| correlation between oxygen consumption calculated using fick's method and measured with indirect calorimetry in critically ill patients. | to compare the oxygen consumption index measured by using indirect calorimetry (vo2i delta) with a portable metabolic cart and calculated according to fick's principle (vo2 i fick) in critically ill patients. | 2004 | 14978596 |
| [vertebral hemangioma extending into the spinal canal: case report]. | a 73-year-old woman was admitted to our hospital presenting slowly progressive hypoesthesia below the 5th thoracic dermatome and spastic paraparesis. computed tomography (ct) and magnetic resonance imaging (mri) revealed a mass lesion in the t3 vertebral body extending into the spinal canal. the spinal cord was compressed to the left side and right t3 and t4 nerve roots were encased in the mass lesion. one week after admission, t2-t4 laminectomy was performed to relieve the spinal cord compressi ... | 2004 | 14978923 |
| laparoscopic gastric bypass in patients on thyroid replacement therapy for subnormal thyroid function - prevalence and short-term outcome. | hypothyroidism is associated with increased body weight. weight gain may occur despite normal levels of serum thyroid stimulating hormone (tsh) and thyroxine (t4) achieved by replacement therapy. we evaluated the prevalence of patients on thyroid replacement for subnormal thyroid function who were operated on for morbid obesity and monitored their postoperative weight loss pattern. | 2004 | 14980041 |
| l-homoserylaminoethanol, a novel dipeptide alcohol inhibitor of eukaryotic dna polymerase from a plant cultured cells, nicotina tabacum l. | we found a novel inhibitor specific to eukaryotic dna polymerase epsilon(pol epsilon) from plant cultured cells, nicotina tabacum l. the compound (compound 1) was a dipeptide alcohol, l-homoserylaminoethanol. the 50% inhibition of pol epsilon activity by the compound was 43.6 microg/ml, and it had almost no effect on the activities of the other eukaryotic dna polymerases such as alpha, beta, gamma and delta, prokaryotic dna polymerases, nor dna metabolic enzymes such as human telomerase, human i ... | 2004 | 14980608 |
| thyroid function and the development of endothermy in a marsupial, the tasmanian bettong, bettongia gaimardi (demarest 1822). | the tasmanian bettong (bettongia gaimardi) is a small rat-kangaroo (marsupial) found only in tasmania, australia. the duration of pouch life is 15 weeks. adults and older young display non-shivering thermogenesis and this paper examines the role of thyroxine in the development of endothermy in pouch young. free thyroxine (t4) concentrations varied throughout pouch life. the mean (+/-se) concentration was 6.2+/-1.9 pmol l(-1) in week 7, increased and peaked at 19.2+/-4.3 pmol l(-1) in week 12, an ... | 2004 | 14980792 |
| low dose exposure to sodium arsenite synergistically interacts with uv radiation to induce mutations and alter dna repair in human cells. | inorganic arsenic is a known human carcinogen, yet its mechanism of action remains poorly understood. epidemiological data suggest that arsenic exposure interacts with uv radiation exposure to increase the risk of skin cancer. studies have suggested that arsenic is able to impair dna repair enzymes and alter the repair of uv-induced dna damage. here we have tested the hypothesis that arsenite [as(iii)] and uv interact synergistically to enhance mutagenesis. tk6 human lymphoblastoid cells that ar ... | 2004 | 14981161 |
| symptomatic relief of patients with advanced bladder carcinoma after regional intra-arterial chemotherapy. | thirty-two patients (30 men, 2 women), median age 68 years (range 47-85) with histologically confirmed advanced bladder carcinoma (stages t3 and t4 according to the international union against cancer staging system), who were poor surgical candidates, were prospectively treated with 1-6 (median 4) cycles of intra-arterial epirubicin (60 mg/cycle) delivered through two infusion pumps that were surgically implanted to each internal iliac artery, along with intravenous leucovorin 200 mg per day and ... | 2003 | 14981980 |
| effects of hypothyroidism on the estrous cycle and reproductive hormones in mature female rat. | the present study was undertaken to examine the systemic role of thyroid hormones by analyzing changes in reproductive functions in hypothyroid female rats. serum concentrations of triiodo-thyronine (t3) significantly decreased 1 week after the initiation of propyl-thiouracil treatment or thyroidectomy. the estrous cycle became irregular 3 and 2 weeks after the initiation of propyl-thiouracil treatment and thyroidectomy, respectively. serum luteinizing hormone (lh) levels significantly reduced i ... | 2004 | 14985057 |
| study of trace elements in blood of thyroid disorder subjects before and after 131i therapy. | both trace elements and thyroid hormones play essential roles in the human body. however, the previous results about the interaction between these two factors are often controversially given. in order to make clear the influence of thyroid hormones on the homeostasis of trace elements, we studied the variation of fe, cu, and zn in erythrocyte and serum from patients with hyperthyroidism before and after 131i therapy by the x-ray fluorescence method. the different thyroid statuses of the patients ... | 2004 | 14985623 |
| mice with targeted disruption of the dio2 gene have cold-induced overexpression of the uncoupling protein 1 gene but fail to increase brown adipose tissue lipogenesis and adaptive thermogenesis. | the dio2 gene encodes the type 2 deiodinase (d2) that activates thyroxine (t4) to 3,3',5-triiodothyronine (t3), the disruption of which (dio2(-/-)) results in brown adipose tissue (bat)-specific hypothyroidism in an otherwise euthyroid animal. in the present studies, cold exposure increased dio2(-/-) bat sympathetic stimulation approximately 10-fold (normal approximately 4-fold); as a result, lipolysis, as well as the mrna levels of uncoupling protein 1, guanosine monophosphate reductase, and pe ... | 2004 | 14988240 |
| increasing incidence of childhood thyrotoxicosis in a population-based area of central sweden. | to study the incidence, prevalence and clinical characteristics of childhood thyrotoxicosis in a population-based area comprising five counties in central sweden. | 2004 | 14989435 |
| pet with [18f]fluorothymidine for imaging of primary breast cancer: a pilot study. | the aim of this study was to evaluate the use of [(18)f]fluorothymidine (flt) as a positron emission tomography (pet) tracer for the diagnosis of breast cancer. to this end, 12 patients with 14 primary breast cancer lesions (t2-t4) were studied by flt-pet. for comparison, [(18)f]fluorodeoxyglucose (fdg) pet scans were performed in six patients. thirteen of the 14 primary tumours demonstrated focally increased flt uptake (suv(mean)=3.4+/-1.1). seven out of eight patients with histologically prove ... | 2004 | 14991243 |
