| small intestinal submucosa as a bioscaffold for tissue regeneration in defects of the colonic wall. | small intestinal submucosa (sis) has proved considerable regenerative capacity for repair of bowel wall defects at different locations. this study assesses the effectiveness of sis in the repair of defects at a gastrointestinal location with strong bacterial contamination. | 2009 | 18766420 |
| development of a swine model of secondary liver tumor from a genetically induced swine fibroblast cell line. | metastatic disease is the most common liver tumor. although alternative therapies have been developed for non-surgical candidates, those therapies lacked ideal testing prior to clinical application because of a paucity of large animal models. the purpose of the present study was to develop a model for secondary liver tumor in a large animal. | 2008 | 18773055 |
| development of two trichoplusia ni larvae-derived elisas for the detection of antibodies against replicase and capsid proteins of porcine circovirus type 2 in domestic pigs. | the main aim of the present study was to describe new methods for the identification of antibodies against the pcv2 capsid (cap) and replicase (rep) proteins in pig sera. specifically, two new indirect enzyme-linked immunosorbent assays (elisa) were developed based on recombinant pcv2 cap (rcap) and rep/rep' (rrep) proteins expressed in baculovirus and produced in trichoplusia ni insect larvae. both assays were validated by testing serum samples in a longitudinal study of 107 animals with differ ... | 2008 | 18773923 |
| natural orifice translumenal endoscopic surgery (notes) renal cryoablation in a porcine model. | to present our laboratory experience with natural orifice translumenal endoscopic surgery (notes) renal cryoablation. | 2008 | 18778358 |
| in vivo evaluation of anodic tio2 nanotubes: an experimental study in the pig. | because of their ability to mimic the dimensions of constituent components of natural bone and the possibility to serve as a gene and drug-delivery carrier, nanotubes seem to be a promising coating for medical implants. aim of this study was to investigate the effects of a tio(2) nanotube structured surface on periimplant bone formation in vivo when compared with an untreated standard titanium surface. twenty-five titanium implants covered with an ordered tio(2) nanotube layer with an individual ... | 2009 | 18780361 |
| vocal mother-offspring communication in guinea pigs: females adjust maternal responsiveness to litter size. | abstract: | 2008 | 18783602 |
| the proinflammatory cytokine response following resuscitation in the swine model depends on the method of ventricular fibrillation induction. | a systemic inflammatory response has been reported following resuscitation from cardiac arrest. the purpose of this study was to compare the magnitude of the tumor necrosis factor-alpha (tnf-alpha) response in two different swine models of ventricular fibrillation (vf) arrest. | 2008 | 18785945 |
| identification and sequencing of remnant messenger rnas found in domestic swine (sus scrofa) fresh ejaculated spermatozoa. | the existence of specific messenger rna remnants contained within freshly ejaculated spermatozoa was described in several species. those investigations, using high-throughput techniques to screen the population of transcripts in ejaculated spermatozoa, were limited to the probes which mostly derived from nucleic acids of testicular tissues of either human or mice. the objective of this study was to investigate mrna remnants from ejaculated spermatozoa of the domestic swine (sus scrofa), a valuab ... | 2009 | 18786788 |
| sleep-induced hypotension precipitates severe myocardial ischemia. | epidemiologic studies have shown a high frequency of major cardiac events at night in patients with coronary artery disease. this has been attributed to the sympathetic surges accompanying rapid eye movement (rem) sleep; the role of non-rem sleep, which comprises 80% of total sleep duration, has been largely neglected. accordingly, we evaluated the effect of non-rem sleep on contractile function in a region of the left ventricular wall supplied by a flow-limiting coronary stenosis. | 2008 | 18788646 |
| isolation and cloning of two variant papillomaviruses from domestic pigs: sus scrofa papillomaviruses type 1 variants a and b. | the healthy skin of two female domestic pigs (sus scrofa domestica) was sampled with cotton-tipped swabs. total genomic dna was extracted from the samples and subjected to pcr with degenerate papillomavirus (pv)-specific primers. similarity searches performed with blastn showed that partial e1 and l1 sequences of two novel pvs were amplified. subsequently, the complete genomes of these sus scrofa papillomaviruses (sspvs) were amplified by long-template pcr, cloned and sequenced using a transposo ... | 2008 | 18796716 |
| intravenous tezosentan and vardenafil attenuate acute hypoxic pulmonary hypertension. | excessive hypoxic pulmonary hypertension imposes right ventricular strain by increasing afterload that may lead to right heart failure and death. increased phosphodiesterase activity, as well as increased levels of endothelin-1, has been discussed as molecular mechanisms. we investigated the hemodynamic and intrapulmonary effects of the intravenous dual endothelin a and b receptor blocker tezosentan, and of the phosphodiesterase-5 (pde-5) antagonist vardenafil in a pig model of acute normobaric ... | 2008 | 18800959 |
| finite element representation of bone substitute remodelling in the jaw bone. | the finite element (fe) method was originally developed on a physical basis for the computation of structure-mechanical problems. meanwhile, it has been widely applied to medical issues. this study sought a suitable method to build a fe model for remodelling processes in osseous defects supplemented with bone substitute material. for this purpose, the second right premolars were extracted from four pig mandibles (sus scrofa domesticus) and the extraction alveoli were provided with synthetic bone ... | 2008 | 18803527 |
| the use of composite meshes in laparoscopic repair of abdominal wall hernias: are there differences in biocompatibily?: experimental results obtained in a laparoscopic porcine model. | in recent years, laparoscopic repair of abdominal wall hernias has become increasingly established in routine clinical practice thanks to the myriad advantages it confers. apart from the risk of intestinal damage following adhesiolysis, to date no information is available on the best way of preventing the formation of new adhesions in the vicinity of the implanted meshes. numerous experimental investigations, mainly conducted on an open small-animal model, have demonstrated the advantages of coa ... | 2009 | 18806942 |
