| comparison of late rectal toxicity from conventional versus three-dimensional conformal radiotherapy for prostate cancer: analysis of clinical and dosimetric factors. | to compare late rectal toxicity (lrt) after definitive radiotherapy (dr) and salvage radiotherapy (sr) in prostate cancer using conventional (conv) or three-dimensional conformal (3-d) techniques. | 2005 | 15667875 |
| growth of dalbergia sissoo in desert regions of western india using municipal effluent and the subsequent changes in soil and plant chemistry. | increasing demand for fodder and fuelwood and the scarcity of a good quality water in arid areas has resulted in a search for an alternative source of water for biomass production. an experiment utilizing municipal effluent in growing dalbergia sissoo was conducted. five treatments included t1, municipal effluent at 1 pet (potential evapo-transpiration) (without plant); t2, municipal effluent at 1/2 pet; t3, municipal effluent at 1pet; t4, municipal effluent at 2 pet; and t5, canal water at 1 pe ... | 2005 | 15668198 |
| myocardial ultrastructure in cardiac hypertrophy induced by thyroid hormone--an acute study in rats. | the early responses of the myocardium ultrastructure under thyroid dysfunction conditions, hemodynamic parameters, cardiac hypertrophy and ultrastructural evaluations were performed in hypothyroid and hyperthyroid rats submitted to different doses [t4-25 and t4-100; 0.025 mg and 0.1 mg kg(-1) body weight (bw).per day, respectively)]. all groups were treated for 7 days. the animals were sacrificed, the hearts were excised and weighed and the left ventricle tissue samples were processed for transm ... | 2005 | 15668802 |
| laryngeal cancer patients: analysis of patient delay at different tumor stages. | the aim of this study was to determine the length of stages (appraisal, illness, behavioral, and scheduling) of patient delay in patients with head and neck cancer and to find out whether these delays were related to the stage of the disease at diagnosis. | 2005 | 15668927 |
| is stimulation of thyroglobulin (tg) useful in low-risk patients with thyroid carcinoma and undetectable tg on thyroxin and negative neck ultrasound? | to determine the usefulness of thyroglobulin (tg) stimulation in low-risk patients with undetectable tg on t4 and negative neck ultrasound (us) after initial therapy of thyroid carcinoma. | 2005 | 15670185 |
| changes in thyroid hormone state in children receiving chemotherapy. | the concentrations of thyroid function determinants may change during severe illness. our goal was to quantify their changes in children with cancer during chemotherapy, and to correlate them to clinical condition and type of drugs. | 2005 | 15670204 |
| alternative input devices for efficient navigation of large ct angiography data sets. | to compare devices for the task of navigating through large computed tomographic (ct) data sets at a picture archiving and communication system workstation. | 2005 | 15670996 |
| colocalization of carbonic anhydrase 9 expression and cell proliferation in human head and neck squamous cell carcinoma. | tumor cells undergo a variety of biological changes under sustained hypoxic conditions, allowing cells to survive and retain their clonogenic potential. the purpose of this study is to relate the expression of the hypoxia marker carbonic anhydrase 9 (ca9) to the uptake of iododeoxyuridine (idurd), a marker of proliferation, in head and neck squamous cell carcinomas. colocalization of idurd and ca9 may identify an important subpopulation of tumor cells that might be responsible for repopulation a ... | 2005 | 15671533 |
| clinical usefulness of a long-term treatment with an antithyroid drug for psoriasis vulgaris. | we have previously reported that an antithyroid thiourethylene, thiamazole, can bring about significant clinical improvement in patients with psoriasis vulgaris. although the efficacy of antithyroid thiourethylenes had been reported earlier, few studies have evaluated the safety of its long-term use. in this study, we aimed to study whether or not long-term thiamazole administration is complicated by any adverse effects. eight patients with psoriasis vulgaris were enrolled in this study after in ... | 2004 | 15672705 |
| increased hepatobiliary clearance of unconjugated thyroxine determines dmp 904-induced alterations in thyroid hormone homeostasis in rats. | 4-(3-pentylamino)-2,7-dimethyl-8-(2-methyl-4-methoxyphenyl)-pyrazolo-[1,5-a]-pyrimidine (dmp 904) is a potent and selective antagonist of corticotropin releasing factor receptor-1 (crf1 receptor) with an efficacious anxiolytic profile in preclinical animal models. in subchronic toxicity studies in sprague-dawley rats, dmp 904 produced thyroid follicular cell hypertrophy and hyperplasia, and a low incidence of follicular cell adenoma. the current investigations were designed to determine the mode ... | 2005 | 15673846 |
| spinal 2-chloroprocaine: the effect of added clonidine. | preservative-free 2-chloroprocaine (2-cp) is being investigated for short-acting spinal anesthesia. clonidine improves the quality of spinal bupivacaine and ropivacaine, but in traditional doses (1-2 microg/kg) it produces systemic side effects. it has not been studied in combination with 2-cp. in this double-blind, randomized crossover study, we compared spinal 2-cp (30 mg) with and without clonidine (15 microg) in eight volunteers. pinprick anesthesia, motor strength, tolerance to electrical s ... | 2005 | 15673894 |
| spinal 2-chloroprocaine: a comparison with small-dose bupivacaine in volunteers. | ambulatory surgery continues to increase nationwide. because spinal lidocaine is associated with transient neurologic symptoms, many clinicians have switched to small-dose bupivacaine for outpatient spinal anesthesia. however, bupivacaine often produces inadequate surgical anesthesia and has an unpredictable duration. preservative-free 2-chloroprocaine (2-cp) has reemerged as an alternative for outpatient spinal anesthesia. we designed this double-blind, randomized, crossover, volunteer study to ... | 2005 | 15673895 |
| spinal 2-chloroprocaine: a comparison with procaine in volunteers. | recent studies using preservative-free 2-chloroprocaine (2-cp) for spinal anesthesia have shown it to be a reliable short-acting drug that provides similar anesthesia to lidocaine. in this randomized, double-blind, crossover study, we compared the characteristics of spinal 2-cp (30 mg) with those of procaine (80 mg) in eight volunteers to determine whether either drug produces spinal anesthetic characteristics ideal for outpatient surgery. by using sensation to pinprick, transcutaneous electrica ... | 2005 | 15673896 |
