| thyroid function tests in preterm infants born to preeclamptic mothers with placental insufficiency. | since preeclampsia causes placental insufficiency, it can be hypothesized that it decreases placental passage of thyroxine (t4) from mother to infant and thus may deepen the transient hypothyroxinemia seen in preterm infants after birth. the aim of this study was to compare thyroid function tests of preterm infants born to preeclamptic mothers with placental insufficiency with preterm infants born to mothers without placental insufficiency. | 2003 | 14594173 |
| diagnostic delay and prognosis in invasive bladder cancer. | to study diagnostic delay in invasive bladder cancer in a population-based material with long-term follow-up, and to evaluate whether delay in diagnosis affects the risk of bladder cancer death. | 2003 | 14594688 |
| [toxic multinodular goiter]. | we report a series of 70 patients with toxic multinodular goiter (tmng) and analyze results after surgical removal. | 2003 | 14595241 |
| hoffman's syndrome: pseudohypertrophic myopathy as initial manifestation of hypothyroidism. case report. | the frequency of myopathy in hypothyroidism ranges from 30 to 80%. the major symptoms related are weakness, muscular cramps and myalgia. the pseudohyperthrophic form is called hoffman's syndrome. the electrophysiological study reveals myopathy, neuropathy or mixed pattern. laboratorial investigation generally shows increased levels of muscle enzymes and low serum thyroid hormones, with thyrotrophic-stimulating hormone (tsh) elevated. the treatment consists in hormone replacement and the prognosi ... | 2003 | 14595495 |
| prevalence of thyroid dysfunction in patients with acute atrial fibrillation attended at a cardiology emergency room. | atrial fibrillation occurs frequently in patients with thyrotoxicosis, while it has low prevalence in adults of the general population. the prevalence of thyroid dysfunction in subjects with atrial fibrillation is 0 to 24%, a wide variation that is attributed to the different methodologies applied. however, continuous use of amiodarone in patients with previous atrial fibrillation may interfere with these prevalence rates. | 2003 | 14595508 |
| nmr structure and dynamics of the second transmembrane domain of the neuronal acetylcholine receptor beta 2 subunit. | structure and backbone dynamics of a selectively [(15)n]leu-labeled 28-residue segment of the extended second transmembrane domain (tm2e) of the human neuronal nicotinic acetylcholine receptor (nachr) beta(2) subunit were studied by (1)h and (15)n solution-state nmr in dodecylphosphocholine micelles. the tm2e structure was determined on the basis of the nuclear overhauser effects (noes) and the hydrogen bond restraints, which were inferred from the presence of h(alpha)(i)-h(n)(i+3), h(alpha)(i)- ... | 2003 | 14596621 |
| segg endonuclease promotes marker exclusion and mediates co-conversion from a distant cleavage site. | bacteriophages t2 and t4 are closely related t-even phages. however, t4 genetic markers predominate in the progeny of mixed infections, a phenomenon termed marker exclusion. one region previously mapped where the frequency of t2 markers in the progeny is extremely low is located around gene 32. here, we describe segg, a giy-yig family endonuclease adjacent to gene 32 of phage t4 that is absent from phage t2. in co-infections with t2 and t4, cleavage in t2 gene 32 by t4-encoded segg initiates a g ... | 2003 | 14596796 |
| defining the bacteriophage t4 dna packaging machine: evidence for a c-terminal dna cleavage domain in the large terminase/packaging protein gp17. | double-stranded dna packaging in bacteriophage t4 and other viruses occurs by translocation of dna into an empty prohead by a packaging machine assembled at the portal vertex. coordinated with this complex process is the cutting of concatemeric dna to initiate and terminate dna packaging and encapsidate one genome-length viral dna. the catalytic site responsible for cutting, and the mechanisms by which cutting is precisely coordinated with dna translocation remained as interesting open questions ... | 2003 | 14596798 |
| lip cancer treatment with high dose rate brachytherapy. | we present 39 patients with lip carcinoma treated with hdr, (needles) with 5-5.5 gy per 8-10 fractions b.i.d. (total dose 40.5-45 gy). three-year cause-specific survival and local control are 91 and 88% (95% t1-2, 74% t4, p<0.05). acute and chronic reactions are like ldr cases. we think that hdr results are equivalent to ldr. | 2003 | 14597364 |
| intrahepatic cholangiocarcinoma: macroscopic type and stage classification. | the liver cancer study group of japan established a classification of macroscopic type and the tnm staging of intrahepatic cholangiocarcinoma (icc). with the observation of more than 240 resected cases of icc, three fundamental types were established. they were: (1) mass-forming (mf) type, (2) periductal-infiltrating (pi) type, and (3) intraductal growth (ig) type. the mf type forms a definite mass, located in the liver parenchyma. the pi type is defined as icc which extends mainly longitudinall ... | 2003 | 14598147 |
| persistence of mild hyperthyrotropinemia after discontinuation of three-year course of low-dose l-thyroxine therapy in infants with borderline hypothyroidism. | treatment plan for neonates with borderline hypothyroidism (persistent hyperthyrotropinemia with normothyroxinemia) has not been established. in this study, changes in thyroid function after discontinuation of low-dose l-thyroxine (l-t4) supplement in infants with the condition were evaluated. fourteen infants with hyperthyrotropinemia at neonatal screening had repeated hyperthyrotropinemia (> 8 mu/l) with normothyroxinemia. tsh response was exaggerated at trh testing. the subjects were treated ... | 2003 | 14599110 |
| in vitro studies on dna-photosensitization by different drug stereoisomers. | the possible stereoselectivity in dna-photosensitization by carprofen (a nsaid drug) and ofloxacin (a fluoroquinolone agent) was investigated. the different drug stereoisomers or racemic mixtures were uva-irradiated and the relaxation of the supercoiled circular pbr322 quantified by electrophoresis. formation of single strand breaks was compared for each group of compounds. moreover a mechanistic study by means of repair enzymes: t4 endonuclease v (specific of cyclobutane pyrimidine dimers), e. ... | 2003 | 14599458 |
| hyperthyroidism modifies ecto-nucleotidase activities in synaptosomes from hippocampus and cerebral cortex of rats in different phases of development. | here we investigate the possible effects of the hyperthyroidism on the hydrolysis of the atp to adenosine in the synaptosomes of hippocampus, cerebral cortex and blood serum of rats in different developmental phases. manifestations of hyperthyroidism include anxiety, nervousness, tachycardia, physical hyperactivity and weight loss amongst others. the thyroid hormones modulate a number of physiological functions in central nervous system, including development, function, expression of adenosine a ... | 2003 | 14599486 |