| restenosis is not associated with stent length in a pig model of coronary stent implantation. | the aim of this study was to determine if stent length is by itself a risk factor for intimal proliferation and restenosis. long lesions represent an independent risk factor for restenosis after coronary stent implantation. a longer stented segment might result in a higher probability of restenosis. | 2008 | 18810722 |
| the effect of continuous release of recombinant human epidermal growth factor (rh-egf) in chitosan film on full thickness excisional porcine wounds. | the purpose of this article is to evaluate the effect of continuously released recombinant human epidermal growth factor (rh-egf) in chitosan film in full thickness porcine wounds. a total of 10 domestic pigs (yorkshire species) weighing 18 to 22 kg between the ages of 50 to 60 days were used. the wounds were divided into 3 groups and treated selectively with rh-egf in chitosan film (egf 20 ug/wound/d), chitosan film without rh-egf, or remained as the control group. one hundred percent healing t ... | 2008 | 18812721 |
| detection of brachyspira hyodysenteriae, lawsonia intracellularis and brachyspira pilosicoli in feral pigs. | feral pigs are recognized as being a potential reservoir of pathogenic microorganisms that can infect domestic pigs and other species. the aim of this study was to investigate whether feral pigs in western australia were colonized by the pathogenic enteric bacteria lawsonia intracellularis, brachyspira hyodysenteriae and/or brachyspira pilosicoli. a total of 222 feral pigs from three study-populations were sampled. dna was extracted from faeces or colonic contents and subjected to a previously d ... | 2009 | 18818030 |
| minimal interruption of cardiopulmonary resuscitation for a single shock as mandated by automated external defibrillations does not compromise outcomes in a porcine model of cardiac arrest and resuscitation. | current automated external defibrillations require interruptions in chest compressions to avoid artifacts during electrocardiographic analyses and to minimize the risk of accidental delivery of an electric shock to the rescuer. the earlier three-shock algorithm, with prolonged interruptions of chest compressions, compromised outcomes and increased severity of postresuscitation myocardial dysfunction. in the present study, we investigated the effect of timing of minimal automated external defibri ... | 2008 | 18824916 |
| endothelin-1 is not predictive of ventricular ectopy or ventricular fibrillation during acute myocardial ischemia. | endothelin(et)-1 (et-1) increases after myocardial infarction and may have effects on myocardial function. et-1 has also been shown to affect the action potential (ap) which may be arrhythmogenic and predispose to ventricular fibrillation (vf). the effects of et-2 and et-3 are uncertain. we hypothesized that the ets increase during acute ischemia and that plasma levels are predictive of ischemically induced vf. thirty-four domestic swine underwent balloon occlusion of the proximal lad coronary a ... | 2008 | 18844577 |
| spatial distribution of taenia solium porcine cysticercosis within a rural area of mexico. | cysticercosis is caused by taenia solium, a parasitic disease that affects humans and rurally bred pigs in developing countries. the cysticercus may localize in the central nervous system of the human, causing neurocysticercosis, the most severe and frequent form of the disease. there appears to be an association between the prevalence of porcine cysticercosis and domestic pigs that wander freely and have access to human feces. in order to assess whether the risk of cysticercosis infection is cl ... | 2008 | 18846230 |
| changes in spatial collagen content and collagen network architecture in porcine articular cartilage during growth and maturation. | the present study was designed to reveal changes in the collagen network architecture and collagen content in cartilage during growth and maturation of pigs. | 2009 | 18849174 |
| current world status of balantidium coli. | balantidium coli is a cosmopolitan parasitic-opportunistic pathogen that can be found throughout the world. pigs are its reservoir hosts, and humans become infected through direct or indirect contact with pigs. in rural areas and in some developing countries where pig and human fecal matter contaminates the water supply, there is a greater likelihood that balantidiosis may develop in humans. the infection may be subclinical in humans, as it mostly is in pigs, or may develop as a fulminant infect ... | 2008 | 18854484 |
| the trypanocidal effects of dimidium bromide (phenanthridinium 1553) on trypanosoma simiae in domestic pigs. | | 1948 | 18891584 |
| optical coherence tomography and intravascular ultrasound imaging of bioabsorbable magnesium stent degradation in porcine coronary arteries. | absorbable metallic stents (ams) composed of magnesium alloy were designed to complete degradation within 90-120 days. among the potential advantages of these stents, when compared to conventional stents, are the elimination of late stent thrombosis, chronic inflammation, and artifacts during noninvasive imaging. | 2008 | 18928950 |
| continuous hemofiltration in pigs with hyperdynamic septic shock affects cardiac repolarization. | sepsis has been defined as the systemic host response to infection with an overwhelming systemic production of both proinflammatory and anti-inflammatory mediators. continuous hemofiltration has been suggested as possible therapeutic option that may remove the inflammatory mediators. however, hemodialysis and hemofiltration were reported to influence cardiac electrophysiologic parameters and to increase the arrhythmogenic risk. we hypothesize that sepsis affects electrophysiologic properties of ... | 2008 | 18936693 |
| purification, molecular cloning, heterologous expression and characterization of pig cyp1a2. | porcine cytochrome p450 (cyp) 1a2 was purified to electrophoretic homogeneity from the hepatic microsomes of beta-naphthoflavone-treated male pigs. in a reconstituted system, this enzyme showed a good catalytic activity towards caffeine, acetanilide, and methoxyresorufin, all known markers of mammalian cyp1a2. using 3'- and 5'-rapid amplification of coding dna (cdna) ends (race), we amplified from the liver rna of control pigs a full-length 1827 bp cdna containing an open reading frame of 1548 b ... | 2008 | 18949657 |
| effects of pre-arrest and intra-arrest hypothermia on ventricular fibrillation and resuscitation. | hypothermia has been shown to improve survival and neurological outcomes for ventricular fibrillation (vf) cardiac arrest. the electrophysiological mechanisms of hypothermia are not well-understood, nor are the effects of beginning cooling during the resuscitation. | 2009 | 18952346 |
