| differences in health-related quality of life of prostate cancer patients based on stage of cancer. | understanding medical factors that influence quality of life for men with prostate cancer is an important goal. this study analysed the relationship between cancer stage and quality of life, including measures of physical and psychological well-being. | 2004 | 15386638 |
| a long-term study on the expansion effects of the cervical-pull facebow with and without rapid maxillary expansion. | this study evaluates the long-term stability of maxillary expansion achieved by widening the inner bow of a facebow, with or without concurrent rapid maxillary expansion (rme) (haas type), followed by treatment with fixed edgewise appliances. the parent sample included 154 nonextraction patients who started their orthodontic treatment during a defined time period. the exclusion criteria reduced the number of patients to 61 in the cervical-pull facebow group (cfb) and 41 in the rme-cfb group. all ... | 2004 | 15387020 |
| the selenium requirement of the puppy. | current selenium (se) recommendations for the puppy are based on extrapolation from other species (0.11 mg se/kg diet). the purpose of this study was to experimentally determine the se requirement in puppies. thirty beagle puppies (average = 8.8 weeks old) were utilized in a randomized complete block design with age, litter and gender used as blocking criteria. puppies were fed a low se (0.04 mg se/kg diet) torula yeast-based diet for 14 days (pre-test period) after which this same diet was supp ... | 2004 | 15387850 |
| use of an ion-binding site to bypass the 1000-atom limit to structure determination by direct methods. | proteins with more than 1000 non-h atoms and without heavy-atom prosthetic groups are very difficult to solve by ab initio direct methods. t4 lysozyme is being used to explore these limits. the protein has 1309 non-h atoms, seven s atoms, no disulfide bonds and no heavy-atom prosthetic group. it is recalcitrant to structure determination by direct methods using x-ray diffraction data to 0.97 a. it is shown here that it is possible to obtain a truly ab initio structure determination of a variant ... | 2004 | 15388918 |
| pectoralis major and other myofascial/myocutaneous flaps in head and neck cancer reconstruction: experience with 437 cases at a single institution. | pectoralis major and other myofascial/myocutaneous flaps have been recognized as important reconstructive methods in head and neck cancer surgery. even with the worldwide use of free flaps, they are still the mainstay reconstructive procedures in many centers. | 2004 | 15390191 |
| the influence of the pattern of mandibular invasion on recurrence and survival in oral squamous cell carcinoma. | controversy exists over the predictive value of the presence and pattern of tumor invasion of the mandible in oral squamous cell carcinoma (scc). many authors have questioned increasing the classification of small tumors to t4 on the basis of mandibular invasion alone. there are little data on the influence of the pattern of invasion on prognosis. | 2004 | 15390204 |
| chemical studies in host-virus interactions; a comparison of some properties of three mutant pairs of bacterial viruses, t2r and t2r, t4r and t4r, t6r and t6r. | various chemical and physiological aspects of the reproductive cycles of r(+) and r strains of t2, t4, and t6 viruses have been examined and compared. these include the ultraviolet absorption spectra in which differences between r and r(+) strains were not observed, though they were obtained in the case of t2, t4, and t6. adsorption of t4 and t6 was found to require the adsorption cofactor l-tryptophane. among the r and r(+) strains of these viruses limiting tryptophane requirements for adsorpti ... | 1950 | 15422088 |
| effect of hypothyroidism on the blood lipid response to higher dietary fat intake in mares. | blood lipid and lipoprotein concentrations were measured and compared between euthyroid and thyroidectomized mares on low-fat or high-fat diets to test the hypothesis that hypothyroidism alters the blood lipid response to higher dietary fat intake. four healthy adult mares and four adult mares that had been thyroidectomized 3 to 6 mo earlier were placed on low-fat or high-fat diets according to a replicated 2 x 2 latin square design consisting of two 5-wk feeding periods separated by a 2-wk wash ... | 2004 | 15446481 |
| nutrition of very low birth weight infants fed human milk with or without supplemental trace elements: a randomized controlled trial. | very low birth weight infants (<1500 g) have high nutritional needs. deficiencies of minerals, trace elements (especially zinc) may develop as a result of rapid growth, low body stores and low content of these substances in human milk we hypothesized that fortification of human milk might prevent deficiencies. | 2004 | 15448423 |
| thyroid hormone participates in the regulation of neural stem cells and oligodendrocyte precursor cells in the central nervous system of adult rat. | oligodendrocyte development and myelination are under thyroid hormone control. in this study we analysed the effects of chronic manipulation of thyroid status on the expression of a wide spectrum of oligodendrocyte precursor cells (opcs) markers and myelin basic protein (mbp) in the subventricular zone (svz), olfactory bulb and optic nerve, and on neural stem cell (nsc) lineage in adult rats. hypo- and hyperthyroidism were induced in male rats, by propyl-thio-uracil (ptu) and l-thyroxin (t4) tre ... | 2004 | 15450085 |
| unique ligation properties of eukaryotic nad+-dependent dna ligase from melanoplus sanguinipes entomopoxvirus. | the eukaryotic melanoplus sanguinipes entomopoxvirus (msepv) genome reveals a homologous sequence to eubacterial nicotinamide adenine dinucleotide (nad(+))-dependent dna ligases [j. virol. 73 (1999) 533]. this 522-amino acid open reading frame (orf) contains all conserved nucleotidyl transferase motifs but lacks the zinc finger motif and brct domain found in conventional eubacterial nad(+) ligases. nevertheless, cloned msepv ligase seals dna nicks in a nad(+)-dependent fashion, while adenosine 5 ... | 2004 | 15450174 |
| directional ligation of long-flanking homology regions to selection cassettes for efficient targeted gene-disruption in candida albicans. | pcr-product directed gene disruption with a marker cassette having short homology regions is often used in candida albicans. however, it is quite inefficient due to the high frequency of non-homologous recombination at non-targeted loci, which necessitates extensive screening to identify the correct disruptants. thus, many pcr-based methods to introduce long flanking homology regions have been developed to increase the frequency of integration at the targeted loci. however, these methods are not ... | 2004 | 15450191 |