| clinical, biochemical and therapeutical aspects of amiodarone-induced hypothyroidism (aih) in geriatric patients with cardiac arrhythmias. | the clinical features and the laboratory aspects of the amiodarone-induced hypothyroidism (aih) in the elderly as well as the effects of amiodarone treatment in aged aih people have not yet been well clarified. in the present paper, we evaluated 18 subjects of both sexes (7 females, 11 males), aged 65-83 years, affected by aih, recruited in central tuscany, italy. the patients were divided in two subsets on the basis of thyroid stimulating hormone (tsh) values: mild (tsh < 20 mu/l; group a, n=11 ... | 2004 | 14599701 |
| e-selectin, l-selectin, icam-1 and il-6 concentrations changes in the serum of patients with hyperthyroidism in the early period of radioiodine i-131 therapy. | among cytokines- interleukins: -6 and -8 (il-6, il-8) and e-selectin (e-sel.), l-selectin (l-sel.) and intercellular cell adhesion molecule-1 (icam-1) are the most important links in the initiation of the inflammatory process. taking into account that the inflammatory process is the basic stage of effective radioiodine therapy, we tried to compare the behaviour of the initial inflammatory factors in the early period of i-131 therapy (rai) of hyperthyroidism. the aim of the study was to estimate ... | 2002 | 14600946 |
| quantification of breast cancer blood flow in absolute units using gjedde-rutland-patlak analysis of 99mtc-mibi uptake. | scintimammography with 99mtc-mibi has been proven as efficient technique of diagnosis of breast cancer. nevertheless, quantification of breast carcinoma blood flow (bcbf) in absolute units is not yet developed. to compensate this, we analysed kinetics of 99mtc-mibi uptake in breast cancer using gjedde-rutland-patlak (grp) approach. | 1999 | 14600993 |
| definitive radiotherapy alone or combined with a planned neck dissection for squamous cell carcinoma of the pharyngeal wall. | in the current study,the authors analyzed the results of definitive radiotherapy for squamous cell carcinoma of the pharyngeal wall. | 2003 | 14601093 |
| temporal and topographic ultrastructural alterations of rat heart myofibrils caused by thyroid hormone. | in order to further our understanding regarding the temporal and topographic ultrastructural aspects of the myocardium under thyrotoxicosis, thyroxine (t4; 25 and 100 microg/100 g bw) was administered to young rats 24 hours after birth until 15 days. the animals were then sacrificed, the hearts excised and weighed, and the ventricle tissue samples were then processed for confocal and transmission electron microscopy. at 48/72 hours and 1 week after initiation of t4 treatment with 100 microg/100 ... | 2003 | 14601151 |
| [influence of inhaled nitric oxide on surfactant in the total cardiopulmonary bypass pig model]. | to study whether or not inhaled nitric oxide (ino) can improve surfactant production and pulmonary mechanics after cpb in pigs, and to seek the mechanism of lung injury during mechanical ventilation. | 2003 | 14601318 |
| soluble hla-g molecules are increased in lymphoproliferative disorders. | the immunomodulatory properties of soluble human leukocyte antigen g (shla-g) explain its potential interest in malignancies. hla-g frequently transcribed in lymphoproliferative disorders is rarely expressed at cell surface. in this article, we will demonstrate that the plasmatic level of soluble hla-g was significantly increased in 70% of b chronic lymphocytic leukemia, 53% of non-hodgkin b lymphoma (b-nhl), and 45% of t-nhl. to explain this variable secretion, the hla-g secreting cell was sear ... | 2003 | 14602240 |
| radical radiation vs surgery plus post-operative radiation in advanced (resectable) supraglottic larynx and pyriform sinus cancers: a prospective randomized study. | survival in head and neck cancers reflect loco-regional control. with an aim of organ and function preservation the present study was undertaken to compare local failure and survivals. | 2003 | 14602495 |
| comparative efficacy and side effects of the treatment of euthyroid goiter with levo-thyroxine or triiodothyroacetic acid. | euthyroid goiter is usually treated with tsh-inhibitory doses of levo-t(4) (l-t(4)). because triiodothyroacetic acid (triac) decreases tsh levels, the following study was perfomed: 36 euthyroid goitrous female patients (no cancer or chronic thyroiditis) were randomized to triac (19.6 micro g/kg) (n = 19) or l-t4 (1.7 microg/kg) (n = 17) treatment during 11 months. goiter volume; lumbar and femoral bone mineral density; serum osteocalcin; deoxypyridinoline; tsh; free t(4); total, high-density lip ... | 2003 | 14602763 |
| the syndrome of resistance to thyroid stimulating hormone. | resistance to thyroid stimulating hormone (tsh) is a syndrome of reduced sensitivity to a biologically active tsh molecule. subjects have elevated tsh levels but no goiter. however, thyroid hormone concentration may vary from normal to very high, depending on the severity of the resistance. individuals with very high tsh, low thyroxine (t4) and hypoplastic thyroid glands can be mistakenly diagnosed as having primary hypothyroidism due a defective development of the thyroid gland. those with norm ... | 2003 | 14604307 |
| perioperative chemotherapy in advanced bladder cancer - part ii: adjuvant treatment. | despite radical cystectomy, 40% of the patients with locally advanced disease and more than 80% of the patients with lymphatic metastases die tumor related. this provides the rationale for additional effective systemic therapy following surgery. in addition, previous surgery and consecutive histopathological or cell-based evaluation offers the advantage to expose only those patients to adjuvant systemic chemotherapy, who belong to a defined high-risk group. regional lymph node metastases range f ... | 2003 | 14605467 |
| recombinant human tsh changes the multidisciplinary approach to patients with differentiated thyroid carcinoma. two-year experience. | recombinant human tsh (rhtsh) is available for monitoring differentiated thyroid carcinoma. rhtsh testing modifies the guidelines for this disease. | 2003 | 14605601 |
| the thyroid during pregnancy: a physiological and pathological stress test. | pregnancy and the postpartum are times of marked and rapid change in the thyroid gland. normal physiological changes include enhanced thyroid hormone production, modulation of thyroid hormone metabolism by placental deiodinases, and decreasing titers of thyroid antibodies in thyroid antibody positive women. hyperemesis gravidarum is associated with suppressed thyroid stimulating hormone levels and free t4 elevations. graves' disease typically becomes quiescent during pregnancy, followed by a pos ... | 2003 | 14605605 |
