| [diagnosis and treatment in 45 patients with hashimoto's thyroiditis associated with throat symptoms]. | to assess the diagnosis and treatment in the patients complaining of throat discomfort that resulted from hashimoto's thyroiditis (ht). | 2003 | 12833688 |
| the capacity of transgenic tobacco to send a systemic rna silencing signal depends on the nature of the inducing transgene locus. | rna silencing is a conserved eukaryotic pathway in which double-stranded rna (dsrna) triggers destruction of homologous target rna via production of short-interfering rna (sirna). in plants, at least some cases of rna silencing can spread systemically. the signal responsible for systemic spread is expected to include an rna component to account for the sequence specificity of the process, and transient silencing assays have shown that the capacity for systemic silencing correlates with the accum ... | 2003 | 12834404 |
| controversies in the management of clinical t3 carcinoma of the prostate. | the therapy of all stages of prostate cancer remains controversial. perhaps the management of t3 disease is most difficult to evaluate. by definition, t3 disease is: 1) outside the capsule of the prostate (with invasion of the pericapsular tissue, the apex, the bladder neck and/or the seminal vesicles); 2) mobile; and 3) localized to the pelvis. pelvic fixation is described as t4 disease in the tnm system and will not be included in this review. comparisons of various treatment methods are diffi ... | 1994 | 12834548 |
| non-ionizing electromagnetic radiations, emitted by a cellular phone, modify cutaneous blood flow. | our surroundings are full of non-ionizing electromagnetic radiation (emr) of different frequency and power. the non-ionizing emrs emitted by television, computer and cellular phone (cf) sets have been increasing over the past few years. | 2003 | 12835541 |
| impact of overall treatment time on local control of anal cancer treated with radiochemotherapy. | between 1987 and 2000, 111 patients with epidermoid anal cancer (t1-t4 nx m0) were assigned to primary simultaneous radiochemotherapy (rct) with a radiation dose of 45 gy, performed either as a split course with 2-gy single fractions (schedule a, 1987-1996, n = 65 patients) or continuously with fractions of 1.8 gy (schedule b, 1996-2000; n = 38 patients). the chemotherapy consisted of continuous infusions of 5-fluorouracil (5-fu; 800/1,000 mg/m(2)/day, on 4/5 consecutive days, during weeks 1 and ... | 2003 | 12837978 |
| spinal osteochondroma presenting as atypical spinal curvature: a case report. | the case of an 8-year-old girl with hereditary multiple exostosis presenting with atypical spinal curvature is reported. | 2003 | 12838114 |
| [validation of the translation to catalan and spanish of cognitive evoked potential n400]. | the cognitive evoked potential n400 permits an objective assessment of the verbal semantic processing. it has been suspected to be clinically useful in cognitive abnormalities and a correlation with attentional and memory functions has been found. the present study tries to validate the translation and adaptation of the english paradigm to the catalan and spanish languages. | 2003 | 12838450 |
| [clinical staging system and surgical treatment for nasal inverted papilloma]. | to reduce the recurrent rate of the nasal inverted papilloma(nip), the staging system of the nip and the select criterion of surgical approaches were researched. | 2003 | 12838860 |
| [relation between pathologic tumor response to preoperative radiotherapy and the prognosis in patients with esophageal carcinoma]. | to analyze the relation between pathologic tumor response in preoperative radiotherapy and long-term survival in patients with esophageal carcinoma and the significance of radiosensitivity in the treatment of esophageal carcinoma. | 2003 | 12839695 |
| chest wall recurrence after mastectomy does not always portend a dismal outcome. | chest wall recurrence (cwr) after mastectomy often forecasts a grim prognosis. predictors of outcome after cwr, however, are not clear. | 2003 | 12839847 |
| central regulation of thyroidal status in a teleost fish: nutrient stimulation of t4 secretion and negative feedback of t3. | several experiments were conducted to investigate the dynamics of central regulation of thyroid function in the red drum, sciaenops ocellatus, by manipulating a well-characterized circadian rhythm of t(4) secretion. in the first experiment, red drum were reared under either a long (16l:8d) or short (8l:16d) photoperiod and fed at the same time relative to dawn. the same feeding time under different photoperiods maintained the same phase relationship between t(4) cycles under each photoperiod. th ... | 2003 | 12840837 |
| immunohistochemical study of t lymphocyte subsets on frozen substituted plastic embedding section of the bone marrow from patients with myelodysplastic syndrome and its clinical implication. | an immunohistochemical study of t lymphocyte subsets on frozen substituted plastic embedding bone marrow sections obtained from 10 patients with myelodysplastic syndrome (mds) was presented. the results of qualitative and quantitative immunohistochemical analysis are as follows: (1) labile antigens of t lymphocytes were well preserved, thus allowing analysis of distribution of t lymphocyte subsets in situ: (2) the average number of t3, t4 and t8 lymphocyte of the diffuse infiltrate was about 2%, ... | 1999 | 12840893 |
| thyroid function in breast-fed infants is not affected by methimazole-induced maternal hypothyroidism: results of a retrospective study. | for many years, breast-feeding was forbidden if methimazole (mmi) was being used. however, a few studies have demonstrated the relative safety of mmi. the purpose of this study was to evaluate thyroid function of breast-fed infants whose lactating mothers became hypothyroid while taking methimazole. between 1990 and 2001, 134 thyrotoxic lactating mothers received mmi while breast-feeding. mmi therapy was initiated between 2-8 months postpartum, 10-30 mg for the first month and 5-10 mg from the s ... | 2003 | 12841536 |
