| 5'-deiodinase type 1 activity in liver and brain of the thyroxine-treated dystrophic hamster. | dystrophic hamsters (dh), as well as dystrophic patients, exhibit alveolar hypoventilation (ah) and low plasma thyroid hormone levels. thyroxine (t4) treatment of young dh retards ah development, and improves respiratory function and contractility of skeletal muscles. however, the mechanism responsible for the hypothyroidism in dh is not known. one possible cause of the hypothyroidism is reduced activity of the 5'-deiodinase enzyme system, which converts t4 to the more active triiodothyronine (t ... | 2004 | 15231042 |
| impact of thyroid hormone deficiency on the developing cns: cerebellar glial and neuronal protein expression in rat neonates exposed to antithyroid drug propylthiouracil. | the developing rat cerebellum is vulnerable to thyroid hormone (th) deficiency. the present study addresses the molecular mechanisms involved in this response. specifically, the study focuses on the expression of selected cerebellar proteins that are known to be directly [protein expressing 3-fucosyl-n-acetyl-lactosamine antigen (cd15), neuronal cell adhesion molecule (l1)] or indirectly [glial fibrillary acidic protein (gfap)], involved in glial-neuronal interactions and thus regulation of cell ... | 2004 | 15233577 |
| high-dose-rate interstitial brachytherapy for oropharyngeal carcinoma: results of 83 lesions in 82 patients. | low-dose-rate interstitial brachytherapy (ldrib) represents an effective modality for treatment of oropharyngeal carcinoma. the drawback is radioexposure of medical personnel. to eliminate this concern, we initiated high-dose-rate interstitial brachytherapy (hdrib) in 1993. the present study evaluated the efficacy and complications associated with this approach. | 2004 | 15234031 |
| imrt for postoperative treatment of gastric cancer: covering large target volumes in the upper abdomen: a comparison of a step-and-shoot and an arc therapy approach. | data from the randomized intergroup trial 116 suggest effectiveness of adjuvant radiochemotherapy in patients with advanced gastric cancer. late toxicity, however, especially with respect to the kidneys, may pose significant longtime problems. intensity-modulated radiotherapy (imrt) may reduce toxicity to organs at risk. to evaluate the relative merits of different imrt approaches, we performed a plan comparison between a step-and-shoot class solution and an ap-pa setup, a conventional box techn ... | 2004 | 15234061 |
| quality specifications in thyroid diseases. | laboratory tests to support the diagnosis and management of thyroid diseases have undergone significant changes with the introduction of highly sensitive assays for thyroid stimulating hormone (tsh) and free t4 and t3 concentrations in plasma. given the importance of these measurements, quality specifications are needed to ensure accurate results. goals for precision and accuracy are available based on known intraindividual and interindividual biological variation. | 2004 | 15234638 |
| role for postoperative radiation therapy in adenoid cystic carcinoma of the head and neck. | clarify the role for postoperative radiation for adenoid cystic carcinoma (acc) of the head and neck as it relates to tumor site, t-stage, and surgical margin status. | 2004 | 15235347 |
| [potentializing of tricyclics and serotoninergics by thyroid hormones in resistant depressive disorders]. | in response to the increase of resistant depressive disorders and in spite of improved treatments, numerous studies were conducted in the last thirty years aiming at assessing the pre-morbid thyroid state of depressed patients resistant to well conducted tricyclic treatments. "minimal" thyroid abnormalities were evidenced as well as central thyroid disorders which may not be detected by peripheral-i.e plasmatic- dosages. regarding the premorbid thyroid status, the hypothesis of subclinical hypot ... | 2004 | 15235525 |
| thyroid hormone-dependent seasonality in american tree sparrows (spizella arborea): effects of gc-1, a thyroid receptor beta-selective agonist, and of iopanoic acid, a deiodinase inhibitor. | to explore the role of th in the control of seasonality [i.e., photoperiodic testicular growth, photorefractoriness, and postnuptial (prebasic) molt] in american tree sparrows (spizella arborea), we performed experiments in which thx males were simultaneously photostimulated and given th replacement therapy. in the first experiment, equimolar concentrations (1x = 1.3 nmol) of t4, t3, or gc-1, an iodine-free trbeta agonist, were administered s.c. daily during the first 21 days of photostimulation ... | 2004 | 15235810 |
| spinal anesthesia with pentazocine for total abdominal hysterectomy. | intraspinal pentazocine, 1.5 mg/kg, produced sufficient analgesia and moter block in 50 cases of abdominal total hysterectomy. pentazocine, a derivative of benzomorphans, shares some common characteristics with local anesthetics in the chemical structure. both agents have an aromatic ring and an intermediate chain, in common, which connects the former to nitrogen moiety, and the local anesthetic action was anticipated. the onset of the sensory block was 3.2 +/- 0.9 (mean +/- sd) min, and the max ... | 1988 | 15235841 |
| the degree of muscle relaxation requested by the surgens during upper abdominal surgery. | the degree of muscle relaxation required for the abdominal surgery should differ at different phase of operation. to test this hypothesis muscle relaxation was assessed subjectively by the surgeon and the results were compared with quantitative observations of the degree of response depression to train of four (t4) stimulation at various stages of surgery. maximum relaxation, with a t4 ratio of less than 10%, was required immediately after the skin incision and during closure of the abdominal wa ... | 1990 | 15235981 |
| sympathetic skin response in patients with spinal cord injury. | to assess the effectiveness of sympathetic skin response in evaluating peripheral sympathetic nerve activity of patients with spinal cord injury, and to report on the basic properties of sympathetic skin response. | 2004 | 15237120 |
| prevalence of congenital hypothyroidism in isfahan, iran: results of a survey on 20,000 neonates. | to evaluate the prevalence of congenital hypothyroidism (ch) in a screening program performed for the first time in isfahan, iran. | 2004 | 15237248 |
| lipid abnormalities in children with types a and b niemann pick disease. | to characterize the lipid profiles in patients with types a and b niemann pick disease (npd) and determine if lipid abnormalities are associated with evidence of early cardiovascular disease or correlate with genotype. | 2004 | 15238911 |