| mediastinoscopic ultrasonography (mus). | correct pre-therapeutic t4 staging is mandatory for neo-adjuvant studies and for the decision on surgical therapy of high-risk patients. t4-staging of centrally located lung-cancer by means of non-invasive imaging techniques is either of low accuracy (ct and nmr) or important regions are not accessible due to air interference with the tracheo-bronchial tree (trans-esophageal-endosonography, tee). we here describe for the first time the new technique of mediastinoscopic ultrasonography (mus). a f ... | 2004 | 15450590 |
| bag-1 expression as a prognostic factor in tongue squamous cell carcinomas. | to investigate the prognostic significance of the antiapoptotic protein bag-1. in addition, the relationship between bag-1 expression, other apoptosis-related and proliferative parameters. | 2004 | 15454773 |
| acetylcholine-induced relaxation of rabbit basilar artery in vitro is rapidly reduced by reactive oxygen species in acute hyperglycemia: role of nadph oxidase. | we examined the effects of acute hyperglycemia on the function of rabbit cerebral arteries in vitro. it was hypothesized that increased formation of reactive oxygen species (ros) could occur, which could explain how hyperglycemia aggravates certain pathologic situations such as cerebral ischemia. three-millimeter basilar artery segments were incubated in either normoglycemic (ng, 5.5 mm d-glucose) or hyperglycemic (hg, 25 mm d-glucose) solution containing 3.10(-6) m indomethacin. after 90 minute ... | 2004 | 15454861 |
| [membranous nephropathy associated to autoimmune thyroiditis, chronic pancreatitis and suprarrenal insufficiency]. | a 33 year old female was admitted to the hospital to study aedema and bocio, a nephrotic syndrome was diagnosed and the renal biopsy demonstrated membranous glomerulonephritis, stage ii. she was also diagnosed of hashimoto's autoinmmune thyroiditis: tsh (41.5 uul/ml), t4 (0.07 ng/dl), antithyroglobuline (1/2560) and antimicrosome (1/6400). four year latter she was diagnosed of autoinmmune pancreatitis, without evidence of diabetes mellitus or exocrine pancreatic insufficiency. eight years latter ... | 2004 | 15455500 |
| the double rib contour sign (drcs) in lateral spinal radiographs: aetiologic implications for scoliosis. | all lateral spinal radiographs in idiopathic scoliosis show a drc sign of the thoracic cage, a radiographic expression of the rib hump. the outline of the convex overlies the contour of the concave ribs. the aim of this study is to assess this drc sign in children with and without late onset idiopathic scoliosis (lois) with 10 degrees -20 degrees cobb angle, and to examine whether in scoliosis the deformity of the thorax or that of the spine develops first. | 2002 | 15456003 |
| intra-operative measurement of vertebral bone strength. | a significant complication of surgical correction of the deformed spine is pull out of the vertebral hooks or screws. this complication can be partly attributed to poor bone stock. currently, there are few methods available for surgeons to assess the mechanical strength and stiffness of the vertebra, and even fewer methods that provide in-vivo measurements. an "upbiter" is often used to form a seat in the lamina for the hook. a typical upbiter was modified and instrumented with strain gauges to ... | 2002 | 15456055 |
| soft docking and multiple receptor conformations in virtual screening. | protein conformational change is an important consideration in ligand-docking screens, but it is difficult to predict. a simple way to account for protein flexibility is to soften the criterion for steric fit between ligand and receptor. a more comprehensive but more expensive method would be to sample multiple receptor conformations explicitly. here, these two approaches are compared. a "soft" scoring function was created by attenuating the repulsive term in the lennard-jones potential, allowin ... | 2004 | 15456251 |
| a muc1 tandem repeat reporter protein produced in cho-k1 cells has sialylated core 1 o-glycans and becomes more densely glycosylated if coexpressed with polypeptide-galnac-t4 transferase. | a recombinant mucin o-glycosylation reporter protein, containing 1.7 tandem repeats (trs) from the transmembrane mucin muc1, was constructed. the reporter protein, muc1(1.7tr)-igg2a, was produced in cho-k1 cells to study the glycosylation of the muc1 tr and the in vivo role of polypeptide-galnac-t4 glycosyltransferase. n-terminal sequencing of muc1(1.7tr)-igg2a showed that all five potential o-glycosylation sites within the tr were used, with an average density of 4.5 glycans per repeat. the lea ... | 2005 | 15456735 |
| end labeling procedures: an overview. | there are two ways to label a dna molecular; by the ends or all along the molecule. end labeling can be performed at the 3'- or 5'-end. labeling at the 3' end is performed by filling 3'-end recessed ends with a mixture or labeled and unlabeled dntps using klenow or t4 dna polymerases. both reactions are template dependent. terminal deoxynucleotide transferase incorporates dntps at the 3' end of any kind of dna molecule or rna. labels incorporated at the 3'-end of the dna molecule prevent any fur ... | 2004 | 15456965 |
| study of the rib cage deformity in children with 10 degrees-20 degrees of cobb angle late onset idiopathic scoliosis, using rib-vertebra angles--aetiologic implications. | the aim of the study is to compare the rib-vertebra angles (rvas) between children with 10 degrees - 20 degrees of cobb angle late onset idiopathic scoliosis (lois) and non-scoliotic children. | 2002 | 15457688 |
| lateral spinal profile in school-screening referrals with and without late onset idiopathic scoliosis 10 degrees-20 degrees. | the aim of this report is a) to study the lateral spinal profile, (lsp), in school-screening referrals with and without late onset idiopathic scoliosis of small curves 10 degrees - 20 degrees cobb angle and b) to validate lsp's aetiological importance in idiopathic scoliosis pathobiomechanics. | 2002 | 15457689 |
| surgical management of a congenital kyphotic deformity in an adolescent. | this is a case of an adolescent with kyphoscoliosis due to congenital partially segmented vertebrae t12, l1, l2 who was treated operatively by a back-front-back, one stage operation. a 16 year old patient neurologically intact with a rounded gibbous in the lower thoracic region and a mild scoliotic element had no other congenital anomaly. his kyphotic deformity was 85 degrees measured with the cobb method. preoperatively, a ct and mri scan of the spine was performed and a three-level anterolater ... | 2002 | 15457775 |
| multi-organic endocrine disrupting activity of the uv screen benzophenone 2 (bp2) in ovariectomized adult rats after 5 days treatment. | the chemical industry has developed sun protection factor products, which contain a variety of so-called "uv screens", among others, benzophenones (bp). based on the structure it can be assumed, that the variant bp2 may be a potent estrogenic endocrine disrupter (ed). only very limited data are available in the literature about such action of bp2, which focussed on the uterotrophic effect in immature rats. however, determination of ed activity in the uterus is only a restricted approach with the ... | 2004 | 15458793 |
