| the effect of freezing and storage at -60 degrees c on the viability of mycobacterium leprae. | | 1971 | 4944742 |
| armadillo may aid leprosy research. | | 1971 | 4944922 |
| bacteriology and pathological study of leprous lesions in the footpads of mice. | | 1970 | 4944997 |
| acid-fast bacilli in the bone marrow in leprosy. | | 1971 | 4945324 |
| cultivation of the douglas strain of mycobacterium lepraemurium in continuous culture. | cultivation of mycobacterium lepraemurium in cell-free media has not yet been successful, perhaps because of deterioration of the nutritional quality of the medium with prolonged incubation at 37 degrees c. trials with a continuous culture technique, involving regular change of a simple liquid medium prepared from human placenta, demonstrated active fission of the myco. lepraemurium cells. abundant growth in the form by macroscopically visible colonies has not been achieved even after prolonged ... | 1971 | 4945632 |
| characterization of the cellular immune defect in lepromatous leprosy: a specific lack of circulating mycobacterium leprae-reactive lymphocytes. | | 1971 | 4945738 |
| [lysosomes in the pathology of leprosy]. | | 1971 | 4945785 |
| the multiplication of mycobacterium leprae in mouse foot-pads and the ambient temperatures. | | 1971 | 4946423 |
| bacterial counts of mycobacterium leprae on media enriched by substances of mycobacterial origin. | | 1971 | 4947057 |
| [objective validity of the culture method of m. leprae using cell-free, semi-liquid agar media]. | | 1971 | 4947894 |
| the impact of experimental human leprosy in the mouse on leprosy research. | | 1971 | 4948076 |
| the response of the patient with leprosy toward mycobacterium leprae injected with lepromin. a histopathologic study four hours after injection. | | 1971 | 4948077 |
| observations on in vitro survival of mycobacterium leprae. | | 1971 | 4948078 |
| the present state of growth of m. leprae under in vitro conditions. | | 1971 | 4948079 |
| histologic changes evoked in mice by freund's adjuvant, complete with m. leprae. | | 1971 | 4948082 |
| immunologic researches in leprosy. diagnostic applications. | | 1971 | 4948090 |
| antigenic properties of some mycobacterial strains isolated and cultivated from leprosy tissue. | | 1971 | 4948091 |
| leprosy--research at the forschungsinstitut borstel. | | 1971 | 4948101 |
| attempts to establish the armadillo (dasypus novemcinctus linn.) as a model for the study of leprosy. i. report of lepromatoid leprosy in an experimentally infected armadillo. | | 1971 | 4948218 |
| the treatment of leprosy with the sulfones. i. faget's original 22 patients. a thirty-year follow-up on sulfone therapy for leprosy. | | 1971 | 4948221 |
| activity against m. leprae of lincomycin and two derivatives, of amicetin, phosphonomycin and two derivatives of tetrahydronaphthylaminopropylpiperidine. | | 1971 | 4948222 |
| delayed lepromin reaction and bcg application in first grade school children in s. paulo, brazil. | | 1971 | 4948223 |
| m. leprae and its affinity for nerves. | | 1971 | 4948225 |
| studies on the determination of the minimal inhibitory concentration of 4,4'-diamino-diphenyl-sulphone (dapsone, dds) against mycobacterium leprae. | | 1971 | 4948480 |
| bacteriological effect of lamprene (clofazimine) in lepromatous leprosy (report of one year's treatment of 44 patients with 100 mg of lamprene daily). | | 1971 | 4948481 |
| the sfg (solid, fragmented, granular) index for bacterial morphology. | | 1971 | 4948482 |
| further electron-microscopic observations of mycobacterium lepraemurium. | | 1971 | 4948636 |
| transformation of leprous lymphocytes by leprolin, tuberculin and phytohemagglutinin. | | 1971 | 4949308 |
| effect of dapsone in eliminating m. leprae from the skin of lepromatous patients, a study of 609 cases. | | 1971 | 4949310 |
| statistical calculations of the confidence interval and significant difference ranges of the morphologic index. | | 1971 | 4949311 |
| fate of mycobacterium leprae in macrophages. | | 1971 | 4949314 |
| mycobacterium leprae in cultured mouse peritoneal macrophages: in vivo infection-in vitro cultivation. | | 1971 | 4949821 |