| preoperative concomitant radiotherapy and chemotherapy in ultrasound-staged t3 and t4 rectal cancer. | to analyze early results of a single institution's experience using neo-adjuvant chemoradiotherapy in locally advanced, ultrasound-staged rectal cancer. | 2003 | 12841662 |
| down-staging after two different preoperative chemoradiation schedules in rectal cancer. | to compare preoperative down-staging, toxicity and sphincter-saving procedures obtained with preoperative radiotherapy and two different concomitant chemotherapy schedules. | 2003 | 12841664 |
| remarks about usefulness of videothoracoscopic intrapericardial examination of pulmonary vessels to assess the resectability of clinical t4 lung cancer. | | 2003 | 12842588 |
| carcinoma of the parotid gland. | the low incidence and heterogeneity of histiotypes of primary parotid carcinomas makes these tumors histologically and epidemiologically difficult to evaluate. the present study reviews a single institution's experience in the treatment of primary parotid carcinomas during the last 10 years. | 2003 | 12842751 |
| [aneurysmal bone cyst of the spine in children: a 9-year follow-up of 7 cases and review of the literature]. | aneurysmal cyst is an uncommon benign primitive bone tumor generally observed in young subjects, in a spinal localization in 10% of the cases. we report the clinical, radiological, and therapeutic aspects of seven cases of aneurysmal cyst of the spine. | 2003 | 12844053 |
| purification of the bacteriophage t4 type ii dna topoisomerase. | | 1999 | 12844873 |
| factor structure of paranoid schizophrenia: a prospective study. | paranoid schizophrenics were scored and analyzed using panss and principal component method on admission (t1, 480 patients), after 4 weeks (t2, 223 patients), after 8 weeks (t3, 146 patients) and after 6 months of treatment (t4, 104 patients). seven factor models accounted for 68-74% of the variances (including models of 104 patients present at all four stages). t1 and t2 models comprised 6-7 factors and were dominated by positive and excitement symptoms. the grandiosity factor could only be ide ... | 2003 | 12845284 |
| iodized salt consumption maintains euthyroidism in iodine-deficient hypothyroid subjects. | following previous reports of impaired physical and intellectual growth, hearing deficit, hypothyroidism, and hyperendemic goiter in kiga, and the administration of iodized oil injection, this study was conducted to evaluate whether or not the effect of the injection could be sustained by iodized salt supplementation. in 1989, one ml of iodized oil solution containing 480 mg of iodine was injected in 198 schoolchildren aged 8 to 14 years. four years later, in 1993, iodized salt consumption was b ... | 2003 | 12847995 |
| high serum tsh levels are associated with depression in the elderly. | in order to investigate the association between elevated serum tsh levels and depression in the elderly, we conducted a population-based study of 451 over 60-year-old outpatients of a general university hospital. patients were divided into group i (gi) (248 individuals) with high serum tsh levels, but otherwise no important condition or disease, and group ii (gii) (203 patients) with no previous diagnosis of thyroid or mood disease, referred to the hospital because of nonthyroidal severe disease ... | 2003 | 12849083 |
| deiodinase type ii and tissue specific mrna alternative splicing in the australian lungfish, neoceratodus forsteri. | deiodinase type ii metabolises the prohormone t4 (thyroxine) into the biologically active hormone t3 (3,5,3'-triiodothyronine), at the cellular level in extrathyroidal target tissues. in juvenile lungfish, neoceratodus forsteri, a typical deiodinase type ii is present in most tissues. we have identified the full length of a 1.8 kb deiodinase type ii mrna in liver, and a truncated (1.3 kb) version in brain. both mrnas have two in frame uga codons, but only the liver form has a predicted secis str ... | 2003 | 12849964 |
| [the stratification of surgically treated t4 (stage iiib) primary lung cancers; analysis of cases with intrapulmonary metastases in the same lobe as the primary tumors (pm 1) and invading adjacent organs]. | the purpose of this article was to investigate the validity of t4 classification of primary non-small cell lung cancer. | 2003 | 12854459 |
| systemic toxicity of p,p'-dde in aged male wistar rats following oral administration. | systemic toxicity of p,p'-dde (dde) in aged male rats was investigated in wistar rats by oral administration of dde. about 10 mg/kg dde had been daily administered for 28 days from 48 weeks to 52 weeks of age and its effects were observed subsequently. the administration of dde did not give rise to any overt signs of toxicity. male reproductive organs were not affected and serum biochemistry was not impaired at the dose of this experiment. organ weights of the liver and spleen slightly increased ... | 2003 | 12854507 |
| significant association of rho/rock pathway with invasion and metastasis of bladder cancer. | the small gtp-binding protein rho and its best-characterized downstream effector rho-associated serine-threonine protein kinase, rock, participate in actin cytoskeleton organization, and are linked to pathogenesis and progression of several human tumors. we investigated the roles of rho and rock in bladder cancer. experimental design: using western blotting, we quantitated rho and rock protein expression in paired tumor and nontumor surgical samples from 107 consecutive japanese patients with bl ... | 2003 | 12855641 |
| a new approach to the synthesis of the 5'-end substituted oligonucleotides using t4 polynucleotide kinase and gamma-amides of atp bearing photoreactive groups. | | 2003 | 12856418 |
| endocrine changes in a rat model of chronic hypoxia mimicking cyanotic heart disease. | the endocrine system plays an important role in the adaptation to hypoxia. the aim of this study is to assess the effect of chronic hypoxia on endocrine changes in a neonatal animal model mimicking cyanotic heart disease. | 2003 | 12856806 |