| endocrine active compounds affect thyrotropin and thyroid hormone levels in serum as well as endpoints of thyroid hormone action in liver, heart and kidney. | to assess interference with endocrine regulation of the thyroid axis, rats (female, ovariectomised) were treated for 12 weeks with the suspected endocrine active compounds (eac) or endocrine disrupters (ed) 4-nonylphenol (np), octyl-methoxycinnamate (omc) and 4-methylbenzylidene-camphor (4-mbc) as well as 17beta-estradiol (e2) and 5alpha-androstane-3beta,17beta-diol (adiol) on the background of a soy-free or soy-containing diet, and endpoints relevant for regulation via the thyroid axis were mea ... | 2004 | 15458794 |
| long-term follow-up of a pilot phase ii study with neoadjuvant epidoxorubicin, etoposide and cisplatin in gastric cancer. | the prognosis in t3-t4 or n+ gastric cancer is dismal, and the role of adjuvant therapy remains uncertain. neoadjuvant chemotherapy could improve both resectability and survival. here, we report the results of the long-term follow-up of a pilot study aimed at evaluating a neoadjuvant treatment in a group of patients carefully staged by computed tomography (ct), endoscopic ultrasound and laparoscopy. | 2004 | 15459495 |
| evaluation of arm-leg coordination in flat breaststroke. | this study proposes a new method to evaluate arm-leg coordination in flat breaststroke. five arm and leg stroke phases were defined with a velocity-video system. five time gaps quantified the time between arm and leg actions during three paces of a race (200 m, 100 m and 50 m) in 16 top level swimmers. based on these time gaps, effective glide, effective propulsion, effective leg insweep and effective recovery were used to identify the different stroke phases of the body. a faster pace correspon ... | 2004 | 15459828 |
| co2 laser surgery: a larynx preservation alternative for selected hypopharyngeal carcinomas. | transoral co2 laser surgery (tls) has demonstrated good oncologic results and low morbidity in the treatment of selected laryngeal carcinomas, but experience in hypopharyngeal carcinomas (hc) is limited. the aim of this study was to evaluate the usefulness of tls in the treatment of selected hc. | 2004 | 15459928 |
| impact of data encoding and thyroids dysfunctions. | in medical environments it is usual to previously encode some variables following medical criteria. in the context of thyroids dysfunctions, the levels of the hormones t3, t4 or tsh are usually treated as low, normal or high instead of using their numerical form, and this is a very common practice in other items. in medical environments it is also frequent to need a clustering process to analyze data. clus-tering algorithms use always some distance or similarity coefficient to decide which eleme ... | 2002 | 15460743 |
| [the lanthanide fluorescence immunoassay of the total thyroxin in dried bloodstains on paper]. | the lanthanide fluorescence immunoassay was elaborated for quantitative determination of the total thyroxin t4 in bloodstain dried in filter paper; the fields of its clinical application were defined. the method is based on the hardphase concurrent immunoassay with specific monoclonal antibodies to t4 marked by chelates of europium ions and with conjugate of the t3 heterologous hapten sorbed in plate holes with bovine serum albumin. measurements of the fluorescence intensity were made by a fluor ... | 2004 | 15460993 |
| on the solution structure of the t4 sliding clamp (gp45). | examination by time-resolved fluorescence spectroscopy of the trimeric bacteriophage t4 clamp protein labeled across its three subunit interfaces with a fluorescence resonance energy transfer (fret) pair indicates that the clamp exists in just one state in solution, with one open and two closed interfaces. this is in contrast to what is observed in the x-ray crystal structure. the population distribution of the trfret distance is bimodal, giving 67% as 17 a and 33% as 42 a. this leads to the con ... | 2004 | 15461444 |
| thyroid hormone transport is disturbed in erythrocytes from patients with chronic renal failure on hemodialysis. | to now, there are no studies reporting whether thyroid hormones (ths) transport play a role in thyroid hormone dysfunction observed in chronic renal failure (crf). therefore, the aim of this study was to investigate the transport of ths in erythrocytes from patients with crf on hemodialysis (hd). | 2004 | 15462116 |
| [the supracricoid laryngectomy with cricohyoidopexy. carcinological and functional results. 23 cases report of the centre a. lacassagne (nice)]. | this study is to estimate the survival results, the morbidity and the functional consequences of the supracricoid laryngectomy with cricohyoïdopexy (sl-chp). | 2004 | 15462171 |
| vitamin e prevents deleterious effects of di (2-ethyl hexyl) phthalate, a plasticizer used in pvc blood storage bags. | vitamin e administration prevented dehp induced deleterious effects like (i) degenerative changes in the brain and thyroid, (ii) decrease in the activity of neuronal membrane na+ - k+ atpase, (iii) decrease in the concentration of insulin, cortisol and tsh, and (iv) the increase in t3 and t4 in female albino rats. the results suggest use of vitamin e to prevent harmful effects of repeated transfusion of dehp containing blood as in thalassemia patient. the possibility of using vitamin e to preven ... | 2004 | 15462179 |
| combined resection of superior vena cava for lung carcinoma: prognostic significance of patterns of superior vena cava invasion. | combined resection of the superior vena cava (svc) for lung carcinoma remains challenging in terms of technical aspect and prognosis. we attempted to clarify the surgical outcome of combined resection and reconstruction of the svc for lung carcinoma. | 2004 | 15464467 |
| escherichia coli detection by gfp-labeled lysozyme-inactivated t4 bacteriophage. | escherichia coli has been used as an indicator of the fecal contamination of water and food, identifying potential health hazards. in this study, an e. coli-specific bacteriophage, t4, was used to detect e. coli bacteria. the t4 phage small outer capsid (soc) protein was used to present green fluorescent protein (gfp), an easily detectable marker protein, on the phage capsid. to inactivate phage lytic activity, we used the t4e(-) phage, which does not produce the lysozyme responsible for host ce ... | 2004 | 15464594 |
| vasoactive intestinal peptide can modulate immune and endocrine responses during lipopolysaccharide-induced acute inflammation. | in many studies, it has been reported that vasoactive intestinal peptide (vip) may play an important role in modulation of the immunological response. vip can be produced by immunological cells, and also the receptors for this neuropeptide are present in many of these cells. the aim of our study was to estimate the effects of the administration of exogenous vip on serum concentrations of proinflammatory cytokines [interleukin (il)-6 and tumor necrosis factor (tnf)-alpha] and an anti-inflammatory ... | 2004 | 15467350 |