| isolation and characterization of perv-c env from domestic pig in korea. | clone perv-c (a3) env was isolated from the genomic dna of domestic pig (sus scrofa domesticus) in korea to investigate the molecular properties of perv-c. the nucleic acid homologies between the perv-msl (type c) reference and the perv-c(a3) clone was 99% for env, but a single base pair deletion was found in the transmembrane (tm) region of the env open reading frame. to examine the functional characteristics of truncated perv-c env, we constructed a replication-incompetent retroviral vector by ... | 2008 | 18955828 |
| detection and genetic characterization of porcine circovirus 2 isolates from the first cases of postweaning multisystemic and wasting syndrome in wild boars in greece. | in 2002, postweaning multisystemic wasting syndrome (pmws) was diagnosed in a european female wild boar (sus scrofa), based on the detection of porcine circovirus 2 (pcv2) dna in various organs, including the uterus, and on histopathologic lesions. this is the first detection of pcv2 dna in the uterus of a wild boar. three years later (2005), a wild boar < 6-8 mo of age was found moribund. it presented wasting and dyspnea and finally died. pcv2 dna was detected in tissue samples, and histopathol ... | 2008 | 18957642 |
| domestic pigs and japanese encephalitis virus infection, australia. | to determine whether relocating domestic pigs, the amplifying host of japanese encephalitis virus (jev), decreased the risk for jev transmission to humans in northern australia, we collected mosquitoes for virus detection. detection of jev in mosquitoes after pig relocation indicates that pig relocation did not eliminate jev risk. | 2008 | 18976557 |
| [experimental study on a new method for colonoscopic closure of large-bowel perforations with the otsc clip]. | iatrogenic perforation of the colon during interventional endoscopic procedures, e.g., mucosectomy, is a problematic complication, as safe treatment often requires surgical repair. iatrogenic perforation of the colon is indeed a rare complication; however, given the increasing case numbers in interventional endoscopy it is of considerable practical relevance. the closure of perforations can be achieved with conventional endoscopic clips; however, these working channel based clips are often too s ... | 2008 | 18979620 |
| the environmental and public health risks associated with arsenical use in animal feeds. | arsenic exposures contribute significantly to the burden of preventable disease worldwide, specifically related to increased risks of cancer, diabetes, and cardiovascular disease. most exposures are associated with natural contamination of groundwater, which is difficult to mitigate when these sources are used for drinking water. an anthropogenic source of arsenic exposure stems from the widespread use of arsenical drugs in food-animal production in the united states and china, among many countr ... | 2008 | 18991934 |
| platelets from diabetic pigs exhibit hypersensitivity to thrombin. | responses of platelets from diabetic and diabetic-hyperlipidemic pigs were studied. pigs were made diabetic with single dose of alloxan, which acts by selectively destroying insulin-producing pancreatic beta cells thus inducing type 1 diabetes. pigs were kept for 1 or 12 wk, during which thrombin-induced aggregation was monitored in washed platelets. the platelets showed increased sensitivity to aggregation within 1 wk of induction of diabetes. hyperlipidemia alone for 12 wk did not increase pla ... | 2008 | 19004374 |
| enhanced discrimination of african swine fever virus isolates through nucleotide sequencing of the p54, p72, and pb602l (cvr) genes. | complete sequencing of p54-gene from 67 european, american, and west and east african swine fever virus (asfv) isolates revealed that west african and european asfv isolates classified within the predominant genotype i according to partial sequencing of p72 were discriminated into four major sub-types on the basis of their p54 sequences. this highlighted the value of p54 gene sequencing as an additional, intermediate-resolution, molecular epidemiological tool for typing of asfv viruses. we furth ... | 2009 | 19009341 |
| comparative study of in vivo lymphatic sealing capability of the porcine thoracic duct using laparoscopic dissection devices. | sealing the lymphatic vessels during abdominal and pelvic surgery is important to prevent the leakage of lymphatic fluid and its resultant sequelae. to our knowledge we compared for the first time the quality of lymphatic sealing by each of 4 commonly used laparoscopic dissection devices. | 2009 | 19010491 |
| expression, cellular localization and antibody responses of the african swine fever virus genes b602l and k205r. | previously, we identified serological immunodeterminants of african swine fever virus (asfv), including pk205r and pb602l, without homologues in the database. pk205r is expressed as a 33-kd protein from 4 h post-infection onward, initially diffusely distributed throughout cells, and subsequently in viral factories. pk205r was not found in purified virus. both pk205r and pb602l are recognised by hyperimmune antisera from domestic pigs and bushpigs at late time points after infection, suggesting t ... | 2008 | 19011730 |
| transvenous intramyocardial cellular delivery increases retention in comparison to intracoronary delivery in a porcine model of acute myocardial infarction. | clinical trials using intracoronary (ic) delivery of cells have addressed efficacy but the optimal delivery technique is unknown. our study aimed to determine whether transvenous intramyocardial (tvim) approach was advantageous for cellular retention in ami. | 2008 | 19012733 |
| pig and guinea pig skin as surrogates for human in vitro penetration studies: a quantitative review. | both human and animal skin in vitro models are used to predict percutaneous penetration in humans. the objective of this review is a quantitative comparison of permeability and lag time measurements between human and animal skin, including an evaluation of the intra and inter species variability. we limit our focus to domestic pig and rodent guinea pig skin as surrogates for human skin, and consider only studies in which both animal and human penetration of a given chemical were measured jointly ... | 2009 | 19013230 |