| thyroid hormone indices during illness in six hypothyroid subjects rendered euthyroid with levothyroxine therapy. | we wanted to evaluate changes in the natural course of serum thyroxine (t4), tri-iodothyronine (t3), reverse tri-iodothyronine (rt3), and thyroid stimulating hormone (tsh) concentrations during hospitalization for an acute illness, in subjects rendered euthyroid with levothyroxine (lt4) replacement therapy. | 2004 | 15239022 |
| thyroid autoantibodies in autoimmune diseases. | abnormalities in the thyroid function and thyroid autoantibodies have been frequently described in patients with autoimmune diseases but seldom in antiphospholipid syndrome patients. in order to determine the prevalence of thyroid function and autoimmune abnormalities, we compared serum thyrotropin (tsh, serum free thyroxine (t4) levels, thyroid antithyroglobulin (tgab) and antithyroperoxidase (tpoab) levels of 25 patients with systemic sclerosis, 25 patients with rheumatoid arthritis and 13 pat ... | 2004 | 15239536 |
| clinical characteristics of familial adenomatous polyposis and management of duodenal adenomas. | the aim of this study was to evaluate the clinical characteristics of patients with familial adenomatous polyposis (fap) undergoing surgical treatment over a 10-year period and specifically to evaluate the incidence and clinical outcome of patients treated for duodenal adenomas. patients with fap who underwent surgical treatment for colonic polyposis at the university of louisville from january 1992 to july 2002 were investigated. surgical treatment included colectomy and ileal j-pouch-anal anas ... | 2004 | 15239991 |
| effect of cold exposure on serum dbh and interscapular brown adipose tissue mao activity in hypothyroid t3- and t4-treated rats. | as the indicators of sympathetic nervous system (sns) function, the activity of serum dopamine-beta-hydroxylase (dbh) and interscapular brown adipose tissue (ibat) monoamine oxidase (mao) were examined in rats that were chemically thyroidectomized (tx), treated with thyroid hormones, and exposed to cold (4 degrees c). in tx animals, body temperature (bt) significantly decreased, and relative ibat mass increased as compared with control, euthyroid animals, independent of the ambient temperature. ... | 2004 | 15240371 |
| placing single-molecule t4 lysozyme enzymes on a bacterial cell surface: toward probing single-molecule enzymatic reaction in living cells. | the t4 lysozyme enzymatic hydrolyzation reaction of bacterial cell walls is an important biological process, and single-molecule enzymatic reaction dynamics have been studied under physiological condition using purified escherichia coli cell walls as substrates. here, we report progress toward characterizing the t4 lysozyme enzymatic reaction on a living bacterial cell wall using a combined single-molecule placement and spectroscopy. placing a dye-labeled single t4 lysozyme molecule on a targete ... | 2004 | 15240499 |
| serum osteocalcin levels in hyperthyroidism before and after antithyroid therapy. | hyperthyroidism is characterized by accelerated bone turnover, caused from direct stimulation of bone cells by increased thyroid hormones. in this study, we aimed to investigate serum osteocalcin levels as a bone formation marker, before antithyroid (propylthiouracil) therapy at hyperthyroid stage and after antithyroid therapy at euthyroid stage of the patients. twenty four hyperthyroid patients (18 females, 6 males) and 20 (13 females, 7 males) healthy controls were included into this study. bl ... | 2004 | 15240927 |
| the reproducibility of perceptually regulated exercise responses during short-term cycle ergometry. | the purpose of this study was to assess the reproducibility over four trials of perceptually regulated exercise intensity during short-term cycle ergometry. recent research has suggested that an improvement in the reproducibility (better agreement) of the exercise output would be observed with a repeated practice using regulatory tools such as borg's 6 - 20 rating of perceived exertion (rpe) scale. eighteen healthy active volunteers (nine males, mean age (+/- sd) 24.7 +/- 3.4 yr, and nine female ... | 2004 | 15241716 |
| [contribution of serum cyfra 21-1 in nasopharyngeal carcinoma in tunisia]. | cyfra 21-1 is a recognised marker for epidermoid lung and head and neck carcinomas oriented to the cytokeratin 19 that is expressed particularly in malignant epithelial cells. the aims of this study were to evaluate the importance of the use of this marker in nasopharyngeal carcinoma (npc). our prospective study interested 41 patients (33m/8f) with a mean age of 44 years (13 to 70) with 8 of them aged less than 30 years, presenting a nasopharyngeal carcinoma histologically confirmed from septemb ... | 2004 | 15242321 |
| impact of adjuvant systemic chemotherapy on postoperative survival in patients with high-risk urothelial cancer. | the objective of this study was to retrospectively investigate the effectiveness of adjuvant combination chemotherapy for locally advanced urothelial cancer. | 2004 | 15242352 |
| relation between helicobacter pylori infection, thyroid hormone levels and cardiovascular risk factors on blood donors. | the aim of this study was to assess the relationship between helicobacter pylori (hp) infection, serum thyroid hormone levels and certain cardiovascular risk factors in normal volunteers. in 110 blood donors (85 men, 25 women, aged 35.6 +/- 9.76) the serum levels of igg antibodies against hp were estimated using a sensitive immunoassay. serum estimation of t3, t4, tsh, ft3, ft4, thyroid (microsomial) autoantibodies, c-reactive-protein, a1-acid-glycoprotein, vitamin b12, folic acid, cholesterol, ... | 2003 | 15244214 |
| reactive oxygen species production by blood neutrophils of patients with laryngeal carcinoma and antioxidative enzyme activity in their blood. | squamous cell carcinoma of the head and neck is a devastating illness with a severe impact on affected individuals. several mechanisms may lead to oxidative stress in tumor-bearing patients, among others chronic inflammation. inflammatory cells, especially macrophages and neutrophil leukocytes, may produce reactive oxygen species (ros) which participate in carcinogenesis and tumor-associated immunosuppression. the aim of the study presented in this paper was to compare the production of reactive ... | 2004 | 15244248 |
| dimensional complexity of the eeg in patients with posttraumatic stress disorder. | recent electrophysiological studies have reported evidence of information processing abnormalities in patients with posttraumatic stress disorder (ptsd). the aim of this study is to examine dynamical complexity of the eeg in ptsd patients, which is thought to reflect information processing of the brain. resting eeg recordings (32,800 data points acquired continuously from 82 s of an eeg record) were obtained in 16 channels of 27 patients with ptsd from a mixed civilian trauma population and 14 h ... | 2004 | 15246457 |