| efficacy of routine bilateral neck dissection in the management of supraglottic cancer. | in a previous study, we reported that the contralateral undissected neck was the most common site of failure in patients treated for squamous cell carcinoma of the supraglottic larynx. since then, we have altered our treatment of all patients with t2-t4 supraglottic cancer and selective t1 cases to include routine bilateral neck dissection. in the present study, we compare the long-term efficacy of routine bilateral neck dissections to historic controls in the treatment of patients with supraglo ... | 2004 | 15467622 |
| is the delay in starting postoperative radiotherapy a key factor in the outcome of advanced (t3 and t4) laryngeal cancer? | to identify factors influencing the outcome of postoperative radiotherapy in patients with advanced laryngeal cancer. | 2004 | 15467623 |
| trimester-specific reference intervals for thyroxine and triiodothyronine in pregnancy in iodine-sufficient women using isotope dilution tandem mass spectrometry and immunoassays. | accurate assessment of the pregnant woman's thyroid status is critical, for both the initiation of thyroid hormone therapy and for the adjustment of thyroid hormone dose in those already receiving thyroid hormone. trimester-specific intervals are especially important during pregnancy when thyroid insufficiency may be associated with adverse obstetric outcome and fetal neurodevelopmental deficits. we defined pregnancy-specific reference intervals for thyroxine (t4) and 3,5,3'-triiodothyronine (t3 ... | 2004 | 15469872 |
| type 2 iodothyronine selenodeiodinase is expressed throughout the mouse skeleton and in the mc3t3-e1 mouse osteoblastic cell line during differentiation. | thyroid hormone affects multiple aspects of bone metabolism, but little is known about thyroid hormone deiodination in bone cells except that cultures of skeletal cells and bone organ express types 1 and 2 iodothyronine deiodinases (d1 and d2) mrnas. in the present study, outer ring deiodination (ord) activity was detected in bone extracts of multiple sites of the mouse skeleton, bone marrow, and the mc3t3-e1 osteoblastic cell line. in all tissues, ord was detected using 125i-rt3 or 125i-t4 as s ... | 2005 | 15471965 |
| association of serum paraoxonase activity with insulin sensitivity and oxidative stress in hyperthyroid and tsh-suppressed nodular goitre patients. | low serum paraoxonase (pon) activity is thought to be a risk factor for the development of atherosclerosis. the present study was designed to evaluate pon1 activity and its relationship with preatherosclerotic markers such as lipid peroxidation and insulin resistance in hyperthyroid patients before and after propylthiouracil (ptu) treatment and in subjects with iatrogenic subclinical hyperthyroidism. | 2004 | 15473886 |
| developmental changes of thyroid hormones in the fathead minnow, pimephales promelas. | the fathead minnow is widely used in ecotoxicological studies and such investigations have begun to focus on potential disruption of the thyroid axis. however, normal levels of thyroxine (t4) and 3,5,3'-triiodothyronine (t3) and their developmental patterns are unknown. to provide these baseline data, radioimmunoassays were developed and validated for analysis of t4 and t3 after extraction from plasma or whole fish. female fish showed consistently higher plasma levels of t4 than male fish. analy ... | 2004 | 15474536 |
| histone deacetylase 1 mrna expression in lung cancer. | histone deacetylases (hdacs) play a crucial role in tumorigenesis, however, the expression status of hdacs in lung cancer tissues has not been reported. we have investigated that hidac 1 mrna levels and other clinico-pathological data, including mta 1 mrna expression in lung cancer. the study included 102 lung cancer cases. the hdac1 mrna levels were quantified by real time reverse transcription-polymerase chain reaction (rt-pcr) using lightcycler (roche molecular biochemicals, mannheim, germany ... | 2004 | 15474665 |
| delayed spinal cord injury following electrical burns: a 7-year experience. | although delayed spinal cord injury following high-voltage electrical burn is not a life-threatening sequelae, complete recovery is not the rule and the morbidity is high. in this study, we conducted a detailed analysis of clinical characteristics, radiographic findings and clinical outcomes in 13 patients with delayed spinal cord injury following electrical burns. the following features were notable. in 11 patients whose entry sites were the head and neck area, paraplegia was detected in cases ... | 2004 | 15475144 |
| chemotherapy is more effective in patients with breast cancer not expressing steroid hormone receptors: a study of preoperative treatment. | the purpose of this research was to identify factors predicting response to preoperative chemotherapy. | 2004 | 15475452 |
| interleukin-18, a proinflammatory cytokine, contributes to the pathogenesis of non-thyroidal illness mainly via the central part of the hypothalamus-pituitary-thyroid axis. | proinflammatory cytokines are involved in the pathogenesis of non-thyroidal illness (nti), as shown by studies with il-6-/- and il-12-/- mice. interleukin (il)-6 changes peripheral thyroid hormone metabolism, and il-12 seems to be involved in the regulation of the central part of the hypothalamic-pituitary-thyroid (hpt) axis during illness. il-18 is a proinflammatory cytokine which shares important biological properties with il-12, such as interferon (ifn)-gamma-inducing activity. | 2004 | 15476451 |
| phage-induced change in the stability of mrnas. | the stability of mrna in escherichia coli cells changed after phage t4 infection. stable e. coli mrnas such as lpp and ompa were drastically destabilized immediately after infection. in contrast, t4 phage soc mrna that had been unstable before infection became stabilized after infection. the host rnases e and g both contributed to the destabilization of these mrnas. accordingly, these rnases may alter their target rnas before and after infection. an rna chaperon, hfq, and polyadenylation at 3' e ... | 2004 | 15476881 |
| acanthamoeba keratitis in non-contact lens wearers in india: dna typing-based validation and a simple detection assay. | to establish that the protozoan acanthamoeba is one of the causative organisms associated with non-contact lens-related keratitis in the indian population and to develop a simple and sensitive diagnostic assay for clinical testing. | 2004 | 15477452 |
| urolithiasis associated with indinavir in a patient with spinal cord injury. | to report a case of indinavir-induced urolithiasis, and the greater risk of this occurrence in individuals with spinal cord injury (sci) who require fluid restriction for an intermittent catheterization program (icp). | 2004 | 15478531 |