| diffuse spectral fundus reflectance measured using subretinally placed spectralon. | the diffuse fundus reflectance and the spectral transmittance of the swine sensory retina was measured in vivo using intravitreal illumination. pars plana vitrectomy and intravitreal manipulations were performed on a female american yorkshire domestic swine. light from a scanning monochromator was coupled into a fiber optic intraocular illuminator inserted into the vitreous. a 1.93-mm(2) region of the illuminated fundus was imaged from an oblique illumination angle. multispectral retinal images ... | 2008 | 19021332 |
| occurrence of moniezia expansa (rud, 1810) blanchard, 1891 (cestoda: anoplocephalidae) in domestic pig (sus scrofa domestica linnaeus, 1758) in perú. | the presence of moniezia expansa (rud, 1810) blanchard, 1891, is reported in domestic pig (sus scrofa domestica linnaeus, 1758). four tapeworms were collected and identified as m. expansa. this is the first report of m. expansa collected in a domestic pig in perú. | 2008 | 19028016 |
| ivabradine induces an increase in ventricular fibrillation threshold during acute myocardial ischemia: an experimental study. | tachycardia often facilitates ischemic ventricular fibrillation (vf). | 2008 | 19034029 |
| species identification of trichinella isolates from china. | two species of trichinella were identified from china by means of pcr amplification of the mitochondrial small subunit ribosomal dna and the expansion segment v region of the ribosomal dna. seven isolates originating from domestic pig and one isolate originating from dog showed identical dna banding pattern to trichinella spiralis, and two isolates from dog showed dna banding pattern identical to trichinella nativa. sequence analysis of the 5s rdna inter-gene spacer region from the ten trichinel ... | 2009 | 19036522 |
| pilot study evaluating ureteric physiological changes with a novel 'ribbon stent' design using electromyographic and giant magnetoresistive sensors. | to test a novel 'ribbon stent' (rs) design using an extraluminal bipolar electromyographic (emg) and giant magnetoresistive (gmr) sensor system to characterize ureteric responses. | 2009 | 19040534 |
| the birth of a trichinella britovi focus on the mediterranean island of sardinia (italy). | for 60 years, the islands of the mediterranean basin were considered to be trichinella-free. in april 2005, an outbreak of human trichinellosis due to the consumption of infected pork involved 11 persons in the villages of orgosolo and lanusei (nuoro province) on the island of sardinia (italy). we conducted an investigation to identify free-range and backyard pigs and other humans with trichinella infection in the area of the 2005 outbreak. we also tested wild animals from various parts of sardi ... | 2009 | 19041178 |
| probing of actinobacillus pleuropneumoniae apxiiia toxin-dependent cytotoxicity towards mammalian peripheral blood mononucleated cells. | abstract: | 2008 | 19046441 |
| african swine fever virus isolate, georgia, 2007. | african swine fever (asf) is widespread in africa but is rarely introduced to other continents. in june 2007, asf was confirmed in the caucasus region of georgia, and it has since spread to neighboring countries. dna fragments amplified from the genome of the isolates from domestic pigs in georgia in 2007 were sequenced and compared with other asf virus (asfv) isolates to establish the genotype of the virus. sequences were obtained from 4 genome regions, including part of the gene b646l that enc ... | 2008 | 19046509 |
| candidate new species of kobuvirus in porcine hosts. | | 2008 | 19046542 |
| desferrioxamine attenuates minor lung injury following surgical acute liver failure. | acute liver failure (alf) can be complicated by lung dysfunction. the aim of this study was to test the hypothesis that inhibition of oxidative stress through iron chelation with desferrioxamine (dfx) attenuates pulmonary injury caused by alf. 14 adult female domestic pigs were subjected to surgical devascularisation of the liver and were randomised to a study group (dfx group, n = 7), which received post-operative intravenous infusion of dfx (14.5 mg x kg(-1) x h(-1) for the first 6 h post-oper ... | 2009 | 19047311 |
| inhibition of complement and cd14 attenuates the escherichia coli-induced inflammatory response in porcine whole blood. | the innate immune response is a double-edged sword in systemic inflammation and sepsis. uncontrolled or inappropriate activation can damage and be lethal to the host. several studies have investigated inhibition of downstream mediators, including tumor necrosis factor alpha (tnf-alpha) and interleukin-1beta (il-1beta). emerging evidence indicates that upstream inhibition is a better therapeutic approach for attenuating damaging immune activation. therefore, we investigated inhibition of two cent ... | 2009 | 19047409 |
| trichinella pseudospiralis in pig from croatia. | trichinella spiralis and trichinella britovi are species that are frequently found in domestic pigs and various sylvatic animals in croatia. during routine trichinoscopy, non-encapsulated larvae were detected in the muscle tissue of a domestic pig. artificial digestion revealed a larvae burden of 602 muscle larvae per gram of tissue. tissue section analysis confirmed the presence of non-encapsulated larvae. multiplex pcr identified the larvae as t. pseudospiralis. this observation is consistent ... | 2009 | 19054619 |
| isolation and characterization of intestinal escherichia coli clones from wild boars in germany. | our understanding of the composition of escherichia coli populations in wild boars is very limited. in order to obtain insight into the e. coli microflora of wild boars, we studied e. coli isolates from the jejunums, ileums, and colons of 21 wild boars hunted in five geographic locations in germany. ten isolates per section were subjected to clonal determination using pulsed-field gel electrophoresis. one representative isolate per clone was further investigated for virulence traits, phylogeneti ... | 2009 | 19060173 |
| trichinella spp. infection in horses of romania: serological and parasitological survey. | herbivorous animals are usually, by virtue of their diet, outside the major transmission cycles of trichinella spp. however, since 1975, the year of the first report of human trichinellosis caused by the consumption of infected horse meat, the domestic horse has appeared as a novel vector of trichinella spp. infection to humans, with 15 outbreaks documented in france and italy. romania, one of the main countries exporting horses into the european union (eu), experienced a dramatic increase of tr ... | 2009 | 19062194 |