| [severe neonatal hyperthyroidism which reveals a maternal graves' disease]. | two of every thousand pregnancies are complicated by graves' disease. diagnosis is suggested by maternal disorders (tachycardia, exophthalmia, weight loss.) or fetal disorders (tachycardia, intra-uterine growth retardation, preterm birth.). due to transfer into the fetal compartment of maternal antibodies which stimulate the fetal thyroid by binding to the thyroid thyrotropin (tsh) receptor, only 1% of children born to these mothers are described as having hyperthyroidism. neonatal thyrotoxicosi ... | 2004 | 15247872 |
| hypothyroidism as a risk factor for cardiovascular disease. | the cardiovascular risk in patients with hypothyroidism is related to an increased risk of functional cardiovascular abnormalities and to an increased risk of atherosclerosis. the pattern of cardiovascular abnormalities is similar in subclinical and overt hypothyroidism, suggesting that a lesser degree of thyroid hormone deficiency may also affect the cardiovascular system. hypothyroid patients, even those with subclinical hypothyroidism, have impaired endothelial function, normal/depressed syst ... | 2004 | 15249698 |
| management of thyroxine therapy during pregnancy. | to review the management of thyroxine (t4) therapy in pregnant patients with hypothyroidism. | 1996 | 15251531 |
| nonthyroidal illness syndrome or euthyroid sick syndrome? | to characterize the nonthyroidal illness syndrome (ntis) and to discuss various underlying potential biochemical mechanisms for this condition. | 1996 | 15251561 |
| familial dysalbuminemic hyperthyroxinemia: cumulative experience in 29 consecutive patients. | the syndrome of familial dysalbuminemic hyperthyroxinemia (fdh), an inherited abnormality characterized by the presence of a variant serum albumin with preferential affinity for t4, is recognized with increasing frequency as a cause of elevated total and free t4 serum values in clinically euthyroid patients with normal tsh levels. hyperthyroxinemia caused by this syndrome is occasionally confused with hyperthyroidism or thyroid hormone resistance syndromes, which may prompt unnecessary treatment ... | 1995 | 15251607 |
| effect of desuppression on nodular thyroid disease. | to ascertain the clinical effect of discontinuation of thyroxine (t4) suppression therapy in patients with solitary thyroid nodules or multinodular goiters (mngs). | 1997 | 15251794 |
| intramolecular nucleophilic activation promoting efficient hydrolytic cleavage of dna by (aqua)bis(dipyridoquinoxaline)copper(ii) complex. | the axial aqua bound copper(ii) complex [cu(dpq)2(h2o)](clo4)2, having a planar nn-donor heterocyclic base dipyridoquinoxaline (dpq) as the dna minor groove binder, shows efficient hydrolytic cleavage of supercoiled dna in the dark and in the absence of any external reagents, as evidenced from t4 ligase experiments, with a rate of 5.58 +/- 0.4 h(-1) and a rate enhancement of 1.55 x 10(8). | 2004 | 15252488 |
| effects of vinclozolin on spermatogenesis and reproductive success in the japanese quail (coturnix coturnix japonica). | in a one-generation reproduction study, the major agricultural fungicide vinclozolin was administered to adult japanese quail for a period of 6 weeks at dietary levels of 125 and 500 ppm. fertility and reproductive performance were not affected up to the highest concentration, although the examination of additional endpoints in the drakes (spermatid count, histology of the testis) provided some evidence of an inhibition of spermatogenesis at both dietary concentrations. likewise, there were no i ... | 2004 | 15253051 |
| evaluation of breast sensibility using dermatomal somatosensory evoked potentials. | this study was undertaken to prospectively evaluate breast sensibility before and after reduction mammaplasty with a new, objective, and quantitative neurophysiologic method based on the anatomic knowledge of breast innervation and the congruent areas of dermatomal maps. an innovative application of dermatomal somatosensory evoked potentials was used to study the breast regions of 42 healthy women, bilaterally. the areas stimulated in each breast were the superior quadrant, the nipple-areola com ... | 2004 | 15253186 |
| correlation of autonomic indices with thyroid status. | the autonomic status in female thyroid patients was compared with healthy, age matched normal females taken as controls. the patients (29 +/- 7 years) were categorised into two groups: hyperthyroid and hypothyroid. the valsalva manoeuvre, standing to lying ratio (s/l ratio) and immediate heart rate response to standing (30:15 ratio) to assess the parasympathetic status while the galvanic skin response (gsr) was recorded to assess the sympathetic status. statistical analysis was done using studen ... | 2003 | 15255619 |
| [thyrotropin-secreting pituitary adenoma:a clinicopathological analysis of seven cases]. | to study the clinicopathological features of thyrotropin-secreting pituitary adenoma (tsh adenoma). | 2004 | 15256109 |
| [a rare hyperthyroid syndrome]. | the exophthalmos, myxedema, acropachy (ema) syndrome is a rare extrathyroid syndrome, interesting about 1% of the patients affected by extrathyroid complications of graves' disease. the ratio female/male is 3.4:1 and this case report is very rare. the patient, a 52-year-old man, presented a serious ophthalmopathy with pretibial myxedema, acropachy with joint pain. the triad manifested itself after some ophthalmopathy treatments, i.e. total thyroidectomy, steroidal retrobulbar therapy and radioth ... | 2004 | 15257258 |
| t4 asia blocks dna recognition by remodeling sigma70 region 4. | bacteriophage t4 asia is a versatile transcription factor capable of inhibiting host gene expression as an 'anti-sigma' factor while simultaneously promoting gene-specific expression of t4 middle genes in conjunction with t4 mota. to accomplish this task, asia engages conserved region 4 of eschericia coli sigma70, blocking recognition of most host promoters by sequestering the dna-binding surface at the asia/sigma70 interface. the three-dimensional structure of an asia/region 4 complex reveals t ... | 2004 | 15257291 |
| thyroid dysfunction and cardiological management in patients receiving amiodarone. | to determine the prevalence of thyroid dysfunction in patients receiving amiodarone, and the possible associated factors. the study also aimed at assessing the effect of amiodarone on thyroid function through the application of a questionnaire to cardiologists. | 2004 | 15257370 |