| the first decade in experimental leprosy. | considerable developments have occurred in the application of the method for growing mycobacterium leprae in the mouse foot-pad since it was first described about 10 years ago. the method has been used to study growth curves and histology in normal and in thymectomized irradiated mice, to identify supposed isolates of myco. leprae that have been made in tissue-culture or in non-living media, to evaluate tests of experimental vaccines, to investigate applications to clinical investigations (the l ... | 1971 | 4950564 |
| [hand muscle paralysis in leprosy and its surgical treatment]. | | 1971 | 4951024 |
| demonstration of mycobacterium leprae in tissue. demonstration by means of khanolkar's concentration test followed by fluorescent staining. | | 1966 | 4952823 |
| some immunologic aspects of leprosy. | | 1965 | 4954233 |
| antigenic structure of mycobacterium lepraemurium. i. presence of avian type alpha antigen in strain of m. lepraemurium. | | 1966 | 4958073 |
| leprosy. some analogies and contrasts with tuberculosis. | | 1967 | 4959682 |
| phenoloxidase of mycobacterium leprae. | | 1967 | 4964554 |
| inhibition of haemaggregation by lepromin and other mycobacterial substances. | | 1967 | 4965252 |
| cell walls from mycobacterium tuberculosis (bcg) as vaccine against mycobacterium leprae infections in mice. | | 1968 | 4967027 |
| effect of phytohemagglutinin and various mycobacterial antigens on lymphocyte cultures from leprosy patients. | | 1968 | 4967852 |
| antigen-antibody analyses in mycobacteria, in particular, mycobacteria of fish origin with special reference to mutual relationship among those and m. tuberculosis, m. leprae and m. leplaemurium. | | 1967 | 4968092 |
| oxidation of phenolic compounds by mycobacterium leprae and inhibition of phenolase by substrate analogues and copper chelators. | experiments were conducted on the substrate specificity of phenoloxidase in mycobacterium leprae, by using various phenolic compounds. comparative studies were carried out with the enzyme from mammalian and plant sources. the phenolase of m. leprae was found to be similar to the enzyme of plant origin in oxidizing a variety of substrates; it was different from the mammalian enzyme, which has a limited substrate specificity. the findings confirmed that phenoloxidase is a specific property of m. l ... | 1968 | 4970222 |
| leprosy in the toronto area. | | 1968 | 4970563 |
| properties of phenoloxidase in mycobacterium leprae. | | 1968 | 4971444 |
| [presence of an antigen in mycobacterium lepraemurium which is also common in mycobacterium leprae and nocardia brasilensis]. | | 1967 | 4971556 |
| pathogenic mycobacteria. | | 1965 | 4971875 |
| repository drugs. v. 4',4'''-[p-phenylenebis(methylidyneimino-p-phenylenesulfonyl)]bisacetanilide (psba) and related 4',4'''-[bis(imino-p-phenylenesulfonyl)]bisanilides, a novel class of long-acting antimalarial and antileprotic agents. | | 1969 | 4977944 |
| a study of antibody response in leprosy. | | 1969 | 4980113 |
| timely topics in microbiology: mycobacteria 1967-1968. | | 1969 | 4982014 |
| histological changes evoked in mice by freund's complete adjuvant. | | 1969 | 4982034 |
| effect of inhibitors on phenoloxidase of mycobacterium leprae. | previous results had shown that the human leprosy bacilli possess a phenoloxidase, which, when compared with the enzyme from mammalian and plant sources, seemed unique in the range of substrates utilized and in the nature of the products formed. the effect of several inhibitors on the enzyme in mycobacterium leprae was tested. compounds which bind copper were found to be more effective than substrate analogues. diethyldithiocarbamate penetrated the bacillus and completely suppressed its phenolas ... | 1969 | 4982199 |
| biology of the mycobacterioses. statement of questions. | | 1968 | 4985918 |
| biology of the mycobacterioses. metabolism of in vivo grown mycobacteria. | | 1968 | 4985920 |
| effect of immunosuppressive drugs on infection in mice by m. marinum (balnei), m. tuberculosis and m. leprae. | | 1967 | 4989504 |