| [indications for neoadjuvant therapy in rectal carcinoma]. | pre- and postoperative adjuvant treatments for locally advanced, operable (r0 resection) rectum carcinoma have led to improved results. in principle, according to the interdisciplinary consensus of the german cancer society, the recommended treatment for rectum carcinoma (t3/4; n0; m0; any t stage; n+; m0) is still postoperative adjuvant radiochemotherapy. in the meantime, however, based on the good results obtained from various clinical trials preoperative adjuvant treatment is favored internat ... | 2003 | 14605730 |
| evening and morning eeg differences between young men and women adults. | evening and morning waking eeg (eyes closed) was recorded in 16 women and 13 men aged 18-26 years old. participants were fitted with a 13-electrode montage (fp1, fp2, fz, f7, f8, c3, c4, t3, t4, p3, p4, o1, and o2) referred to linked ears. for each recording electrode, eeg total spectral amplitude power (microv/hz, 0.75-19.75 hz) was compared using 2 (gender) x 2 (moments) analyses of variance for repeated measures and lsd post-hoc tests. we found significant simple gender effects, with women di ... | 2003 | 14607135 |
| the role of dna recombination in herpes simplex virus dna replication. | in many organisms the processes of dna replication and recombination are closely linked. for instance, in bacterial and eukaryotic systems, replication forks can become stalled or damaged, in many cases leading to the formation of double stranded breaks. replication restart is an essential mechanism in which the recombination and repair machinery can be used to continue replication after such a catastrophic event. dna viruses of bacteria such as lambda and t4 also rely heavily on dna recombinati ... | 2003 | 14609200 |
| fruit extract of emblica officinalis ameliorates hyperthyroidism and hepatic lipid peroxidation in mice. | the ethanolic extract from the fruits of emblica officinalis gaertn (euphorbiaceae) was investigated to evaluate its possible ameliorating effects, on the l-thyroxine (l-t4) induced hyperthyroidism and on hepatic lipid peroxidation in mice. while an increase in serum t3 (triiodothyronine) and t4 (thyroxine) concentrations, and in a thyroid dependent parameter, hepatic glucose 6-phospatase (glu-6-pase) activity was observed in l-t4 (0.5 mg/kg/d) treated animals, simultaneous oral administration o ... | 2003 | 14609291 |
| brown-sèquard syndrome produced by cervical disc herniation: report of two cases and review of the literature. | brown-sèquard syndrome is most commonly seen with spinal trauma and extramedullary spinal neoplasm. a herniated cervical disc has rarely been considered to be a cause of brown-sèquard syndrome. | 2003 | 14609700 |
| role of his-16 in turnover of t4 pyrimidine dimer glycosylase. | previously, the histidine residue at position 16 in the mature t4 pyrimidine dimer glycosylase (t4-pdg) protein has been suggested to be involved in general (non-target) dna binding. this interpretation is likely correct, but, in and of itself, cannot account for the most dramatic phenotype of mutants at this position: their inability to restore ultraviolet light resistance to a dna repair-deficient escherichia coli strain. accordingly, this residue has been mutated to serine, glutamic, aspartic ... | 2004 | 14610082 |
| [the influence of surgical intervention on the functional status of hypophyseal-thyroid system in patients with acute destructive appendicitis]. | the changes of thyrotropin (tsg), thyroxin (t4) and triiodothyronine (t3) blood levels in patients with acute destructive appendicitis and initial decrease of t3, as well as its absorption of t4 by lymphocytes after operation were studied. it is established that "low t3 level syndrome" in surgical patients exceeds the limit of quantitative assessment of the level of thyroid hormones' concentration in peripheral blood. it includes also damage of functional intersystem (endocrine-immune) links. ho ... | 2003 | 14610789 |
| light-induced hormone conversion of t4 to t3 regulates photoperiodic response of gonads in birds. | reproduction of many temperate zone birds is under photoperiodic control. the japanese quail is an excellent model for studying the mechanism of photoperiodic time measurement because of its distinct and marked response to changing photoperiods. studies on this animal have suggested that the mediobasal hypothalamus (mbh) is an important centre controlling photoperiodic time measurement. here we report that expression in the mbh of the gene encoding type 2 iodothyronine deiodinase (dio2), which c ... | 2003 | 14614506 |
| structure of dna hexamer sequence d-cgatcg by two-dimensional nuclear magnetic resonance spectroscopy and restrained molecular dynamics. | solution conformation of self-complementary dna duplex d-cgatcg, containing 5' d-cpg 3' site for intercalation of anticancer drug, daunomycin and adriamycin, has been investigated by nuclear magnetic resonance (nmr) spectroscopy. complete resonance assignments of all the protons (except some h5'/h5" protons) have been obtained following standard procedures based on double quantum filtered correlation spectroscopy (dqf cosy) and two-dimensional nuclear overhauser effect (noe) spectra. analysis of ... | 2003 | 14616036 |
| broadening the criteria for avoiding staging bone scans in prostate cancer: a retrospective study of patients at the royal marsden hospital. | to determine if it is possible to exclude staging bone scans in a greater proportion of patients if more consideration is given to t stage and gleason score, as recent guidelines from the national institute of clinical excellence state that routine staging bone scans for prostate cancer are unnecessary in patients with a prostate specific antigen level (psa) of < 10 ng/ml and gleason scores of < 8. | 2003 | 14616446 |
| decrease in carotid intima-media thickness in hypothyroid patients after normalization of thyroid function. | this case-control study was carried out to assess whether levothyroxine (l-t4) replacement might cause regression of the enhanced atherosclerosis seen in hypothyroid patients. | 2003 | 14616885 |
| serum concentrations of adipocytokines in patients with hyperthyroidism and hypothyroidism before and after control of thyroid function. | adipose tissue is a hormonally active system that produces and releases different bioactive substances. leptin, adiponectin and resistin are some of the recently discovered adipocytokines that participate in the regulation of intermediate metabolism. the aim of this study was to evaluate the circulating levels of leptin, adiponectin and resistin in patients with thyroid dysfunction before and after normalization of thyroid function with appropriate therapy. | 2003 | 14616887 |