| effects of inula racemosa root and gymnema sylvestre leaf extracts in the regulation of corticosteroid induced diabetes mellitus: involvement of thyroid hormones. | the efficacy of inula racemosa (root) and gymnema sylvestre (leaf) extracts either alone or in combination was evaluated in the amelioration of corticosteroid-induced hyperglycaemia in mice. simultaneously thyroid hormone levels were estimated by radio-immunoassay (ria) in order to ascertain whether the effects are mediated through thyroid hormones or not. while the corticosteroid (dexamethasone) administration increased the serum glucose concentration, it decreased serum concentrations of the t ... | 2003 | 12857006 |
| stereological analysis of the cerebellum of 24-day old rats with propylthiouracil-induced hypothyroidism. | to investigate the structural parameters of the developing cerebellum in propylthiouracil (ptu)-induced hypothyroidism during pre and postnatal stages in 24 day old rat pups. | 2000 | 12858908 |
| crystal structures of the t4 phage beta-glucosyltransferase and the d100a mutant in complex with udp-glucose: glucose binding and identification of the catalytic base for a direct displacement mechanism. | t4 phage beta-glucosyltransferase (bgt) is an inverting glycosyltransferase (gt) that transfers glucose from uridine diphospho-glucose (udp-glucose) to an acceptor modified dna. bgt belongs to the gt-b structural superfamily, represented, so far, by five different inverting or retaining gt families. here, we report three high-resolution x-ray structures of bgt and a point mutant solved in the presence of udp-glucose. the two co-crystal structures of the d100a mutant show that, unlike the wild-ty ... | 2003 | 12860129 |
| long-term toxicity after definitive chemoradiotherapy for squamous cell carcinoma of the thoracic esophagus. | to assess the long-term toxicity after definitive chemoradiotherapy (crt) for squamous cell carcinoma (scc) of the esophagus. | 2003 | 12860946 |
| viability of streptococcus mutans on transparent and opaque toothbrushes. | the objective of this study was to evaluate the viability of the microorganism streptococcus mutans on toothbrushes made of opaque and transparent materials. | 2003 | 12861791 |
| neonatal congenital hypothyroidism screening in addis ababa, ethiopia. | to determine the prevalence of congenital hypothyroidism, establish reference levels for thyroid stimulating hormone (tsh), and determine the cut-off points of tsh level for neonatal screening in congenital hypothyroidism. | 2000 | 12862157 |
| musculoskeletal manifestations in patients with thyroid disease. | thyroid dysfunction may cause musculoskeletal symptoms. we have evaluated the prevalence of adhesive capsulitis, dupuytren's contracture, trigger finger, limited joint mobility and carpal tunnel syndrome in a series of patients with various thyroid diseases and differing levels of function. | 2003 | 12864792 |
| recombinant human tsh testing is a valuable tool for differential diagnosis of congenital hypothyroidism during l-thyroxine replacement. | the differential diagnosis of congenital hypothyroidism (ch) is aimed to distinguish transitory from permanent forms, to optimize l-thyroxine (l-t4) therapy to replacement or tsh-suppressive regimens, and to reach accurate definition of the clinical and biochemical phenotype for subsequent genetic investigations and counselling. therefore, l-t4 therapy is presently withdrawn in most instances and investigations are performed in a disturbing hypothyroid state. | 2003 | 12864801 |
| the effect of body weight and weight loss on thyroid volume and function in obese women. | thyroid volume and thyroid function may vary in obese and nonobese women. it is not known whether weight loss could affect thyroid volume and function in obese subjects. | 2003 | 12864805 |
| exploring associations between serum levels of select organochlorines and thyroxine in a sample of new york state sportsmen: the new york state angler cohort study. | this preliminary study investigated associations between environmental organochlorine compounds and thyroid function in a sample of 66 sportsmen selected from among participants in the new york state angler cohort study. a cross-sectional design was employed with the primary goal of the analysis being the generation of specific testable hypotheses. blood samples were analyzed for compounds based on a priori identified literature-cited evidence of thyroid disruption. these included hexachlorobenz ... | 2003 | 12865048 |
| deubiquitination of type 2 iodothyronine deiodinase by von hippel-lindau protein-interacting deubiquitinating enzymes regulates thyroid hormone activation. | the type 2 iodothyronine deiodinase (d2) is an integral membrane er-resident selenoenzyme that activates the pro-hormone thyroxine (t4) and supplies most of the 3,5,3'-triiodothyronine (t3) that is essential for brain development. d2 is inactivated by selective conjugation to ubiquitin, a process accelerated by t4 catalysis and essential for the maintenance of t3 homeostasis. a yeast two-hybrid screen of a human-brain library with d2 as bait identified von hippel-lindau protein-interacting deubi ... | 2003 | 12865408 |
| quantitative trait loci for insulin-like growth factor i, leptin, thyroxine, and corticosterone in genetically heterogeneous mice. | genotype information was collected at 87 loci in a group of 1,108 um-het3 mice bred as the progeny of [balb/cj x c57bl/6j]f1 mothers and [c3h/hej x dba/2j]f1 fathers, for which thyroxine (t4), insulin-like growth factor i (igf-i), and leptin levels had been measured at 4 and 15 mo of age. the data provided significant evidence for quantitative trait loci (qtl) modulating igf-i levels on chromosomes 1, 3, 8, 10, and 17; for loci affecting t4 on chromosomes 4, 15, and 17; and for leptin on chromos ... | 2003 | 12865502 |
| evaluation of chest radiography versus chest computed tomography in screening for pulmonary malignancy in advanced head and neck cancer. | to evaluate the role of chest radiography versus chest computed tomography (ct) in screening for pulmonary malignancy in advanced head and neck squamous cell carcinoma (hnscc). | 2003 | 12866595 |