| [the interesting case -- case number 61]. | a 58-year-old patient presented after having undergone radiation therapy, afterloading therapy and chemotherapy of a t4 nasopharynx carcinoma. on the basis of the mri findings, local tumour recurrence was suspected. the samples taken from the nasopharynx and the left maxillary sinus confirmed this diagnosis. neuroradiological imaging showed that the tumour extended into the area around the left skull base and also revealed an irregular formation located in the left temporal flap. therefore not o ... | 2004 | 15257498 |
| high-throughput protein structural analysis using site-directed fluorescence labeling and the bimane derivative (2-pyridyl)dithiobimane. | we present a site-directed fluorescence labeling (sdfl) study of 25 different t4 lysozyme protein samples labeled with the thiol-cleavable fluorophore, (2-pyridyl)dithiobimane (pdt-bimane). our results demonstrate pdt-bimane can be used in cysteine-scanning studies to detect protein secondary structure, and to map proximity between sites in proteins by monitoring tryptophan quenching of bimane fluorescence. in addition, the reducible nature of pdt-bimane can be exploited to resolve problems ofte ... | 2004 | 15260485 |
| mucoepidermoid carcinoma of the parotid gland: the mayo clinic experience. | to determine clinical and histopathologic features of mucoepidermoid carcinoma of the parotid gland, specifically, the relation of tumor stage and grade and treatment type with clinical outcome. | 2004 | 15262762 |
| protein-dna footprinting by endcapped duplex oligodeoxyribonucleotides. | oligodeoxyribonucleotides (5'-phosphorylated) of varying lengths were capped using a polyamide linker to form thermodynamically stable, endcapped dna duplexes containing 8-14 bp. we have employed these endcapped dna duplexes as tools to determine the dna footprint of t4 dna ligase. by high-performance liquid chromatography and page analysis of the ligation mixtures of the endcapped dna duplexes, we have found that by varying the lengths and the position of the nick, we can determine the minimal ... | 2004 | 15263063 |
| patterns and predictors of sleep pattern disturbance after cardiac surgery. | the purposes of this study were to examine changes in sleep patterns after cardiac surgery and the contributions of preoperative sleep to postoperative sleep. seventy-two cardiac surgery patients wore wrist actigraphs for 3 days during the preoperative period (t1) and the 1st (t2), 4th (t3), and 8th (t4) postoperative weeks. they completed the pittsburgh sleep quality index at t1, t3, and t4. sleep was most disturbed during the 1st postoperative week and improved at t3 and t4. overall, sleep pat ... | 2004 | 15264261 |
| chemical conjugation of heterologous proteins on the surface of cowpea mosaic virus. | genetic economy leads to symmetric distributions of chemically identical subunits in icosaherdal and helical viruses. modification of the subunit genes of a variety of viruses has permitted the display of polypeptides on both the infectious virions and virus particles made in expression systems. icosahedral chimeric particles of this type often display novel properties resulting in high local concentrations of the insert. here we report an extension of this concept in which entire proteins were ... | 2004 | 15264868 |
| the functional domains of bacteriophage t4 terminase. | the packaging of double-stranded genomic dna into some viral and all bacteriophage capsids is driven by powerful molecular motors. in bacteriophage t4, the motor consists of the portal protein assembly composed of twelve copies of gene product 20 (gp20, 61 kda) and an oligomeric terminase complex composed of gp16 (18 kda) and gp17 (70 kda). the packaging motor drives the 171-kbp t4 dna into the capsid utilizing the free energy of atp hydrolysis. evidence suggests that gp17 is the key component o ... | 2004 | 15265872 |
| thyroid hormone supplementation for the prevention of morbidity and mortality in infants undergoing cardiac surgery. | paediatric studies have demonstrated that cardiopulmonary bypass is associated with a decline in thyroid hormone levels. adult patients who undergo open heart surgery and receive triiodothyronine supplementation have demonstrated a dose-dependent increase in cardiac output which has been associated with an improved clinical outcome. thyroid hormone supplementation in infants may also reduce post-operative morbidity and mortality. | 2004 | 15266523 |
| the concentration of thyroid hormones and activities of iodothyronine deiodinases are altered in human brain gliomas. | we have determined the cellular concentration of thyroxine (t4) and triiodothyronine (t3) and the activities of two brain iodothyronine deiodinases, type ii (5'-d2) and type iii (5-d3), in two types of tissues --tumour (26) and non-tumour (5), derived either from human gliomas with various histological malignancies or from non-tumoural surrounding brain tissue. as it has been established, all patients before the surgery had the non-thyroidal illness syndrome (ntis). the concentration of serum t3 ... | 2004 | 15266780 |
| intermediate state representation approach to physical properties of electronically excited molecules. | propagator methods provide a direct approach to energies and transition moments for (generalized) electronic excitations from the ground state, but they do not usually allow one to determine excited state wave functions and properties. using a specific intermediate state representation (isr) concept, we here show how this restriction can be overcome in the case of the algebraic-diagrammatic construction (adc) propagator approach. in the isr reformulation of the theory the basic adc secular matri ... | 2004 | 15268179 |
| w3 theory: robust computational thermochemistry in the kj/mol accuracy range. | we are proposing a new computational thermochemistry protocol denoted w3 theory, as a successor to w1 and w2 theory proposed earlier [martin and de oliveira, j. chem. phys. 111, 1843 (1999)]. the new method is both more accurate overall (error statistics for total atomization energies approximately cut in half) and more robust (particularly towards systems exhibiting significant nondynamical correlation) than w2 theory. the cardinal improvement rests in an approximate account for post-ccsd(t) co ... | 2004 | 15268579 |