| evaluation of shape and size changes of bone and remodelled bone substitute after different fixation methods. | suitable tissue fixation is indispensable to histological analysis. this investigation, therefore, sought to evaluate changes of shape and size of bone specimens and remodelled bone substitute material following different fixation methods. mandibular bones of 9 pigs (sus scrofa domesticus) served as specimens. two mandibular premolars were extracted respectively and the extraction alveoli were filled with synthetic bone substitute material. the samples were collected after 70 days. fixation of 6 ... | 2008 | 19075329 |
| soft tissue integration in the neck area of titanium implants--an animal trial. | dental implant materials are required to enable good apposition of bone and soft tissues. they must show sufficient resistance to chemical, physical and biological stress in the oral cavity to achieve good long-term outcomes. a critical issue is the apposition of the soft tissues, as they have provided a quasi-physiological closure of oral cavity. the present experiment was performed to study the peri-implant tissue response to non-submerged (1-stage) implant installation procedures. two differe ... | 2008 | 19075332 |
| the house fly (musca domestica) as a potential vector of metazoan parasites caught in a pig-pen in germany. | in the present study a total of 224 specimens of the synanthropic house fly (musca domestica) were caught in a pig-pen of an organic farmer in dormagen (germany). the flies were examined for their potential as a carrier of metazoan parasites. on the exoskeletons and in the intestines of the flies the eggs and/or larvae of four endoparasite nematode species of domestic pigs (ascaris suum, strongyloides ransomi, metastrongylus sp., undetermined strongylida) were isolated. also one ectoparasite spe ... | 2009 | 19081196 |
| importance of the porcine adam3 disintegrin domain in sperm-egg interaction. | in the mouse, adam3, a well-characterized testis-specific protein of the a disintegrin and metalloprotease (adam) family, has a crucial role in fertilization by mediating sperm binding to the egg zona pellucida. however, little is known about adam3 in other species, such as domestic pigs. we have identified porcine adam3 and analyzed the protein. rt-pcr and trypsinization of sperm surface proteins revealed that porcine adam3 is expressed at high levels in the testis and on the sperm surface. fur ... | 2009 | 19106482 |
| ectopic ventricular rhythms and myocardial infarction in the domestic pig and their response to nialamide, a monoamine oxidase inhibitor. | the development in indian domestic pigs of ectopic ventricular rhythms and a low-frequency tachycardia after the two-stage ligature of the anterior descending branch of the left coronary artery is described. when the ligature was tied 26+/-3 mm from the left auricular margin, the change in rhythm developed after 2 to 2.5 hr, reached a maximum after 6 hr and persisted up to 28 hr. the histopathological character of the resultant acute myocardial infarction is presented. in all, 52 pigs were used. ... | 1962 | 19108169 |
| spontaneous cardiac arrhythmias recorded in three experimentally- and drug-naive laboratory species (canine, primate, swine) during standard pre-study screening. | the purpose of this study was to collect and estimate the general prevalence of spontaneous irregularities in cardiac rhythms in three standard laboratory animal species: beagle dog (n=2450), cynomolgus monkey (n=1563), and domestic swine (n=704) during standard preclinical screening. | 2009 | 19111938 |
| first magnetic resonance imaging-guided aortic stenting and cava filter placement using a polyetheretherketone-based magnetic resonance imaging-compatible guidewire in swine: proof of concept. | the purpose of this study was to demonstrate feasibility of percutaneous transluminal aortic stenting and cava filter placement under magnetic resonance imaging (mri) guidance exclusively using a polyetheretherketone (peek)-based mri-compatible guidewire. percutaneous transluminal aortic stenting and cava filter placement were performed in 3 domestic swine. procedures were performed under mri-guidance in an open-bore 1.5-t scanner. the applied 0.035-inch guidewire has a peek core reinforced by f ... | 2009 | 19115070 |
| validation of a western blot for the detection of anti-trichinella spp. antibodies in domestic pigs. | trichinellosis is a zoonotic disease in humans caused by trichinella spp. according to international regulations and guidelines, serological surveillance can be used to demonstrate the absence of trichinella spp. in a defined domestic pig population. most enzyme-linked immunosorbent assay (elisa) tests presently available do not yield 100% specificity, and therefore, a complementary test is needed to confirm the diagnosis of any initial elisa seropositivity. the goal of the present study was to ... | 2009 | 19130084 |
| porcine reproductive and respiratory syndrome virus (prrsv) infection in wild boars. | the porcine reproductive and respiratory syndrome (prrs) is one of the economically most important swine diseases worldwide. the virus can be spread by viraemic and persistent infected pigs. spread and infection are advanced in areas with high herd and population densities. as wild boars have been found seropositive for prrsv in germany, france, and the usa, exchange between wild and domestic pig populations may exist. however, comprehensive information on prrsv infection in wild boars is presen ... | 2009 | 19131188 |
| drug-eluting balloon: very short-term exposure and overlapping. | paclitaxel balloon coating has shown promising effects in inhibiting restenosis in initial clinical trials. the aim of the present study was to evaluate the influence of two critical features of drug-eluting balloon (deb) application - inflation time and increased dose due to overlapping balloons. fifty-six stainless steel stents were implanted in the left anterior descending and circumflex coronary arteries of 28 domestic pigs using a 1.2:1.0 overstretch ratio. stents were mounted on convention ... | 2009 | 19132209 |
| epidemiology, diagnosis, treatment, and control of trichinellosis. | summary: throughout much of the world, trichinella spp. are found to be the causative agents of human trichinellosis, a disease that not only is a public health hazard by affecting human patients but also represents an economic problem in porcine animal production and food safety. due to the predominantly zoonotic importance of infection, the main efforts in many countries have focused on the control of trichinella or the elimination of trichinella from the food chain. the most important source ... | 2009 | 19136437 |