| tone perception ability of cantonese-speaking children. | studies have shown that while children acquire all cantonese tones by age two, they are not able to label them reliably until approximately age 10. one possible explanation for the large age discrepancy may be the different methodologies used. this study aimed to (1) investigate a new research design for the collection of reliable tone perception data from young children; (2) compare lexical and nonlexical items for testing tone perception ability; and (3) identify the relative ease of perceivin ... | 2002 | 12866910 |
| [clinicopathological characteristics of primary nasopharyngeal adenocarcinoma]. | the primary nasopharyngeal adenocarcinoma (npac) is rare. this study was designed to investigate the clinicopathological characteristics of primary npac. | 2003 | 12866970 |
| cardiopulmonary bypass is not associated with increased jugular venous blood free radical activity. | we have measured jugular venous oxygen saturation (sjv(o2)) and lactate, arterial and jugular venous blood levels of lipid peroxidation products--malondialdehyde (mda) and diene conjugates as an index of free radical activity in eight adults undergoing coronary artery bypass surgery. measurements were carried out at six specific times: t1--within 5 min before cardiopulmonary bypass (cpb), t2--within the first minute after the commencement of cpb, t3--during stable temperature (28 degrees c) on c ... | 2003 | 12868790 |
| neoadjuvant docetaxel in locally advanced breast cancer. | neoadjuvant chemotherapy produces substantial increases in clinical response rates and rates of breast conserving therapy. pathologic response rate, though generally low, is an important outcome as it is presumably associated with eradication of micrometastatic disease and may likely result in improved outcomes. anthracyclines have long been considered the most efficacious chemotherapy agents for neoadjuvant therapy of early breast cancer. unfortunately, not all patients respond to neoadjuvant a ... | 2003 | 12868802 |
| a thyroid hormone receptor alpha gene mutation (p398h) is associated with visceral adiposity and impaired catecholamine-stimulated lipolysis in mice. | thyroid hormone has profound effects on metabolic homeostasis, regulating both lipogenesis and lipolysis, primarily by modulating adrenergic activity. we generated mice with a point mutation in the thyroid hormone receptor alpha (tralpha) gene producing a dominant-negative tralpha mutant receptor with a proline to histidine substitution (p398h). the heterozygous p398h mutant mice had a 3.4-fold (p < 0.02) increase in serum thyrotropin (tsh) levels. serum triiodothyronine (t3) and thyroxine (t4) ... | 2003 | 12869545 |
| long-distance conformational changes in a protein engineered by modulated sequence duplication. | there are few, if any, known instances in which a biological signal is transmitted via a large conformational change through the body of a protein. we describe here a mutant of t4 lysozyme that was engineered to permit structural change at a distance. the design uses a tandem sequence repeat that makes it possible to transmit large-scale structural changes from one end of an alpha-helix to the other over a distance of 17-25 a. the method should be of general applicability and may make it possibl ... | 2003 | 12869697 |
| clear cell ependymoma with a lipidized component that developed in the thoracic spinal cord. | the authors report a case of clear cell ependymoma with a lipidized component that developed in the thoracic spinal cord. a 59-year-old man was admitted to the hospital with an itchy pain in the left forearm to the left anterior and lateral chest for the past three years. neurological findings on admission included dissociated sensory disturbance below the c8 level and increased deep tendon reflex in both lower extremities. an mri scan of the spinal cord revealed an intramedullary tumor with a l ... | 2003 | 12870256 |
| patterns of cervical metastasis from carcinoma of the oral tongue. | background: cancer of the oral tongue is the second most common cancer among males in various parts of india. despite advances in diagnosis and treatment the failure rates in cancer of the oral tongue are high and survival poor. majority of these failures occur in untreated neck. method: a retrospective review of the records of 75 patients undergoing surgery for the treatment of squamous cell carcinoma of the oral tongue was carried out to ascertain the pattern of metastasis in the neck and to e ... | 2003 | 12871595 |
| identification of monocarboxylate transporter 8 as a specific thyroid hormone transporter. | transport of thyroid hormone across the cell membrane is required for its action and metabolism. recently, a t-type amino acid transporter was cloned which transports aromatic amino acids but not iodothyronines. this transporter belongs to the monocarboxylate transporter (mct) family and is most homologous with mct8 (slc16a2). therefore, we cloned rat mct8 and tested it for thyroid hormone transport in xenopus laevis oocytes. oocytes were injected with rat mct8 crna, and after 3 days immunofluor ... | 2003 | 12871948 |
| [thyroid function in patients with yusho]. | to evaluate chronic effect of polychlorinated biphenyl (pcb) on thyroid functions, thyroid hormone levels were studied in 115 patients with yusho in 2002. serum level of thyroid stimulating hormone (tsh) was elevated in 13 cases (11.3%). all of them showed normal triiodothyronine (t3) and thyroxine (t4) levels, and regarded as latent hypothyroidism. there were no significant correlations between blood pcb concentrations and tsh levels, t3 levels or t4 levels. we conclude that abnormality of tsh ... | 2003 | 12872709 |
| results of definitive irradiation in a series of 305 epidermoid carcinomas of the anal canal. | to evaluate our data concerning the prognostic factors for locoregional control, survival, late complications, and sphincter conservation in a series of epidermoid cancers of the anal canal without clinical evidence of metastasis. | 2003 | 12873670 |