| paraplegia after delayed detection of inadvertent spinal cord injury during thoracic epidural catheterization in an anesthetized elderly patient. | we report a case of permanent paraplegia in an 81-yr-old patient who had thoracic epidural catheterization performed under general anesthesia for abdominal surgery. the epidural needle was introduced at the t9-10 interspace, and 3 passes were made to locate the epidural space with the loss-of-resistance-to-air technique. during the postoperative epidural pump infusion, the patient was unaware of the progressive motor and sensory impairment. sensory loss below t11 and paraplegia with no movement ... | 2004 | 15271743 |
| acanthamoeba induces cell-cycle arrest in host cells. | acanthamoeba can cause fatal granulomatous amoebic encephalitis (gae) and eye keratitis. however, the pathogenesis and pathophysiology of these emerging diseases remain unclear. in this study, the effects of acanthamoeba on the host cell cycle using human brain microvascular endothelial cells (hbmec) and human corneal epithelial cells (hcec) were determined. two isolates of acanthamoeba belonging to the t1 genotype (gae isolate) and t4 genotype (keratitis isolate) were used, which showed severe ... | 2004 | 15272056 |
| role of ulnar forearm free flap in oromandibular reconstruction. | the ulnar forearm flap is not frequently utilized for oromandibular reconstruction. this study evaluated the usefulness of the ulnar free flap for reconstruction. a retrospective study of 32 patients was conducted. the ulnar forearm flap was combined with an osseous flap in 24 patients. nine females and 23 males with a mean age of 58.15 years comprised our study population. squamous-cell carcinoma was the diagnosis in 93.75% of cases (56.25% t4), of which 20% were recurrent. functional evaluatio ... | 2004 | 15274184 |
| concurrent chemoradiotherapy in locoregionally recurrent nasopharyngeal carcinoma. | to analyze the results of concurrent chemoradiotherapy in patients with locoregional recurrent nasopharyngeal carcinoma. | 2004 | 15275714 |
| is surgery for t4 non-small-cell lung cancer worthwhile? | | 2004 | 15276574 |
| bone mineral density in women receiving thyroxine suppressive therapy for differentiated thyroid carcinoma. | most patients with well-differentiated thyroid carcinoma have an excellent prognosis and are likely to live long enough to be subjected to osteoporosis. the purpose of this study was to investigate the consequences of treatment with a supraphysiological dose of levothyroxine (l-t4) on bone mineral density (bmd) in taiwanese women with differentiated thyroid cancer. | 2004 | 15278189 |
| pharmacokinetics and pharmacodynamics of vecuronium bromide. | the pharmacokinetics and pharmacodynamics of vecuronium bromide were studied in patients under general anesthesia of enflurane and nitrous oxide in oxygen. eighteen patients were randomly divided into two groups which received either 0.05 mg.kg(-1) (low dose group) or 0.20 mg.kg(-1) (high dose group) of vecuronium intravenously. the plasma concentration of vecuronium was determined by high performance liquid chromatography. the neuromuscular blocking effect was assessed by measuring the twitch t ... | 1992 | 15278580 |
| normal pregnancy in a woman with nesidioblastosis treated with somatostatin analog octreotide. | we report the case of a 36-yr-old woman with nesidioblastosis treated throughout pregnancy with high doses of octreotide. we studied the course of blood glucose, foetal growth and development. | 2004 | 15279081 |
| primary congenital hypothyroidism: clinical characteristics and etiological study. | forty-eight children with primary congenital hypothyroidism, who attended chiang mai university hospital, during 1977-2000, were reviewed. the female to male ratio was 2:1. the age at diagnosis ranged from 1 month to 12 years 4 months, with 27% of the cases diagnosed within the first three months of life, 37.5% within the first year, and 62.5% after one year of age. constipation, delayed development and growth, feeding problems, prolonged neonatal jaundice and goiter were more common. prolonged ... | 2004 | 15279337 |
| a phase ii multicenter clinical trial of systemic bexarotene in psoriasis. | bexarotene, a novel and unique synthetic p, rxr-selective retinoid, is available as a treatment for cutaneous t-cell lymphoma. in psoriasis, a common retinoid-sensitive disease, no data are available on bexarotene treatment. | 2004 | 15280844 |
| thrombotic complications of implanted central venous access devices: prospective evaluation. | implanted venous access devices (ivad) are routinely used in oncologic patients. thrombotic complication is a source of morbidity. during one year 246 patients with different solid neoplastic diseases received ivad for chemotherapy administration. two hundred forty-nine ivad were placed percutaneously or by surgical cutdown. ivad were flushed immediately after implantation with 3-5 ml of heparinized saline (100 u/ml). no monthly flush was required. a prospective evaluation of thrombotic complica ... | 2004 | 15281282 |
| esophageal cancer: outcomes of surgery, neoadjuvant chemotherapy, and three-dimension conformal radiotherapy. | neoadjuvant chemotherapy and radiation are being utilized with increasing frequency in the multimodal treatment of esophageal cancer, although their effects on morbidity, mortality, and survival remain unclear. the objective of this study was to determine the outcome of multimodal treatment in patients with localized esophageal cancer treated at a single institution. between 1995 and 2002, 118 patients underwent treatment for localized esophageal cancer, utilizing surgery alone, chemoradiation a ... | 2004 | 15282698 |
| treatment of "locally advanced" well-differentiated thyroid carcinomas. | to analyse thyroid carcinomas having an extrathyroid extension in order to identify the principal prognostic factors and outline an effective therapeutic strategy. | 2004 | 15283382 |
| [functional outcomes and quality of life in patients with anterior resection for rectal cancer. does preoperative manometry predict the feasibility of a j-pouch?]. | the goal in the treatment of rectal cancer is the recovery of the disease with the best fecal continence and quality of life. the authors compared quality of life and manometric results in patients treated with neo-adjuvant chemotherapy and rectal low anterior resection (lra). | 2004 | 15283400 |
| c-fos expression in rat brain stem and spinal cord in response to activation of cardiac ischemia-sensitive afferent neurons and electrostimulatory modulation. | the purpose of this study was to identify central neuronal sites activated by stimulation of cardiac ischemia-sensitive afferent neurons and determine whether electrical stimulation of left vagal afferent fibers modified the pattern of neuronal activation. fos-like immunoreactivity (fos-li) was used as an index of neuronal activation in selected levels of cervical and thoracic spinal cord and brain stem. adult sprague-dawley rats were anesthetized with urethane and underwent intrapericardial inf ... | 2004 | 15284072 |