| [an applied anatomy study on bronchial artery and posterior intercostal artery]. | to provide anatomic data for clinical treatment of the right lung cancers at advanced or intermediate advanced stage. | 2003 | 14619589 |
| life-threatening hyponatremia due to cessation of l-thyroxine. | electrolyte disorders in hypothyroidism are frequently subtle and rarely observed in clinical practice. a 50-year-old woman was admitted to the emergency room with complaints of nausea, weakness, and lethargy. her medical history revealed total thyroidectomy two years earlier. she was commenced on l-thyroxine after the surgery. however, the patient stopped the treatment for three months. thyroid function tests showed free t3 0.80 pg/ml (n: 1.8-4.2), free t4 <0.20 ng/dl (n: 0.8-1.9), tsh 56.84 mi ... | 2003 | 14620714 |
| sustained hypomyelination and high serum thyroid hormone in aged black tremor hamster. | oligodendrocytes and myelin in the corpus callosum of black tremor and normal hamsters aged over 1.5 years were ultrastructurally examined to determine the myelination index (ratio of myelin thickness/diameter of axon), percentage of naked axons, and proportions of oligodendroglial subtypes (light, medium and dark). the mutant hamsters were remarkably hypomyelinated, with a low myelination index and a high proportion of naked axons, and high proportions of the dark subtypes. serum concentrations ... | 2003 | 14621228 |
| interaction of the c1 complex of complement with sulfated polysaccharide and dna probed by single molecule fluorescence microscopy. | the complex c1 triggers the activation of the complement classical pathway through the recognition and binding of antigen-antibody complex by its subunit c1q. the globular region of c1q is responsible for c1 binding to the immune complex. c1q can also bind nonimmune molecules such as dna and sulfated polysaccharides, leading either to the activation or inhibition of complement. the binding site of these nonimmune ligands is debated in the literature, and it has been proposed to be located either ... | 2003 | 14622259 |
| kinetics and thermodynamics of nick sealing by t4 dna ligase. | t4 dna ligase is an mg2+-dependent and atp-dependent enzyme that seals dna nicks in three steps: it covalently binds amp, transadenylates the nick phosphate, and catalyses formation of the phosphodiester bond releasing amp. in this kinetic study, we further detail the reaction mechanism, showing that the overall ligation reaction is a superimposition of two parallel processes: a 'processive' ligation, in which the enzyme transadenylates and seals the nick without dissociating from dsdna, and a ' ... | 2003 | 14622296 |
| regulation of translation of the head protein of t4 bacteriophage by specific binding of ef-tu to a leader sequence. | recent evidence indicates that translation elongation factor tu (ef-tu) has a role in the cell in addition to its well established role in translation. the translation factor binds to a specific region called the gol region close to the n terminus of the t4 bacteriophage major head protein as the head protein emerges from the ribosome. this binding was discovered because ef-tu bound to gol peptide is the specific substrate of the lit protease that cleaves the ef-tu between amino acid residues gl ... | 2003 | 14623179 |
| detection of endocrine-modulating effects of the antithyroid acting drug 6-propyl-2-thiouracil in rats, based on the "enhanced oecd test guideline 407". | the antithyroid acting drug propylthiouracil (ptu) was administered to male and female wistar rats at 0, 0.1, 1, or 10mg/kg body weight for 4 weeks according to the draft protocol of the "enhanced oecd test guideline 407" (enhanced tg 407) in order to investigate its suitability to detect endocrine-mediated effects. the study was conducted with two identical subsets of five animals per sex and dose each to provide data on sensitivity. the modified protocol includes the investigation of additiona ... | 2003 | 14623486 |
| letrozole versus tamoxifen in the treatment of advanced breast cancer and as neoadjuvant therapy. | letrozole, a third generation aromatase inhibitor, has been compared with tamoxifen in the treatment of advanced breast cancer and as neoadjuvant therapy. in a first-line trial in advanced disease, 939 post menopausal women were randomised double blind to receive treatment with letrozole 2.5 mg daily or tamoxifen 20 mg daily. letrozole was significantly superior in terms of median time to progression (9.4 months versus 6.1 months, p=0.0001), objective response (30% versus 20%, p=0.0006), and cli ... | 2003 | 14623523 |
| prognostic factors affecting the outcome of nasopharyngeal carcinoma. | the aim of the study is to evaluate patients with nasopharyngeal carcinoma treated with multisegmental intensity-modulated radiotherapy with or without chemotherapy and analyze patient, tumor and treatment characteristics, determining outcome. | 2003 | 14623917 |
| neo adjuvant tamoxifen in post menopausal patients with operable breast cancer. | tamoxifen is widely used as adjuvant therapy in receptor positive post menopausal breast cancer. little is known about its efficacy as neo adjuvant therapy in terms of breast conservation and improved survival. | 2003 | 14624772 |
| sage mrna expression in advanced-stage lung cancers. | sage and hage are recently isolated genes, which were thought to be expressed tumour-specifically, and are potentially coding for tumour-specific antigens recognized by t lymphocytes. the expression of these genes may serve as a useful diagnostic marker in detecting malignant disease. we report the correlation of sage and hage expression with clinicopathological features in patients with lung cancer who had undergone surgery. | 2003 | 14624785 |
| establishment of an hiv cell-cell fusion assay by using two genetically modified hela cell lines and reporter gene. | infection of human cells with the human immunodeficiency virus type i (hiv-1) can be mimicked by a fusion process between cells expressing the hiv envelope protein (env) and cells expressing both human cd4 together with the appropriate human chemokine receptors. in this study, a t-tropic hiv cell-cell fusion assay was established that utilized cd4, human cxcr4 and hiv nl4-3 gp160 as fusion components and a t7 polymerase-activated luciferase as a reporter system. the hela t4 cells used, expressed ... | 2003 | 14625051 |
| structure and morphogenesis of bacteriophage t4. | bacteriophage t4 is one of the most complex viruses. more than 40 different proteins form the mature virion, which consists of a protein shell encapsidating a 172-kbp double-stranded genomic dna, a 'tail,' and fibers, attached to the distal end of the tail. the fibers and the tail carry the host cell recognition sensors and are required for attachment of the phage to the cell surface. the tail also serves as a channel for delivery of the phage dna from the head into the host cell cytoplasm. the ... | 2003 | 14625682 |