| massage treatment in hiv-1 infected dominican children: a preliminary report on the efficacy of massage therapy to preserve the immune system in children without antiretroviral medication. | more than 1.4 million children are living with hiv and global access to antiretrovirals is not yet readily available. massage therapy, which has been shown to improve immune function in hiv+ adults and adolescents, may provide an important complementary treatment to boost immune status in young children living with hiv disease, especially those without access to antiretroviral medications. no studies have been conducted, however, that specifically target massage therapy to enhance immune functio ... | 2004 | 15674006 |
| does substitution of t4 with t3 plus t4 for t4 replacement improve depressive symptoms in patients with hypothyroidism? | substitution of t4 with t3 for t4 replacement in patients with hypothyroidism was undertaken using a randomized placebo controlled study design. forty individuals were included who had depressive symptoms on stable doses of levothyroxine. combined t4 plus t3 did not have a significantly different effect on mood and well-being scores than did t4 alone. | 2004 | 15677430 |
| a novel endoribonuclease, rnase ls, in escherichia coli. | the dmd gene of bacteriophage t4 is required for the stability of late-gene mrnas. when this gene is mutated, late genes are globally silenced because of rapid degradation of their mrnas. our previous work suggested that a novel escherichia coli endonuclease, rnase ls, is responsible for the rapid degradation of mrnas. in this study, we demonstrated that rnla (formerly yfjn) is essential for rnase ls activity both in vivo and in vitro. in addition, we investigated a role of rnase ls in the rna m ... | 2005 | 15677746 |
| [serotypes, genotypes and drug resistance of group a streptococcal strains isolated in 1991, 2001 and 2002 in tokushima prefecture--comparison after decade]. | sixty two strains of group a streptococcus were isolated between august 2001 and june 2002. they were examined for t serotypes, pyrogenic exotoxin genes and resistance against antibiotics. the results were compared with those for 61 isolates of the same species collected between april and december 1991. among the strains isolated in 1991, t4 was the dominant serotype (18 strains) followed by t12 and t1 (each 15 strains). these three serotypes represented 78.7% of the total number. in contrast, a ... | 2004 | 15678976 |
| [larynx preservation: nonsurgical approaches]. | the question of larynx preservation is central in the management of patients with a carcinoma of the larynx or hypopharynx, especially to preserve the main functions of the larynx. in early stages (t1-earlyt2) larynx preservation can generally be obtained with partial surgery or radiotherapy. some other approaches such as exclusive chemotherapy require further investigations. in locally advanced and infiltrating larynx/hypopharynx carcinomas, (advancedt2-t3), several ways have been used to prese ... | 2004 | 15679243 |
| relative importance of secondary structure and solvent accessibility to the stability of protein mutants. a case study with amino acid properties and energetics on t4 and human lysozymes. | understanding the factors influencing the stability of protein mutants is an important task in molecular and computational biology. in this work, we have approached this problem by examining the relative importance of secondary structure and solvent accessibility of the mutant residue for understanding/predicting the stability of protein mutants. we have used hydrophobic, electrostatic and hydrogen bond free energy terms and nine unique physicochemical, energetic and conformational properties of ... | 2005 | 15680583 |
| phase iii study of matrix metalloproteinase inhibitor prinomastat in non-small-cell lung cancer. | matrix metalloproteinases (mmps) degrade extracellular proteins and facilitate tumor growth, invasion, metastasis, and angiogenesis. this trial was undertaken to determine the effect of prinomastat, an inhibitor of selected mmps, on the survival of patients with advanced non-small-cell lung cancer (nsclc), when given in combination with gemcitabine-cisplatin chemotherapy. | 2005 | 15681529 |
| ontogeny of pituitary thyrotrophs and regulation by endogenous thyroid hormone feedback in the chick embryo. | increased thyroid hormone production is essential for hatching of the chick and for the increased metabolism necessary for posthatch endothermic life. however, little is known about the ontogeny and distribution of pituitary thyrotrophs during this period or whether pituitary thyroid-stimulating hormone (tsh) production is regulated by endogenous thyroid hormones during chick embryonic development. this study assessed the abundance and location of pituitary thyrotrophs and the regulation of tsh( ... | 2005 | 15684348 |
| laparoscopic radical prostatectomy after neoadjuvant hormonal therapy: an apparently safe and effective procedure. | in an effort to determine the safety and efficacy of laparoscopic radical prostatectomy (lrp) in patients who have received neoadjuvant hormonal therapy (nht), our initial series of 65 patients undergoing successful lrp was analyzed, specifically comparing 5 patients who received neoadjuvant hormonal therapy to 60 who did not. | 2004 | 15684777 |
| combined-modality therapy of rectal cancer with irinotecan-based regimens. | there are two conventional treatments for clinically resectable rectal cancer. the first is surgery followed by postoperative combined-modality therapy if the tumor is t3 and/or n1/2. the second, if the tumor is ultrasound t3 or clinical t4, is preoperative combined-modality therapy followed by surgery and postoperative chemotherapy. there are a number of new chemotherapeutic agents that have been developed for the treatment of colorectal cancer. phase i/ii trials are examining the use of new ch ... | 2004 | 15685836 |
| irreversible and reversible adhesion between virus particles and hydrolyzing-precipitating aluminium: a function of coagulation. | the infectivity of viruses (qbeta, ms2, t4, and p1) after dosing virus-contaminated water with 4 types of aluminium coagulant was investigated. the concentrations of infectious viruses were determined after dissolving aluminium hydroxide flocs in alkaline solution. the concentration of infectious viruses did not recover to the initial value after a short floc-dissolution time (5 s). although the infectious virus concentration increased as the floc-dissolution time was extended to 5 h, it did not ... | 2004 | 15686022 |
| [preliminary results of thyroid function assessment in children and adolescents with hodgkin's disease (hd) treated according to pgp-hd-97 protocol]. | the intensive treatment of hd (multidrug chemotherapy combined with radiotherapy) carries the risk of early and late complications. one of the late effects is thyroid dysfunction which may occur after radiotherapy of the cervical region. in this report preliminary results of thyroid function assessment in children with hd in correlation with time after cessation of therapy are presented. between january 1, 1997 and december 31, 2002, 58 children with hd (age: 2.6-18.3 years, median, 14.9 years) ... | 2004 | 15686053 |