| the epstein-barr virus polymerase accessory factor bmrf1 adopts a ring-shaped structure as visualized by electron microscopy. | epstein-barr virus (ebv) encodes a set of core replication factors used during lytic infection in human cells that parallels the factors used in many other systems. these include a dna polymerase and its accessory factor, a helicase/primase, and a single strand binding protein. the ebv polymerase accessory factor has been identified as the product of the bmrf1 gene and has been shown by functional assays to increase the activity and processivity of the polymerase. unlike other members of this cl ... | 2004 | 15286084 |
| positive association of the dio2 (deiodinase type 2) gene with mental retardation in the iodine-deficient areas of china. | iodine deficiency is the commonest cause of preventable mental retardation (mr) worldwide. however, in iodine-deficient areas not everyone is affected and familial aggregation is common. this suggests that genetic factors may also contribute. thyroid hormone (th) plays an important role in fetal and early postnatal brain development. the pro-hormone t4 (3,3',5,5'-triiodothyronine) is converted in the brain to its active form, t3, or its inactive metabolite, reverse t3, mainly by the action of de ... | 2004 | 15286152 |
| use of sequence duplication to engineer a ligand-triggered, long-distance molecular switch in t4 lysozyme. | we have designed a molecular switch in a t4 lysozyme construct that controls a large-scale translation of a duplicated helix. as shown by crystal structures of the construct with the switch on and off, the conformational change is triggered by the binding of a ligand (guanidinium ion) to a site that in the wild-type protein was occupied by the guanidino head group of an arg. in the design template, a duplicated helix is flanked by two loop regions of different stabilities. in the "on" state, the ... | 2004 | 15286283 |
| [idiopathic spinal cord herniation which extended remarkably up- and downward from dural defect: case report]. | a case of idiopathic spinal cord herniation which extended remarkably up- and downward from a dural defect is described. a 53-year-old woman presented with numbness and pain of the right lower limb. magnetic resonance (mr) imaging revealed ventral displacement of the spinal cord and dilation of the dorsal subarachnoid space at t4-5. ct myelography showed ventral deviation of the spinal cord at the t4/5 level. a laminectomy of t3-t5 was performed, and the herniated spinal cord was untethered and ... | 2004 | 15287490 |
| treatment results of oral verrucous carcinoma and its biological behavior. | the biologic behavior of and optimal treatment for oral verrucous carcinoma (vc) remain controversial. we analyzed the clinicopathological characteristics of 12 patients with oral vc. immunohistochemical techniques were used to evaluate p53 protein, cd44 variant 9, and proliferating cell nucleus antigen. the tnm classification (uicc, 1997) was t1 in 1 patient, t2 in 3, t3 in 4, and t4 in 4. all patients were classified as n0m0. four patients were treated by surgery alone and 8 by surgery after c ... | 2004 | 15288833 |
| chest wall resection for invasive lung carcinoma, soft tissue sarcoma, and other types of malignancy. pathologic aspects in a series of 107 patients. | with improvements in surgical techniques for resection and reconstruction of the chest wall, pathologists are confronted with complicated surgical specimens. there are no currently available guidelines specifically dedicated to the handling of these specimens. extended resections of lung carcinoma chest wall invasions may change the clinical value of some tnm subsets. we reviewed a series of 107 consecutive malignant tumors involving the chest wall and resected in our institution during a 3-year ... | 2004 | 15290670 |
| thermodynamic length in a two-dimensional thermodynamic state space. | the main goal of this paper is to reach an explicit formulation and possible interpretation of thermodynamic length in a thermodynamic state space with two degrees of freedom. using the energy and entropy metric in a general form, we get explicit results about thermodynamic length along isotherms, its relation with work and with speed of sound. we also look at the relation between the determinants of the energy and entropy metrics and find that they differ by a factor of t4. | 2004 | 15291603 |
| nodavirus infections in israeli mariculture. | viral encephalopathy and retinopathy (ver) infections were diagnosed in five fish species: epinephelus aeneus, dicentrarchus labrax, sciaenops ocellatus, lates calcarifer and mugil cephalus cultured on both the red sea and mediterranean coasts of israel during 1998-2002. spongiform vacuolation of nervous tissue was observed in histological sections of all examined species. with transmission electron microscopy, paracrystalline arrays and pieces of membrane-associated non-enveloped virions measur ... | 2004 | 15291788 |
| [recurrent tumors in the oral and maxillofacial region. results and treatment strategies in 20 years]. | subject matter: following clinical diagnosis of a recurrent tumor, curative treatment is seldom available. depending on the size of the recurrent tumor and the patient's general health condition, extensive surgical resections and reconstructions are avoided in favor of nonsurgical treatment modalities with palliative intent. according to the literature, location of the tumor, tumor size and r-1 and r-2 resection rates are the most frequent reasons for the development of recurrent tumors. | 2004 | 15293116 |
| enhanced reduction and determination of trace thyroxine at carbon paste electrode in the presence of trace cetyltrimethylammonium bromide. | the electrochemical response of thyroxine (t4) at a carbon paste electrode (cpe) in the presence of cetyltrimethylammonium bromide (ctab) was investigated. it gave a well-defined oxidation peak at 0.80 v and a sensitive reduction peak at 0.40 v. compared with the indiscernible signal in the absence of ctab, the reduction current of t4 at cpe was greatly enhanced in the presence of ctab, due to the interactions between t4, ctab and the hydrophobic electrode surface. the electrode process of t4 wa ... | 2004 | 15293400 |
| comparative analytical evaluation of thyroid hormone levels in pregnancy and in women taking oral contraceptives: a study from an iodine deficient area. | increase of serum thyroxine binding globulin (tbg) resulting from estrogen action may lead to problems in thyroid diagnostics. the aim of the present study was to define the most diagnostically reliable thyroid parameters in women exposed to differentially elevated estrogens. sera of three groups of healthy women were analyzed: women taking no medicine (controls), those taking oral contraceptives and pregnant women (in weeks 16 or 32 of gestation). all women involved in the study lived in a mode ... | 2004 | 15293894 |