| reduced selenium-binding protein 1 expression is associated with poor outcome in lung adenocarcinomas. | the effects of selenium, an essential nutrient with anti-carcinogenic properties, are mediated by selenium-binding proteins. the protein expression status of human selenium-binding protein 1 (sbp1) in human tumours and the exact function of this protein are not known. in this study, quantitative two-dimensional polyacrylamide gel electrophoresis (2-d page) was used on 93 lung adenocarcinomas and ten uninvolved lung samples. two likely isoforms of a 56 kd protein that showed a significantly decre ... | 2004 | 14991897 |
| rna ligase; picking up the pieces. | in the current issue of structure, ho and coworkers report the crystal structure and mechanism of a t4 rna ligase. these studies provide valuable insights on the mechanism and origin of rna and dna ligases, and rna capping enzymes. | 2004 | 14992715 |
| peripheral intrapulmonary lymph node metastases of non-small-cell lung cancer. | since the development and progress of computed tomographic imaging, peripheral intrapulmonary lymph nodes (iplns) have become increasingly described and well-known entities. intrapulmonary lymph nodes may appear as a solitary pulmonary nodular shadow mimicking a non-small-cell lung cancer (nsclc) or as multiple nodules masquerading as carcinoma metastases. we describe a case in which iplns presented as a clinical "nodular" t4 n0 nsclc that finally proved to be a pathologic t2 n1 nsclc, thus rais ... | 2004 | 14992944 |
| role of endoscopic ultrasonography in preoperative staging of gastric carcinoma. | preoperative staging of tumour extent in upper gastrointestinal malignancy greatly facilitates planning of therapy. the present study was undertaken to see whether preoperative endoscopic ultrasonography (eus) accurately predicts the tumour stage in gastric carcinoma. | 2004 | 14996154 |
| accuracy of eus in staging of t4 lung cancer. | increasingly, eus is being used to stage lung cancer. direct mediastinal invasion (t4) by lung cancer is stage iiib disease. patients in this stage have a 5-year survival of less than 5% and generally are offered chemotherapy without surgery. this study evaluated the accuracy of eus in detecting t4 lung cancer. | 2004 | 14997129 |
| phase ii study of neoadjuvant paclitaxel and cisplatin for operable and locally advanced breast cancer: analysis of 126 patients. | in an earlier study, we have demonstrated a high clinical and pathologic response rate of neoadjuvant paclitaxel (p) and cisplatin (c) for patients with locally advanced breast cancer (labc). the current phase ii study includes larger number of patients who had longer follow-up. a total of 126 consecutive patients with noninflammatory labc (t2 >4 cm, t3 or t4, n0-n3, m0) were included in the study. patients were scheduled to receive three to four cycles of the neoadjuvant pc (paclitaxel 135 mg m ... | 2004 | 14997191 |
| effect of iodinated contrast media on thyroid function in adults. | excess free iodide in the blood (ingested or injected) may cause thyrotoxicosis in patients at risk. iodinated contrast medium solutions contain small amounts of free iodide and may be of significance for patients at risk. the free iodide may also interfere with nuclear medicine diagnostic studies and treatment. therefore the contrast media safety committee of the european society of urogenital radiology reviewed the literature on this subject in order to prepare guidelines. a report and guideli ... | 2004 | 14997334 |
| perioperative levels of interleukin-1beta and interleukin-6 in women with breast cancer. | proinflammatory cytokines, such as interleukin-1beta and interleukin-6, are known to play an important biological role in trauma, sepsis and malignant disease. surgery can modulate the immune system, especially in patients with malignant diseases, by influencing the serum levels of interleukin-1beta and interleukin-6. it is known that cytokine levels depend on the grade of tissue injury. we have investigated the serum levels of interleukin-1beta and interleukin-6 during the perioperative period ... | 2004 | 14998180 |
| assessment of de-71, a commercial polybrominated diphenyl ether (pbde) mixture, in the edsp male and female pubertal protocols. | de-71, a commercial mixture, was used to test the sensitivity of the female and male pubertal protocol to detect thyroid active chemicals. these protocols are being evaluated for the u.s. epa's endocrine disruptor screening program as part of a tier i screening battery. to examine the ability of these protocols to screen for chemicals that induce the clearance of thyroid hormone, we examined male and female wistar rats following de-71 exposure. rats were gavaged daily with 0, 3, 30, or 60 mg/kg ... | 2004 | 14999130 |
| evaluation of the effects of radiotherapy to the chiasm and optic nerve by visual psychophysical and electrophysiologic tests in nasopharyngeal carcinoma. | to evaluate the effects of high-dose radiotherapy (rt) to the chiasm and optic nerves in locally advanced nasopharyngeal carcinoma patients by visual psychophysical and electrophysiologic tests. | 2004 | 15001256 |
| the importance of aprotinin and pentoxifylline in preventing leukocyte sequestration and lung injury caused by protamine at the end of cardiopulmonary bypass surgery. | protamine has adverse effects on pulmonary gas exchange during the postoperative period. the objective of this study was to investigate the importance of aprotinin and pentoxifylline in preventing the leukocyte sequestration and lung injury caused by protamine administered after the termination of cardiopulmonary bypass (cpb). | 2004 | 15002070 |
| euromir 95 t4 experiment 'human posture in microgravity': global results and future perspectives. | after 7 years of studies on euromir 95 t4 experiment 'human posture in microgravity' dataset, some important remarks can be proposed for best exploiting future experimental campaigns as well as for neurophysiological investigations on-ground. the main focus of such experiments was to monitor the process of learning and adapting to the new environment in performing complex voluntary movements. euromir 95 was the first quantitative investigation with high technology instrumentation (elite-s) invol ... | 2002 | 15002510 |
| tnm classification for lung cancer. | the international tumor-node-metastasis (tnm) staging system is the "international language" in cancer diagnosis and treatment. six revisions of the tnm staging system for lung cancer have been repeated over the past 35 years after the beginning of uicc-tnm classification in 1968. the 1997 revision for lung cancer has undergone an extensive correction for many deficiencies of the old staging system. as a result, the new staging system appears to be a great improvement over previous editions. the ... | 2003 | 15003094 |