| repeated exercise stress testing identifies early and late preconditioning. | the warm-up phenomenon has been considered to trigger preconditioning. we investigated whether repeated exercise treadmill tests in humans are capable of inducing adaptation to ischemia by triggering both the early and late phase of preconditioning. | 2005 | 15686771 |
| hypothyroxinemia in mechanically ventilated term infants is associated with increased use of rescue therapies. | although common in preterm infants, transient hypothyroxinemia (th) has not been investigated extensively in ill term infants. the objectives of this study were to investigate serum thyroxine (t4) and thyroid-stimulating hormone (tsh) in sick term infants and to determine whether there is any association between measures of thyroid function and short-term outcome in term infants who receive mechanical ventilation. | 2005 | 15687450 |
| electrophysiologic characteristics of atrial myocytes in levo-thyroxine-treated rats. | to investigate whether thyroid hormone modulates electrical properties of atrial myocytes, electrocardiogram (ecg), action potentials (aps), and ionic currents were measured. male sprague-dawley rats were randomly divided into control and levo-thyroxine (t4)-treated groups at 6 weeks of age. levo-thyroxine (500 microg/kg of body weight) was injected daily into the peritoneal cavity for 14 days (t4-treated rats) and the same volume of saline was injected in control rats daily. ecg signals were re ... | 2005 | 15687814 |
| underestimates and overestimates of total thyroxine concentrations caused by unwanted thyroxine-binding protein effects. | the first evidence of unwanted serum protein effects on analogue-based total thyroxine (t4) determinations came from a study that varied serum protein concentrations while total t4 concentrations were constant. the present study approached this issue by varying total t4 concentrations while protein concentrations were constant. four analogue-based total t4 immunoassays were applied to solutions that contained either free t4 without binding protein, a t4-binding protein without t4, or protein-bou ... | 2005 | 15687815 |
| a case of idiopathic spinal cord herniation with duplicated dura mater. | the patient was a 48-year-old man in whom a slow progression in walking difficulty occurred over a year. magnetic resonance imaging (mri) and computed tomography myelography (ctm) revealed duplicated dura mater from t1 to t12 and spinal cord herniation in the inner layer of the dura at the t4-t5 level. idiopathic spinal cord herniation with duplicated dura mater was diagnosed, and surgery was performed. intraoperative findings were of an elliptical defect of about 1 cm in the inner layer of the ... | 2005 | 15687862 |
| [131 iodine for the treatment of benign goiters]. | in order to evaluate the efficacy of 131 iodine on goitre volume and on thyroid function, we studied a cohort of patients exhibiting a multinodular and toxic or non toxic goitre. | 2005 | 15687976 |
| castleman's disease with diffuse cervical localisation: case report. | castleman's disease is a rare disorder of the lymphoid tissue with a predominantly mediastinic localisation, but possible in any lymph node or extra-lymph node site. the aetiopathogenesis remains to be defined and, in the literature, only just over 500 cases have been reported, with only 57 located in a cervical site. clinically, a solitary or localised form and a systemic or multicentric form can be distinguished, whilst, from a histological viewpoint, this lesion may be of the hyaline vascular ... | 2004 | 15688910 |
| the outcome of radical surgery and postoperative radiotherapy for squamous carcinoma of the temporal bone. | the objective was to analyze the clinical data and outcome of all the patients treated surgically for squamous carcinoma of the temporal bone in a tertiary referral department of skull base surgery over a 20-year period. | 2005 | 15689763 |
| morphometric x-ray absorptiometry: reference data for vertebral dimensions in a population-based sample of young danish men. | to determine reference values for vertebral heights in healthy young danish males using morphometric x-ray absorptiometry (mxa). | 2004 | 15690617 |
| fingerprinting of single viral genomes. | we demonstrate the use of technology developed for optical mapping to acquire dna fingerprints from single genomes for the purpose of discrimination and identification of bacteria and viruses. single genome fingerprinting (sgf) provides not only the size but also the order of the restriction fragments, which adds another dimension to the information that can be used for discrimination. analysis of single organisms may eliminate the need to culture cells and thereby significantly reduce analysis ... | 2005 | 15691508 |
| incidence of chest wall paresthesia after needlescopic video-assisted thoracic surgery for palmar hyperhidrosis. | chest wall paresthesia is a reported sequela of thoracotomy and video-assisted thoracic surgery (vats) which is distinct from wound pain. although needlescopic vats confers less post-operative pain and better cosmesis, the incidence of paresthesia after needlescopic vats has not been quantified. | 2005 | 15691688 |
| insulin increases the adrenergic stimulation of 5' deiodinase activity and mrna expression in rat brown adipocytes; role of mapk and pi3k. | type ii 5' deiodinase (d2) activity produces triiodothyronine (t3) from thyroxine (t4) and is induced by cold and norepinephrine (ne) in brown adipose tissue. t3 is required for and amplifies the adrenergic stimulation of d2 activity and mrna in cultured brown adipocytes. d2 is upregulated by insulin and decrease in fasting. we now study the regulation by insulin of the adrenergically induced d2 activity and mrna in primary cultures of rat brown adipocytes. insulin alone does not increase d2 act ... | 2005 | 15691884 |
| evaluation of mechanisms inducing thyroid toxicity and the ability of the enhanced oecd test guideline 407 to detect these changes. | the oecd has developed an "enhanced test guideline 407" (tg 407) protocol for detecting endocrine effects during the course of a 28-day testing scheme. this protocol has gone through a validation process with (anti)estrogenic and (anti)androgenic compounds and substances that affect the thyroid (thyroxine and propylthiouracil). this review investigates whether a 28-day testing scheme would show up alterations in the thyroid-related parameters of the "enhanced tg 407" (t3, t4, tsh, thyroid weight ... | 2005 | 15692820 |