| studies on the antigenic specificity of mycobacterium leprae. i. demonstration of soluble antigens in leprosy nodules by immunodiffusion. | | 1970 | 4990996 |
| the ecology of the atypicalmycobacteria. | | 1971 | 4991961 |
| [further studies on the serological diagnosis of leprosy. ii. effect of the rate of development and treatment on the result of complement fixation tests in comparison to bacilloscopy]. | | 1970 | 4992242 |
| bacterial negativity and reactivation (relapse) of lepromatous outpatients under sulfone treatment. | | 1970 | 4993550 |
| studies of immune mechanisms in leprosy. 3. the role of cellular and humoral factors in impairment of the in vitro immune response. | | 1971 | 4995005 |
| unusual effects of reducing agents on 0-diphenoloxidase of mycobacterium leprae. | reducing agents had no effect on the oxidation of 3,4-dihydroxyphenylalanine (dopa) to quinone by mycobacterium leprae; no quinone formation by o-diphenoloxidase of mammalian or plant origin was detected under similar experimental conditions. ascorbic acid and reduced glutathione prevented further oxidation and polymerization of the quinone to melanin by m. leprae; cysteine was less effective. in the presence of reducing agents, the quinone (indole-5,6-quinone) formed from dopa by m. leprae was ... | 1971 | 4999415 |
| immunologic analysis of mycobacterium leprae antigens by means of diffusion-in-gel methods. | | 1971 | 5003224 |
| neurofibromatosis and leprosy. | | 1971 | 5003511 |
| in vitro behavior of macrophages from healthy persons against m. leprae and other mycobacteria. | | 1971 | 5004598 |
| problems in the cultivation of mycobacterium leprae. related cultivation and biochemical studies with mycobacterium lepraemurium. | | 1971 | 5169802 |
| the activity of various antituberculous drugs in suppressing experimental mycobacterium leprae infection in mice. | | 1971 | 5169803 |
| leprosy and genetics. a review of past research with remarks concerning future investigations. | the few geneticists who are interested in leprosy have been working in this field only since 1962, and have made little progress in solving the problems presented by susceptibility to this disease.this paper reviews the research that has been conducted, with particular reference to the search for associations between leprosy and certain genetic markers. in each area, the advantages and limitations of different techniques are described, and attention is drawn to sources of bias that may invalidat ... | 1967 | 5301388 |
| immunological aspects of leprosy with special reference to autoimmune diseases. | leprosy, particularly lepromatous leprosy, is associated with a multitude of (auto) immune aberrations, and its clinical features also have much in common with the collagen diseases. immunopathological studies of the 2 groups of diseases may thus elucidate the basic mechanisms of both.the reported evidence for a genetically determined hyporeactivity of cell-mediated (cm) immunity in lepromatous subjects is reviewed; most, but not all, of the findings fit such a hypothesis well. the possibility r ... | 1969 | 5309531 |
| studies towards the standardization of lepromin. progress and prospects. | because of the wide range of concentrations of mycobacterium leprae in existing lepromins the authors studied methods of producing a standardizable lepromin containing 160 million bacilli/ml. the effects of using different dilutions of lepromin on the incidence of false-positive reactions were also studied.progress reported includes a convenient method for preparing large batches of non-sedimenting lepromin, which is directly suitable for microscopic counting of myco. leprae cells; and a validat ... | 1970 | 5311057 |
| some recent laboratory findings on mycobacterium leprae. implications for the therapy, epidemiology and control of leprosy. | from changes in the morphology and viability of mycobacterium leprae in infected mice, some authors have concluded that the majority of smear-positive human lepromatous patients become non-infectious within 3-4 months of the beginning of regular treatment with sulfones, even at dosages equivalent to only one-hundredth of the conventional daily dose-namely, 1 mg daily. these very low dosages have, however, not been advocated because of the risk that resistant strains of myco. leprae might develop ... | 1970 | 5313068 |