| serum levels of interleukin-18 and nitrite+nitrate in renal cell carcinoma patients with different tumor stage and grade. | interleukin (il-18) and nitric oxide (no) are immunoregulatory cytokines that have been suggested to participitate in the multistep process of carcinogenesis. in this study, serum il-18 and nitrite+nitrate levels (as an index of no generation) were measured in 26 patients with histologically confirmed renal cell carcinoma (rcc) before surgical procedure and in 8 healthy controls. rcc patients showed significantly higher serum il-18 levels when compared to the control subjects (p<0.001). serum il ... | 2004 | 15004655 |
| diffusion constant in gel electrophoresis at high fields. | we present new measurements of the diffusion constant d in standard (slab-gel) electrophoresis of dna at fields up to 10 v/cm. molecules investigated are bacteriophages: t4 of length 173 kbp and lambda of length 48.5 kbp cut by restriction enzyme hindiii. we show, that d increases with the molecule length for electric field e above 5 v/cm. the results are interpreted within the geometration model. | 2004 | 15004836 |
| diagnostic effectiveness of simultaneous thyroxine and thyroid-stimulating hormone screening measurements. thirteen years' experience in the northeast italian screening programme. | to evaluate the effectiveness of thyroid-stimulating hormone (tsh) and thyroxine (t4) measurements at neonatal screening for congenital hypothyroidism, we compared our false-negative results with those we would have obtained if we had used tsh screening alone. | 2004 | 15006107 |
| [two younger male patients with rapidly progressing pulmonary pleomorphic carcinoma]. | we report 2 cases of pulmonary pleomorphic carcinoma. the patient in case 1 was a 44-year-old man who was admitted to our hospital complaining of dry cough and dyspnea on exertion. chest radiography and ct showed a huge tumor with left pleural effusion. percutaneous biopsy suggested malignancy. as distant metastasis was not found and as cytological examination of pleural effusion gave a result of class ii, we attempted to perform left pneumonectomy. however, we performed partial resection of the ... | 2004 | 15007917 |
| iodine supplementation restores fertility of sheep exposed to iodine deficiency. | the aims of the study were to monitor sheep iodine intake in different sheep breeding farms in abruzzo and to evaluate the effects of iodine supplementation on ovine fertility. the urinary iodine concentrations (uic) in animals of 8 out of the 11 breeding farms analyzed were borderline (uic 100-150 microg/l) or very low (uic < or = 50 microg/l). only animals bred in 3 farms showed an adequate iodine intake with a mean uic > or = 300 microg/l. animals with very low iodine intake had lower t4 and ... | 2003 | 15008245 |
| hypothyroidism associated with anti-human chorionic gonadotropin antibodies secondarily produced by gonadotropin therapy in a case of idiopathic hypothalamic hypogonadism. | we report a 22-yr-old male patient with idiopathic hypothalamic hypogonadism who showed secondary resistance to gonadotropin (gn) therapy over 3 yr after successful treatment with hcg combined with human menopausal gn. the patient simultaneously developed subclinical hypothyroidism. endocrine examination revealed low levels of testosterone (0.3 ng/ml), free t4 (0.91 ng/dl), and increased levels of tsh (31.1 microu/ml) in the serum. serum autoantibodies to thyroid gland were all negative. interes ... | 2003 | 15008254 |
| administration of a single dose of recombinant human thyrotrophin enhances the efficacy of radioiodine treatment of large compressive multinodular goitres. | patients with very large multinodular goitres, frequently found among elderly people, often suffering from cardiovascular or other disabling disorders, may be considered as unsuitable for surgery. we have evaluated the feasibility of relatively high-dose 131i therapy in such patients. as subclinical or clinical hyperthyroidism is commonly found in these patients, associated with a low radioiodine (rai) uptake at 24 h, we pretreated a group of patients with a single intramuscular injection of rec ... | 2004 | 15008994 |
| thyroid function in girls with epilepsy with carbamazepine, oxcarbazepine, or valproate monotherapy and after withdrawal of medication. | antiepileptic drugs may affect the serum thyroid hormone concentrations. the aim of this study was to evaluate thyroid function in 78 girls taking carbamazepine (cbz), oxcarbazepine (oxc), or valproate (vpa) monotherapy for epilepsy and after withdrawal of the treatment. | 2004 | 15009219 |
| differentiated thyroid carcinoma: the new uicc 6th edition tnm classification system in a retrospective analysis of 169 patients. | to compare the new, 6th edition, uicc tnm staging system with the former edition, we updated tnm staging in patients with differentiated thyroid carcinoma. | 2004 | 15009916 |
| expression of smac/diablo is a novel prognostic marker in lung cancer. | recently smac/diablo (second mitochondria-derived activator of caspase) has been identified as a proapoptotic protein that inhibits iaps (inhibitors of apoptosis proteins). smac is expressed ubiquitously in many organs, including the lung. here we evaluated the expression of smac mrna with real-time reverse-transcription pcr in 88 primary lung cancers and matched normal tissues. smac mrna expression in tumor tissues was significantly lower than that in normal tissues (p<0.0001). in squamous cell ... | 2004 | 15010875 |
| k-ras and p16(ink4a)alterations in sputum of nsclc patients and in heavy asymptomatic chronic smokers. | nsclc rates among the most frequent and lethal neoplasm world-wide and a significant decrease in morbidity and mortality relies only upon effective early diagnostic strategies. we investigated k-ras mutations and p16(ink4a) hypermethylation in tumor tissue and sputum of 50 patients with nsclc and correlated them with sputum cytology and with tumor staging, grading and location, to ascertain, in sputum, their potential diagnostic impact. the same genetic/epigenetic abnormalities and cytological f ... | 2004 | 15013580 |
| [study on midazolam used for awake blind intubation of maxillofacial surgery]. | to provide clinical data for midazolam to be used as an assistant drug for awake tracheal intubation. | 2000 | 15014819 |