| micropapillary carcinoma of the urothelial tract. a clinicopathologic study of 38 cases. | micropapillary carcinoma (mpc) of the bladder is a rare and aggressive variant of bladder carcinoma. the goals of this study are to investigate whether this variant of bladder carcinoma represents a more aggressive disease than conventional urothelial carcinoma (cuc) and to determine the incidence of mpc in our country. a total of 630 urothelial carcinomas diagnosed from 1997 to 2003 at the department of pathology, oncology hospital, in mexico city were analyzed to identify mpc. thirty-eight pat ... | 2005 | 15692943 |
| [mood disorders, psychopharmacology and thyroid hormones]. | for more than 40 years thyroid hormones and mood disorders have been associated. some psychiatric symptoms are produced by thyroid illnesses and there is a frequent association of thyroid dysfunction with mood disorders. therefore, routine thyroid function assessment in patients with mood disorders and the treatment of sub-clinical thyroid dysfunctions is recommended. the usefulness of adding thyroid hormones to antidepressive treatment in euthyroid patients to obtain a potentiation effect has b ... | 2004 | 15693206 |
| preoperative radiochemotherapy and radical resection for stages ii-iv oral and oropharyngeal cancer: outcome of 222 patients. | to analyse survival and locoregional control in patients with advanced oral and oropharyngeal squamous cell carcinoma (scc) after multimodal therapy with preoperative radiochemotherapy (rct) and radical surgery. we included in this analysis 222 patients who underwent multimodal therapy between 1990 and 2000. eligible were patients with uicc disease stages ii-iv (t2: 33.3%; t3: 12.6%; t4: 54.1%; n0: 45.9%; n1: 17.6%; n2: 33.3%; n3: 3.2%; stage ii: 21.1%; stage iii: 14.9%; stage iv: 64%). patients ... | 2005 | 15695042 |
| prognostic relevance of cd105+ microvessel density in hnscc patient outcome. | angiogenesis is essential for the development and progression of malignant tumours, and there is increasing evidence that microvessel density (mvd) can be considered an indirect marker of neo-angiogenesis. however, there is still disagreement concerning the clinical relevance and prognostic significance of mvd in head and neck squamous cell carcinomas (hnsccs). mvd was evaluated in 127 hnscc patients by means of immunohistochemistry using monoclonal antibodies (mabs) against cd34 and cd105 (endo ... | 2005 | 15695116 |
| [a family with familial dysalbuminaemic hyperthyroxinaemia]. | to report a family of familial dysalbuminaemic hyperthyroxinaemia(fdh). | 2005 | 15696477 |
| middle-age male mice have increased severity of experimental autoimmune encephalomyelitis and are unresponsive to testosterone therapy. | treatment with sex hormones is known to protect against experimental autoimmune encephalomyelitis (eae), an animal model of multiple sclerosis. however, little is known about how age affects the course of eae or response to hormone treatment. this study demonstrates striking differences between middle-age vs young c57bl/6 male mice in the clinical course of eae and response to both testosterone (t4) and estrogen (e2) hormone therapy. unlike young males that developed an acute phase of eae follow ... | 2005 | 15699175 |
| effects of hypothyroidism on gonadal function after transition of short day photoperiod in male golden hamsters (mesocricetus auratus). | thyroid hormones permit the annual reproductive transition of seasonal breeders. although, precise function of thyroid hormones in seasonal breeding is not well understood. in the present study, we examined effects of hypothyroidism on the hypothalamus-pituitary-gonadal axis in adult male golden hamsters after transition of the short-day photoperiod (sd; 8 h light: 16 h dark) condition. we confirmed that hypothyroid, which had been induced by administration of thiouracil in drinking water for 4 ... | 2005 | 15699585 |
| preoperative sequential chemotherapy in locally advanced squamous cell carcinoma of the head and neck. | induction chemotherapy may contribute to decreased local and distant recurrences in patients with locally advanced squamous cell carcinoma of the head and neck (scchn) resectable for cure. | 2005 | 15700290 |
| temporal oscillations of thyroid hormones in long term melatonin treated rats. | pharmacological doses of melatonin (0.5 mg/kg body wt. and 1.0 mg/kg body wt.) were chronically administered for 45 days to wistar rats and 24 h rhythms of thyroid stimulating hormone (tsh), triiodothyronine (t3) tetraiodothyronine (t4) and melatonin were studied under semi-natural (ld12:12 h) conditions. exogenous melatonin administration caused delays in the acrophases of t3, t4 and melatonin rhythm itself; whereas advances in the acrophases of tsh were observed, thus indicating chronic admini ... | 2005 | 15700779 |
| radiotherapy for the clinically negative neck in supraglottic laryngeal cancer. | the supraglottic larynx has rich lymphatic drainage, resulting in a high incidence of occult cervical metastases, and the optimal treatment of the clinically uninvolved neck in supraglottic laryngeal cancer remains controversial. selected retrospective series report a greater than 20% regional failure after treatment by radiotherapy alone, and some investigators recommend routine prophylactic neck dissection. we report on our series of patients who received radiotherapy as sole treatment to the ... | 2004 | 15701263 |
| control of bacteriophage t4 tail lysozyme activity during the infection process. | bacteriophage t4 has an efficient mechanism for injecting the host escherichiacoli cell with genomic dna. its gene product 5 (gp5) has a needle-like structure attached to the end of a tube through which the dna passes on its way out of the head and into the host. the gp5 needle punctures the outer cell membrane and then digests the peptidoglycan cell wall in the periplasmic space. gp5 is normally post-translationally cleaved between residues 351 and 352. the function of this process in controlli ... | 2005 | 15701513 |
| down-regulation of s100c is associated with bladder cancer progression and poor survival. | the goal of this study was to identify proteins down-regulated during bladder cancer progression. experimental design: by using comparative proteome analysis and measurement of mrna, we found a significant down-regulation of s100c, a member of the s100 family of proteins, in t24 (grade 3) as compared with rt4 (grade 1) bladder cancer cell lines. moreover, quantification of the mrna level revealed that decreased expression of the protein reflects a low level of transcription of the s100c gene. ba ... | 2005 | 15701847 |
| antenatal glucocorticoids increase early total thyroxine levels in premature infants. | hypothyroxinemia is associated with adverse neonatal outcomes including white matter damage, cerebral palsy, poor neurodevelopment and death. it has become increasingly important to understand the natural history and modifiers of thyroid function in the premature infant. it is standard obstetrical practice to offer antenatal glucocorticoids to pregnant women with threatened preterm delivery. few studies have investigated the effect of antenatal glucocorticoids on neonatal thyroid function. | 2005 | 15703468 |