| management of primary anal canal adenocarcinoma: a large retrospective study from the rare cancer network. | primary adenocarcinoma of the anus is a rare tumor. the current standard treatment consists of abdominoperineal resection (apr). the aim of this rare cancer network study was to evaluate the prognostic factors and outcome after the three most commonly used treatment approaches. | 2003 | 12873671 |
| long-term outcome of 525 patients with mycosis fungoides and sezary syndrome: clinical prognostic factors and risk for disease progression. | to study and update the clinical characteristics and long-term outcome of our patients with mycosis fungoides (mf) and sézary syndrome (ss), and to identify important clinical factors predictive of survival and disease progression. | 2003 | 12873880 |
| high incidence of lymph node metastasis in major salivary gland cancer. | to analyze the incidence and risk factors for clinically apparent and occult lymph node metastases in patients with major salivary gland cancers. | 2003 | 12874071 |
| theoretical studies on solvation contribution to the thermodynamic stability of mutants of lysozyme t4. | atomic solvation parameters (asps) are widely used to estimate the solvation contribution to the thermodynamic stability of proteins as well as the free energy of association for protein-ligand complexes. in view of discrepancies in the results of free energies of solvation of folding for various proteins obtained using different atomic solvation parameter sets, systematic studies have been carried out for the calculation of accessible surface area and the changes in free energy of solvation of ... | 2003 | 12874374 |
| carbamazepine does not alter biochemical parameters of bone turnover in healthy male adults. | it is still not completely clear whether or not carbamazepine (cbz) causes alterations in vitamin d status and in bone metabolism. the objective of this study was therefore to investigate prospectively in healthy adults the effects of cbz on serum levels of 25-hydroxyvitamin d (25ohd) and on biomarkers of bone formation and resorption. twenty-one free-living male adults were taking 800 mg/day cbz for 10 weeks. the study was performed from december 1997 until september 1998 at a geographic latitu ... | 2003 | 12874705 |
| hormone levels and cataract scores as sex-specific, mid-life predictors of longevity in genetically heterogeneous mice. | serum levels of thyroxine (t4), leptin, and insulin-like growth factor-i (igf-i), as well as cataract severity, were evaluated as predictors of life span in a population of genetically heterogeneous mice (um-het3). long life span was predicted by low levels of leptin at age 4 months in females, and by low levels of igf-i at age 15 months and high levels of t4 at age 4 months, in males. cataract severity at either 18 or 24 months was also a significant predictor of life span in females only, but ... | 2003 | 12875743 |
| defining the atpase center of bacteriophage t4 dna packaging machine: requirement for a catalytic glutamate residue in the large terminase protein gp17. | double-stranded dna packaging in icosahedral bacteriophages is driven by an atpase-coupled packaging machine constituted by the portal protein and two non-structural packaging/terminase proteins assembled at the unique portal vertex of the empty viral capsid. recent studies show that the n-terminal atpase site of bacteriophage t4 large terminase protein gp17 is critically required for dna packaging. it is likely that this is the dna translocating atpase that powers directional translocation of d ... | 2003 | 12875841 |
| comparison of transrectal sonography and double-contrast mr imaging when staging rectal cancer. | the aim of this study was the prospective comparison of the diagnostic yield of transrectal sonography and double-contrast mr imaging for preoperative staging of rectal cancer. subjects and methods. thirty-nine rectal cancer patients (20 men, 19 women) underwent transrectal sonography performed with a 10-mhz endoanal probe and mr imaging (1.0 t or 1.5 t) using a whole-body coil. after rectal application of a superparamagnetic iron oxide mr contrast agent, t1- and t2-weighted images and gadoliniu ... | 2003 | 12876020 |
| perceived horizontal body position in healthy and paraplegic subjects: effect of centrifugation. | the perception of body position is mainly mediated by otolith information and visual cues. it has been shown, however, that proprioceptive sources are also involved. to distinguish between the contributions of the vestibular and nonvisual extra-vestibular information to graviception, we tested the effects of a stimulus that leaves the vestibular input unchanged but modifies the information from sense organs located more caudal along the trunk. this was achieved by bringing subjects into a horizo ... | 2003 | 12878718 |
| [effects of enflurane on myocardial reperfusion injury during cardiac surgery with cardiopulmonary bypass]. | to study the effects of inhalation enflurane (enf) before aortic clamping on myocardial reperfusion injury in cardiac surgery with cardiopulmonary bypass (cpb). | 2003 | 12881869 |
| [alteration of p53 protein expression and p53 gene in laryngeal carcinoma]. | to study the prevalence of p53 protein expression and p53 gene mutation in laryngeal carcinoma. | 2003 | 12881872 |
| construction of linear functional expression elements with dna and rna hybrid primers: a flexible and fast method for proteomics. | two methods of constructing linear functional expression elements (lfee) using hybrid dna and rna primers in dna amplification for rapid gene expression are described. in both methods, it is not necessary to have additional transformation or bacterial propagation. the promoter, open reading frame (orf) and terminator are amplified using pfu or taq dna polymerase. three elements containing dna or rna overhang are covalently ligated by t4 dna ligase. the recombinant molecule is amplified with elem ... | 2003 | 12882584 |