| effect of distraction osteogenesis on the severely hypoplastic mandible and inferior alveolar nerve function. | the purpose of this study was to examine the effect of distraction osteogenesis surgery on the inferior alveolar nerve (ian) and on the stability of the occlusion in patients undergoing mandibular osteotomy and advancement for correction of severe retrognathia. | 2004 | 15015160 |
| chronic glue sniffing with transient central hypothyroidism and hypergonadotropism. | neuropsychiatric, gastrointestinal and muscular disorders associated with glue sniffing have been widely reported, but endocrinologic abnormalities of glue exposure are rarely mentioned in the literature. we report a 26-year old male patient, a chronic glue sniffer, who presented with weakness of both lower limbs. on physical examination, he had reduced muscle strength of his 4 limbs, especially in his lower limbs. laboratory examination revealed hypokalemia with hyperchloremic metabolic acidosi ... | 2003 | 15015825 |
| solution structures of reduced and oxidized bacteriophage t4 glutaredoxin. | | 2004 | 15017142 |
| putative l-triiodothyronine receptors in the liver nuclei of mature tropical toad, bufo melanostictus. | thyroid hormones exert a major role in growth and differentiation of almost all types of tissues in animals, particularly in amphibian metamorphosis, through its specific nuclear receptor activation followed by gene expression. however, its function in mature tropical amphibians is less studied. the present study revealed the existence of a single class of specific nuclear receptor(s) in the liver nuclei of mature tropical toad, bufo melanostictus, with a dissociation constant of (3.7 +/- 0.9) x ... | 2004 | 15018064 |
| altered thyroid status in lake trout (salvelinus namaycush) exposed to co-planar 3,3',4,4',5-pentachlorobiphenyl. | recent studies indicate that co-planar 3,3',4,4',5-pentachlorobiphenyl (pcb) congeners or their metabolites may disrupt thyroid function in fishes. although co-planar pcb have been detected at microgram per kilogram levels in fish from contaminated areas, few studies have examined mechanisms whereby, co-planar pcbs may alter thyroid function in fish. we treated immature lake trout by intraperitoneal (i.p.)-injection or dietary gavage with vehicle containing 0, 0.7, 1.2, 25 or 40 microg 3,3',4,4' ... | 2004 | 15019252 |
| chemical synthesis and translesion replication of a cis-syn cyclobutane thymine-uracil dimer. | the cytosine base in dna undergoes hydrolytic deamination at a considerable rate when uv radiation induces formation of a cyclobutane pyrimidine dimer (cpd) with an adjacent pyrimidine base. we have synthesized a phosphoramidite building block of a cis-syn cyclobutane thymine-uracil dimer (t[]u), which is the deaminated form of the cpd at a tc site, and incorporated it into oligodeoxyribonucleotides. the previously reported method for synthesis of the thymine dimer (t[]t) was applied, using part ... | 2004 | 15020710 |
| comparison of plasma epstein-barr virus (ebv) dna levels and serum ebv immunoglobulin a/virus capsid antigen antibody titers in patients with nasopharyngeal carcinoma. | serologic measurement of antibodies to epstein-barr virus (ebv) immunoglobulin a/viral capsid antigen (iga/vca) and early antigen (iga/ea) has been used widely to screen for nasopharyngeal carcinoma (npc) in china. recently, it was found that plasma ebv dna concentration is an indicator for the staging and prognosis of patients with npc. to determine whether there is a correlation between plasma ebv dna levels and serum levels of iga/vca, the authors measured both in patients with npc and in a c ... | 2004 | 15022282 |
| quality of colon carcinoma pathology reporting: a process of care study. | in 1996, the association of directors of anatomic and surgical pathology (adasp) published recommendations for colon carcinoma reporting. since this publication, no study has evaluated physician practice in relation to these recommendations. the objectives of the current study were to describe pathology reporting for colon carcinoma, evaluate potential variations in reporting, and identify areas for improvement. | 2004 | 15022295 |
| [diagnosis and treatment of bladder cancer]. | the authors present a retrospective analysis of the results of transurethral conservative and radical operations in 125 patients with invasive cancer of the urinary bladder (ub) treated in the research institute of urology throughout 1992-2002. transurethral resection (tur) of the ub was made in 72 patients. stages pt2a, pt2b, t3 and t4 were diagnosed in 23 (31.9%), 18 (25%), 14 (19.5%) and 17 (23.6%) cases, respectively. 53 patients with advanced invasive ub cancer have undergone radical cystec ... | 2004 | 15022437 |
| [role of thyroid hormones in regulation of heart function]. | current data on mechanisms of action of thyroid hormones--t3 and t4--on molecular, cellular and organic organs obtained in experimental and clinical conditions are reviewed. the results of examination of patients with hypo- and hyperthyroidism as well as some clinical syndromes (heart arrhythmia, heart failure) have shown physiological and pathophysiological participation of thyroid hormones in regulation of cardiac activity at the level of hemodynamics and myocardial metabolism. | 2004 | 15022589 |
| [hormonal dysregulation of lipid metabolism in pathogenesis of ischemic heart disease]. | the aim of the study was to specify postprandial hyperlipidemia (phl) and the level of hormones which regulate metabolism, lipids in particular, in patients with ischemic heart disease (ihd) vs those in healthy persons and patients with thyrotoxicosis as well as to clarify whether ihd pathogenesis correlates with fat metabolism disturbance. lipid and apoprotein parameters of dyslipoproteinemia, concentrations of insulin, hydrocortisone, t3, t4 and thyrotropic hormone were tested before and 3, 6 ... | 2004 | 15022592 |
| role of radiation therapy for facial skin cancers. | radiation therapy is one of many modalities that should be considered and explained to patients with basal cell carcinomas and squamous cell carcinomas of the head and neck (fig. 2). control rates for appropriately selected patients should exceed 90% and historically are comparable with most surgical resections. for locally advanced t4 lesions, a combined modality approach will give the best chance at local control. postoperative radiation therapy is indicated in patients with advanced lesions, ... | 2004 | 15022791 |
| ligating dna with dna. | cloning dna typically involves the joining of target dnas with vector constructs by enzymatic ligation. a commonly used enzyme for this reaction is bacteriophage t4 dna ligase, which requires atp as the energy source to catalyze the otherwise unfavorable formation of a phosphodiester bond. using in vitro selection, we have isolated a dna sequence that catalyzes the ligation of dna in the absence of protein enzymes. we have used the action of two catalytic dnas, an atp-dependent self-adenylating ... | 2004 | 15025472 |