| neonatal chemical hypothyroidism in nigeria. | to investigate the level of neonatal chemical hypothyroidism (nch), thyroid function was measured in the cord blood of 271 neonates in an area with a high prevalence of endemic goitre, bassa (n = 140), and a nonendemic area, jos (n = 131), in plateau state, nigeria. nch was defined as t4 < 40 nmol/l and tsh > 49 mu/l and borderline compensated nch as t4 31-50 nmol/l and tsh 41-49 mu/l. nch was detected in 16.4% of neonates in bassa and in 3.8% in jos. borderline compensated nch was detected in a ... | 2004 | 15479573 |
| vertebral wedging characteristic changes in scoliotic spines. | a morphometric analysis of vertebral wedging in vertebrae from scoliotic specimens. | 2004 | 15480123 |
| long term changes in serum t4, t3, and tsh in benign thyroid disease: proof of a narrow individual variation. | the diagnosis of abnormalities of thyroid function is generally based on the measurement of thyroid hormones and tsh in blood. the recommended reference ranges for serum t4 and t3 as well as tsh are quite wide as the result of large differences in thyroid function tests in healthy persons. it has been proven that the individual variation within an individual is small, compared with the variation between individuals. we investigated long term variations of these parameters in patients with and wi ... | 2004 | 15480504 |
| isolation and characterization of a cellulolytic geobacillus thermoleovorans t4 strain from sugar refinery wastewater. | a novel, cellulolytic, bacterial thermophilic strain, t4, was isolated from sugar refinery wastewater in southern taiwan. this isolate, a gram-negative, motile, aerobically growing sporulating rod, can secrete thermostable endocellulase (endo-1,4-beta-d-glucanase, ec 3.2.1.4) and hydrolyze carboxymethylcellulose (cmc), phosphoric acid-swollen cellulose, avicel, filter paper, and salicin. when strain t4 was grown in cmc medium, the cellulolytic enzyme activity in culture supernatants was stable u ... | 2004 | 15480864 |
| free thyroxine measured with equilibrium dialysis and nine immunoassays decreases in late pregnancy. | we measured free thyroxine in sera from 29 women in the ninth month of pregnancy. we used the reference method, equilibrium dialysis, and nine immunoassays. the bias between immunoassay and dialysis results was insignificant or modest. with all methods, the results were in the lower part of the non-pregnant female reference interval or below the lower limit of this interval: 10 results with the equilibrium dialysis assay and from 4 to 18 results with the nine immunoassays. method-specific refere ... | 2004 | 15481634 |
| case report: spontaneous spinal epidural haematoma during pregnancy: case report and review of the literature. | spontaneous epidural haematoma is rare in pregnancy and only five cases have been reported. we present a case of a 31-year-old female g2p1 who at 32 weeks of gestation developed progressive ascending paralysis and numbness to a level of approximately t4. an urgent mri of the spine was performed, which demonstrated a posterior epidural lesion at t1-t4 level. the lesion showed signal changes consistent with an epidural haematoma in the hyperacute stage. an emergency cesarean section was performed ... | 2004 | 15483004 |
| [factors associated with postoperative mortality following gastric adenocarcinoma surgery at the edgardo rebagliati martins hospital]. | this study is a retrospective, descriptive and observational evaluation aimed at defining the factors associated with postoperative mortality due to gastric adenocarcinoma and evaluating postoperative morbidity at the edgardo rebagliati martins hospital. | 2004 | 15483682 |
| performance of mouse lines divergently selected for heat loss when exposed to different environmental temperatures. i. reproductive performance, pup survival, and metabolic hormones. | mouse populations differing in metabolic rate have been developed through selection for high (mh) and low (ml) heat loss, along with the unselected controls (mc). objectives of the study were to compare the mh, ml, and mc lines for reproductive performance, pup survival, and metabolic hormones when reared at 12, 22, and 31 degrees c, and to search for line x environment interactions. conception and litter size were recorded on the parent generation mice introduced to the environments at 11 wk of ... | 2004 | 15484937 |
| effect of se on selenoprotein activity and thyroid hormone metabolism in beef and dairy cows and calves. | although se is essential for antioxidant and thyroid hormone function, factors influencing its requirement are not well understood. a survey and two experiments were conducted to determine the influence of cattle breed and age on selenoprotein activity and the effect of maternal se supplementation on cow and calf selenoprotein activity and neonatal thyroid hormone production. in our survey, four cowherds of different ages representing three breeds were bled to determine the influence of breed an ... | 2004 | 15484952 |
| the sequences and activities of regb endoribonucleases of t4-related bacteriophages. | the regb endoribonuclease encoded by bacteriophage t4 is a unique sequence-specific nuclease that cleaves in the middle of ggag or, in a few cases, ggau tetranucleotides, preferentially those found in the shine-dalgarno regions of early phage mrnas. in this study, we examined the primary structures and functional properties of regb ribonucleases encoded by t4-related bacteriophages. we show that all but one of 36 phages tested harbor the regb gene homologues and the similar signals for transcrip ... | 2004 | 15486207 |
| [recurrent micro-satellite stable colonic cancer: prolonged survival of 16 years without adjuvant therapy]. | long-term survival in malignant disease is often linked to intensified therapeutic interventions. we report the case of a colonic cancer in a 78 years old female patient, who underwent her first operation in 1987 for a symptomatic t4 carcinoma. since then, the patient has always denied any form of follow-up examination and adjuvant therapy. recently, she has undergone her fourth operation, which for the first time demonstrated peritoneal carcinosis, and is still in very good health.clinical expe ... | 2004 | 15486798 |
| extending low-dose epidural analgesia for emergency caesarean section using ropivacaine 0.75%. | we compared ropivacaine 0.75% and bupivacaine 0.5% for extending low-dose epidural analgesia for emergency caesarean section, using a prospective double-blind randomised controlled trial design. the trial was halted after 45 patients were studied (23 ropivacaine; 22 bupivacaine) because bupivacaine was replaced by levobupivacaine in our unit. time to reach t4 for loss of cold sensation was similar in both groups, although analgesic supplementation was required less often in the ropivacaine group ... | 2004 | 15488058 |