| diversification of porcine mhc class ii genes: evidence for selective advantage. | the major histocompatibility complex (mhc) is an immunological gene-dense region of high diversity in mammalian species. sus scrofa was domesticated by at least six independent events over eurasia during the holocene period. it has been hypothesized that the level and distribution of mhc variation in pig populations reflect genetic selection and environmental influences. in an effort to define the complexity of mhc polymorphisms and the role of selection in the generation of class ii gene divers ... | 2009 | 19142631 |
| contrasting mode of evolution at a coat color locus in wild and domestic pigs. | despite having only begun approximately 10,000 years ago, the process of domestication has resulted in a degree of phenotypic variation within individual species normally associated with much deeper evolutionary time scales. though many variable traits found in domestic animals are the result of relatively recent human-mediated selection, uncertainty remains as to whether the modern ubiquity of long-standing variable traits such as coat color results from selection or drift, and whether the unde ... | 2009 | 19148282 |
| the adult göttingen minipig as a model for chronic heart failure after myocardial infarction: focus on cardiovascular imaging and regenerative therapies. | porcine models have become increasingly popular in cardiovascular research. the standard farm pig rapidly increases in body weight and size, potentially confounding serial measurements of cardiac function and morphology. we developed an adult porcine model that does not show physiologic increases in heart mass during the study period and is suitable for long-term study. we compared adult minipigs with the commonly used adolescent yorkshire swine. myocardial infarction was induced in adult göttin ... | 2008 | 19149414 |
| bama miniature pigs (sus scrofa domestica) as a model for drug evaluation for humans: comparison of in vitro metabolism and in vivo pharmacokinetics of lovastatin. | the objective of this study was to demonstrate that bama miniature pigs are a suitable experimental animal model for the evaluation of drugs for man. to this end, in vitro lovastatin metabolism at the minipig liver microsomal level and in vivo pharmacokinetics were studied. results were compared with those obtained from humans. our data indicate that the main metabolites and enzyme kinetic parameters of lovastatin metabolism are similar in pigs and humans. triacetyloleandomycin, a specific inhib ... | 2008 | 19149415 |
| molecular magnetic resonance imaging of deep vein thrombosis using a fibrin-targeted contrast agent: a feasibility study. | to evaluate the value of a fibrin-specific mr contrast agent (ep-2104r; epix pharmaceuticals) for detection of deep vein thrombosis (dvt) and monitoring of percutaneous intervention for treatment. | 2009 | 19151606 |
| development of a recombinant antigen-based elisa for the sero-detection of porcine lymphotropic herpesviruses. | xenotransplantation using pigs as donor species carries a risk for the activation of latent porcine herpesviruses and potential transmission to the human recipient. the porcine lymphotropic herpesviruses (plhv-1, -2, -3) are widespread in domestic pigs and closely related to the human gammaherpesviruses, epstein-barr virus and kaposi sarcoma herpesvirus, causing lymphoproliferative disorders. plhv-1 has been associated with a porcine post-transplantation lymphoproliferative disorder (ptld), affe ... | 2008 | 19152663 |
| pretreatment with low-energy shock waves induces renal vasoconstriction during standard shock wave lithotripsy (swl): a treatment protocol known to reduce swl-induced renal injury. | to test the hypothesis that the pretreatment of the kidney with low-energy shock waves (sws) will induce renal vasoconstriction sooner than a standard clinical dose of high-energy sws, thus providing a potential mechanism by which the pretreatment sw lithotripsy (swl) protocol reduces tissue injury. | 2009 | 19154458 |
| measurements of subcutaneous tissue po2 reflect oxygen metabolism of the small intestinal mucosa during hemorrhage and resuscitation. an experimental study in pigs. | the first tissues to be deprived of perfusion and oxygenation in a hypovolemic situation and the last ones to be reperfused are the subcutaneous tissue and the gastrointestinal mucosa. we hypothesized that measurements of subcutaneous tissue gases and ph might reflect simultaneous changes in oxygenation of the intestinal mucosa. the aim of this study was to evaluate tissue gases and ph as measures of tissue oxygenation and tissue oxygen metabolism in subcutaneous and intestinal tissues simultane ... | 2009 | 19155629 |
| expanding the versatility of cardiac pet/ct: feasibility of delayed contrast enhancement ct for infarct detection in a porcine model. | it has recently been suggested that, similar to mri, ct can be used to detect infarcts at high resolution by delayed myocardial contrast enhancement. in cardiac pet/ct, this ability to detect infarcts may increase the versatility and integrative potential of pet and ct study components. we sought to determine the feasibility of delayed ct-enhancement in the pet/ct environment and compared it with pet-defined rest perfusion for the measurement of infarct size. | 2009 | 19164240 |
| a novel tgf-beta antagonist speeds reepithelialization and reduces scarring of partial thickness porcine burns. | scar formation after thermal injury is common and results in significant aesthetic and functional impairment. transforming growth factor beta (tgf-beta) plays a significant role in scar formation. we tested the hypothesis that a novel tgf-beta peptantagonist would reduce scar formation and wound contraction in partial thickness burns by using a randomized controlled experiment. the subjects include two domestic pigs (20-25 kg). forty burns were created on the animal's dorsum using an aluminum ba ... | 2009 | 19165091 |
| in vivo performance of selective electron beam-melted ti-6al-4v structures. | highly porous titanium structures are widely used for maxillofacial and orthopedic surgery because of their excellent mechanical properties similar to those of human bone and their facilitation of bone ingrowth. in contrast to common methods, the generation of porous titaniumproducts by selective electron beam melting (sebm), an additive manufacturing technology, overcomes difficulties concerning the extreme chemical affinity of liquid titanium to atmospheric gases which consequently leads to st ... | 2010 | 19165781 |
| salmonella, escherichia coli o157:h7 and e. coli biotype 1 in a pilot survey of imported and new zealand pig meats. | a pilot survey for the pathogens salmonella and escherichia coli o157:h7, and e. coli biotype 1 was conducted on 100 new zealand-produced (domestic) pig carcasses and 110 imported pig meat samples over an 8-month period to assess the likelihood of introduction of novel pathogen strains into new zealand (nz), and as a guide for development of a domestic pork national microbiological database programme. salmonella was not isolated from domestic pig carcasses or from pig meat imported from canada a ... | 2009 | 19171260 |