| effects of novel females and stage of the estrous cycle on sexual behavior in mature beef bulls. | the objective of this experiment was to determine the effects of unrestrained females on sexual behavior of bulls. twelve angus bulls were used in three latin square replicates where sexual interactions between one bull and one female were quantified for each of four 60-min tests (t1, t2, t3, and t4, respectively). all bulls received the following treatments: 1) exposure to four estrual females in sequence (a-b-c-d); 2) exposure to two estrual females in alternating sequence (e-f-e-f); 3) exposu ... | 2005 | 15705758 |
| effects of circuit training on body composition and peak cardiorespiratory responses in patients with moderate to severe traumatic brain injury. | to examine the time course of the changes in body composition and peak cardiorespiratory fitness resulting from routine brain injury rehabilitation program (birp) activities and circuit training in patients with moderate to severe traumatic brain injury (tbi). | 2005 | 15706553 |
| characterization of a wide range base-damage-endonuclease activity of mammalian rps3. | mammalian rps3, a ribosomal protein s3 with a dna repair endonuclease activity, nicks heavily uv-irradiated dna and dna containing ap sites. rps3 calls for a novel endonucleolytic activity on ap sites generated from pyrimidine dimers by t4 pyrimidine dimer glycosylase activity. this study revealed that rps3 cleaves the lesions including ap sites, thymine glycols, and other uv damaged lesions such as pyrimidine dimers. this enzyme does not have a glycosylase activity as predicted from its amino a ... | 2005 | 15707971 |
| posttreatment tnm staging is a prognostic indicator of survival and recurrence in tethered or fixed rectal carcinoma after preoperative chemotherapy and radiotherapy. | to evaluate the prognostic value of the posttreatment tnm stage as a predictor of outcome in locally advanced rectal cancers treated with preoperative chemotherapy and radiotherapy. | 2005 | 15708244 |
| biological activities of conjugated fatty acids: conjugated eicosadienoic (conj. 20:2delta(c11,t13/t12,c14)), eicosatrienoic (conj. 20:3delta(c8,t12,c14)), and heneicosadienoic (conj. 21:2delta(c12,t14/c13,t15)) acids and other metabolites of conjugated linoleic acid. | the elongated form of conjugated linoleic acid (cla), conjugated eicosadienoic acid (cea, conj. 20:2delta(c11,t13/t12,c14)), was generated from cla by liver microsomal fractions. subsequent testing showed that dietary cea significantly reduced body fat, and increased lean mass similar to cla when compared to controls. cea also decreased lipoprotein lipase activity and triacylglyceride, and increased glycerol release in 3t3-l1 adipocytes, correlated with the trans-12,cis-14 isomer, but cea requir ... | 2005 | 15708360 |
| interaction between the t4 helicase-loading protein (gp59) and the dna polymerase (gp43): a locking mechanism to delay replication during replisome assembly. | the t4 helicase-loading protein (gp59) has been proposed to coordinate leading- and lagging-strand dna synthesis by blocking leading-strand synthesis during the primosome assembly. in this work, we unambiguously demonstrate through a series of biochemical and biophysical experiments, including single-molecule fluorescence microscopy, that the inhibition of leading-strand holoenzyme progression by gp59 is the result of a complex formed between gp59 and leading-strand polymerase (gp43) on dna that ... | 2005 | 15709743 |
| evaluation of different culture systems on the in vitro production of bovine embryos. | the objective of this study was to determine the development potential and quality of in vitro produced bovine embryos cultured individually or in groups. after ivm and ivf, presumptive zygotes were cultured in groups or individually, either in drops or in the modified "well of the well" (mwow) system. in experiment 1, four culture systems were utilized: t1: drop in group (control); t2: mwow in groups; t3: mwow individually; and t4: drop individually. cleavage and blastocyst rates at days 6, 7 a ... | 2005 | 15710198 |
| acute licl-treatment affects the cytoplasmic t4 availability and the expression pattern of thyroid hormone receptors in adult rat cerebral hemispheres. | we have previously reported that short-term licl-treatment affects the kinetic characteristics of thyroid hormone binding in adult rat brain (bolaris, s., margarity, m., valcana, t., 1995. effects of licl on triiodothyronine (t3) binding to nuclei from rat cerebral hemispheres. biol. psychiatry 37, 106-111); however, the mechanism underlying the above effects of licl administration is yet to be determined. in this study, the effects of lithium within one day after its administration (5 mmol/kg b ... | 2005 | 15710487 |
| [metachronous cancers after treatment for undifferentiated nasopharyngeal carcinoma]. | to collect second cancers occurring in the head and neck area after treatment by chemotherapy and/or radiotherapy for undifferentiated nasopharyngeal carcinoma in tunisia. | 2004 | 15711481 |
| effect of thyroxine on abnormal pancreatic proteomes of the hypothyroid rdw rat. | a mutation in the thyroglobulin (tg) gene is the primary cause of hereditary dwarfism and hypothyroidism in the rdw rat. despite the tg mutation that causes a tg shortage, rdw rats survive. the present study examines the influences of this condition on the pancreatic proteome. normal control (group 1; n = 19) and rdw rats that did not receive l-thyroxine (t4) (group 2; n = 27) were sacrificed from 4 to 56 weeks after birth. the rdw rats were supplemented either with daily intraperitoneal injecti ... | 2005 | 15712237 |
| physiological and genetic responses of european eel (anguilla anguilla l.) to short-term chromium or copper exposure-influence of preexposure to a pah-like compound. | anguilla anguilla l. (european eel) was exposed for 24 h to chromium (cr-100 microm and 1 mm) or copper (cu-1 and 2.5 microm), with or without a 24-h preexposure to beta-naphthoflavone (bnf-2.7 microm), a polycyclic aromatic hydrocarbon (pah)-like compound, simulating sequential exposure to pahs and heavy metals. plasma cortisol, thyroid-stimulating hormone (tsh), free triiodothyronine (t3), and free thyroxine (t4) were determined in order to assess the effects on endocrine function. plasma gluc ... | 2005 | 15712285 |