| immunological problems in leprosy research. 1. clinical and pathological spectrum of leprosy. | this paper discusses the evidence for and against the view that the spectrum of pathological changes in leprosy, extending from the lepromatous form to the tuberculoid form, may be caused by differences in the immune responses of patients. patients with the tuberculoid form of leprosy generally have well-developed specific cell-mediated immunity, but in a large proportion of patients with lepromatous leprosy the specific cell-mediated immunity to mycobacterium leprae and sometimes to other antig ... | 1970 | 5314019 |
| transmission of human leprosy to experimental animals: studies with "chatterjee" bacilli. | | 1965 | 5318610 |
| [cultivation of mycobacterium leprae murium and mycobacterium leprae by the tissue culture]. | | 1965 | 5319191 |
| [lepromatous leprosy induced by inoculation of m. leprae into the plantar pads of rats fed with pro-oxidant diets]. | | 1965 | 5319401 |
| [mycobacterium leprae]. | | 1965 | 5320484 |
| temperature optimum of mycobacterium leprae in mice. | shepard, charles c. (communicable disease center, atlanta, ga.). temperature optimum of mycobacterium leprae in mice. j. bacteriol. 90:1271-1275. 1965.-mycobacterium leprae multiplied most rapidly in foot pads of mice kept at an air temperature of 20 c. at air temperatures of 15 and 25 c, bacillary multiplication was slightly slower; at 10 and 30 c, distinctly slower; and at 4 and 35 c, no bacillary multiplication was detected. the temperature of the foot pad tissues of mice kept at an air tempe ... | 1965 | 5321481 |
| the need for bringing leprosy research into universities. | | 1965 | 5322697 |
| gerhard henrik armauer hansen. what did he see and when? | | 1965 | 5322698 |
| further analysis of the growth (elongation) phenomenon of mycobacterium lepraemurium in vitro, and relevant studies with mycobacterium leprae. | | 1965 | 5322700 |
| approaches to cultivation of m. leprae in a new laboratory. | | 1965 | 5322701 |
| stability of mycobacterium leprae and temperature optimum for growth. | | 1965 | 5322702 |
| growth habits of mycobacterium leprae. their implications. | | 1965 | 5322703 |
| the cultivation of mycobacterium leprae. search for a rational approach. | | 1965 | 5322704 |
| studies on m. lepraemurium and m. leprae in tissue culture. | | 1965 | 5322705 |
| mycobacterium lepraemurium and mycobacterium leprae in cultures of mouse peritoneal macrophages (preliminary results). | | 1965 | 5322706 |
| recent bacteriologic, immunologic and pathologic studies on experimental human leprosy in the mouse foot pad. | | 1965 | 5322707 |
| considerations of the application of the foot pad technic in leprosy research. | | 1965 | 5322708 |
| observations on the inoculation of m. leprae in the foot pad of the white rat. | | 1965 | 5322709 |
| electron microscopy. approach to leprosy research. | | 1965 | 5322710 |
| problems requiring solution through field studies. | | 1965 | 5322712 |
| experimental infection of the golden hamster with mycobacterium leprae. | | 1965 | 5322768 |
| mycobacterium leprae: viability at 0 degrees c, 31 degrees c, and during freezing. | | 1965 | 5322769 |
| [a contribution on leprosy in our latitude]. | | 1965 | 5323181 |
| use of the mouse foot pad in studying thermoresistance of mycobacterium leprae. | | 1965 | 5323545 |
| comparative behaviour of a strain of m. leprae in 5 different mouse strains and in thymectomized mice. | | 1965 | 5323831 |
| contribution to the study of borderline and indeterminate leprosy. | | 1965 | 5324502 |
| some interesting observations on the cultivation mycobacteria leprae. | | 1966 | 5324886 |
| progress in leprosy research. | | 1966 | 5325357 |
| some observations on the morphological index in lepromatous leprosy. | | 1966 | 5325397 |