| lactobacillus plantarum bacteriophage lp65: a new member of the spo1-like genus of the family myoviridae. | the virulent lactobacillus plantarum myophage lp65 was isolated from industrial meat fermentation. tail contraction led to reorganization of the tail sheath and the baseplate; a tail tube was extruded. in ultrathin section the phage adsorbed via its baseplate to the exterior of the cell, while the tail tube tunneled through the thick bacterial cell wall. convoluted membrane structures were induced in the infected cell. progeny phage was detected 100 min postinfection, and lysis occurred after ex ... | 2004 | 15489418 |
| moda and modb, two adp-ribosyltransferases encoded by bacteriophage t4: catalytic properties and mutation analysis. | bacteriophage t4 encodes three adp-ribosyltransferases, alt, moda, and modb. these enzymes participate in the regulation of the t4 replication cycle by adp-ribosylating a defined set of host proteins. in order to obtain a better understanding of the phage-host interactions and their consequences for regulating the t4 replication cycle, we studied cloning, overexpression, and characterization of purified moda and modb enzymes. site-directed mutagenesis confirmed that amino acids, as deduced from ... | 2004 | 15489438 |
| thyroid hormone binding protein abnormalities in patients referred for thyroid disorders. | thyroid hormone binding protein (thbp) abnormalities are the major cause of discordance in commonly performed total thyroxine (t4) and thyrotropin (tsh) estimations, though these do not interfere with thyroid hormone action. determination of such abnormalities in patients showing discordant thyroid function tests (tfts) is diagnostically important as it eliminates equivocal assessment of thyroid function and treatment especially where proper methodology for free t4 (ft4) estimation is not availa ... | 2004 | 15489553 |
| clinical analysis of thyroid cancer in adult patients exposed to ionizing radiation due to the chernobyl nuclear accident: 5-year comparative investigations based on the results of surgical treatment. | the aim of study was to compare clinical and pathologic findings of surgically removed thyroid tumors in adults with or without history of irradiation due to the chernobyl accident. from 1990 to 2003, 2363 adults with no evidence of radiation influence in their history (group a) have undergone operation for thyroid nodules. during the same period, 311 patients (born before 1969) with strict evidence of chernobyl irradiation also underwent operation (group b). both groups were similar in age, sex ... | 2004 | 15490064 |
| prognostic factors of maxillary sinus malignancies. | analysis of a series of tumors of the maxillary sinus show contradictory outcome data. the purpose of this article was to study the prognostic factors that may have implications for patient management. | 2004 | 15490570 |
| genotypic diversity of oral actinomyces naeslundii genospecies 1 and 2 in caries-active preschool children. | a total of 991 isolates of actinomyces naeslundii were obtained from sound approximal tooth sites in either caries-active (n = 35) or caries-free (n = 20) preschool children. from this group of isolates, 101 strains were chosen to study the genotypic diversity of a. naeslundii genospecies 1 (n = 30), catalase-positive (n = 30), and catalase-negative genospecies 2 (n = 41). polymerase chain reaction-restriction fragment length polymorphism (pcr-rflp), with a pair of primers targeting the 16s ribo ... | 2004 | 15491462 |
| local recurrence after radical cystectomy for invasive bladder cancer: an analysis of predictive factors. | to examine which clinicopathologic parameters predict clinically detectable local recurrence after radical cystectomy. local recurrence after radical cystectomy for invasive bladder cancer was infrequently observed until 20 years ago because of the lack of adequate diagnostic tools. the recent development and use of pelvic computed tomography has allowed us to detect local recurrence more precisely. however, only a few studies have investigated the rate and pattern of local recurrence in the com ... | 2004 | 15491713 |
| association of nucleophosmin/b23 mrna expression with clinical outcome in patients with bladder carcinoma. | to determine whether nucleophosmin/b23 mrna expression in bladder carcinoma predicts recurrence, progression, and survival. | 2004 | 15491744 |
| synthesis and properties of monodisperse oligofluorene-functionalized truxenes: highly fluorescent star-shaped architectures. | this paper describes the strategy toward novel monodisperse, well-defined, star-shaped oligofluorenes with a central truxene core and from monofluorene to quaterfluorene arms. introduction of solubilizing n-hexyl groups at both fluorene and truxene moieties results in highly soluble, intrinsically two-dimensional nanosized macromolecules t1-t4. the radius for the largest oligomer of ca. 3.9 nm represents one of the largest known star-shaped conjugated systems. cyclic voltammetry experiments reve ... | 2004 | 15493927 |
| analysis of gaa/ttc dna triplexes using nuclear magnetic resonance and electrospray ionization mass spectrometry. | the formation of a gaa/ttc dna triplex has been implicated in friedreich's ataxia. the destabilization of gaa/ttc dna triplexes either by ph or by binding to appropriate ligands was analyzed by nuclear magnetic resonance (nmr) and positive-ion electrospray mass spectrometry. the triplexes and duplexes were identified by changes in the nmr chemical shifts of h8, h1, h4, 15n7, and 15n4. the lowest ph at which the duplex is detectable depends upon the overall stability and the relative number of ho ... | 2004 | 15494127 |
| how an rna ligase discriminates rna versus dna damage. | t4 rna ligase 2 (rnl2) exemplifies a family of rna-joining enzymes that includes protozoan rna-editing ligases. rnl2 efficiently seals 3'-oh/5'-po4 rna nicks in either a duplex rna or an rna:dna hybrid but cannot seal dna nicks. rna specificity arises from a requirement for at least two ribonucleotides immediately flanking the 3'-oh of the nick; the rest of the nicked duplex can be replaced by dna. the terminal 2'-oh at the nick is important for the attack of the 3'-oh on the 5'-adenylated stran ... | 2004 | 15494308 |
| preoperative versus postoperative chemoradiotherapy for rectal cancer. | postoperative chemoradiotherapy is the recommended standard therapy for patients with locally advanced rectal cancer. in recent years, encouraging results with preoperative radiotherapy have been reported. we compared preoperative chemoradiotherapy with postoperative chemoradiotherapy for locally advanced rectal cancer. | 2004 | 15496622 |
| ["euthanasia"--victims and test subjects. the fate of diseased, disabled children in berlin during world war ii]. | this article shows, through a study of the berlin-brandenburg region, that children and juveniles who were subjected to the killings of diseased and disabled, or mentally retarded, persons during the third reich did not only fall victim to the operations of the "reichsausschuss" ("reich commission for registration of severe disorders in childhood"). many were also included in the gas chamber killings of the "t4"-action and in various decentralized killing actions. furthermore, the co-operation o ... | 2004 | 15497481 |