| differential expression of iodothyronine deiodinase type 2 in growth plates of chickens divergently selected for incidence of tibial dyschondroplasia. | tibial dyschondroplasia (td) is a genetic leg defect in broilers with a lesion of avascular, non-calcified cartilage below the growth plate of the proximal tibiatarsus. this disease is considered to result from the inability of chondrocytes to undergo terminal differentiation. thyroid hormones are required for chondrocyte differentiation. the thyroid gland produces and secrets mostly l-thyroxine or t4 and t4 plays most of its biological activities through conversion to triiodothyronine or t3 in ... | 2004 | 15025570 |
| distribution, sequence homology, and homing of group i introns among t-even-like bacteriophages: evidence for recent transfer of old introns. | self-splicing group i introns are being found in an increasing number of bacteriophages. most introns contain an open reading frame coding for a homing endo-nuclease that confers mobility to both the intron and the homing endonuclease gene (heg). the frequent occurrence of intron/heg has raised questions whether group i introns are spread via horizontal transfer between phage populations. we have determined complete sequences for the known group i introns among t-even-like bacteriophages togethe ... | 2004 | 15026408 |
| prognostic variables for cancer-related survival in node-negative colorectal carcinomas. | the efficacy of adjuvant treatment in node-negative colorectal carcinoma is unproven. the purpose of this study was to analyze the prognostic value of routinely detectable clinicopathological variables in order to identify subgroups of node-negative colorectal cancer patients at a high risk of a recurrence. | 2004 | 15026608 |
| alterations in thyroid hormone concentrations in healthy sled dogs before and after athletic conditioning. | to determine effects of athletic conditioning on thyroid hormone concentrations in a population of healthy sled dogs. | 2004 | 15027682 |
| expression of the p65 gene in patients with colorectal cancer: comparison with some histological typing, grading and clinical staging. | p65 protein/gene is a potential, non-specific tumour marker expressed by different types of neoplasms. in this study p65 gene expression was estimated in a group of colorectal cancers and compared with some histological features, grading and clinical staging of the neoplasms to assess its role as a prognostic marker for colorectal cancer. | 2004 | 15028307 |
| the clinicopathological significance of inferior mesenteric lymph node metastasis in colorectal cancer. | there are few studies reporting survival or recurrence patterns in colorectal cancer patients with inferior mesenteric lymph node metastasis (imln+). the present study evaluated the prognostic significance of patients being imln+ or imln- in colorectal cancer. | 2004 | 15028308 |
| accelerated postoperative radiotherapy with weekly concomitant boost in patients with locally advanced head and neck cancer. | to assess the feasibility and efficacy of accelerated 66-gy postoperative radiotherapy (port) using a single-fraction regimen from mondays to thursdays and a concomitant boost on friday afternoon sessions in patients with locally advanced head and neck cancer (lahnc). | 2004 | 15028406 |
| [psychiatric manifestations of vitamin b12 deficiency: a case report]. | psychiatric manifestations are frequently associated with pernicious anemia including depression, mania, psychosis, dementia. we report a case of a patient with vitamin b12 deficiency, who has presented severe depression with delusion and capgras' syndrome, delusion with lability of mood and hypomania successively, during a period of two months. case report - mme v., a 64-year-old woman, was admitted to the hospital because of confusion. she had no history of psychiatric problems. she had histor ... | 2003 | 15029091 |
| pseudoaneurysm of the thoracic radiculomedullary artery with subarachnoid hemorrhage. case report. | the authors report a rare case of a patient with a left-sided t-5 radiculomedullary artery pseudoaneurysm who presented with spinal subarachnoid hemorrhage (sah). the patient, a 71-year-old woman, was hospitalized for progressive paraplegia and sensory loss with bladder and rectal dysfunction. computerized tomography scanning revealed an sah at the posterior fossa. spinal t2-weighted magnetic resonance imaging demonstrated sah and an inhomogeneous and slightly low signal intensity mass at t4-5. ... | 2004 | 15029924 |
| [intraarterial chemotherapy with bladder preservation in patients with invasive bladder carcinoma]. | intraarterial chemotherapy (iac) was carried out on patients with invasive bladder carcinoma to treat the bladder carcinoma while preserving the bladder. fifteen patients with bladder carcinoma at stage t2-t4 were treated with intraarterial cisplatin (cddp: 70 mg/m2) and adriamycin (adm: 30 mg/m2) every 3 to 4 weeks. the response was observed in all 15 patients. ten (66.7%) achieved a complete response (cr), and 3 (20.0%) obtained a partial response (pr). with a mean follow-up of 22.6 months, th ... | 2004 | 15032009 |
| very fast folding and association of a trimerization domain from bacteriophage t4 fibritin. | the foldon domain constitutes the c-terminal 30 amino acid residues of the trimeric protein fibritin from bacteriophage t4. its function is to promote folding and trimerization of fibritin. we investigated structure, stability and folding mechanism of the isolated foldon domain. the domain folds into the same trimeric beta-propeller structure as in fibritin and undergoes a two-state unfolding transition from folded trimer to unfolded monomers. the folding kinetics involve several consecutive rea ... | 2004 | 15033360 |
| inhibition of the activity of the native gamma-aminobutyric acid a receptor by metabolites of thyroid hormones: correlations with molecular modeling studies. | to characterize the direct effects of thyroid hormones on native gamma-aminobutyric acid(a) (gaba(a)) receptors, rapid (5 s) actions of a series of iodothyronines on muscimol-stimulated uptake of (36)cl(-) were investigated in synaptoneurosomes prepared from rat brain. the results were correlated with molecular modeling of the active compounds. dose-response curves for muscimol in the presence of 3,3', 5-l-triiodothyronine (l-t3) indicated a noncompetitive inhibition of muscimol-stimulated (36)c ... | 2004 | 15033424 |
