integration of the time-domain signal. it is the interplay of the two criteria that poses computational challenges to the method. in this context, an ana ... | 2005 | 15806387 |
| [construction and expression of recombinant plasmid with prostate-specific membrane antigen promoter and enhancer regulating uracil phosphoribosyltransferase gene]. | to construct the recombinant expression plasmid ppsma(ep)-uprt including uprt gene that is regulated by psma(enhancer/promoter). | 2005 | 15807258 |
| prevalence and progression of subclinical hypothyroidism in women with type 2 diabetes: the fremantle diabetes study. | to assess the prevalence and progression of subclinical hypothyroidism in women with type 2 diabetes. | 2005 | 15807880 |
| thyroid hormone receptor binding to dna and t3-dependent transcriptional activation are inhibited by uremic toxins. | background: there is a substantial clinical overlap between chronic renal failure (crf) and hypothyroidism, suggesting the presence of hypothyroidism in uremic patients. although crf patients have low t3 and t4 levels with normal thyroid-stimulating hormone (tsh), they show a higher prevalence of goiter and evidence for blunted tissue responsiveness to t3 action. however, there are no studies examining whether thyroid hormone receptors (trs) play a role in thyroid hormone dysfunction in crf pati ... | 2005 | 15807894 |
| a clinical and therapeutic approach to thyrotoxicosis with thyroid-stimulating hormone suppression only. | subclinical hyperthyroidism is defined as normal serum free thyroxine (t4) and triiodothyronine (t3) concentrations and persistently suppressed thyroid stimulating hormone (tsh) concentrations. the most common cause of subclinical hyperthyroidism is the use of suppressive doses of l-thyroxine for treatment of hypothyroidism or, less commonly, diffuse nontoxic goiter or thyroid carcinoma (exogenous subclinical hyperthyroidism). endogenous subclinical hyperthyroidism may be caused by a variety of ... | 2005 | 15808130 |
| cloning and characterization of the hsp70 multigene family from silver sea bream: modulated gene expression between warm and cold temperature acclimation. | the genes encoding heat shock cognate 70 (hsc70) and inducible heat shock protein 70 (hsp70) were cloned and characterized from silver sea bream liver. upon acute heat shock (+7 degrees c), the transcript abundance of hsc70 was increased 1.7-fold whereas the transcript abundance of hsp70 increased 6.7-fold. the chronic acclimation of sea bream to cold temperature (12 degrees c) resulted in a downregulation of hsc70 and an upregulation of hsp70 in comparison to levels in sea bream kept at a warme ... | 2005 | 15809064 |
| laparoscopic esophagectomy in the palliative treatment of advanced esophageal cancer after radiochemotherapy. | esophageal cancer is associated with a poor long-term prognosis. only a 10% 5-year survival rate is reported. this article aims to evaluate the feasibility and efficacy of laparoscopic esophagectomy for the palliative treatment of advanced esophageal cancer (t3-t4 nx-n1) after neoadjuvant therapy. | 2004 | 15809792 |
| ibandronate produces significant, similar antifracture efficacy in north american and european women: new clinical findings from bone. | bone (oral ibandronate osteoporosis vertebral fracture trial in north america and europe) determined whether less frequent dosing of ibandronate (dose-free interval > 2 months) provided similar antifracture efficacy to daily dosing. as osteoporosis medications must be effective across different populations, an additional objective of bone was to investigate and report the effect of oral ibandronate in north american and european women, as described here. | 2005 | 15811208 |
| hypo-and hyperthyroidism affect the atp, adp and amp hydrolysis in rat hippocampal and cortical slices. | the presence of severe neurological symptoms in thyroid diseases has highlighted the importance of thyroid hormones in the normal functioning of the mature brain. since, atp is an important excitatory neurotransmitter and adenosine acts as a neuromodulatory structure inhibiting neurotransmitters release in the central nervous system (cns), the ectonucleotidase cascade that hydrolyzes atp to adenosine, is also involved in the control of brain functions. thus, we investigated the influence of hype ... | 2005 | 15811553 |
| effects of ammonium perchlorate on thyroid function in developing fathead minnows, pimephales promelas. | perchlorate is a known environmental contaminant, largely due to widespread military use as a propellant. perchlorate acts pharmacologically as a competitive inhibitor of thyroidal iodide uptake in mammals, but the impacts of perchlorate contamination in aquatic ecosystems and, in particular, the effects on fish are unclear. our studies aimed to investigate the effects of concentrations of ammonium perchlorate that can occur in the environment (1, 10, and 100 mg/l) on the development of fathead ... | 2005 | 15811828 |