| time dependent vascular and myocardial responses of a second generation, small vessel, paclitaxel-eluting stent platform. | the purpose of this study was to evaluate the time-dependent vascular and myocardial responses to a second-generation, small vessel (< or =2.5 mm) paclitaxel-eluting stent (pes) platform. | 2009 | 19180652 |
| population dynamics of swine influenza virus in farrow-to-finish and specialised finishing herds in the netherlands. | influenza virus infections with subtypes h1n1, h3n2 and h1n2 are very common in domestic pigs in europe. data on possible differences of population dynamics in finishing pigs in farrow-to-finish herds and in specialised finishing herds are, however, scarce. the presence of sows and weaned piglets on the same premises may, however, affect the exposure of finishing pigs to influenza viruses. in a longitudinal study on 14 farrow-to-finish herds and 15 finishing herds, groups of pigs were followed b ... | 2009 | 19181461 |
| open versus laparoscopic retroperitoneal lymph node dissection: assessing adequacy of dissection in a porcine model. | laparoscopic retroperitoneal lymph node dissection (l-rplnd) is emerging as a viable alternative to traditional open retroperitoneal lymph node dissection (o-rplnd). despite numerous reports confirming clinical oncologic equivalency between the two approaches, however, concerns still remain over the adequacy of laparoscopic dissection. we therefore sought to compare the completeness of dissection between o-rplnd and l-rplnd in a porcine model. | 2009 | 19193133 |
| initial experimental evaluation of wireless capsule endoscopes in the bladder: implications for capsule cystoscopy. | cystoscopy remains one of the most important diagnostic procedures for the lower urinary tract. wireless capsule endoscopy was introduced in the 1990s but use to date is limited to gastroenterology. | 2009 | 19201077 |
| retrograde flush following warm ischemia in the non-heart-beating donor results in superior graft performance at reperfusion. | the use of non-heart-beating donors (nhbd) has been propagated as an alternative to overcome the scarcity of pulmonary grafts. the presence of postmortem thrombi, however, is a concern for the development of primary graft dysfunction. in this isolated lung reperfusion study, we looked at the need and the best route of preharvest pulmonary flush. | 2009 | 19201425 |
| expression of vascular endothelial growth factor receptors coincide with blood vessel in-growth and reactive bone remodelling in experimental intervertebral disc degeneration. | to analyze immunohistochemically the localization of the vegf receptors in experimental intervertebral disc degeneration tissues in a pig model. | 2008 | 19210865 |
| effects of stomach inflation on haemodynamic and pulmonary function during spontaneous circulation in pigs. | stomach inflation during mask ventilation is frequent, but the effects on haemodynamic and pulmonary function are unclear. we evaluated the effects of stomach inflation on haemodynamic and pulmonary function during spontaneous circulation in a porcine model. | 2009 | 19211181 |
| endoscopic closure of the natural orifice transluminal endoscopic surgery (notes) access site to the peritoneal cavity by means of transmural resorbable sutures: an animal survival study. | endoscopic closure of the transgastric access site is still a critical area of active research and development into natural orifice transluminal surgery (notes). to date, no endoscopic technique has utilized resorbable transmural sutures for closure of the notes gastrostomy. | 2009 | 19214896 |
| african swine fever virus. | african swine fever virus (asfv) is a large, intracytoplasmically-replicating dna arbovirus and the sole member of the family asfarviridae. it is the etiologic agent of a highly lethal hemorrhagic disease of domestic swine and therefore extensively studied to elucidate the structures, genes, and mechanisms affecting viral replication in the host, virus-host interactions, and viral virulence. increasingly apparent is the complexity with which asfv replicates and interacts with the host cell durin ... | 2009 | 19216435 |
| characterization and zoonotic potential of endemic hepatitis e virus (hev) strains in humans and animals in hungary. | hepatitis e virus (hev) is a common cause of acute, fecally transmitted hepatitis in developing countries. identification of hev in indigenous human infection and in domestic pig raising the possibility that hev infection is also a zoonosis. objectives/study design: molecular detection and epidemiology of hev in humans (south-east hungary) with acute hepatitis and in domestic (pig, cattle) and wild (boar and roe-deer) animals (countrywide) by elisa and rt-pcr. | 2009 | 19217346 |
| [molecular epidemiology of hepatitis e virus in hungary: endemic, food-borne zoonosis]. | hepatitis e virus (hev) is one of a common cause of acute, fecally transmitted hepatitis in developing countries. identification of hev in indigenous human infection and in domestic pig raises the possibility that hev infection is also a zoonosis. | 2009 | 19228570 |
| intraindividual comparison of image quality in mr urography at 1.5 and 3 tesla in an animal model. | experimental evaluation of image quality of the upper urinary tract in mr urography (mru) at 1.5 and 3 tesla in a porcine model. | 2008 | 19238642 |
| percutaneous left ventricular assist in ischemic cardiac arrest. | ischemic cardiac arrest represents a challenge for optimal emergency revascularization therapy. a percutaneous left ventricular assist device (lvad) may be beneficial. | 2009 | 19242324 |
| epinephrine reduces cerebral perfusion during cardiopulmonary resuscitation. | epinephrine has been the primary drug for cardiopulmonary resuscitation (cpr) for more than a century. the therapeutic rationale was to restore threshold levels of myocardial and cerebral blood flows by its alpha1 (alpha1) and alpha2 (alpha2)-adrenergic agonist vasopressor actions. on the basis of coincidental observations on changes in microvascular flow in the cerebral cortex, we hypothesized that epinephrine selectively decreases microvascular flow. | 2009 | 19242339 |
| phase-contrast mri-based elastography technique detects early hypertensive changes in ex vivo porcine aortic wall. | to measure the elastic properties of ex vivo porcine aortas in control and hypertensive groups using a phase contrast magnetic resonance imaging (mri)-based elastography technique. | 2009 | 19243040 |