| [primary adenoid cystic carcinoma of the nasopharynx and its relation to epstein-barr virus infection]. | to investigate the clinicopathologic characteristics of primary nasopharyngeal adenoid cystic carcinoma (npacc) and its relation to epstein-barr virus (ebv) infection in guangzhou where is a high-incidence area of ebv-associated nasopharyngeal carcinoma (npc). | 2003 | 12882689 |
| effect of iodine and selenium upon thyroid function. | iodine is an essential element with unique role in organism: it is indispensable component of thyroid hormones. after binding with specific nuclear receptor, t3/t4 induce transcription of genetic code via mrna and regulate proteosynthesis in most tissues. thyroid hormones regulate rate of metabolic processes and consequently development of organism. czech republic was in past typical region with moderate to severe iodine deficiency. therefore epidemiological survey was started in randomly select ... | 2003 | 12884559 |
| [construction and expression of the recombinant plasmid pcdna3.1/ts87 of trichinella spiralis]. | to construct and express dna plasmid of trichinella spiralis. | 2003 | 12884619 |
| concomitant boost radiotherapy for muscle invasive bladder cancer. | to evaluate the feasibility and efficacy of a concomitant partial bladder boost schedule in radiotherapy for invasive bladder cancer, coupling a limited boost volume with shortening of the overall treatment time. | 2003 | 12885455 |
| hyperthyroidism increases the uncoupled atpase activity and heat production by the sarcoplasmic reticulum ca2+-atpase. | the sarcoplasmic reticulum ca2+-atpase is able to modulate the distribution of energy released during atp hydrolysis, so that a portion of energy is used for ca2+ transport (coupled atpase activity) and a portion is converted into heat (uncoupled atpase activity). in this report it is shown that t4 administration to rabbits promotes an increase in the rates of both the uncoupled atpase activity and heat production in sarcoplasmic reticulum vesicles, and that the degree of activation varies depen ... | 2003 | 12887329 |
| health-related quality of life and psychosocial factors in patients with prostate cancer scheduled for radical prostatectomy or external radiation therapy. | to assess whether baseline health-related quality of life (hrqol) and psychosocial profiles differ in patients with prostate cancer scheduled for radical prostatectomy (rp) or external radiation therapy (ert), as there is evidence that hrqol is influenced by psychosocial factors (pfs), so that any variation at baseline should be considered when comparing the effect of therapy on hrqol. | 2003 | 12887470 |
| comparison of two functional independence scales with a participation measure in post-stroke rehabilitation. | the objectives of the study were to compare the association and responsiveness of the functional autonomy measurement system (smaf) and functional independence measure (fim) as outcome measures addressing functional independence in stroke patients involved in an intensive rehabilitation program and to compare their relationships with a social participation measure after rehabilitation period. one hundred and thirty-two people who had a stroke were evaluated with the smaf and fim during the rehab ... | 2003 | 12888229 |
| the structure of the receptor-binding domain of the bacteriophage t4 short tail fibre reveals a knitted trimeric metal-binding fold. | adsorption of t4 bacteriophage to the escherichia coli host cell is mediated by six long and six short tail fibres. after at least three long tail fibres have bound, short tail fibres extend and bind irreversibly to the core region of the host cell lipo-polysaccharide (lps), serving as inextensible stays during penetration of the cell envelope by the tail tube. the short tail fibres consist of a parallel, in-register, trimer of gene product 12 (gp12).x-ray crystallography at 1.5a resolution of a ... | 2003 | 12888344 |
| assembly of linear functional expression elements with dna fragments digested with asymmetric restriction endonucleases. | a three-step method is described to assemble linear functional expression elements for rapid gene expression. in step one, a eukaryotic promoter, an open reading frame and a transcription terminator are pcr-amplified individually with primers containing recognition sites of asymmetric restriction endonucleases. in step two, the three dna fragments, digested with corresponding restriction endonucleases, are directionally joined by t4 dna ligase to assemble linear functional expression elements. i ... | 2003 | 12889803 |
| thyroid indices and treatment outcome in bulimia nervosa. | this study examined the thyroxine (t4) and free t4 (ft4) status of women with bulimia nervosa and its value as a predictor of outcome. | 2003 | 12890273 |
| plasma thyroid hormone concentrations in dogs competing in a long-distance sled dog race. | plasma thyroxine (t4), 3,5,3'-triiodothyronine (t3), total protein, and albumin concentrations were measured in 15 dogs both before and after completion, and in an additional 16 dogs before and 24 dogs after completion, of a long-distance sled dog race. the plasma t4 concentration (mean +/- sd) decreased significantly from 18.2 +/- 5.4 nmol/l before to 14.3 +/- 3.5 nmol/l after the race in dogs evaluated at both times and decreased significantly from 21.8 +/- 10.5 nmol/l before to 15.8 +/- 4.9 n ... | 2003 | 12892315 |
| [rhabdomyolysis, hyponatremia and fever in a patient with schmidt's syndrome]. | a 38-year-old man had fever (40 degrees c) and a swollen right leg. two weeks before admission he had received non-steroid anti-inflammatory drugs (paracetamol and ibuprofen) after a tooth extraction. some weeks before he had noticed a rough voice and a dry skin. | 2003 | 12894392 |
| [chemoradiotherapy for esophageal cancer]. | since mucosal (t1a) esophageal cancer is well controlled by endoscopic treatment, chemoradiotherapy (crtx) is not indicated. however, for a submucosal (t1b, n0) esophageal cancer, crtx may be the first line of treatment, since it can provide a good response rate, with an excellent survival rate comparable to that after esophagectomy. definitive crtx is also in the first line of treatment for a t4 esophageal cancer, because there was no difference in the survival rate between crtx with surgery an ... | 2003 | 12894707 |