| electrographic imaging of recognition memory in 34-38 week gestation intrauterine growth restricted newborns. | electrophysiological imaging of recognition memory using event-related potentials (erps) in intrauterine growth-restricted (iugr) newborns allows assessment of recognition memory before the onset of multiple confounding variables. animal models that reproduce the physiologic components associated with iugr have demonstrated adverse effects on the hippocampus, a structure that is essential to normal memory processing. previous electrophysiologic studies have demonstrated shortened auditory-evoked ... | 2004 | 15498545 |
| d(g3t4g4) forms unusual dimeric g-quadruplex structure with the same general fold in the presence of k+, na+ or nh4+ ions. | we have recently communicated that dna oligonucleotide d(g(3)t(4)g(4)) forms a dimeric g-quadruplex in the presence of k(+) ions [j. am. chem. soc.2003, 125, 7866-7871]. the high-resolution nmr structure of d(g(3)t(4)g(4))(2) g-quadruplex exhibits g-quadruplex core consisting of three stacked g-quartets. the two overhanging g3 and g11 residues are located at the opposite sides of the end g-quartets and are not involved in g-quartet formation. d(g(3)t(4)g(4))(2) g-quadruplex represents the first ... | 2004 | 15498650 |
| bisphenol-a, an environmental contaminant that acts as a thyroid hormone receptor antagonist in vitro, increases serum thyroxine, and alters rc3/neurogranin expression in the developing rat brain. | considering the importance of thyroid hormone (th) in brain development, it is of potential concern that a wide variety of environmental chemicals can interfere with thyroid function or, perhaps of greater concern, with th action at its receptor (tr). recently bisphenol-a (bpa, 4,4' isopropylidenediphenol) was reported to bind to the rat tr and act as an antagonist in vitro. bpa is a high production volume chemical, with more than 800 million kg of bpa produced annually in the united states alon ... | 2005 | 15498886 |
| multivariate analysis on factors affecting suppression of thyroid-stimulating hormone in treated congenital hypothyroidism. | to determine the factors which influence the suppression of thyroid-stimulating hormone (tsh) in infants with congenital hypothyroidism (ch) following treatment. | 2004 | 15499223 |
| in utero and lactational exposure of long-evans rats to ammonium perchlorate (ap) disrupts ovarian follicle maturation. | ammonium perchlorate (ap) is a powerful oxidizer manufactured almost exclusively for the aerospace industry. ap salts are also used in airbags, flares, fertilizers, enamels and paints. as a result of widespread industrial use, ap has become a persistent environmental contaminant of drinking water in several u.s. states. ap ion disrupts the trapping of iodide as well as facilitates the discharge of unorganified iodide from the thyroid gland. such disturbances in thyroid hormone concentrations dur ... | 2004 | 15501380 |
| the role of an activating peptide in protease-mediated suicide of escherichia coli k12. | activation of latent proteinases ensures that the timing of proteolysis is regulated precisely, a process that generally involves proteolytic excision of a pro-region or a tightly bound inhibitor. here we define the activation mechanism for lit, a dormant suicide proteinase in escherichia coli k-12. previous work has shown that gol, a short sequence within the major capsid protein gp23, activates lit during the latter stages of t4 phage infection. this results in cell death and exclusion of the ... | 2005 | 15501819 |
| a prospective, randomized, double-blind comparison of unilateral spinal anesthesia with hyperbaric bupivacaine, ropivacaine, or levobupivacaine for inguinal herniorrhaphy. | in 60 patients undergoing inguinal hernia repair, we compared the clinical profile of unilateral spinal anesthesia produced with either 8 mg of hyperbaric bupivacaine 0.5% (n = 20), 8 mg of hyperbaric levobupivacaine 0.5% (n = 20), or 12 mg of hyperbaric ropivacaine 0.5% (n = 20). the study drug was injected slowly through a 25-gauge whitacre directional needle and patients maintained the lateral decubitus position for 15 min. the onset time and intraoperative efficacy were similar in the three ... | 2004 | 15502035 |
| 32p-postlabeling analysis of dna adducts. | 32p-postlabeling analysis is an ultrasensitive method for the detection of dna adducts, such as those formed directly by the covalent binding of carcinogens and mutagens to bases in dna, as well as other dna lesions resulting from modification of bases by endogenous or exogenous agents (e.g., oxidative damage). the procedure involves four main steps: enzymatic digestion of a dna sample; enrichment of the adducts; radiolabeling of the adducts by t4 kinase-catalyzed transference of 32p-orthophosph ... | 2005 | 15502206 |
| modification of the 32p-postlabeling method to detect a single adduct species as a single spot. | the original 32p-postlabeling method developed by randerath and his colleagues has been modified to detect a single type of adduct as a single spot in thin-layer chromatography (tlc), because some types of adducts gave multiple adduct spots by the original method. in the remodified methods, dna is first digested with micrococcal nuclease and phophodiesterase ii and then labeled with [gamma-32p]atp under standard or adduct-intensification conditions. since the labeled digest includes adducted mon ... | 2005 | 15502207 |
| three-dimensional structure of the r115e mutant of t4-bacteriophage 2'-deoxycytidylate deaminase. | 2'-deoxycytidylate deaminase (dcd) converts deoxycytidine 5'-monophosphate (dcmp) to deoxyuridine 5'-monophosphate and is a major supplier of the substrate for thymidylate synthase, an important enzyme in dna synthesis and a major target for cancer chemotherapy. wild-type dcd is allosterically regulated by the end products of its metabolic pathway, deoxycytidine 5'-triphosphate and deoxythymidine 5'-triphosphate, which act as an activator and an inhibitor, respectively. the first crystal structu ... | 2004 | 15504034 |
| the anti-thyroid drug methimazole induces neovascularization in the neonatal rat analogous to rop. | to determine the effect of methimazole (mmi), an anti-thyroid drug known to reduce serum l-thyroxine (t4), and insulin-like growth factor (igf)-1 concentrations, on retinal vascular development in neonatal rats. | 2004 | 15505068 |
| comparison of the effect of two different doses of 0.75% glucose-free ropivacaine for spinal anesthesia for lower limb and lower abdominal surgery. | we compared the clinical efficacy and safety of two doses of ropivacaine for spinal anesthesia in chinese patients undergoing lower limb and lower abdominal surgery. in this randomized, open-label study, 40 patients were divided into two groups: group a received 3.5 ml (26.25 mg) of 0.75% glucose-free ropivacaine, and group b received 4.5 ml (33.75 mg). sensory and motor blocks were assessed during and after surgery through to complete recovery. seven standard measurements were taken: time to on ... | 2004 | 15506554 |