| overall survival after concurrent cisplatin-radiotherapy compared with radiotherapy alone in locoregionally advanced nasopharyngeal carcinoma. | this phase iii randomized study compared concurrent cisplatin-radiotherapy (crt) versus radiotherapy (rt) alone in patients with locoregionally advanced nasopharyngeal carcinoma. a total of 350 patients were randomly assigned to receive external rt alone or concurrently with cisplatin at a dosage of 40 mg/m(2) weekly. the primary endpoint was overall survival, and the median follow-up was 5.5 years. the 5-year overall survival was 58.6% (95% confidence interval [ci] = 50.9% to 66.2%) for the rt ... | 2005 | 15812080 |
| a novel homogenous assay for topoisomerase ii action and inhibition. | topoisomerase ii is the only enzyme able to cleave and religate double-stranded dna; this makes it essential for many vital functions during normal cell growth. increased expression of topoisomerase ii is a common occurrence in neoplasia, and different topoisomerase ii inhibitors have indeed been proven to be powerful anticancer drugs. for this reason, the topoisomerase ii catalytic cycle has attracted strong interest, but only a few techniques contributing to studies in this field have emerged. ... | 2005 | 15812853 |
| the antiproliferative agents trans-bis(resorcylaldoximato)copper(ii) and trans-bis(2,3,4-trihydroxybenzaldoximato)copper(ii) and cytopathic effects of hiv. | trans-bis(resorcylaldoximato)copper(ii) and trans-bis-(2,3,4-trihydroxybenzaldoximato)copper(ii) (cures2 and cutri2, respectively) have been tested for antiviral properties against hiv, using an in vitro assay that measures the ability of the test compounds to prevent the killing of susceptible human cells by hiv. in the case of cutri2, t4 lymphocytes (cem-v and cem-z cell lines) were exposed to hiv at a virus to cell ratio approx. 0.05 in microtiter plates. in the case of cures2, a human leukem ... | 2004 | 15813388 |
| identification and distribution of acanthamoeba species genotypes associated with nonkeratitis infections. | acanthamoeba is a free-living protozoan genus found in a wide variety of natural habitats, including water, soil, and air. pathogenic isolates of acanthamoeba are medically relevant as the causative agent of sight- threatening acanthamoeba keratitis (ak), serious infections of other organs, and fatal granulomatous amebic encephalitis. previous work employing dna sequences of nuclear and mitochondrial small-subunit rrna genes (ssu rrna genes) determined the genotypic diversity of acanthamoeba and ... | 2005 | 15814986 |
| reappraisal of the risk of iodine-induced hyperthyroidism: an epidemiological population survey. | the occurrence of iodine-induced hyperthyroidism (iih) has been reported after iodine supplementation from clinics and hospitals, but not following an epidemiologic survey. we studied the prevalence of thyroid derangement in a population following iodine supplementation. one yr after more than 75% of the population had been consuming 40 ppm iodized salt; information regarding history of endemic goiter and iodized salt production, distribution, consumption and monitoring were collected in four ci ... | 2005 | 15816367 |
| gabexate mesilate hastens recovery from vecuronium-induced neuromuscular blockade. | to test the hypothesis that gabexate mesilate, a protease inihibitor, hastens recovery from neuromuscular blockade, we examined the effect of gabexate mesilate on the recovery of vecuronium-induced neuromuscular blockade in anaesthetized patients in a double-blind, randomized fashion. | 2005 | 15816568 |
| color-doppler using contrast medium in evaluating the response to neoadjuvant treatment in patients with locally advanced breast carcinoma. | the aim of our study was to assess the color-doppler ultrasound (cdu) pattern in the analysis of neoadjuvant preoperative treatment of patients with locally advanced breast carcinoma, improvement after injection of contrast medium (levovist) and possible correlations between morphological and vascular aspects of the neoplasm and postoperative histopathological findings. | 2005 | 15816633 |
| brain stem mechanisms underlying acupuncture modality-related modulation of cardiovascular responses in rats. | the present study was designed to investigate brain stem responses to manual acupuncture (ma) and electroacupuncture (ea) at different frequencies at pericardial p (5-6) acupoints located over the median nerve. activity of premotor sympathetic cardiovascular neurons in the rostral ventral lateral medulla (rvlm) was recorded during stimulation of visceral and somatic afferents in ventilated anesthetized rats. we stimulated either the splanchnic nerve at 2 hz (0.1-0.4 ma, 0.5 ms) or the median ner ... | 2005 | 15817715 |