| psychosocial factors involved in delayed consultation by patients with head and neck cancer. | in the north of france, a delay in primary consultation has been noted among patients with head and neck cancer. this group is often correlated with lower socioeconomic status and a lack of medical information. therefore, the choice to seek consultation is often influenced by symptoms such as pain and change in the size of tumors in the neck. we studied this delay in seeking consultation, focusing on psychosocial variables such as professional and social background, the involvement of a spouse/p ... | 2005 | 15712292 |
| recombinant human thyrotropin as adjuvant in the treatment of multinodular goiters with radioiodine. | the use of 131i in the treatment of multinodular goiters (mng) is well established. we evaluated the effect of 30 microci 131i (1.11 gbq) in 18 patients with mng with the aid of two injections of 0.1 mg recombinant human tsh (rhtsh), given on d 1 and 2. a dose of 30 microci 131i was given on d 3. tsh, t3, free t4, and thyroglobulin were measured on d 1, 2, 3, 5, 10, 30, 60, 90, and 180, and antithyroid antibodies were measured on d 1, 30, 90, and 180. twenty-four-hour 131i uptake measured 1-3 mo ... | 2005 | 15713700 |
| molecular mechanisms involved in the differential effects of sex steroids on the reproduction and infectivity of taenia crassiceps. | the in vitro exposure of taenia crassiceps cysticerci to 17-beta estradiol (e2) and progesterone (p4) stimulated their reproduction and infectivity. testosterone (t4) and dihydrotestosterone (dht) inhibited their reproduction and reduced their motility and infectivity. e2 and p4 increased, whereas t4 and dht reduced, the expression of parasite c-fos and c-jun and dna synthesis. in vitro exposure of cysticerci to sex steroids before their inoculation into recipient noninfected mice resulted in la ... | 2004 | 15715212 |
| pretreatment serum testosterone level as a predictive factor of pathological stage in localized prostate cancer patients treated with radical prostatectomy. | pretreatment serum level of testosterone (t) is a potential prognostic factor for prostate cancer. the present study was conducted to evaluate the clinical significance of pretreatment serum t level in patients with clinically localized prostate cancer. | 2004 | 15716191 |
| near total laryngectomy: a versatile approach for voice restoration in advanced t3 and t4 laryngeal cancer: functional results and survival. | creation of a tunneled mucosal shunt between the trachea and pharynx that is controlled by remaining intrinsic laryngeal musculature with its nerve supply is an acceptable voice restoration procedure for advanced t3 and t4 laryngeal cancer. such a tunnel will allow unilateral direction of air from lung to pharynx during phonation and will prevent aspiration since deglutition is a vagal mediated response which will induce contraction of tubed laryngeal musculature preventing aspiration. we previo ... | 2004 | 15716993 |
| exacerbations of graves' disease after unilateral adrenalectomy for cushing's syndrome. | cushing's syndrome is characterized by endogenously increased production of glucocorticoids. the activity of immune system is regulated mainly by two systems in the body. glucocorticoids and nf-kappab counteract the effects of each other on the immune system. it has been reported that immune response is exaggerated after the amelioration of cushing's syndrome. we report a rare case of exacerbation of graves' disease after unilateral adrenalectomy for cusing's syndrome. a 50-yr-obese woman with h ... | 2004 | 15717657 |
| expression and localization of caveolins during postnatal development in rat heart: implication of thyroid hormone. | caveolins modulate signaling pathways involved in cardiac development. caveolin-1 exists in two isoforms: the beta-isoform derivates from an alternative translational start site that creates a protein truncated by 31 amino acids, mainly expressed in endothelial cells, whereas caveolin-3 is present in muscle cells. our aim was to define caveolin distribution and expression during cardiac postnatal development using immunofluorescence and western blotting. caveolin-3 sarcolemmal labeling appeared ... | 2005 | 15718400 |
| 2004 asm conference on the new phage biology: the 'phage summit'. | in august, more than 350 conferees from 24 countries attended the asm conference on the new phage biology, in key biscayne, florida. this meeting, also called the phage summit, was the first major international gathering in decades devoted exclusively to phage biology. what emerged from the 5 days of the summit was a clear perspective on the explosive resurgence of interest in all aspects of bacteriophage biology. the classic phage systems like lambda and t4, reinvigorated by structural biology, ... | 2005 | 15720541 |
| protein-dna interactions in the t4 dntp synthetase complex dependent on gene 32 single-stranded dna-binding protein. | our laboratory has reported data suggesting a role for t4 phage gene 32 single-stranded dna-binding protein in organizing a complex of deoxyribonucleotide-synthesizing enzymes at the replication fork. in this article we examined the effects of gene 32 ablation on the association of these enzymes with dna-protein complexes. these experiments showed several deoxyribonucleotide-synthesizing enzymes to be present in dna-protein complexes, with some of these associations being dependent on gene 32 pr ... | 2005 | 15720556 |
| initiation of repair of dna-polypeptide cross-links by the uvrabc nuclease. | although the biochemical pathways that repair dna-protein cross-links have not been clearly elucidated, it has been proposed that the partial proteolysis of cross-linked proteins into smaller oligopeptides constitutes an initial step in removal of these lesions by nucleotide excision repair (ner). to test the validity of this repair model, several site-specific dna-peptide and dna-protein cross-links were engineered via linkage at (1) an acrolein-derived gamma-hydroxypropanodeoxyguanosine adduct ... | 2005 | 15723543 |
| age-related differences of ascaridia galli egg output and worm burden in chickens following a single dose infection. | ninety white chickens (lohmann lsl) were reared under helminth-free conditions and divided into five groups. four groups were artificially infected with 250 embryonated ascaridia galli eggs at the age of 6, 12, 18 or 24 weeks. ten birds were kept as uninfected controls. six and 10 weeks after infection (p.i.), individual faecal egg counts (fec) were performed. the birds were slaughtered after the second sampling and their gastrointestinal tracts were examined for the presence of adult a. galli. ... | 2005 | 15725544 |
| ziprasidone-induced galactorrhea: a case report. | second-generation antipsychotics presumably lack the typical side effects of conventional antipsychotics. | 2005 | 15726024 |