| increased aberrance of cytokine expression in plasma of patients with more advanced squamous cell carcinoma of the head and neck. | patients with head and neck squamous cell carcinoma (hnscc) are biased toward the th2 phenotype as they have increased levels of the th2 cytokines il-4, il-6 and il-10 and diminished levels of the th1 cytokine ifn-gamma. however, this bias is incomplete since levels of the th1 cytokines il-2 and gm-csf are increased. this study examined the interrelationship among the plasma levels of th1 and th2 cytokines in 101 hnscc patients and 40 age-matched controls without a known malignancy. control subj ... | 2004 | 15036248 |
| induction of a new follicular wave in holstein heifers synchronized with norgestomet. | treatments with progestin to synchronize the bovine estrous cycle in the absence of the corpus luteum, induces persistence of a dominant follicle and a reduction of fertility at doses commonly utilized. the objective of the present research was to induce a new wave of ovarian follicular development in heifers in which stage of the estrous cycle was synchronized with norgestomet. holstein heifers (n=30) were used, in which estrus was synchronized using two doses of pgf2alpha i.m. (25 mg each) 11 ... | 2004 | 15036514 |
| prognosis of muscle-invasive bladder cancer: difference between primary and progressive tumours and implications for therapy. | to evaluate the difference in prognosis between progressive and primary muscle-invasive bladder cancer. | 2004 | 15036673 |
| in vitro development of preimplantation porcine nuclear transfer embryos cultured in different media and gas atmospheres. | this study investigated the effect of culture media and gas atmospheres on the development of porcine nuclear transfer embryos. oocytes derived from a local abattoir were matured for 42-44 h and enucleated. fetal fibroblasts were prepared from a day 35 porcine fetus. confluent stage fetal fibroblasts were introduced into the perivitelline space of enucleated oocytes. fusion and activation were induced simultaneously with two direct current (1.2 kv/cm for 30 micros) in 0.3 m mannitol medium. for ... | 2004 | 15037000 |
| inactivation of the 3'-5' exonuclease of the replicative t4 dna polymerase allows translesion dna synthesis at an abasic site. | here, we have investigated the consequences of the loss of proof-reading exonuclease function on the ability of the replicative t4 dna polymerase (gp43) to elongate past a single abasic site located on model dna substrates. our results show that wild-type t4 dna polymerase stopped at the base preceding the lesion on two linear substrates having different sequences, whereas the gp43 d219a exonuclease-deficient mutant was capable of efficient bypass when replicating the same substrates. the struct ... | 2004 | 15037066 |
| surgery for t4 non-small cell lung cancer. | | 2004 | 15037295 |
| the neurospora crassa cyt-18 protein c-terminal rna-binding domain helps stabilize interdomain tertiary interactions in group i introns. | the neurospora crassa mitochondrial tyrosyl-trna synthetase (cyt-18 protein) promotes the splicing of group i introns by stabilizing the catalytically active rna structure. to accomplish this, cyt-18 recognizes conserved structural features of group i intron rnas using regions of the n-terminal nucleotide-binding fold, intermediate alpha-helical, and c-terminal rna-binding domains that also function in binding trna(tyr). curiously, whereas the splicing of the n. crassa mitochondrial large subuni ... | 2004 | 15037773 |
| practical and general synthesis of 5'-adenylated rna (5'-apprna). | a simple strategy is reported for 5'-adenylation of nearly any rna sequence of indefinite length. the 5'-adenylated product (5'-apprna) is an activated rna that is structurally similar to 5'-triphosphorylated rna, which is usually prepared by in vitro transcription using t7 rna polymerase. in the new 5'-adenylation strategy, the rna substrate is first 5'-monophosphorylated either by t4 polynucleotide kinase, by in vitro transcription in the presence of excess gmp, or by appropriate derivatizatio ... | 2004 | 15037782 |
| generation of optimized yellow and red fluorescent proteins with distinct subcellular localization. | fluorescent proteins (fps) have revolutionized many aspects of cell biology and have become indispensable research tools. today's increasingly complex experiments aiming to understand biological systems strongly depend on the availability of combinations of multiple fps, which allow their distinguishable simultaneous detection in the same cell or tissue. recently, the venus and dsred. t4 fps were described as the latest generation of yellow and red fps. to increase the combinatorial possibilitie ... | 2004 | 15038157 |
| new drosophila transgenic reporters: insulated p-element vectors expressing fast-maturing rfp. | in vivo green fluorescent protein (gfp)/red fluorescent protein (rfp) double-labeling studies have been hampered by several inconvenient properties of dsred, the first described rfp. these disadvantages include a very slow (> 24 h) maturation time, emission of contaminating green light, and low solubility. a recently developed variant of dsred, called dsred.t4, has a much shorter maturation time, no significant green emission, and improved solubility. we have constructed drosophila p-element tra ... | 2004 | 15038159 |
| [adenoid cystic carcinoma of the head and neck: a review of 30 cases]. | to evaluate treatment results and identify prognostics factors which determine local and regional treatment failure and crude survival in adenoid cystic tumours (act) in the head and neck. | 2003 | 15038566 |
| [effects of 7-oxo-dhea treatment on the immunoreactivity of balb/c mice subjected to chronic mild stress]. | to determine whether 7-oxo-dehydroepiandrosterone (7-oxo-dhea) can reverse the hypoimmunity in balb/c mice exposed to chronic mild stress. | 2003 | 15040075 |
| [tracheoesophageal shunt for voice reconstruction after total laryngectomy to prevent from deglutition disorders]. | to observe the effect of tracheoesophageal shunt on voice reconstruction after total laryngectomy. | 2003 | 15040105 |
| thyroid hormone levels in patients with aortic dissection: comparison with controls and correlation with the percentage of the aortic media composed of myxoid deposits. | deposits of myxoid material, similar to myxedema related to thyroid disease, are described in the medial layer of aortas with dissection. we analyzed the clinical or subclinical thyroid dysfunction of patients with this disease and analyzed whether a correlation exists between serum levels of thyroid-related hormones and the myxoid content of the aortic media. | 2004 | 15042249 |
| changes of hypothalamus-pituitary hormones in patients after total removal of craniopharyngiomas. | this paper aimed to elucidate the changes of hypothalamus-pituitary hormones in patients after total removal of craniopharyngiomas. | 2004 | 15043773 |