| limited endoscopic thoracic sympathetic block for hyperhidrosis of the upper limb: reduction of compensatory sweating by clipping t4. | endoscopic thoracic sympathicotomy of t2 to t4 (ets 2-4) has evolved into an effective treatment for severe hyperhidrosis of the upper limb. complications such as bleeding or horner's syndrome are rare, but side effects such as compensatory and gustatory sweating occur in 30-50% of patients. following the lin-telaranta classification, we aimed to reduce these side-effects by clipping t4 solely [endoscopic thoracic sympathetic block (esb 4)]. we present our experience and clinical results using t ... | 2004 | 14625754 |
| effects of osteoporotic cytokines in ovary-intact and ovariectomised rats with induced hyperthyroidism; is skeletal responsiveness to thyroid hormone altered in estrogen deficiency? | this experimental study was designed to examine the effects of hyperthyroidism on osteoporotic cytokines such as interleukin (il)-1beta, il-6 and tumor necrosis factor (tnf)-alpha in the physiological concentrations and in the deficiency of estrogen. we investigated the effects of thyroid hormones on cytokines and bone metabolism in l-thyroxine induced ovary-intact and ovariectomised rats, as levels of cytokines were increased in hyperthyroidism. the rats were divided into three groups. in the f ... | 2003 | 14626509 |
| effect of donepezil on eeg spectral analysis in alzheimer's disease. | eeg spectral analysis allows a quantitative analysis of changes in the frequency bands during disease progression in alzheimer's disease (ad) and could be used to monitor treatment and disease progression. eighteen patients with probable ad were evaluated by folstein mini mental state examination (mmse) and eeg spectral analysis before donepezil treatment, 2 months after 5 mg/day and 4 months after the dose was raised to 10 mg/day. eeg evaluations were done in 4 derivations (t3-t5, t4-t6, c3-p3, ... | 2003 | 14626697 |
| thick melanoma in the elderly. | the objective of this analysis is to ascertain the natural history of elderly patients greater than 65 years of age with thick melanoma (t4) who were treated with surgery only. although there are multiple data on elderly patients, there is not a systematic review of survival in elderly patients over 65 years, and with our analysis we tried to enlighten this field in view especially of the growing population of the elderly in the united states. we retrospectively evaluated 112 patients with thick ... | 2003 | 14627262 |
| a novel approach to describe a u1 snrna binding site. | rna duplex formation between u1 snrna and a splice donor (sd) site can protect pre-mrna from degradation prior to splicing and initiates formation of the spliceosome. this process was monitored, using sub-genomic hiv-1 expression vectors, by expression analysis of the glycoprotein env, whose formation critically depends on functional sd4. we systematically derived a hydrogen bond model for the complementarity between the free 5' end of u1 snrna and 5' splice sites and numerous mutations followin ... | 2003 | 14627829 |
| real-time monitoring of nucleic acid ligation in homogenous solutions using molecular beacons. | nucleic acids ligation is a vital process in the repair, replication and recombination of nucleic acids. traditionally, it is assayed by denatured gel electrophoresis and autoradiography, which are not sensitive, and are complex and discontinuous. here we report a new approach for ligation monitoring using molecular beacon dna probes. the molecular beacon, designed in such a way that its sequence is complementary with the product of the ligation process, is used to monitor the nucleic acid ligat ... | 2003 | 14627838 |
| hypofractionated conformal radiotherapy in carcinoma of the prostate: five-year outcome analysis. | recent publications have indicated that the alpha/beta ratios for carcinoma of the prostate are much lower than had originally been thought, suggesting that prostate cancer may be highly sensitive to fraction size. we have reviewed our unique experience of the use of 3.13 gy fractions in a large cohort of men treated homogeneously in a single institute. | 2003 | 14630259 |
| acanthamoeba keratitis update-incidence, molecular epidemiology and new drugs for treatment. | a reliable figure for the expected incidence of acanthamoeba keratitis of one per 30000 contact lens wearers per year has now been obtained from a combination of three cohort and three questionnaire reporting surveys; 88% of cases wore hydrogel lenses and 12% wore rigid lenses. this figure now provides a basis for the expected number of cases against which to judge either epidemic outbreaks or effects of prevention with disinfecting solutions, better hygiene, or the use of disposable lenses. mol ... | 2003 | 14631394 |
| health-related quality of life after radical prostatectomy in japanese men with localized prostate cancer. | we evaluated retrospectively health-related quality of life (hrqol) after radical prostatectomy (rp) in japanese men with localized prostate cancer. | 2003 | 14633067 |
| effect of non-steroidal aromatase inhibitor on blood plasma ovarian steroid and thyroid hormones in laying hen (gallus domesticus). | hyline brown laying hens at 30 weeks of age were treated twice daily with fadrozole, a non-steroidal aromatase inhibitor (ai; 1 mg/kg body weight; i.m.) for six consecutive days; control hens received saline. blood was collected every day 0.5 h after oviposition, i.e. just before ai treatment. ovarian steroids: progesterone (p4), testosterone (t) and estradiol (e2), and iodothyronines: thyroxine (t4), triiodothyronine (t3) and reverse-triiodothyronine (rt3) were measured in blood plasma by radio ... | 2003 | 14633224 |
| the effect of right versus left lateral decubitus positions on induction of spinal anesthesia for cesarean delivery. | induction of spinal anesthesia for cesarean delivery in the left lateral (ll) decubitus position combined with intraoperative left uterine displacement may result in pooling of local anesthetic onto one side of the body. we studied the effect of the right lateral (rl) and ll decubitus positions during placement of spinal anesthesia on the intrathecal spread of 0.5% hyperbaric bupivacaine plus fentanyl in 60 term parturients. though all parturients acquired a loss of cold sensation at t4 15 min a ... | 2003 | 14633562 |
| mutations in a conserved motif inhibit single-stranded dna binding and recombination mediator activities of bacteriophage t4 uvsy protein. | the uvsy recombination mediator protein is critical for homologous recombination in bacteriophage t4. uvsy uses both protein-protein and protein-dna interactions to mediate the assembly of the t4 uvsx recombinase onto single-stranded (ss) dna, forming presynaptic filaments that initiate dna strand exchange. uvsy helps uvsx compete with gp32, the t4 ssdna-binding protein, for binding sites on ssdna, in part by destabilizing gp32-ssdna interactions, and in part by stabilizing uvsx-ssdna interactio ... | 2004 | 14634008 |