| the evaluation of amifostine for mucosal protection in patients with advanced loco-regional squamous cell carcinomas of the head and neck (scchn) treated with concurrent weekly carboplatin, paclitaxel, and daily radiotherapy (rt). | concurrent chemotherapy and radiation has improved the outcome for patients presenting with locally advanced squamous cell carcinomas of the head and neck (scchn). these improvements have come at a cost of increased treatment-related toxicities. we previously reported the results of a phase ii trial examining the role of concurrent carboplatin, paclitaxel, and daily radiotherapy (rt) in scchn. in an attempt to decrease these side effects, we conducted a prospective phase ii trial evaluating the ... | 2004 | 15726515 |
| a phase ii study to assess the efficacy of amifostine for submandibular/sublingual salivary sparing during the treatment of head and neck cancer with intensity modulated radiation therapy for parotid salivary sparing. | intensity modulated radiation therapy (imrt) allows for relative parotid salivary gland sparing for patients undergoing treatment for head and neck squamous cell cancer, but is less reliable for sparing the submandibular glands. cytoprotection with amifostine (ethyol; medimmune inc, gaithersburg, md) has been shown to decrease rates of acute and late xerostomia in patients undergoing radiation therapy for head and neck squamous cell cancer. the addition of amifostine to imrt may augment parotid ... | 2004 | 15726519 |
| definitive radiotherapy with interstitial implant boost for squamous cell carcinoma of the tongue base. | the purpose of this study was to examine the long-term outcome of a cohort of patients with unresected base of tongue carcinoma who received interstitial brachytherapy after comprehensive external beam radiation therapy. | 2005 | 15726587 |
| survival outcome of patients with nasopharyngeal carcinoma with first local failure: a study by the hong kong nasopharyngeal carcinoma study group. | the purpose of this article is to report the overall survival (os) outcome of patients with nasopharyngeal carcinoma (npc) with local failure who received salvage treatment and to identify prognostic factors for os. | 2005 | 15726589 |
| generation of long tracts of disease-associated dna repeats. | the generation of long uninterrupted dna repeats is important for the study of repeat instability associated with several human genetic diseases, including myotonic dystrophy type 1. however, obtaining defined lengths of long repeats in vitro has been problematic. strand slippage and/or dna secondary structure formation may prevent efficient ligation. for example, a purified (ctg)140.(cag)140 repeat fragment containing 4-bp agca/tgct overhanging ends ligated poorly using t4 or escherichia coli d ... | 2005 | 15727131 |
| improvement of chronic idiopathic urticaria with l-thyroxine: a new tsh role in immune response? | the association between chronic idiopathic urticaria (ciu) and autoimmune thyroiditis (at) is known, as well as major prevalence of antithyroid antibodies in the allergical subjects and other autoimmune diseases. we have evaluated the effects of l-thyroxine on clinical symptoms of ciu in at patients suggesting the hypothesis of a new thyroid-stimulating hormone (tsh) role in immune system. | 2005 | 15727581 |
| sexual dimorphism of thyroid function in newborns with congenital hypothyroidism. | several characteristics of congenital hypothyroidism (ch) from thyroid dysgenesis (ectopy and athyreosis) are sexually dimorphic: girls are more often affected, and boys are twice more likely than girls to have absent knee epiphysis at diagnosis, an indicator of severity of ch. whether the biochemical severity of ch is sexually dimorphic is unknown. we therefore reviewed the charts of all newborns referred to our clinic from 1990 to 2004 because of a tsh greater than 15 mu/liter on newborn scree ... | 2005 | 15728201 |
| assembly of the bacteriophage t4 primosome: single-molecule and ensemble studies. | within replisomes for dna replication, the primosome is responsible for unwinding double-stranded dna and synthesizing rna primers. assembly of the bacteriophage t4 primosome on individual molecules of ssdna or forked dna (fdna) has been studied by using fret microscopy. on either dna substrate, an ordered process of assembly begins with tight 1:1 binding of ssdna-binding protein (gp32) and helicase-loading protein (gp59) to the dna. magnesium adenosine 5'-o-(3-thiotriphosphate) (mgatpgammas) me ... | 2005 | 15728347 |
| thyroxine-binding antibodies inhibit t cell recognition of a pathogenic thyroglobulin epitope. | thyroid hormone-binding (thb) abs are frequently detected in autoimmune thyroid disorders but it is unknown whether they can exert immunoregulatory effects. we report that a thb mab recognizing the 5' iodine atom of the outer phenolic ring of thyroxine (t4) can block t cell recognition of the pathogenic thyroglobulin (tg) peptide (2549-2560) that contains t4 at aa position 2553 (t4(2553)). following peptide binding to the mhc groove, the thb mab inhibited activation of the a(k)-restricted, t4(25 ... | 2005 | 15728526 |
| gender differences in growth hormone response to exercise before and after rhgh administration and the effect of rhgh on the hormone profile of fit normal adults. | exercise is a potent physiological stimulus of gh secretion. we hypothesized that exogenous recombinant human growth hormone (rhgh) administration through an increase in gh and igf-i levels would blunt the gh response to exercise. the aim of the study was to examine and compare the impact of rhgh on the exercise-induced gh response in healthy normal men and women. | 2005 | 15730413 |
| sentinel lymph node biopsy in the management of cutaneous head and neck melanoma. | sentinel lymph node biopsy has revolutionized the surgical management of primary malignant melanoma. most series on sentinel lymph node mapping have concentrated on extremity and truncal melanomas. the head and neck region has a rich and unpredictable lymphatic system. the use of sentinel lymph node mapping in the management of head and neck melanoma is evaluated. the authors conducted a retrospective review of patients treated for clinical stage i and stage ii malignant melanoma of the head and ... | 2005 | 15731669 |
| impact of iodine supplementation of dairy cows on milk production and iodine concentrations in milk. | to determine the effect of iodine supplementation on milk production and iodine concentrations in milk for pasture-fed, seasonally calving dairy cows. | 2005 | 15731828 |
| effect of grazing pasture with a low selenium content on the concentrations of triiodothyronine and thyroxine in serum, and gsh-px activity in erythrocytes in cows in chile. | to determine the effect of grazing pasture that had a low selenium (se) concentration on serum concentrations of triiodothyronine (t3) and thyroxine (t4), and erythrocyte glutathione peroxidase (gsh-px) activity in dairy cows. | 2005 | 15731838 |