| the suppression of immunity by ultraviolet radiation: uva, nitric oxide and dna damage. | we have examined the mechanism by which solar-simulated ultraviolet radiation (ssuv) suppresses memory immunity to nickel in allergic humans. in initial studies, we used inbred mice to determine the contribution of different wavebands to sunlight-induced immunosuppression. we found that low dose uva can enhance memory, medium dose uva (half the amount in one minimum erythemal dose of ssuv) is immunosuppressive, but higher doses protect from uvb. this is genetically dependent, as it is not observ ... | 2004 | 15295628 |
| [selection of the optimal radiotherapy technique for locally advanced maxillary carcinoma using a three-dimensional treatment planning system]. | to compare the isodose distribution of three radiotherapy techniques for locally advanced maxillary sinus carcinoma and analyze the potential of three-dimensional (3d) conformal radiotherapy planning in order to determine the optimal technique for target dose delivery, and spare uninvolved healthy tissue structures. | 2004 | 15296119 |
| phenotypic and genotypic changes in salmonella enterica subsp. enterica serotype typhimurium during passage in intestines of broiler chickens fed on diets that included ionophore anticoccidial supplements. | the effect of continuous in-feed administration of anticoccidial agents on antimicrobial sensitivity and the level of bacterial shedding in poultry experimentally infected with salmonella enterica subsp. enterica serotype typhimurium definitive type 104 (dt104) were investigated. on day 0, 1,200 1-day-old salmonella-free broiler chicks were placed into 50 pens, and the pens were randomly allocated to one of five treatments: nonsupplemented (negative control; t1), monensin at 120 mg/kg of diet (t ... | 2004 | 15297474 |
| imaging of esophageal and gastric cancer. | the three major aims of imaging in esophageal and gastric cancer are to distinguish between locoregional and systemic disease (m stage), to determine local tumor extension (t and n stages), and to assess response to chemotherapy or chemoradiotherapy. depending on the applied standard of reference, the sensitivity of computed tomography (ct) for detection of distant metastases ranges between less than 50% to greater than 90%. in esophageal cancer, positron emission tomography with the glucose ana ... | 2004 | 15297944 |
| levels and toxicokinetic behaviors of pcdd, pcdf, and coplanar pcb congeners in common cormorants from lake biwa, japan. | concentrations of polychlorinated dibenzo-p-dioxins (pcdds), polychlorinated dibenzofurans (pcdfs), and coplanar polychlorinated biphenyls (co-pcbs) were determined in the liver and pectoral muscle of common cormorants (phalacrocorax carbo) collected from lake biwa, japan. to clarify the toxicokinetic behaviors and potential toxicities of these chemicals, the present study addresses life-stage- and tissue-specific accumulation of the congeners. total 2,3,7,8-tetrachlorodibenzo-p-dioxin toxic equ ... | 2004 | 15298192 |
| methylprednisolone prevents inflammatory reaction occurring during cardiopulmonary bypass: effects on tnf-alpha, il-6, il-8, il-10. | this study examined the correlation between tumour necrosis factor-alpha (tnf-alpha), interleukin (il)-6 and il-8, il-10 and methylprednisolone pretreatment. | 2004 | 15298427 |
| enhancement of the method of molecular replacement by incorporation of known structural information. | crystals of macromolecules often have two or more molecules per asymmetric unit, or contain domains of a macromolecule or a macromolecular complex that are structurally independent. in such cases the conventional molecular-replacement method attempts to determine the position of each structural unit independently. typically, some parts of the structure can be determined more easily or more reliably than other parts. methods are proposed whereby information from a part of a crystal structure that ... | 1994 | 15299365 |
| crystallization and preliminary x-ray analysis of bacteriophage t4 deoxynucleotide kinase. | t4 deoxynucleotide kinase catalyzes the phosphorylation of 5-hydroxymethyldeoxycytidylate, dtmp and dgmp while excluding dcmp and damp. in order to understand the mechanism of this remarkable specificity, the enzyme was over-expressed in escherichia coli, purified and crystallized for x-ray diffraction analysis. the crystals belong to the monoclinic space group c2 with cell dimensions a = 155.2, b = 58.5, c = 75.7 a, beta = 108.1 degrees. there are two protein monomers in the asymmetric unit rel ... | 1996 | 15299754 |
| changes in human eeg caused by low level modulated microwave stimulation. | this study focuses on the effect of low level microwave radiation on human eeg alpha and theta rhythms. during the experiment, 20 healthy volunteers were exposed to a 450 mhz microwaves with 7 hz on-off modulation. the field power density at the scalp was 0.16 mw/cm2. signals from the following eeg channels were used: fp1, fp2, p3, p4, t3, t4, o1, and o2. the experimental protocol consisted of one cycle of short term photic and ten cycles of the repetitive microwave stimulation. the changes caus ... | 2004 | 15300729 |
| the utility of a two-color fluorescence electrophoretic mobility shift assay procedure for the analysis of dna replication complexes. | protein-dna and protein-protein interactions play essential roles in many biologic processes such as transcription, replication, recombination, and dna repair. one of the most popular approaches to investigate specific protein-nucleic acid interactions is the electrophoretic mobility shift assay (emsa). we have developed a new nonradioactive method to detect both nucleotides and protein in emsa. nucleic acids are detected with sybr green emsa dye, while proteins are subsequently detected with sy ... | 2004 | 15300760 |
| the use of l-t4 as liquid solution improves the practicability and individualized dosage in newborns and infants with congenital hypothyroidism. | dosage recommendations for the initial therapy of congenital hypothyroidism (ch) in newborns vary between 8 microg/kg/d and 10-15 microg/kg/d. | 2004 | 15301044 |