| [construction, expression and antigenic study of bivalent vaccine candidate with 26,000 omp and heat short protein a of human helicobacter pylori]. | to construct a recombinant vector containing gene encoding heat shock protein a (hspa) and outer membrane protein (omp) with relative molecule mass (mr) of 13,000 and 26,000 respectively from human helicobacter pylori (hp) and be expressed in e. coli bl21, as well as analyse its antigenic for the exploiting vaccine of hp. | 2003 | 12895340 |
| antithyroid antibody-linked symptoms in borderline personality disorder. | circulating thyroid autoantibodies are more prevalent in patients with mood disorders than in the general population, but longitudinal clinical data that establish a relationship between thyroid antibody status and the course of any psychiatric syndrome have been lacking. in addition, scant attention has been paid to thyroid hormones and autoimmunity in borderline personality disorder (bpd). we report a case of a patient with classic bpd whose fluctuating mood and, especially, psychotic symptoms ... | 2003 | 12897379 |
| effects of prostaglandin e1, melatonin, and oxytetracycline on lipid peroxidation, antioxidant defense system, paraoxonase (pon1) activities, and homocysteine levels in an animal model of spinal cord injury. | investigation of the effects of prostaglandin e1, melatonin, and oxytetracycline on lipid peroxidation, antioxidant and paraoxonase activities, and homocysteine levels in an experimental model of spinal cord injury. | 2003 | 12897486 |
| parotid carcinoma: impact of clinical factors on prognosis in a histologically revised series. | to analyze clinical data and possible prognostic factors of patients with primary carcinoma of the parotid gland. | 2003 | 12897568 |
| serotonin effect on deiodinating activity in the rat. | serotonin (5-ht) and thyroid hormones are part of a complex system modulating eating behaviour and energy expenditure. 5-deiodinase (5-d) converts the relatively inactive thyroxine (t4) to triiodothyronine (t3), and its activity is an indirect measure of t3 production in peripheral tissues, particularly in the brain, intrascapular brown adipose tissue (ibat), heart, liver, and kidney. we evaluated the effect of 5-ht on 5'-d activity during basal conditions and after short (30 min) cold exposure ... | 2003 | 12897823 |
| [the neck treatment of cn0 patients with squamous cell carcinoma of buccal mucosa]. | the purpose of this study was to discuss the principle in neck treatment of cn0 patients with squamous cell carcinoma of buccal mucosa. | 2003 | 12898760 |
| dynamic computed tomography assessment of local extent and resectability of esophageal carcinoma. | the aim of this study was to define the usefulness of dynamic computed tomography in the preoperative assessment of esophageal cancer. ct scanning was performed in 93 patients with proven carcinoma of the esophagus. all results of ct were compared with surgical and pathologic findings. the analysis used the ajcc classification adapted to the needs of ct. the local extent of the primary tumour (t-stage) and its resectability were assessed and compared for different locations of the tumour. the ov ... | 2002 | 12898815 |
| experimental evidence for a beta beta alpha-me-finger nuclease motif to represent the active site of the caspase-activated dnase. | the caspase-activated dnase (cad) is an important nuclease involved in apoptotic dna degradation. results of a sequence comparison of cad proteins with beta beta alpha-me-finger nucleases in conjunction with a mutational and chemical modification analysis suggest that cad proteins constitute a new family of beta beta alpha-me-finger nucleases. nucleases of this family have widely different functions but are characterized by a common active-site fold and similar catalytic mechanisms. according to ... | 2003 | 12899615 |
| cell-cycle regulators and the ki-67 labeling index can predict the response to chemoradiotherapy and the survival of patients with locally advanced squamous cell carcinoma of the esophagus. | we investigated whether aberrant p53 and p16 expression, the ki-67 labeling index (li), and int-2/cyclin d1 gene amplification predict the response to chemoradiotherapy (crt) in patients with locally advanced esophageal squamous cell carcinoma (escc). | 2003 | 12900371 |
| prognostic significance of the deleted in colorectal cancer gene protein expression in high-risk resected gastric carcinoma. | the deleted in colorectal cancer (dcc) gene is a candidate tumor suppressor gene that may be associated with differentiation and proliferation of normal cells. loss of heterozygosity (loh) of 18q, where the gene is located, and absence of dcc protein expression have been associated with worse prognosis in certain subgroups of patients with colorectal adenocarcinoma. we studied the prognostic significance of loss-of-protein expression in 66 patients with resected gastric cancer with a high probab ... | 2003 | 12901278 |
| fluorescence microscopic visualization of a dna-cationic fullerene complex. | cationic fullerene derivative 1, which is soluble in aqueous medium, bound to double stranded dna. observation of coliphage t4 dna in the absence and presence of 1 by fluorescence microscopy suggested that 1 bound to dna along its groove. upon irradiation of visible light on the dna complex of 1, dna was cleaved dramatically. the process of dna photo-cleavage could be monitored continuously by fluorescence microscopy. | 2000 | 12903324 |
| preparation of dna catenanes and observation of their topological structures by atomic force microscopy. | dna catenanes have been prepared by the reaction of t4 dna ligase with linear dna in the presence of nicked dna. single molecular images of dna catenanes and large circular dnas have been clearly observed by afm using a tapping mode at room temperature and in an ambient atmosphere. | 2000 | 12903352 |