| [the role of hemoglobin concentration in the outcome of definitive radiotherapy of the oropharyngeal cancer]. | squamous cell carcinoma of the oropharynx is potentially curative by radiotherapy. the impact on the treatment results have factors related to neoplasm, to the patient and factors related to the method of radiotherapy. the aim of this paper is evaluation of the impact of hemoglobin concentration (hb) on treatment results in these patients. | 2004 | 15732780 |
| supradose intra-arterial cisplatin and concurrent radiation therapy for the treatment of stage iv head and neck squamous cell carcinoma is feasible and efficacious in a multi-institutional setting: results of radiation therapy oncology group trial 9615. | to determine the feasibility of high-dose intra-arterial (ia) cisplatin and concurrent radiation therapy (rt) for head and neck squamous cell carcinoma in the multi-institutional setting (multi-radplat). | 2005 | 15735120 |
| anticancer activity of bacteriophage t4 and its mutant hap1 in mouse experimental tumour models. | previously, we have shown the ability of the bacteriophage t4 and its substrain hap1 (selected for a higher affinity to melanoma cells) to reveal antimetastatic activity in a mouse melanoma model. here, we investigated the potential phage anticancer activity in primary tumour models. | 2004 | 15736444 |
| characterization of cells with proliferative activity after a brain injury. | the cellular responses to a brain injury are important steps in restoring the integrity and function of the brain. proliferating cells, such as reactive astrocytes, oligodendrocyte precursor cells and microglia remodel the injured tissue. to spatially and temporally characterize the initial cellular responses in vivo, proliferating cells were pulse-labeled with brdu soon after (the 2nd day) a cortical cryo-injury, and their fate was investigated by double labeling with an anti-brdu antibody and ... | 2005 | 15737436 |
| architecture of the bacteriophage t4 primosome: electron microscopy studies of helicase (gp41) and primase (gp61). | replication of dna requires helicase and primase activities as part of a primosome assembly. in bacteriophage t4, helicase and primase are separate polypeptides for which little structural information is available and whose mechanism of association within the primosome is not yet understood. three-dimensional structural information is provided here by means of reconstructions from electron microscopic images. structures have been calculated for complexes of each of these proteins with ssdna in t ... | 2005 | 15738414 |
| maternal thyroid hormonal status in preeclampsia. | the physiological changes in the thyroid gland during pregnancy are well understood but only a few reports provide information about thyroid function in complicated pregnancies. | 2005 | 15738611 |
| [present treatment strategies for rectal carcinoma]. | in the last ten years, considerable progress has been achieved in the treatment of rectal cancer. according to improved interdisciplinary staging, rectal carcinomas can be treated based on a stage-dependent concept: "low-risk" pt1 (g1/g2) carcinomas can be cured by local full wall excision, while "high-risk" pt1 (g3/g4) and pt2 carcinomas require transabdominal resection. in contrast, locally advanced rectal cancers in cuicc-ii/-iii stages (t3/t4 or n(+)) should receive long-term, 5-fu-based, ne ... | 2005 | 15739059 |
| clinical and molecular prognostic factors in operable laryngeal cancer. | many factors affect the prognosis in operable laryngeal squamous cell carcinoma (lscc). many clinical factors have been implicated in tumor recurrence and poor survival of the patients. the aim of the present study is to investigate the demographic, clinical and histological characteristics as prognostic factors. moreover, our aim is to analyze the role of modern molecular biomarkers in the prognosis of patients with lscc. one hundred patients with operable laryngeal carcinoma underwent surgery ... | 2005 | 15739081 |
| dimeric dutpases, hise, and mazg belong to a new superfamily of all-alpha ntp pyrophosphohydrolases with potential "house-cleaning" functions. | structure-guided analysis of the new dimeric dutpase family revealed its sequence relationship to the phage t4 dctpase, phosphoribosyl-atp pyrophosphatase hise, ntp pyrophosphatase mazg, and several uncharacterized protein families, including the human protein xtp3tpa (rs21-c6), which is overexpressed in embryonic and cancer cells. comparison with the recently determined structure of a mazg-like protein from sulfolobus solfataricus supported the unification of these enzymes in one superfamily of ... | 2005 | 15740738 |
| mechanistic studies of the t4 dna (gp41) replication helicase: functional interactions of the c-terminal tails of the helicase subunits with the t4 (gp59) helicase loader protein. | we compare the activities of the wild-type (gp41wt) and mutant (gp41delta c20) forms of the bacteriophage t4 replication helicase. in the gp41delta c20 mutant the helicase subunits have been genetically truncated to remove the 20 residue c-terminal tail peptide domains present in the wild-type enzyme. here, we examine the interactions of these helicase forms with the t4 gp59 helicase loader and the gp32 single-stranded dna binding proteins, both of which are physically and functionally coupled w ... | 2005 | 15740739 |
| leptin treatment during lactation increases transfer of iodine through the milk. | we have previously shown that protein restriction during lactation is associated with changes in iodine secretion into the milk and that a pup's serum leptin concentration was increased at the end of lactation. so, here we evaluate whether leptin treatment during lactation affects iodine transfer through the milk to the pups. lactating rats were divided into two groups: the leptin (lep) group, single injected with recombinant rat leptin (8 microg/100g of body weight, daily for 3 consecutive days ... | 2005 | 15741047 |
| [etiological assessment of hyperthyrotropinemia in children with down's syndrome]. | to study the prevalence of increased tsh level and its probable cause in children with down's syndrome treated at policlínica antônio cândido. | 2005 | 15742091 |
| antitumor activity of bacteriophages in murine experimental cancer models caused possibly by inhibition of beta3 integrin signaling pathway. | bacteriophages (phages) as bacterial viruses are generally believed to have no intrinsic tropism for mammalian cells. in this study the interactions between phages and various eukaryotic cells were investigated. binding of phages to the membranes of cancer and normal blood cells was observed. moreover, it was shown that the wild-type phage t4 (wtt4) and its substrain hap1 with enhanced affinity for melanoma cells inhibit markedly and significantly experimental lung metastasis of murine b16 melan ... | 2004 | 15745047 |