| a high prevalence of consanguineous and severe congenital hypothyroidism in an iranian population. | to determine the incidence of permanent congenital hypothyroidism (ch) in tehran and damavand, cord blood spots were collected from february 1998-august 2002 and infants with tsh > or =20 mu/l were recalled. ch was confirmed in neonates (aged > or =7 days) with serum tsh >10 mu/l and t4 <84 nmol/l. cases were followed up until september 2003. dysgenesis was detected by thyroid imaging. in eutopic cases, serum tsh and t4 measurements following levothyroxine discontinuation (2-3 years of age) conf ... | 2004 | 15506679 |
| divergence of the mrna targets for the ssb proteins of bacteriophages t4 and rb69. | the single-strand binding (ssb) protein of phage t4 (t4 gp32, product of gene 32) is a mrna-specific autogenous translational repressor, in addition to being a sequence-independent ssdna-binding protein that participates in phage dna replication, repair and recombination. it is not clear how this physiologically essential protein distinguishes between specific rna and nonspecific nucleic acid targets. here, we present phylogenetic evidence suggesting that ssdna and specific rna bind the same gp3 ... | 2004 | 15507125 |
| [assessment of the usefulness of the presence of antithyroid peroxidase antibodies (tpoab) in patients with end-stage renal failure treated with hemodialysis]. | due to a high frequency of autoimmune diseases in patients with esrf we observed for 4 years 8 patients treated with hd with high level of tpoab and 8 patients without tpoab. aim of the study was to estimate the role of tpoab as a prognostic factor of hypothyreosis. we observed in a 4-years follow-up significant increase of tsh (p<0.05) in patients with high tpoab level. ft3 and ft4 did't change in this time. in the group without tpoab we observed significant (p<0.01) decrease of ft3 probably du ... | 2004 | 15508791 |
| lip cancer experience in mexico. an 11-year retrospective study. | lip cancer is the most frequent malignant neoplasm of the oral cavity; however, there is no information available on the incidence of this type of cancer in mexico. this study provides information about the clinico-pathological features of lip cancer patients admitted at a cancer hospital in mexico city during an 11-year period and describes the treatment modalities performed and their results. a total of 113 patients were studied. there were 74 men (65.5%) and 39 women (34.5%), ranging in age f ... | 2004 | 15509490 |
| effect of duration of cold stress on plasma adrenal and thyroid hormone levels and immune responses in chicken lines divergently selected for antibody responses. | there is increasing evidence that stress affects various immune processes. some of these changes are due to hormonal changes involving corticosterone (cort), triiodothyronine (t3), and thyroxine (t4). effects of stress depend on the nature of specific stressors (e.g., thermal extremes, diet, pollutants), and stress-modifiers (e.g., genetic make-up, duration and severity of the stressors). we studied the effects of a specific stress (cold stress) with stress-modifiers (duration of stress and geno ... | 2004 | 15510547 |
| feasibility and results of awake thoracoscopic resection of solitary pulmonary nodules. | general anesthesia with single-lung ventilation is considered mandatory for thoracoscopic pulmonary resection. we assessed in a randomized study the feasibility and results of awake thoracoscopic resection of solitary pulmonary nodules. | 2004 | 15511470 |
| serum concentrations of iodine, thyroxine (t4), triiodothyronine (t3), thyrotropin (tsh) and insulin-like growth factor 1 (igf-1) during the last trimester of pregnancy, during labour, and in early puerperium of women with normal pregnancy or with intrauterine growth retardation (iugr). | in women with intrauterine growth retardation (iugr), insulin-like growth factor 1 (igf-1) concentrations tended to reduce during the last trimester of pregnancy. parameters of thyroid function in maternal serum were not distinctly influenced by iugr, except for high concentrations of iodine. triiodothyronine (t3) concentrations in cord blood of normal pregnancies was significantly lower than maternal concentrations, but was relatively high when the fetus was growth retarded. the results are dis ... | 1997 | 15511878 |
| fatal intra-alveolar hemorrhage after rituximab in a patient with non-hodgkin lymphoma. | a 65-year-old male developed progressive dry cough and digital clubbing after starting rituximab-chop chemotherapy for non-hodgkin lymphoma. a lung biopsy showed loose non-necrotic granulomas in a background of mild fibrosis and rare eosinophils, compatible with a drug-induced hypersensitivity pneumonia. associated manifestations of this hypersensitivity reaction were a high eosinophil count, elevated serum levels of immunoglobulin e, and a skin rash consistent with pigmented purpuric dermatitis ... | 2004 | 15512824 |
| the genome of bacteriophage t4: an archeological dig. | | 2004 | 15514035 |
| quantitative trait loci associated with elevated thyroid-stimulating hormone in the wistar-kyoto rat. | thyroid hormones are essential for the regulation of developmental and physiological processes. the genetic factors underlying naturally occurring variability in mammalian thyroid function are, however, only partially understood. genetic control of thyroid function can be studied with animal models such as the inbred wistar-kyoto (wky) rat strain. previous studies established that wky rats have elevated tsh, slightly elevated total t3, and normal total t4 levels compared with wistar controls. th ... | 2005 | 15514085 |
| impact of ulceration in stages i to iii cutaneous melanoma as staged by the american joint committee on cancer staging system: an analysis of the german central malignant melanoma registry. | in 2001, the new american joint committee on cancer classification of cutaneous melanoma (cm) introduced ulceration of the primary melanoma as a new key parameter being represented in respective subcategories of the tumor (t) classification. the present study was performed to validate the prognostic significance of ulceration in relation to t thickness and clinical stages of cm (stages i to iii). | 2004 | 15514379 |
| efficacy and safety of transdermal methimazole in the treatment of cats with hyperthyroidism. | the objective of this study was to determine whether transdermal methimazole was as safe and effective as oral methimazole for the control of hyperthyroidism in cats. forty-seven cats with newly diagnosed hyperthyroidism were randomized to receive either transdermal methimazole in pluronic lecithin organogel (plo; applied to the inner pinna), or oral methimazole (2.5 mg q12h for either route). cats were evaluated at weeks 0, 2, and 4 with a physical exam, body weight determination, cbc, biochemi ... | 2004 | 15515580 |