| the conversion of thyroxine to triiodothyronine in the lung: comparison of activity of type i iodothyronine 5' deiodinase in lung cancer with peripheral lung tissues. | triiodothyronine (t3) is the main active hormone, which is derived 20% from the thyroid gland and 80% from peripheral tissues. thyroxin--5' deiodinases play a leading role in maintaining appropriate t3 concentrations in the different cells and organs: including the lung. the deiodinases present in pneumocytes were found to be localised in endoplasmatic reticulum. aims of this study were: 1. to estimate activities of type i and type ii iodothyronine 5' deiodinases (di, dii) in two histological ty ... | 2003 | 14635503 |
| tumour cell and stromal features in metastatic and non-metastatic non-small cell lung carcinomas. | tumour cell behaviour depends on the interactions between nuclear genetic changes in the malignant cells and a stroma favourable for growth, invasion and metastasis. to evaluate such interactions, we studied the relationship between tumour cell and stromal features for proliferative factors, p53, microvessel density and metalloproteinases, controlled for the extent of the primary lesion (t1 to t4), in early (non-metastatic) and late (metastatic) non-small cell lung carcinomas (nsclc). | 2003 | 14636269 |
| age-dependent changes in the response of the stomach to thyroidal signaling in developmentally arrested larval summer flounder. | thyroid-dependent stomach development occurs between approximately 35 and 50 days post-hatch (dph) in laboratory-reared summer flounder larvae. the process can be blocked by thiourea (tu), and tu effects are reversed by exogenous thyroxine (t4). to establish whether a window of sensitivity exists for t4-dependent gastric development, we arrested development of larvae with 0.39 mm tu given from 26 to 61dph, and measured weekly the developmental response of the stomach to 13 nm t4 for 0, 2, or 7 d ... | 2003 | 14636630 |
| blocking the t4 lysis inhibition phenotype. | nonlysogenic escherichia coli k cells exhibit a delay in lysis when infected by t4rii phage termed lysis inhibition (lin). e. coli k cells expressing lambda rexb from either a prophage defective for rexa, or a multicopy plasmid supported t4rii infection, but prevented the establishment of lin. in addition, e. coli null mutations in either the periplasmic "tail-specific protease" tsp, or the 10sa rna ssra, completely blocked the establishment of lin following t4 infections. the expression of rexb ... | 2003 | 14637004 |
| deiodinating activity in the brown adipose tissue of rats following short cold exposure after strenuous exercise. | interscapular brown adipose tissue (ibat) activity is controlled by the sympathetic nervous system, and factors that influence thermogenesis appear to act centrally to modify the sympathetic outflow to ibat. cold exposure produces a rise in ibat temperature as a result of the increase in sympathetic outflow to ibat. this is associated with an increased thyroid activity. 3,5,3'-triiodothyronine (t3) and t4 levels increase during strenuous exercise, and, at the end of the exercise bout, a decrease ... | 2003 | 14637241 |
| afferent pathways and responses of t3-t4 spinal neurons to cervical and thoracic esophageal distensions in rats. | the purposes of this study were to (1) compare responses of t(3)-t(4) spinal neurons to thoracic and cervical esophageal distension (ted, ced) and (2) determine afferent pathways for esophageal input to these neurons. extracellular potentials of single superficial and deeper t(3)-t(4) neurons were recorded in pentobarbital anesthetized male rats. graded ted or ced was produced by water inflation (0.1-0.5 ml) of a latex balloon. ted changed activity of 121/432 (28%) neurons (114 were excited); ce ... | 2003 | 14638308 |
| cervical and high thoracic ligamentum flavum frequently fails to fuse in the midline. | cervical and high thoracic epidural anesthesia and analgesia have gained increasing importance in the treatment of painful conditions and as components of anesthetics for cardiac and breast surgery. in contrast to the hanging-drop technique, the loss-of-resistance technique is thought to rely on the penetration of the ligamentum flavum. however, the exact morphology of the ligamentum flavum at different vertebral levels remains controversial. therefore, the aim of this study was to investigate t ... | 2003 | 14639154 |
| results of surgical treatment of t4 non-small cell lung cancer. | because of location and invasion of surrounding structures, the role of surgical treatment for t4 tumors remains unclear. extended resections carry a high mortality and should be restricted for selected patients. this study clarifies the selection process in non-small cell t4 tumors with invasion of the mediastinum, recurrent nerve, heart, great vessels, trachea, esophagus, vertebral body, and carina, or with malignant pleural effusion. | 2003 | 14643822 |
| is there a role for pre-operative contrast-enhanced magnetic resonance imaging for radical surgery in malignant pleural mesothelioma? | to assess the use of contrast-enhanced magnetic resonance imaging (cemri) in addition to computed tomography in the pre-operative assessment of patients for radical surgery in malignant pleural mesothelioma. | 2003 | 14643823 |
| clinical value of video-assisted thoracoscopy for preoperative staging of non-small cell lung cancer. a prospective study of 105 patients. | this study prospectively evaluated the usefulness of thoracoscopy for staging non-small cell lung cancer in 105 consecutive patients. a comparison was made of tnm stage grouping classification according to clinical disease, thoracoscopic data, and pathological findings. in 40 (38%) patients, thoracoscopy was unreliable for assessing extent of disease due to pleural symphysis. in 13 t1 clinical lesions, thoracoscopy was unreliable in 5, clinical and thoracoscopic staging concurred in 4, but 4 cas ... | 2003 | 14644517 |
| the effect of intraperitoneal melatonin supplementation on the release of thyroid hormones and testosterone in rats with hyperthyroid. | melatonin has a general inhibitory effect on the reproductive system and thyroid functions. testosterone secretion increases in parallel to thyroid hormones in hyperthyroidism. the aim of this study was to investigate the effects of melatonin application on total t3, t4 and testosterone in hyperthyroid rats. | 2003 | 14647010 |