| molecular cloning and characterization of beta1,4-n-acetylgalactosaminyltransferases iv synthesizing n,n'-diacetyllactosediamine. | a sequence highly homologous to beta1,4-n-acetylgalactosaminyltransferase iii (beta4galnac-t3) was found in a database of human expressed sequence tags. the full-length open reading frame of the gene, beta4galnac-t4 (genbank accession number ab089939), was cloned using the 5' rapid amplification of cdna ends method. it encodes a typical type ii transmembrane protein of 1039 amino acids having 42.6% identity with beta4galnac-t3. the recombinant enzyme transferred n-acetylgalactosamine to n-acetyl ... | 2004 | 15044014 |
| [interdiscplinarity in thorax operations-from the viewpoint of the surgeon]. | occasionally, thoracic interventions may require interdisciplinary teamwork with plastic surgery, heart and vascular surgery, or neurosurgery. thoracic wall defects following excision of primary wall tumors or recurrent, ulcerating tumors of the breast may require full-thickness myocutaneous flaps, which can best be done with the help of plastic surgeons. in case of infiltration of the heart or thoracic aorta, the en bloc principle of t4 lung tumors occasionally requires the help of heart surgeo ... | 2004 | 15045203 |
| [evaluation of the osteoinductive potential of genetically modified bmp-2 variants]. | the alteration of the n-terminal amino acid sequence of bmp-2 allows modification of heparin binding of the new protein. this leads to a change in the local retention time at the site of implantation. mutants with increased (t3, t4) and with no binding (ehbmp-2) to heparin were assessed for their osteoinductivity in vivo and compared with the wild type bmp-2. | 2004 | 15045531 |
| [a case of inoperable advanced gallbladder cancer that has maintained stable disease status for a long period with gemcitabine and cisplatin therapy]. | we report a case of inoperable advanced gallbladder cancer that responded to treatment with gemcitabine (gem) and cisplatin (cddp) therapy. a 54-year-old woman was diagnosed in a nearby hospital with inoperable advanced gallbladder cancer (t4, n1, h0, p1, m(-): stage iv b) with direct invasion to the liver. therefore, chemotherapy was performed by ts-1. two months later, however, the disease was found to have progressed, and she was referred to our hospital for further therapy. combined chemothe ... | 2004 | 15045958 |
| bioaccumulation, biotransformation, and biochemical effects of brominated diphenyl ethers in juvenile lake trout (salvelinus namaycush). | juvenile lake trout (salvelinus namaycush) were exposed to three dietary concentrations (0, approximately 2.5, and approximately 25 ng/g per bde congener) of 13 bde congeners (3-10 br atoms) in the laboratory for 56 days, followed by 112 days of clean food, to examine bioaccumulation parameters and potential biochemical effects. the bioaccumulation of bdes by the trout was highly influenced by biotransformation, via debromination, which resulted in bioaccumulation parameters that were much diffe ... | 2004 | 15046352 |
| oromandibular reconstruction with simultaneous free flaps: experience on 10 cases. | composite defects resulting from surgery for advanced oral cancer represent a difficult reconstructive problem and, in some cases, tissutal defects are extensive requiring multiple free flaps. personal experience is reported with double free-flap technique in the reconstruction of large complex defects in 10 patients treated for t4 oral squamous-cell carcinoma. fibula osteo-cutaneous free flap was used in association with forearm free flap in 5 cases, fibula osseous-forearm in 3 cases, fibula os ... | 2003 | 15046417 |
| oligonucleotide ligation assay-based dna chip for multiplex detection of single nucleotide polymorphism. | an oligonucleotide ligation assay-based dna chip has been developed to detect single nucleotide polymorphism. synthesized nonamers, complementary to the flanking sequences of the mutation sites in target dna, were immobilized onto glass slides through disulfide bonds on their 5' terminus. allele-specific pentamers annealed adjacent to the nonamers on the complementary target dna, containing 5'-phosphate groups and biotin labeled 3'-ends, were mixed with the target dna in tube. ligation reactions ... | 2004 | 15046760 |
| investigation of the effects of patulin on thyroid and testis, and hormone levels in growing male rats. | patulin is a mycotoxin produced by several species of penicillium, aspergillus and byssachlamys. patulin can be produced on different food products including fruits, grains, cheese, cured meats, but in natural situations patulin is usually found in apple and apple products. in the present study, the time-dependent effects of patulin on the t3, t4, thyroid stimulating hormone, testosterone, luteinizing hormone and growth hormone levels of growing male rats were investigated. patulin, at a dose of ... | 2004 | 15046817 |
| testing a flexible-receptor docking algorithm in a model binding site. | sampling receptor flexibility is challenging for database docking. we consider a method that treats multiple flexible regions of the binding site independently, recombining them to generate different discrete conformations. this algorithm scales linearly rather than exponentially with the receptor's degrees of freedom. the method was first evaluated for its ability to identify known ligands of a hydrophobic cavity mutant of t4 lysozyme (l99a). some 200000 molecules of the available chemical dire ... | 2004 | 15046985 |
| comparison of embryo physiological parameters during incubation, chick quality, and growth performance of three lines of broiler breeders differing in genetic composition and growth rate. | in broiler breeder management, stringent feed restriction is practiced to reduce body size in order to improve egg production and meet broiler production demand, but this practice has raised welfare issues. the potential for the dwarfing (dw) gene to reduce feed intake and body size of breeders under ad libitum feeding or less stringent restriction while maintaining improved egg production has been reported. in this study, we compared embryo physiology, quality of chicks, and performance of broi ... | 2004 | 15049506 |
| pre-steady-state kinetics of rb69 dna polymerase and its exo domain mutants: effect of ph and thiophosphoryl linkages on 3'-5' exonuclease activity. | dna polymerases from the a and b families with 3'-5' exonucleolytic activity have exonuclease domains with similar three-dimensional structures that require two divalent metal ions for catalysis. b family dna polymerases that are part of a replicase generally have a more potent 3'-5' exonuclease (exo) activity than a family dna polymerases that mainly function in dna repair. to investigate the basis for these differences, we determined ph-activity profiles for the exonuclease reactions of t4, rb ... | 2004 | 15049692 |