| a stochastic model to quantify the risk of introduction of classical swine fever virus through import of domestic and wild boars. | classical swine fever (csf) is a disease of pigs that imposes major hardship on the industry of infected regions. the recent history of csf epidemics suggests that animal movements remain the main source of csf virus (csfv) infection for susceptible populations in europe. this study presents an assessment of the risk of introducing csfv into spain through the importation of live susceptible animals. results suggest that, if prevailing conditions persist, introduction of csfv into spain is likely ... | 2009 | 19243649 |
| isolate designation and characterization of toxoplasma gondii isolates from pigs in the united states. | pigs are considered to be the most important meat source of toxoplasma gondii for humans in the united states. in the present study, 168 t. gondii isolates (designated tgpgus15-182) from various sources were genotyped using 10 polymerase chain reaction-restriction fragment length polymorphism (pcr-rflp) markers (sag1, sag2, sag3, btub, gra6, c22-8, c29-2, l358, pk1, and apico). genotyping data from an additional 14 isolates collected from t. gondii-infected pigs in maryland were included for ana ... | 2009 | 19245283 |
| the effects of fasting and general anesthesia on serum chemistries in kcg miniature pigs. | investigators are obligated to optimize the perioperative care of experimental animals, but little is known about the effects of anesthesia and surgery on serum chemistries in kcg pigs. the objective of this study was to examine the influence of fasting and surgery under general anesthesia on 27 serum chemistries in kcg miniature pigs to improve management. crossbred kcg minipigs were used at a mean of 12.3 mo of age (range, 8.6 to 14.9) and 33.4 kg of body weight (range, 24.0 to 40.2). serum ch ... | 2009 | 19245748 |
| effects of streptozotocin-induced diabetes in domestic pigs with focus on the amino acid metabolism. | streptozotocin (stz) given intravenously destroys pancreatic beta cells and is widely used in animal models to mimic type 1 diabetes. the effects of stz on the clinical state of health and metabolism were studied in six high health certified domestic pigs weighing 19+/-1.3 kg at the start of the experiment. a single stz dose of 150 mg/kg of body weight successfully induced hyperglycaemia and alterations in amino acid metabolism. within 9 h after stz administration, the blood glucose values fell ... | 2009 | 19246503 |
| animal evolution during domestication: the domesticated fox as a model. | we review the evolution of domestic animals, emphasizing the effect of the earliest steps of domestication on its course. using the first domesticated species, the dog (canis familiaris), for illustration, we describe the evolutionary peculiarities during the historical domestication, such as the high level and wide range of diversity. we suggest that the process of earliest domestication via unconscious and later conscious selection of human-defined behavioral traits may accelerate phenotypic v ... | 2009 | 19260016 |
| cysticercosis of soft tissue. | cysticercosis is a systemic illness caused by dissemination of the larval form of the pork tapeworm, taenia solium. a high prevalence has been reported from the developing countries because of the co-existence of poor sanitary conditions and domestic pig raising. human cysticercosis occurs when eggs are ingested via faecal-oral transmission from a tapeworm host. the human then becomes an accidental intermediate host, with development of cysticerci within organs. cysticercosis is a preventable fa ... | 2009 | 19260577 |
| the association between central venous pressure, pneumoperitoneum, and venous carbon dioxide embolism in laparoscopic hepatectomy. | laparoscopic hepatectomy (lh) is increasingly used. however, the safety and outcomes of lh have yet to be elucidated. the risk of venous gas embolism is increased during liver parenchymal transection. this risk may be increased with positive pressure carbon dioxide (co(2)) pneumoperitoneum (pp). this may be exacerbated further when low central venous pressure (cvp) anesthesia is used to minimize hemorrhage during liver resection. | 2009 | 19266234 |
| giardia genotypes in pigs in western australia: prevalence and association with diarrhea. | little is known of the prevalence of giardia species and genotypes in pre- and post-weaned domestic pigs. in the present study, a total of 297 pig faecal samples were screened for the presence of giardia by pcr and genotyped. an overall prevalence of 31.1% (90/289) (25.8, 36.5 ci) was detected. giardia was detected in 17% (23/123) (11.8-25.6 ci) of pre-weaned piglet faecal samples and 41% (64/156) (33.3-48.7 ci) post-weaned faecal samples analysed. sequence analysis identified assemblage a and e ... | 2009 | 19271283 |
| comparison of two different paclitaxel-coated balloon catheters in the porcine coronary restenosis model. | drug-eluting balloon (deb) catheters coated with paclitaxel in a water-soluble matrix have shown beneficial effects in the treatment and prevention of restenosis in the porcine coronary overstretch model and in clinical trials. adherence of paclitaxel, same dose, on another recently introduced coated percutaneous coronary intervention (pci) catheter (dior) is mediated by a roughened balloon surface. only scarce experimental and clinical data has been published on the new coating method. the aim ... | 2009 | 19280084 |
| a family of splice variants of cstf-64 expressed in vertebrate nervous systems. | alternative splicing and polyadenylation are important mechanisms for creating the proteomic diversity necessary for the nervous system to fulfill its specialized functions. the contribution of alternative splicing to proteomic diversity in the nervous system has been well documented, whereas the role of alternative polyadenylation in this process is less well understood. since the cstf-64 polyadenylation protein is known to be an important regulator of tissue-specific polyadenylation, we examin ... | 2009 | 19284619 |
| wireless video capsule enteroscopy in preclinical studies: methodical design of its applicability in experimental pigs. | the aim of this project was to develop a methodology to introduce wireless video capsule endoscopy in preclinical research. five mature female pigs (sus scrofa domestica) were selected for the study. capsule endoscopes (the endocapsule system; olympus) were introduced into the duodenum endoscopically in each of the animals. the life span of batteries (i.e., total time of endoscopy recording) was 487-540 min (median 492 min). the capsule endoscope reached the cecum during enteroscopy once (after ... | 2010 | 19294508 |