| anal canal cancer treatment: practical limitations of routine prescription of concurrent chemotherapy and radiotherapy. | this study is an analysis of the criteria considered when prescribing concomitant chemotherapy and radiotherapy, as a routine treatment for patients with anal canal cancer, and related complications. between 1990 and 1996, 67 patients were treated at institut curie for invasive, nonmetastatic cancer of the anal canal. median age was 65 years (range, 35-90 years). tnm stage distribution was as follows: seven t1, 17 t2, 27 t3, 16 t4, and 22 n+ patients. a total of 29 patients (i.e., five t1/t2, an ... | 2003 | 14647138 |
| [effect of perinatal asphyxia on thyroid hormones] | objective: to verify the effect of perinatal asphyxia on thyroid hormone levels in term newborn infants. methods: we carried out a case-control study with 17 term and asphyxiated (a) and 17 term and control (n) newborn infants at the hospital de clínicas de porto alegre. patients were paired according to color of skin, sex, type of delivery, gestational age, and weight at birth. we collected umbilical cord plasma t4, t3, free t4, reverse t3, and tsh after 18 to 24 hours of life and from asphyxia ... | 2001 | 14647581 |
| [persistent hyperinsulinemic hypoglycemia of infancy: case report] | objective: to report a case of persistent hyperinsulinemic hypoglycemia in twins which is a situation not yet reported in the literature. methods: report of seizures in identical twins, from consanguineous parents, with persistent hypoglycemia as cause of the seizures. laboratory tests, performed for etiological investigation of the hypoglycemia, included thyroid hormones (t4/tsh), insulin, cortisol, growth hormone, stimulation test with glucagon (to evaluate the insulin/glucose relation), and h ... | 2000 | 14647692 |
| [evaluation of the hypothalamic-pituitary-thyroid axis in children with down syndrome]. | to determine the thyroid stimulating hormone (tsh) secretion in children with down syndrome (ds), who do not present clinical and laboratory evidence of classical hypothyroidism and concomitant undetectable antibodies. | 2002 | 14647760 |
| thyroid hormone resistance and enlargement of the sella turcica during pregnancy. | case report: a 26-year-old pregnant woman was admitted to our institution running her 30 weeks of gestation. the patient had a past history of total thyroidectomy cause of a thyroid papillary carcinoma and presented with increased supraphysiological tsh levels under 250 microg t4, while slightly hyperthyroid, from the clinical point of view. partial resistance to thyroid replacement therapy or tsh-secreting tumour was evoked. pituitary mri revealed a pituitary enlargement without excluding a pit ... | 2004 | 14648184 |
| gastrectomy, peritonectomy, and perioperative intraperitoneal chemotherapy: the evolution of treatment strategies for advanced gastric cancer. | gastric cancer disseminates by hematogenous, lymphatic, and transcoelomic routes. for maximal containment of the malignant process, perioperative intraperitoneal chemotherapy is necessary in two groups of patients in whom the primary cancer can be resected. those patients who have been resected for cure and have a high likelihood of microscopic residual disease require intraperitoneal chemotherapy. this includes all t3 and t4 patients, and patients with n2 nodes present. a series of randomized a ... | 2003 | 14648781 |
| preoperative chemoradiation for locally advanced rectal cancer: rationale, technique, and results of treatment. | over the past decade, 392 patients with stage ii and iii rectal cancer have been managed with preoperative chemoradiation and surgery at the m. d. anderson cancer center (mdacc). aggressive surgical techniques such as total mesorectal excision, proctectomy with coloanal anastamosis, and multivisceral excisions have been used. initial pelvic chemoradiation is also used in patients who present with metastases. preoperative chemoradiation followed by surgery has resulted in excellent sphincter pres ... | 2003 | 14648785 |
| the effect of thyroid hormones on blood insulin level and metabolic parameters in diabetic rats. | the effect of exogenous thyroid hormones on blood insulin and metabolic parameters in diabetic rats was investigated. three groups of rats were treated with streptozotocin (stz; 50 mg/kg b.w., intravenously) and one group receiving only saline served as control. beginning with the third day after stz treatment, until the last day before decapitation, i.e. for 11 days, two groups of diabetic rats were treated with t3 (50 microg/kg b.w., i.p.) or t4 (250 microg/kg b.w., i.p.). after two weeks, stz ... | 2003 | 14649872 |
| newborn screening for congenital hypothyroidism in khon kaen university hospital, the first three years, a preliminary report. | between january 2000 and december 2002, 9,558 of 10,868 live births at srinagarind hospital, khon kaen university, khon kaen, thailand, were screened for congenital hypothyroidism (ch). dried blood spot thyroid stimulating hormone (tsh) was collected at age 48 hours or older. the cut-off tsh level for recall test was > 25 mu/l. serum thyroxine (t4), free t4 and tsh were performed during the confirmatory test. six of 24 infants recalled for confirmatory thyroid function tests had abnormal tests. ... | 2003 | 14650705 |
| [amiodarone and thyroid dysfunction: a pending problem]. | amiodarone is an antiarhytmic drug used in many clinical situations for its probed effect; it is also preferred in particular groups of patients (heart failure, post-ischemical) for its safe and its prognostic benefits. however, a substantial proportion of amiodarone treated patients develop either hypothyroidism or thyrotoxicosis. both abnormalities may occur in apparently normal glands or in glandes with pre-existed abnormalities. it may be difficult to recognize the dysfunction because of the ... | 2003 | 14650817 |
| [autoimmune phenomena during interferon-alpha therapy for hematopoietic disorders]. | the development of various kinds of autoimmune disease as a result of interferon-alpha (ifn-alpha) therapy has been reported among chronic myeloproliferative disorders(cmpd) including chronic myeloid leukemia(cml). therefore, we investigated the frequency of autoimmune disorders in 33 patients with hematopoietic diseases treated with ifn-alpha in our department. thirty-three patients (12 females, 21 males) included cases of cml (n = 23), essential thrombocythemia (et) (n = 1), multiple myeloma ( ... | 2003 | 14650958 |
| competitive adsorption of bacteriophage t4 lysozyme stability variants at hydrophilic glass surfaces. | the competitive adsorption behavior exhibited by the wild-type t4 lysozyme and two of its structural stability variants was studied by 125i radioisotope labeling. the mutant lysozymes were produced by substitution of the isoleucine residue at position 3 in the wild type with a tryptophan residue, resulting in a protein with lower structural stability, or with a cysteine residue, resulting in a protein with higher structural stability. adsorption kinetics were recorded for binary protein mixtures ... | 2004 | 14651918 |