| single long dna molecule analysis using fluorescence microscopy. | single long dna molecule (t4 dna) in agarose gel was visualized with a fluorescence microscope. we confirmed alternating current electric fields is effective for stretching of single dna molecule in agarose gel. this stretching phenomenon was observed with wide range of agarose gel concentration from 0.5%(w/v) to 1.5%. from this observation, the presence of agarose gel fiber is essential for this stretching phenomenon. the stretching process of several dna molecules in gel shows discontinuity, w ... | 2000 | 12903361 |
| salt-dependent folding of long duplex dna by histone h1. | it is found that t4 phage dna complexed with histone h1 assembled into a string-of-bead structure, when the complex is prepared by a gentle diluting procedure from a high salt solution (2 m nacl) to a low salt solution (50 mm nacl). we used fluorescence microscopy to perform the real-time observation on formation and motion of a string-of-bead structure. spatial histone h1 distribution on the dna-h1 complex is observed by immuno-fluorescence microscopy. | 2000 | 12903384 |
| [effect of tripterygium wilfordii hook t4 monomer on proliferation and interleukin-6 production of synovial fibroblasts of patients with rheumatoid arthritis]. | tripterygium wilfordii hook multi-glycosides t2 has been wildly used in china in treatment of ra. t4 was abstracted from t2 and was reported much more efficient in anti-inflammatory and immune suppression than t2. this study was to investigate the effect tripterygium wilfordii hook t4 monomer on proliferation and interleukin-6 production of synovial fibroblasts of patients with rheumatoid arthritis. | 2000 | 12903526 |
| [early evaluation using pet-fdg of the efficiency of neoadjuvant radiochemotherapy treatment in locally advanced neoplasia of the lower rectum]. | preoperative chemoradiation allows downstaging of locally advanced rectal cancer and in selected patients also a sufficient downsizing to ensure sphincter preservation. selection of patients warranting a preoperative approach is improved by magnetic resonance imaging (mri) which is able to define the involvement of mesorectal circumferential margin. similarly it would be crucial to define the response to chemoradiation during the treatment but traditional morphologic imaging techniques may fail ... | 2003 | 12903544 |
| [hormonal therapy in oncologic treatment: pathogenic hypotheses and interactions between thyroid and breast pathologies]. | the aim to individuate the eventual correlation between the two pathologies has justified deeper studies to achieve new prospective approaches for both disease. | 2003 | 12903598 |
| the sympathetic contributions to the cardiac plexus. | cardiac sympathetic denervation for intractable angina pectoris in patients unsuitable for conventional revascularization is currently gaining popularity since this procedure may be performed via minimally invasive surgery. a thorough understanding of cardiac innervation and its variations is crucial to successfully effect cardiac denervation. this study aimed to demonstrate the cervical and thoracic sympathetic contributions to the cardiac plexus. the cervical and thoracic sympathetic trunks in ... | 2003 | 12904902 |
| increased prevalence of hypothyroidism among human immunodeficiency virus-infected patients: a need for screening. | the aim of this cross-sectional multicenter study was to determine the prevalence of and risk factors for hypothyroidism in human immunodeficiency virus (hiv)-infected patients. free t4, free t3, and thyroid-stimulating hormone levels were determined. data on age, sex, weight variation, smoking status, duration of hiv infection, centers for disease control and prevention disease stage, cd4 cell count, hiv rna load, lipodystrophy, hiv-hepatitis c virus coinfection, and antiretroviral treatment (t ... | 2003 | 12905143 |
| effect of thyroid hormone on the development and gene expression of hormone receptors in rat testes in vivo. | thyroid hormone is known to play a pivotal role in the regulation of prepuberal rat testes development and function with specific influence on the differentiation of sertoli cells, the only cell type that expresses thyroid hormone receptors in testes. to explore in vivo effects of thyroid hormone on testes development and the regulation of testicular gene expression, the hyper- and hypothyroid rat models were established by t3 injection to pups (ip 100 microg/kg bw) and by oral administration of ... | 2003 | 12906371 |
| maternal hypothyroidism may affect fetal growth and neonatal thyroid function. | to investigate the pituitary-thyroid axis function in the early neonatal period of newborns to hypothyroid mothers who have been apparently adequately treated. | 2003 | 12907094 |
| hypothyroidism in thyroid transcription factor 1 haploinsufficiency is caused by reduced expression of the thyroid-stimulating hormone receptor. | humans expressing one allele of the thyroid transcription factor 1 (ttf1) gene have neurological symptoms and increased serum tsh with variable degrees of hypothyroidism. ttf1+/- mice have also poor coordination and increased serum tsh concentration (205 +/- 22 vs. 92 +/- 12 mu/liter; p < 0.001) and slightly lower t4 (46 +/- 3 vs. 63 +/- 6 nmol/liter; p < 0.02) as compared with ttf1+/+ mice. to determine whether the hypothyroidism is of central or primary origin, we examined the bioactivity of t ... | 2003 | 12907760 |
| severely sustained vomiting as the main symptom in a man with thyrotoxicosis. | thyrotoxicosis has a variety of presentations. vomiting as a main presenting symptom of thyrotoxicosis is uncommon. we report a 40-year-old male with thyrotoxicosis who presented with sustained vomiting as the main symptom. he also had weight loss, about 10 kg over this 20-day period, and dizziness, particularly in the upright position. esophagogastroduodenoscopy and abdominal ultrasonography were negative. laboratory data were unremarkable except serum t4 of 21.2 microg/dl, t3 of 574 ng/dl and ... | 2003 | 12908576 |