| cortisol abnormality as a cause of elevated estrogen and immune destabilization: insights for human medicine from a veterinary perspective. | for more than 35 years the author has treated multiple serious diseases in cats and dogs by correcting an unrecognized endocrine-immune imbalance originating with a deficiency or defect of cortisol. the cortisol abnormality creates a domino effect on feedback loops involving the hypothalamus-pituitary-adrenal axis. in this scenario, estrogen becomes elevated, thyroid hormone becomes bound, and b and t cells become deregulated. diseases with this aberration as a primary etiological component rang ... | 2004 | 15050110 |
| phase i study of 5-fluorouracil and leucovorin by continuous infusion chronotherapy and pelvic radiotherapy in patients with locally advanced or recurrent rectal cancer. | to determine the maximal tolerated dose of chronomodulated 5-fluorouracil (5-fu) and leucovorin (lv) given concurrently with radiotherapy in patients with rectal cancer. | 2004 | 15050328 |
| salvage radiotherapy for palpable, locally recurrent prostate cancer after radical prostatectomy. | a retrospective study to evaluate the outcome of salvage radiotherapy (rt) for clinically apparent, palpable prostate cancer recurrence after radical prostatectomy (rp). | 2004 | 15050333 |
| association between vitamin d receptor polymorphisms and prostate cancer risk in a taiwanese population. | recent molecular epidemiological studies have shown that the inherited polymorphisms of vdr gene may be linked to prostate cancer risk and its aggressive phenotypes. however, the findings remain inconclusive. in this study, we investigated the association of the bsmi, apai and taqi polymorphisms of vdr gene with prostate cancer risk in a taiwanese population. in total, 160 prostate cancer patients and 205 age-matched male controls were studied between december 2000 and february 2003. no signific ... | 2004 | 15050735 |
| dietary soy protein isolate and isoflavones modulate hepatic thyroid hormone receptors in rats. | thyroid hormone receptors (trs) are regulators of many genes involved in cholesterol and lipid metabolism. the purpose of this study was to examine the effect of soy protein isolate (spi) and isoflavones on hepatic trs in rats. in expt. 1, sprague-dawley rats were fed diets containing either casein or alcohol-washed spi with or without isoflavone supplementation (5-1250 mg/kg diet) for 70, 190, and 310 d. the offspring (f1) were fed the same diets as their parents (f0). in expt. 2, sprague-dawle ... | 2004 | 15051820 |
| can surgical diagnosis of "early" gastric cancer and lymph node metastasis be accurate? | the objective of this study was to evaluate the accuracy of the intraoperative assessment of early gastric cancer (egc) and lymph node status. | 2004 | 15052438 |
| slow growth of benign thyroid nodules after menopause: no need for long-term thyroxine suppressive therapy in post-menopausal women. | benign thyroid nodules represent a very common disorder, the management of which is still controversial. the aim of the present work was to evaluate by ultrasound examination the volume changes of thyroid nodules in post-menopausal women presenting single palpable nodular goiter of recent onset (less than 6 months from diagnosis). forty-three patients received l-t4-treatment, 38 represented the no-treatment group. long-term follow up (3 and 5 yr) did not show any significant change in the mean v ... | 2004 | 15053240 |
| left ventricular systolic and diastolic functions in children living in a moderate-severe iodine deficiency area. | although the effects of impaired thyroid functions on the cardiovascular system is well known, there is no report investigating left ventricular functions in children with iodine deficiency. we evaluated left ventricular functions in children living in a moderate-severe iodine deficient area of northern turkey. of 40 children, 13 had stage i, 19 had stage ii and eight had stage iii goiter. none of the children had clinical signs of hypothyroidism, hyperthyroidism or cardiac dysfunction. urinary ... | 2004 | 15055354 |
| circulating nitric oxide is modulated by recombinant human tsh administration during monitoring of thyroid cancer remnant. | during the administration of recombinant human tsh (rhtsh) to monitor differentiated thyroid carcinoma, mild side effects, such as nausea and headaches, often occur. the origin of these is not clear. since changes in tsh and thyroid hormones can modulate some endothelial-derived factors, we aimed at testing whether rhtsh administration induces changes in nitric oxide. we studied 25 patients (56.6+/-12.6 yr) who had undergone thyroidectomy followed by ablative radioiodine for papillary thyroid ca ... | 2003 | 15055471 |
| characterization of polynucleotide kinase/phosphatase enzymes from mycobacteriophages omega and cjw1 and vibriophage kvp40. | coliphage t4 pnkp is a bifunctional polynucleotide 5'-kinase/3'-phosphatase that catalyzes the end-healing steps of a rna repair pathway. here we show that mycobacteriophages omega and cjw1 and vibriophage kvp40 also encode bifunctional pnkp enzymes consisting of a proximal 5'-kinase module with an essential p-loop motif, gxgk(s/t), and a distal 3'-phosphatase module with an essential acyl-phosphatase motif, dx- dgt. biochemical characterization of the viral pnkp proteins reveals several shared ... | 2004 | 15056675 |
| [the relation between thyroid function and depression: a review]. | the role of the thyroid gland in primary depressive disorder is unclear. although there is evidence that patients with subtle underlying defects in thyroid function may be more prone to developing depressive disease, the specific abnormality in thyroid function associated with depressive disorders remains poorly understood. in this review, we outline the major findings concerning depression and thyroid function, with particular attention on the relationship between thyroid function and cerebral ... | 2004 | 15057840 |
| evolution of blood parameters during weight loss in experimental obese beagle dogs. | the effects of weight loss on hormonal and biochemical blood parameters were measured monthly [carnitine, creatinine, urea, free t4 (ft4), total t4 (tt4), plasma alkaline phosphatases (alp), aspartate aminotransferase (ast), alanine aminotransferase (alt), potassium and total proteins] or bimonthly [cholesterol, triglycerides, non-esterified fatty acids (nefa), insulin-like growth factor i (igf-i), glucose, insulin] in eight obese beagles dogs fed either a high protein dry diet, dp (crude protei ... | 2004 | 15059242 |