| evaluation of intense neuromuscular blockade caused by rocuronium using posttetanic count in male and female patients. | to establish the relationship between train-of-four (tof) nerve stimulation and the number of posttetanic twitches (posttetanic count [ptc]) during neuromuscular blockade caused by rocuronium in males and females. | 2003 | 14652123 |
| alterations in the mitochondrial displacement loop in lung cancers. | alterations of the noncoding displacement (d) loop of mitochondrial dna are present in many cancers. these alterations include numerical changes in a homopolymeric c tract (pct) at positions 303-309 and single base substitutions (sbs). we determined the frequency of d-loop alterations in lung cancer cell lines and tumors, and related them to clinicopathologic features. | 2003 | 14654546 |
| discovery and characterization of a thermostable bacteriophage rna ligase homologous to t4 rna ligase 1. | thermophilic viruses represent a novel source of genetic material and enzymes with great potential for use in biotechnology. we have isolated a number of thermophilic viruses from geothermal areas in iceland, and by combining high throughput genome sequencing and state of the art bioinformatics we have identified a number of genes with potential use in biotechnology. we have also demonstrated the existence of thermostable counterparts of previously known bacteriophage enzymes. here we describe a ... | 2003 | 14654700 |
| virus inactivation in aluminum and polyaluminum coagulation. | inorganic aluminum salts, such as aluminum sulfate, are coagulants that cause small particles, such as bacteria and viruses as well as inorganic particles, to destabilize and combine into larger aggregates. in this investigation, batch coagulation treatments of water samples spiked with qbeta, ms2, t4, and p1 viruses were conducted with four different aluminum coagulants. the total infectious virus concentration in the suspension of floc particles that eventually formed by dosing with coagulant ... | 2003 | 14655704 |
| the structure of escherichia coli rusa endonuclease reveals a new holliday junction dna binding fold. | holliday junction resolution performed by a variety of structure-specific endonucleases is a key step in dna recombination and repair. it is believed that all resolvases carry out their reaction chemistries in a similar fashion, utilizing a divalent cation to facilitate the hydrolysis of the phosphodiester backbone of the dna, but their architecture varies. to date, with the exception of bacteriophage t4 endonuclease vii, each of the known resolvase enzyme structures has been categorized into on ... | 2003 | 14656440 |
| separation and recovery of dna fragments by electrophoresis through a thermoreversible hydrogel composed of poly(ethylene oxide) and poly(propylene oxide). | we have synthesized and characterized a thermoreversible hydrogel of multiplied block copolymers, composed of poly(ethylene oxide) and poly(propylene oxide), for dna electrophoresis. the aqueous solution of block copolymers turned into a hydrogel upon heating at temperatures above 10-11 degrees c, whereas it reverted into a solution upon cooling. linear double-stranded dna molecules migrated through the gel matrices at a rate that was inversely proportional to the logarithm of the dna length. th ... | 2003 | 14656528 |
| serum interleukin-18 and nitric oxide activity in bladder carcinoma. | both interleukin-18 and nitric oxide are multifunctional molecules that are involved in the different steps of carcinogenesis. | 2003 | 14656691 |
| update on locally advanced breast cancer. | locally advanced breast cancer remains a clinical challenge as the majority of patients with this diagnosis develop distant metastases despite appropriate therapy. patients with locally advanced disease encompass a wide range of clinical scenarios including advanced primary tumors (stage t4), advanced nodal disease (fixed axillary nodes or involvement of ipsilateral supraclavicular, infraclavicular, or internal mammary nodes), and inflammatory carcinomas. the prognoses of women with locally adva ... | 2003 | 14657530 |
| preoperative systemic treatment: prediction of responsiveness. | the use of predictive factors allows a more effective use of available therapies by enabling clinicians to distinguish patients likely to obtain substantial benefit from treatment from those for whom the same therapy is less likely to be effective. a most relevant aspect of clinical research is thus to develop alternative therapeutic approaches which are more efficacious for this latter group, particularly important since treatment effects are likely to be small. in the preoperative setting seve ... | 2003 | 14659132 |
| perinatal dioxin exposure and later effects--a review. | negative effects of perinatal exposure to background levels of dioxins and pcbs in europe and the usa have been documented. four facets of development are reviewed in this paper: 1. brain development and thyroid hormone metabolism. 2. hepatic effects. 3. hematopoietic system effects. 4. lung function. effects on iq and behaviour have been documented in children on both sides of the atlantic ocean. non-dioxin-like pcbs, measured in maternal and cord blood and current plasma samples have been impl ... | 2004 | 14659426 |
| esthesioneuroblastoma: endoscopic nasal and anterior craniotomy resection. | the objective was to illustrate the use of endoscopic techniques as an evolving surgical modality in excision of esthesioneuroblastoma. the authors advocate this method with excision with anterior craniotomy for removal of cribriform plate or anterior cranial fossa tumor extension. | 2003 | 14660907 |
| [mri staging of prostate cancer with the combined endorectal body phased-array coil and histologic correlation]. | evaluation of the diagnostic value of the combined endorectal body-phased array technique regarding the staging of prostate cancers, especially in the differentiation between stages t2 and t3. | 2003 | 14661137 |
| [the role of spiral ct in the preoperative evaluation of malignant gastric neoplasms]. | the purpose of this study was to evaluate the performance of spiral ct in preoperative staging in patients with gastric cancer. | 2003 | 14661602 |
| high-risk localised prostate cancer: multimodal treatment strategies combining neoadjuvant hormonal therapy and/or chemotherapy with radical prostatectomy. | for patients with newly diagnosed prostate cancer, clinical tumour stage, gleason score of the diagnostic biopsy specimen and serum prostate-specific antigen (psa) level can be combined to identify a group of men at increased risk of treatment failure after radiotherapy or radical prostatectomy. for these high-risk, but still clinically localised prostate cancers, multimodal treatment strategies may result in improved cancer control outcomes. indeed, in the setting of clinical stage t3 - t4 tumo ... | 2003 | 14661990 |