| multivariate analysis of factors predictive of brain metastases in localised non-small cell lung carcinoma. | brain metastases are a frequent feature of the course of non-small cell lung carcinoma (nsclc). the potential usefulness of prophylactic cranial irradiation (pci) has led to the search for target groups likely to derive benefit. this multivariate analysis looked for factors predictive of brain metastases in a group of stages i-iii nsclc patients under care of the thoracic oncology unit of besançon university hospital from 1977 to 2001. all the patients had the same follow-up. they were divided i ... | 2004 | 15301872 |
| progressive changes in met-dependent signaling in a human ovarian surface epithelial model of malignant transformation. | we used an experimental in vitro model of human ovarian surface epithelium (ose), the tissue of origin of >90% of ovarian cancers, to more precisely define the contribution of hepatocyte growth factor (hgf) to various ose phenotypes at different stages of neoplastic progression. neoplastic transformation of ose in cultures was achieved by multiple genetic manipulations, resulting in the nontumorigenic line iose-29, the tumorigenic iose-ov29, and the tumor-derived, more highly malignant iose-ov29 ... | 2004 | 15302591 |
| [practice guidelines for lung cancer invading the neighboring anatomic structures]. | lung cancers invading the neighboring anatomic structures such as the chest wall, diaphragm, great vessels (superior vena cava, aorta, left atrium, etc.), and tracheal carina are categorized as t3 or t4, and are regarded as locally advanced lung cancer. the surgical indications mode of resection, and combined treatment for these tumors have been important issues. however, the scientific evidence from comparative studies, which serve as the basis for practice guidelines is very scant for these ca ... | 2004 | 15303440 |
| adverse effects of mercuric chloride on thyroid of mice, musculus albinus and pattern of recovery of the damaged activity. | the protective role of "essentiale phospholipids" (epl) on mercury induced thyroid dysfunction with special reference to cholesterol, thyroid peroxidase and thyroxine activity in mice were investigated. the animals were treated with 0.5 ml/day of 0.5 ppm aqueous mercuric chloride for a period of 7, 14 and 21 days. for the recovery 175 mg of epl was given to mice (already treated with hgcl2) for a period of 7, 14 and 21 days. daily treatment of hgcl2 for 7, 14 and 21 days decreased serum choleste ... | 2004 | 15303713 |
| a phase i trial of preoperative radiotherapy and capecitabine for locally advanced, potentially resectable rectal cancer. | the purpose of the study was to determine the maximum-tolerated dose (mtd) of oral capecitabine, combined with concurrent, standard preoperative pelvic radiotherapy, when given twice daily, from monday to friday throughout the course of radiotherapy, for locally advanced potentially resectable rectal cancer. maximum-tolerated dose was defined as the total (given in two equally divided doses) oral dose of capecitabine that caused treatment-related grade 3 or 4 toxicity in one-third or more of the ... | 2004 | 15305186 |
| cervical epidural analgesia via a thoracic approach using nerve stimulation guidance in an adult patient undergoing elbow surgery. | this case report describes the placement of a cervical epidural catheter via the thoracic approach, using nerve stimulation, in a patient undergoing elbow surgery. | 2004 | 15305256 |
| high-frequency generalised transduction by bacteriophage t4. | | 1979 | 15305587 |
| prognostic significance of tumour size in patients after tumour nephrectomy for localised renal cell carcinoma. | staging of the primary tumour is accepted as the most important prognostic factor in organ confined renal cell carcinoma. | 2004 | 15306102 |
| incidence of low free t4 values in premature infants as determined by direct equilibrium dialysis. | the incidence of transient reductions in serum free t(4) (ft(4)) in premature infants may be overestimated because certain ft(4) analytical methods underestimate ft(4) concentrations. transient reductions of ft(4) measurements have been reported in the majority of premature newborn infants. direct equilibrium dialysis (ded) does not underestimate ft(4) concentrations and is the best available technique to measure serum ft(4) in the premature infant. | 2004 | 15306825 |
| [jugular neck dissection for supraglottic laryngeal carcinoma with negative clinical findings in the neck (n0)]. | appropriate management of patients with supraglottic laryngeal carcinoma and negative findings in the neck is still controversial. a prospective and retrospective study comprised 193 patients who were treated primary surgically between 1976 and 1993. they all had clinically and ultrasound negative findings on the neck (n0). supraglottic carcinomas usually spread regionally. metastases develop in the jugular group, between level ii-iv. the incidence of metastases has been reported to vary from 12 ... | 2004 | 15307306 |
| propylthiouracil reduces the effectiveness of radioiodine treatment in hyperthyroid patients with graves' disease. | in order to assess the effect of propylthiouracil (ptu) or methimazole (mmi) pretreatment on patient outcome after radioiodine therapy, we examined 100 patients with graves' disease 3, 6, 9, and 12 months after administration of a 10-mci standard single dose of 131i. they were assigned to one of three groups: no drug (nd) treatment (30 cases); mmi (45 cases); and ptu (25 cases). antithyroid drugs (atd) were withdrawn 15 days before radioiodine administration. the groups were similar concerning a ... | 2004 | 15307942 |
| clinical implications of p53 mutation analysis in bladder cancer tissue and urine sediment by functional assay in yeast. | in the present study we correlate the p53 gene mutations in tumour tissue with urine sediment using a functional assay in yeast, and relate the p53 status to the outcome in a group of patients with transitional cell carcinoma of the bladder. the p53 mutations were found in three of 30 (10%) ta/t1 tumour tissue samples and in two of 20 (10%) corresponding urine sediments. in the stage t2-t4 tumour p53 mutations were found in tumour tissues and urine sediments in 13 of 31 (42%) and in seven of 18 ... | 2004 | 15308588 |
| transient paraparesis after laminectomy in a patient with multi-level ossification of the spinal ligament. | acute neurologic deterioration is not a rare event in the surgical decompression for thoracic spinal stenosis. we report a case of transient paraparesis after decompressive laminectomy in a 50-yr-old male patient with multi-level thoracic ossification of the ligamentum flavum and cervical ossification of the posterior longitudinal ligament. decompressive laminectomy from t9 to t11 was performed without gross neurological improvement. two weeks after the first operation, laminoplasty from c4 to c ... | 2004 | 15308861 |